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https://www.readbyqxmd.com/read/27926579/the-influence-of-coronary-plaque-morphology-assessed-by-optical-coherence-tomography-on-final-microvascular-function-after-stenting-in-patients-with-st-elevation-myocardial-infarction
#1
Giovanni L De Maria, Niket Patel, Mathias Wolfrum, Gregor Fahrni, George Kassimis, Italo Porto, Sam Dawkins, Robin P Choudhury, John C Forfar, Bernard D Prendergast, Keith M Channon, Rajesh K Kharbanda, Hector M Garcia-Garcia, Adrian P Banning
OBJECTIVES: The index of microcirculatory resistance (IMR) provides a reproducible assessment of the status of coronary microvasculature in patients with ST-elevation myocardial infarction (STEMI). Frequency-domain optical coherence tomography (FD-OCT) enables detailed assessment of the morphology of coronary plaque.We sought to determine the influence of the initial culprit coronary plaque anatomy within the infarct-related artery on IMR after stenting in STEMI. PATIENTS AND METHODS: In 25 STEMI patients IMR was measured immediately before and after stent implantation...
December 6, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/27924867/constraints-and-spandrels-of-interareal-connectomes
#2
Mikail Rubinov
Interareal connectomes are whole-brain wiring diagrams of white-matter pathways. Recent studies have identified modules, hubs, module hierarchies and rich clubs as structural hallmarks of these wiring diagrams. An influential current theory postulates that connectome modules are adequately explained by evolutionary pressures for wiring economy, but that the other hallmarks are not explained by such pressures and are therefore less trivial. Here, we use constraint network models to test these postulates in current gold-standard vertebrate and invertebrate interareal-connectome reconstructions...
December 7, 2016: Nature Communications
https://www.readbyqxmd.com/read/27924583/dissecting-cell-fate-determination-through-integrated-mathematical-modeling-of-the-erk-mapk-signaling-pathway
#3
Sung-Young Shin, Lan K Nguyen
The past three decades have witnessed an enormous progress in the elucidation of the ERK/MAPK signaling pathway and its involvement in various cellular processes. Because of its importance and complex wiring, the ERK pathway has been an intensive subject for mathematical modeling, which facilitates the unraveling of key dynamic properties and behaviors of the pathway. Recently, however, it became evident that the pathway does not act in isolation but closely interacts with many other pathways to coordinate various cellular outcomes under different pathophysiological contexts...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27924336/the-single-molecule-electrical-conductance-of-a-rotaxane-hexayne-supramolecular-assembly
#4
David C Milan, Maximilian Krempe, Ali K Ismael, Levon D Movsisyan, Michael Franz, Iain Grace, Richard J Brooke, Walther Schwarzacher, Simon J Higgins, Harry L Anderson, Colin J Lambert, Rik R Tykwinski, Richard J Nichols
Oligoynes are archetypical molecular wires due to their 1-D chain of conjugated carbon atoms and ability to transmit charge over long distances by coherent tunneling. However, the stability of the oligoyne can be an issue. Here we address this problem by two stabilization methods, namely sterically shielding endgroups, and rotaxination to produce an insulated molecular wire. We demonstrate the threading of a hexayne within a macrocycle to form a rotaxane and report measurements of the electrical conductance of this single supramolecular assembly within an STM break junction...
December 7, 2016: Nanoscale
https://www.readbyqxmd.com/read/27924097/editorial-guidewire-trauma-a-key-component-of-post-ercp-pancreatitis-that-is-best-controlled-by-the-endoscopist
#5
Indu Srinivasan, Martin L Freeman
Recent studies have revealed that deep pancreatic duct wire passage, even in the absence of contrast injection, is a major technique-related culprit in post-ERCP pancreatitis, unless followed by placement of a pancreatic stent. As guidewire cannulation becomes increasingly widespread, precise control of the guidewire is thus critical. The first randomized trial to compare endoscopist-controlled wire guided vs. assistant-controlled bile duct cannulation has shown a significant reduction in post ERCP pancreatitis when the physician manipulates the wire...
December 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27923485/randomized-multicenter-trial-comparing-sternotomy-closure-with-rigid-plate-fixation-to-wire-cerclage
#6
Keith B Allen, Vinod H Thourani, Yoshifumi Naka, Kendra J Grubb, John Grehan, Nirav Patel, T Sloane Guy, Kevin Landolfo, Marc Gerdisch, Mark Bonnell, David J Cohen
OBJECTIVE: To evaluate sternal healing, complications, and costs after sternotomy closure with rigid plate fixation or wire cerclage. METHODS: This prospective, single-blinded, multicenter trial randomized 236 patients at 12 US centers at the time of sternal closure to either rigid plate fixation (n = 116) or wire cerclage (n = 120). The primary endpoint, sternal healing at 6 months, was evaluated by a core laboratory using computed tomography and a 6-point scale (greater scores represent greater healing)...
