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https://www.readbyqxmd.com/read/28231426/engineering-of-anti-cd133-tri-specific-molecule-capable-of-inducing-nk-expansion-and-driving-antibody-dependent-cell-mediated-cytotoxicity-adcc
#1
Jörg U Schmohl, Martin Felices, Felix Oh, Alexander J Lenvik, Aaron M Lebeau, Jayanth Panyam, Jeffrey S Miller, Daniel A Vallera
Purpose: The selective elimination of cancer stem cells (CSCs) in tumor patients is a crucial goal because CSCs cause drug refractory relapse. To improve the current conventional bispecific immune-engager platform, a 16133 BiKE, consisting of scFvs binding FcγRIII (CD16) on NK cells and CD133 on carcinoma cells, was first synthesized and a modified IL-15 crosslinker capable of stimulating NK effector cells was introduced. Materials and Methods: DNA shuffling and ligation techniques were used to assemble and synthesize the 1615133 trispecific NK cell engager (TriKE)...
February 20, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28224175/differences-between-active-and-passive-self-ligating-brackets-for-orthodontic-treatment-systematic-review-and-meta-analysis-based-on-randomized-clinical-trials
#2
Xianrui Yang, Yiruo He, Tian Chen, Mengyuan Zhao, Yinqiu Yan, Hongzhe Wang, Ding Bai
PURPOSE: In orthodontic treatment, the effects of differences in the design between active and passive self-ligating bracket (ASLB and PSLB, respectively) are usually neglected. This study investigated differences in effectiveness and efficiency between ASLBs and PSLBs. METHODS: To identify randomized, controlled clinical trials (RCTs) comparing ASLB with PSLB, the electronic databases Medline, Embase, Cochrane Central Register of Controlled Trials, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, and Chinese Medical Journal Database were searched without language or time limits...
February 21, 2017: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
https://www.readbyqxmd.com/read/28182009/hetero-oligomerization-between-the-tnf-receptor-superfamily-members-cd40-fas-and-trailr2-modulate-cd40-signalling
#3
Cristian R Smulski, Marion Decossas, Neila Chekkat, Julien Beyrath, Laure Willen, Gilles Guichard, Raquel Lorenzetti, Marta Rizzi, Hermann Eibel, Pascal Schneider, Sylvie Fournel
TNF receptor superfamily members (TNFRSF) such as CD40, Fas and TRAIL receptor 2 (TRAILR2) participate to the adaptive immune response by eliciting survival, proliferation, differentiation and/or cell death signals. The balance between these signals determines the fate of the immune response. It was previously reported that these receptors are able to self-assemble in the absence of ligand through their extracellular regions. However, the role of this oligomerization is not well understood, and none of the proposed hypotheses take into account potential hetero-association of receptors...
February 9, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28149476/torque-expression-in-self-ligating-orthodontic-brackets-and-conventionally-ligated-brackets-a-systematic-review
#4
REVIEW
Yousef Al-Thomali, Roshan-Noor Mohamed, Sakeenabi Basha
BACKGROUND: To evaluate the torque expression of self ligating (SL) orthodontic brackets and conventionally ligated brackets and the torque expression in active and passive SL brackets. MATERIAL AND METHODS: Our systematic search included MEDLINE, EMBASE, CINAHL, PsychINFO, Scopus, and key journals and review articles; the date of the last search was April 4th 2016. We graded the methodological quality of the studies by means of the Quality Assessment Tool for Quantitative Studies, developed for the Effective Public Health Practice Project (EPHPP)...
January 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28127535/mandibular-arch-orthodontic-treatment-stability-using-passive-self-ligating-and-conventional-systems-in-adults-a-randomized-controlled-trial
#5
Norma Ab Rahman, Mang Chek Wey, Siti Adibah Othman
OBJECTIVE: This randomized controlled trial aimed to compare the stability of mandibular arch orthodontic treatment outcomes between passive self-ligating and conventional systems during 6 months of retention. METHODS: Fortyseven orthodontic patients with mild to moderate crowding malocclusions not requiring extraction were recruited based on inclusion criteria. Patients (mean age 21.58 ± 2.94 years) were randomized into two groups to receive either passive self-ligating (Damon® 3MX, n = 23) or conventional system (Gemini MBT, n = 24) orthodontic treatment...
