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https://www.readbyqxmd.com/read/29150942/a-novel-epididymal-quiescence-factor-inhibits-sperm-motility-by-modulating-nos-activity-and-intracellular-no-cgmp-pathway
#1
Prasanta Ghosh, Sandipan Mukherjee, Arpita Bhoumik, Sandhya Rekha Dungdung
Mature and potentially motile spermatozoa stored in cauda epididymis in an inactive state for approximately 30 days; however during ejaculation they regain motility. To understand the actual molecular mechanism of the sperm quiescence during caudal stay, a proteinaceous quiescence factor (QF) has been purified from caprine epididymal plasma to apparent homogeneity. In the present study complete purification, detailed characterization as well as mechanistic pathway of QF has been described. QF was purified to 215 fold with 45% activity recovery...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29137785/synthesis-and-characterization-of-polyester-bionanocomposite-membrane-with-ultrasonic-irradiation-process-for-gas-permeation-and-antibacterial-activity
#2
Hashem Ahmadizadegan, Sheida Esmaielzadeh, Mahdi Ranjbar, Zahra Marzban, Fatemeh Ghavas
Optically active bionanocomposite membranes composed of polyester (PE) and cellulose/silica bionanocomposite (BNCs) prepared with simple, green and inexpensive ultrasonic irradiation process. It is a novel method to enhance the gas separation performance. The novel optically active diol containing functional trifluoromethyl groups was prepared in four steps reaction and it was fully characterized by different techniques. Commercially available silica nanoparticles were modified with biodegradable nanocellulose through ultrasonic irradiation technique...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137733/three-dimensional-organometallic-thallium-i-supramolecular-polymer-nanostructures-synthesized-with-sonochemical-process
#3
Maryam Moeinian, Kamran Akhbari, Jaursup Boonmak, Sujittra Youngme
A new three-dimensional thallium(I) supramolecular polymer, [Tl2(μ2-ATA)]n (1), [H2ATA=2-aminoterephthalic acid], has been synthesized and characterized. The single-crystal X-ray data of compound 1 shows one type of Tl(I) ion with a low coordination number. Compound 1 was self-assembled from Tl⋯C, Tl⋯O and Tl⋯N secondary interactions in thallium(I) coordination and the active lone pair on Tl(I) in this compound may be involved in donor bonding. Two sides of the aromatic ring of ATA(2-) anion have been involved in two types of secondary Tl⋯C approaches...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29115900/preparation-characterization-and-antitumor-activity-evaluation-of-apigenin-nanoparticles-by-the-liquid-antisolvent-precipitation-technique
#4
Weiwei Wu, Yuangang Zu, Li Wang, Lingling Wang, Huimei Wang, Yuanyuan Li, Mingfang Wu, Xiuhua Zhao, Yujie Fu
The present work aimed to apply the liquid antisolvent precipitation (LAP) method for preparing the apigenin nanoparticles and thereby improving the solubility and bioavailability of apigenin. The different experimental parameters on particle size were optimized through central composite design (CCD) using the Design-Expert(®) software. Under the optimum conditions, the particle size of the apigenin nanosuspension was about 159.2 nm. In order to get apigenin nanoparticles, the freeze-drying method was selected and the mannitol was used as a cryoprotectant...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29113889/production-optimization-purification-and-characterization-of-a-heat-tolerant-acidic-pectinase-from-bacillus-sp-zj1407
#5
Ping Yu, Chaochao Xu
Medium compositions for a heat-tolerant acidic pectinase production from Bacillus sp. ZJ1407 were optimized via response surface methodology (RSM) and its enzymatic properties were investigated. A 2-level factorial design was used to estimate the main effect of factors, and to screen the significant factors. A central composite design was used to find out the optimal concentrations of screened key factors. Lactose, tryptone and (NH4)2SO4 were found to have a significant influence on the pectinase activity (p <0...
