keyword
https://read.qxmd.com/read/38526212/relative-contributions-of-osteal-macrophages-and-osteoclasts-to-postnatal-bone-development-in-csf1r-deficient-rats-and-phenotype-rescue-following-wild-type-bone-marrow-cell-transfer
#21
JOURNAL ARTICLE
Lena Batoon, Sahar Keshvari, Katharine M Irvine, Eileen Ho, Melanie Caruso, Omkar L Patkar, Anuj Sehgal, Susan M Millard, David A Hume, Allison R Pettit
Macrophage and osteoclast proliferation, differentiation and survival are regulated by colony-stimulating factor-1 receptor (CSF1R) signaling. Osteopetrosis associated with Csf1 and Csf1r mutations has been attributed to the loss of osteoclasts and deficiency in bone resorption. Here we demonstrate that homozygous Csf1r mutation in rat leads to delayed postnatal skeletal ossification associated with substantial loss of osteal macrophages (osteomacs) in addition to osteoclasts. Osteosclerosis and site-specific skeletal abnormalities were reversed by intraperitoneal transfer of wild-type bone marrow cells (BMT) at weaning...
March 25, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38524193/load-transfer-in-bone-after-partial-multi-compartmental-and-total-knee-arthroplasty
#22
JOURNAL ARTICLE
Jennifer C Stoddart, Amy Garner, Mahmut Tuncer, Andrew A Amis, Justin Cobb, Richard J van Arkel
Introduction: Arthroplasty-associated bone loss remains a clinical problem: stiff metallic implants disrupt load transfer to bone and, hence, its remodeling stimulus. The aim of this research was to analyze how load transfer to bone is affected by different forms of knee arthroplasty: isolated partial knee arthroplasty (PKA), compartmental arthroplasty [combined partial knee arthroplasty (CPKA), two or more PKAs in the same knee], and total knee arthroplasty (TKA). Methods: An experimentally validated subject-specific finite element model was analyzed native and with medial unicondylar, lateral unicondylar, patellofemoral, bi-unicondylar, medial bicompartmental, lateral bicompartmental, tricompartmental, and total knee arthroplasty...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38523666/demographic-and-disease-related-factors-impact-bone-turnover-and-vitamin-d-in-children-with-hemato-oncological-diseases
#23
JOURNAL ARTICLE
Natalja Jackmann, Jan Gustafsson, Pauliina Utriainen, Per Magnusson, Arja Harila, Diana Atanasova, Carina Rinaldo, Per Frisk, Outi Mäkitie
Children with hemato-oncological diseases may have significant skeletal morbidity, not only during and after treatment but also at the time of diagnosis before cancer treatment. This study was designed to evaluate the vitamin D status and circulating bone metabolic markers and their determinants in children at the time of diagnostic evaluation for hemato-oncological disease. This cross-sectional study included 165 children (91 males, median age 6.9 yr range 0.2-17.7 yr). Of them, 76 patients were diagnosed with extracranial or intracranial solid tumors, 83 with leukemia, and 6 with bone marrow failure...
April 2024: JBMR Plus
https://read.qxmd.com/read/38522564/morusin-inhibits-breast-cancer-induced-osteolysis-by-decreasing-phosphatidylinositol-3-kinase-pi3k-mtor-signalling
#24
JOURNAL ARTICLE
Long Zhang, Weibin Li, Xiaohui Chen, Dongmin Cao, Siyuan You, Fan Shi, Zhengqiong Luo, Hongyu Li, Xiangchen Zeng, Yabin Song, Na Li, Yoshie Akimoto, Gang Rui, Yu Chen, Zuoxing Wu, Ren Xu
Bone metastases caused by breast cancer pose a major challenge to the successful treatment of breast cancer patients. Many researchers have suggested that herbal medicines are extremely effective at preventing and treating cancer-associated osteolysis. Previous studies have revealed that Morusin (MOR) is cytotoxic to many cancer cells ex vivo. Nevertheless, how MOR contributes to osteolysis induced by breast cancer is still unknown, and the potential mechanism of action against osteolysis is worthy of further study...
March 22, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38522327/membrane-anchoring-selenophene-viologens-for-antibacterial-photodynamic-therapy-against-periodontitis-via-restoring-subgingival-flora-and-alleviating-inflammation
#25
JOURNAL ARTICLE
Rui Ding, Xu Liu, Xiaodan Zhao, Qi Sun, Yilong Cheng, Ang Li, Dandan Pei, Gang He
Antibacterial photodynamic therapy (aPDT) has emerged as a promising strategy for treating periodontitis. However, the weak binding of most photosensitizers to bacteria and the hypoxic environment of periodontal pockets severely hamper the therapeutic efficacy. Herein, two novel oxygen-independent photosensitizers are developed by introducing selenophene into viologens and modifying with hexane chains (HASeV) or quaternary ammonium chains (QASeV), which improve the adsorption to bacteria through anchoring to the negatively charged cell membrane...