January 2017: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/28125144/evaluation-of-force-released-by-deflection-of-orthodontic-wires-in-conventional-and-self-ligating-brackets
#6
Rodrigo Hitoshi Higa, Nayara Thiago Semenara, José Fernando Castanha Henriques, Guilherme Janson, Renata Sathler, Thais Maria Freire Fernandes
Introduction: The aim of the study was to evaluate deflection forces of rectangular orthodontic wires in conventional (MorelliTM), active (In-Ovation RTM) and passive (Damon 3MXTM) self-ligating brackets. Material and Methods: Two brands of stainless steel and nickel-titanium (NiTi) wires (MorelliTM and GACTM), in addition to OrmcoTM copper-nickel-titanium wires were used. Specimens were assembled in a clinical simulation device especially designed for this study and tested in an Instron universal testing machine...
November 2016: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/28122887/expanding-the-genetic-spectrum-of-anos1-mutations-in-patients-with-congenital-hypogonadotropic-hypogonadism
#7
C I Gonçalves, F Fonseca, T Borges, F Cunha, M C Lemos
STUDY QUESTION: What is the prevalence and functional consequence of ANOS1 (KAL1) mutations in a group of men with congenital hypogonadotropic hypogonadism (CHH)? SUMMARY ANSWER: Three of forty-two (7.1%) patients presented ANOS1 mutations, including a novel splice site mutation leading to exon skipping and a novel contiguous gene deletion associated with ichthyosis. WHAT IS KNOWN ALREADY: CHH is characterized by lack of pubertal development and infertility, due to deficient production, secretion or action of GnRH, and can be associated with anosmia/hyposmia (Kallmann syndrome, KS) or with a normal sense of smell (normosmic CHH)...
January 24, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28076292/445-nm-diode-laser-assisted-debonding-of-self-ligating-ceramic-brackets
#8
Steffen Stein, Alexander Kleye, Michael Schauseil, Andreas Hellak, Heike Korbmacher-Steiner, Andreas Braun
OBJECTIVES: This study determined the influence of irradiation on aesthetic ceramic brackets with a novel 445-nm diode laser prior to debonding on the bracket failure mode. MATERIALS AND METHODS: Thirty ceramic brackets (In-Ovation® C, GAC) were standard-bonded to the oral and buccal planed and polished enamel surfaces of 15 caries-free human 3rd molars. Prior to study-blinded debonding, the brackets in the laser group were irradiated with the diode laser (SIROLaser Blue®, Sirona), while the irradiation was simulated within the conventional group...
January 11, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28056928/new-ligation-independent-cloning-vectors-for-expression-of-recombinant-proteins-with-a-self-cleaving-cpd-6xhis-tag
#9
Marco Biancucci, Jazel S Dolores, Jennifer Wong, Sarah Grimshaw, Wayne F Anderson, Karla J F Satchell, Keehwan Kwon
BACKGROUND: Recombinant protein purification is a crucial step for biochemistry and structural biology fields. Rapid robust purification methods utilize various peptide or protein tags fused to the target protein for affinity purification using corresponding matrices and to enhance solubility. However, affinity/solubility-tags often need to be removed in order to conduct functional and structural studies, adding complexities to purification protocols. RESULTS: In this work, the Vibrio cholerae MARTX toxin Cysteine Protease Domain (CPD) was inserted in a ligation-independent cloning (LIC) vector to create a C-terminal 6xHis-tagged inducible autoprocessing enzyme tag, called "the CPD-tag"...
January 5, 2017: BMC Biotechnology
https://www.readbyqxmd.com/read/28052623/prevention-and-treatment-of-variceal-haemorrhage-in-2017
#10
REVIEW
Felix Brunner, Annalisa Berzigotti, Jaime Bosch
Variceal haemorrhage is a major complication of portal hypertension that still causes high mortality in patients with cirrhosis. Improved knowledge of the pathophysiology of portal hypertension has recently led to a more comprehensive approach to prevent all the complications of this condition. Thus, optimal treatment of portal hypertension requires a strategy that takes into account the clinical stage of the disease and all the major variables that affect the risk of progression to the next stage and death...