November 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29111641/temperature-responsive-hierarchical-polymer-brushes-switching-from-bactericidal-to-cell-repellency
#6
Xianghong Wang, Shunjie Yan, Lingjie Song, Hengchong Shi, Huawei Yang, Shifang Luan, Yubin Huang, Jinghua Yin, Ather Farooq Khan, Jie Zhao
Unlike conventional poly(N-isopropylacrylamide) (PNIPAM)-based surfaces switching from bactericidal activity to bacterial repellency upon decreasing temperature, we developed a hierarchical polymer architecture, which could maintain bactericidal activities at room temperature while presenting bacterial repellency at physiological temperature. In this architecture, a thermoresponsive bactericidal upper layer consisting of PNIPAM-based copolymer and vancomycin (Van) moieties was built on an antifouling poly(sulfobetaine methacrylate) (PSBMA) bottom layer via sequential surface-initiated photoiniferter-mediated polymerization...
November 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29111075/humidity-activated-shape-memory-effect-on-plasticized-starch-based-biomaterials
#7
Valentina Sessini, Marina P Arrieta, Alberto Fernández-Torres, Laura Peponi
Humidity-activated shape memory behavior of plasticized starch-based films reinforced with the innovative combination of starch nanocrystals (SNCs) and catechin as antioxidant were studied. In a previous work, we reported the processing of gelatinized starch-based films filled with SNCs and catechin as antioxidant agent, and we observed that this novel combination leads to starch-based film with enhanced thermal and mechanical performance. In this work, the humidity-activated shape memory behavior of the previous developed starch-based films was characterized...
January 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29100029/validation-of-an-lc-ms-ms-assay-to-simultaneously-monitor-the-intracellular-active-metabolites-of-tenofovir-emtricitabine-and-lamivudine-in-dried-blood-spots
#8
Amanda P Schauer, Craig Sykes, Mackenzie L Cottrell, Heather Prince, Angela D M Kashuba
The ability to monitor adherence to antiretroviral therapy is critical for the interpretation of outcomes from clinical studies of HIV, and for optimizing patient care. The antiretrovirals tenofovir (TFV), emtricitabine (FTC), and lamivudine (3TC) are commonly included in drug regimens for HIV prevention and treatment. The active form of the drugs tenofovir diphosphate (TFVdp), emtricitabine triphosphate (FTCtp), and lamivudine triphosphate (3TCtp) are found intracellularly in erythrocytes and peripheral blood mononuclear cells (PBMCs)...
October 31, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29098882/ph-and-thermo-sensitive-mtx-loaded-magnetic-nanocomposites-synthesis-characterization-and-in-vitro-studies-on-a549-lung-cancer-cell-and-mr-imaging
#9
Masoud Farshbaf, Roya Salehi, Nasim Annabi, Rovshan Khalilov, Abolfazl Akbarzadeh, Soodabeh Davaran
In current study we proposed a facile method for fabrication of multifunctional pH- and thermo sensitive magnetic nanocamposites (MNCs) as a theranostic agent employing in targeted drug delivery and magnetic resonance imaging (MRI). To this end, we decorated Fe3O4 magnetic nanoparticles (MNPs) with N,N-dimethylaminoethyl methacrylate (DMAEMA) and N-isopropylacrylamide (NIPAAm), best known for their pH- and thermo sensitive properties, respectively. We also conjugated mesoporous silica nanoparticles (MSNs) to polymer matrix acting as drug container to enhance the drug encapsulation efficacy...
November 3, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29076512/enrichment-of-magnetic-particles-using-temperature-and-magnetic-field-gradients-induced-by-benchtop-fabricated-micro-electromagnets
#10
A Hosseini, D N Philpott, L Soleymani
The active transport of analytes inside biosensing systems is important for reducing the response time and enhancing the limit-of-detection of these systems. Due to the ease of functionalization with bio-recognition agents and manipulation with magnetic fields, magnetic particles are widely used for active and directed transport of biological analytes. On-chip active electromagnets are ideally suited for manipulating magnetic particles in an automated and miniaturized fashion inside biosensing systems. Unfortunately, the magnetic force exerted by these devices decays rapidly as we move away from the device edges, and increasing the generated force to the levels necessary for particle manipulation requires a parallel increase in the applied current and the resultant Joule heating...
