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exosome and angiogenesis

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https://www.readbyqxmd.com/read/29774141/exosome-mediated-peritoneal-dissemination-in-gastric-cancer-and-its-clinical-applications
#1
REVIEW
Kai-Bo Chen, Jian Chen, Xiao-Li Jin, Yi Huang, Qiu-Ming Su, Li Chen
The prognosis of patients with peritoneal dissemination from gastric cancer is poor, and the underlying molecular mechanism remains unclear. Exosomes, as macromolecular phospholipid bilayer vesicles comprising of proteins, nucleic acids and lipids, serve as mediators of cell-cell communication. Gastric cancer tumor-derived exosomes may be involved in the pathological process of peritoneal dissemination by mediating crosstalk between cancer cells and mesothelial cells, to result in the induction of enhanced tumor growth, migratory, adhesive and invasive abilities, peritoneal fibrosis and apoptosis, mesothelial-to-mesenchymal transition, angiogenesis and chemoresistance...
June 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29772339/wound-healing-effects-of-a-curcuma-zedoaria-polysaccharide-with-platelet-rich-plasma-exosomes-assembled-on-chitosan-silk-hydrogel-sponge-in-a-diabetic-rat-model
#2
Ning Xu, Lili Wang, Junjie Guan, Chao Tang, Ning He, Wei Zhang, Shiping Fu
One homogeneous polysaccharide (ZWP) was successfully isolated and purified from the rhizomes of Curcuma zedoaria and the aim of present study was to determine the potential of chitosan/silk hydrogel sponge loaded with platelet-rich plasma exosomes (PRP-Exos), ZWP or PRP-Exos/ZWP on wound-healing in diabetic rats. An in vivo diabetic wound healing study showed that separate or combined treatments all resulted in a wound contraction in diabetic rats, as evidenced by a decrease of ulcer and an increase of epidermal thickness, but PRP-Exos/ZWP combination therapy was more successful in wound closing than either PRP-Exos or ZWP single administration...
May 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29760691/extracellular-vesicle-heterogeneity-subpopulations-isolation-techniques-and-diverse-functions-in-cancer-progression
#3
REVIEW
Eduard Willms, Carlos Cabañas, Imre Mäger, Matthew J A Wood, Pieter Vader
Cells release membrane enclosed nano-sized vesicles termed extracellular vesicles (EVs) that function as mediators of intercellular communication by transferring biological information between cells. Tumor-derived EVs have emerged as important mediators in cancer development and progression, mainly through transfer of their bioactive content which can include oncoproteins, oncogenes, chemokine receptors, as well as soluble factors, transcripts of proteins and miRNAs involved in angiogenesis or inflammation...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29744805/regenerative-therapy-for-cardiomyopathies
#4
Zi Wang, Xuan Su, Muhammad Ashraf, Il-Man Kim, Neal L Weintraub, Meng Jiang, Yaoliang Tang
Despite substantial advances in the development of medical and interventional strategies in ischemic and non-ischemic heart diseases, cardiovascular diseases (CVDs) remain the leading cause of mortality and morbidity worldwide. Stem cell therapy for heart disease has gained traction over the past two decades and is an emerging option for the treatment of myocardial dysfunction. In this review, we summarize the current literature on different types of stem cells and their potential usage in ischemic and non-ischemic heart diseases...
May 9, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29721064/coronary-serum-exosomes-derived-from-patients-with-myocardial-ischemia-regulate-angiogenesis-through-the-mir-939-mediated-nitric-oxide-signaling-pathway
#5
Hao Li, Yiteng Liao, Lei Gao, Tao Zhuang, Zheyong Huang, Hongming Zhu, Junbo Ge
Rationale: Angiogenesis is a crucial step towards tissue repair and regeneration after ischemia. The role of circulating exosomes in angiogenic signal transduction has not been well elucidated. Thus, this study aims to investigate the effects of coronary serum exosomes from patients with myocardial ischemia on angiogenesis and to elucidate the underlying mechanisms. Methods and Results: The patients were enrolled according to the inclusion and exclusion criteria. Coronary blood was obtained from the angiography catheter...
