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Arginine vasopressin

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https://www.readbyqxmd.com/read/29472379/diagnosis-of-endocrine-disease-the-role-of-the-desmopressin-test-in-the-diagnosis-and-follow-up-of-cushing-s-syndrome
#1
Dimitra Argyro Vassiliadi, Stylianos Tsagarakis
Desmopressin is a vasopressin analogue selective for type 2 vasopressin receptors that mediate renal water retention. In contrast to the native hormone arginine-vasopressin, a well-known ACTH secretagogue, desmopressin exerts minimal or no activity on ACTH excretion. However, in a substantial proportion of patients with ACTH-dependent Cushing's syndrome (CS), desmopressin elicits an ACTH and cortisol response, which contrasts with the minimal responses obtained in healthy subjects. The mechanism underlying this paradoxical response involves upregulation of vasopressin type 3 and/or the aberrant expression of type 2 receptors by neoplastic ACTH-producing cells...
February 22, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29464737/copeptin-role-in-polyuria-polydipsia-syndrome-pps-differential-diagnosis-and-reference-range-in-paediatric-age
#2
Gerdi Tuli, Daniele Tessaris, Silvia Einaudi, Patrizia Matarazzo, Luisa de Sanctis
OBJECTIVE: Plasma arginine-vasopressin (AVP) analysis can help in the differential diagnosis of the polyuria-polydipsia syndrome (PPS), even if such investigation is hampered by technical difficulties, conversely to its surrogate copeptin. This study aims to enlarge the existing data on normal copeptin levels in childhood, to evaluate the correlation between copeptin, serum sodium and plasma and urine osmolality, and to assess the utility of the copeptin analysis in the diagnostic work-up of PPS in the paediatric age...
February 21, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29446159/arginine-vasopressin-differentially-modulates-gabaergic-synaptic-transmission-onto-temperature-sensitive-and-insensitive-neurons-in-the-rat-preoptic-area
#3
Yu Tang, Yan-Ni Sun, Run Xu, Xiao Huang, Shuang Gu, Cheng-Cheng Hong, Mi-Jia Liu, Heng Jiang, Yong-Lu Yang, Jing Shi
The preoptic area (POA) of the hypothalamus, containing temperature-sensitive and -insensitive neurons, plays a key role in specific thermoregulatory responses. Although arginine vasopressin (AVP) has been shown to induce hypothermia by increasing the firing activities of warm-sensitive neurons and decreasing those of cold-sensitive and temperature-insensitive neurons, the effects of AVP on POA GABAergic transmission remain unknown. Herein, inhibitory postsynaptic currents (IPSCs) of temperature-sensitive and temperature-insensitive neurons in POA slices were recorded using whole-cell patch clamp...
February 15, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29436285/m%C3%A3-ni%C3%A3-re-s-disease-pathophysiology-endolymphatic-sac-immunohistochemical-study-of-aquaporin-2-v2r-vasopressin-receptor-nkcc2-and-trpv4
#4
Marc-Henri Asmar, Louis Gaboury, Issam Saliba
Objectives Endolymphatic sac (ELS) pathophysiology in Ménière's disease (MD) remains poorly understood. We identified from the literature a group of proteins expressed on the ELS and involved in endolymph volume regulation: aquaporin-2 (AQP2), vasopressin receptor V2R, sodium potassium chloride cotransporter 2 (NKCC2), and transient receptor potential cation channel V4 (TRPV4). Our objective was to determine whether their ELS expression was altered in MD, to better understand the pathophysiology of endolymphatic hydrops...
February 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29428027/does-vasopressin-exacerbate-cerebral-edema-in-patients-with-severe-traumatic-brain-injury
#5
Casey J Allen, Ty K Subhawong, Mena M Hanna, Lydia Chelala, M Ross Bullock, Carl I Schulman, Kenneth G Proctor
Arginine vasopressin (AVP) is often used as an alternative pressor to catecholamines (CATs). However, unlike CATs, AVP is a powerful antidiuretic that could promote edema. We tested the hypothesis that AVP promoted cerebral edema and/or increased requirements for osmotherapy, relative to those who received CATs, for cerebral perfusion pressure (CPP) management after traumatic brain injury (TBI). This is a retrospective review of 286 consecutive TBI patients with intracranial pressure monitoring at a single institution from September 2008 to January 2015...
