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https://www.readbyqxmd.com/read/28437543/association-of-donor-age-and-sex-with-survival-of-patients-receiving-transfusions
#1
Gustaf Edgren, Henrik Ullum, Klaus Rostgaard, Christian Erikstrup, Ulrik Sartipy, Martin J Holzmann, Olof Nyrén, Henrik Hjalgrim
Importance: Following animal model data indicating the possible rejuvenating effects of blood from young donors, there have been at least 2 observational studies conducted with humans that have investigated whether donor age affects patient outcomes. Results, however, have been conflicting. Objective: To study the association of donor age and sex with survival of patients receiving transfusions. Design, Setting, and Participants: A retrospective cohort study based on the Scandinavian Donations and Transfusions database, with nationwide data, was conducted for all patients from Sweden and Denmark who received at least 1 red blood cell transfusion of autologous blood or blood from unknown donors between January 1, 2003, and December 31, 2012...
April 24, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28436425/monocyte-differentiation-and-antigen-presenting-functions
#2
REVIEW
Claudia V Jakubzick, Gwendalyn J Randolph, Peter M Henson
Monocytes develop in the bone marrow and represent the primary type of mononuclear phagocyte found in the blood. They were long thought of as a source for tissue macrophages, but recent studies indicate more complex roles for monocytes, both within the circulation and after their migration into tissues and lymphoid organs. In this Review, we discuss the newer concepts underlying the maturation of emigrating monocytes into different classes of tissue macrophages, as well as their potential functions, as monocyte-derived cells, in the tissues...
April 24, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28434672/women-s-attitudes-towards-the-medicalization-of-childbirth-and-their-associations-with-planned-and-actual-modes-of-birth
#3
Yael Benyamini, Maya Lila Molcho, Uzi Dan, Miri Gozlan, Heidi Preis
PROBLEM: Rates of medical interventions in childbirth have greatly increased in the Western world. BACKGROUND: Women's attitudes affect their birth choices. AIM: To assess women's attitudes towards the medicalization of childbirth and their associations with women's background as well as their fear of birth and planned and unplanned modes of birth. METHODS: This longitudinal observational study included 836 parous woman recruited at women's health centres and natural birth communities in Israel...
April 20, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28418479/associations-of-maternal-antidepressant-use-during-the-first-trimester-of-pregnancy-with-preterm-birth-small-for-gestational-age-autism-spectrum-disorder-and-attention-deficit-hyperactivity-disorder-in-offspring
#4
Ayesha C Sujan, Martin E Rickert, A Sara Öberg, Patrick D Quinn, Sonia Hernández-Díaz, Catarina Almqvist, Paul Lichtenstein, Henrik Larsson, Brian M D'Onofrio
Importance: Prenatal antidepressant exposure has been associated with adverse outcomes. Previous studies, however, may not have adequately accounted for confounding. Objective: To evaluate alternative hypotheses for associations between first-trimester antidepressant exposure and birth and neurodevelopmental problems. Design, Setting, and Participants: This retrospective cohort study included Swedish offspring born between 1996 and 2012 and followed up through 2013 or censored by death or emigration...
April 18, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28414672/a-strong-and-fortuitous-case-of-dyspnea
#5
R Hammer, M Sciaudone
CASE: A 48 year-old man with no past medical history was sent to our emergency department (ED); from a primary care clinic for hypertensive urgency of 200/130. The man reported an intermittent non-productive cough of approximately one year's duration and worsening dyspnea on exertion and orthopnea over the last month with lower extremity swelling. Of note, he emigrated from Honduras twenty years ago. Blood pressure normalized with administration of Lasix in the ED. Physical exam revealed rales in lung bases bilaterally, jugular venous distension, lower extremity pitting edema with serpiginous patches of erythema and excoriation, and a cardiac gallop...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28409861/neocolonialism-and-health-care-access-among-marshall-islanders-in-the-united-states
#6
Michael R Duke
In the Marshall Islands, a history of extensive nuclear weapons testing and covert biomedical research, coupled with the U.S.'s ongoing military presence in the country, has severely compromised the health of the local population. Despite the U.S.'s culpability in producing ill health along with high rates of emigration from the islands to the mainland United States, the large portion of Marshallese who reside in the United States face substantial barriers to accessing health care. Drawing from ongoing field research with a Marshallese community in Arkansas, this article explores the multifaceted impediments that U...