2018: Theranostics
https://www.readbyqxmd.com/read/29714636/extracellular-vesicles-released-in-response-to-respiratory-exposures-implications-for-chronic-disease
#6
Birke J Benedikter, Emiel F M Wouters, Paul H M Savelkoul, Gernot G U Rohde, Frank R M Stassen
Extracellular vesicles (EV) are secreted signaling entities that enhance various pathological processes when released in response to cellular stresses. Respiratory exposures such as cigarette smoke and air pollution exert cellular stresses and are associated with an increased risk of several chronic diseases. The aim of this review was to examine the evidence that modifications in EV contribute to respiratory exposure-associated diseases. Publications were searched using PubMed and Google Scholar with the search terms (cigarette smoke OR tobacco smoke OR air pollution OR particulate matter) AND (extracellular vesicles OR exosomes OR microvesicles OR microparticles OR ectosomes)...
May 1, 2018: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
https://www.readbyqxmd.com/read/29713019/imaging-of-angiogenesis-of-human-umbilical-vein-endothelial-cells-by-uptake-of-exosomes-secreted-from-hepatocellular-carcinoma-cells
#7
Hiroshi Yukawa, Kaoru Suzuki, Keita Aoki, Tomoko Arimoto, Takao Yasui, Noritada Kaji, Tetsuya Ishikawa, Takahiro Ochiya, Yoshinobu Baba
Hepatocellular carcinoma (HCC) is a typical hyper-vascular tumor, so the understanding the mechanisms of angiogenesis in HCC is very important for its treatment. However, the influence of the exosomes secreted from HCC cells (HCC-exosomes) on angiogenesis remains poorly understood. We herein examined the effects of the exosomes secreted from HepG2 cells (HepG2-exosomes) on the lumen formation of human umbilical vein endothelial cells (HUVECs) by the imaging of angiogenesis. The degree of lumen formation of HUVECs was dependent on the number of HepG2-exosomes...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29705934/exosomes-secreted-by-adipose-derived-stem-cells-contribute-to-angiogenesis-of-brain-microvascular-endothelial-cells-following-oxygen-glucose-deprivation-in-vitro-through-microrna-181b-trpm7-axis
#8
Yujia Yang, Yue Cai, Yuan Zhang, Juan Liu, Zhiqiang Xu
Adipose-derived stem cells (ADSCs) have been demonstrated to promote cerebral vascular remodeling processes after stroke. However, the exact molecular mechanism by which ADSCs exert protective roles in ischemic stroke is still poorly understood. In this study, we identified the role of exosomal microRNA-181b-5p (181b-Exos) in regulating post-stroke angiogenesis. The results of migration assay and capillary network formation assay showed that exosomes secreted by ADSCs (ADSCs-Exos) promoted the mobility and angiogenesis of brain microvascular endothelial cells (BMECs) after oxygen-glucose deprivation (OGD)...
April 29, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29703238/integrins-as-therapeutic-targets-in-the-organ-specific-metastasis-of-human-malignant-melanoma
#9
REVIEW
Ruixia Huang, Einar K Rofstad
Integrins are a large family of adhesion molecules that mediate cell-cell and cell-extracellular matrix interactions. Among the 24 integrin isoforms, many have been found to be associated with tumor angiogenesis, tumor cell migration and proliferation, and metastasis. Integrins, especially αvβ3, αvβ5 and α5β1, participate in mediating tumor angiogenesis by interacting with the vascular endothelial growth factor and angiopoietin-Tie signaling pathways. Melanoma patients have a poor prognosis when the primary tumor has generated distant metastases, and the melanoma metastatic site is an independent predictor of the survival of these patients...
April 27, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29698635/exosomal-mir-21a-5p-mediates-cardioprotection-by-mesenchymal-stem-cells
#10
Kristin M Luther, Lauren Haar, Myc McGuinness, Yang Wang, Tom Lynch, Anh Phan, Yang Song, Zilong Shen, George Gardner, Gina Kuffel, Xiaoping Ren, Michael J Zilliox, W Keith Jones
Though experimental, stem cell transplantation has the potential to improve the condition of the heart after myocardial infarction. It does so by reducing infarct size and inducing repair of heart muscle and its blood supply. Mesenchymal stem cells (MSC) have been found to be effective in pre-clinical animal models and clinical trials, but the mechanisms by which they induce cardioprotection and repair are still not fully understood. Small extracellular vesicles known as exosomes are now recognized to be key mediators of beneficial MSC paracrine effects, and the concept that they transfer miRNA to change gene expression in recipient cells is of current therapeutic interest...
