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https://www.readbyqxmd.com/read/28749624/synthesis-characterization-and-evaluation-of-cytotoxic-effects-of-novel-hybrid-steroidal-heterocycles-as-peg-based-nanoparticles
#1
Mervat M Abd Elhalim, Nasser S M Ismail, Shaymaa M M Yahya, Yasmin Y Omar, Ahmed A Abd Rabou, Deena S Lasheen, Mahmoud F Zawrah, Gamal A Elmegeed
Anticancer agents featuring hybrid molecules can improve effectiveness and diminish drug resistance. The current study aimed to introduce newly synthesized heterocyclic steroids of promising anticancer effects loaded in polyethylene glycol (PEG)•based nanoparticles form. Several heterocyclic steroids (1-9) were synthesized via multicomponent reactions (MCRs) and confirmed via the analytical and spectral data. Compounds 1, 2, 3, 4, 5, 6, 7 and 9, were investigated individually in their free and PEG based nano-size hybrid forms as anticancer agents against three human cell lines: hepatocellular carcinoma cells (HepG2); breast cancer cells (MCF-7); and colon cancer cells (HCT116)...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749570/hepatocyte-derived-exosomes-promote-t-follicular-regulatory-cell-expansion-during-hcv-infection
#2
Dustin A Cobb, Lucy Golden-Mason, Hugo R Rosen, Young S Hahn
Hepatitis C virus (HCV) is a global health concern that can cause severe liver disease such as cirrhosis and hepatocellular carcinoma. Control of HCV requires vigorous T cell responses, yet CD4(+) T cells in chronic HCV patients are dysfunctional. T follicular regulatory (Tfr) cells are a subset of regulatory T cells that suppress T follicular helper (Tfh) cells and the generation of high affinity antibody-producing B cells. In this study, we examined the accumulation of Tfr cells in the liver compartment during chronic HCV infection and defined the cellular and molecular mechanisms underlying their expansion...
July 27, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28749564/impact-of-sustained-virologic-response-with-direct-acting-antiviral-treatment-on-mortality-in-patients-with-advanced-liver-disease
#3
Lisa I Backus, Pamela S Belperio, Troy A Shahoumian, Larry A Mole
The impact of sustained virologic response (SVR) on mortality after direct-acting antiviral (DAA) treatment is not well documented. This study evaluated the impact of DAA-induced SVR on all-cause mortality and on incident hepatocellular carcinoma (HCC) in 15,059 HCV-infected patients with advanced liver disease defined by a FIB-4 >3.25. Overall, 1,067 patients did not achieve SVR (No SVR) and 13,992 patients achieved SVR. In a mean follow-up period of approximately 1.6 years, 195 No SVR patients and 598 SVR patients died...
July 27, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28749413/pgk1-drives-hepatocellular-carcinoma-metastasis-by-enhancing-metabolic-process
#4
Huijun Xie, Guihui Tong, Yupei Zhang, Shu Liang, Kairui Tang, Qinhe Yang
During the proliferation and metastasis, the tumor cells prefer glycolysis (Warburg effect), but its exact mechanism remains largely unknown. In this study, we demonstrated that phosphoglycerate kinase 1 (PGK1) is an important enzyme in the pathway of metabolic glycolysis. We observed a significant overexpression of PGK1 in hepatocellular carcinoma tissues, and a correlation between PGK1 expression and poor survival of hepatocellular carcinoma patients. Also, the depletion of PGK1 dramatically reduced cancer cell proliferation and metastasis, indicating an oncogenic role of PGK1 in liver cancer progression...
July 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28749119/antitumor-exopolysaccharides-derived-from-novel-marine-bacillus-isolation-characterization-aspect-and-biological-activity
#5
Salma M Abdelnasser, Shaymaa M M Yahya, Wafaa F Mohamed, Mohsen MS Asker, Hala M Abu Shady, Manal G Mahmoud, Magdy A Gadallah
Objective: Exopolysaccharides gained attention as new source for cancer treatment as recent treatments cause side effects and multidrug resistance. Polysaccharides containing sulfur and uronic acids exhibited antioxidant activity, by restoring cell redox regulation, thus inhibiting cell proliferation and cancer formation. Following this context, our study was performed to assess the cytotoxic activity of exopolysaccharides produced by novel Egyptian marine bacterial strains on HepG2 cells. Methods: Bacteria were isolated, purified and cultured through routine microbiological techniques...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28748353/mir-93-enhances-hepatocellular-carcinoma-invasion-and-metastasis-by-emt-via-targeting-pdcd4
#6
Chunmei Ji, Hang Liu, Qiang Yin, Hui Li, Han Gao
OBJECTIVES: To clarify the potential biological function of miR-93 and its related molecular mechanism underlying metastasis in human hepatocellular carcinoma (HCC). RESULTS: miR-93 was significantly up-regulated in HCC tissues and was associated with poor 5-year overall survival in HCC patients. Transwell assays showed that over-expression of miR-93 increased HCC cell migration and invasion in vitro. Programmed cell death 4 (PDCD4) was a target gene of miR-93 and miR-93 could down-regulate the expression of PDCD4 by directly targeting its 3'-UTR...
