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https://www.readbyqxmd.com/read/29340993/laparoscopic-assisted-modified-intersphincter-resection-for-ultralow-rectal-cancer
#1
Haiyang Zhou, Canping Ruan, Zhiguo Wang, Zhiqian Hu
BACKGROUND: Intersphincter resection (ISR) is considered to be a superior technique offering sphincter preservation in patients with ultralow rectal cancer.1 Because high-definition laparoscopy offers wider and clearer vision into the narrow pelvic cavity and intersphincteric space, ISR has been further refined.2 However, functional outcome after ISR has not been optimal. More than half of patients receiving ISR suffer partial or even complete anal incontinence.3 We therefore propose a laparoscopic-assisted modified ISR, with the aim of improving sphincter function following ISR...
January 16, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29334733/surface-functionalization-with-carboxylic-acids-by-photochemical-microcontact-printing-and-tetrazole-chemistry
#2
Christoph Buten, Sebastian Lamping, Martin Körsgen, Heinrich F Arlinghaus, Craig Jamieson, Bart Jan Ravoo
In this paper we show that carboxylic acid functionalized molecules can be patterned by photochemical microcontact printing on tetrazole-terminated self-assembled monolayers. Upon irradiation, tetrazoles eliminate nitrogen to form highly reactive nitrile imines, which can be ligated with several different nucleophiles, carboxylic acids being most reactive. As a proof of concept, we immobilized trifluoroacetic acid to monitor the reaction with X-ray photoelectron spectroscopy (XPS). Moreover, we also immobilized peptides and fabricated carbohydrate-lectin as well as biotin-streptavidin microarrays using this method...
January 16, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29298403/intrapulpal-temperature-increases-caused-by-445-nm-diode-laser-assisted-debonding-of-self-ligating-ceramic-brackets-during-simulated-pulpal-fluid-circulation
#3
Steffen Stein, Johannes Wenzler, Andreas Hellak, Michael Schauseil, Heike Korbmacher-Steiner, Andreas Braun
OBJECTIVE: This study investigated temperature increases in dental pulp resulting from laser-assisted debonding of ceramic brackets using a 445-nm diode laser. MATERIALS AND METHODS: Eighteen ceramic brackets were bonded in standardized manner to 18 caries-free human third molars. Pulpal fluid circulation was simulated by pumping distilled water at 37°C through the pulp chamber. The brackets were irradiated with a 445-nm diode laser. Temperatures were measured using a thermal camera at points P1 (center of the pulp) and P2 (in the hard dental tissue) at the baseline (T0), at the start and end of laser application (T1 and T2), and the maximum during the sequence (Tmax)...
January 3, 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29280233/operant-self-administration-of-pregabalin-in-a-mouse-model-of-neuropathic-pain
#4
S A Bura, D Cabañero, R Maldonado
BACKGROUND: Pregabalin is a first-line agent for neuropathic pain treatment whose abuse liability remains controversial. Surprisingly, studies exploring the reinforcing properties of pregabalin in operant mouse models are missing. METHODS: We evaluated the acquisition of operant pregabalin self-administration in mice exposed to a partial sciatic nerve ligation (PSNL) or a sham operation. After surgery, mice were trained in operant boxes to intravenously self-administer pregabalin at 1...
December 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29279684/self-ligating-versus-conventional-metallic-brackets-on-streptococcus-mutans-retention-a-systematic-review
#5
Juliano N Longoni, Beatriz M Lopes, Irlan A Freires, Kamile L Dutra, Ademir Franco, Luiz R Paranhos
Objective: The present study aimed to review the literature systematically and assess comparatively whether self-ligating metallic brackets accumulate less Streptococcus mutans biofilm than conventional metallic brackets. Material and methods: The systematic search was performed following PRISMA guidelines and registration in PROSPERO. Seven electronic databases (Google Scholar, LILACS, Open Grey, PubMed, SciELO, ScienceDirect, and Scopus) were consulted until April 2016, with no restriction of language and time of publication...
