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Arginine vasopressin

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https://www.readbyqxmd.com/read/28432473/vasopressin-and-vasopressin-antagonists-in-heart-failure
#1
Julie K Vishram-Nielsen, Finn Gustafsson
Despite the introduction of multiple new pharmacological agents over the past three decades in the field of heart failure (HF), overall prognosis remains poor. Hyponatremia is prevalent in HF patients and has been suggested as a contributor to poor response to standard therapy. Elevated levels of arginine vasopressin (AVP), a peptide hormone produced in the hypothalamus, play a role in development of hyponatremia, and AVP and its surrogate, copeptin, are related to changes in osmolality, hemodynamics, neuro-hormones as well as in overall outcome in HF patients...
April 22, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28420919/association-of-arginine-vasopressin-receptor-1a-gene-polymorphisms-with-hepatorenal-syndrome
#2
Chen Wang, Zhe Yu, Xin Luo, Jianhong Ye, Shourong Liu, Liangbin Miu, Jianfeng Bao, Fei Wang
OBJECTIVE: To assess the association of arginine vasopressin receptor 1a gene single nucleotide polymorphisms with type I hepatorenal syndrome. METHODS: The case-control study was conducted at the Hangzhou City Xixi Hospital, Hangzhou, China, from January 2012 to June 2014, and comprised patients with type I hepatorenal syndrome and individuals with cirrhosis who acted as the control group. Arginine vasopressin receptor 1a gene rs113481894 locus single nucleotide polymorphisms were analysed by high-resolution melting methods...
April 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28420857/usefulness-of-anti-rabphilin-3a-antibodies-for-diagnosing-central-diabetes-insipidus-in-the-third-trimester-of-pregnancy
#3
Kanako Sakurai, Rika Yamashita, Satsuki Niituma, Shintaro Iwama, Yoshihisa Sugimura, Zenei Arihara, Kazuhiro Takahashi
We report a 27-year-old pregnant woman with polyuria, polydipsia and headache in the third trimester of pregnancy. Hypernatremia (153 mEq/L), high plasma osmolality (300 mOsm/kgH2O) and low urinary osmolality (92 mOsm/kgH2O) were observed at the admission to our hospital. Plasma arginine vasopressin (AVP) level was inappropriately low (2.2 pg/mL) compared to the high plasma osmolality. Plasma AVP responses to hypertonic-saline infusion were blunted, and her urine osmolality increased in response to desmopressin...
April 14, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28413508/comparative-evaluation-of-copeptin-and-nt-probnp-in-patients-with-severe-acute-decompensated-heart-failure-and-prediction-of-adverse-events-in-a-90-day-follow-up-period-a-prospective-clinical-observation-trial
#4
Jun Jia, Guang-Lei Chang, Shu Qin, Jia Chen, Wen-Yan He, Kai Lu, Yong Li, Dong-Ying Zhang
The present study compared the prognostic value of a marker, the C-terminal section of the arginine vasopressin prohormone (copeptin), with N-terminal B-type natriuretic peptide (NT-proBNP) in patients with severe acute decompensated heart failure. A prospective, observational cohort study was conducted in a tertiary care hospital and enrolled 129 patients with severe acute decompensated heart failure. Clinicians were blinded to investigational markers except NT-proBNP, and the study participants were followed up for 90 days...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28413003/induced-pluripotent-stem-cells-derived-from-a-patient-with-autosomal-dominant-familial-neurohypophyseal-diabetes-insipidus-caused-by-a-variant-in-the-avp-gene
#5
Lise Bols Toustrup, Yan Zhou, Helene Kvistgaard, Niels Gregersen, Søren Rittig, Lars Aagaard, Thomas Juhl Corydon, Yonglun Luo, Jane H Christensen
Autosomal dominant familial neurohypophyseal diabetes insipidus (adFNDI) is caused by variants in the arginine vasopressin (AVP) gene. Here we report the generation of induced pluripotent stem cells (iPSCs) from a 42-year-old man carrying an adFNDI causing variant in exon 1 of the AVP gene using lentivirus-mediated nuclear reprogramming. The iPSCs carried the expected variant in the AVP gene. Furthermore, the iPSCs expressed pluripotency markers; displayed in vitro differentiation potential to the three germ layers and had a normal karyotype consistent with the original fibroblasts...
