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hepatocellular carcinoma

Jiahuan Zou, Mengwei Zhuang, Xiaopeng Yu, Na Li, Rudi Mao, Zhida Wang, Jianing Wang, Xiaoyan Wang, Huaiyu Zhou, Lining Zhang, Yongyu Shi
The effectiveness of immunotherapy targeting the immune checkpoint PD-L1/PD-1 pathway highlights importance of elucidating the regulatory mechanisms of PD-L1 expression in cancer cells. Previous studies demonstrate that oncogene MYC up-regulates PD-L1 expression in lymphomas. In the present study, we investigated the regulatory role of MYC in the PD-L1 expression induced by IFN-γ in HCC cells. Unexpectedly, knockdown of MYC expression using siRNA assay increased the inducible expression of PD-L1 both at mRNA and protein levels...
July 5, 2018: Molecular Immunology
Jie-Tao Chen, Xiao-Min Guo, Ping Yang, Qing Mu
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. The discovery of new anticancer compounds is of great significance. GG-8-6, cyclo-(Val1 -Leu2 -Pro3 -Ile4 -Leu5 -Leu6 -Leu7 -Val8 -Leu9 ), a new synthetic cyclic peptide, might be a potential candidate for developing new anti-HCC drugs. GG-8-6 shares no structural homology to current anti-HCC drugs. Therefore, it was necessary to develop a quantitative method for the determination of GG-8-6 in vivo. Herein, a simple, specific and sensitive liquid chromatographic method with tandem mass spectrometric detection (LC-MS/MS) was developed and validated for the analysis of GG-8-6 in rat plasma...
June 30, 2018: Journal of Pharmaceutical and Biomedical Analysis
Toshihide Shima, Hirofumi Uto, Kohjiro Ueki, Yutaka Kohgo, Kohichiroh Yasui, Naoto Nakamura, Tatsuaki Nakatou, Toshinari Takamura, Sumio Kawata, Kazuo Notsumata, Kyoko Sakai, Ryosuke Tateishi, Takeshi Okanoue
BACKGROUND: We reported a cross-sectional study on causes of liver injury in Japanese type 2 diabetes mellitus (T2D) patients (JG 2013). We assessed overall and cause-specific mortality risk during follow-up of patients enrolled in JG 2013. METHODS: This was a longitudinal, multicenter cohort study. Of the 5642 Japanese T2D patients who visited T2D clinics of nine hospitals in the original study, 3,999 patients were followed up for an average of 4.5 years. Expected deaths in T2D patients were estimated using age-specific mortality rates in the general population (GP) of Japan...
July 13, 2018: Journal of Gastroenterology
Yi Han, Yubo Liu, Xirao Fu, Qi Zhang, Huang Huang, Cheng Zhang, Wenli Li, Jianing Zhang
Glycosylation of cell surface proteins regulates critical cellular functions, including invasion and metastasis in cancer cells. Emerging evidence has shown that microRNAs (miRNAs) are involved in regulating both the glycosylation modifications on cell surface and the progression of cancer. In this study, we investigated the role of miR-9 in α-2,6-linked sialylation and the metastasis of mouse hepatocellular carcinoma (HCC). According to array-based miRNA expression profiling data of HCC cell lines Hepa1-6, Hca-P, and Hca-F with different lymphatic metastatic capacities, reverse correlation was found between miR-9 expression levels and the metastatic potential in these HCC cells...
July 13, 2018: Journal of Physiology and Biochemistry
Miok Kim, Seon-Jin Lee, Sangsu Shin, Kang-Seo Park, Sang Yoon Park, Chang Hoon Lee
Despite advances in the clinical management of hepatocellular carcinoma (HCC), this form of cancer remains the second leading cause of cancer-related death worldwide. Currently, there are few treatment options for advanced HCC. Therefore, novel treatment strategies for HCC are required. Here, we described the promising antitumour effects of anisomycin, which exerts both direct killing effects and natural killer cell (NK)-mediated immunotherapeutic effects in HCC. To better elucidate the mechanisms through which anisomycin mediates its antitumour effects, we performed a genome-scale transcriptional analysis...
July 13, 2018: Scientific Reports
Ariel D Quiroga, Richard Lehner
Excessive triacylglycerol (TG) accumulation is the distinctive feature of obesity. In the liver, sustained TG accretion leads to nonalcoholic fatty liver disease (NAFLD), eventually progressing to non-alcoholic steatohepatitis (NASH) and cirrhosis, which is associated with complications including hepatic failure, hepatocellular carcinoma and death. Pharmacological interventions are actively pursued to prevent lipid accumulation in hepatocytes and, therefore, to ameliorate the associated pathophysiological conditions...
