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obesity and pregnancy

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https://www.readbyqxmd.com/read/29456871/gestational-obesity-weight-management-implementation-of-national-guidelines-glowing-a-pilot-cluster-randomised-controlled-trial-of-a-guideline-implementation-intervention-for-the-management-of-maternal-obesity-by-midwives
#1
Nicola Heslehurst, Judith Rankin, Catherine McParlin, Falko F Sniehotta, Denise Howel, Stephen Rice, Elaine McColl
Background: Weight management in pregnancy guidelines exist, although dissemination alone is an ineffective means of implementation. Midwives identify the need for support to overcome complex barriers to practice. An evaluation of an intervention to support midwives' guideline implementation would require a large-scale cluster randomised controlled trial. A pilot study is necessary to explore the feasibility of delivery and evaluation prior to a definitive trial. The GestationaL Obesity Weight management: Implementation of National Guidelines (GLOWING) trial aims to test whether it is feasible and acceptable to deliver a behaviour change intervention to support midwives' implementation of weight management guidelines...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29455384/novel-interventions-to-reduce-stress-and-overeating-in-overweight-pregnant-women-a-feasibility-study
#2
B A Laraia, N E Adler, K Coleman-Phox, C Vieten, L Mellin, J L Kristeller, M Thomas, N E Stotland, R H Lustig, M F Dallman, F M Hecht, N R Bush, C L de Groat, E Epel
Background High stress and depression during pregnancy are risk factors for worsened health trajectories for both mother and offspring. This is also true for pre-pregnancy obesity and excessive gestational weight gain. Reducing stress and depression may be one path to prevent excessive caloric intake and gestational weight gain. Study Purpose We tested the feasibility of two novel interventions aimed at reducing stress and overeating during pregnancy. Reflecting different theoretical underpinnings, the interventions target different mechanisms...
February 17, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29454871/maternal-and-neonatal-outcomes-after-bariatric-surgery-a-systematic-review-and-meta-analysis-do-the-benefits-outweigh-the-risks
#3
REVIEW
Wilson Kwong, George Tomlinson, Denice S Feig
OBJECTIVE: Obesity during pregnancy is associated with a number of adverse obstetrical outcomes, including gestational diabetes, macrosomia and preeclampsia. There is increasing evidence that bariatric surgery may decrease the risk of these outcomes. Our aim was to evaluate the benefits and risks of bariatric surgery in obese women on obstetrical outcomes. DATA SOURCES: A systematic literature search using MEDLINE, Embase, Cochrane, Web of Science and PubMed from inception up to December 12, 2016...
February 15, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29450794/association-between-obstetric-provider-s-advice-and-gestational-weight-gain
#4
Andrea Lopez-Cepero, Katherine Leung, Tiffany Moore Simas, Milagros C Rosal
Objective This study examined associations between pregnant women's report of obstetric provider GWG advice, self-reported adherence to such advice, and GWG. Methods Healthy pregnant women (N = 91) who started obstetric care prior to 17 weeks of gestation completed assessments between 30 and 34 weeks of gestation. These included survey (questions on receipt of and adherence to provider GWG advice, and demographics) and anthropometric measures. GWG data were abstracted from electronic health records. Analyses included Chi square and Mann-Whitney tests, and binary and multivariate logistic regressions...
February 15, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29447091/obesity-in-pregnancy-a-comparison-of-four-national-guidelines
#5
Dana Vitner, Kristin Harris, Cynthia Maxwell, M D Farine
BACKGROUND: Obesity in pregnancy has become one of the most important challenges in obstetrical care given its prevalence and potential adverse impact on both mother and fetus. The primary objective of this descriptive review is to identify common themes and distinctions within the current recommendations for maternal obesity in the most updated version of four published national guidelines. METHODS: We reviewed the following guidelines for obesity in pregnancy: American College of Obstetricians and Gynecologists (ACOG) 2015, Royal Australian and New Zealand College of Obstetricians and Gynecologists (RANZCOG) 2013, Royal College of Obstetrics and Gynecology (RCOG) 2010, and Society of Obstetrics and Gynecologists of Canada (SOGC) 2010...