March 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28400143/loss-of-predator-aversion-in-female-rats-after-toxoplasma-gondii-infection-is-not-dependent-on-ovarian-steroids
#6
Samira Abdulai-Saiku, Ajai Vyas
Toxoplasma gondii infection reduces aversion to cat odors in male rats. Relevant proximate mechanisms include interaction of gonadal testosterone and brain nonapeptide arginine-vasopressin. Both of these substrates are sexually dimorphic with preferential expression in males; suggesting either absence of behavioral change in females or mediation by analogous neuroendocrine substrates. Here we demonstrate that Toxoplasma gondii infection reduces aversion to cat odor in female rats. This change is not accompanied by altered steroid hormones; cannot be rescued by gonadal removal; and, does not depend on arginine-vasopressin...
April 9, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28385526/sex-difference-in-mouse-hypothalamic-transcriptome-profile-in-stress-induced-depression-model
#7
Bhanu Chandra Karisetty, Nitin Khandelwal, Arvind Kumar, Sumana Chakravarty
The influence of sex on prevalence and presentation of human depression necessitates studying its role in depression. Additionally, stress can also affect the incidence and progression of depressive phenotypes. Hypothalamus is a well-reported sexually dimorphic brain region. Hence, we performed a gene-array to uncover the chronic stress-induced transcriptional changes in the hypothalamus of male, intact female (with ovaries) and ovariectomized female mice. Chronic variable mild stress model was used to induce depression-like behavior in mice, assessed by despair behavior in forced swim test...
May 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28383092/effects-of-arginine-vasopressin-and-v1-receptor-antagonist-on-cerebral-vasospasm-secondary-to-subarachnoid-hemorrhage-an-experimental-study
#8
Derviş Mansuri Yilmaz, Ersin Haciyakupoğlu, Serkan Diril, Leman Sencar, Erol Akgül, Sait Polat, Sebahattin Haciyakupoğlu, Ersin Nazlican
AIM: The aim of this study is to examine morphological, radiological and biochemical effects of arginine vasopressin(AV) and AV V1 receptor antagonist cerebral vasospasm(CVS) in rabbit subarachnoid hemorrhage(SAH). MATERIAL AND METHODS: Forty male New Zealand white rabbits were randomly divided to four groups comprising 10 rabbits each. The groups were 1) control, 2) subarachnoid hemorrhage(SAH), 3) SAH+AV application, 4) SAH+V1 antagonist of AV V1 receptor Diameters of the basilar artery of all the groups were measured on angiograms...
March 9, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28377630/katp-channels-mediate-differential-metabolic-responses-to-glucose-shortage-of-the-dorsomedial-and-ventrolateral-oscillators-in-the-central-clock
#9
Jyh-Jeen Yang, Ruo-Ciao Cheng, Pi-Cheng Cheng, Yi-Chi Wang, Rong-Chi Huang
The suprachiasmatic nucleus (SCN) central clock comprises two coupled oscillators, with light entraining the retinorecipient vasoactive intestinal peptide (VIP)-positive ventrolateral oscillator, which then entrains the arginine vasopressin (AVP)-positive dorsomedial oscillator. While glucose availability is known to alter photic entrainment, it is unclear how the SCN neurones respond to metabolic regulation and whether the two oscillators respond differently. Here we show that the ATP-sensitive K(+) (KATP) channel mediates differential responses to glucose shortage of the two oscillators...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28374851/claudin-expression-in-the-rat-endolymphatic-duct-and-sac-first-insights-into-regulation-of-the-paracellular-barrier-by-vasopressin
#10
Daniel Runggaldier, Lidia Garcia Pradas, Peter H Neckel, Andreas F Mack, Bernhard Hirt, Corinna Gleiser
Hearing and balance functions of the inner ear rely on the homeostasis of the endolymphatic fluid. When disturbed, pathologic endolymphatic hydrops evolves as observed in Menière's disease. The molecular basis of inner ear fluid regulation across the endolymphatic epithelium is largely unknown. In this study we identified the specific expression of the tight junction (TJ) molecules Claudin 3, 4, 6, 7, 8, 10, and 16 in epithelial preparations of the rat inner ear endolymphatic duct (ED) and endolymphatic sac (ES) by high-throughput qPCR and immunofluorescence confocal microscopy...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28371737/place-preferences-associated-with-pups-or-cocaine-change-the-expression-of-d2r-v1ar-and-otr-in-the-nacc-and-mea-and-the-levels-of-plasma-avp-ot-t-and-e2-in-mandarin-vole-fathers
#11
Qianqian Fang, Jianli Wang
Drug abuse often has negative impacts on parenting behavior. The dopamine (DA), arginine vasopressin (AVP) and oxytocin (OT) systems are involved in paternal behavior and drug-induced behaviors. Mandarin voles (Microtus mandarinus) are socially monogamous rodents with high levels of paternal behavior. The aims of this study were to examine the protein expression levels of the DA 2-type receptor (D2R), AVP receptor 1A(V1aR) and OT receptor (OTR) in the nucleus accumbens (NAcc) and medial amygdala (MeA) as well as the plasma hormone responses after mandarin vole fathers were conditioned with their pups or cocaine...