July 26, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28747982/comparative-study-of-fatty-liver-induced-by-methionine-and-choline-deficiency-in-c57bl-6n-mice-originating-from-three-different-sources
#7
Sou Hyun Kim, Yong Lim, Ju Bin Park, Jae-Hwan Kwak, Keuk-Jun Kim, Joung-Hee Kim, HyunKeun Song, Joon Young Cho, Dae Youn Hwang, Kil Soo Kim, Young-Suk Jung
Non-alcoholic fatty liver disease (NAFLD) is believed to be the most prevalent liver disease worldwide and a major cause of chronic liver injury. It is characterized by lipid accumulation in the absence of significant alcohol consumption and frequently progresses to steatohepatitis, liver fibrosis, and hepatocellular carcinoma. Although many studies have been conducted to better understand NAFLD since it was first recognized, there are still many gaps in knowledge of etiology, prognosis, prevention and treatment...
June 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/28747571/age-specific-sex-difference-in-the-incidence-of-hepatocellular-carcinoma-in-the-united-states
#8
Pian Liu, Shao-Hua Xie, Shaobo Hu, Xiang Cheng, Tianyi Gao, Chen Zhang, Zifang Song
BACKGROUND: Hepatocellular carcinoma possesses a notable sex difference in incidence, and a protective role of estrogens has been hypothesized. METHODS: Using data from 13 cancer registries in the Surveillance, Epidemiology, and End Results Program, we describe the age-specific sex difference in the incidence of hepatocellular carcinoma in the United States during 1992-2013. We used a curve fitting by non-linear regression to quantitatively characterize the age-specific incidence rate of hepatocellular carcinoma by sex...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28747554/kaempferol-induces-hepatocellular-carcinoma-cell-death-via-endoplasmic-reticulum-stress-chop-autophagy-signaling-pathway
#9
Haiqing Guo, Wei Lin, Xiangying Zhang, Xiaohui Zhang, Zhongjie Hu, Liying Li, Zhongping Duan, Jing Zhang, Feng Ren
Kaempferol is a flavonoid compound that has gained widespread attention due to its antitumor functions. However, the underlying mechanisms are still not clear. The present study investigated the effect of kaempferol on hepatocellular carcinoma and its underlying mechanisms. Kaempferol induced autophagy in a concentration- and time-dependent manner in HepG2 or Huh7 cells, which was evidenced by the significant increase of autophagy-related genes. Inhibition of autophagy pathway, through 3-methyladenine or Atg7 siRNA, strongly diminished kaempferol-induced apoptosis...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28747506/hcv-induces-the-localization-of-lipid-rafts-to-autophagosomes-for-its-rna-replication
#10
Ja Yeon Kim, Linya Wang, Jiyoung Lee, Jing-Hsiung James Ou
Autophagy plays important roles in maintaining cellular homeostasis. It uses double- or multiple- membrane vesicles termed autophagosomes to remove protein aggregates and damaged organelles from the cytoplasm for recycling. Hepatitis C virus (HCV) has been shown to induce autophagy to enhance its own replication. Here we describe a procedure that combines membrane flotation and affinity chromatography for the purification of autophagosomes from cells that harbor a HCV subgenomic RNA replicon. The purified autophagosomes had double- or multiple- membrane structures with a diameter ranging from 200 nm to 600 nm...
July 26, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28747430/ferredoxin-reductase-is-critical-for-p53-dependent-tumor-suppression-via-iron-regulatory-protein-2
#11
Yanhong Zhang, Yingjuan Qian, Jin Zhang, Wensheng Yan, Yong-Sam Jung, Mingyi Chen, Eric Huang, Kent Lloyd, Yuyou Duan, Jian Wang, Gang Liu, Xinbin Chen
Ferredoxin reductase (FDXR), a target of p53, modulates p53-dependent apoptosis and is necessary for steroidogenesis and biogenesis of iron-sulfur clusters. To determine the biological function of FDXR, we generated a Fdxr-deficient mouse model and found that loss of Fdxr led to embryonic lethality potentially due to iron overload in developing embryos. Interestingly, mice heterozygous in Fdxr had a short life span and were prone to spontaneous tumors and liver abnormalities, including steatosis, hepatitis, and hepatocellular carcinoma...