April 23, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29687628/proteomic-profiling-exosomes-from-vascular-smooth-muscle-cell
#11
Hong Qiu, Songshan Shi, Shunchun Wang, Hong Peng, Shi-Jian Ding, Lianchun Wang
PURPOSE: Vascular smooth muscle cells (VSMC) and endothelial cells (EC) communicate mutually to coordinate vascular development and homeostasis. Exosomes are emerging as one type of the mediators involved in this communication. Characterizing proteins in the exosomes is the critical first step in understanding how the VSMC-EC crosstalk is mediated by exosomes. EXPERIMENTAL DESIGN: We profiled the proteins in the human VSMC-derived exosomes using nanoLC-MS/MS based proteomics...
April 24, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29685689/insulin-resistance-adipocyte-derived-exosomes-aggravate-atherosclerosis-by-increasing-vasa-vasorum-angiogenesis-in-diabetic-apoe-mice
#12
Feng Wang, Fang-Fang Chen, Yuan-Yuan Shang, Ya Li, Zhi-Hao Wang, Lu Han, Yi-Hui Li, Lei Zhang, Yun Ti, Wei Zhang, Ming Zhong
BACKGROUND: Vasa vasorum (VV) angiogenesis is increased in type 2 diabetes mellitus (T2DM) and may promote atherosclerotic plaque rupture. We sought to determine whether insulin resistance adipocyte-derived exosomes (IRADEs) played a major role in modulating VV angiogenesis and the mechanisms involved. METHODS: The characterization of IRADEs was performed by electron microscopy, NTA (Nanoparticle Tracking Analysis) and western blot. The cellular effects of IRADEs on angiogenesis were explored in human umbilical vein endothelial cells (HUVECs) and murine aortic endothelial cells (MAECs) in vitro...
April 9, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29684038/murine-embryos-exposed-to-human-endometrial-mscs-derived-extracellular-vesicles-exhibit-higher-vegf-pdgf-aa-release-increased-blastomere-count-and-hatching-rates
#13
Rebeca Blázquez, Francisco Miguel Sánchez-Margallo, Verónica Álvarez, Elvira Matilla, Nuria Hernández, Federica Marinaro, María Gómez-Serrano, Inmaculada Jorge, Javier G Casado, Beatriz Macías-García
Endometrial Mesenchymal Stromal Cells (endMSCs) are multipotent cells with immunomodulatory and pro-regenerative activity which is mainly mediated by a paracrine effect. The exosomes released by MSCs have become a promising therapeutic tool for the treatment of immune-mediated diseases. More specifically, extracellular vesicles derived from endMSCs (EV-endMSCs) have demonstrated a cardioprotective effect through the release of anti-apoptotic and pro-angiogenic factors. Here we hypothesize that EV-endMSCs may be used as a co-adjuvant to improve in vitro fertilization outcomes and embryo quality...
2018: PloS One
https://www.readbyqxmd.com/read/29672851/human-hepatocellular-carcinoma-protection-by-melatonin
#14
REVIEW
Keywan Mortezaee
Despite great scientific breakthroughs toward understanding the identity of human hepatocellular carcinoma (HCC) mechanistically, there are still no clinically efficient therapeutic methods for this cancer. Melatonin (N-acetyl-5-methoxytryptamine) is a multi-tasking hormone that has long been known for its anti-cancer activity against various human cancers including HCC, which is a focus of this review. PubMed database was searched for relevant articles with the keywords: hepatocellular carcinoma (HCC), melatonin, apoptosis, proliferation, invasion, angiogenesis, autophagy, oxidative stress, tumor immunity, and mitogen-activated protein kinase (MAPK) focusing on just human cell lines and English language articles...
April 19, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29667069/the-versatile-role-of-exosomes-in-cancer-progression-diagnostic-and-therapeutic-implications
#15
REVIEW
Vignesh Sundararajan, Fazlul H Sarkar, Thamil Selvee Ramasamy
BACKGROUND: Recent advances in cancer biology have highlighted the relevance of exosomes and nanovesicles as carriers of genetic and biological messages between cancer cells and their immediate and/or distant environments. It has been found that these molecular cues may play significant roles in cancer progression and metastasis. Cancer cells secrete exosomes containing diverse molecules that can be transferred to recipient cells and/or vice versa to induce a plethora of biological processes, including angiogenesis, metastasis formation, therapeutic resistance, epithelial-mesenchymal transition and epigenetic/stemness (re)programming...