March 21, 2024: Biomaterials
https://read.qxmd.com/read/38521741/evaluating-changes-in-the-condylar-head-after-orthognathic-surgery-with-or-without-articular-disc-repositioning-a-systematic-review
#26
REVIEW
Luís Eduardo Charles Pagotto, Everton Freitas de Morais, Thiago de Santana Santos, Gabriel Pires Pastore
Failures in orthognathic surgery are associated with different factors, including those related to untreated or undiagnosed preoperative temporomandibular joint (TMJ) disorders. This systematic review aimed to assess potential alterations in the condylar head following orthognathic surgery. A systematic search for randomised controlled trials and retrospective studies was performed. For inclusion in the review, studies had to meet the following eligibility criteria according to the PICO framework: Patients: patients with orthognathic deformity and temporomandibular dysfunction (or temporomandibular osteoarthritis); Intervention: patients submitted to orthognathic surgery concomitantly with TMJ disjunction; Control: patients undergoing only orthognathic surgery with or without presurgical data; and Outcome: changes in temporomandibular joint position and volume...
January 14, 2024: British Journal of Oral & Maxillofacial Surgery
https://read.qxmd.com/read/38521429/orcinol-gentiobioside-inhibits-rankl-induced-osteoclastogenesis-by-promoting-apoptosis-and-suppressing-autophagy-via-the-jnk1-signaling
#27
JOURNAL ARTICLE
Chenxia Lian, Wan Gong, Xuan Zhao, Peng Sun, Sijing Hu, Guifen Zhou, Qiaoyan Zhang, Luping Qin
ETHNOPHARMACOLOGICAL RELEVANCE: Osteoporosis is a metabolic disorder characterizecby disrupted osteoclastic bone resorption and osteoblastic bone formation. Curculigo orchioides Gaertn has a long history of application in traditional Chinese and Indian medicine for treating OP. Orcinol gentiobioside (OGB) is a principal active constituent derived from Curculigo orchioides Gaertn and has been shown to have anti-OP activity. However, the therapeutic efficacy and mechanism of OGB in modulating osteoclastic bone resorption remain undefined...
March 21, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38520665/porous-versus-solid-shoulder-implants-in-humeri-of-different-bone-densities-a-finite-element-analysis
#28
JOURNAL ARTICLE
Sydney Hitchon, Pendar Soltanmohammadi, Jaques S Milner, David Holdsworth, Ryan Willing
Porous metallic prosthesis components can now be manufactured using additive manufacturing techniques, and may prove beneficial for promoting bony ingrowth, for accommodating drug delivery systems, and for reducing stress shielding. Using finite element modeling techniques, 36 scenarios (three porous stems, three bone densities, and four held arm positions) were analysed to assess the viability of porous humeral stems for use in total shoulder arthroplasty, and their resulting mechanobiological impact on the surrounding humerus bone...
March 23, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38520382/high-dose-vitamin-d-to-attenuate-bone-loss-in-patients-with-prostate-cancer-on-androgen-deprivation-therapy-a-phase-2-rct
#29
JOURNAL ARTICLE
Luke J Peppone, Amber S Kleckner, Chunkit Fung, J Edward Puzas, Jennifer E Reschke, Eva Culakova, Julia Inglis, Charles Kamen, Jonathan W Friedberg, Michelle Janelsins, Karen Mustian, Charles E Heckler, Supriya Mohile
BACKGROUND: Androgen deprivation therapy (ADT) inhibits prostate cancer growth. However, ADT causes loss of bone mineral density (BMD) and an increase in fracture risk; effective interventions for ADT-induced bone loss are limited. METHODS: A phase 2 randomized controlled trial investigated the feasibility, safety, and preliminary efficacy of high-dose weekly vitamin D (HDVD, 50,000 IU/week) versus placebo for 24 weeks in patients with prostate cancer receiving ADT, with all subjects receiving 600 IU/day vitamin D and 1000 mg/day calcium...
March 23, 2024: Cancer
https://read.qxmd.com/read/38519718/oestradiol-and-osteoclast-differentiation-effects-on-p53-and-mitochondrial-metabolism
#30
JOURNAL ARTICLE
Adriana Marques-Carvalho, Beatriz Silva, Francisco B Pereira, Ha-Neui Kim, Maria Almeida, Vilma A Sardão
BACKGROUND: Oestrogen deficiency increases bone resorption, contributing to osteoporosis development. Yet, the mechanisms mediating the effects of oestrogen on osteoclasts remain unclear. This study aimed to elucidate the early metabolic alteration induced by RANKL, the essential cytokine in osteoclastogenesis and 17-beta-oestradiol (E2 ) on osteoclast progenitor cells, using RAW 264.7 macrophage cell line and primary bone marrow-derived macrophages as biological models. RESULTS: This research demonstrated that, in osteoclast precursors, RANKL stimulates complex I activity, oxidative phosphorylation (OXPHOS) and mitochondria-derived ATP production as early as 3 h of exposure...