July 26, 2017: Genes & Development
https://www.readbyqxmd.com/read/28747272/efficacy-and-safety-of-radiofrequency-ablation-for-focal-hepatic-lesions-adjacent-to-gallbladder-reconfiguration-of-the-ablation-zone-through-probe-relocation-and-ablation-time-reduction
#12
In Young Choi, Pyo Nyun Kim, Sung Gu Lee, Hyung Jin Won, Yong Moon Shin
PURPOSE: To evaluate the safety and efficacy of radiofrequency (RF) ablation for treatment of focal hepatic lesions adjacent to the gallbladder with electrode relocation and ablation time reduction. MATERIALS AND METHODS: Thirty-nine patients who underwent RF ablation for focal hepatic lesions adjacent to the gallbladder (≤ 10 mm) were evaluated retrospectively from January 2011 to December 2014 (30 men and 9 women; age range, 51-85 y; mean age, 65 y). Of 36 patients with hepatocellular carcinoma, 3 had a second treatment for recurrence (mean tumor size, 15 mm ± 6)...
July 23, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28747271/diagnostic-accuracy-of-split-bolus-single-phase-contrast-enhanced-cone-beam-ct-for-the-detection-of-liver-tumors-before-transarterial-chemoembolization
#13
Martin Jonczyk, Julius Chapiro, Federico Collettini, Dominik Geisel, Dirk Schnapauff, Florian Streitparth, Thomas Schmidt, Bernd Hamm, Bernhard Gebauer, Gero Wieners
PURPOSE: To evaluate detectability of hepatocellular carcinoma (HCC) using split-bolus cone-beam CT in intraindividual comparison between cone-beam CT and contrast-enhanced MR imaging. MATERIALS AND METHODS: In a retrospective, single-center study, 28 patients with 85 HCC tumors were treated with transarterial chemoembolization between May 2015 and June 2016. All patients underwent arterial and hepatobiliary phase (HBP) MR imaging within 1 month before transarterial chemoembolization...
July 23, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28747084/mir-615-5p-depresses-natural-killer-cells-cytotoxicity-through-repressing-igf-1r-in-hepatocellular-carcinoma-patients
#14
Mai Atef Rahmoon, Rana Ahmed Youness, Asmaa Ibrahim Gomaa, Mohamed Tarif Hamza, Imam Waked, Hend Mohamed El Tayebi, Ahmed Ihab Abdelaziz
miR-615-5p was characterized by our group as a tumour suppressor. IGF-1 R activates a downstream signalling pathway, well characterized in liver cells, however, its role in immunity especially Natural Killer cells (NKs) remains vague. This study aimed at investigating the regulatory role of miR-615-5p on IGF signalling and its impact on NKs cytotoxicity in HCC. Our results showed an upregulation in miR-615-5p and IGF-1 R in NKs of 130 HCC patients compared to 35 controls. Forcing the expression of miR-615-5p, repressed IGF-IR, attenuated NKs cytotoxicity, decreased CD56(dim), increased CD56(bright) NK subsets and reduced the cytotoxic markers NKG2D, TNF-α and perforins...
July 27, 2017: Growth Factors
https://www.readbyqxmd.com/read/28747012/immunohistochemical-and-biochemical-alterations-following-administration-of-proanthocyanidin-extract-in-rats-hepatocellular-carcinoma
#15
Aya A Sherif, Somaia Z Abdelhalim, Elsayed I Salim
Grape seed proanthocyanidin extract (GSPE) is known to be effective on broad spectrum of biological pathways in living organisms including oxidative stress. The present study aimed to investigate the effects of proanthocyanidin on preneoplastic lesions and liver cancer induced in rats by Diethylnitrosamine (DEN). 7-8 Week old male Sprague Dawley (S.D.) rats were divided into six groups: The 1st group received no treatment and were -ve controls, the 2nd were treated with a single dose of DEN 200mg/kg intraperitoneally (i...