April 17, 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29651102/exosomes-from-adipose-derived-stem-cells-overexpressing-nrf2-accelerate-cutaneous-wound-healing-by-promoting-vascularization-in-a-diabetic-foot-ulcer-rat-model
#16
Xue Li, Xiaoyun Xie, Weishuai Lian, Rongfeng Shi, Shilong Han, Haijun Zhang, Ligong Lu, Maoquan Li
Diabetic foot ulcers (DFU) increase the risks of infection and amputation in patients with diabetes mellitus (DM). The impaired function and senescence of endothelial progenitor cells (EPCs) and high glucose-induced ROS likely exacerbate DFUs. We assessed EPCs in 60 patients with DM in a hospital or primary care setting. We also evaluated the therapeutic effects of exosomes secreted from adipose-derived stem cells (ADSCs) on stress-mediated senescence of EPCs induced by high glucose. Additionally, the effects of exosomes and Nrf2 overexpression in ADSCs were investigated in vitro and in vivo in a diabetic rat model...
April 13, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29623851/mesenchymal-stem-cells-derived-exosomes-a-possible-therapeutic-strategy-for-osteoporosis
#17
Yue Li, Daxiang Jin, Weixing Xie, Longfei Wen, Weijian Chen, Jixi Xu, Jinyong Ding, Dongcheng Ren, Zenglin Xiao
Osteoporosis is a common age-related disorder characterized by low bone mass and deterioration in bone microarchitecture, leading to increased skeletal fragility and fracture risk. The pathophysiology of osteoporosis is multifactorial. It is related to the imbalance between osteoblasts and osteoclasts; reduced bone mass and increased adipogenesis in the bone marrow. Moreover, angiogenesis, inflammatory process and miRNAs have shown effects in the formation of osteoporosis. In the recent years, mesenchymal stem cells (MSCs) have been regarded as an excellent choice for cell-based tissue engineering therapy of osteoporosis...
April 3, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29621777/loading-mir-210-in-endothelial-progenitor-cells-derived-exosomes-boosts-their-beneficial-effects-on-hypoxia-reoxygeneation-injured-human-endothelial-cells-via-protecting-mitochondrial-function
#18
Xiaotang Ma, Jinju Wang, Jiao Li, Chunlian Ma, Shuzhen Chen, Wei Lei, Yi Yang, Shiming Liu, Ji Bihl, Can Chen
BACKGROUND/AIMS: Stem cell-derived exosomes (EXs) offer protective effects on various cells via their carried microRNAs (miRs). Meanwhile, miR-210 has been shown to reduce mitochondrial reactive oxygen species (ROS) overproduction. In this study, we determined the potential effects of endothelial progenitor cell-derived EXs (EPC-EXs) on hypoxia/ reoxygenation (H/R) injured endothelial cells (ECs) and investigated whether these effects could be boosted by miR-210 loading. METHODS: Human EPCs were used to generate EPC-EXs, or transfected with scrambler control or miR-210 mimics to generate EPC-EXssc and EPC-EXsmiR-210...
March 29, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29616188/the-origin-and-functions-of-exosomes-in-cancer
#19
REVIEW
Chitra Rajagopal, K B Harikumar
Exosomes are nanovesicles having a maximum size of 150 nm and is a newly emerging focus in various fields of research. Its role in cargo trafficking along with its differential expression is associated with the disrupted homeostasis and provides an opportunity to defend against different diseases like cancer. Furthermore, exosomes are rich in cargos, which contain proteins and nucleic acids that directly reflect the metabolic state of the cells from which it originates. This review summarizes recent studies on tumor-derived exosomes with an overview about biogenesis, their functions and potential of using as diagnostic and prognostic markers...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29611751/-the-pathogenetic-role-and-expression-profile-of-micrornas-in-preeclampsia
#20
Orsolya Biró, János Rigó
Preeclampsia is the leading cause of maternal and fetal morbidity and mortality that affects 3-8% of pregnancies worldwide. Its main symptoms include new onset of high blood pressure and proteinuria after 20 weeks of pregnancy. The cause of the disease is still debated. microRNAs are short, non-coding RNA molecules that play a pivotal part in the posttranscriptional regulation of eukaryotic genes. They are involved in fine-tuning of vital physiological processes such as cell cycle, proliferation, differentiation and cell death...
April 2018: Orvosi Hetilap
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