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https://www.readbyqxmd.com/read/28624828/unique-imaging-features-enabling-the-prenatal-diagnosis-of-developmental-venous-anomalies-a-persistent-echogenic-brain-lesion-drained-by-a-collecting-vein-in-contrast-with-normal-brain-parenchyma-on-mri
#1
Karina Krajden Haratz, Alon Peled, Boris Weizman, Liat Gindes, Mordechai Tamarkin, Dorit Lev, Dvora Kidron, Liat Ben-Sira, Gustavo Malinger, Tally Lerman-Sagie, Zvi Leibovitz
OBJECTIVE: To describe the prenatal imaging features enabling diagnosis of developmental venous anomalies (DVA). METHODS: Four fetuses with unexplained persistent echogenic parenchymal brain lesions were studied. The evaluation included dedicated neurosonography, fetal MRI, serology for intrauterine infection, screening for coagulation abnormalities, and chromosomal microarray. Postnatal neurodevelopmental follow-up or autopsy results were assessed. RESULTS: DVA presented as very slowly growing echogenic brain lesions without cystic components, calcifications, or structural changes on otherwise normal neurosonographic scans performed at 2- to 3-week intervals...
June 17, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28621821/an-unusual-case-of-dental-infection-by-pseudomonas-aeruginosa-causing-a-brain-abscess-case-report
#2
Rodrigo Dos Santos Pereira, João Paulo Bonardi, Arthur da Conceição Dias Ferreira, Gustavo Lima Latini
A brain abscess may result when dental infection reaches the brain through contiguous anatomic cavities such as the maxillary sinus, the ethmoid sinus and the orbital cavity. It is an important complication and should be treated aggressively. Such treatment would include the excision of the etiological factor, drainage and adjuvant antibiotic therapy. The present case concerns a 23-year-old woman who presented at the General Hospital of Nova Iguaçu with complaints of pain in the right side of the face and was diagnosed with acute sinusitis...
June 16, 2017: Australian Dental Journal
https://www.readbyqxmd.com/read/28614970/effect-of-cerebrospinal-fluid-drainage-on-brain-tissue-oxygenation-in-traumatic-brain-injury
#3
Omar S Akbik, Mark Krasberg, Edwin M Nemoto, Howard Yonas
The effectiveness of cerebrospinal fluid (CSF) drainage in lowering high intracranial pressure (ICP) is well established in severe traumatic brain injury (TBI). However, recently the use of external ventricular drains and intracranial pressure monitors in traumatic brain injury has come under question. The aim of this retrospective study was to investigate the effect of CSF drainage on brain tissue oxygenation (PbtO2). Using a multimodality monitoring system, we continuously monitored brain tissue oxygenation (PbtO2) and parenchymal ICP during CSF drainage events via a ventriculostomy in 40 patients with severe traumatic brain injury (TBI)...
June 14, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28607341/thrombolysis-for-non-traumatic-intra-ventricular-hemorrhage-in-adults-a-critical-reappraisal
#4
Daniele Starnoni, Mauro Oddo, Rodolfo Maduri, Mahmoud Messerer, Roy T Daniel
Intra-ventricular hemorrhage (IVH) is a critical condition with high rate of morbidity and mortality due to acute hydrocephalus and secondary brain injury. Mechanisms underlining the clinical deterioration are not only related to the appearance of an acute hydrocephalus but also to blood- clot mass effect and the inflammatory effects of blood break-down products which impede local blood flow and exert a direct toxic effect on the peri-ventricular structures leading to chronic hydrocephalus. An effective treatment strategy should aim at IVH fast removal and reduction of blood-clot mass effect...
June 12, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28576261/-critical-analysis-of-reference-studies-on-aluminium-based-adjuvants-toxicokinetics
#5
REVIEW
J-D Masson, G Crépeaux, F-J Authier, C Exley, R K Gherardi
We reviewed the three reference toxicokinetic studies commonly used to suggest innocuity of aluminum (Al)-based adjuvants. A single experimental study was carried out using isotopic (26)Al (Flarend et al., 1997). This study ignored adjuvant cell capture. It was conducted over a short period of time (28 days) and used only two rabbits per adjuvant. At the endpoint, Al retention was 78% for aluminum phosphate and 94% for aluminum hydroxide, both results being incompatible with quick elimination of vaccine-derived Al in urines...
May 30, 2017: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/28573184/a-comparative-study-of-replication-incompetent-and-competent-adenoviral-therapy-mediated-immune-response-in-a-murine-glioma-model
#6
Julius W Kim, Jason Miska, Jacob S Young, Aida Rashidi, J Robert Kane, Wojciech K Panek, Deepak Kanojia, Yu Han, Irina V Balyasnikova, Maciej S Lesniak
Oncolytic virotherapy is a treatment approach with increasing clinical relevance, as indicated by the marked survival benefit seen in animal models and its current exploration in human patients with cancer. The use of an adenovirus vector for this therapeutic modality is common, has significant clinical benefit in animals, and its efficacy has recently been linked to an anti-tumor immune response that occurs following tumor antigen presentation. Here, we analyzed the adaptive immune system's response following viral infection by comparing replication-incompetent and replication-competent adenoviral vectors...