July 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28747003/baicalein-a-review-of-its-anti-cancer-effects-and-mechanisms-in-hepatocellular-carcinoma
#16
REVIEW
Beibei Bie, Jin Sun, Ying Guo, Jun Li, Wei Jiang, Jun Yang, Chen Huang, Zongfang Li
Baicalein (5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one) is a flavonoid compound derived from the roots of Scutellaria baicalensis. It has historically been used in anti-oxidant, anti-virus, anti-bacteria, anti-inflammatory and anti-allergic therapies. Recently, baicalein has been found to possess anti-cancer activities via its effect on a variety of biological processes involving cell proliferation, metastasis, apoptosis and autophagy and so on. Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies and high fatality rate worldwide...
July 21, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28746912/transcatheter-hepatic-arterial-chemoembolization-and-sorafenib-for-hepatocellular-carcinoma-a-meta-analysis-of-randomized-double-blind-controlled-trials
#17
Jun Li, Wenhui Liu, Wenhua Zhu, Yinqiao Wu, Benyan Wu
We performed a meta-analysis of transcatheter hepatic arterial chemoembolization (TACE) combined with sorafenib for hepatocellular carcinoma (HCC), which included 4 double-blind, randomized controlled trials (RCTs) that investigated the effects of TACE combined with sorafenib (experimental groups) on time to disease progression (TTP), overall survival (OS), and various sorafenib-related adverse events, compared to those in the placebo (control) groups. A total of 877 HCC cases from 14 countries, including China and the USA, were included in our meta-analysis...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28746790/long-noncoding-rna-tslnc8-is-a-tumor-suppressor-that-inactivates-the-il-6-stat3-signaling-pathway
#18
Jiwei Zhang, Zhe Li, Longzi Liu, Qifeng Wang, Shengli Li, Di Chen, Zhixiang Hu, Tao Yu, Jie Ding, Jinjun Li, Ming Yao, Shenglin Huang, Yingjun Zhao, Xianghuo He
Long noncoding RNAs (lncRNAs) can serve as oncogenes or tumor suppressors in human cancer; however, their biological functions and underlying mechanism in hepatocarcinogenesis are largely unknown. Here, we report a novel tumor suppressor lncRNA on chromosome 8p12 (termed TSLNC8) that is frequently deleted and downregulated in hepatocellular carcinoma (HCC) tissues. The loss of TSLNC8 is highly associated with the malignant features of HCC and serves as a prognostic indicator for HCC patients. TSLNC8 significantly suppresses the proliferation and metastasis of HCC cells in vitro and in vivo...
July 26, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28746788/a-randomized-placebo-controlled-trial-of-prophylactic-dexamethasone-for-transcatheter-arterial-chemoembolization
#19
Sadahisa Ogasawara, Tetsuhiro Chiba, Yoshihiko Ooka, Naoya Kanogawa, Tenyu Motoyama, Eiichiro Suzuki, Akinobu Tawada, Kazue Nagai, Tomoo Nakagawa, Takeshi Sugawara, Hideki Hanaoka, Fumihiko Kanai, Osamu Yokosuka
This randomized, double-blind, placebo-controlled trial evaluated dexamethasone efficacy in preventing fever, anorexia, and nausea/vomiting, the most frequent adverse events of transcatheter arterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC). Child-Pugh class A/B patients with HCC and no macrovascular invasion/extrahepatic metastases were randomly assigned to either a dexamethasone (day 1, intravenous dexamethasone [20 mg] and granisetron [3 mg] before TACE; days 2 and 3, intravenous dexamethasone [8 mg]) or a control regimen (day 1, intravenous placebo [saline] and granisetron [3 mg]; days 2 and 3, intravenous placebo)...
July 26, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28746230/tace-plus-percutaneous-chemotherapy-lipiodol-treatment-of-unresectable-pedunculated-hepatocellular-carcinoma
#20
Dexiao Huang, Yong Chen, Shuo Chen, Qingle Zeng, Jianbo Zhao, Renhua Wu, Yanhao Li
Pedunculated hepatocellular carcinoma (P-HCC) is rare type of HCC. The study aimed to evaluate the clinical features and outcomes of unresectable P-HCC treated with transcatheter arterial chemoembolization (TACE) and percutaneous chemotherapeutic agents lipiodol emulsion (CALE) injection. The clinical features and outcomes of 25 patients with unresectable P-HCC treated with TACE plus percutaneous CALE injection were retrospectively reviewed, and factors associated with outcomes were analyzed. Comparison with nonpedunculated unresectable HCC was also performed...
July 2017: Medicine (Baltimore)
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