February 15, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29438637/population-attributable-fractions-of-perinatal-outcomes-for-nulliparous-women-associated-with-overweight-and-obesity-1990-2014
#6
Kate Cheney, Rachel Farber, Alexandra L Barratt, Kevin McGeechan, Bradley de Vries, Robert Ogle, Kirsten I Black
OBJECTIVE: To examine the prevalence across 25 years of overweight and obesity among nulliparous Australian women during early pregnancy; to estimate the proportions of adverse perinatal outcomes attributable to overweight and obesity in this population. DESIGN: Cohort study; retrospective analysis of electronic maternity data. Setting, participants: 42 582 nulliparous women with singleton pregnancies giving birth at the Royal Prince Alfred Hospital, an urban teaching hospital in Sydney, January 1990 - December 2014...
February 19, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29438518/obesity-and-high-fat-diet-induce-distinct-changes-in-placental-gene-expression-and-pregnancy-outcome
#7
Erica B Mahany, Xingfa Han, Beatriz C Borges, Sanseray da Silveira Cruz-Machado, Susan J Allen, David Garcia-Galiano, Mark J Hoenerhoff, Nicole H Bellefontaine, Carol F Elias
Obese women are at high risk of pregnancy complications, including preeclampsia, miscarriage, preterm birth, stillbirth and neonatal death. In the present study, we aimed to determine the effects of obesity on pregnancy outcome and placental gene expression in preclinical mouse models of genetic and nutritional obesity. The leptin receptor null reactivatable (LepRloxTB), the LepR deficient (Leprdb/+) and high fat diet (HFD) fed mice were assessed for fertility, pregnancy outcome, placental morphology and placental transcriptome using standard qPCR and qPCR arrays...
February 9, 2018: Endocrinology
https://www.readbyqxmd.com/read/29437902/maternal-resveratrol-consumption-and-its-programming-effects-on-metabolic-health-in-offspring-mechanisms-and-potential-implications
#8
Sheng Zheng, Qianyun Feng, Jing Cheng, Jia Zheng
A growing body of evidence has clearly demonstrated that maternal nutrition can strongly determine the susceptibility to the development of metabolic diseases in offspring. With the increasing prevalence of maternal overweight, obesity, and gestational diabetes mellitus, it yields enormous burden for individual and public health. Interventions during pregnancy have been proven to be challenging, with limited efficacy and low compliance. Resveratrol, as a natural polyphenolic compound, has a wide-range of beneficial properties, including potent anti-obesogenic, anti-atherosclerotic, and anti-diabetic effects...
February 5, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29433770/acid-folic-and-pregnancy-a-mandatory-supplementation
#9
Morgane Valentin, Perrine Coste Mazeau, Michel Zerah, Pierre François Ceccaldi, Alexandra Benachi, Dominique Luton
Neural tube defects (NTD) occur in 0.5 to 2 per 1000 pregnancies with various handicaps for the affected child. It is now well established that folic acid deficiency (absolute or relative) is a predisposing factor to this type of malformation. Several randomized controlled trials showed that high-dose folic acid (4mg) is an essential factor for prevention of neural tube defects recurrence and significantly prevents the first occurrence of neural tube defects with a lower dose (0.4mg). Other etiologies can favor the occurrence of NTD such as MTHFR polymorphism, some antiepileptic therapies, obesity and pregestational mellitus diabetes...
