Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
(no author information available yet)
No abstract text is available yet for this article.
June 2022: Obesity
#22
RANDOMIZED CONTROLLED TRIAL
Uma V Mahajan, Disep I Ojukwu, Dan E Azagury, Debra L Safer, Tricia Cunningham, Casey H Halpern
OBJECTIVE: A first-in-human responsive deep brain stimulation (rDBS) trial (NCT03868670) for obesity is under way, which is based on promising preclinical evidence. Given the upfront costs of rDBS, it is prudent to examine the success threshold for cost-effectiveness compared with laparoscopic Roux-en-Y gastric bypass (LRYGB). METHODS: Efficacy and safety data on LRYGB and safety data on rDBS were collected for established indications through a literature search...
February 2022: Obesity
#23
COMMENT
Dorian M Kusyk, Donald Whiting
No abstract text is available yet for this article.
February 2022: Obesity
#24
JOURNAL ARTICLE
Mohammad Sediq Sahrai, Inge Huybrechts, Carine Biessy, Sabina Rinaldi, Pietro Ferrari, Abdul Wahed Wasiq, Marc J Gunter, Laure Dossus
BACKGROUND: Non-communicable diseases (NCDs) cause more than 70% of deaths worldwide and share modifiable risk factors including obesity and metabolic abnormalities. Over the past 15 years, many changes in lifestyle, dietary patterns, physical activity, and socioeconomic status have been observed in the Afghan population. This study aims to investigate which specific lifestyle factors, dietary patterns, and characteristics of Westernization are associated with an increased risk of being overweight or obese and with poor metabolic health in the Afghan population...
January 7, 2022: Journal of Epidemiology and Global Health
#25
Effectiveness of Deep Brain Stimulation in Reducing Body Mass Index and Weight: A Systematic Review.
William Omar Contreras López, Paula Alejandra Navarro, Santiago Crispín
BACKGROUND: Obesity has become a major public health concern worldwide, with current behavioral, pharmacological, and surgical treatments offering varying rates of success and adverse effects. Neurosurgical approaches to treatment of refractory obesity include deep brain stimulation (DBS) on either specific hypothalamic or reward circuitry nuclei, which might contribute to weight reduction through different mechanisms. We aimed to determine the safety and clinical effect of DBS in medical refractory obesity...
2022: Stereotactic and Functional Neurosurgery
#26
Trevor Luck, Dorian M Kusyk, Donald Whiting
While a headache can have a wide variety of clinical presentations, it may occasionally be a red flag for underlying pathology that should prompt further investigation. Here, we present a case report demonstrating headache as an uncommon symptom of deep brain stimulation (DBS) device failure and discuss its clinical significance in the rapidly expanding list of current indications of DBS treatment. A 61-year-old female underwent bilateral hypothalamic DBS implantation for refractory morbid obesity. After a successful course involving significant weight loss, the patient began to experience worsening of her chronic headaches, refractory to her existing regiment...
July 2021: Curēus
#27
JOURNAL ARTICLE
Denys Fontaine, Serena Santucci
Benefits from symptomatic and etiologic treatments in Alzheimer's Disease (AD), the most frequent dementia, are still insufficient. During the last decade, several studies showed that electrical stimulation of memory circuits could enhance memory in humans without memory impairment. First, improvement of verbal recollection was reported after deep brain stimulation (DBS) of the fornix in the hypothalamus in a patient treated for morbid obesity. Several studies in epileptic patients explored by deep electrodes reported that visuo-spatial memorization was facilitated by electrical stimulation of the entorhinal cortex or theta burst stimulation of the fornix...
2021: International Review of Neurobiology
#28
REVIEW
Flavia Venetucci Gouveia, Esther Silk, Benjamin Davidson, Christopher B Pople, Agessandro Abrahao, Jill Hamilton, George M Ibrahim, Daniel J Müller, Peter Giacobbe, Nir Lipsman, Clement Hamani
The global prevalence of obesity increases yearly along with a rising demand for efficacious, safe, and accessible treatments. Neuromodulation interventions (i.e., deep brain stimulation [DBS], transcranial magnetic stimulation [TMS], transcranial direct current stimulation [tDCS], percutaneous neurostimulation [PENS], vagus nerve stimulation [VNS], and gastric electrical stimulation [GES]) have been proposed as novel therapies. This systematic review sought to examine the safety and efficacy of neuromodulation therapies in reducing body weight in patients with obesity...
October 2021: Obesity Reviews
#29
REVIEW
Ramey G Monem, Olaoluwa O Okusaga
Obesity is highly prevalent in patients with schizophrenia and, in association with metabolic syndrome, contributes to premature deaths of patients due to cardiovascular disease complications. Moreover, pharmacologic, and behavioral interventions have not stemmed the tide of obesity in schizophrenia. Therefore, novel effective interventions are urgently needed. Repetitive transcranial magnetic stimulation (rTMS) has shown efficacy for inducing weight loss in obese non-psychiatric samples but this promising intervention has not been evaluated as a weight loss intervention in patients with schizophrenia...