January 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29422070/copeptin-levels-and-commonly-used-laboratory-parameters-in-hospitalised-patients-with-severe-hypernatraemia-the-co-med-study
#6
Nicole Nigro, Bettina Winzeler, Isabelle Suter-Widmer, Philipp Schuetz, Birsen Arici, Martina Bally, Julie Refardt, Matthias Betz, Gani Gashi, Sandrine A Urwyler, Lukas Burget, Claudine A Blum, Andreas Bock, Andreas Huber, Beat Müller, Mirjam Christ-Crain
BACKGROUND: Hypernatraemia is common in inpatients and is associated with substantial morbidity. Its differential diagnosis is challenging, and delayed treatment may have devastating consequences. The most important hormone for the regulation of water homeostasis is arginine vasopressin, and copeptin, the C-terminal portion of the precursor peptide of arginine vasopressin, might be a reliable new parameter with which to assess the underlying cause of hypernatraemia. METHODS: In this prospective, multicentre, observational study conducted in two tertiary referral centres in Switzerland, 92 patients with severe hyperosmolar hypernatraemia (Na + > 155 mmol/L) were included...
February 9, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29406581/crf2-receptor-deficiency-eliminates-social-behaviour-deficits-and-vulnerability-induced-by-cocaine
#7
Nadège Morisot, Romain Monier, Catherine Le Moine, Mark J Millan, Angelo Contarino
BACKGROUND AND PURPOSE: Poor social behaviour and vulnerability to stress are major clinical features of stimulant use disorders. The corticotropin-releasing factor (CRF) system mediates stress responses and might underlie substance use disorders; however, its implication in social impairment induced by stimulant substances remains unknown. CRF signalling is mediated by two receptor types, CRF1 and CRF2 . The present study investigated the role for the CRF2 receptor in social behaviour deficits, vulnerability to stress and related brain alterations induced by cocaine administration and withdrawal...
February 6, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29403366/status-dependent-vasotocin-modulation-of-dominance-and-subordination-in-the-weakly-electric-fish-gymnotus-omarorum
#8
Rossana Perrone, Ana C Silva
Dominant-subordinate status emerges from agonistic encounters. The weakly electric fish, Gymnotus omarorum, displays a clear-cut example of non-breeding territorial aggression. The asymmetry in the behavior of dominants and subordinates is outstanding. Dominants are highly aggressive and subordinates signal submission in a precise sequence of locomotor and electric traits: retreating, decreasing their electric organ discharge rate, and emitting transient electric signals. The hypothalamic neuropeptide arginine-vasotocin (AVT) and its mammalian homolog arginine-vasopressin, are key modulators of social behavior, known to adapt their actions to different contexts...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29403357/surge-of-peripheral-arginine-vasopressin-in-a-rat-model-of-birth-asphyxia
#9
Milla Summanen, Susanne Bäck, Juha Voipio, Kai Kaila
Mammalian birth is accompanied by a period of obligatory asphyxia, which consists of hypoxia (drop in blood O2 levels) and hypercapnia (elevation of blood CO2 levels). Prolonged, complicated birth can extend the asphyxic period, leading to a pathophysiological situation, and in humans, to the diagnosis of clinical birth asphyxia, the main cause of hypoxic-ischemic encephalopathy (HIE). The neuroendocrine component of birth asphyxia, in particular the increase in circulating levels of arginine vasopressin (AVP), has been extensively studied in humans...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29394883/contiguous-22-1-kb-deletion-embracing-avpr2-and-arhgap4-genes-at-novel-breakpoints-leads-to-nephrogenic-diabetes-insipidus-in-a-chinese-pedigree
#10
Ying Bai, Yibing Chen, Xiangdong Kong
BACKGROUND: It has been reported that mutations in arginine vasopressin type 2 receptor (AVPR2) cause congenital X-linked nephrogenic diabetes insipidus (NDI). However, only a few cases of AVPR2 deletion have been documented in China. METHODS: An NDI pedigree was included in this study, including the proband and his mother. All NDI patients had polyuria, polydipsia, and growth retardation. PCR mapping, long range PCR and sanger sequencing were used to identify genetic causes of NDI...
February 2, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29386406/identification-and-functional-characterization-of-arginine-vasopressin-receptor-1a-atypical-chemokine-receptor-3-heteromers-in-vascular-smooth-muscle
#11
Lauren J Albee, Heather M LaPorte, Xianlong Gao, Jonathan M Eby, You-Hong Cheng, Amanda M Nevins, Brian F Volkman, Vadim Gaponenko, Matthias Majetschak
Recent observations suggest that atypical chemokine receptor (ACKR)3 and chemokine (C-X-C motif) receptor (CXCR)4 regulate human vascular smooth muscle function through hetero-oligomerization with α1-adrenoceptors. Here, we show that ACKR3 also regulates arginine vasopressin receptor (AVPR)1A. We observed that ACKR3 agonists inhibit arginine vasopressin (aVP)-induced inositol trisphosphate (IP3) production in human vascular smooth muscle cells (hVSMCs) and antagonize aVP-mediated constriction of isolated arteries...