October 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/29275568/-effects-of-t-helper-1-cells-and-t-helper-17-cells-secreting-cytokines-on-rat-models-of-experimental-periodontitis
#6
Z X Wang, L Yang, J Y Tan, L L Chen
Objectvie: To investigate the effects of secreting cytokines interferon-gamma (IFN-γ) and interleukin-17 (IL-17) of T helper 1 cells (Th1) and T helper 17 cells (Th17) on the peripheral blood and alveolar bone destruction, so as to provide a new explanation for cellular immunity-mediated alveolar bone destruction. Methods: Eighteen eight-week-old male Sprague-Dawley rats were divided, randomly and equally, into 3 groups: lipopolysaccharide (LPS) group, ligation group and normal control group. In the LPS group, Escherichia coli LPS was injected into the alveolar mucosa on the buccalmedian site of the left upper first molar, while the right upper first molar was injected with equal volume of physiological saline as self-controls...
December 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/29239329/activation-of-the-akt-mtor-signaling-pathway-a-potential-response-to-long-term-neuronal-loss-in-the-hippocampus-after-sepsis
#7
Jia-Nan Guo, Lin-Yu Tian, Wen-Yu Liu, Jie Mu, Dong Zhou
Survivors of sepsis may suffer chronic cognitive impairment as a long-term sequela. However, the precise mechanisms of cognitive dysfunction after sepsis are not well understood. We employed the cecal ligation-and-puncture-induced septic mouse model. We observed elevated phosphorylation of Akt, mammalian target of rapamycin (mTOR) and p70S6K on days 14 and 60, progressive neuronal loss in the cornu ammonis 1 region, and abnormal neuronal morphology in the hippocampus in the sepsis mouse model. These findings indicate that changes in neuronal morphology and number in the hippocampus after sepsis were associated with strong activation of the Akt/mTOR signaling pathway, and may reflect a "self-rescuing" feedback response to neuronal loss after sepsis...
November 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29215120/searching-for-avidity-by-chemical-ligation-of-combinatorially-self-assembled-dna-encoded-ligand-libraries
#8
Stefan Matysiak, Klaus Hellmuth, Afaf H El-Sagheer, Arun Shivalingam, Yavuz Ariyurek, Marco de Jong, Martine J Hollestelle, Ruud Out, Tom Brown
DNA encoded ligands are self-assembled into bivalent complexes and chemically ligated to link their identities. To demonstrate their potential as a combinatorial screening platform for avidity interactions, the optimal bivalent aptamer design (examplar ligands) for human alpha-thrombin is determined in a single round of selection and the DNA scaffold replaced with minimal impact on the final design.
December 7, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29208799/an-alternative-approach-for-space-opening-in-a-bilateral-maxillary-lateral-incisor-agenesis-patient-using-miniplates
#9
Gladistone C Meros, Aline Shoji, Selly Suzuki, Luiz R Paranhos, Rodrigo Manfroi, Jonathas Claus, Aguinaldo Garcez
AIM: This case report aimed to present an orthodontic mechanic alternative for space opening in a patient missing maxillary lateral incisors, using miniplates as anchorage, associated with self-ligating brackets. BACKGROUND: Dental agenesis affects the population causing esthetic and functional damages. The prevalence of missing maxillary lateral incisors should be considered for its significant rate and negative impact on smile esthetics. CASE REPORT: This treatment was chosen based on the presence of balanced facial pattern, large canine anatomy, the need to improve dental occlusion to prevent further wear, and patient's esthetic complaint...
