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bone resorption

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https://www.readbyqxmd.com/read/29331906/strontium-hydroxyapatite-scaffolds-engineered-with-stem-cells-aid-osteointegration-and-osteogenesis-in-osteoporotic-sheep-model
#1
Sunitha Chandran, Sachin J Shenoy, Suresh Babu S, Renjith P Nair, Varma H K, Annie John
Osteoporotic fracture healing is an orthopaedic challenge due to excessive bone resorption and impaired osteogenesis. Majority of current treatment strategies focus on regulating bone resorption and the potential application of Mesenchymal Stem Cells (MSCs) in promoting osteogenesis has not been explored much. Furthermore, the present study has put forth a novel approach, wherein the synergistic action of Strontium (Sr) and MSCs in a single implant may facilitate osteoporotic bone healing. Strontium Hydroxyapatite (SrHA) synthesized by wet precipitation was fabricated into tissue engineered Strontium incorporated Hydroxyapatite (cSrHA) using sheep adipose tissue derived MSCs (ADMSCs)...
December 28, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29331302/bone-matrix-microdamage-and-vascular-changes-characterize-bone-marrow-lesions-in-the-subchondral-bone-of-knee-osteoarthritis
#2
Dzenita Muratovic, David M Findlay, Flavia M Cicuttini, Anita E Wluka, Yea-Rin Lee, Julia S Kuliwaba
INTRODUCTION: Bone marrow lesions (BMLs) in the subchondral bone in osteoarthritis (OA) are suggested to be multifactorial, although the pathogenic mechanisms are unknown. Bone metabolism and cardiovascular risk factors associate with BML in epidemiologic studies. However, there are no studies at the tissue level investigating the relationship between these processes and BML. The aim of this study was to investigate the relationship between BMLs in the tibial plateau (TP) of knee OA and bone matrix microdamage, osteocyte density and vascular changes...
January 10, 2018: Bone
https://www.readbyqxmd.com/read/29331289/titanium-scaffolding-an-innovative-modality-for-salvage-of-failed-first-ray-procedures
#3
Natalie Coriaty, Katherine Pettibone, Nicholas Todd, Shannon Rush, Ryan Carter, Colin Zdenek
Shortening of the first ray is a potential complication associated with first metatarsal procedures. Correction of this deformity conventionally has required the use of a tricortical bone graft to lengthen the bone. Graft complications, including donor site morbidity, poor graft stability, and graft resorption, have revealed a need for an alternative procedure. The present report shows that titanium cage scaffolding has lower extremity applications beyond its previous uses in the ankle and spine. Two patients underwent surgical correction for failed first ray procedures using a titanium cage apparatus with a calcaneal autograft and other biologic agents...
January 11, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29330841/delayed-replantation-of-an-avulsed-immature-permanent-incisor-and-apexification-using-a-novel-fast-setting-calcium-silicate-cement-containing-fluoride-a-3-year-follow-up-case-report
#4
A Vafaei, B Ranjkesh, L Erfanparast, H Løvschall
BACKGROUND: Traumatic tooth avulsion requires an urgent intervention to replant the tooth. Prolonged post-injury dry extra-oral conditions worsen the prognosis and increase the risk of root resorption. Fluoride has the potential to delay replacement resorption. Calcium silicate cements (CSC) are used to seal the root canal system and to stimulate periapical regeneration in immature open apex teeth (apexification). This report suggests the application of a novel fast-setting CSC with fluoride for apexification in an attempt to hinder root resorption...
January 12, 2018: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29330573/tocotrienol-supplementation-suppressed-bone-resorption-and-oxidative-stress-in-postmenopausal-osteopenic-women-a-12-week-randomized-double-blinded-placebo-controlled-trial
#5
C-L Shen, S Yang, M D Tomison, A W Romero, C K Felton, H Mo
Tocotrienols have shown bone-protective effect in animals. This study showed that a 12-week tocotrienol supplementation decreased concentrations of bone resorption biomarker and bone remodeling regulators via suppressing oxidative stress in postmenopausal osteopenic women. INTRODUCTION: Tocotrienols (TT) have been shown to benefit bone health in ovariectomized animals, a model of postmenopausal women. The purpose of this study was to evaluate the effect of 12-week TT supplementation on bone markers (serum bone-specific alkaline phosphatase (BALP), urine N-terminal telopeptide (NTX), serum soluble receptor activator of nuclear factor-kappaB ligand (sRANKL), and serum osteoprotegerin (OPG)), urine calcium, and an oxidative stress biomarker (8-hydroxy-2'-deoxyguanosine (8-OHdG)) in postmenopausal women with osteopenia...