January 2018: Open Biology
https://www.readbyqxmd.com/read/29386227/role-of-11%C3%AE-hsd-type-1-in-abnormal-hpa-axis-activity-during-immune-mediated-arthritis
#12
Janko Sattler, Jinwen Tu, Shihani Stoner, Jingbao Li, Frank Buttgereit, Markus Seibel, Hong Zhou, Mark S Cooper
Patients with chronic immune-mediated arthritis exhibit abnormal hypothalamo-pituitary-adrenal (HPA) axis activity. The basis for this abnormality is not known. Immune-mediated arthritis is associated with increased extra-adrenal synthesis of active glucocorticoids by the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme. 11β-HSD1 is expressed in the central nervous system, including regions involved in HPA axis regulation. We examined whether altered 11β-HSD1 expression within these regions contributes to HPA axis dysregulation during arthritis...
January 31, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29383758/circadian-expression-and-functional-characterization-of-pea-15-within-the-mouse-suprachiasmatic-nucleus
#13
Kelin Wheaton, Sydney Aten, Lucas Sales Queiroz, Kyle Sullivan, John Oberdick, Kari R Hoyt, Karl Obrietan
The circadian timing system influences the functional properties of most, if not all, physiological processes. Central to the mammalian timing system is the suprachiasmatic nucleus (SCN) of the hypothalamus. The SCN functions as a 'master clock' that sets the phasing of ancillary circadian oscillator populations found throughout the body. Further, via an entraining input from the retina, the SCN ensures that the clock oscillators are synchronized to the daily light/dark cycle. A critical component of the SCN timing and entrainment systems is the p44/42 mitogen-activated protein kinase (ERK/MAPK) pathway...
January 31, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29378555/the-clinical-course-and-pathophysiological-investigation-of-adolescent-gestational-diabetes-insipidus-a-case-report
#14
Tatsuya Kondo, Miwa Nakamura, Sayaka Kitano, Junji Kawashima, Takeshi Matsumura, Takashi Ohba, Munekage Yamaguchi, Hidetaka Katabuchi, Eiichi Araki
BACKGROUND: Gestational diabetes insipidus (GDI) is a rare endocrine complication during pregnancy that is associated with vasopressinase overproduction from the placenta. Although increased vasopressinase is associated with placental volume, the regulation of placental growth in the later stage of pregnancy is not well known. CASE PRESENTATION: A 16-year-old pregnant woman was urgently transferred to our hospital because of threatened premature labor when the Kumamoto earthquakes hit the area where she lived...
January 30, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29378356/a-mechanistic-model-to-quantify-von-willebrand-factor-release-survival-and-proteolysis-in-patients-with-von-willebrand-disease
#15
Myriam Ferrari, Federico Galvanin, Massimiliano Barolo, Viviana Daidone, Roberto Padrini, Fabrizio Bezzo, Alessandra Casonato
A reduced von Willebrand factor (VWF) synthesis or survival, or its increased proteolysis, alone or in combination, contributes to the development of von Willebrand disease (VWD).We describe a new, simple mechanistic model for exploring how VWF behaves in well-defined forms of VWD after its 1-desamino-8-D-arginine vasopressin (DDAVP)-induced release from endothelial cells. We aimed to ascertain whether the model can consistently predict VWF kinetic changes. The study involved 9 patients with VWD types Vicenza (a paradigmatic form with a reduced VWF survival), 8 type 2B, 2 type 2A-I, 1 type 2A-II (associated with an increased VWF proteolysis), and 42 normal controls, whose VWF levels were measured after a 24-hour-long DDAVP test...
February 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29377134/critical-role-of-rabphilin-3a-in-the-pathophysiology-of-experimental-lymphocytic-neurohypophysitis
#16
Yoshinori Yasuda, Shintaro Iwama, Atsushi Kiyota, Hisakazu Izumida, Kohtaro Nakashima, Naoko Iwata, Yoshihiro Ito, Yoshiaki Morishita, Motomitsu Goto, Hidetaka Suga, Ryoichi Banno, Atsushi Enomoto, Masahide Takahashi, Hiroshi Arima, Yoshihisa Sugimura
Autoimmune hypophysitis (AH) is thought to be an autoimmune disease characterized by lymphocytic infiltration of the pituitary gland. Among AH pathologies, lymphocytic infundibulo-neurohypophysitis (LINH) represents infiltration of the neurohypophysis and/or the hypothalamic infundibulum, causing central diabetes insipidus due to insufficiency of arginine vasopressin (AVP) secretion. The pathophysiological and pathogenetic mechanisms underlying LINH are largely unknown. Clinically, differentiating LINH from other pituitary diseases accompanied by mass lesions, including tumors, has been often difficult because of similar clinical manifestations...
