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https://www.readbyqxmd.com/read/28806768/design-and-fabrication-of-a-realistic-anthropomorphic-heterogeneous-head-phantom-for-mr-purposes
#1
Sossena Wood, Narayanan Krishnamurthy, Tales Santini, Shailesh Raval, Nadim Farhat, John Andy Holmes, Tamer S Ibrahim
OBJECTIVE: The purpose of this study is to design an anthropomorphic heterogeneous head phantom that can be used for MRI and other electromagnetic applications. MATERIALS AND METHODS: An eight compartment, physical anthropomorphic head phantom was developed from a 3T MRI dataset of a healthy male. The designed phantom was successfully built and preliminarily evaluated through an application that involves electromagnetic-tissue interactions: MRI (due to it being an available resource)...
2017: PloS One
https://www.readbyqxmd.com/read/28806354/trends-in-adult-chlamydia-and-gonorrhea-prevalence-incidence-and-urethral-discharge-case-reporting-in-morocco-over-1995-2015-estimates-using-the-spectrum-sexually-transmitted-infection-model
#2
Amina El-Kettani, Guy Mahiané, Aziza Bennani, Laith Abu-Raddad, Alex Smolak, Jane Rowley, Nico Nagelkerke, Houssine El-Rhilani, Kamal Alami, Amina Hançali, Eline Korenromp
BACKGROUND: Evolving health priorities and resource constraints mean that countries require data on sexually transmitted infections (STI) trends to inform program planning and resource allocation. METHODS: The Spectrum modeling tool estimated prevalence and incidence of gonorrhea and chlamydia in Morocco's 15- to 49-year-old population, based on prevalence surveys. Incident cases, broken down between symptomatic and asymptomatic, and treated versus untreated, were compared with urethral discharge (UD) case reports, to estimate reporting completeness among treated UD cases...
September 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28805631/bumble-bee-ecophysiology-integrating-the-changing-environment-and-the-organism
#3
REVIEW
S Hollis Woodard
Bumble bees are among the most ecologically and economically important pollinators worldwide, yet many of their populations are being threatened by a suite of interrelated, human-mediated environmental changes. Here, I discuss recent progress in our understanding of bumble bee ecophysiology, including advances related to thermal biology in light of global warming; nutritional biology in the context of declining food resources; and the capacity for bumble bees to exhibit physiological plasticity or adaptations to novel or extreme environments, with reference to their evolutionary history and current biogeography...
August 2017: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/28805419/creating-space-for-relationships
#4
Susan L Maataoui, Jodi S Hardwick, Tessa S Lundquist
Sexuality is a key component of personality and behavior, encompassing basic human needs for touch, intimacy, love, affection, and sexual behavior. The design of long-term care facilities makes it almost impossible for a resident to be sexually intimate, to share romantic moments, or to have a meal in a private setting. This case study describes the rationale and process used to establish a private guestroom called the Family Room at Patriots Place, the specialized dementia unit in the Veterans Affairs (VA) Maine Healthcare System Community Living Center (CLC)...
August 2017: Psychological Services
https://www.readbyqxmd.com/read/28803971/otp-an-automatized-system-for-managing-and-processing-ngs-data
#5
Eva Reisinger, Lena Genthner, Jules Kerssemakers, Philip Kensche, Stefan Borufka, Alke Jugold, Andreas Kling, Manuel Prinz, Ingrid Scholz, Gideon Zipprich, Roland Eils, Christian Lawerenz, Jürgen Eils
The One Touch Pipeline (OTP) is an automation platform managing Next-Generation Sequencing (NGS) data and calling bioinformatic pipelines for processing these data. OTP handles the complete digital process from import of raw sequence data via alignment of sequencing reads to identify genomic events in an automated and scalable way. Three major goals are pursued: firstly, reduction of human resources required for data management by introducing automated processes. Secondly, reduction of time until the sequences can be analyzed by bioinformatic experts, by executing all operations more reliably and quickly...