April 13, 2017: Medical Anthropology Quarterly
https://www.readbyqxmd.com/read/28400384/stroke-in-systemic-lupus-erythematosus-a-swedish-population-based-cohort-study
#7
Elizabeth V Arkema, Elisabet Svenungsson, Mia Von Euler, Christopher Sjöwall, Julia F Simard
OBJECTIVE: To study the occurrence of ischaemic and haemorrhagic stroke in systemic lupus erythematosus (SLE) compared with the general population by age, sex and time since SLE diagnosis METHODS: Adults with incident SLE were identified from the Swedish National Patient Register (NPR, n=3390) and general population comparators from the Total Population Register were matched on age, sex and county (n=16730). Individuals were followed prospectively until first of death, December 2013, emigration or incident stroke (identified from the NPR, Cause of Death Register and the Stroke Register)...
April 11, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28384711/association-between-deliberate-self-harm-and-violent-criminality
#8
Hanna Sahlin, Ralf Kuja-Halkola, Johan Bjureberg, Paul Lichtenstein, Yasmina Molero, Mina Rydell, Erik Hedman, Bo Runeson, Jussi Jokinen, Brjánn Ljótsson, Clara Hellner
Importance: Individuals who self-harm may have an increased risk of aggression toward others, but this association has been insufficiently investigated. More conclusive evidence may affect assessment, treatment interventions, and clinical guidelines. Objective: To investigate the association between nonfatal self-harm and violent crime. Design, Setting, and Participants: This population-based longitudinal cohort study, conducted from January 1, 1997, through December 31, 2013, studied all Swedish citizens born between 1982 and 1998 who were 15 years and older (N = 1 850 252)...
April 5, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28378849/prediagnostic-enterolactone-concentrations-and-mortality-among-danish-men-diagnosed-with-prostate-cancer
#9
A K Eriksen, C Kyrø, N Nørskov, A K Bolvig, J Christensen, A Tjønneland, K Overvad, R Landberg, A Olsen
BACKGROUND/OBJECTIVES: Evidence on the role of diet in relation to prostate cancer progression is sparse. Foods rich in lignans have shown beneficial effects on prostate cancer progression in both animal studies and small human intervention studies, including beneficial effects on prostate-specific antigen levels and tumour growth. The lignan metabolite, enterolactone, has further shown to slow prostate cancer cell growth in vitro. The aim was to investigate the association between prediagnostic enterolactone concentrations and mortality among men with prostate cancer...
April 5, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28378359/the-causes-of-dispersal-and-the-cost-of-carryover-effects-for-an-endangered-bird-in-a-dynamic-wetland-landscape
#10
Ellen P Robertson, Robert J Fletcher, James D Austin
1.The decision to disperse or remain philopatric between breeding seasons has important implications for both ecology and evolution, including the potential for carryover effects, where an individual's previous history affects their current performance. Carryover effects are increasingly documented although underlying mechanisms remain unclear. 2.Here we test for potential carryover effects and their mechanisms by uniting hypotheses for the causes and consequences of habitat selection and dispersal across space and time...
April 5, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28376822/internationally-educated-nurses-in-canada-predictors-of-workforce-integration
#11
Christine L Covell, Marie-Douce Primeau, Kelley Kilpatrick, Isabelle St-Pierre
BACKGROUND: Global trends in migration accompanied with recent changes to the immigrant selection process may have influenced the demographic and human capital characteristics of internationally educated nurses (IENs) in Canada and in turn the assistance required to facilitate their workforce integration. This study aimed to describe the demographic and human capital profile of IENs in Canada, to explore recent changes to the profile, and to identify predictors of IENs' workforce integration...