January 29, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29373579/an-akap-lbc-rhoa-interaction-inhibitor-promotes-the-translocation-of-aquaporin-2-to-the-plasma-membrane-of-renal-collecting-duct-principal-cells
#17
Katharina Schrade, Jessica Tröger, Adeeb Eldahshan, Kerstin Zühlke, Kamal R Abdul Azeez, Jonathan M Elkins, Martin Neuenschwander, Andreas Oder, Mohamed Elkewedi, Sarah Jaksch, Karsten Andrae, Jinliang Li, Joao Fernandes, Paul Markus Müller, Stephan Grunwald, Stephen F Marino, Tanja Vukićević, Jenny Eichhorst, Burkhard Wiesner, Marcus Weber, Michael Kapiloff, Oliver Rocks, Oliver Daumke, Thomas Wieland, Stefan Knapp, Jens Peter von Kries, Enno Klussmann
Stimulation of renal collecting duct principal cells with antidiuretic hormone (arginine-vasopressin, AVP) results in inhibition of the small GTPase RhoA and the enrichment of the water channel aquaporin-2 (AQP2) in the plasma membrane. The membrane insertion facilitates water reabsorption from primary urine and fine-tuning of body water homeostasis. Rho guanine nucleotide exchange factors (GEFs) interact with RhoA, catalyze the exchange of GDP for GTP and thereby activate the GTPase. However, GEFs involved in the control of AQP2 in renal principal cells are unknown...
2018: PloS One
https://www.readbyqxmd.com/read/29371289/elevated-vasopressin-in-pregnant-mice-induces-t-helper-subset-alterations-consistent-with-human-preeclampsia
#18
Sabrina M Scroggins, Donna A Santillan, Jenna M Lund, Jeremy A Sandgren, Lindsay K Krotz, Wendy S Hamilton, Eric J Devor, Heather A Davis, Gary L Pierce, Katherine N Gibson-Corley, Curt D Sigmund, Justin L Grobe, Mark K Santillan
The pathogenesis of preeclampsia, a hypertensive disorder of pregnancy, involves imbalanced T helper (TH) cell populations and resultant changes in pro- and anti-inflammatory cytokine release. Elevated copeptin (an inert biomarker of arginine vasopressin (AVP)), secretion precedes the development of symptoms in preeclampsia in humans, and infusion of AVP proximal to and throughout gestation is sufficient to initiate cardiovascular and renal phenotypes of preeclampsia in wild-type C57BL/6J mice. We hypothesize that AVP infusion in wild-type mice is sufficient to induce the immune changes observed in human preeclampsia...
January 25, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29367474/cullin-associated-nedd8-dissociated-protein-1-a-novel-interactor-of-rabphilin-3a-deubiquitylates-rabphilin-3a-and-regulates-arginine-vasopressin-secretion-in-pc12-cells
#19
Kohtaro Nakashima, Seiji Takeuchi, Shintaro Iwama, Atsushi Kiyota, Yoshinori Yasuda, Naoko Iwata, Atsushi Enomoto, Hiroshi Arima, Yoshihisa Sugimura
The molecular mechanism involved in the exocytosis of arginine vasopressin (AVP) is not fully known. Rabphilin-3A has been suggested as a novel autoantigen in infundibulo-neurohypophysitis (LINH), which leads to central diabetes insipidus through insufficient secretion of AVP. However, the role of rabphilin-3A in the pathogenesis of LINH remains unclear. Thus, the aim of the present study was to identify proteins binding rabphilin-3A in the posterior pituitary. Using glutathione S-transferase (GST)-pulldown assays and proteomic analyses, cullin-associated NEDD8-dissociated protein 1 (CAND1) was identified as a rabphilin-3A-binding protein in the posterior pituitary...
January 23, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29364700/angiotensin-at1a-receptors-expressed-in-vasopressin-producing-cells-of-the-supraoptic-nucleus-contribute-to-the-osmotic-control-of-vasopressin
#20
Jeremy A Sandgren, Danny W Linggonegoro, Shao Yang Zhang, Sarah A Sapouckey, Kristin E Claflin, Nicole A Pearson, Mariah R Leidinger, Gary L Pierce, Mark K Santillan, Katherine N Gibson-Corley, Curt D Sigmund, Justin L Grobe
Angiotensin II (ANG) stimulates the release of arginine vasopressin (AVP) from the neurohypophysis through activation of AT1 receptors within the brain, though it remains unclear whether AT1 receptors expressed on AVP-expressing neurons directly mediate this control. We explored the hypothesis that ANG acts through AT1A receptors expressed directly upon AVP-producing cells to regulate AVP secretion. In-situ hybridization and transgenic mice demonstrated localization of AVP and AT1A mRNA in the supraoptic nucleus (SON) and the paraventricular nucleus (PVN), but co-expression of both AVP and AT1A mRNA was only observed in the SON...
January 24, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
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