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https://www.readbyqxmd.com/read/29334460/multiple-stimuli-responses-of-stereo-isomers-of-aie-active-ethynylene-bridged-and-pyridyl-modified-tetraphenylethene
#1
Zhaoyang Wang, Xiao Cheng, Anjun Qin, Haoke Zhang, Jing Zhi Sun, Ben Zhong Tang
Luminescent molecules with aggregation-induced emission (AIE) property, or AIE-gens are typical stimuli-responsive materials and many AIE-gens have shown luminescent responses to mechano-, thermo-, electro-, vapo- and/or solvato-stimulus, but the detailed structure-property relationship has been addressed for only few of them. Here, we report a tetraphenylethene (TPE) derivative with pyridyl modifiers and ethynylene bridges. The (Z)- and (E)-isomers are clearly purified and both of them are AIE-active and demonstrate multiple luminescent responses to external stimuli...
January 15, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29334116/interface-engineering-of-a-ceo2-cu3p-nanoarray-for-efficient-alkaline-hydrogen-evolution
#2
Zao Wang, Huitong Du, Zhiang Liu, Hui Wang, Abdullah M Asiri, Xuping Sun
It is of great importance to design and develop highly active electrocatalysts for the hydrogen evolution reaction (HER) under alkaline conditions. In this work, we report the development of a CeO2-Cu3P nanoarray supported on nickel foam (CeO2-Cu3P/NF) as an excellent HER catalyst with the demand of an overpotential of only 148 mV to deliver a geometrical catalytic current density of 20 mA cm-2 in 1.0 M KOH. Remarkably, this catalyst also shows strong long-term electrochemical durability for at least 100 h with nearly 100% Faradaic efficiency...
January 15, 2018: Nanoscale
https://www.readbyqxmd.com/read/29327704/emerging-nonmetabolic-functions-of-skin-fat
#3
REVIEW
Christian F Guerrero-Juarez, Maksim V Plikus
Although the major white adipose depots evolved primarily to store energy, secrete hormones and thermo-insulate the body, multiple secondary depots developed additional specialized and unconventional functions. Unlike any other fat tissue, dermal white adipose tissue (dWAT) evolved a large repertoire of novel features that are central to skin physiology, which we discuss in this Review. dWAT exists in close proximity to hair follicles, the principal appendages of the skin that periodically grow new hairs. Responding to multiple hair-derived signals, dWAT becomes closely connected to cycling hair follicles and periodically cycles itself...
January 12, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29320631/thermoresponsive-co-biodegradable-linear-dendritic-nanoparticles-for-sustained-release-of-nerve-growth-factor-to-promote-neurite-outgrowth
#4
Young Shin Kim, Muhammad Gulfam, Tao L Lowe
Thermo-responsive and biodegradable linear-dendritic nanoparticles containing poly(N-isopropylacrylamide), poly(L-lactic acid) and poly(L-lysine) dendron were investigated for sustained release of nerve growth factor (NGF) in response to temperature change. The nanoparticles and their degradants were not cytotoxic to neuron-like PC12 cells for at least one month. The nanoparticles were preferentially taken up by PC12 cells 6 to 13 times more at temperature above (37 °C) than below (25 °C) the lower critical solution temperature of the nanoparticles...
January 10, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29318252/spatial-requirement-for-pamo-for-transformation-of-non-native-linear-substrates
#5
Alexandra T P Carvalho, Daniel F A R Dourado, Timofey Skvortsov, Miguel de Abreu, Lyndsey J Ferguson, Derek J Quinn, Thomas S Moody, Meilan Huang
Phenylacetone monooxygenase is the most stable and thermo-tolerant member of the Baeyer-Villiger monooxygenases family, and therefore it is an ideal candidate for the synthesis of industrially relevant ester or lactone compounds. However, its limited substrate scope has largely limited its industrial applications. Linear substrates are interesting from an industrial point of view, it is thus necessary to identify the essential spatial requirement for achieving high conversions for non-native linear substrates...