January 12, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29329805/preparative-expression-and-purification-of-a-nacreous-protein-n16-and-testing-its-effect-on-osteoporosis-rat-model
#6
Zhen-Yan Xu, Yu-Ling Liu, Jia-Bi Lin, Ke-Ling Cheng, Yong-Gang Wang, Hong-Liang Yao, Wei-Peng, Hoi-Yan Wu, Wei-Wei Su, Pang-Chui Shaw, Pei-Bo Li
N16, a nacreous protein isolated from Pinctada martensii, is related to nacreous layer formation. Our previous study indicated that N16 showed dual regulatory effects by inducing osteoblast biomineralization as well as inhibiting osteoclast formation. In order to obtain large quantity of N16 for animal experiment and clinical trial, a fermentation and preparative purification method was established. The N16 cDNA was cloned to a BL21(DE3)plysE-pET32a vector and grown in a 20 L fermenter. The medium, temperature, pH and dissolved oxygen (DO) were optimized...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29329716/gelatin-hydroxyapatite-calcium-sulphate-based-biomaterial-for-long-term-sustained-delivery-of-bone-morphogenic-protein-2-and-zoledronic-acid-for-increased-bone-formation-in-vitro-and-in-vivo-carrier-properties
#7
Deepak Bushan Raina, David Larsson, Filip Mrkonjic, Hanna Isaksson, Ashok Kumar, Lars Lidgren, Magnus Tägil
In this study, a novel macroporous composite biomaterial consisting of gelatin-hydroxyapatite-calcium sulphate for delivery of bone morphogenic protein-2 (rhBMP-2) and zoledronic acid (ZA) has been developed. The biomaterial scaffold has a porous structure and functionalization of the scaffold with rhBMP-2 induces osteogenic differentiation of MC3T3-e1 cells seen by a significant increase in biochemical and genetic markers of osteoblastic differentiation. In-vivo muscle pouch experiments showed higher mineralization using scaffold+rhBMP-2 when compared to an approved absorbable collagen sponge (ACS)+rhBMP-2 as verified by micro-CT...
January 9, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29328885/radiographic-emphysema-circulating-bone-biomarkers-and-progressive-bone-mineral-density-loss-in-smokers
#8
Jessica Bon, Yingze Zhang, Joseph K Leader, Carl Fuhrman, Subashan Perera, Divay Chandra, Marnie Bertolet, Brenda Diergaarde, Susan L Greenspan, Frank C Sciurba
RATIONALE: Osteoporosis is common in individuals with chronic obstructive pulmonary disease. Lung-specific factors, including radiographic emphysema, independently associate with low bone mineral density (BMD) in cross-sectional smoking cohorts. However, factors associated with progressive bone loss in smokers are under-studied and largely unknown. OBJECTIVES: To determine the relationship between radiographic emphysema, circulating bone metabolism markers, and pulmonary function and accelerated BMD loss in smokers...
January 12, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29327779/locally-delivered-ethyl-2-5-dihydroxybenzoate-using-3d-printed-bone-implant-for-promotion-of-bone-regeneration-in-a-osteoporotic-animal-model
#9
B-J Kwon, G M Seon, M H Lee, M-A Koo, M S Kim, D Kim, J-J Han, D Kim, J Kim, J-C Park
Osteoporosis is a disease characterized by low bone mass, most commonly caused by an increase in bone resorption that is not matched by sufficient bone formation. The most common complications of postmenopausal osteoporosis are bone-related defects and fractures. Fracture healing is a multifactorial bone regeneration process, influenced by both biological and mechanical factors related to age, osteoporosis and stability of the osteosynthesis. During the treatment of bone defects in osteoporotic conditions, imbalanced bone remodeling is the leading cause for implant failure...
January 12, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29325187/in-vivo-evaluation-of-biodegradability-and-biocompatibility-of-fe30mn-alloy
#10
Marine Traverson, Michael Heiden, Lia A Stanciu, Eric A Nauman, Yava Jones-Hall, Gert J Breur
OBJECTIVES:  This study aims to evaluate the biodegradability and biocompatibility of an alloy of iron and manganese (Fe30Mn) in a bone model in vivo. METHODS:  Resorption of a Fe30Mn wire was compared with traditional permanent 316L stainless steel (SS) wire after bilateral transcondylar femoral implantation in 12 rats. Evaluation of biodegradation over 6 months was performed using radiography, post-mortem histology and microscopic implant surface analysis...