December 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29181290/expanding-the-molecular-ruler-process-through-vapor-deposition-of-hexadecanethiol
#10
Alexandra M Patron, Timothy S Hooker, Daniel F Santavicca, Corey P Causey, Thomas J Mullen
The development of methods to produce nanoscale features with tailored chemical functionalities is fundamental for applications such as nanoelectronics and sensor fabrication. The molecular-ruler process shows great utility for this purpose as it combines top-down lithography for the creation of complex architectures over large areas in conjunction with molecular self-assembly, which enables precise control over the physical and chemical properties of small local features. The molecular-ruler process, which most commonly uses mercaptoalkanoic acids and metal ions to generate metal-ligated multilayers, can be employed to produce registered nanogaps between metal features...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29170961/a-modified-gibson-assembly-method-for-cloning-large-dna-fragments-with-high-gc-contents
#11
Lei Li, Weihong Jiang, Yinhua Lu
Gibson one-step, isothermal assembly method (Gibson assembly) can be used to efficiently assemble large DNA molecules by in vitro recombination involving a 5'-exonuclease, a DNA polymerase and a DNA ligase. In the past few years, this robust DNA assembly method has been widely applied to seamlessly construct genes, genetic pathways and even entire genomes. Here, we expand this method to clone large DNA fragments with high GC contents, such as antibiotic biosynthetic gene clusters from Streptomyces . Due to the low isothermal condition (50 °C) in the Gibson reaction system, the complementary overlaps with high GC contents are proposed to easily form mismatched linker pairings, which leads to low assembly efficiencies mainly due to vector self-ligation...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29160347/stability-comparison-of-two-different-dentoalveolar-expansion-treatment-protocols
#12
Ezgi Atik, Tülin Taner
OBJECTIVE: The aim of this study was to compare the longitudinal stability of the conventional straight-wire system after the use of a quad-helix appliance with Damon self-ligating system in patients with Class I malocclusion. METHODS: 27 adolescent patients were evaluated at three different periods: pre-treatment (T1), post-treatment (T2) and three years post-treatment (T3). Group 1 included 12 patients (with a mean age of 14.65 year) treated with Damon 3MX bracket system; and Group 2 included 15 patients (with a mean age of 14...
September 2017: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/29130230/-protective-measures-in-laparoscopic-resection-for-upper-or-mid-rectal-cancer-and-sigmoid-colon-cancer-with-transrectal-specimen-extraction-surgery
#13
Chuangang Fu, Zhuqing Zhou, Junyi Han, Bin Lu, Wei Gao, Zhe Zhu, Qixin Jiang, Fang Ji, Tao Du
OBJECTIVE: To introduce the use of a self-made specimen protective sleeve in laparoscopic resection for upper or mid rectal cancer and sigmoid colon cancer with transrectal specimen extraction surgery and the improvement of implantation method, so as to avoid and reduce bacterial contamination and tumor cell dissemination in abdominal cavity. METHODS: During June 2015 and May 2017, 48 cases of high located rectal or sigmoid colon cancer were operated laparoscopically with natural orifices specimen extraction surgery (NOSES) using a self-made specimen protecting sleeve...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29126321/reciprocal-nucleopeptides-as-the-ancestral-darwinian-self-replicator
#14
Eleanor F Banwell, Bernard M A G Piette, Anne Taormina, Jonathan G Heddle
Even the simplest organisms are too complex to have spontaneously arisen fully-formed, yet precursors to first life must have emerged ab initio from their environment. A watershed event was the appearance of the first entity capable of evolution: the Initial Darwinian Ancestor. Here we suggest that nucleopeptide reciprocal replicators could have carried out this important role and contend that this is the simplest way to explain extant replication systems in a mathematically consistent way. We propose short nucleic- acid templates on which amino-acylated adapters assembled...
November 8, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29109766/cancer-nanomedicines-stabilized-by-%C3%AF-%C3%AF-stacking-between-heterodimeric-prodrugs-enable-exceptionally-high-drug-loading-capacity-and-safer-delivery-of-drug-combinations
#15
Hangxiang Wang, Jianmei Chen, Chang Xu, Linlin Shi, Munire Tayier, Jiahui Zhou, Jun Zhang, Jiaping Wu, Zhijian Ye, Tao Fang, Weidong Han
Combination therapy using distinct mode-of-action drugs has sparked a rapidly growing interest because this paradigm holds promise for improving the therapeutic efficacy of anticancer therapy. However, the current drug combination therapy refers to administering individual drugs together, which is far from a perfect regimen for cancer patients. The aim of this work was to demonstrate that synergistic delivery of two chemotherapeutic drugs in a single nanoparticle reservoir could be achieved through the rational chemical ligation of the drugs followed by supramolecular nano-assembly via blending of the drugs with a minimal amount of matrix...