January 10, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29316408/agonists-and-antagonists-of-protease-activated-receptor-2-discovered-within-a-dna-encoded-chemical-library-using-mutational-stabilization-of-the-target
#6
Dean G Brown, Giles A Brown, Paolo Centrella, Kaan Certel, Robert M Cooke, John W Cuozzo, Niek Dekker, Christoph E Dumelin, Andrew Ferguson, Cédric Fiez-Vandal, Stefan Geschwindner, Marie-Aude Guié, Sevan Habeshian, Anthony D Keefe, Oliver Schlenker, Eric A Sigel, Arjan Snijder, Holly T Soutter, Linda Sundström, Dawn M Troast, Giselle Wiggins, Jing Zhang, Ying Zhang, Matthew A Clark
The discovery of ligands via affinity-mediated selection of DNA-encoded chemical libraries is driven by the quality and concentration of the protein target. G-protein-coupled receptors (GPCRs) and other membrane-bound targets can be difficult to isolate in their functional state and at high concentrations, and therefore have been challenging for affinity-mediated selection. Here, we report a successful selection campaign against protease-activated receptor 2 (PAR2). Using a thermo-stabilized mutant of PAR2, we conducted affinity selection using our >100-billion-compound DNA-encoded library...
January 1, 2018: SLAS Discovery
https://www.readbyqxmd.com/read/29304195/thermal-discrimination-and-transgenerational-temperature-response-in-bemisia-tabaci-mediterranean-hemiptera-aleyrodidae-putative-involvement-of-the-thermo-sensitive-receptor-bttrpa
#7
Tian-Mei Dai, Yu-Sheng Wang, Wan-Xue Liu, Zhi-Chuang Lü, Fang-Hao Wan
Anthropogenic climate change and global warming are expected to alter the geographic distribution and abundance of many ectothermic species, which will increase the invasion of new areas by exotic species. To survive in variable or fluctuating temperature conditions, insects require sensitive thermal sensory mechanisms to detect external thermal stimuli and induce the appropriate behavioral and physiological responses. TRPA, a thermal-activated transient receptor potential (TRP) family ion channel, is essential for thermotaxis in insects...
January 3, 2018: Environmental Entomology
https://www.readbyqxmd.com/read/29303523/two-novel-dawson-like-tungstoantimonates-with-difunctional-photocatalytic-and-magnetic-properties
#8
Lin Shi, Xiao-Mei Gao, Ting-Yu Liu, Xiao-Hui Huang, Zhi-Hui Gong, Yi-Ping Chen, Yan-Qiong Sun
Two novel inorganic-organic hybrids containing the pyramidal SbO3 group in Dawson-like POMs based on an organic ligand with different coordination modes, namely {Ni(phen)3}3[SbW18O60]·(H3O)3·7H2O (1) and [CuI(phen)(H2O)3]{[Cu(phen)2(H2O)2]2[SbW18O60]}·2H2O (2) (phen = 1,10-phenanthroline), have been synthesized. The catalytic property of compound 1 was studied as the first case for an {M18} cluster containing the pyramidal SbO3 group. Remarkably, compound 1 has excellent photocatalytic activity for RhB degradation and the probable mechanism of degradation was discussed...
January 5, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29301086/role-of-hydrogen-in-high-yield-growth-of-boron-nitride-nanotubes-at-atmospheric-pressure-by-induction-thermal-plasma
#9
Keun Su Kim, Martin Couillard, Homin Shin, Mark Plunkett, Dean Ruth, Christopher T Kingston, Benoit Simard
Recently, we demonstrated scalable manufacturing of boron nitride nanotubes (BNNTs) directly from hBN powder by using induction thermal plasma, with a high-yield rate approaching to 20 g/h. The main finding was that the presence of hydrogen is crucial for the high-yield growth of BNNTs. Here we investigate the detailed role of hydrogen by numerical modeling and in-situ optical emission spectroscopy (OES), and reveal that both the thermo-fluidic fields and chemical pathways are significantly altered by hydrogen in favor of rapid growth of BNNTs...
January 4, 2018: ACS Nano
https://www.readbyqxmd.com/read/29296275/consortium-inoculum-of-five-thermo-tolerant-phosphate-solubilizing-actinomycetes-for-multipurpose-biofertilizer-preparation
#10
Arusha P Nandimath, Dilip D Karad, Shantikumar G Gupta, Arun S Kharat
Background and Objectives: Alkaline pH of the soil facilitates the conversion of phosphate present in phosphate fertilizer applied in the field to insoluble phosphate which is not available to plants. Problem of soluble phosphate deficiency arises, primarily due to needless use of phosphate fertilizer. We sought to biofertilizer with the thermo-tolerant phosphate solubilizing actinomycetes consortium that could convert insoluble phosphate to soluble phosphate at wider temperature range...