March 4, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28359742/increased-vasopressin-expression-in-the-bnst-accompanies-paternally-induced-territoriality-in-male-and-female-california-mouse-offspring
#12
Christine N Yohn, Amanda B Leithead, Elizabeth A Becker
While developmental consequences of parental investment on species-typical social behaviors has been extensively characterized in same-sex parent-offspring interactions, the impact of opposite-sex relationships is less clear. In the bi-parental California mouse (Peromyscus californicus), paternal retrieval behavior induces territorial aggression and the expression of arginine vasopressin (AVP) in adult male offspring. Although similar patterns of territorially emerge among females, the sexually dimorphic AVP system has not been considered since it is generally thought to regulate male-typical behavior...
April 24, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28352364/2-4-6-trimethyl-n-3-trifluoromethyl-phenyl-benzenesulfonamide-increases-calcium-influx-in-lipopolisaccharide-pre-treated-arteries
#13
Elżbieta Grześk, Katarzyna Szadujkis-Szadurska, Elżbieta Bloch-Bogusławska, Michał Wiciński, Bartosz Malinowski, Sylwia KołTan, Barbara Tejza, Maciej Pujanek, Grzegorz GrześK
It has been demonstrated that 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide (m-3M3FBS) activates phospholipase C (PLC) and stimulates apoptosis in smooth muscle cells, which may increase vascular reactivity. The primary aim of the present study was to evaluate the physiological effects of the direct stimulation of PLC by m-3M3FBS on vascular smooth muscle reactivity in arteries pre-treated with lipopolysaccharides (LPS) as a model of septic shock. Experiments were performed on isolated and perfused tail arteries of Wistar rats...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28351056/comparison-of-umbilical-serum-copeptin-relative-to-erythropoietin-and-s100b-as-asphyxia-biomarkers-at-birth
#14
Milla Summanen, Laura Seikku, Petri Rahkonen, Vedran Stefanovic, Kari Teramo, Sture Andersson, Kai Kaila, Leena Rahkonen
BACKGROUND: Birth asphyxia, estimated to account for a million neonatal deaths annually, can cause a wide variety of neurodevelopmental impairments. There is a need to develop new, swift methods to identify those neonates who would benefit from neuroprotective treatments such as hypothermia. OBJECTIVES: To examine the utility of cord serum copeptin, a stable byproduct of arginine vasopressin release, as a biomarker of birth asphyxia based on a comparison with 2 biomarkers of hypoxia and brain trauma: erythropoietin and S100B...
March 29, 2017: Neonatology
https://www.readbyqxmd.com/read/28350495/out-group-threat-responses-in-group-bias-and-nonapeptide-involvement-are-conserved-across-vertebrates-a-comment-on-bruintjes-et-al-out-group-threat-promotes-within-group-affiliation-in-a-cooperative-fish
#15
Martin Kavaliers, Elena Choleris
The challenges and threats posed by out-groups have major effects on human social behavior and how individuals interact with one another. We briefly review evidence here that out-group threat similarly affects nonhuman animal behavior. Actual and potential threats posed by out-group individuals (unfamiliar and genetically nonrelated individuals of the same species) affect social behavior promoting "out-group" avoidance and "in-group" bias and enhancing in-group (familiar and/or genetically related individuals) affiliation and interactions...