April 4, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28376097/geospatial-characteristics-of-measles-transmission-in-china-during-2005-2014
#12
Wan Yang, Liang Wen, Shen-Long Li, Kai Chen, Wen-Yi Zhang, Jeffrey Shaman
Measles is a highly contagious and severe disease. Despite mass vaccination, it remains a leading cause of death in children in developing regions, killing 114,900 globally in 2014. In 2006, China committed to eliminating measles by 2012; to this end, the country enhanced its mandatory vaccination programs and achieved vaccination rates reported above 95% by 2008. However, in spite of these efforts, during the last 3 years (2013-2015) China documented 27,695, 52,656, and 42,874 confirmed measles cases. How measles manages to spread in China-the world's largest population-in the mass vaccination era remains poorly understood...
April 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28369537/seasonal-patterns-of-stored-product-insects-at-a-rice-mill
#13
Tanja McKay, Amanda L White, Laura A Starkus, Frank H Arthur, James F Campbell
The temporal and spatial patterns in flight activity outside of a rice mill were evaluated for the lesser grain borer [Rhyzopertha dominica (F.)], warehouse beetle [Trogoderma variabile Ballion], cigarette beetle [Lasioderma serricorne (F.)], and Indian meal moth [Plodia interpunctella (Hüϋbner)] to determine critical times of year when the mill would be vulnerable to invasion. Insect activity was monitored using pheromone-baited glue traps (N = 99) from June 2008 to October 2010. Traps were placed along exterior walls of all major buildings and along the fence around the perimeter of the facility...
March 25, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28367734/early-life-characteristics-social-mobility-during-childhood-and-risk-of-stroke-in-later-life-findings-from-a-swedish-cohort
#14
Amy Heshmati, M Pia Chaparro, Anna Goodman, Ilona Koupil
AIMS: To investigate if early life characteristics and social mobility during childhood are associated with incident thrombotic stroke (TS), haemorrhagic stroke (HS) and other stroke (OS). METHODS: Our study population consists of all live births at Uppsala University Hospital in 1915-1929 (Uppsala Birth Cohort; n = 14,192), of whom 5532 males and 5061 females were singleton births and lived in Sweden in 1964. We followed them from 1 January 1964 until first diagnosis of stroke (in the National Patient Register or Causes of Death Register), emigration, death, or until 31 December 2008...
March 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28366199/favorable-ecological-circumstances-promote-life-expectancy-in-chimpanzees-similar-to-that-of-human-hunter-gatherers
#15
Brian M Wood, David P Watts, John C Mitani, Kevin E Langergraber
Demographic data on wild chimpanzees are crucial for understanding the evolution of chimpanzee and hominin life histories, but most data come from populations affected by disease outbreaks and anthropogenic disturbance. We present survivorship data from a relatively undisturbed and exceptionally large community of eastern chimpanzees (Pan troglodytes schweinfurthii) at Ngogo, Kibale National Park, Uganda. We monitored births, deaths, immigrations, and emigrations in the community between 1995 and 2016. Using known and estimated ages, we calculated survivorship curves for the whole community, for males and females separately, and for individuals ≤2 years old when identified...
April 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28365734/midas-2-0-an-ecosystem-specific-taxonomy-and-online-database-for-the-organisms-of-wastewater-treatment-systems-expanded-for-anaerobic-digester-groups
#16
Simon Jon McIlroy, Rasmus Hansen Kirkegaard, Bianca McIlroy, Marta Nierychlo, Jannie Munk Kristensen, Søren Michael Karst, Mads Albertsen, Per Halkjær Nielsen
Wastewater is increasingly viewed as a resource, with anaerobic digester technology being routinely implemented for biogas production. Characterising the microbial communities involved in wastewater treatment facilities and their anaerobic digesters is considered key to their optimal design and operation. Amplicon sequencing of the 16S rRNA gene allows high-throughput monitoring of these systems. The MiDAS field guide is a public resource providing amplicon sequencing protocols and an ecosystem-specific taxonomic database optimized for use with wastewater treatment facility samples...