October 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29290820/breaking-the-barrier-potent-anti-inflammatory-activity-following-efficient-topical-delivery-of-etanercept-using-thermoresponsive-nanogels
#11
M Giulbudagian, G Yealland, S Hönzke, A Edlich, B Geisendörfer, B Kleuser, S Hedtrich, M Calderón
Topical administration permits targeted, sustained delivery of therapeutics to human skin. Delivery to the skin, however, is typically limited to lipophilic molecules with molecular weight of < 500 Da, capable of crossing the stratum corneum. Nevertheless, there are indications protein delivery may be possible in barrier deficient skin, a condition found in several inflammatory skin diseases such as psoriasis, using novel nanocarrier systems. METHODS: Water in water thermo-nanoprecipitation; dynamic light scattering; zeta potential measurement; nanoparticle tracking analysis; atomic force microscopy; cryogenic transmission electron microscopy; UV absorption; centrifugal separation membranes; bicinchoninic acid assay; circular dichroism; TNFα binding ELISA; inflammatory skin equivalent construction; human skin biopsies; immunohistochemistry; fluorescence microscopy; western blot; monocyte derived Langerhans cells; ELISA Results: Here, we report the novel synthesis of thermoresponsive nanogels (tNG) and the stable encapsulation of the anti-TNFα fusion protein etanercept (ETR) (~150 kDa) without alteration to its structure, as well as temperature triggered release from the tNGs...
2018: Theranostics
https://www.readbyqxmd.com/read/29289886/synthesis-of-3s-4s-5s-trihydroxylpiperidine-derivatives-as-enzyme-stabilizers-to-improve-therapeutic-enzyme-activity-in-fabry-patient-cell-lines
#12
Huang-Yi Li, Jay-Der Lee, Chiao-Wen Chen, Ying-Chieh Sun, Wei-Chieh Cheng
A series of 3S,4S,5S-trihydroxylated piperidines bearing structural diversity at C-2 or C-6 positions has been synthesized and tested to determine their ability to stabilize the activity of recombinant human α-Galactosidase A (rh-α-Gal A). Hit molecules were identified by rapid inhibitory activity screening, and then further investigated for their ability to protect this enzyme from thermo-induced denaturation and enhance its activity in Fabry patient cell lines. Our study resulted in the identification of a new class of small molecules as enzyme stabilizers for the potential treatment of Fabry disease...
December 12, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29274484/effect-of-water-activity-and-heating-rate-on-staphylococcus-aureus-heat-resistance-in-walnut-shells
#13
Lihui Zhang, Xiaoxi Kou, Shuang Zhang, Teng Cheng, Shaojin Wang
Water activity (aw) and heating rate have shown important effects on the thermo-tolerance of pathogens in low moisture foods during thermal treatments. In this study, three strains were selected to compare the heat resistance in walnut shell powder and finally the most heat resistant S. aureus ATCC 25923 was chosen to investigate the influence of aw and heating rate using a heating block system (HBS). The results showed that S. aureus ATCC 25923 became more thermo-tolerant at lower aw. The D-values of S. aureus ATCC 25923 increased with decreasing water activity and heating rates (<1°C/min)...
December 18, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29259585/thermal-stability-and-reconstitution-ability-of-listeria-phages-p100-and-a511
#14
Hanie Ahmadi, Devon Radford, Andrew M Kropinski, Loong-Tak Lim, Sampathkumar Balamurugan
The study evaluated the thermal-stability of Listeria phages P100 and A511 at temperatures simulating the preparation of ready-to-eat meats. The phage infectivity after heating to 71°C and holding for a minimum of 30 s, before eventually cooling to 4°C were examined. Higher temperatures of 75, 80, and 85°C were also tested to evaluate their effect on phages thermal-stability. This study found that despite minor differences in the amino acid sequences of their structural proteins, the two phages responded differently to high temperatures...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29243754/recycling-of-zincite-zno-via-uptake-of-hydrogen-halides
#15
Oday H Ahmed, Mohammednoor Altarawneh, Mohammad Al-Harahsheh, Zhong-Tao Jiang, Bogdan Z Dlugogorski
Hydrogen halides (HCl/HBr) represent major halogen fragments from the thermal decomposition of halogen laden materials, most notably PVC and brominated flame retardants (BFRs). Co-pyrolysis of halogen-containing solid waste with metal oxides is currently deployed as a mainstream strategy to treat halogen content as well as to recycle the valuable metallic fraction embedded in electric arc furnace dust (EAFD) and e-waste. However, designing an industrial-scale recycling facility necessitates accurate knowledge on mechanistic and thermo-kinetic parameters dictating the interaction between metal oxides and hydrogen halides...