February 9, 2018: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29433747/clinical-social-and-genetic-factors-associated-with-obesity-at-12-months-of-age
#10
Sahel Hazrati, Wendy S W Wong, Kathi Huddleston, Yvonne Yui, Nancy Gilchrist, Benjamin D Solomon, John Niederhuber, Suchitra K Hourigan
OBJECTIVE: To examine genomic, social, and clinical risk factors of ≥85 weight for length percentile (WFLP) at 12 months. STUDY DESIGN: Children in this study had whole-genome sequencing, and clinical and social data were collected. WFLPs at 12 months of age were grouped as follows: (1) <85th, (2) ≥85th to <95th, (3) ≥95th to <99th, and (4) ≥99th. Whole-genome sequencing data were used to analyze rare and common variants, and association of clinical and social factors was examined...
February 9, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29427694/pregnancy-outcomes-in-women-with-an-early-diagnosis-of-gestational-diabetes-mellitus
#11
Maisa N Feghali, Kaleab Z Abebe, Diane M Comer, Steve Caritis, Janet M Catov, Christina M Scifres
AIM: To examine pregnancy outcomes in women with gestational diabetes mellitus (GDM) based on the timing of diagnosis. METHOD: We compared demographics, blood sugars and outcomes between women diagnosed before (n=167) or after 24 weeks' gestation (n=1202) in a single hospital between 2009 and 2012. Because early screening is risk-based we used propensity score modelling and conditional logistic regression to account for systematic differences. RESULTS: Women diagnosed with GDM before 24 weeks were more likely to be obese and they were less likely to have excess gestational weight gain (35 vs...
February 7, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29422214/evidence-based-national-guidelines-for-the-management-of-suspected-fetal-growth-restriction-comparison-consensus-and-controversy
#12
REVIEW
Lesley M McCowan, Francesc Figueras, Ngaire H Anderson
Small for gestational age is usually defined as an infant with a birthweight <10th centile for a population or customized standard. Fetal growth restriction refers to a fetus that has failed to reach its biological growth potential because of placental dysfunction. Small-for-gestational-age babies make up 28-45% of nonanomalous stillbirths, and have a higher chance of neurodevelopmental delay, childhood and adult obesity, and metabolic disease. The majority of small-for-gestational-age babies are not recognized before birth...
February 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29421859/review-shows-that-maternal-obesity-induces-serious-adverse-neonatal-effects-and-is-associated-with-childhood-obesity-in-their-offspring
#13
REVIEW
Delphine Mitanchez, Pascale Chavatte-Palmer
AIM: Obesity at the start of pregnancy has been rising worldwide, increasing the risk of maternal complications. We reviewed the independent effects of maternal obesity during pregnancy on neonatal adverse outcomes and the risk of childhood obesity and adverse cardio-metabolic profiles. METHODS: We searched MEDLINE for papers published in English between December 2007 and November 2017, focusing primarily on human studies published in the last five years. However, we also chose to highlight examples derived from model animals that could bring mechanistic insight and preventive and therapeutic avenues...
February 8, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29421405/pregnancy-urinary-bisphenol-a-concentrations-and-glucose-levels-across-bmi-categories
#14
Andrea Bellavia, David E Cantonwine, John D Meeker, Russ Hauser, Ellen W Seely, Thomas F McElrath, Tamarra James-Todd
BACKGROUND: Pregnancy exposure to bisphenol-A (BPA) may be associated with gestational diabetes (GDM), but evidence from human studies is limited. Moreover, adiposity is associated with both higher BPA concentrations and GDM risk, and may act as a confounder or an effect modifier of the association. METHODS: We included 350 term births from the Lifecodes pregnancy cohort (Boston, MA), who had 1st and 2nd trimester measures of urinary BPA concentrations available...
