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thermo activated

Lovish Marwaha, Yashika Bansal, Raghunath Singh, Priyanka Saroj, Ranjana Bhandari, Anurag Kuhad
Neuropathic pain is a debilitating disease which affects central as well as peripheral nervous system. Transient receptor potential (TRP) channels are ligand-gated ion channels that detect physical and chemical stimuli and promote painful sensations via nociceptor activation. TRP channels have physiological role in the mechanisms controlling several physiological responses like temperature and mechanical sensations, response to painful stimuli, taste, and pheromones. TRP channel family involves six different TRPs (TRPV1, TRPV2, TRPV3, TRPV4, TRPM8, and TRPA1) which are expressed in pain sensing neurons and primary afferent nociceptors...
October 18, 2016: Inflammopharmacology
Chiara Peila, Nikki E Emmerik, Marzia Giribaldi, Bernd Stahl, Joost E Ruitenberg, Ruurd M van Elburg, Guido E Moro, Enrico Bertino, Alessandra Coscia, Laura Cavallarin
OBJECTIVES: Pasteurization, performed at 62.5°C for 30 min (holder pasteurization), is currently recommended in all international human milk banks guidelines, but it affects some human milk bioactive and nutritive components. The present systematic review is aimed at critically reviewing evidence on the suitability of human milk processing techniques other than holder pasteurization, both thermal and non-thermal, to ensure microbiological safety, and on the effects of these techniques on biologically active donor milk components...
October 13, 2016: Journal of Pediatric Gastroenterology and Nutrition
M A Sokoto, Rawel Singh, Bhavya B Krishna, Jitendra Kumar, Thallada Bhaskar
Thermal decomposition and kinetics behaviour of the de-oiled seed cake of African star apple (Chrosophyllum albidum) has been investigated using thermogravimetry under the nitrogen atmosphere from ambient temperature to 900 °C. The thermogravimetric data for the cake decomposition at six different heating rates (5, 10, 15, 20, 30 and 40 °C/min) were used to evaluate the kinetic decomposition of the cake using Friedman (FD), Kissinger-Akahira-Sunose (KAS) and Flynn-Wall-Ozawa (FWO) models. Thermal decomposition of the cake showed thermograms indicating dehydration and devolitilization stages (200-400 °C)...
October 2016: Heliyon
Sumitra Datta, Gopalakrishnan Menon, Bincy Varughese
Proteolytic Aeromonas caviae P-1-1 growing at wide ranging pH (7.0-11.0) and moderate salinity (0-5% NaCl) was isolated from cattle-shed of Thanjavur, India. It produced lipase, gelatinase and polyhydroxybutyrate. Different culture conditions, incubation time, carbon and nitrogen sources, vitamins, amino acids, surfactants and metal ions for optimal growth and protease production of P-1-1 were examined. Maximum protease (0.128 U/mL) production was achieved with 1% fructose, 1% yeast extract, 0.1% ammonium sulfate, 3% NaCl, 0...
October 13, 2016: Preparative Biochemistry & Biotechnology
Analise Bartolo, Edmond Koyess, Josette Camilleri, Christopher Micallef
The main aim of root canal irrigation is to eliminate micro-organisms. Sodium hypochlorite (NaOCl) is considered to be the ideal material and raising its temperature potentiates the antimicrobial activity. NaOCl may lead to localised tissue necrosis when extruded past the root apex. This study analyses the use of high temperature root canal irrigation as an alternative process for the elimination of microorganisms from the root canal system. An experimental set-up was designed where a constant supply of heat was passed from a heat source through a copper wire inside the root canal...
September 2016: Healthcare Technology Letters
Awani Upadhyay, Aditya Pisupati, Timothy Jegla, Matt Crook, Keith J Mickolajczyk, Matthew Shorey, Laura E Rohan, Katherine A Billings, Melissa M Rolls, William O Hancock, Wendy Hanna-Rose
TRPV ion channels are directly activated by sensory stimuli and participate in thermo-, mechano- and chemo-sensation. They are also hypothesized to respond to endogenous agonists that would modulate sensory responses. Here, we show that the nicotinamide (NAM) form of vitamin B3 is an agonist of a Caenorhabditis elegans TRPV channel. Using heterologous expression in Xenopus oocytes, we demonstrate that NAM is a soluble agonist for a channel consisting of the well-studied OSM-9 TRPV subunit and relatively uncharacterized OCR-4 TRPV subunit as well as the orthologous Drosophila Nan-Iav TRPV channel, and we examine stoichiometry of subunit assembly...