March 22, 2024: European Journal of Clinical Investigation
https://read.qxmd.com/read/38519378/does-early-administration-of-denosumab-delay-bone-healing-after-intertrochanteric-femoral-fractures
#31
JOURNAL ARTICLE
Masahito Hino, Manabu Tanaka, Fumiki Kamoi, Itsuo Joko, Kazuo Kasuga, Yoshinori Tsukahara, Jun Takahashi, Shigeharu Uchiyama
INTRODUCTION: Hip fractures are commonly associated with osteoporosis and pose a risk for secondary fractures. Although the administration of anti-osteoporotic drugs is recommended after fractures to mitigate this risk, the potential effect of strong anti-resorptive drugs (e.g., denosumab) on fracture healing processes have not been extensively studied. This prospective study aimed to evaluate the feasibility of early denosumab administration after femoral intertrochanteric fracture surgery and to compare its effect on fracture healing to that of bisphosphonate-treated patients...
March 21, 2024: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://read.qxmd.com/read/38517987/graft-resorption-after-posterior-distal-tibial-allograft-augmentation-for-posterior-shoulder-instability-a-case-report
#32
JOURNAL ARTICLE
Andrew Luzzi, Venkat Boddapati, Brandon L Rogalski, Michael L Knudsen, William N Levine, Charles M Jobin
CASE: A 19-year-old man underwent arthroscopic posterior glenoid reconstruction with a distal tibia allograft (DTA) after failing 2 posterior, soft-tissue instability surgeries. Although he experienced near-complete resolution of symptoms and return to sport, graft resorption was noted 7 months postoperatively. The patient underwent revision surgery for screw removal. CONCLUSION: Graft resorption has not previously been reported in the setting of arthroscopic DTA use for posterior instability...
January 1, 2024: JBJS Case Connector
https://read.qxmd.com/read/38516573/patterns-and-environmental-drivers-of-c-n-and-p-stoichiometry-in-the-leaf-litter-soil-system-associated-with-mongolian-pine-forests
#33
JOURNAL ARTICLE
Yue Ren, Guang-Lei Gao, Guo-Dong Ding, Ying Zhang, Pei-Shan Zhao
Ecological stoichiometry is an important approach to understand plant nutrient cycling and balance in the forest ecosystem. However, understanding of stoichiometric patterns through the leaf-litter-soil system of Mongolian pine among different stand origins is still scarce. Therefore, to reveal the variations in Mongolian pine carbon (C), nitrogen (N), and phosphorus (P) stoichiometry and stoichiometric homeostasis among different stand origins, we measured C, N, and P concentrations of leaves, litter, and soil, and analyzed the nutrient resorption efficiencies of leaves in differently aged plantations and natural forests from semi-arid and dry sub-humid regions...
March 2024: Ecology and Evolution
https://read.qxmd.com/read/38516438/ortho-endo-management-of-traumatically-intruded-immature-incisors-a-case-report-of-novel-interventional-approach-with-20-months-follow-up
#34
Raichel M Geevarghese, Ramanandvignesh Pandiyan, Sapna Singla, Manjit Talwar, Gurvanit Lehl
The case report describes the successful interdisciplinary management of a nine-year-old girl who suffered from traumatic intrusion and rotation of her immature teeth with 12 mm apical displacement of teeth 11 and 21 and 10 mm of teeth 12 and 22. It emphasizes the importance of a comprehensive and contemporary approach, which includes orthodontic intervention and regenerative endodontic procedures (REP). The report follows the CARE (case report) guidelines. The patient was initially observed for four weeks to see if there was potential for spontaneous re-eruption...
February 2024: Curēus
https://read.qxmd.com/read/38516117/evaluation-of-maxillary-transverse-dimensions-in-individuals-with-a-unilaterally-impacted-canine
#35
JOURNAL ARTICLE
Ibtisam A Alshalawi, Dalal M Alnahad, Husam I Ardah, Wael M Aboelmaaty, Najla S Alrejaye
INTRODUCTION: The aim of this study was to investigate the maxillary width within individuals with a unilaterally impacted maxillary canine and to determine any association between the impacted canine location and some canine-related variables. METHODS: A cross-sectional analytical study using a split-mouth design included 22 CBCTs of individuals with unilaterally impacted maxillary canines (a total of 44 sides). The maxillary width was measured and compared in both impacted and non-impacted sides at various levels: basal, alveolar, and dental...