April 2017: American Naturalist
https://www.readbyqxmd.com/read/28325880/balancing-selection-maintains-polymorphisms-at-neurogenetic-loci-in-field-experiments
#16
Eija Lonn, Esa Koskela, Tapio Mappes, Mikael Mokkonen, Angela M Sims, Phillip C Watts
Most variation in behavior has a genetic basis, but the processes determining the level of diversity at behavioral loci are largely unknown for natural populations. Expression of arginine vasopressin receptor 1a (Avpr1a) and oxytocin receptor (Oxtr) in specific regions of the brain regulates diverse social and reproductive behaviors in mammals, including humans. That these genes have important fitness consequences and that natural populations contain extensive diversity at these loci implies the action of balancing selection...
April 4, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28316971/exercise-associated-hyponatremia-2017-update
#17
REVIEW
Tamara Hew-Butler, Valentina Loi, Antonello Pani, Mitchell H Rosner
Exercise-associated hyponatremia (EAH) was initially described in the 1980s in endurance athletes, and work done since then has conclusively identified that overdrinking beyond thirst and non-osmotic arginine vasopressin release are the most common etiologic factors. In recent years, EAH has been described in a broader variety of athletic events and also has been linked to the development of rhabdomyolysis. The potential role of volume and sodium depletion in a subset of athletes has also been described. This review focuses on the most recent literature in the field of EAH and summarizes key new findings in the epidemiology, pathophysiology, treatment, and prevention of this condition...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28294453/a-translational-approach-for-nmda-receptor-profiling-as-a-vulnerability-biomarker-for-depression-and-schizophrenia
#18
Handan Gunduz-Bruce, Joshua Kenney, Suravi Changlani, Aldo Peixoto, Ralitza Gueorguieva, Cheryl Leone, Nina Stachenfeld
What is the central question of this study? Can the change in plasma arginine vasopressin concentration (P[AVP] ) in response to osmotic stimulation (POsm ) serve as a biomarker for NMDA receptor signalling in schizophrenia and depression and thereby distinguish between these mental illnesses? What is the main finding and its importance? In response to hyperosmotic challenge, depressed subjects showed increased P[AVP] response compared with healthy control and schizophrenic subjects. However, schizophrenic subjects were not different from healthy control subjects in this small sample...
March 13, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28293470/hypothalamic-pituitary-adrenal-axis-and-depression-symptom-effects-of-an-arginine-vasopressin-type-1b-receptor-antagonist-in-a-one-week-randomized-phase-1b-trial
#19
David A Katz, Charles Locke, Nicholas Greco, Wei Liu, Katherine A Tracy
BACKGROUND: Arginine vasopressin 1B receptor (V1B) antagonists may have utility for the treatment of major depressive disorder (MDD). METHODS: The V1B antagonist ABT-436 (N = 31) or matching placebo (N = 20) was administered to MDD subjects for 7 days. The main study objectives were to assess the safety and hypothalamic-pituitary-adrenal axis (HPA) effects of ABT-436 in MDD subjects. MDD symptoms were assessed using the 17-item Hamilton Depression Rating Scale (HAM-D-17) and the subject-rated Mood and Anxiety Symptom Questionnaire (MASQ)...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28288796/opposite-effects-of-nonapeptide-antagonists-on-paternal-behavior-in-the-teleost-fish-amphiprion-ocellaris
#20
Ross DeAngelis, Joseph Gogola, Logan Dodd, Justin S Rhodes
The nonapeptides isotocin (IT) and arginine vasotocin (AVT), along with their mammalian homologs oxytocin and arginine vasopressin, are well known regulators of social behaviors across vertebrate taxa. However, little is known about their involvement in paternal care. Here, we measured the effect of an IT and an AVT V1a receptor antagonist on paternal behaviors in the primarily paternal teleost Amphiprion ocellaris. We also measured the effect of the IT receptor antagonist on aggression in dyadic contests between two non-reproductive fish to assess specificity of the effect on paternal behaviors...
March 17, 2017: Hormones and Behavior
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