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Arginine vasopressin

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https://www.readbyqxmd.com/read/27932956/hypothalamic-vasopressinergic-projections-innervate-central-amygdala-gabaergic-neurons-implications-for-anxiety-and-stress-coping
#1
Vito S Hernández, Oscar R Hernández, Miguel Perez de la Mora, María J Gómora, Kjell Fuxe, Lee E Eiden, Limei Zhang
The arginine-vasopressin (AVP)-containing hypothalamic magnocellular neurosecretory neurons (VPMNNs) are known for their role in hydro-electrolytic balance control via their projections to the neurohypophysis. Recently, projections from these same neurons to hippocampus, habenula and other brain regions in which vasopressin infusion modulates contingent social and emotionally-affected behaviors, have been reported. Here, we present evidence that VPMNN collaterals also project to the amygdaloid complex, and establish synaptic connections with neurons in central amygdala (CeA)...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27931650/effect-of-non-adrenergic-vasopressors-on-macro-and-microvascular-coupling-in-distributive-shock
#2
REVIEW
M Hessler, T G Kampmeier, S Rehberg
The present review initially describes the rationale for the use of non-adrenergic vasopressors in the treatment of distributive shock and then provides an overview of the individual vasopressin-receptor agonists, namely arginine vasopressin, terlipressin, and selepressin. Following a brief summary of their current use in clinical practice, the present review focuses on the influence of vasopressin-receptor agonists on macro- and microvascular coupling, also referred to as hemodynamic coherence. On the basis of the current evidence from experimental and clinical studies, vasopressin-receptor agonists do not negatively influence macro- and microvascular coupling as compared to the standard therapy with norepinephrine, when used in established treatment regimes...
December 2016: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/27930444/a-mysterious-role-of-arginine-vasopressin-levels-in-m%C3%A3-ni%C3%A3-re-s-disease-meta-analysis-of-clinical-studies
#3
Jing Wu, Jie Zhou, Lu Dong, Wenjing Fan, Jinyu Zhang, Caiqin Wu
OBJECTIVE: There are contradicting claims that patients with Ménière's disease (MD) have elevated levels of arginine vasopressin (AVP). The results of published studies regarding the difference of AVP level between MD patients and non-MD control subjects are inconsistent. We propose that the discrepancy of AVP levels during different MD phases may be a potential reason. Thus, we conducted a meta-analysis to analyze the precise estimate of this hypothesis. DATA SOURCES: PubMed, Medline, and Cochrane databases from the earliest publication, up until September 2016; references from meta-analyses and related review articles...
December 7, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27928437/increased-copeptin-levels-in-metabolic-syndrome-from-a-romanian-population
#4
Vintilă M, Gheorghiu Ml, Caragheorgheopol A, Baculescu N, Lichiardopol C, Badiu C, Coculescu M, Grigorescu F, Poiană C
Rationale: Arginine vasopressin (AVP) is secreted under conditions of water deprivation. Since AVP has a low half-life in the plasma, the C-terminal fragment of AVP-precursor (copeptin) was used to estimate the AVP levels. High copeptin levels increase the risk for the development of diabetes mellitus. Aim: This study was aimed to measure copeptin levels in the metabolic syndrome (MetS) in Romanians using a competitive enzyme immunoassay. Methods and results: Patients prone to present MetS (n = 63) were compared to controls (n = 42)...
October 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27923411/reliability-of-basal-plasma-vasopressin-concentrations-in-healthy-male-adults
#5
Daniel S Quintana, Lars T Westlye, Knut T Smerud, Ramy A Mahmoud, Per G Djupesland, Ole A Andreassen
OBJECTIVE: The neuropeptides oxytocin (OT) and arginine vasopressin (AVP) play important and interrelated roles in modulating mammalian social behaviour. While the OT system has received considerable research attention for its potential to treat psychiatric symptoms, comparatively little is known about the role of the AVP system in human social behaviour. To better understand the intraindividual stability of basal AVP, the present study assessed the reproducibility of basal plasma AVP concentrations...
December 7, 2016: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27917269/ecstasy-mdma-and-its-effects-on-kidneys-and-their-treatment-a-review
#6
REVIEW
Feyza Bora, Fatih Yılmaz, Taner Bora
Ecstasy (MDMA; 3,4-methylenedioxymethylamphetamine) is an illicit drug that has been increasingly abused by young people. Its effects include euphoria, enhanced sociability and heightened mental awareness. These come about via the increase of serotonin in both the central nervous system and the sympathetic nervous system. Despite the drug's prevalent abuse, serious or adverse effects are rare. Due to personal pharmacokinetics, effects from the same dosage vary according to the individual. Fatal instances may include acute hyponatremia, hyperthermia (>42 °C), disseminated intravascular coagulation (DIC) resulting from hyperthermia affecting the kidneys, and non-traumatic rhabdomyolysis...