November 21, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29075925/characterization-of-extracellular-proteases-of-acanthamoeba-genotype-t4-isolated-from-different-sources-in-iran
#11
Behroz Mahdavi Poor, Abdolhossein Dalimi, Fatemeh Ghafarifar, Fariba Khoshzaban, Jalal Abdolalizadeh
The members of the genus Acanthamoeba are ubiquitous, free-living amoebae found in various environments. The amoebae can cause severe complications in both, immunocompetent and immunocompromised individuals. The aim of this study was to characterize extracellular proteases of Acanthamoeba isolates from different sources belonging to genotype T4 as well as the determination of the pathogenicity potential to correlate pathogenicity with protease activity and protease banding pattern. A total of 19 isolates (11 clinical and 8 environmental) were cultured axenically, then the pathogenicity of the isolates was assessed by osmo- and thermo- tolerance tests...
December 2017: Parasitology Research
https://www.readbyqxmd.com/read/29071229/pantoprazole-sodium-loaded-microballoons-for-the-systemic-approach-in-vitro-and-in-vivo-evaluation
#12
Pravin Gupta, Manish Kumar, Darpan Kaushik
Purpose: Various floating and pulsatile drug delivery systems suffer from variations in the gastric transit time affecting the bioavailability of drugs. The objective of the study was to develop Pantoprazole Sodium (PAN) microballoons that may prolong the gastric residence time and could enhance the drug bioavailability. Methods: Microballoons were prepared using Eudragit(®)L100 by adopting emulsion solvent diffusion method with non-effervescent approach, in vitro studies were performed and the in vivo evaluation was carried out employing ethanol induced ulceration method...
September 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29070825/melanopsin-a-canonical-light-receptor-mediates-thermal-activation-of-clock-genes
#13
Maria Nathália Moraes, Leonardo Vinícius Monteiro de Assis, Keila Karoline Magalhães-Marques, Maristela Oliveira Poletini, Leonardo Henrique Ribeiro Graciani de Lima, Ana Maria de Lauro Castrucci
Melanopsin (OPN4) is a photo-pigment found in a small subset of intrinsically photosensitive ganglion cells (ipRGCs) of the mammalian retina. These cells play a role in synchronizing the central circadian pacemaker to the astronomical day by conveying information about ambient light to the hypothalamic suprachiasmatic nucleus, the site of the master clock. We evaluated the effect of a heat stimulus (39.5 °C) on clock gene (Per1 and Bmal1) expression in cultured murine Melan-a melanocytes synchronized by medium changes, and in B16-F10 melanoma cells, in the presence of the selective OPN4 antagonist AA92593, or after OPN4 knockdown by small interfering RNA (siRNA)...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29067700/polyphenol-oxidase-from-pectobacterium-atrosepticum-identification-and-cloning-of-gene-and-characteristics-of-the-enzyme
#14
Vladimir Gorshkov, Nadezhda Tarasova, Natalia Gogoleva, Elena Osipova, Olga Petrova, Evgeny Kovtunov, Yuri Gogolev
In the present study, we attempted to elucidate if the harmful phytopathogenic bacteria of Pectobacterium genus (P. atrosepticum) possess the enzymes for oxidation of phenolic compounds. Polyphenol oxidase (laccase) activity was revealed in P. atrosepticum cell lysates. Using bioinformatic analysis, an ORF encoding a putative copper-containing polyphenol oxidase of 241 amino acids with a predicted molecular mass of 25.9 kDa was found. This protein (named Pal1) shares significant level of identity with laccases of a new type described for several bacterial species...
October 25, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/29065836/stability-indicating-liquid-chromatographic-method-for-simultaneous-determination-of-aspirin-and-omeprazole
#15
Vandana B Patel, Aishwarya D Patel, Dimal A Shah
BACKGROUND: Aspirin combination is prescribed for the its thrombolytic activity where gastric ulceration is the major side effects of aspirin which can be prevented by combining it with proton pump inhibitor omeprazole. Present study describes development of analytical method for the estimation of aspirin and omeprazole in combination. Objective of the present study was to develop and validate chromatographic method for simultaneous analysis of aspirin and omeprazole. METHODS: Isocratic, reversed phase stability indicating liquid chromatographic method was developed for the simultaneous determination of Aspirin and Omeprazole in combination...