October 12, 2016: Nature Communications
Tissiana Bortolotto, Francisco Betancourt, Ivo Krejci
This study evaluated the influence of curing devices on marginal adaptation of cavities restored with self-etching adhesive containing CQ and PPD initiators and hybrid composite. Twenty-four class V (3 groups, n=8) with margins located on enamel and dentin were restored with Clearfil S3 Bond and Clearfil APX PLT, light-cured with a monowave LED, multiwave LED and halogen light-curing unit (LCU). Marginal adaptation was evaluated with SEM before/after thermo-mechanical loading (TML). On enamel, significantly lower % continuous margins (74...
October 1, 2016: Dental Materials Journal
Gita Saini, Shalini Pant, Shri Om Singh, A A Kazmi, Tanveer Alam
Phthalates are endocrine-disrupting chemicals which affect endocrine system by bio-accumulation in aquatic organisms and produce adverse health effects in aquatic organisms as well as human beings, when come in contact. Present study focuses on occurrence and removal of two phthalates: diethylphthalate (DEP) and dibutylphthalate (DBP) in two full-scale wastewater treatment plants (WWTPs) i.e. sewage treatment plants (STPs) based on well-adopted technologies, activated sludge process (ASP) and sequencing batch reactor (SBR)...
November 2016: Environmental Monitoring and Assessment
Yasir Ali Arfat, Jasim Ahmed, Harsha Jacob
Agar-based active nanocomposite films were prepared by incorporating silver-copper (Ag-Cu) alloy nanoparticles (NPs) (0.5-4wt%) into glycerol plasticized agar solution. Thermo-mechanical, morphological, structural, and optical properties of the nanocomposite films were characterized by texture analyzer, differential scanning calorimetry (DSC), scanning electron microscope (SEM), X-ray diffraction (XRD), Fourier transforms infrared (FTIR) spectroscopy, and surface color measurement. Tensile strength and the melting temperature of the film increased linearly with NPs loading concentration...
January 2, 2017: Carbohydrate Polymers
Zhimin Sun, Changgu Shi, Xiangyang Wang, Qiang Fang, Jianying Huang
Sulfonated chitosan (SCS) was prepared via a facile chemical procedure by using 1,3-propane sultone attached to the backbone of chitosan. The resulting chitosan derivative was characterized by Fourier transform-infrared spectroscopy, nuclear magnetic resonance spectroscopy, gel permeation chromatography, elemental analysis, and thermo gravimetric analysis. The antibacterial experiments demonstrated that SCS exhibited higher antibacterial activities against Escherichia coli and Staphylococcus aureus with the minimum inhibitory concentration (MIC) of 0...
January 2, 2017: Carbohydrate Polymers
Daniel Saliba, Mazen Al-Ghoul
We report the synthesis of magnesium-aluminium layered double hydroxide (LDH) using a reaction-diffusion framework (RDF) that exploits the multiscale coupling of molecular diffusion with chemical reactions, nucleation and growth of crystals. In an RDF, the hydroxide anions are allowed to diffuse into an organic gel matrix containing the salt mixture needed for the precipitation of the LDH. The chemical structure and composition of the synthesized magnesium-aluminium LDHs are determined using powder X-ray diffraction (PXRD), thermo-gravimetric analysis, differential scanning calorimetry, solid-state nuclear magnetic resonance (SSNMR), Fourier transform infrared and energy dispersive X-ray spectroscopy...
November 13, 2016: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
Wang YaPing, Rao Ben, Yan Hong, Han Rui, Li Li, Liao Ping'an, Ma Lixin
l-glutamate oxidase (GLOD), encoded by the gox gene, catalyses the transformation of l-glutamic acid into α-ketoglutaric acid (α-KG). In the present study, Pichia pastoris was used for heterologous production of GLOD following optimization of the gox coding sequence for expression in the yeast host. A series of constructs based on the pHBM905BDM plasmid were engineered and transformed into P. pastoris to increase the gox copy number. The results indicated that GLOD protein levels and enzyme activity increased with increasing gox copy number...
January 2017: Protein Expression and Purification
Kamran Tahir, Sadia Nazir, Baoshan Li, Aftab Ahmad, Tabassum Nasir, Arif Ullah Khan, Sayyed Asim Ali Shah, Zia Ul Haq Khan, Ghulam Yasin, Muhammad Usman Hameed
There is a growing need to introduce eco-friendly and sustainable procedures for the synthesis of metal nanoparticles that include a mild reaction conditions, simple reaction setup, use of nontoxic medium such as water and plant extract, cost effectiveness as well as greater efficiency for biomedical and catalytic applications. For this purpose, small and highly dispersed palladium nanoparticles (PdNPs) were prepared by eco-friendly and cost effective green method using water soluble leaf extract of Sapium sebiferum as a reducing and capping agent...
