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Arginine vasopressin

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https://www.readbyqxmd.com/read/29669731/involvement-of-activated-brain-stress-responsive-systems-in-excessive-and-relapse-alcohol-drinking-in-rodent-models-implications-for-therapeutics
#1
Yan Zhou, Mary Jeanne Kreek
Addictive diseases, including addiction to alcohol pose massive public health costs. Addiction is a chronic relapsing disease, caused by both the direct effects induced by drugs and persistent neuroadaptations at several (molecular, cellular and behavioral) levels. These drug-type specific neuro-adaptations are brought on largely by the reinforcing effects of drugs on the central nervous system and environment, including stress. Results from animal experiments have demonstrated important interactions between alcohol and the stress responsive systems...
April 18, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29668014/oxytocin-and-arginine-vasopressin-systems-in-the-domestication-process
#2
Bibiana S O Fam, Pamela Paré, Aline B Felkl, Pedro Vargas-Pinilla, Vanessa R Paixão-Côrtes, Lucas Henriques Viscardi, Maria Cátira Bortolini
Domestication is of unquestionable importance to the technological revolution that has given rise to modern human societies. In this study, we analyzed the DNA and protein sequences of six genes of the oxytocin and arginine vasopressin systems (OXT-OXTR; AVP-AVPR1a, AVPR1b and AVPR2) in 40 placental mammals. These systems play an important role in the control of physiology and behavior. According to our analyses, neutrality does not explain the pattern of molecular evolution found in some of these genes. We observed specific sites under positive selection in AVPR1b (ω = 1...
2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29665969/copeptin-plasma-levels-are-associated-with-decline-of-renal-function-in-patients-with-type-2-diabetes-mellitus
#3
Maria De La Luz Villela-Torres, Ana Edith Higareda-Mendoza, Anel Gómez-García, Alfonso Rafael Alvarez-Paredes, Elvia García-López, Peter Stenvikel, Harvest F Gu, Abbul Rashid-Qureshi, Bengt Lindholm, Cleto Alvarez-Aguilar
BACKGROUND: Chronic kidney disease (CKD) is a leading complication of type 2 diabetes mellitus (T2DM) and is considered as a public health problem. Copeptin is a surrogate marker of arginine vasopressin (AVP) system and is proposed as a biomarker of decline renal function. OBJECTIVE: Evaluate whether plasma copeptin levels may be used as a biomarker of decline renal function in patients with T2DM. RESEARCH DESIGN AND METHODS: A total of 480 patients with T2DM and different stages of CKD were included...
April 14, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29665203/tolvaptan-alleviates-excessive-fluid-retention-of-nephrotic-diabetic-renal-failure-unresponsive-to-furosemide
#4
Tesshu Takada, Tsuguto Masaki, Ayako Hoshiyama, Takuya Toki, Yuji Kamata, Masayoshi Shichiri
Patients with diabetic nephropathy develop nephrotic syndrome, and may show limited response to conventional therapy. They often require earlier initiation of renal replacement therapy because they become refractory to diuretics, and experience excessive fluid retention. We aimed to investigate the efficacy of tolvaptan, an oral arginine vasopressin type 2 receptor antagonist, in a case series of 14 severe diabetic renal failure patients who were severely refractory to maximal doses of furosemide and had excessive fluid retention despite preserved cardiac function and residual renal function...
April 17, 2018: Nephrology
https://www.readbyqxmd.com/read/29627986/bacterial-cellulose-relieves-diphenoxylate-induced-constipation-in-rats
#5
Xichuan Zhai, Dehui Lin, Yan Zhao, Xingbin Yang
This study was to probe the effects of bacterial cellulose (BC) on diphenoxylate-induced constipation in rats. Administration with BC at 500 mg/kg·bw in diphenoxylate-induced constipation rats distinctly improved the carmine propulsion rate (83.5 ± 5.2%), shortened the defecating time of the first red feces (249.0 ± 23.3 min), and increased the weight of carmine red feces within 5 h (2.7 ± 1.3 g). The levels of aquaporins (AQP-2, AQP-3 and AQP-4) and inhibitory neurotransmitters (nitric oxide, nitric oxide synthetase, vasoactive intestinal peptide and arginine vasopressin) in the BC-treated groups reduced by 31...