October 23, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29050592/eco-friendly-films-prepared-from-plantain-flour-pcl-blends-under-reactive-extrusion-conditions-using-zirconium-octanoate-as-a-catalyst
#16
Tomy J Gutiérrez, Vera A Alvarez
Plantain flour (Musa ssp., group AAB, sub-group clone Harton)/poly(ε-caprolactone) (PCL) blends, containing glycerol as a plasticizer, were prepared by reactive extrusion (REx) in a twin-screw extruder using zirconium octanoate (Zr(Oct)4) as a catalyst, followed by thermo-compression molding for film development. The films were then characterized in terms of their: infrared (FTIR) spectra, water solubility, thermogravimetric (TGA) curves, differential scanning calorimetry (DSC) thermograms, and X-ray diffraction (XDR) diffractograms, as well as their microstructural, mechanical and antimicrobial properties in order to (1) compare the effects of PCLs with two different molecular weights (Mw) on the characteristics of the plantain flour/PCL blends, and (2) determine whether using Zr(Oct)4 in the production of active composite polymer materials improves their properties...
December 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29046838/enhancement-of-mechanical-and-electrical-properties-of-continuous-fiber-reinforced-epoxy-composites-with-stacked-graphene
#17
Naum Naveh, Olga Shepelev, Samuel Kenig
Impregnation of expandable graphite (EG) after thermal treatment with an epoxy resin containing surface-active agents (SAAs) enhanced the intercalation of epoxy monomer between EG layers and led to further exfoliation of the graphite, resulting in stacks of few graphene layers, so-called "stacked" graphene (SG). This process enabled electrical conductivity of cured epoxy/SG composites at lower percolation thresholds, and improved thermo-mechanical properties were measured with either Kevlar, carbon or glass-fiber-reinforced composites...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29045065/direct-coupling-of-thermo-and-photocatalysis-for-conversion-of-co2-h2-o-into-fuels
#18
Li Zhang, Guoguo Kong, Yaping Meng, Jinshu Tian, Lijie Zhang, Shaolong Wan, Jingdong Lin, Yong Wang
Photocatalytic CO2 reduction into renewable hydrocarbon solar fuels is considered as a promising strategy to simultaneously address global energy and environmental issues. This study focused on the direct coupling of photocatalytic water splitting and thermocatalytic hydrogenation of CO2 in the conversion of CO2 -H2 O into fuels. Specifically, it was found that direct coupling of thermo- and photocatalysis over Au-Ru/TiO2 leads to activity 15 times higher (T=358 K; ca. 99 % CH4 selectivity) in the conversion of CO2 -H2 O into fuels than that of photocatalytic water splitting...
October 18, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29035507/sequential-delivery-of-doxorubicin-and-zoledronic-acid-to-breast-cancer-cells-by-cb-7-modified-iron-oxide-nanoparticles
#19
Farah Benyettou, Marwa Alhashimi, Matthew O'Connor, Renu Pasricha, Jeremy Brandel, Hassan Traboulsi, Javed Mazher, John-Carl Olsen, Ali Trabolsi
Drug-loaded magnetic nanoparticles were synthesized and used for the sequential delivery of the antiresorptive agent zoledronic acid (Zol) and the cytotoxic drug doxorubicin (Dox) to breast cancer cells (MCF-7). Zol was attached to bare iron oxide nanoparticles (IONPs) via phosphonate coordination to form Z-NPs. The unbound imidazole of Zol was then used to complex the organic macrocycle CB[7] to obtain CZ-NPs. Dox was complexed to the CZ-NPs to form the fully loaded particles (DCZ-NPs), which were stable in solution at 37 °C and physiological pH (7...
November 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29035313/microstructural-modification-and-characterization-of-sericite
#20
Yu Liang, Hao Ding, Sijia Sun, Ying Chen
Activated sericite was prepared by thermal modification, acid activation and sodium modification, and it was characterized by X-ray diffraction (XRD) analysis, differential scanning calorimetry (DSC), N₂ adsorption test, thermo-gravimetric analysis (TGA), nuclear magnetic resonance (NMR), and scanning electron microscope (SEM). The results indicated that the crystallinity of raw sericite decreased after thermal modification; the pores with sizes between 5 nm to 10 nm of thermal-modified sericite have collapsed and the surface area increased after thermal modification...
October 16, 2017: Materials
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