December 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29240906/differential-inhibition-of-helicoverpa-armigera-lep-noctuidae-gut-digestive-trypsin-by-extracted-and-purified-inhibitor-of-datura-metel-solanales-solanaceae
#16
Reza Navaei-Bonab, Majid Kazzazi, Moosa Saber, Mohammad Vatanparast
The cotton bollworm, Helicoverpa armigera Hubner (Lep: Noctuidae), is an economically important pest of numerous major food crops worldwide. Protease inhibitors from plants, expressed constitutively in transgenic crops, have potential for pest management as an alternative to chemical pesticides. In this study, a protease inhibitor was isolated, purified, and characterized from Datura metel L. seeds. The purity of the isolated inhibitor was confirmed by reverse-phase high-performance liquid chromatography, and activity staining showed one major peak and one clear activity band for the protein...
December 12, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29240420/iodine-promoted-aromatization-of-p-menthane-type-phytocannabinoids
#17
Federica Pollastro, Diego Caprioglio, Patrizia Marotta, Aniello Schiano Moriello, Luciano De Petrocellis, Orazio Taglialatela-Scafati, Giovanni Appendino
Treatment with iodine cleanly converts various p-menthane-type phytocannabinoids and their carboxylated precursors into cannabinol (CBN, 1a). The reaction is superior to previously reported protocols in terms of simplicity and substrate range, which includes not only tricyclic tetrahydrocannabinols such as Δ9-THC (2a) but also bicyclic phytocannabinoids such as cannabidiol (CBD, 3a). Lower homologues from the viridin series (2c and 3c, respectively) afforded cannabivarin (CBV), a non-narcotic compound that, when investigated against a series of ionotropic (thermo-TRPs) biological end-points of phytocannabinoids, retained the submicromolar TRPA1-activating and TRPM8-inhibiting properties of CBN, while also potently activating TRPV2...
December 14, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29222942/microbial-communities-in-natural-rubber-coagula-during-maturation-impacts-on-technological-properties-of-dry-natural-rubber
#18
Mélanie Salomez, Maeva Subileau, Tatiana Vallaeys, Sylvain Santoni, Fréderic Bonfils, Jérôme Sainte-Beuve, Jutharat Intapun, Françoise Granet, Laurent Vaysse, Éric Dubreucq
AIM: To characterize microbial communities present in natural rubber coagula from Hevea brasiliensis latex during maturation and identify microbial taxa (bacteria and fungi) having an impact on dry natural rubber properties. METHODS AND RESULTS: Microbial community dynamics in natural rubber coagula maturated under controlled conditions were compared and related with the evolution of dry natural rubber properties. The pyrosequencing of 16S (119,837 effective reads) and 18S (131,879 effective reads) rRNA gene regions was performed on 21 samples covering different maturation times and two aeration conditions...
December 9, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29220364/an-attempt-to-interpret-a-biochemical-mechanism-of-c4-photosynthetic-thermo-tolerance-under-sudden-heat-shock-on-detached-leaf-in-elevated-co2-grown-maize
#19
Mingnan Qu, James A Bunce, Richard C Sicher, Xiaocen Zhu, Bo Gao, Genyun Chen
Detached leaves at top canopy structures always experience higher solar irradiance and leaf temperature under natural conditions. The ability of tolerance to high temperature represents thermotolerance potential of whole-plants, but was less of concern. In this study, we used a heat-tolerant (B76) and a heat-susceptible (B106) maize inbred line to assess the possible mitigation of sudden heat shock (SHS) effects on photosynthesis (PN) and C4 assimilation pathway by elevated [CO2]. Two maize lines were grown in field-based open top chambers (OTCs) at ambient and elevated (+180 ppm) [CO2]...
2017: PloS One
https://www.readbyqxmd.com/read/29212419/surface-modification-of-phbv-nanofiber-mats-for-rapid-cell-cultivation-and-harvesting
#20
Young-Gwang Ko, Young-Jin Kim, Won Ho Park, Donghwan Cho, Ho Yun Chung, Oh Hyeong Kwon
To maintain the original function of a specific tissue for therapeutic tissue engineering, an advanced cell culture surface for repeat cell proliferation is necessary. We designed a novel cell proliferation and rapid harvesting surface by combining nonwoven nanofiber mat and a thermo-responsive polymer. Nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) mats were fabricated by the electrospinning technique. A poly(N-isopropylacrylamide) (PNIPAM) thermo-responsive layer was grafted on the PHBV nanofiber mat by electron beam irradiation...
December 7, 2017: Journal of Biomaterials Science. Polymer Edition
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