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/28361127/longterm-maintenance-of-human-naive-t-cells-through-in-situ-homeostasis-in-lymphoid-tissue-sites
#17
Joseph J C Thome, Boris Grinshpun, Brahma V Kumar, Masa Kubota, Yoshiaki Ohmura, Harvey Lerner, Gregory D Sempowski, Yufeng Shen, Donna L Farber
Naïve T cells develop in the thymus and coordinate immune responses to new antigens; however, mechanisms for their long-term persistence over the human lifespan remain undefined. Here, we investigated human naïve T cell development and maintenance in primary and secondary lymphoid tissues obtained from individual organ donors aged 3 months-73 years. In the thymus, the frequency of double-positive thymocytes declined sharply in donors over age 40 coincident with reduced recent thymic emigrants (RTE) in lymphoid tissues, while naïve T cells were functionally maintained predominantly in lymph nodes (LN)...
December 2016: Science Immunology
https://www.readbyqxmd.com/read/28360389/potential-emigration-of-siberian-cattle-germplasm-on-chirikof-island-alaska
#18
M D Macneil, L J Alexander, J Kantanen, I A Ammosov, Z I Ivanova, R G Popov, M Ozerov, A Millbrooke, M A Cronin
Feral cattle residing in Chirikof Island, Alaska, are relatively distinct from breeds used in commercial production in North America. However, preliminary evidence suggested that they exhibit substantial genetic relationship with cattle from Yakutian region of Siberia. Thus, our objective was to further elucidate quantify the origins, admixture and divergence of the Chirikof Island cattle relative to cattle from Siberia and USA. Subject animals were genotyped at 15 microsatellite loci. Compared with Turano-Mongolian and North American cattle, Chirikof Island cattle had similar variation, with slightly less observed heterozygosity, fewer alleles per locus and a positive fixation index...
March 2017: Journal of Genetics
https://www.readbyqxmd.com/read/28359313/an-examination-of-the-causes-consequences-and-policy-responses-to-the-migration-of-highly-trained-health-personnel-from-the-philippines-the-high-cost-of-living-leaving-a-mixed-method-study
#19
Erlinda Castro-Palaganas, Denise L Spitzer, Maria Midea M Kabamalan, Marian C Sanchez, Ruel Caricativo, Vivien Runnels, Ronald Labonté, Gail Tomblin Murphy, Ivy Lynn Bourgeault
BACKGROUND: Dramatic increases in the migration of human resources for health (HRH) from developing countries like the Philippines can have consequences on the sustainability of health systems. In this paper, we trace the outflows of HRH from the Philippines, map out its key causes and consequences, and identify relevant policy responses. METHODS: This mixed method study employed a decentered, comparative approach that involved three phases: (a) a scoping review on health workers' migration of relevant policy documents and academic literature on health workers' migration from the Philippines; and primary data collection with (b) 37 key stakeholders and (c) household surveys with seven doctors, 329 nurses, 66 midwives, and 18 physical therapists...
March 31, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28356517/protectin-d1n-3-dpa-and-resolvin-d5n-3-dpa-are-effectors-of-intestinal-protection
#20
Thomas Gobbetti, Jesmond Dalli, Romain A Colas, Donata Federici Canova, Marius Aursnes, Delphine Bonnet, Laurent Alric, Nathalie Vergnolle, Celine Deraison, Trond V Hansen, Charles N Serhan, Mauro Perretti
The resolution of inflammation is an active process orchestrated by specialized proresolving lipid mediators (SPM) that limit the host response within the affected tissue; failure of effective resolution may lead to tissue injury. Because persistence of inflammatory signals is a main feature of chronic inflammatory conditions, including inflammatory bowel diseases (IBDs), herein we investigate expression and functions of SPM in intestinal inflammation. Targeted liquid chromatography-tandem mass spectrometry-based metabololipidomics was used to identify SPMs from n-3 polyunsaturated fatty acids in human IBD colon biopsies, quantifying a significant up-regulation of the resolvin and protectin pathway compared with normal gut tissue...
April 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
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