November 17, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27923460/comparison-of-characteristics-and-complications-in-men-versus-women-undergoing-chronic-total-occlusion-percutaneous-intervention
#7
Vinoda Sharma, William Wilson, William Smith, Margaret McEntegart, Keith Oldroyd, Novalia Sidik, Alan Bagnall, Mohaned Egred, John Irving, Julian Strange, Thomas Johnson, Simon Walsh, Colm Hanratty, James Spratt
Gender differences exist in clinical outcomes after routine percutaneous coronary intervention (PCI), but studies reporting such outcomes after chronic total occlusion (CTO) PCI are limited. We assessed the characteristics and outcomes of female patients undergoing CTO PCI. We retrospectively analyzed a dedicated national (United Kingdom) prospective CTO database from 2011 to 2015 for outcomes and characteristics of female patients undergoing CTO PCI (unmatched and propensity matched). Female patients constituted 20...
November 16, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27923353/the-feasibility-and-safety-of-a-through-and-through-wire-technique-for-central-venous-occlusion-in-dialysis-patients
#8
Yonghui Huang, Bing Chen, Guosheng Tan, Gang Cheng, Yi Zhang, Jiaping Li, Jianyong Yang
BACKGROUND: To retrospectively compare the operation time, success rate and efficacy between unidirectional and bidirectional procedures in the treatment of central venous occlusion diseases (CVOD), assess the advantages of the bidirectional approach, and determine the characteristics of CVOD appropriate for the bidirectional approach treatment. METHODS: A total of 49 patients who underwent endovascular interventions with all relevant data between January 2011 and December 2015 at the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, were included in this retrospective study, and were categorized into two groups: the 19 patients in group 1 had undergone percutaneous transluminal venoplasty (PTV) via a conventional technique (unidirectional procedure from the vein distal or proximal to the obstructive lesion), and the 30 in group 2 had undergone flossing wire technique (bidirectional procedure from femoral vein and the vein distal to obstructive lesion and using a flossing wire technique)...
December 7, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27922952/effect-of-energy-drink-on-bone-formation-in-the-expanded-inter-premaxillary-suture
#9
Muhammet Birlik, Hakki Oguz Kazancioglu, Mehmet Şerif Aydin, Sertac Aksakalli, Seref Ezirganli
Maxillary expansion of the median palatal suture is a common procedure in orthodontics. Even after retention, there is a strong tendency to relapse in the expanded suture. The authors' objectives are to accelerate the bone formation process in the expanded suture and to reduce the required retention time by using an energy drink (ED). Twenty rats were divided into 2 groups (n = 20). The expansion-only group was defined as the control group (Group C). The other group was defined as the expansion-plus-energy drink group (Group ED)...
December 5, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27921015/pediatric-olecranon-fractures-associated-with-radial-neck-fractures-review-and-report-of-two-cases
#10
Kemal Gokkus, Ozkan Kose, Murat Saylik, Ergin Sagtas, Ahmet Turan Aydin
INTRODUCTION: The debate regarding the description on classification and nomenclature of the injury which includes olecranon fracture associated with radial neck fractures in children is ongoing. We report two pediatric cases that could not be classified in a Monteggia-equivalents system and were treated with open reduction and k-wire fixation. The aim of this study was to perform a systematic review regarding pediatric radial neck fractures associated with olecranon fractures and presentation of two pediatric cases of olecranon fractures associated with radial neck fractures with radiocapitellar dislocation...
July 2016: Trauma Monthly
https://www.readbyqxmd.com/read/27920421/a-missing-guide-wire-after-placement-of-peripherally-inserted-central-venous-catheter
#11
Muhammad Kashif, Hafiz Hashmi, Preeti Jadhav, Misbahuddin Khaja
BACKGROUND Central venous catheterization is a common tool used in critically ill patients to monitor central venous pressure and administer fluids and medications such as vasopressors. Here we present a case of a missing guide wire after placement of peripherally inserted central catheter (PICC), which was incidentally picked up by bedside ultrasound in the intensive care unit.  CASE REPORT A 50-year-old Hispanic male was admitted to the intensive care unit for alcohol intoxication. He was managed for septic shock and required placement of a peripherally inserted central line in his left upper extremity for antibiotics and vasopressor administration...
December 6, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27919637/critical-hand-ischemia-treatment-via-orbital-atherectomy-a-single-center-observational-retrospective-analysis
#12
Abdul Bahro, Zsuzsanna Igyarto, Brad Martinsen
BACKGROUND/PURPOSE: Critical hand ischemia (CHI) can be devastating and may result in amputation. Distal vessel calcification has been shown to be a major factor in causing CHI. Atherectomy in the upper extremities is not typically considered due to the small anatomy; however, the Diamondback 360° Peripheral Orbital Atherectomy System (OAS) (Cardiovascular Systems, Inc.) can access treatment areas with a reference vessel diameter of 1.5mm. METHODS/MATERIALS: A retrospective, observational, single center (Merit Health Center, Jackson, MS) analysis of 11 CHI patients with calcific disease of the radial artery treated with orbital atherectomy (OAS) was completed...