January 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28029202/three-dimensional-ordered-antibody-arrays-through-self-assembly-of-antibody-polymer-conjugates
#11
Xue-Hui Dong, Allie C Obermeyer, Bradley D Olsen
Three-dimensional (3D) ordered arrays of human immunoglobulin G (IgG) were fabricated using well-defined full-length antibody-polymer conjugates (APCs). The conjugates were prepared through a two-step sequential click approach with a combination of oxime ligation and strain promoted alkyne-azide cycloaddition. They were able to self-assemble into lamellar nanostructures with alternating IgG and poly(N-isopropylacrylamide) (PNIPAM) nanodomains. As a proof-of-concept, these materials were fabricated into thin films and their specific binding ability was tested...
December 28, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/28026928/harnessing-photovoltage-effects-of-film-thickness-tio2-nanoparticle-size-mgo-and-surface-capping-with-dscs
#12
Hammad Cheema, Jared H Delcamp
High photovoltage dye-sensitized solar cells (DSCs) offer an exceptional opportunity to power electrocatalysts for the production of hydrogen from water and the reduction of CO2 to usable fuels with a relatively cost-effective, low-toxicity solar cell. Competitive recombination pathways such as electron transfer from TiO2 films to the redox shuttle or oxidized dye must be minimized to achieve the maximum possible photovoltage (Voc) from DSC devices. A high Voc of 882 mV was achieved with the iodide/triiodide redox shuttle and a ruthenium NCS-ligated dye, HD-2-mono, by utilizing a combined approach of (1) modulating the TiO2 surface area through film thickness and nanoparticle size selection, (2) addition of a MgO insulating layer, and (3) capping available TiO2 film surface sites post film sensitization with an F-SAM (fluorinated self-assembled monolayer) treatment...
January 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28008983/scaffold-free-bio-orthogonal-assembly-of-3-dimensional-cardiac-tissue-via-cell-surface-engineering
#13
Dmitry Rogozhnikov, Paul J O'Brien, Sina Elahipanah, Muhammad N Yousaf
There has been tremendous interest in constructing in vitro cardiac tissue for a range of fundamental studies of cardiac development and disease and as a commercial system to evaluate therapeutic drug discovery prioritization and toxicity. Although there has been progress towards studying 2-dimensional cardiac function in vitro, there remain challenging obstacles to generate rapid and efficient scaffold-free 3-dimensional multiple cell type co-culture cardiac tissue models. Herein, we develop a programmed rapid self-assembly strategy to induce specific and stable cell-cell contacts among multiple cell types found in heart tissue to generate 3D tissues through cell-surface engineering based on liposome delivery and fusion to display bio-orthogonal functional groups from cell membranes...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27973783/optimized-long-range-corrected-density-functionals-for-electronic-and-optical-properties-of-bare-and-ligated-cdse-quantum-dots
#14
O S Bokareva, M F Shibl, M J Al-Marri, T Pullerits, O Kühn
The reliable prediction of optical and fundamental gaps of finite size systems using density functional theory requires to account for the potential self-interaction error, which is notorious for degrading the description of charge transfer transitions. One solution is provided by parametrized long-range corrected functionals such as LC-BLYP, which can be tuned such as to describe certain properties of the particular system at hand. Here, bare and 3-mercaptoprotionic acid covered Cd33Se33 quantum dots are investigated using the optimally tuned LC-BLYP functional...
December 29, 2016: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/27915483/factors-associated-with-sterilization-among-hiv-positive-us-women-in-an-urban-outpatient-clinic
#15
V T Raziano, A N Smoots, L B Haddad, K M Wall
This cross-sectional study sought to determine factors associated with sterilization among HIV-positive US women. HIV-positive women aged 18-45 completed an Audio Computer Assisted Self Interview (ACASI) questionnaire. Chi-square tests and multivariable logistic regression evaluated factors associated with sterilization. The median age of the 187 participants was 37, the majority had at least a high school education, and 88% were African American. Nearly a quarter (22%) of women had undergone sterilization at an average age of 25; of these women, 71% cited their HIV-positive status as an important factor in deciding to have a tubal ligation, 22% expressed desire for future children, 32% reported sterilization regret, and 20% reported feeling pressure to undergo sterilization...