September 23, 2016: Journal of Photochemistry and Photobiology. B, Biology
Shannon R Sweeney, Arthur Kavanaugh, Alessia Lodi, Bo Wang, David Boyle, Stefano Tiziani, Monica Guma
To determine whether characterisation of patients' metabolic profiles, utilising nuclear magnetic resonance (NMR) and mass spectrometry (MS), could predict response to rituximab therapy. 23 patients with active, seropositive rheumatoid arthritis (RA) on concomitant methotrexate were treated with rituximab. Patients were grouped into responders and non-responders according to the American College of Rheumatology improvement criteria, at a 20% level at 6 months. A Bruker Avance 700 MHz spectrometer and a Thermo Scientific Q Exactive Hybrid Quadrupole-Orbitrap mass spectrometer were used to acquire (1)H-NMR and ultra high pressure liquid chromatography (UPLC)-MS/MS spectra, respectively, of serum samples before and after rituximab therapy...
2016: RMD Open
Matthias Kröz, Marcus Reif, Danilo Pranga, Roland Zerm, Friedemann Schad, Erik Wim Baars, Matthias Girke
The concept of autonomic regulation (aR) reflects the relevance of the function of different autonomic systems for health. aR can be captured by questionnaires. We differentiate between a trait or constitutional aR questionnaire version including 12 (short-version) or 18 items, respectively, with three subscales (orthostatic-circulatory, rest/activity and digestive regulation), and an 18-item state aR questionnaire on the preceding week with four subscales (rest/activity, orthostatic-circulatory, thermo- and digestive regulation)...
September 2016: Journal of Integrative Medicine
Hongyu Yang, Qiang Zhu, Nandi Zhou, Yaping Tian
Prolyl aminopeptidases are specific exopeptidases that catalyze the hydrolysis of the N-terminus proline residue of peptides and proteins. In the present study, the prolyl aminopeptidase gene (pap) from Aspergillus oryzae JN-412 was optimized through the codon usage of Pichia pastoris. Both the native and optimized pap genes were inserted into the expression vector pPIC9 K and were successfully expressed in P. pastoris. Additionally, the activity of the intracellular enzyme expressed by the recombinant optimized pap gene reached 61...
November 2016: World Journal of Microbiology & Biotechnology
Khyati P Thakor, Miral V Lunagariya, Mohan N Patel
Palladium(II) complexes of type [Pd(L(n))Cl2] and [Pd(bdt)(L(n))] have been synthesized using 2-acetyl pyridine derivatives(L(n)) and benzene-1,2-dithiol(bdt). The synthesized complexes have been characterized by various analytical techniques like thermo gravimetric analysis(TGA), elemental analysis, conductance measurement and spectroscopic techniques like elemental analysis, mass spectra, absorption spectra, IR, (1)H NMR, Energy-dispersive X-ray spectroscopy(EDX). The interaction of the complexes with calf-thymus DNA (CT-DNA) has been explored by absorption titration, viscosity measurement methods...
September 14, 2016: Journal of Biomolecular Structure & Dynamics
Juilee A Kulkarni, Amelia M Avachat
Asenapine maleate (AM) is used in the treatment of schizophrenia. Its oral and sublingual bioavailability is <2% and 35%, respectively, due to first pass metabolism and poor solubility. To avoid first pass metabolism and to enhance solubility at all nasal pH conditions, thermo-responsive in situ nasal gel containing asenapine maleate-hydroxyl propyl β cyclodextrin inclusion complex (AM-HPβCD) was prepared in the present study. Inclusion complex (1:1 molar ratio) was characterized using UV spectroscopy, FITR and XRD techniques...
October 16, 2016: Drug Development and Industrial Pharmacy
Natividad Martinez, Agnes Psikuta, José Miguel Corberán, René M Rossi, Simon Annaheim
A novel thermo-physiological human head simulator for headgear testing was developed by coupling a thermal head manikin with a thermo-physiological model. As the heat flux at head-site is directly measured by the head manikin, this method provides a realistic quantification of the heat transfer phenomena occurring in the headgear, such as moisture absorption-desorption cycles, condensation, or moisture migration across clothing layers. Before coupling, the opportunities of the head manikin for representing the human physiology were evaluated separately...
September 9, 2016: International Journal of Biometeorology
Hakim Ma, Tang Xiao-Peng, Shi-Long Yang, Qiu-Min Lu, Ren Lai
It is hypothesized that protease inhibitors play an essential role in survival of venomous animals through protecting peptide/protein toxins from degradation by proteases in their prey or predators. However, the biological function of protease inhibitors in scorpion venoms remains unknown. In the present study, a trypsin inhibitor was purified and characterized from the venom of scorpion Mesobuthus eupeus, which enhanced the biological activities of crude venom components in mice when injected in combination with crude venom...
August 2016: Chinese Journal of Natural Medicines
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