October 29, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/27918583/the-gene-regulatory-network-of-lens-induction-is-wired-through-meis-dependent-shadow-enhancers-of-pax6
#13
Barbora Antosova, Jana Smolikova, Lucie Klimova, Jitka Lachova, Michaela Bendova, Iryna Kozmikova, Ondrej Machon, Zbynek Kozmik
Lens induction is a classical developmental model allowing investigation of cell specification, spatiotemporal control of gene expression, as well as how transcription factors are integrated into highly complex gene regulatory networks (GRNs). Pax6 represents a key node in the gene regulatory network governing mammalian lens induction. Meis1 and Meis2 homeoproteins are considered as essential upstream regulators of Pax6 during lens morphogenesis based on their interaction with the ectoderm enhancer (EE) located upstream of Pax6 transcription start site...
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27918097/sugars-and-fat-a-healthy-way-to-generate-functional-regulatory-t-cells
#14
Sarah Sharon Gabriel, Axel Kallies
Cellular metabolism has emerged as an important regulator of adaptive immunity. While the metabolic requirements of conventional T cells are increasingly understood, the role of cellular metabolism in Foxp3(+) regulatory T (Treg) cells is less clear. Although it is well accepted that repression of Akt/mTOR, HIF-1α and aerobic glycolysis are important for the efficient generation of Treg cells in vitro, clear evidence how these pathways impact on Treg-cell development in vivo is limited. Furthermore, newer studies have shown that the same pathways that appear to suppress Treg-cell development are active in and required for functionally mature Treg cells...
December 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27918024/uniform-and-perfectly-linear-current-voltage-characteristics-of-nitrogen-doped-armchair-graphene-nanoribbons-for-nanowires
#15
Lingling Liu, Xiao-Fei Li, Qing Yan, Qin-Kun Li, Xiang-Hua Zhang, Mingsen Deng, Qi Qiu, Yi Luo
Metallic nanowires with desired properties for molecular integrated circuits (MICs) are especially significant in molectronics, but preparing such wires at a molecular level still remains challenging. Here, we propose, from first principles calculations, experimentally realizable edge-nitrogen-doped graphene nanoribbons (N-GNRs) as promising candidates for nanowires. Our results show that edge N-doping has distinct effects on the electronic structures and transport properties of the armchair GNRs and zigzag GNRs (AGNRs, ZGNRs), due to the formation of pyridazine and pyrazole rings at the edges...
December 5, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27917520/sensitive-enhancement-of-vessel-wall-imaging-with-an-endoesophageal-wireless-amplified-nmr-detector-wand
#16
Xianchun Zeng, Mladen Barbic, Liangliang Chen, Chunqi Qian
PURPOSE: To improve the imaging quality of vessel walls with an endoesophageal Wireless Amplified NMR Detector (WAND). METHODS: A cylindrically shaped double-frequency resonator has been constructed with a single metal wire that is self-connected by a pair of nonlinear capacitors. The double-frequency resonator can convert wirelessly provided pumping power into amplified MR signals. This compact design makes the detector easily insertable into a rodent esophagus...
December 4, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27917254/designing-an-affordable-wire-navigation-surgical-simulator
#17
Steven Long, Geb W Thomas, Donald D Anderson
No abstract text is available yet for this article.
September 2016: Journal of Medical Devices
https://www.readbyqxmd.com/read/27916917/a-routing-protocol-for-multisink-wireless-sensor-networks-in-underground-coalmine-tunnels
#18
Xu Xia, Zhigang Chen, Hui Liu, Huihui Wang, Feng Zeng
Traditional underground coalmine monitoring systems are mainly based on the use of wired transmission. However, when cables are damaged during an accident, it is difficult to obtain relevant data on environmental parameters and the emergency situation underground. To address this problem, the use of wireless sensor networks (WSNs) has been proposed. However, the shape of coalmine tunnels is not conducive to the deployment of WSNs as they are long and narrow. Therefore, issues with the network arise, such as extremely large energy consumption, very weak connectivity, long time delays, and a short lifetime...
November 30, 2016: Sensors
https://www.readbyqxmd.com/read/27915360/patient-safety-organizations-and-emergency-medical-services
#19
William J Leggio, Lee Varner, Kathryn Wire
Providing safe and error-free patient care should resonate well with all healthcare providers including emergency medical technicians. The environments and circumstances in which emergency medical services (EMS) provide patient care inevitably create risks to both the provider and patient. This article explores the concepts of patient safety, errors, near misses, adverse events, and Just Culture. Literature raises concerns about the lack of data collection on both patient and provider safety and research on these safety topics in EMS...
2016: Journal of Allied Health
https://www.readbyqxmd.com/read/27914840/coracoclavicular-stabilization-using-a-suture-button-device-for-neer-type-iib-lateral-clavicle-fractures
#20
Chul-Hyun Cho, Jae-Hoon Jung, Beom-Soo Kim
BACKGROUND: The purpose of this study was to evaluate the radiologic and clinical outcomes of coracoclavicular (CC) stabilization using a suture button device for Neer type IIB lateral clavicle fractures. METHODS: Eighteen consecutive patients with Neer type IIB fractures were treated with CC stabilization using a TightRope device (Arthrex, Naples, FL, USA). The mean follow-up period was 46.6 months (range, 24-75 months). Radiologic outcomes were assessed using serial plain radiographs...
November 30, 2016: Journal of Shoulder and Elbow Surgery
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