December 4, 2016: AIDS Care
https://www.readbyqxmd.com/read/27901234/air-powder-polishing-on-self-ligating-brackets-after-clinical-use-effects-on-debris-levels
#16
Mônica L S Castro Aragón, Leandro Santiago Lima, David Normando
Introduction: Debris buildup on brackets and arch surfaces is one of the main factors that can influence the intensity of friction between bracket and orthodontic wire. Objective: This study sought to evaluate the effect of air-powder polishing cleaning on debris levels of self-ligating ceramic brackets at the end of orthodontic treatment, compared to the behavior of conventional brackets. Methods: Debris levels were evaluated in metal conventional orthodontic brackets (n = 42) and ceramic self-ligating brackets (n = 42) on canines and premolars, arranged in pairs...
September 2016: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/27875848/multimodal-therapy-of-recurrent-and-refractory-bleeding-from-esophageal-varices-case-report-and-review-of-the-literature
#17
M Buechter, V Penndorf, A Canbay, J M Theysohn, A Dechêne
Bleeding from esophageal varices is a major cause of mortality in patients with advanced liver disease. Although standard treatment and secondary prophylaxis are effective, in some patients sustained hemostasis cannot be achieved. We report the case of a woman with alcoholic liver disease in whom pharmacological, endoscopic, and intravascular therapies failed to control variceal bleeding. Only a combination of (repeated) band ligation, insertion of a self-expanding metal stent, TIPS implantation and redilatation, transjugular variceal embolization, and finally implantation of a portocaval shunt proved to be successful...
December 2016: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/27871255/root-resorption-during-orthodontic-treatment-with-self-ligating-or-conventional-brackets-a-systematic-review-and-meta-analysis
#18
Jianru Yi, Meile Li, Yu Li, Xiaobing Li, Zhihe Zhao
BACKGROUND: The aim of this study was to compare the external apical root resorption (EARR) in patients receiving fixed orthodontic treatment with self-ligating or conventional brackets. METHODS: Studies comparing the EARR between orthodontic patients using self-ligating or conventional brackets were identified through electronic search in databases including CENTRAL, PubMed, EMBASE, China National Knowledge Infrastructure (CNKI) and SIGLE, and manual search in relevant journals and reference lists of the included studies until Apr 2016...
November 21, 2016: BMC Oral Health
https://www.readbyqxmd.com/read/27852702/gas6-axl-signaling-regulates-self-renewal-of-chronic-myelogenous-leukemia-stem-cells-by-stabilizing-%C3%AE-catenin
#19
Yanli Jin, Danian Nie, Juan Li, Xin Du, Yuhong Lu, Yangqiu Li, Chang Liu, Jingfeng Zhou, Jingxuan Pan
PURPOSE: Quiescent leukemia stem cells (LSCs) are important resources of resistance and relapse in chronic myelogenous leukemia (CML). Thus, strategies eradicating CML LSCs are required for cure. In this study, we discovered that AXL tyrosine kinase was selectively overexpressed in primary CML CD34+ cells. However, the role of AXL and its ligand Gas6 secreted by stromal cells in the regulation of self-renewal capacity of LSCs has not been well investigated. EXPERIMENTAL DESIGN: The function of CML CD34+ cells was evaluated by flow cytometer, CFC/replating, long-term culture-initiating cells (LTC-IC), CML mouse model driven by human BCR-ABL gene and NOD-scid-IL2Rg-/- (NSI) mice...
November 16, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27817190/high-frequency-targeted-mutagenesis-in-pseudomonas-stutzeri-using-a-vector-free-allele-exchange-protocol
#20
Ahmed E Gomaa, Zhiping Deng, Zhimin Yang, Liguo Shang, Yuhua Zhan, Wei Lu, Min Lin, Yongliang Yan
The complexity of the bacterial recombination system is a barrier for the construction of bacterial mutants for the further functional investigation of specific genes. Several protocols have been developed to inactivate genes from the genus Pseudomonas. Those protocols are complicated and time-consuming and mostly do not enable easy construction of multiple knock-ins/outs. The current study describes a single and double crossover-recombination system using an optimized Vector-Free Allele Exchange (VFAE) protocol for gene disruption and gene replacement in a single species of the family Pseudomonadaceae...
November 4, 2016: Journal of Microbiology and Biotechnology
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