keyword
https://read.qxmd.com/read/38537199/fopgdb-a-pangenome-database-of-fusarium-oxysporum-a-cross-kingdom-fungal-pathogen
#1
JOURNAL ARTICLE
Tan Meng, Hanqing Jiao, Yi Zhang, Yi Zhou, Shaoying Chen, Xinrui Wang, Bowen Yang, Jie Sun, Xin Geng, Dilay Hazal Ayhan, Li Guo
Pangenomes, capturing the genetic diversity of a species or genus, are essential to understanding the ecology, pathobiology and evolutionary mechanisms of fungi that cause infection in crops and humans. However, fungal pangenome databases remain unavailable. Here, we report the first fungal pangenome database, specifically for Fusarium oxysporum species complex (FOSC), a group of cross-kingdom pathogens causing devastating vascular wilt to over 100 plant species and life-threatening fusariosis to immunocompromised humans...
March 27, 2024: Database: the Journal of Biological Databases and Curation
https://read.qxmd.com/read/38537150/prediction-of-occult-hemorrhage-in-the-lower-body-negative-pressure-model-initial-validation-of-machine-learning-approaches
#2
JOURNAL ARTICLE
Navid Rashedi, Yifei Sun, Vikrant Vaze, Parikshit Shah, Ryan Halter, Jonathan T Elliott, Norman A Paradis
INTRODUCTION: Detection of occult hemorrhage (OH) before progression to clinically apparent changes in vital signs remains an important clinical problem in managing trauma patients. The resource-intensiveness associated with continuous clinical patient monitoring and rescue from frank shock makes accurate early detection and prediction with noninvasive measurement technology a desirable innovation. Despite significant efforts directed toward the development of innovative noninvasive diagnostics, the implementation and performance of the newest bedside technologies remain inadequate...
March 27, 2024: Military Medicine
https://read.qxmd.com/read/38536851/the-motivations-and-experiences-of-specialists-who-provide-outreach-services-in-rural-operating-rooms-a-survey-study-from-british-columbia
#3
JOURNAL ARTICLE
Anshu Parajulee, Kathrin Stoll, Nancy Humber, Sean Ebert, Kim Williams, Jude Kornelsen
INTRODUCTION: Outreach care has long been used in Canada to address the lack of access to specialist care in rural settings, but research on the experiences of specialists providing these services is lacking. This descriptive survey study aimed to understand 1) specialists' motivation for engaging in outreach work, (2) their perceptions of the quality of care at their rural outreach hospital, and (3) the supports they receive for their outreach work, in order to create a supportive framework to encourage specialist outreach contributions...
2024: PloS One
https://read.qxmd.com/read/38536809/enhanced-dietary-reconstruction-of-korean-prehistoric-populations-by-combining-%C3%AE-13c-and-%C3%AE-15n-amino-acids-of-bone-collagen
#4
JOURNAL ARTICLE
Kyungcheol Choy, Hee Young Yun, Benjamin T Fuller, Marcello A Mannino
Compound specific stable isotope analysis of amino acids (CSIA-AA) is a powerful tool for determining dietary behaviors in complex environments and improving dietary reconstructions. Here, we conducted CSIA-AA on human (n = 32) and animal (n = 13) remains from two prehistoric archaeological sites (Mumun, Imdang) to assess in more detail the dietary sources consumed by prehistoric Korean populations. Results of estimated trophic position (TP) using Δ15NGlx-Phe show that the Imdang individuals consumed aquatic resources, as well as terrestrial resources...
2024: PloS One
https://read.qxmd.com/read/38536222/bridging-and-bonding-social-capital-by-analyzing-the-demographics-user-activities-and-social-network-dynamics-of-sexual-assault-centers-on-twitter-mixed-methods-study
#5
JOURNAL ARTICLE
Jia Xue, Qiaoru Zhang, Yun Zhang, Hong Shi, Chengda Zheng, Jingchuan Fan, Linxiao Zhang, Chen Chen, Luye Li, Micheal L Shier
BACKGROUND: Social media platforms have gained popularity as communication tools for organizations to engage with clients and the public, disseminate information, and raise awareness about social issues. From a social capital perspective, relationship building is seen as an investment, involving a complex interplay of tangible and intangible resources. Social media-based social capital signifies the diverse social networks that organizations can foster through their engagement on social media platforms...