June 11, 2021: Behavioral Sciences
#30
REVIEW
Mark Immanuel Potes, Christian Joaquin, Nicole Wiecks, Sheshanna Phan, Omron Hassan
BACKGROUND: Deep brain stimulation (DBS) has demonstrated preliminary success as a treatment for neuropsychological disorders including obsessive-compulsive disorder and substance use disorder. This systematic review aims to assess the use of DBS in treating eating disorders (EDs) to determine its utility and the extent of adverse effects. METHODS: A PubMed search following PRISMA guidelines was executed to find studies encompassing DBS as a treatment of ED. Outcomes were extracted from the literature and summarized while a review of quality was also performed...
2021: Surgical Neurology International
#31
JOURNAL ARTICLE
Bing-Yan Zeng, Bing-Syuan Zeng, Yen-Wen Chen, Chao-Ming Hung, Cheuk-Kwan Sun, Yu-Shian Cheng, Brendon Stubbs, Andre F Carvalho, Andre R Brunoni, Kuan-Pin Su, Yu-Kang Tu, Yi-Cheng Wu, Tien-Yu Chen, Pao-Yen Lin, Chih-Sung Liang, Chih-Wei Hsu, Ping-Tao Tseng, Cheng-Ta Li
BACKGROUND/OBJECTIVES: Obesity has recently been recognized as a neurocognitive disorder involving circuits associated with the reward system and the dorsolateral prefrontal cortex (DLPFC). Noninvasive brain stimulation (NIBS) has been proposed as a strategy for the management of obesity. However, the results have been inconclusive. The aim of the current network meta-analysis (NMA) was to evaluate the efficacy and acceptability of different NIBS modalities for weight reduction in participants with obesity...
August 2021: International Journal of Obesity
#32
JOURNAL ARTICLE
Vinata Vedam-Mai, Karl Deisseroth, James Giordano, Gabriel Lazaro-Munoz, Winston Chiong, Nanthia Suthana, Jean-Philippe Langevin, Jay Gill, Wayne Goodman, Nicole R Provenza, Casey H Halpern, Rajat S Shivacharan, Tricia N Cunningham, Sameer A Sheth, Nader Pouratian, Katherine W Scangos, Helen S Mayberg, Andreas Horn, Kara A Johnson, Christopher R Butson, Ro'ee Gilron, Coralie de Hemptinne, Robert Wilt, Maria Yaroshinsky, Simon Little, Philip Starr, Greg Worrell, Prasad Shirvalkar, Edward Chang, Jens Volkmann, Muthuraman Muthuraman, Sergiu Groppa, Andrea A Kühn, Luming Li, Matthew Johnson, Kevin J Otto, Robert Raike, Steve Goetz, Chengyuan Wu, Peter Silburn, Binith Cheeran, Yagna J Pathak, Mahsa Malekmohammadi, Aysegul Gunduz, Joshua K Wong, Stephanie Cernera, Wei Hu, Aparna Wagle Shukla, Adolfo Ramirez-Zamora, Wissam Deeb, Addie Patterson, Kelly D Foote, Michael S Okun
We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the field...
2021: Frontiers in Human Neuroscience
#33
RANDOMIZED CONTROLLED TRIAL
Anna Ferrulli, Lorenzo Drago, Sara Gandini, Stefano Massarini, Federica Bellerba, Pamela Senesi, Ileana Terruzzi, Livio Luzi
Growing evidence highlights the crucial role of gut microbiota in affecting different aspects of obesity. Considering the ability of deep transcranial magnetic stimulation (dTMS) to modulate the cortical excitability, the reward system, and, indirectly, the autonomic nervous system (ANS), we hypothesized a potential role of dTMS in affecting the brain-gut communication pathways, and the gut microbiota composition in obesity. In a hospital setting, 22 subjects with obesity (5 M, 17 F; 44.9 ± 2.2 years; BMI 37...
April 29, 2021: International Journal of Molecular Sciences
#34
RANDOMIZED CONTROLLED TRIAL
Francantonio Devoto, Anna Ferrulli, Laura Zapparoli, Stefano Massarini, Giuseppe Banfi, Eraldo Paulesu, Livio Luzi
BACKGROUND AND AIMS: Deep repetitive Transcranial Magnetic Stimulation (deep rTMS) over the bilateral insula and prefrontal cortex (PFC) can promote weight-loss in obesity, preventing cardiometabolic complications as Type 2 Diabetes (T2D). To investigate the changes in the functional brain integration after dTMS, we conducted a resting-state functional connectivity (rsFC) study in obesity. METHODS AND RESULTS: This preliminary study was designed as a randomized, double-blind, sham-controlled study: 9 participants were treated with high-frequency stimulation (realTMS group), 8 were sham-treated (shamTMS group)...