April 7, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29627593/quantification-of-receptor-activation-by-oxytocin-and-vasopressin-in-endocytosis-coupled-bioluminescence-reduction-assay-using-nanokaz
#6
Isao Kii, Shino Hirahara-Owada, Masataka Yamaguchi, Takashi Niwa, Yuka Koike, Rie Sonamoto, Harumi Ito, Kayo Takahashi, Chihiro Yokoyama, Takuya Hayashi, Takamitsu Hosoya, Yasuyoshi Watanabe
Oxytocin (OXT) and arginine vasopressin (AVP) are structurally similar neuropeptide hormones that function as neurotransmitters in the brain, and have opposite key roles in social behaviors. These peptides bind to their G protein-coupled receptors (OXTR and AVPRs), inducing calcium ion-dependent signaling pathways and endocytosis of these receptors. Because selective agonists and antagonists for these receptors have been developed as therapeutic and diagnostic agents for diseases such as psychiatric disorders, facile methods are in demand for the evaluation of selectivity between these receptors...
April 5, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29594432/novel-and-recurrent-variants-in-avpr2-in-19-families-with-x-linked-congenital-nephrogenic-diabetes-insipidus
#7
Shivani Joshi, Helene Kvistgaard, Konstantinos Kamperis, Mia Færch, Søren Hagstrøm, Niels Gregersen, Søren Rittig, Jane Hvarregaard Christensen
Congenital nephrogenic diabetes insipidus (CNDI) is characterized by the reduced ability of renal collecting duct cells to reabsorb water in response to the antidiuretic effect of vasopressin. Chronic polyuria and polydipsia are the hallmarks of the disease. Approximately 90% of all patients with CNDI have X-linked inherited disease caused by variants in the arginine vasopressin receptor 2 (AVPR2) gene. We present genetic findings in 34 individuals from 19 kindreds including one or more family members with CNDI...
March 28, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29589487/search-of-vasopressin-analogs-with-antiproliferative-activity-on-small-cell-lung-cancer-drug-design-based-on-two-different-approaches
#8
Marina Pifano, Juan Garona, Natasha T Sobol, Marina Albertó, Daniel F Alonso, Giselle V Ripoll
AIM: Development of compounds with therapeutic application requires the interaction of different disciplines. Several tumors express vasopressin (AVP; arginine vasopressin) receptors with contrasting effects depending on receptor subtype. Desmopressin (dDAVP) is an AVP-selective analog with antiproliferative properties. In this work, an evolutionary approach and a rational strategy were applied in order to design novel AVP analogs. RESULTS: We designed two novel analogs; dDInotocin (dDINT, insect analog), and [V4 Q5 ]dDAVP, and demonstrated the importance of the dDAVP conformational loop for its antiproliferative activity...
March 28, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29581423/effects-on-gene-expression-and-behavior-of-untagged-short-tandem-repeats-the-case-of-arginine-vasopressin-receptor-1a-avpr1a-and-externalizing-behaviors
#9
Clare C Landefeld, Colin A Hodgkinson, Primavera A Spagnolo, Cheryl A Marietta, Pei-Hong Shen, Hui Sun, Zhifeng Zhou, Barbara K Lipska, David Goldman
Genome-wide association studies (GWAS) of complex, heritable, behavioral phenotypes have yielded an incomplete accounting of the genetic influences. The identified loci explain only a portion of the observed heritability, and few of the loci have been shown to be functional. It is clear that current GWAS techniques overlook key components of phenotypically relevant genetic variation, either because of sample size, as is frequently asserted, or because of methodology. Here we use arginine vasopressin receptor 1a (AVPR1a) as an in-depth model of a methodologic limitation of GWAS: the functional genetic variation (in the form of short tandem repeats) of this key gene involved in affiliative behavior cannot be captured by current GWAS methodologies...
March 27, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29578315/genes-involved-in-stress-response-influence-lithium-efficacy-in-bipolar-patients
#10
Aleksandra Szczepankiewicz, Beata Narozna, Janusz K Rybakowski, Sebastian Kliwicki, Piotr Czerski, Monika Dmitrzak-Węglarz, Maria Skibińska, Joanna Twarowska-Hauser, Joanna Pawlak
OBJECTIVES: In mood disorders, chronic stimulation with stress results in aberrant regulation of the hypothalamic-pituitary-adrenal (HPA) axis. Lithium was shown to influence HPA axis function. The underlying genetic background as well as environmental context may influence the stress response, and therefore lithium efficacy. The aim of the present study was to analyze if genetic variants located in genes involved in HPA axis regulation affect the response to long-term lithium treatment in bipolar patients...