July 10, 2018: Biochemical Pharmacology
Rae Jean Proeschold-Bell, Donna M Evon, Christina Makarushka, John B Wong, Santanu K Datta, Jia Yao, Ashwin A Patkar, Paolo Mannelli, Terra Hodge, Susanna Naggie, Julius M Wilder, Michael W Fried, Donna Niedzwiecki, Andrew J Muir
INTRODUCTION: Among patients with hepatitis C virus (HCV) infection, alcohol synergistically increases the risk of cirrhosis, hepatocellular carcinoma, and death. Randomized controlled trials of integrated models of HCV-alcohol treatment have been recommended but only performed in patients with severe alcohol use disorders. OBJECTIVES: This pragmatic randomized controlled trial seeks to compare clinical effectiveness and cost-effectiveness of integrated alcohol treatment compared to enhanced treatment as usual (TAU) on alcohol consumption and economic outcomes among patients ever infected with HCV...
July 10, 2018: Contemporary Clinical Trials
Zhize Chen, Jingjing Xu, Yang Wu, Shaoqing Lei, Huimin Liu, Qingtao Meng, Zhongyuan Xia
Emerging evidence has supported that TAZ (transcriptional co-activator with PDZ binding motif), one transcription co-activator in Hippo signaling pathway, plays an oncogenic role in liver carcinogenesis. Targeting TAZ could be a potential therapeutic approach for liver cancer patients. In the current study, we aim to determine whether diosgenin could be an inhibitor of TAZ in liver cancer cells. We found that diosgenin inhibited the expression of TAZ in liver cancer cells. Moreover, we found that diosgenin inhibited cell growth, induced apoptosis, suppressed cell migration and invasion in part via inhibition of TAZ in liver cancer cells...
July 11, 2018: Biochemical and Biophysical Research Communications
Tilman Kühn, Tobias Nonnenmacher, Disorn Sookthai, Ruth Schübel, Daniel Antonio Quintana Pacheco, Oyunbileg von Stackelberg, Mirja E Graf, Theron Johnson, Christopher L Schlett, Romy Kirsten, Cornelia M Ulrich, Rudolf Kaaks, Hans-Ulrich Kauczor, Johanna Nattenmüller
BACKROUND: Non-alcoholic fatty liver disease (NAFLD) comprises non-progressive steatosis and non-alcoholic steatohepatitis (NASH), the latter of which may cause cirrhosis and hepatocellular carcinoma (HCC). As NAFLD detection is imperative for the prevention of its complications, we evaluated whether a combination of blood-based biomarkers and anthropometric parameters can be used to predict NAFLD among overweight and obese adults. METHODS: 143 overweight or obese non-smokers free of diabetes (50% women, age: 35-65 years) were recruited...
July 13, 2018: BMC Gastroenterology
Yasuyuki Tamai, Motoh Iwasa, Yuya Kawasaki, Naohiko Yoshizawa, Suguru Ogura, Ryosuke Sugimoto, Akiko Eguchi, Norihiko Yamamoto, Kazushi Sugimoto, Hiroshi Hasegawa, Yoshiyuki Takei
AIM: Hepatocellular carcinoma (HCC) patients with sarcopenia have a poor survival, but there are no predictive markers for survival relating to muscle mass and liver function. Therefore, we investigated whether the ratio between estimated glomerular filtration rates of serum creatinine (Scre) and serum cystain C (Scys) (eGFRcre/eGFRcys) can be used as a predictive marker of survival in HCC patients. METHODS: First, the correlation between Scre/Scys ratio and muscle mass was examined in 50 patients with chronic liver disease...
July 13, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
Azam Raoofi, Effat Hatefnia, Anoshirvan Kazemnejad
Hepatitis B (HB) is one of the major public health problems and a major cause of liver cirrhosis and hepatocellular carcinoma (HCC). The aim of this study was to evaluate the effect of a model-based educational intervention on preventive health behavior of hepatitis B vaccination among women who were going to get married (pending marriage women). Seventy pending marriage women were selected from martial counseling centers. The participants' knowledge, health beliefs model (HBM) constructs, and intention to receive HB vaccination were collected using a questionnaire based on HBM...
July 13, 2018: Social Work in Public Health
Xuejie Min, Jun Wen, Li Zhao, Kaiying Wang, Qingli Li, Gang Huang, Jianjun Liu, Xiaoping Zhao
Although identified as a growth factor, the mechanism by which hepatoma-derived growth factor (HDGF) promotes cancer development remains unclear. We found that nuclear but not cytoplasmic HDGF is closely associated with prognosis of hepatocellular carcinoma (HCC). RNA-sequencing analysis further demonstrated that the nuclear role of HDGF involved regulation of transcription of lipid metabolism genes. HDGF-induced expression of lipogenic genes was mainly associated with activation of sterol regulatory element binding protein (SREBP) transcription factor...
July 13, 2018: Molecular Oncology
Fufang Liu, Chuan Li, Jia Zhu, Linan Ren, Xingshun Qi
BACKGROUND AND AIM: ABO blood type is an invariant factor. There is a link between ABO blood type and some malignancies, such as gastric, pancreatic, and skin cancer. The role of ABO blood type in the pathogenesis of hepatocellular carcinoma (HCC) remains controversial. We performed a meta-analysis to explore the relationship between ABO blood type and risk of HCC. METHODS: Literature search was conducted among the PubMed, EMBASE, and Cochrane Library databases...