June 7, 2021: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
#35
JOURNAL ARTICLE
Bina Kakusa, Yuhao Huang, Daniel A N Barbosa, Austin Feng, Sandra Gattas, Rajat Shivacharan, Eric B Lee, Fiene M Kuijper, Sabir Saluja, Jonathon J Parker, Kai J Miller, Corey Keller, Cara Bohon, Casey H Halpern
The availability of enticing sweet, fatty tastes is prevalent in the modern diet and contribute to overeating and obesity. In animal models, the subthalamic area plays a role in mediating appetitive and consummatory feeding behaviors, however, its role in human feeding is unknown. We used intraoperative, subthalamic field potential recordings while participants (n = 5) engaged in a task designed to provoke responses of taste anticipation and receipt. Decreased subthalamic beta-band (15-30 Hz) power responses were observed for both sweet-fat and neutral tastes...
July 2021: Neurobiology of Disease
#36
JOURNAL ARTICLE
Weibin He, Hongxia Li, Yijie Lai, Yunhao Wu, Yiwen Wu, Adolfo Ramirez-Zamora, Wei Yi, Chencheng Zhang
Purpose: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an effective treatment method for advanced Parkinson's disease (PD) and isolated dystonia and provides marked improvement of major motor symptoms. In addition, non-motor effects have been reported including weight gain (WG) in patients with PD after STN-DBS. However, it is still unclear whether patients with isolated dystonia also experience WG. Methods: Data from 47 patients with isolated dystonia who underwent bilateral STN-DBS surgery between October 2012 and June 2019 were retrospectively collected...
2021: Frontiers in Neurology
#37
JOURNAL ARTICLE
Marta Casquero-Veiga, Clara Bueno-Fernandez, Diego Romero-Miguel, Nicolás Lamanna-Rama, Juan Nacher, Manuel Desco, María Luisa Soto-Montenegro
Deep brain stimulation (DBS) is a powerful neurostimulation therapy proposed for the treatment of several neuropsychiatric disorders. However, DBS mechanism of action remains unclear, being its effects on brain dynamics of particular interest. Specifically, DBS reversibility is a major point of debate. Preclinical studies in obesity showed that the stimulation of the lateral hypothalamus (LH) and nucleus accumbens (NAcc), brain centers involved in satiety and reward circuits, are able to modulate the activity of brain structures impaired in this pathology...
March 10, 2021: Scientific Reports
#38
JOURNAL ARTICLE
Rachel S Gross, Akhgar Ghassabian, Sarvenaz Vandyousefi, Mary Jo Messito, Chongjing Gao, Kurunthachalam Kannan, Leonardo Trasande
Persistent organic pollutants (POPs) are believed to alter metabolic homeostasis during fetal development, leading to childhood obesity. However, limited studies have explored how fetal chemical exposures relate to birth and infant weight outcomes in low-income Hispanic families at the highest risk of obesity. Therefore, we sought to determine associations between neonatal POPs exposure measured in newborn dried blood spots (DBS) and prenatal diet quality, birth weight, and overweight status at 18 months old...
December 2020: Environmental Pollution
#39
JOURNAL ARTICLE
D L Marinus Oterdoom, Renske Lok, André P van Beek, Wilfred F A den Dunnen, Marloes Emous, J Marc C van Dijk, Gertjan van Dijk
Binge eating disorder (BED), with its compulsive and addictive components, may often underlie weight regain after gastrointestinal bariatric surgeries. BED is therefore considered an exclusion criterion for these surgeries. Anecdotal reports suggest that deep brain stimulation (DBS) is an effective treatment for addictive disorders with, similar to BED, pathological changes in cerebral reward circuitry. We therefore assessed effect of DBS of the nucleus accumbens (NAC) in a rat model of BED. Twenty-one male obesity prone Wistar rats with DBS electrodes placed in NAC subregions were subjected to a binge eating protocol...
October 2020: Obesity Surgery
#40
JOURNAL ARTICLE
Emily R Weichart, Per B Sederberg, Francesco Sammartino, Vibhor Krishna, John D Corrigan, Ali R Rezai
Device titration is a major challenge when using deep brain stimulation (DBS) to treat behavioral disorders. Unlike in movement disorders, there is no reliable real-time clinical feedback for changes in complex behaviors resulting from DBS. Here, a female patient receiving DBS of the nucleus accumbens for the treatment of morbid obesity underwent cognitive testing via the flanker task alongside traditional methods of device titration. One set of stimulation parameters administered during titration resulted in acute cognitive improvement (p = 0...
2020: Frontiers in Psychiatry
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
