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https://www.readbyqxmd.com/read/28544284/the-national-healthcare-system-claims-databases-in-france-sniiram-and-egb-powerful-tools-for-pharmacoepidemiology
#1
Julien Bezin, Mai Duong, Régis Lassalle, Cécile Droz, Antoine Pariente, Patrick Blin, Nicholas Moore
The French health care system is based on universal coverage by one of several health care insurance plans. The SNIIRAM database merges anonymous information of reimbursed claims from all these plans, linked to the national hospital-discharge summaries database system (PMSI) and the national death registry. It now covers 98.8% of the French population, over 66 million persons, from birth (or immigration) to death (or emigration), making it possibly the world's largest continuous homogeneous claims database...
May 24, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28543274/diel-and-seasonal-movements-of-silver-eels-anguilla-dieffenbachii-emigrating-from-a-lake-subject-to-hydro-electric-control
#2
D J Jellyman, M J Unwin
To investigate the behaviour and fate of silver female longfin eels Anguilla dieffenbachii in relation to flow variations from New Zealand's largest (700 MW) hydro-electric station, 210 A. dieffenbachii were tagged with acoustic transmitters during summer and autumn over 6 years from 2005 to 2010. A shoreline array of receivers (2005-2008) was supplemented by positioning systems near the power station and natural outlet (2009-2010) that enabled continuous tracking of A. dieffenbachii within these areas...
May 22, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28542701/two-separate-effects-contribute-to-regulatory-t-cell-defect-in-sle-patients-and-their-unaffected-relatives
#3
Nuno Costa, Oriana Marques, Sandra I Godinho, Cláudia Carvalho, Barbara Leal, Ana M Figueiredo, Carlos Vasconcelos, António Marinho, Maria F Moraes-Fontes, António Gomes da Costa, Cristina Ponte, Raquel Campanilho-Marques, Telma Cóias, Ana R Martins, João F Viana, Margarida Lima, Berta Martins, Constantin Fesel
FOXP3(+) regulatory T-cells (Tregs) are functionally deficient in Systemic Lupus Erythematosus (SLE), characterized by reduced surface CD25 (the IL-2 receptor alpha chain). Low-dose IL-2 therapy is a promising current approach to correct this defect. To elucidate the origins of the SLE Treg phenotype, we studied its role through developmentally defined Treg subsets in 45 SLE patients, 103 SLE-unaffected first-degree relatives and 61 unrelated healthy control subjects, and genetic association with the CD25-encoding IL2RA locus...
May 24, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28532344/pre-transplantation-thymic-function-is-associated-with-the-risk-of-acute-graft-versus-host-disease-and-cytomegalovirus-viremia-after-allogeneic-hematopoietic-stem-cell-transplantation
#4
Xin Yang, Yuanxin Sun, Sudong Zhang, Hui Yang, Jialin Wei, Yi He, Donglin Yang, Erlie Jiang, Mingzhe Han, Xuemei Qin, Sizhou Feng
OBJECTIVES: To analyze the kinetics of T-cell subsets and thymic function reconstitution after allogeneic hematopoietic stem cell transplantation (AHSCT); to determine whether sjTREC (signal joint TCR rearrangement excision circle) and CD31-positive recent thymic emigrant (CD31 + RTE) are correlated with acute graft versus host disease (aGVHD) or CMV (cytomegalovirus) viremia after AHSCT. METHODS: Forty-nine patients who underwent AHSCT in our institution were prospectively enrolled...
May 22, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28530714/cd8%C3%AE-%C3%AE-intraepithelial-lymphocytes-arise-from-two-main-thymic-precursors
#5
Roland Ruscher, Rebecca L Kummer, You Jeong Lee, Stephen C Jameson, Kristin A Hogquist
TCRαβ(+)CD4(-)CD8α(+)CD8β(-) intestinal intraepithelial lymphocytes (CD8αα IELs) are an abundant population of thymus-derived T cells that protect the gut barrier surface. We sought to better define the thymic IEL precursor (IELp) through analysis of its maturation, localization and emigration. We defined two precursor populations among TCRβ(+)CD4(-)CD8(-) thymocytes by dependence on the kinase TAK1 and rigorous lineage-exclusion criteria. Those IELp populations included a nascent PD-1(+) population and a T-bet(+) population that accumulated with age...