March 27, 2024: Journal of Medical Internet Research
https://read.qxmd.com/read/38535974/are-rehabilitation-professionals-familiar-with-visual-impairments-a-survey-of-professional-orders-in-quebec-canada
#6
JOURNAL ARTICLE
Joseph P Nemargut, Geneviève Boucher-Costi, Angel Ta, Laurie St-Amant
SIGNIFICANCE: The number of patients with mild to moderate visual impairments (MVIs) is increasing as the average age of the population increases. Thus, it is important to understand the training and resources available for rehabilitation practitioners to provide adequate care to these patients within their scope of practice. PURPOSE: This study explores rehabilitation professionals' perceptions of their competence in screening and treating patients with MVI, and identifying the tools and resources needed to increase these professionals' comfort level in managing these patients...
March 18, 2024: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://read.qxmd.com/read/38535366/spotted-fever-group-rickettsia-spp-molecular-and-serological-evidence-among-colombian-vectors-and-animal-hosts-a-historical-review
#7
REVIEW
Lídia Gual-Gonzalez, Myriam E Torres, Stella C W Self, Omar Cantillo-Barraza, Melissa S Nolan
Spotted fever group Rickettsia spp. (SFGR) are a large group of tick-borne bacteria causing important emerging and re-emerging diseases that affect animals and humans. While SFGR are found worldwide, a lack of surveillance and misdiagnosis particularly affect South American countries. Colombia is a high burdened country in South America, yet rickettsioses are not deemed a nationally reportable condition limiting disease-specific public health resources. As mortality rates are high for one Rickettsia pathogen species, there is a great need to better understand the epidemiological and ecological factors that increase SFGR transmission risk regionally...
March 2, 2024: Insects
https://read.qxmd.com/read/38534797/power-analysis-for-human-melatonin-suppression-experiments
#8
JOURNAL ARTICLE
Manuel Spitschan, Parisa Vidafar, Sean W Cain, Andrew J K Phillips, Ben C Lambert
In humans, the nocturnal secretion of melatonin by the pineal gland is suppressed by ocular exposure to light. In the laboratory, melatonin suppression is a biomarker for this neuroendocrine pathway. Recent work has found that individuals differ substantially in their melatonin-suppressive response to light, with the most sensitive individuals being up to 60 times more sensitive than the least sensitive individuals. Planning experiments with melatonin suppression as an outcome needs to incorporate these individual differences, particularly in common resource-limited scenarios where running within-subjects studies at multiple light levels is costly and resource-intensive and may not be feasible with respect to participant compliance...
February 26, 2024: Clocks & Sleep
https://read.qxmd.com/read/38534696/current-therapeutic-approaches-for-multidrug-resistant-and-extensively-drug-resistant-acinetobacter-baumannii-infections
#9
REVIEW
Petros Rafailidis, Periklis Panagopoulos, Christos Koutserimpas, George Samonis
The treatment of Acinetobacter baumannii infections remains a challenge for physicians worldwide in the 21st century. The bacterium possesses a multitude of mechanisms to escape the human immune system. The consequences of A. baumannii infections on morbidity and mortality, as well on financial resources, remain dire. Furthermore, A. baumannii superinfections have also occurred during the COVID-19 pandemic. While prevention is important, the antibiotic armamentarium remains the most essential factor for the treatment of these infections...
March 15, 2024: Antibiotics
https://read.qxmd.com/read/38534629/hydrogels-based-on-chitosan-and-nanoparticles-and-their-suitability-for-dyes-adsorption-from-aqueous-media-assessment-of-the-last-decade-progresses
#10
REVIEW
Cristina-Gabriela Grigoraș, Andrei-Ionuț Simion, Cătălin Drob
Water is one of the fundamental resources for the existence of humans and the environment. Throughout time, due to urbanization, expanding population, increased agricultural production, and intense industrialization, significant pollution with persistent contaminants has been noted, placing the water quality in danger. As a consequence, different procedures and various technologies have been tested and used in order to ensure that water sources are safe for use. The adsorption process is often considered for wastewater treatment due to its straightforward design, low investment cost, availability, avoidance of additional chemicals, lack of undesirable byproducts, and demonstrated significant efficacious potential for treating and eliminating organic contaminants...
March 21, 2024: Gels
https://read.qxmd.com/read/38534540/brain-tumor-detection-and-categorization-with-segmentation-of-improved-unsupervised-clustering-approach-and-machine-learning-classifier
#11
JOURNAL ARTICLE
Usharani Bhimavarapu, Nalini Chintalapudi, Gopi Battineni
There is no doubt that brain tumors are one of the leading causes of death in the world. A biopsy is considered the most important procedure in cancer diagnosis, but it comes with drawbacks, including low sensitivity, risks during biopsy treatment, and a lengthy wait for results. Early identification provides patients with a better prognosis and reduces treatment costs. The conventional methods of identifying brain tumors are based on medical professional skills, so there is a possibility of human error. The labor-intensive nature of traditional approaches makes healthcare resources expensive...