August 10, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28803589/health-technology-assessment-in-central-eastern-and-south-european-countries-croatia
#6
Mirjana Huic, Romana Tandara Hacek, Ivan Svajger
OBJECTIVES: The aim of this study was to provide a brief, 7-year history of health technology assessment (HTA) implementation in Croatia through national and international activities. METHODS: We used retrospective descriptive analysis of key documents related to the legal framework, process of decision making, and HTA. Analysis of the Agency's plan for and experience with the implementation of a transparent HTA process in Croatia was performed by addressing seven key components of the HTA implementation scorecard framework...
August 14, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28802249/high-resolution-mapping-of-chromatin-conformation-in-cardiac-myocytes-reveals-structural-remodeling-of-the-epigenome-in-heart-failure
#7
Manuel Rosa-Garrido, Douglas J Chapski, Anthony D Schmitt, Todd H Kimball, Elaheh Karbassi, Emma Monte, Enrique Balderas, Matteo Pellegrini, Tsai-Ting Shih, Elizabeth Soehalim, David A Liem, Peipei Ping, Niels J Galjart, Shuxun Ren, Yibin Wang, Bing Ren, Thomas M Vondriska
Background -Cardiovascular disease is associated with epigenomic changes in the heart, however the endogenous structure of cardiac myocyte chromatin has never been determined. Methods -To investigate the mechanisms of epigenomic function in the heart, genome-wide chromatin conformation capture (Hi-C) and DNA sequencing were performed in adult cardiac myocytes following development of pressure overload-induced hypertrophy. Mice with cardiac-specific deletion of CTCF (a ubiquitous chromatin structural protein) were generated to explore the role of this protein in chromatin structure and cardiac phenotype...
August 11, 2017: Circulation
https://www.readbyqxmd.com/read/28801763/a-situational-analysis-of-breast-cancer-early-detection-services-in-trinidad-and-tobago
#8
Kimberly Badal, Fidel Rampersad, Wayne A Warner, Adetunji T Toriola, Hamish Mohammed, Harold-Alexis Scheffel, Rehanna Ali, Murrie Moosoodeen, Siva Konduru, Adaila Russel, Rajini Haraksingh
PURPOSE: A situational analysis of breast cancer (BC) early detection services was carried out to investigate whether Trinidad and Tobago (T&T) has the framework for successful organized national screening. METHODS: An online survey was designed to assess the availability, accessibility, quality control and assurance (QC&A), and monitoring and evaluation (M&E) mechanisms for public and private BC early detection. A focus group with local radiologists (n = 3) was held to identify unaddressed challenges and make recommendations for improvement...
August 11, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28800978/modelling-landscape-dynamics-with-lst-in-protected-areas-of-western-ghats-karnataka
#9
T V Ramachandra, Setturu Bharath, Nimish Gupta
Forest ecosystems sustain biota on the earth as they are habitat to diverse biotic species, arrests soil erosion, play a crucial role in water cycle, sequester carbon, and helps in mitigating the impacts of global warming. Large scale land use land cover (LULC) change leading to deforestation is one of the drivers of global climate changes and alteration of biogeochemical cycles with significant consequences in ecosystem services and biodiversity. This has necessitated the investigation of LULC by mapping, monitoring and modelling spatio-temporal patterns and evaluating these in the context of human-environment interactions...
August 8, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28800810/international-emergency-psychiatry-challenges-disaster-medicine-war-human-trafficking-displaced-persons
#10
REVIEW
Michael Jaung, Suni Jani, Sophia Banu, Joy M Mackey
Mental health disorders are a major cause of morbidity and a growing burden in low-income and middle-income countries; but there is little existing literature on the detailed epidemiology, diagnosis, and treatment in low-resource settings. Special situations with vulnerable populations, such as those created by international humanitarian emergencies, refugees or internally displaced people, and victims of human trafficking, are increasing in prevalence. These victims are often resettled in developed countries and come to the emergency department seeking care...
September 2017: Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/28800348/disability-management-and-organizational-culture-in-australia-and-canada
#11
Nicholas Buys, Shannon Wagner, Christine Randall, Henry Harder, Thomas Geisen, Ignatius Yu, Benedikt Hassler, Caroline Howe, Alex Fraess-Phillips
BACKGROUND: Organizational culture has received increasing attention in terms of its influence on workplace health and productivity, yet there has been little research on its relationship with employer-based disability programs. OBJECTIVE: This study explored the relationship between disability management and organizational culture in Australian and Canadian organizations. METHODS: Thematic analysis was conducted on data from semi-structured interviews with 16 employees, including injured workers, human resource managers and disability managers in two Australian and two Canadian large organizations...