June 16, 2017: Molecular Therapy Oncolytics
https://www.readbyqxmd.com/read/28560123/use-of-subdural-evacuating-port-system-following-open-craniotomy-with-excision-of-native-dura-and-membranes-for-management-of-chronic-subdural-hematoma
#7
Tene Cage, Ashley Bach, Michael W McDermott
An 86-year-old woman was admitted to the intensive care unit with a chronic subdural hematoma (CSDH) and rapid onset of worsening neurological symptoms. She was taken to the operating room for a mini-craniotomy for evacuation of the CSDH including excision of the dura and CSDH membrane. Postoperatively, a subdural evacuation port system (SEPS) was integrated into the craniotomy site and left in place rather than a traditional subdural catheter drain to evacuate the subdural space postoperatively. The patient had a good recovery and improvement of symptoms after evacuation and remained clinically well after the SEPS was removed...
April 26, 2017: Curēus
https://www.readbyqxmd.com/read/28560029/is-there-a-doctor-in-the-house-availability-of-israeli-physicians-to-the-workforce
#8
Pamela Kuflik Horowitz, Annarosa Anat Shemesh, Tuvia Horev
BACKGROUND: Israeli policymakers have expressed serious concerns about being able to meet the growing demand for physician services. For this reason, the Israel Ministry of Health (MoH) undertook studies based on 2008 and then 2012 data to obtain an accurate assessment of the size, specialty mix, demographic and geographic composition of the physician workforce. This paper highlights the findings from these studies about the number and percentage of licensed physicians in Israel who were not available, were only partially available, or were about to leave the Israeli healthcare workforce...
2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28555269/placement-accuracy-of-external-ventricular-drain-when-comparing-freehand-insertion-to-neuronavigation-guidance-in-severe-traumatic-brain-injury
#9
Ahmed AlAzri, Kelvin Mok, Jeffrey Chankowsky, Mohammad Mullah, Judith Marcoux
BACKGROUND: External ventricular drain (EVD) placement is a frequently performed neurosurgical procedure. Inaccuracies in drain positioning and the need for multiple passes using the classic freehand insertion technique is well reported in the literature, especially in the traumatic brain injury (TBI) population. The purpose of this study was to evaluate if electromagnetic neuronavigation guidance for EVD insertion improves placement accuracy and minimizes the number of passes in severe TBI patients...
May 29, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28552157/surgical-management
#10
Michael K Morgan
Surgical management includes selection of patients for surgery, performing the technical procedure of brain arteriovenous malformation (bAVM) resection and perioperative management that maximize the chance for the best outcome. In general the Spetzler-Ponce class (SPC) can divide patients into those with good evidence that surgery is appropriate in most cases (SPC A), those in whom surgery should only be considered occasionally with highly nuanced indications (SPC C), and surgery may be appropriate having made a detailed analysis of patient (including age), clinical (including mode of presentation), and AVM characteristics (including diffuseness), and a comparative analysis of outcomes with alternate management pathways for SPC B cases...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28522487/countering-european-brain-drain
#11
Reinhilde Veugelers
No abstract text is available yet for this article.
May 19, 2017: Science
https://www.readbyqxmd.com/read/28516038/detection-of-fusobacterium-nucleatum-in-culture-negative-brain-abscess-by-broad-spectrum-bacterial-16s-rrna-gene-pcr
#12
Catherine Chakvetadze, Anastasia Purcarea, Aurelia Pitsch, Jonathan Chelly, Sylvain Diamantis
BACKGROUND: Fusobacterium nucleatum is a strict anaerobic microorganism commensal to the human oropharynx and gastrointestinal tract, which causes a wide spectrum of human diseases and it is an important pathogen in abscesses. CASE PRESENTATION: We report the case of a previously healthy 64-year-old woman with multiple abscesses due to Fusobacterium nucleatum, involving liver, pleura and brain. Fusobacterium was not recovered from blood cultures nor from culture of hepatic, pleural and brain drain fluid...
2017: IDCases
https://www.readbyqxmd.com/read/28494642/normal-anatomy-and-variations-in-the-confluence-of-sinuses-using-digital-subtraction-angiography
#13
Yaqin Cheng, William A Li, Xingjuan Fan, Xiaohua Li, Jian Chen, Yan Wu, Ran Meng, Xunming Ji
OBJECTIVES: The configuration of the confluence of sinuses differs not only between individuals, but also between the two brain hemispheres, making the anatomical classification of this region difficult. In this study, we evaluated the anatomy of the confluence of sinuses and ascertained the accuracy and usefulness of digital subtraction angiography (DSA) in the evaluation of cerebral veins. METHODS: Bilateral carotid and vertebral artery angiographies were performed in 500 adult patients to evaluate the anatomy of the confluence of sinuses and contributory venous sinuses...