July 13, 2018: Expert Review of Gastroenterology & Hepatology
Rakesh Kumar Gupta, Puja Sakhuja, Kaushik Majumdar, Shahajad Ali, Siddharth Srivastava, Sanjeev Sachdeva, Barjesh C Sharma, Amarender S Puri
Background and Aims: Liver biopsy may be considered in patients with hepatitis C virus (HCV) infection to assess the severity of liver injury and stage of fibrosis, thereby guiding therapeutic decisions. In addition, advanced stage also necessitates surveillance for hepatocellular carcinoma. The aim of this study was to assess whether transaminase (alanine transaminase [ALT]) levels and RNA titers correlate with the histological activity index (HAI) and fibrosis (F) stage in asymptomatic patients with incidentally detected HCV (IDHCV)...
July 2018: Indian Journal of Pathology & Microbiology
Noha Mohamed Hosni Shaheen, Naglaa Zayed, Nermine Magdi Riad, Hend H Tamim, Rasha Mohamed Hosny Shahin, Dalia A Labib, Suzan Mahrous ELsheikh, Reham Abdel Moneim, Ayman Yosry, Rania H Khalifa
In Egypt, liver diseases are exceptionally high, maintaining the highest prevalence of hepatitis C virus (HCV) worldwide, and increasing rates of hepatocellular carcinoma (HCC). Available diagnostic methods show poor performance in early diagnosis of HCC. Definite pathogenic factors contributing in the development of HCV are still lacking. MicroRNAs have been reported as promising biomarkers for cancers diagnosis and in virus-host interaction. This study was conducted to detect the role of miR-182 and miR-150 as biomarkers for development of cirrhosis and malignant transformation in HCV infected patients...
July 9, 2018: Virus Research
Weiwei Yu, Yan Wang, Guangjun Liao
PURPOSE: To investigate the effect of blood sugar level on the recurrence of hepatocellular carcinoma (HCC) after laparoscopic surgery. METHODS: The data of 177 patients with primary HCC who underwent laparoscopic radical liver resection were retrospectively analyzed. Patients were divided into the hyperglycemia group (n=56) and the control group (n=121) according to whether postoperative fasting blood sugar (FBS) was ≥6.1 mmol/L. Postoperative hospitalization and blood glucose level during follow-up were observed and recurrence and relative risk factors of HCC of patients from the two groups were analyzed...
May 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Bing Han, Hui Yao, Lichun Shao, Xiaozhong Guo, Lei Han, Fernando Gomes Romeiro, Andrea Mancuso, Xingshun Qi
PURPOSE: To explore the selection of treatment modalities for hepatocellular carcinoma (HCC) at stages T1 and/or T2 and to compare the survival of patients treated with surgery alone vs radiation therapy (RT) alone. METHODS: Surveillance, Epidemiology, and End Results (SEER) database was used to identify the patients diagnosed with HCC between 2004 and 2013. The tumor-nodemetastasis (TNM) stage was established according to the American Joint Committee on Cancer (AJCC) Staging...
May 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Jing Wu, Zhi-Mao Jiang, Yong Xie, Xuan-Qiu He, Xiao-Hua Lin, Jin-Ling Hu, Yan-Zhong Peng
PURPOSE: To identify microRNAs (miRNAs) directly regulating the proto-oncogene Bmi-1 expression in the development of hepatocellular carcinoma (HCC) and to explore the underlying molecular mechanisms. METHODS: Four HCC cell lines, including HepG2, Bel7404, Huh7, and PLC5, the normal hepatocellular cell line MIHA, and 30 HCC biopsies were included in this study. Potential miRNAs, which interact with Bmi-1 and are involved in the development of HCC were identified through bioinformatic analyses...
May 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Masashi Nakamura, Shinya Hayami, Masaki Ueno, Manabu Kawai, Atsushi Miyamoto, Norihiko Suzaki, Seiko Hirono, Ken-Ichi Okada, Motoki Miyazawa, Yuji Kitahata, Hiroki Yamaue
BACKGROUND: Radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is already fully established worldwide. Needle tract implantation and peritoneal seeding occasionally occur by RFA, and the prognosis of these cases is thought to be poor. In this study, intraoperative real-time near-infrared fluorescence (NIRF) system by indocyanine green (ICG) incidentally detected both needle tract implantation and peritoneal seeding. As the utility of this system for identification of implanted and disseminated lesions after RFA for HCC has not been widely reported, we report a case of successful detection by real-time ICG-NIRF imaging and subsequent resection...
July 13, 2018: Surgical Case Reports
Chetana Lim, Michael Osseis, Eylon Lahat, Alexandre Doussot, Dobromir Sotirov, Francois Hemery, Marc Lantéri-Minet, Cyrille Feray, Chady Salloum, Daniel Azoulay
BACKGROUND: The laparoscopic approach might increase the number of cirrhotic patients with hepatocellular carcinoma (HCC) indicated for liver resection, otherwise contraindicated due to portal hypertension. The goal of this study was to confirm the safety of laparoscopic liver resection (LLR) in patients with portal hypertension. METHODS: This prospective, single-center, open study ( ID: NCT02145013) included all consecutive cirrhotic patients who underwent LLR for HCC from 2014 to 2017...
July 12, 2018: Surgical Endoscopy
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