2017: Theranostics
https://www.readbyqxmd.com/read/29103440/effects-of-low-level-laser-irradiation-on-the-rate-of-orthodontic-tooth-movement-and-associated-pain-with-self-ligating-brackets
#16
RANDOMIZED CONTROLLED TRIAL
Irfan Qamruddin, Mohammad Khursheed Alam, Verda Mahroof, Mubassar Fida, Mohd Fadhli Khamis, Adam Husein
INTRODUCTION: The aim of this study was to evaluate the effect of low-level laser irradiation applied at 3-week intervals on orthodontic tooth movement and pain associated with orthodontic tooth movement using self-ligating brackets. METHODS: Twenty-two patients (11 male, 11 female; mean age, 19.8 ± 3.1 years) with Angle Class II Division 1 malocclusion were recruited for this split-mouth clinical trial; they required extraction of maxillary first premolars bilaterally...
November 2017: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/29101414/transversal-changes-space-closure-and-efficiency-of-conventional-and-self-ligating-appliances-a-quantitative-systematic-review
#17
Xianrui Yang, Chaoran Xue, Yiruo He, Mengyuan Zhao, Mengqi Luo, Peiqi Wang, Ding Bai
OBJECTIVE: Self-ligating brackets (SLBs) were compared to conventional brackets (CBs) regarding their effectiveness on transversal changes and space closure, as well as the efficiency of alignment and treatment time. METHODS: All previously published randomized controlled clinical trials (RCTs) dealing with SLBs and CBs were searched via electronic databases, e.g., MEDLINE, Cochrane Central Register of Controlled Trials, EMBASE, World Health Organization International Clinical Trials Registry Platform, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure...
November 3, 2017: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
https://www.readbyqxmd.com/read/29097301/non-enzymatic-recombination-of-rna-ligation-in-loops
#18
Staroseletz Yaroslav, Sergey Nechaev, Elena Bichenkova, Richard A Bryce, Catherine Watson, Valentin Vlassov, Marina Zenkova
BACKGROUND: While the RNA world hypothesis is widely accepted, it is still far from complete: the existence of self-replicating ribozyme, consisting of potentially hundreds of nucleotides, is a core assumption for the majority of RNA world models. The appearance of such long RNA molecules under prebiotic conditions is not self-evident. Recombination seems to be a plausible way of creating RNA diversity, resulting in the appearance of functional RNAs, capable of self-replicating. METHODS: We report here on the study of recombination process modelled with two 96 nts RNA fragments...
October 30, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29094480/myocardial-infarction-does-not-affect-circulating-hematopoietic-stem-and-progenitor-cell-self-renewal-ability-in-a-rat-model
#19
J M Kröpfl, C M Spengler, A Frobert, G Ajalbert, M N Giraud
Due to the importance of peripheral blood hematopoietic stem and progenitor cells (HPCs) in post-acute regeneration after acute myocardial infarction (MI), the present study aimed to investigate count and secondary replating capacity/self-renewal ability of HPCs in peripheral blood before and two weeks after MI. In nine female Lewis inbred rats (n = 9), myocardial infarction was induced by ligation of the left coronary artery while another nine had surgery without ligation for control purposes. Myocardial infarction was confirmed by troponin I concentrations 24 h after MI...
November 2, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29048162/cytochrome-c-as-a-peroxidase-activation-of-the-precatalytic-native-state-by-h2o2-induced-covalent-modifications
#20
Victor Yin, Gary S Shaw, Lars Konermann
In addition to serving as respiratory electron shuttle, ferri-cytochrome c (cyt c) acts as a peroxidase; i.e., it catalyzes the oxidation of organic substrates by H2O2. This peroxidase function plays a key role during apoptosis. Typical peroxidases have a five-coordinate heme with a vacant distal coordination site that permits the iron center to interact with H2O2. In contrast, native cyt c is six-coordinate, as the distal coordination site is occupied by Met80. It thus seems counterintuitive that native cyt c would exhibit peroxidase activity...
November 8, 2017: Journal of the American Chemical Society
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