2024: Journal of Orthodontic Science
https://read.qxmd.com/read/38515382/fetal-protective-effect-of-indonesian-propolis-from-apis-mellifera-against-rifampicin-pyrazinamide-induced-impaired-pregnancy-in-balb-c-mice
#36
JOURNAL ARTICLE
Rahmad Abdillah, Fitri Rachmaini, Dinda Fadhilah, Almahdy Almahdy
OBJECTIVE: Anti-tuberculosis drugs Rifampicin and Pyrazinamide combination in pregnancy can cause morphological, visceral and skeletal damage. Several studies showed that propolis improves pregnancy outcomes. This study aims to determine the fetal protective effect of propolis in BALB/c mice given the anti-tuberculosis drug combination Rifampicin and Pyrazinamide. METHODS: A total of 21 pregnant mice were randomly divided into three groups: the normal group (N) was given distilled water as a vehicle, the positive control group (RP) were given rifampicin 15 mg/kg BW, pyrazinamide 35 mg/kg BW and the treatment group (IP) were given rifampicin 15 mg/kg BB, pyrazinamide 35 mg/kg BW and propolis 400 mg/kg BW...
March 25, 2024: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/38515258/c-terminal-cross-linking-telopeptide-levels-in-covid-19-patients-a-prospective-case-control-study
#37
JOURNAL ARTICLE
Mehmet Ali Gul, Nezahat Kurt, Fatma Betul Ozgeris, Neslihan Yuce, Omer Faruk Kocak, Emine Parlak
BACKGROUND: Coronavirus disease 19 (COVID-19) is a viral infection mediated by coronavirus-2 that causes severe acute respiratory syndrome (SARS-CoV-2). The disease may affect biochemical parameters and electrolytes. C-terminal cross-linking telopeptide (CTX-I) is released during mature bone resorption and is a biomarker for predicting bone resorption. OBJECTIVES: As the pandemic progressed, understanding the effects of COVID-19 disease remained critical. Inflammatory responses triggered by the virus can result in a bone metabolism regulation imbalance...
March 21, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38515079/role-of-%C3%AE-enac-in-root-resorption-of-adjacent-teeth-due-to-entirely-impacted-mandibular-third-molars
#38
JOURNAL ARTICLE
Jiaqi Tang, Weijun Yu, Lu Lin, Ruhan Yang, Guanglong Li, Min Jin, Yuting Gu, Bin Jiang, Eryi Lu
BACKGROUND: Entirely impacted mandibular third molar (EIM3M) concerns the pathological external root resorption (ERR) of the adjacent mandibular second molar (M2M) and formation of granulation tissue between two molars. The study aimed to clarify the effect of αENaC, a mechano-sensitive molecule, to explore the mechanical mechanism in this scenario. METHODS: The force EIM3M exerted on M2M was proved by finite element analysis. αENaC expressions were tested by real-time polymerase chain reaction (PCR), immunoblotting and immunofluorescence...
March 21, 2024: BMC Oral Health
https://read.qxmd.com/read/38514644/%C3%AE-receptor-blocker-enhances-the-anabolic-effect-of-pth-after-osteoporotic-fracture
#39
JOURNAL ARTICLE
Jie Huang, Tong Wu, Yi-Rong Jiang, Xuan-Qi Zheng, Huan Wang, Hao Liu, Hong Wang, Hui-Jie Leng, Dong-Wei Fan, Wan-Qiong Yuan, Chun-Li Song
The autonomic nervous system plays a crucial role in regulating bone metabolism, with sympathetic activation stimulating bone resorption and inhibiting bone formation. We found that fractures lead to increased sympathetic tone, enhanced osteoclast resorption, decreased osteoblast formation, and thus hastened systemic bone loss in ovariectomized (OVX) mice. However, the combined administration of parathyroid hormone (PTH) and the β-receptor blocker propranolol dramatically promoted systemic bone formation and osteoporotic fracture healing in OVX mice...
March 21, 2024: Bone Research
https://read.qxmd.com/read/38513592/mebendazole-preferentially-inhibits-cilia-formation-and-exerts-anticancer-activity-by-synergistically-augmenting-dna-damage
#40
JOURNAL ARTICLE
Juyeon Hong, Keun Yeong Kwon, Dong Gil Jang, Taejoon Kwon, Haejin Yoon, Tae Joo Park
The cilium is a microtubule-based organelle that plays a pivotal role in embryonic development and maintenance of physiological functions in the human body. In addition to their function as sensors that transduce diverse extracellular signals, including growth factors, fluid flow, and physical forces, cilia are intricately involved in cell cycle regulation and preservation of DNA integrity, as their formation and resorption dynamics are tightly linked to cell cycle progression. Recently, several studies have linked defects in specific ciliary proteins to the DNA damage response...
March 20, 2024: Biomedicine & Pharmacotherapy
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