May 22, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28529152/coevolution-of-patch-type-dependent-emigration-and-patch-type-dependent-immigration
#6
Helene C Weigang
The three phases of dispersal - emigration, transfer and immigration - are affecting each other and the former and latter decisions may depend on patch types. Despite the inevitable fact of the complexity of the dispersal process, patch-type dependencies of dispersal decisions modelled as emigration and immigration are usually missing in theoretical dispersal models. Here, I investigate the coevolution of patch-type dependent emigration and patch-type dependent immigration in an extended Hamilton-May model...
May 18, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28526953/mutual-interference-between-adult-females-of-galendromus-flumenis-acari-phytoseiidae-feeding-on-eggs-of-banks-grass-mite-decreases-predation-efficiency-and-increases-emigration-rate
#7
Fatemeh Ganjisaffar, Gösta Nachman, Thomas M Perring
The Banks grass mite, Oligonychus pratensis (Banks) (Acari: Tetranychidae) causes significant damage to dates in California (USA), if not controlled. Studies are underway to develop biological control strategies against this pest in dates using the predatory mite Galendromus flumenis (Chant) (Acari: Phytoseiidae). In California date gardens, this predator is found in low numbers that are insufficient for the economic suppression of Banks grass mites, and our research aims to understand why it fails to keep up with prey densities...
May 19, 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/28521824/are-ankylosing-spondylitis-psoriatic-arthritis-and-undifferentiated-spondyloarthritis-associated-with-an-increased-risk-of-cardiovascular-events-a-prospective-nationwide-population-based-cohort-study
#8
Karin Bengtsson, Helena Forsblad-d'Elia, Elisabeth Lie, Eva Klingberg, Mats Dehlin, Sofia Exarchou, Ulf Lindström, Johan Askling, Lennart T H Jacobsson
BACKGROUND: To investigate the risk of first-time acute coronary syndrome (ACS), stroke and venous thromboembolism (VTE) in patients with ankylosing spondylitis (AS), psoriatic arthritis (PsA) and undifferentiated spondyloarthritis (uSpA), compared to each other and to the general population (GP). METHODS: This is a prospective nationwide cohort study. Cohorts with AS (n = 6448), PsA (n = 16,063) and uSpA (n = 5190) patients and a GP (n = 266,435) cohort, were identified 2001-2009 in the Swedish National Patient and Population registers...
May 18, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28521622/exodus-from-hunger-the-long-term-health-consequences-of-the-1959-1961-chinese-famine
#9
Zhuoni Zhang, Shige Song, Xiaogang Wu
This article examines the long-term health consequences of China's 1959-1961 famine by comparing people who stayed in Guangdong and endured the famine with people who crossed the border to immigrate to Hong Kong and thus escaped the famine. Based on data from the Hong Kong Panel Study of Social Dynamics (HKPSSD) and the China Family Panel Studies (CFPS), we focused on two health indicators-body mass index (BMI) and self-rated health (SRH)-of the cohort born before 1959. Our results show that the stayers who experienced the famine have a lower BMI than the emigrants, and they are likely to have a poor SRH...
2017: Biodemography and Social Biology
https://www.readbyqxmd.com/read/28518216/queen-presence-mediates-the-relationship-between-collective-behavior-and-disease-susceptibility-in-ant-colonies
#10
Carl N Keiser, Svjetlana Vojvodic, Imani O Butler, Elizabeth Sartain, Volker H W Rudolf, Julia B Saltz
The success of social living can be explained, in part, by a group's ability to execute collective behaviors unachievable by solitary individuals. However, groups vary in their ability to execute these complex behaviors, often because they vary in their phenotypic composition. Group membership changes over time due to mortality or emigration, potentially leaving groups vulnerable to ecological challenges in times of flux. In some societies, the loss of important individuals (e.g., leaders, elites, queens) may have an especially detrimental effect on groups' ability to deal with these challenges...