January 27, 2018: Environment International
https://www.readbyqxmd.com/read/29421161/therapies-for-gestational-diabetes-and-their-implications-for-maternal-and-offspring-health-evidence-from-human-and-animal-studies
#15
REVIEW
Gabriel M Brawerman, Vernon W Dolinsky
Obesity prior to and during pregnancy is associated with an increased risk of complications during pregnancy. One of the most common complications of pregnancy is gestational diabetes mellitus (GDM), a condition characterized by hyperglycemia and insulin resistance that is diagnosed in the third trimester of pregnancy. GDM predisposes both mothers and their children to increased obesity and cardiometabolic disorders, namely type 2 diabetes and cardiovascular disease. Current treatments include lifestyle changes and insulin injections, but oral anti-diabetic drugs such as metformin and glyburide are increasingly prescribed as they do not require injections...
February 5, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29420406/risk-of-adverse-pregnancy-outcomes-at-advanced-maternal-age
#16
Line Elmerdahl Frederiksen, Andreas Ernst, Nis Brix, Lea Lykke Braskhøj Lauridsen, Laura Roos, Cecilia Høst Ramlau-Hansen, Charlotte Kvist Ekelund
OBJECTIVE: To study the possible associations between advanced maternal age and risk of selected adverse pregnancy outcomes. METHODS: The study used a nationwide cohort of 369,516 singleton pregnancies in Denmark followed from 11-14 weeks of gestation to delivery or termination of pregnancy. Pregnant women aged 35 years or older were divided into two advanced maternal age groups, 35-39 years and 40 years or older, and compared with pregnant women aged 20-34 years...
February 5, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29419619/second-trimester-ultrasound-detection-of-fetal-anomalies-in-the-obese-obstetrical-population-a-systematic-review-protocol
#17
Christina Preen, Zachary Munn, Smita Raju, Nicholas Flack
The objective of this review is to identify, appraise and synthesize the best available evidence on the impact of maternal obesity on mid second trimester ultrasound detection of fetal anomalies in pregnancy.
February 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29419580/self-monitoring-lifestyle-behavior-in-overweight-and-obese-pregnant-women-qualitative-findings
#18
Carol Shieh, Claire Burke Draucker
BACKGROUND: Excessive maternal gestational weight gain increases pregnancy and infant complications. Self-monitoring has been shown to be an effective strategy in weight management. Literature, however, is limited in describing pregnant women's engagement in self-monitoring. AIM: This qualitative study explored the experiences of overweight and obese pregnant women who self-monitored their eating, walking, and weight as participants in an intervention for excessive gestational weight gain prevention...
March 2018: Clinical Nurse Specialist CNS
https://www.readbyqxmd.com/read/29417365/integrating-obstetrical-care-and-wic-nutritional-services-to-address-maternal-obesity-and-postpartum-weight-retention
#19
Susan M Gross, Marycatherine Augustyn, Janice L Henderson, Khrysta Baig, Christie A Williams, Bolanle Ajao, Patricia Bell-Waddy, David M Paige
OBJECTIVE: This pilot study evaluated a cost neutral, integrated Special Supplemental Nutrition Program for Women Infants and Children (WIC) and obstetrical service model designed to prevent postpartum weight retention in obese women. METHODS: A sample of women who received benefits from the Johns Hopkins (JH) WIC program and prenatal care from the JH Nutrition in Pregnancy Clinic, which provides obstetrical care for women with a BMI ≥ 30 kg/m2, participated in the WICNIP randomized clinical trial...
February 7, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29415594/maternal-obesity-is-not-associated-with-increased-crown-rump-length-in-first-trimester-ultrasounds-of-singleton-gestations
#20
Geoffrey H Gordon, Kathleen M Antony, Emmanuel Sampene, Jesus Igor Iruretagoyena
OBJECTIVE: To evaluate whether or not obesity affects fetal growth in the first trimester of pregnancy. STUDY DESIGN: A retrospective cohort study of obese versus nonobese women in our ultrasound database was performed to compare crown-rump length (CRL), a surrogate of fetal growth, at the first-trimester genetic screening. RESULTS: A total of 50 obese and 50 nonobese women were included. CRL for both groups was performed at an average of 12wk5d ± 3 d...
February 7, 2018: Journal of Maternal-fetal & Neonatal Medicine
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