Jeane de Souza Nogueira, Thamires Rodrigues Gomes, Danielle Angst Secco, Inez Silva de Almeida, Alessandra Saldanha Matheus Fernandes da Costa, Roberta Arnoldi Cobas, Gilson Costados Santos, Marília Brito Gomes, Luís Cristóvão Pôrto
To control immune responses, regulatory CD4+ CD25+ Foxp3+ T cells (Treg) maintain their wide and diverse repertoire through continuous arrival of recent thymic emigrants (RTE). However, during puberty, the activity of RTE starts to decline as a natural process of thymic involution, introducing consequences, not completely described, to the repertoire. Type 1 diabetes (T1D) patients show quantitative and qualitative impairments on the Treg cells. Our aim was to evaluate peripheral Treg and RTE cell frequencies, in T1D patients from two distinct age groups (young and adults) and verify if HLA phenotypes are concomitant associated...
April 9, 2024: Immunology Letters