May 18, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28507145/in-vivo-photolabeling-of-tumor-infiltrating-cells-reveals-highly-regulated-egress-of-t-cell-subsets-from-tumors
#11
Tommaso Torcellan, Henry R Hampton, Jacqueline Bailey, Michio Tomura, Robert Brink, Tatyana Chtanova
Immune therapy is rapidly gaining prominence in the clinic as a major weapon against cancer. Whereas much attention has been focused on the infiltration of tumors by immune cells, the subsequent fate of these infiltrates remains largely unexplored. We therefore established a photoconversion-based model that allowed us to label tumor-infiltrating immune cells and follow their migration. Using this system, we identified a population of tumor-experienced cells that emigrate from primary tumors to draining lymph nodes via afferent lymphatic vessels...
May 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28507025/cutting-edge-defective-aerobic-glycolysis-defines-the-distinct-effector-function-in-antigen-activated-cd8-recent-thymic-emigrants
#12
Cody A Cunningham, Tessa Bergsbaken, Pamela J Fink
Recent thymic emigrants (RTEs) are the youngest peripheral T cells that have completed thymic selection and egress to the lymphoid periphery. RTEs are functionally distinct from their more mature but still naive T cell counterparts, because they exhibit dampened proliferation and reduced cytokine production upon activation. In this article, we show that, compared with more mature but still naive T cells, RTEs are impaired in their ability to perform aerobic glycolysis following activation. Impaired metabolism underlies the reduced IFN-γ production observed in activated RTEs...
May 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28474787/cadherin-interplay-during-neural-crest-segregation-from-the-non-neural-ectoderm-and-neural-tube-in-the-early-chick-embryo
#13
Alwyn Dady, Jean-Loup Duband
BACKGROUND: In the avian embryo, neural crest (NC) progenitors arise in the neuroectoderm during gastrulation, long before their dissemination. Although the gene regulatory network involved in NC specification has been deciphered, the mechanisms involved in their segregation from the other neuroectoderm-derived progenitors, notably the epidermis and neural tube, are unknown. Because cadherins mediate cell recognition and sorting, we scrutinized their expression profiles during NC specification and delamination...
May 5, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28469238/associations-between-prediagnostic-blood-glucose-levels-diabetes-and-glioma
#14
Judith Schwartzbaum, Michael Edlinger, Victoria Zigmont, Pär Stattin, Grzegorz A Rempala, Gabriele Nagel, Niklas Hammar, Hanno Ulmer, Bernhard Föger, Göran Walldius, Jonas Manjer, Håkan Malmström, Maria Feychting
Previous literature indicates that pre-diagnostic diabetes and blood glucose levels are inversely related to glioma risk. To replicate these findings and determine whether they could be attributed to excess glucose consumption by the preclinical tumour, we used data from the Apolipoprotein MOrtality RISk (AMORIS) (n = 528,580) and the Metabolic syndrome and Cancer project (Me-Can) cohorts (n = 269,365). We identified individuals who were followed for a maximum of 15 years after their first blood glucose test until glioma diagnosis, death, emigration or the end of follow-up...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28464240/body-growth-and-life-history-in-wild-mountain-gorillas-gorilla-beringei-beringei-from-volcanoes-national-park-rwanda
#15
Jordi Galbany, Didier Abavandimwe, Meagan Vakiener, Winnie Eckardt, Antoine Mudakikwa, Felix Ndagijimana, Tara S Stoinski, Shannon C McFarlin
OBJECTIVES: Great apes show considerable diversity in socioecology and life history, but knowledge of their physical growth in natural settings is scarce. We characterized linear body size growth in wild mountain gorillas from Volcanoes National Park, Rwanda, a population distinguished by its extreme folivory and accelerated life histories. METHODS: In 131 individuals (0.09-35.26 years), we used non-invasive parallel laser photogrammetry to measure body length, back width, arm length and two head dimensions...