March 26, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29575630/isosorbide-dinitrate-in-nephronophthisis-treatment
#11
Alanna Strong, Samina Muneeruddin, Richard Parrish, Daniel Lui, Susan B Conley
Nephronophthisis is a progressive disease that affects development of the renal tubules and leads to end stage renal disease. Many affected children have isolated renal disease; however, there can be additional manifestations including heart defects, liver fibrosis, brain malformations, and situs inversus. There is no way to slow or modify the disease. We describe a patient who presented at birth with cholestatic jaundice and decreased kidney function, found by exome sequencing to have two NPHP3 variants. Her clinical status deteriorated rapidly, and two disease-modifying agents were given in hopes of slowing disease progression, the arginine vasopressin type II receptor antagonist tolvaptan to stabilize her renal function and isosorbide dinitrate to manage her poorly controlled hypertension...
April 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29563233/muscarinic-m2-receptor-promotes-vasopressin-synthesis-in-mice-supraoptic-nuclei
#12
Hiroshi Nagano, Yuki Sobue, Hayato Matsuyama, Shoichiro Saito, Hiroki Sakai, Firoj Alom, Yasuyuki Tanahashi, Toshiaki Ishii, Toshihiro Unno
Muscarinic acetylcholine receptors have been suggested to be implicated in arginine-vasopressin secretion because intraventricular muscarinic agonist administration induces arginine-vasopressin release into the circulation. Although which subtype is involved in the regulation of arginine-vasopressin secretion is unclear, M2 receptors have been reported to be highly expressed in the hypothalamus. In the present study, M2 receptor knockout mice were used to elucidate whether M2 receptor regulates arginine-vasopressin synthesis in the paraventricular nuclei and supraoptic nuclei of the hypothalamus...
March 21, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29556787/dysregulation-of-the-renin-angiotensin-system-and-the-vasopressinergic-system-interactions-in-cardiovascular-disorders
#13
REVIEW
Ewa Szczepanska-Sadowska, Katarzyna Czarzasta, Agnieszka Cudnoch-Jedrzejewska
PURPOSE OF REVIEW: In many instances, the renin-angiotensin system (RAS) and the vasopressinergic system (VPS) are jointly activated by the same stimuli and engaged in the regulation of the same processes. RECENT FINDINGS: Angiotensin II (Ang II) and arginine vasopressin (AVP), which are the main active compounds of the RAS and the VPS, interact at several levels. Firstly, Ang II, acting on AT1 receptors (AT1R), plays a significant role in the release of AVP from vasopressinergic neurons and AVP, stimulating V1a receptors (V1aR), regulates the release of renin in the kidney...
March 19, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29553774/effects-of-arginine-vasopressin-on-richardson-s-ground-squirrel-social-and-vocal-behavior
#14
Angela R Freeman, James F Hare, W Gary Anderson, Heather K Caldwell
In nearly every vertebrate species examined thus far arginine vasopressin (AVP) and its homologues modulate behavior; thus, providing rich systems for comparative research. In rodents, AVP is best known for its modulation of social behavior; however, to date, research on AVPs effects on behavior have been limited to laboratory models and a few experiments using large outdoor enclosures. To extend our understanding of AVPs role in modulating social behavior and communication in an ecologically relevant context, we examined the effects of AVP on behavior of free-living Richardson's ground squirrels (Urocitellus richardsonii)...
February 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29550928/effect-of-vasopressin-induced-chronic-hyponatremia-on-the-regulation-of-the-middle-cerebral-artery-of-the-rat
#15
Marta Aleksandrowicz, Ewa Kozniewska
Vasopressin (arginine vasopressin, AVP) plays a crucial role in maintaining body fluid homeostasis. Excessive release of vasopressin can lead to hyponatremia. Changes in cerebral circulation during vasopressin-induced chronic hyponatremia are not elucidated. The present study has been designed to investigate the effect of chronic vasopressin-induced hyponatremia on the regulation of the tone of the middle cerebral artery (MCA) of the rat. Chronic hyponatremia was induced in vivo with the help of vasopressin, released continuously from subcutaneously implanted ALZET mini-osmotic pumps, and a liquid diet...
