Andres M Lozano, Lisa Fosdick, M Mallar Chakravarty, Jeannie-Marie Leoutsakos, Cynthia Munro, Esther Oh, Kristen E Drake, Christopher H Lyman, Paul B Rosenberg, William S Anderson, David F Tang-Wai, Jo Cara Pendergrass, Stephen Salloway, Wael F Asaad, Francisco A Ponce, Anna Burke, Marwan Sabbagh, David A Wolk, Gordon Baltuch, Michael S Okun, Kelly D Foote, Mary Pat McAndrews, Peter Giacobbe, Steven D Targum, Constantine G Lyketsos, Gwenn S Smith
BACKGROUND: Deep brain stimulation (DBS) is used to modulate the activity of dysfunctional brain circuits. The safety and efficacy of DBS in dementia is unknown. OBJECTIVE: To assess DBS of memory circuits as a treatment for patients with mild Alzheimer's disease (AD). METHODS: We evaluated active "on" versus sham "off" bilateral DBS directed at the fornix-a major fiber bundle in the brain's memory circuit-in a randomized, double-blind trial (ClinicalTrials...
September 6, 2016: Journal of Alzheimer's Disease: JAD