May 2, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28457909/critical-role-for-skin-derived-migratory-dcs-and-langerhans-cells-in-tfh-and-gc-responses-after-intradermal-immunization
#16
Clément Levin, Olivia Bonduelle, Charles Nuttens, Charlotte Primard, Bernard Verrier, Alexandre Boissonnas, Béhazine Combadière
Intradermal (ID) delivery of antigen represents a potent route of immunization that involves multiple blood- and skin-derived dendritic cell (DC) sub-populations endowed with specialized functions and dynamics in their ability to prime naïve CD4+ T cells in the draining lymph node (DLN). Yet, their individual contributions to the generation of CD4+ T follicular helper (TFH) cells and germinal centers (GCs) remain to be understood. We found that ID immunization of mice with a particle-based vaccine induced robust TFH and GC B cell responses in skin DLNs, which were completely abrogated when skin cell emigration was prevented...
April 27, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28456873/hospitalization-among-patients-with-sarcoidosis-a-population-based-cohort-study-1987-2015
#17
Patompong Ungprasert, Cynthia S Crowson, Sara J Achenbach, Eva M Carmona, Eric L Matteson
PURPOSE: There is little information about healthcare utilization for sarcoidosis. This study examined need for hospitalization as a measure of healthcare burden in this disease. METHODS: A cohort of Olmsted County, Minnesota residents diagnosed with sarcoidosis between January 1, 1976 and December 31, 2013 was identified using the resources of the Rochester Epidemiology Project. Diagnosis was made based on individual medical record review. For each sarcoidosis subject, one sex- and age-matched comparator without sarcoidosis was randomly selected from the same population...
April 29, 2017: Lung
https://www.readbyqxmd.com/read/28452652/health-equity-and-migrants-in-the-greater-mekong-subregion
#18
Celia McMichael, Judith Healy
BACKGROUND: Migrant health is receiving increasing international attention, reflecting recognition of the health inequities experienced among many migrant populations and the need for health systems to adapt to diverse migrant populations. In the Greater Mekong Subregion (GMS) there is increasing migration associated with uneven economic integration and growth, socio-economic vulnerabilities, and disparities between countries. There has been limited progress, however, in improving migrant access to health services in the Subregion...
2017: Global Health Action
https://www.readbyqxmd.com/read/28446653/vagotomy-and-parkinson-disease-a-swedish-register-based-matched-cohort-study
#19
Bojing Liu, Fang Fang, Nancy L Pedersen, Annika Tillander, Jonas F Ludvigsson, Anders Ekbom, Per Svenningsson, Honglei Chen, Karin Wirdefeldt
OBJECTIVE: To examine whether vagotomy decreases the risk of Parkinson disease (PD). METHODS: Using data from nationwide Swedish registers, we conducted a matched-cohort study of 9,430 vagotomized patients (3,445 truncal and 5,978 selective) identified between 1970 and 2010 and 377,200 reference individuals from the general population individually matched to vagotomized patients by sex and year of birth with a 40:1 ratio. Participants were followed up from the date of vagotomy until PD diagnosis, death, emigration out of Sweden, or December 31, 2010, whichever occurred first...
April 26, 2017: Neurology
https://www.readbyqxmd.com/read/28438899/galectin-3-a-positive-regulator-of-leukocyte-recruitment-in-the-inflamed-microcirculation
#20
Beatrice R Gittens, Jennifer V Bodkin, Sussan Nourshargh, Mauro Perretti, Dianne Cooper
In vivo and ex vivo imaging were used to investigate the function of galectin-3 (Gal-3) during the process of leukocyte recruitment to the inflamed microcirculation. The cremasteric microcirculation of wild-type (C57BL/6), Gal-3(-/-), and CX3CR1(gfp/+) mice were assessed by intravital microscopy after PBS, IL-1β, TNF-α, or recombinant Gal-3 treatment. These cellular responses were investigated further using flow-chamber assays, confocal microscopy, flow cytometry, PCR analysis, and proteome array. We show that mechanisms mediating leukocyte slow rolling and emigration are impaired in Gal-3(-/-) mice, which could be because of impaired expression of cell adhesion molecules and an altered cell surface glycoproteome...
June 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
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