2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28799592/rapid-determination-of-the-tumour-stroma-ratio-in-squamous-cell-carcinomas-with-desorption-electrospray-ionization-mass-spectrometry-desi-ms-a-proof-of-concept-demonstration
#12
Michael Woolman, Alessandra Tata, Delaram Dara, Jalna Meens, Elisa D'Arcangelo, Consuelo J Perez, Shamina Saiyara Prova, Emma Bluemke, Howard J Ginsberg, Demian Ifa, Alison McGuigan, Laurie Ailles, Arash Zarrine-Afsar
Squamous cell carcinomas constitute a major class of head & neck cancers, where the tumour stroma ratio (TSR) carries prognostic information. Patients affected by stroma-rich tumours exhibit a poor prognosis and a higher chance of relapse. As such, there is a need for a technology platform that allows rapid determination of the tumour stroma ratio. In this work, we provide a proof-of-principle demonstration that Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) can be used to determine tumour stroma ratios...
August 11, 2017: Analyst
https://www.readbyqxmd.com/read/28799483/ethical-application-of-precision-medicine-to-schizophrenia-management
#13
Steven Daws
A recent effort has been made to better characterize the genetic architecture of schizophrenia, and apply a precision medicine model to its treatment. In pursuing this approach, it is likely that ethical concerns regarding cost-benefit uncertainties, the duty to inform and confidentiality will arise. Due to the complexity of schizophrenia's genetic profile, research efforts must be weighed against the risk to human subjects and the required consumption of valuable healthcare resources. Genetic risk profiles must be judged in conjunction with actionability and must be fully explained to patients and others potentially affected...
July 2017: New Bioethics: a Multidisciplinary Journal of Biotechnology and the Body
https://www.readbyqxmd.com/read/28799245/when-and-where-to-move-dynamic-occupancy-models-explain-the-range-dynamics-of-a-food-nomadic-bird-under-climate-and-land-cover-change
#14
Riddhika Kalle, Tharmalingam Ramesh, Colleen T Downs
Globally, long-term research is critical to monitor the responses of tropical species to climate and land cover change at the range scale. Citizen science surveys can reveal the long-term persistence of poorly known nomadic tropical birds occupying fragmented forest patches. We applied dynamic occupancy models to 13 years (2002-2014) of citizen science driven presence/absence data on Cape parrot (Poicephalus robustus), a food nomadic bird endemic to South Africa. We modelled its underlying range dynamics as a function of resource distribution, and change in climate and land cover through the estimation of colonization and extinction patterns...
August 11, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28798757/establishing-the-bases-for-introducing-the-unexplored-portuguese-common-bean-germplasm-into-the-breeding-world
#15
Susana T Leitão, Marco Dinis, Maria M Veloso, Zlatko Šatović, Maria C Vaz Patto
Common bean (Phaseolus vulgaris L.) is among the most important grain legumes for human consumption worldwide. Portugal has a potentially promising common bean germplasm, resulting from more than five centuries of natural adaptation and farmers' selection. Nevertheless, limited characterization of this resource hampers its exploitation by breeding programs. To support a more efficient conservation of the national bean germplasm and promote its use in crop improvement, we performed, for the first time, a simultaneous molecular marker (21 microsatellites and a DNA marker for phaseolin-type diversity analysis) and seed and plant morphological characterization (14 traits) of 175 accessions from Portuguese mainland and islands traditional bean-growing regions...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28798274/disparities-of-trastuzumab-use-in-resource-limited-or-resource-abundant-regions-and-its-survival-benefit-on-her2-positive-breast-cancer-a-real-world-study-from-china
#16
Jianbin Li, Shusen Wang, Yongsheng Wang, Xiaojia Wang, Haibo Wang, Jifeng Feng, Qingyuan Zhang, Tao Sun, Quchang Ouyang, Yongmei Yin, Yinhua Liu, Cuizhi Geng, Min Yan, Zefei Jiang
BACKGROUND: Trastuzumab is a key component of therapy for human epidermal growth receptor 2 (HER2) positive breast cancer. Because real-world data are lacking, the present research was conducted to evaluate the the actual use of and the effectiveness of trastuzumab in the real world in China. METHODS: Inpatients with HER2 positive invasive breast cancer from 13 hospitals in Eastern China (2010-2015, n = 1,139) were included in this study. We aimed to assess the actual use of trastuzumab and to evaluate potential efficacy from trastuzumab in real-world research...