March 8, 2024: Bioengineering
https://read.qxmd.com/read/38534402/transgene-free-cynomolgus-monkey-ipscs-generated-under-chemically-defined-conditions
#12
JOURNAL ARTICLE
Yuliia Tereshchenko, Nesil Esiyok, Enrique Garea-Rodríguez, Daniele Repetto, Rüdiger Behr, Ignacio Rodríguez-Polo
Non-human primates (NHPs) are pivotal animal models for translating novel cell replacement therapies into clinical applications, including validating the safety and efficacy of induced pluripotent stem cell (iPSC)-derived products. Preclinical development and the testing of cell-based therapies ideally comprise xenogeneic (human stem cells into NHPs) and allogenic (NHP stem cells into NHPs) transplantation studies. For the allogeneic approach, it is necessary to generate NHP-iPSCs with generally equivalent quality to the human counterparts that will be used later on in patients...
March 21, 2024: Cells
https://read.qxmd.com/read/38534218/sound-the-alarm-the-sonographer-shortage-is-echoing-across-healthcare
#13
JOURNAL ARTICLE
Daniel Won, James Walker, Russ Horowitz, Sandeep Bharadwaj, Edward Carlton, Helena Gabriel
OBJECTIVES: The growth in ultrasound usage necessitates concurrent growth in the number of sonographers. Despite the increasing importance of ultrasound, there is a shortage of sonographers in the United States that has never been specifically quantified. This study examines recent trends in the number of ultrasound exams, sonography graduates, open sonographer positions, and wages. METHODS: This retrospective study uses public databases and surveys including the Medical Expenditure Panel Survey (MEPS), Bureau of Labor Statistics (BLS), Integrated Postsecondary Education Data System (IPEDS), and Zippia, a human resources platform to determine metrics...
March 27, 2024: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://read.qxmd.com/read/38533909/use-of-nonhuman-sera-as-a-highly-cost-effective-internal-standard-for-quantitation-of-multiple-human-proteins-using-species-specific-tryptic-peptides-applicability-in-clinical-lc-ms-analyses
#14
JOURNAL ARTICLE
Geraldine Williams, Lewis Couchman, David R Taylor, Jatinderpal K Sandhu, Oliver C Slingsby, Leong L Ng, Cajetan F Moniz, Donald J L Jones, Colleen B Maxwell
Quantitation of proteins using liquid chromatography-tandem mass spectrometry (LC-MS/MS) is complex, with a multiplicity of options ranging from label-free techniques to chemically and metabolically labeling proteins. Increasingly, for clinically relevant analyses, stable isotope-labeled (SIL) internal standards (ISs) represent the "gold standard" for quantitation due to their similar physiochemical properties to the analyte, wide availability, and ability to multiplex to several peptides. However, the purchase of SIL-ISs is a resource-intensive step in terms of cost and time, particularly for screening putative biomarker panels of hundreds of proteins...
March 27, 2024: Journal of Proteome Research
https://read.qxmd.com/read/38533632/mental-health-in-ukraine-in-2023
#15
JOURNAL ARTICLE
Dmytro Martsenkovskyi, Mark Shevlin, Menachem Ben-Ezra, Kristina Bondjers, Robert Fox, Thanos Karatzias, Inna Martsenkovska, Igor Martsenkovsky, Elisa Pfeiffer, Cedric Sachser, Frédérique Vallières, Philip Hyland
BACKGROUND: Very little is known about the mental health of the adult population of Ukraine following Russia's full-scale invasion in February 2022. In this study, we estimated the prevalence of seven mental health disorders, the proportion of adults screening positive for any disorder, and the sociodemographic factors associated with meeting requirements for each and any disorder. METHODS: A non-probability quota sample ( N  = 2,050) of adults living in Ukraine in September 2023 was collected online...