November 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27913547/new-treatment-approaches-to-von-willebrand-disease
#7
Michelle Lavin, James S O'Donnell
von Willebrand disease (VWD) is the commonest inherited bleeding disorder and results from either a quantitative or qualitative deficiency in the plasma glycoprotein von Willebrand factor (VWF). Recent large cohort studies have significantly enhanced our understanding of the molecular mechanisms involved in the pathogenesis of VWD. In contrast, however, there have been relatively few advances in the therapeutic options available for the treatment of bleeding in patients with VWD. Established treatment options include tranexamic acid, 1-deamino-8-d-arginine vasopressin (DDAVP), and plasma-derived VWF concentrates...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27881080/genotypic-differences-in-intruder-evoked-immediate-early-gene-activation-in-male-but-not-female-vasopressin-1b-receptor-knockout-mice
#8
Shannah K Witchey, Erica L Stevenson, Heather K Caldwell
BACKGROUND: The neuropeptide arginine vasopressin (Avp) modulates social behaviors via its two centrally expressed receptors, the Avp 1a receptor and the Avp 1b receptor (Avpr1b). Recent work suggests that, at least in mice, Avp signaling through Avpr1b within the CA2 region of the hippocampus is critical for normal aggressive behaviors and social recognition memory. However, this brain area is just one part of a larger neural circuit that is likely to be impacted in Avpr1b knockout (-/-) mice...
November 24, 2016: BMC Neuroscience
https://www.readbyqxmd.com/read/27874273/association-testing-of-vasopressin-receptor-1a-microsatellite-polymorphisms-in-non-clinical-autism-spectrum-phenotypes
#9
Tanya L Procyshyn, Peter L Hurd, Bernard J Crespi
Variation in the arginine vasopressin receptor 1a (AVPR1a) gene is associated with autism risk in clinical populations and with variation in social behavior in non-clinical populations. However, whether a relationship exists between AVPR1a polymorphisms and non-clinical manifestations of autism spectrum phenotypes has not been established. In this study, 873 Caucasian university students were administered the Autism-spectrum Quotient (AQ) questionnaire and genotyped for the RS1 and RS3 microsatellites. A significant association was found between RS3 microsatellite variation and AQ score, with the long/long RS3 genotype associated with higher AQ score...
November 22, 2016: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/27870395/sex-differences-in-associations-of-arginine-vasopressin-and-oxytocin-with-resting-state-functional-brain-connectivity
#10
Leah H Rubin, Li Yao, Sarah K Keedy, James L Reilly, Jeffrey R Bishop, C Sue Carter, Hossein Pournajafi-Nazarloo, Lauren L Drogos, Carol A Tamminga, Godfrey D Pearlson, Matcheri S Keshavan, Brett A Clementz, Scot K Hill, Wei Liao, Gong-Jun Ji, Su Lui, John A Sweeney
Oxytocin (OT) and arginine vasopressin (AVP) exert robust and sexually dimorphic influences on cognition and emotion. How these hormones regulate relevant functional brain systems is not well understood. OT and AVP serum concentrations were assayed in 60 healthy individuals (36 women). Brain functional networks assessed with resting-state functional magnetic resonance imaging (rs-fMRI) were constructed with graph theory-based approaches that characterize brain networks as connected nodes. Sex differences were demonstrated in rs-fMRI...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27862165/grk2-%C3%AE-arrestin-mediates-arginine-vasopressin-induced-cardiac-fibroblast-proliferation
#11
Yunxuan Chen, Feifei Xu, Lingling Zhang, Xiaojun Wang, Yifan Wang, AnthonyYiu-Ho Woo, Weizhong Zhu
Cardiac fibrosis is a pathological feature commonly foundinheartsexposed to hemodynamic orneurohormonal stress. Elevated levels of arginine vasopressin (AVP) are closely associated with the progression ofheart failure and could be an underlyingcauseof cardiac fibrosis. The aim of this study is to characterize the effect of AVP on neonatal rat cardiac fibroblasts (NRCFs) and to illustrate itssignallingmechanism. The proliferative effect of AVP was assessed by methylthiazolyldiphenyl-tetrazoliumassay and 5-bromo-2'-deoxyuridine (BrdU) incorporation assay, and the amounts of cellular signallingproteins α-smooth muscle actin(α-SMA),matrix metalloproteinase (MMP) 2, MMP9, and phosphorylated ERK1/2 were determined by Western blotting...