August 10, 2017: Oncologist
https://www.readbyqxmd.com/read/28798251/lungmap-the-molecular-atlas-of-lung-development-program
#17
Maryanne E Ardini-Poleske, Robert Fred Clark, Charles Ansong, James P Carson, Richard A Corley, Gail H Deutsch, James S Hagood, Naftali Kaminski, Thomas J Mariani, Steven S Potter, Gloria S Pryhuber, David Warburton, Jeffrey A Whitsett, Scott M Palmer, Namasivayam Ambalavanan, The LungMAP Consortium
The National Heart Lung and Blood Institute is funding an effort to create a molecular atlas of the developing lung (LungMAP) to serve as a research resource and public education tool. The lung is a complex organ with lengthy development time driven by interactive gene networks and dynamic crosstalk among multiple cell types to control and coordinate lineage specification, cell proliferation, differentiation, migration, morphogenesis and injury repair. A better understanding of the processes that regulate lung development, particularly alveologenesis, will have significant impact on survival rates for premature infants born with incomplete lung development and will facilitate lung injury repair and regeneration in adults...
August 10, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28797648/overview-of-transcriptomic-analysis-of-all-human-proteases-non-proteolytic-homologs-and-inhibitors-organ-tissue-and-ovarian-cancer-cell-line-expression-profiling-of-the-human-protease-degradome-by-the-clip-chip%C3%A2-dna-microarray
#18
REVIEW
Reinhild Kappelhoff, Xose S Puente, Claire H Wilson, Arun Seth, Carlos Lopez-Otin, Christopher M Overall
The protease degradome is defined as the complete repertoire of proteases and inhibitors, and their nonfunctional homologs present in a cell, tissues or organism at any given time. We review the tissue distribution of virtually the entire degradome in 23 different human tissues and 6 ovarian cancer cell lines. To do so, we developed the CLIP-CHIP™, a custom microarray based on a 70-mer oligonucleotide platform, to specifically profile the transcripts of the entire repertoire of 473 active human proteases, 156 protease inhibitors and 92 non-proteolytically active homologs known at the design date using one specific oligonucleotide per transcript...
August 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28797540/efficiency-of-two-sewage-treatment-systems-activated-sludge-and-natural-lagoons-for-helminth-egg-removal-in-morocco
#19
Sana Chaoua, Samia Boussaa, Ahmed Khadra, Ali Boumezzough
Morocco is a country known for its vulnerability of water resources because of its arid and semi-arid climate. Thus, recycled wastewater has been suggested for agricultural activities, but contamination of these wastewaters is a major concern. The current study aims to determine the occurrence of helminth eggs in urban wastewater and to evaluate the removal of these pathogens by two sewage treatment systems: activated sludge and natural lagoons. The samples of wastewater and sludge were collected from two wastewater treatment plants (WWTP) located in Marrakech and Chichaoua, Morocco...
August 7, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28797273/host-immune-responses-to-the-itch-mite-sarcoptes-scabiei-in-humans
#20
REVIEW
Sajad A Bhat, Kate E Mounsey, Xiaosong Liu, Shelley F Walton
Scabies is a parasitic disease due to infestation of skin by the burrowing mite Sarcoptes scabiei. Scabies is a major public health problem and endemic in resource poor communities worldwide affecting over 100 million people. Associated bacterial infections cause substantial morbidity, and in severe cases can lead to renal and cardiac diseases. Mite infestation of the skin causes localised cutaneous inflammation, pruritus, skin lesions, and allergic and inflammatory responses are mounted by the host against the mite and its products...
August 10, 2017: Parasites & Vectors
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