March 27, 2024: European Psychiatry: the Journal of the Association of European Psychiatrists
https://read.qxmd.com/read/38532378/biosafe-cerium-oxide-nanozymes-protect-human-pluripotent-stem-cells-and-cardiomyocytes-from-oxidative-stress
#16
JOURNAL ARTICLE
Chengwen Hang, Mohamed S Moawad, Zheyi Lin, Huixin Guo, Hui Xiong, Mingshuai Zhang, Renhong Lu, Junyang Liu, Dan Shi, Duanyang Xie, Yi Liu, Dandan Liang, Yi-Han Chen, Jian Yang
BACKGROUND: Cardiovascular diseases (CVDs) have the highest mortality worldwide. Human pluripotent stem cells (hPSCs) and their cardiomyocyte derivatives (hPSC-CMs) offer a valuable resource for disease modeling, pharmacological screening, and regenerative therapy. While most CVDs are linked to significant over-production of reactive oxygen species (ROS), the effects of current antioxidants targeting excessive ROS are limited. Nanotechnology is a powerful tool to develop antioxidants with improved selectivity, solubility, and bioavailability to prevent or treat various diseases related to oxidative stress...
March 26, 2024: Journal of Nanobiotechnology
https://read.qxmd.com/read/38532217/evaluating-hydrogeochemistry-and-heavy-metal-contamination-of-groundwater-at-ranipet-environs-employing-multivariate-statistics-agricultural-indices-and-health-risk-assessment
#17
JOURNAL ARTICLE
Loganathan Krishnamoorthy, Vignesh Rajkumar Lakshmanan
Water plays an essential role in sustaining life on Earth as an indispensable natural resource. In recent decades, dependence on groundwater for domestic and industrial purposes has become inevitable. The Ranipet industrial environs (RIE) has many tanneries and chemical industries, which affects the groundwater quality. This study assessed groundwater quality and its suitability for domestic, agricultural, and human health risk assessments. 40 groundwater samples (28 open wells and 12 bore wells) were collected during pre-monsoon 2022 and analyzed by employing multivariate statistics, standard scatter plots, irrigation indices, and health risk assessment...
March 27, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38532065/multi-criteria-decision-analysis-framework-for-engaging-stakeholders-in-river-pollution-risk-management
#18
JOURNAL ARTICLE
Zesizwe Ngubane, Viktor Bergion, Bloodless Dzwairo, Thor Axel Stenström, Ekaterina Sokolova
Water pollution presents a substantial environmental challenge with extensive implications for water resources, ecosystem sustainability, and human health. Using a South African catchment, this study aimed to provide watershed managers with a framework for selecting best management practices (BMPs) to reduce pollution and the related risk to river users, while also including the perspectives of key catchment stakeholders. The framework encompassed the identification of and consultation with key stakeholders within the catchment...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38532024/a-precision-functional-atlas-of-personalized-network-topography-and-probabilities
#19
JOURNAL ARTICLE
Robert J M Hermosillo, Lucille A Moore, Eric Feczko, Óscar Miranda-Domínguez, Adam Pines, Ally Dworetsky, Gregory Conan, Michael A Mooney, Anita Randolph, Alice Graham, Babatunde Adeyemo, Eric Earl, Anders Perrone, Cristian Morales Carrasco, Johnny Uriarte-Lopez, Kathy Snider, Olivia Doyle, Michaela Cordova, Sanju Koirala, Gracie J Grimsrud, Nora Byington, Steven M Nelson, Caterina Gratton, Steven Petersen, Sarah W Feldstein Ewing, Bonnie J Nagel, Nico U F Dosenbach, Theodore D Satterthwaite, Damien A Fair
Although the general location of functional neural networks is similar across individuals, there is vast person-to-person topographic variability. To capture this, we implemented precision brain mapping functional magnetic resonance imaging methods to establish an open-source, method-flexible set of precision functional network atlases-the Masonic Institute for the Developing Brain (MIDB) Precision Brain Atlas. This atlas is an evolving resource comprising 53,273 individual-specific network maps, from more than 9,900 individuals, across ages and cohorts, including the Adolescent Brain Cognitive Development study, the Developmental Human Connectome Project and others...
March 26, 2024: Nature Neuroscience
https://read.qxmd.com/read/38532014/dip-ms-ultra-deep-interaction-proteomics-for-the-deconvolution-of-protein-complexes
#20
JOURNAL ARTICLE
Fabian Frommelt, Andrea Fossati, Federico Uliana, Fabian Wendt, Peng Xue, Moritz Heusel, Bernd Wollscheid, Ruedi Aebersold, Rodolfo Ciuffa, Matthias Gstaiger
Most proteins are organized in macromolecular assemblies, which represent key functional units regulating and catalyzing most cellular processes. Affinity purification of the protein of interest combined with liquid chromatography coupled to tandem mass spectrometry (AP-MS) represents the method of choice to identify interacting proteins. The composition of complex isoforms concurrently present in the AP sample can, however, not be resolved from a single AP-MS experiment but requires computational inference from multiple time- and resource-intensive reciprocal AP-MS experiments...
March 26, 2024: Nature Methods
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