June 2017: Neurological Research
https://www.readbyqxmd.com/read/28489610/invasive-and-noninvasive-means-of-measuring-intracranial-pressure-a-review
#14
Xuan Zhang, Joshua Medow, Bermans Iskandar, Fa Wang, Mehdi Shokoueinejad, Joyce Koueik, John Webster
Measurement of intracranial pressure (ICP) can be invaluable in the management of critically ill patients. Cerebrospinal fluid (CSF) is produced by the choroid plexus in the brain ventricles (a set of communicating chambers), after which it circulates through the different ventricles and exits into the subarachnoid space (SAS) around the brain, where it is reabsorbed into the venous system. If the fluid does not drain out of the brain or get reabsorbed, the ICP increases, which may lead to brain damage or death...
May 10, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28481768/orbital-perivenous-abscess-complicating-the-diagnosis-and-management-of-orbital-cellulitis
#15
Rohan Verma, Bradford W Lee, Ramzi M Alameddine, Audrey C Ko, Paritosh C Khanna, Don O Kikkawa, Bobby S Korn
An 11-year-old female presented with orbital cellulitis, bacterial sinusitis, enlarged left superior ophthalmic vein, dural venous sinuses, and internal jugular vein. The patient underwent endoscopic sinus surgery and was started on intravenous antibiotics and anticoagulation with limited improvement in orbital signs and symptoms. A magnetic resonance imaging/magnetic resonance venography of the orbits and brain revealed a dilated left superior ophthalmic vein with absence of flow but no clearly discernible orbital abscess...
May 5, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28480083/optic-nerve-sheath-diameter-as-a-bedside-assessment-for-elevated-intracranial-pressure
#16
Peter Williams
A previously fit and healthy 26-year-old lady with no significant medical history presented with a two-month history of headaches. The headaches were prolonged, generalised, and unusually severe for the patient. Examination revealed papilloedema. The patient's optic nerve sheath diameter was measured 3 mm posterior to the globe and found to be 7.5 mm. The patient subsequently had computed tomography scan of her brain that showed an optic nerve sheath diameter of 7.56 mm as measured 3 mm posterior to the globe...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/28479523/lesion-optimization-for-laser-ablation-fluid-evacuation-prior-to-laser-induced-thermal-therapy
#17
Timothy Wong, Nitesh V Patel, Filipe Feiteiro, Shabbar F Danish, Simon Hanft
BACKGROUND: Magnetic Resonance Guided Laser-Induced Thermal Therapy (MRgLITT) is a minimally invasive surgical procedure for ablating intracranial lesions. However, the presence of a fluid body can sequester thermal energy generated by the laser catheter.1-5 This compromises the performance of MRgLITT, and results in suboptimal ablation of cystic lesions. The authors report their surgical approach, namely stereotactic fluid aspiration followed by MRgLITT, on two patients with cystic brain tumors...
May 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28461277/drain-insertion-in-chronic-subdural-hematoma-an-international-survey-of-practice
#18
Jehuda Soleman, Maria Kamenova, Katharina Lutz, Raphael Guzman, Javier Fandino, Luigi Mariani
OBJECTIVE: The aim of this international survey was to investigate whether practice concerning drain insertion after burr hole drainage of cSDH following the publication of grade I evidence that it reduces recurrence rates has changed. Further, we aimed to document various practice modalities concerning the insertion of a drain adopted by neurosurgeons internationally. METHODS: We administered a survey to neurosurgeons all over the world with questions relating the surgical treatment of cSDH, emphasizing on their practices concerning the use of a drain...
April 28, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28443599/a-pott-s-puffy-tumor-associated-with-epidural-cutaneous-fistula-and-epidural-abscess-case-report
#19
Aleksandar Perić, Milanko Milojević, Dražen Ivetić
BACKGROUND: Pott's puffy tumour is characterized by a fluctuate swelling of the frontal region as a result of osteomyelitis of the frontal bone. This inflammatory lesion may propagate endocranially, resulting in acute meningitis, epidural abscess, subdural empyema, cavernous sinus trombophlebitis, cerebritis, and frontal lobe abscess of the brain. CASE REPORT: We present an unusual case of a 33-year-old man suffering from Pott's puffy tumour whose condition was further complicated by a draining epidural-cutaneous fistula and an epidural abscess...
May 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28439544/quantifying-the-negative-impact-of-brain-drain-on-the-integration-of-european-science
#20
Omar A Doria Arrieta, Fabio Pammolli, Alexander M Petersen
The 2004/2007 European Union (EU) enlargement by 12 member states offers a unique opportunity to quantify the impact of EU efforts to expand and integrate the scientific competitiveness of the European Research Area (ERA). We apply two causal estimation schemes to cross-border collaboration data extracted from millions of academic publications from 1996 to 2012, which are disaggregated across 14 subject areas and 32 European countries. Our results illustrate the unintended consequences following the 2004/2007 enlargement, namely, its negative impact on cross-border collaboration in science...
April 2017: Science Advances
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