March 17, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29546600/focus-on-neonatal-and-infantile-onset-of-nephrogenic-syndrome-of-inappropriate-antidiuresis-12-years-later
#16
REVIEW
Flaminia Bardanzellu, Maria Cristina Pintus, Valentina Masile, Vassilios Fanos, Maria Antonietta Marcialis
Nephrogenic syndrome of inappropriate antidiuresis (NSIAD), first described in 2005, is a rare genetic X-linked disease, presenting with hyponatremia, hyposmolarity, euvolemia, inappropriately concentrated urine, increased natriuresis, and undetectable or very low arginine-vasopressine (AVP) circulating levels. It can occur in neonates, infants, or later in life. NSIAD must be early recognized and treated to prevent severe hyponatremia, which can show a dangerous impact on neonatal outcome. In fact, it potentially leads to death or, in case of survival, neurologic sequelae...
March 15, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29541862/do-independent-geriatric-outpatients-with-nocturnal-polyuria-profit-from-desmopressin
#17
W Weinrebe, S Käbe-Frisch, I Füsgen, M Karaman, E Johannsdottir, S Rupp
OBJECTIVE: To compare the efficacy of desmopressin and placebo in independent geriatric outpatients with nocturnal polyuria (NP). METHODS: A prospective, randomized, single-center, national, double blind, placebo-controlled, fixed-dose, parallel group comparative trial was carried out. The study included 110 geriatric outpatients, 55 patients per treatment group using desmopressin acetate nasal spray (strength: 0.1 mg/ml) once daily of 10 μg/spray blast or placebo...
March 14, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29527508/is-serum-copeptin-a-modifiable-biomarker-in-autosomal-dominant-polycystic-kidney-disease
#18
REVIEW
Moomal Tasneem, Carly Mannix, Annette Wong, Jennifer Zhang, Gopala Rangan
The availability of disease-modifying drugs for the management of autosomal dominant polycystic kidney disease (ADPKD) has accelerated the need to accurately predict renal prognosis and/or treatment response in this condition. Arginine vasopressin (AVP) is a critical determinant of postnatal kidney cyst growth in ADPKD. Copeptin (the C-terminal glycoprotein of the precursor AVP peptide) is an accurate surrogate marker of AVP release that is stable and easily measured by immunoassay. Cohort studies show that serum copeptin is correlated with disease severity in ADPKD, and predicts future renal events [decline in renal function and increase in total kidney volume (TKV)]...
March 6, 2018: World Journal of Nephrology
https://www.readbyqxmd.com/read/29503216/the-avpr1a-gene-and-its-single-nucleotide-polymorphism-rs10877969-a-literature-review-of-associations-with-health-conditions-and-pain
#19
REVIEW
Keesha L Roach, Patricia E Hershberger, Julienne N Rutherford, Robert E Molokie, Zaijie Jim Wang, Diana J Wilkie
Pain is the quintessential symptom for individuals suffering from sickle cell disease (SCD). Although the degree of suffering and the cost of treatment are staggering, SCD continues to be grossly understudied, including a lack of data for pain-related genes and prevalence of polymorphisms in this population. This lack of data adds to the inadequacy of pain therapy in this population. Pain genetics investigators have recently examined allele frequencies of single-nucleotide polymorphisms from candidate genes in people who have SCD...
March 1, 2018: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29494890/outcome-of-diabetes-insipidus-in-patients-with-rathke-s-cleft-cysts
#20
Masahiro Oishi, Yasuhiko Hayashi, Yasuo Sasagawa, Daisuke Kita, Osamu Tachibana, Mitsutoshi Nakada
OBJECTIVES: It is well-known that Rathke's cleft cysts (RCCs) infrequently cause headache, endocrinological dysfunction, and visual disturbance, and in rare cases, cause diabetes insipidus (DI). Although surgical evacuation of the cyst content can result in high rates of symptomatic improvement, not only the treatment efficacy but also the pathophysiology of DI with RCC are undetermined. The aim of this study is to elucidate the underlying mechanisms and outcomes of DI associated with RCCs...
February 21, 2018: Clinical Neurology and Neurosurgery
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