January 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29323724/autoregulation-of-rank-ligand-in-oral-squamous-cell-carcinoma-tumor-cells
#11
Yuvaraj Sambandam, Purushoth Ethiraj, Jessica Hathway-Schrader, Chad Novince, Ezhil Panneerselvam, Kumaran Sundaram, Sakamuri V Reddy
Oral squamous cell carcinoma (OSCC) is the most common malignancy among oral cancers and shows potent activity for local bone invasion. Receptor activator of nuclear factor κB (RANK) ligand (RANKL) is critical for bone-resorbing osteoclast formation. We previously demonstrated that OSCC tumor cells express high levels of RANKL. In this study, confocal microscopy demonstrated RANKL specific receptor, RANK expression in OSCC tumor cell lines (SCC1, SCC12 and SCC14a). We also confirmed the expression of RANK and RANKL in primary human OSCC tumor specimens...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29322325/histochemical-evidence-of-igf2-mrna-binding-protein-2-mediated-regulation-of-osteoclast-function-and-adhesive-ability
#12
Hongrui Liu, Dongfang Li, Shanshan Liu, Zhaopeng Liu, Minqi Li
Insulin-like growth factor 2 (IGF2) messenger RNA-binding proteins (IMPs) are a family of oncofetal RNA-binding proteins that play important roles in cell migration, renewal, and metabolism. IMP2 gene expression may be important in determining IGF2 levels and might, thereby, be central to bone metabolism. In our present study, IMP2-deficient mice exhibited more immature bone structures, characterized by abundant residual cartilage cores; growth plates containing more rich cartilage matrix, which was arranged irregularly; and a significantly thicker hypertrophic chondrocyte layer in the femoral metaphysis, compared with wild-type mice...
January 10, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29321271/incremental-distribution-of-strontium-and-zinc-in-great-ape-and-fossil-hominin-cementum-using-synchrotron-x-ray-fluorescence-mapping
#13
Christopher Dean, Adeline Le Cabec, Kathryn Spiers, Yi Zhang, Jan Garrevoet
Cementum and the incremental markings it contains have been widely studied as a means of ageing animals and retrieving information about diet and nutrition. The distribution of trace elements in great ape and fossil hominin cementum has not been studied previously. Synchrotron X-ray fluorescence (SXRF) enables rapid scanning of large tissue areas with high resolution of elemental distributions. First, we used SXRF to map calcium, phosphorus, strontium and zinc distributions in great ape dentine and cementum...
January 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29319546/influence-of-the-presence-of-alveolar-mucosa-at-implants-a-histological-study-in-humans
#14
Yasushi Nakajima, Adriano Piattelli, Giovanna Iezzi, Natalia Fortich Mesa, Mauro Ferri, Daniele Botticelli
OBJECTIVE: To evaluate the influence of the presence or absence of keratinized mucosa on hard and soft tissues around implants. MATERIAL AND METHODS: Sixteen volunteers with edentulous regions in the distal aspect of the mandible participated in the study. In each patient, 2 solid titanium screw-shaped devices, 3.5 mm in diameter and 5 mm long, were installed. The incision of the mucosa was performed in such a way to allow that, after the suture of the flaps, only the alveolar mucosa surround the test sites and the keratinized mucosa surround the control implants...
January 9, 2018: Implant Dentistry
https://www.readbyqxmd.com/read/29319378/nonhealing-orbital-floor-fracture-in-a-pediatric-patient-a-unique-presentation-of-pseudo-silent-sinus-syndrome
#15
Siwei Zhou, Katherine Duncan, S Tonya Stefko
Silent sinus syndrome was first described as spontaneous enophthalmos and hypoglobus associated with subclinical maxillary sinusitis without prior trauma or surgery. This clinical entity has later been described after trauma in which damage to the ostiomeatal complex leads to atelectasis of the maxillary sinus. We report a case of a 14-year-old boy who presented 4 years after sustaining a non-operative orbital floor fracture with enophthalmos and transient diplopia. Computed tomography (CT) demonstrated enlargement in size of the original orbital floor fracture and bilateral maxillary sinus disease...
January 10, 2018: Orbit
https://www.readbyqxmd.com/read/29318649/treatment-related-changes-in-bone-turnover-and-fracture-risk-reduction-in-clinical-trials-of-anti-resorptive-drugs-a-meta-regression
#16
Douglas C Bauer, Dennis M Black, Mary L Bouxsein, Li-Yung Lui, Jane A Cauley, Anne E de Papp, Andreas Grauer, Sundeep Khosla, Charles E McCulloch, Richard Eastell
Few pooled analyses of antiresorptive (AR) treatment trials relate short-term changes in bone turnover markers (BTMs) to subsequent fracture reduction. Such information would be useful to assess new ARs or novel dosing regimens. In the Foundation for the National Institutes of Health (FNIH) Bone Quality project, we analyzed individual-level data from 28,000 participants enrolled in 11 bisphosphonate (BP) and three selective estrogen receptor modulator (SERM) placebo-controlled fracture endpoint trials. Using BTM results for two bone formation markers (bone-specific alkaline phosphatase [bone ALP] and pro-collagen I N-propeptide [PINP]) and two bone resorption markers (N-terminal and C-terminal telopeptide of type I collagen) and incident fracture outcome data, we performed a meta-regression relating the mean net effect of treatment on change in bone turnover (active minus placebo % difference after 3 to 12 months) to the log of study-wide fracture risk reduction, and used linear regression to plot the best fitting line...
January 10, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29318392/relationship-between-melatonin-and-bone-resorption-rhythms-in-premenopausal-women
#17
Melissa A St Hilaire, Shadab A Rahman, Joshua J Gooley, Paula A Witt-Enderby, Steven W Lockley
Although evidence exists for a daily rhythm in bone metabolism, the contribution of factors such as melatonin levels, the light-dark cycle, and the sleep-wake cycle is difficult to differentiate given their highly correlated time courses. To examine these influences on bone resorption, we collected 48-h sequential urine samples under both ambulatory (8-h sleep:16-h wake) and constant routine (CR) (constant wake, posture, nutrition and dim light) conditions from 20 healthy premenopausal women. Urinary 6-sulphatoxymelatonin (aMT6s; ng/h) and the bone resorption marker amino-terminal cross-linked collagen I telopeptide (NTx; bone collagen equivalents nM/h) were assayed and fit by cosinor models to determine significant 24-h rhythms and acrophase...
January 9, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29318379/osteoinduction-and-conduction-through-absorbable-bone-substitute-materials-based-on-calcium-sulfate-in-vivo-biological-behavior-in-a-rabbit-model
#18
D Pförringer, N Harrasser, H Mühlhofer, M Kiokekli, A Stemberger, M van Griensven, M Lucke, R Burgkart, A Obermeier
Calcium sulfate (CS) can be used as an antibiotically impregnated bone substitute in a variety of clinical constellations. Antibiotically loaded bone substitutes find specific application in orthopedic and trauma surgery to prevent or treat bone infections especially in relation to open bone defects. However, its use as a structural bone graft reveals some concerns due to its fast biodegradation. The addition of calcium carbonate and tripalmitin makes CS formulations more resistant to resorption leaving bone time to form during a prolonged degradation process...
January 9, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29317698/occlusal-disharmony-induced-stress-causes-osteopenia-of-the-lumbar-vertebrae-and-long-bones-in-mice
#19
Yasuhiro Shimizu, Masud Khan, Genki Kato, Kazuhiro Aoki, Takashi Ono
Excessive exposure to glucocorticoids causes osteoporosis in children and adults. Occlusal disharmony is known to induce an increase in serum corticosteroid levels in murine models, but the influence of occlusal disharmony-induced stress on the bone mass during the growth period has not yet been clarified. The purpose of this study was to investigate whether occlusal disharmony-induced stress decreases bone mass. Five-week-old C57BL/6J male mice were used. A 0.5-mm increase in the vertical height of occlusion was used to induce occlusal disharmony for a period of 7 days...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317302/bu-shen-tong-luo-decoction-prevents-bone-loss-via-inhibition-of-bone-resorption-and-enhancement-of-angiogenesis-in-ovariectomy-induced-osteoporosis-of-rats
#20
Han Yuan, Linyan Xiao, Wen Min, Wenchao Yuan, Shengfeng Lu, Guicheng Huang
ETHNOPHARMACOLOGICAL RELEVANCE: Gathering three ancient formulas, traditional Chinese medicine Bu-Shen-Tong-Luo decoction (BSTLD) has been used to treat postmenopausal osteoporosis (PMO) at the Jiangsu Province Hospital of Chinese Medicine for decades. However, the effect of BSTLD on angiogenesis and bone resorption as well as its possible mechanism are still unknown. AIM OF THE STUDY: This study was aimed to evaluate the preventive effect of BSTLD on ovariectomy-induced bone loss and vasculature disorder, and to investigate the possible bone protection mechanism of BSTLD in inhibiting bone resorption by enhancing angiogenesis signaling in ovariectomy-induced osteoporosis of rats...
January 6, 2018: Journal of Ethnopharmacology
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