November 14, 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27857840/tolvaptan-use-during-hyperhydration-in-paediatric-intracranial-lymphoma-with-siadh
#12
Ruben H Willemsen, Violeta Delgado-Carballar, Daniela Elleri, Ajay Thankamony, G A Amos Burke, James C Nicholson, David B Dunger
: An 11-year-old boy developed severe syndrome of inappropriate antidiuretic hormone secretion (SIADH) after diagnosis of an intracranial B-cell lymphoma. His sodium levels dropped to 118-120 mmol/L despite 70% fluid restriction. For chemotherapy, he required hyperhydration, which posed a challenge because of severe hyponatraemia. Tolvaptan is an oral, highly selective arginine vasopressin V2-receptor antagonist, which has been licensed in adults for the management of SIADH and has been used in treating paediatric heart failure...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27845884/central-diabetes-insipidus-clinical-profile-that-suggests-organicity-in-peruvian-children-lima-peru-2001-2013
#13
Miguel Angel De Los Santos, Carlos Manuel Del Águila, Maria Isabel Rojas, Juan Manuel Falen, Oswaldo Nuñez, Eliana Manuela Chávez, Oscar Antonio Espinoza, Paola Marianella Pinto, Martha Rosario Calagua
BACKGROUND: Central diabetes insipidus (CDI) is a heterogeneous disease caused by arginine vasopressin deficiency; its management implies a profound understanding of the pathophysiology and the clinical spectrum. The aim of the study was to describe the clinical characteristics that indicate organicity in children and adolescents with central diabetes insipidus treated at the Department of Endocrinology from The Child Health's Institute during 2001 to 2013. METHODS: Cross-sectional, retrospective study...
December 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27843437/paraventricular-hypothalamic-mechanisms-of-chronic-stress-adaptation
#14
REVIEW
James P Herman, Jeffrey G Tasker
The hypothalamic paraventricular nucleus (PVN) is the primary driver of hypothalamo-pituitary-adrenocortical (HPA) responses. At least part of the role of the PVN is managing the demands of chronic stress exposure. With repeated exposure to stress, hypophysiotrophic corticotropin-releasing hormone (CRH) neurons of the PVN display a remarkable cellular, synaptic, and connectional plasticity that serves to maximize the ability of the HPA axis to maintain response vigor and flexibility. At the cellular level, chronic stress enhances the production of CRH and its co-secretagogue arginine vasopressin and rearranges neurotransmitter receptor expression so as to maximize cellular excitability...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27837170/differential-contributions-of-vasopressin-v1a-and-oxytocin-receptors-in-the-amygdala-to-pain-related-behaviors-in-rats
#15
Bryce Cragg, Guangchen Ji, Volker Neugebauer
Neuroplastic changes in the amygdala account for emotional-affective aspects of pain and involve neuropeptides such as calcitonin gene-related peptide and corticotropin-releasing factor. Another neuropeptide system, central arginine vasopressin, has been implicated in neuropsychiatric disorders, but its role in pain-related emotional expression and neuroplasticity remains to be determined. Here, we tested the hypothesis that arginine vasopressin in the amygdala contributes to pain-related emotional-affective responses, using stereotaxic applications of arginine vasopressin and antagonists for G-protein coupled vasopressin V1A and oxytocin receptors in adult male Sprague-Dawley rats...
2016: Molecular Pain
https://www.readbyqxmd.com/read/27829122/opposite-effects-of-central-oxytocin-and-arginine-vasopressin-on-changes-in-gastric-motor-function-induced-by-chronic-stress
#16
Mehmet Bülbül, Osman Sinen, Burcu Gemici, V Nimet İzgüt-Uysal
Hypothalamic oxytocin (OXT) and arginine vasopressin (AVP) are known to act oppositely on hypothalamic-pituitary-adrenal (HPA) axis, stress response and gastrointestinal (GI) motility. In rodents, exposure to restraint stress (RS) delays gastric emptying (GE), however, repeated exposure to the same stressor (chronic homotypic stress (CHS)), the delayed GE is restored to basal level, while hypothalamic OXT is upregulated. In contrast, when rats are exposed to chronic heterotypic stress (CHeS), these adaptive changes are not observed...
November 6, 2016: Peptides
https://www.readbyqxmd.com/read/27807133/serotonin-and-arginine-vasopressin-mediate-sex-differences-in-the-regulation-of-dominance-and-aggression-by-the-social-brain
#17
Joseph I Terranova, Zhimin Song, Tony E Larkin, Nathan Hardcastle, Alisa Norvelle, Ansa Riaz, H Elliott Albers
There are profound sex differences in the incidence of many psychiatric disorders. Although these disorders are frequently linked to social stress and to deficits in social engagement, little is known about sex differences in the neural mechanisms that underlie these phenomena. Phenotypes characterized by dominance, competitive aggression, and active coping strategies appear to be more resilient to psychiatric disorders such as posttraumatic stress disorder (PTSD) compared with those characterized by subordinate status and the lack of aggressiveness...
November 15, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27804047/chimpanzee-personality-and-the-arginine-vasopressin-receptor-1a-genotype
#18
V A D Wilson, A Weiss, T Humle, N Morimura, T Udono, G Idani, T Matsuzawa, S Hirata, M Inoue-Murayama
Polymorphisms of the arginine vasopressin receptor 1a (AVPR1a) gene have been linked to various measures related to human social behavior, including sibling conflict and agreeableness. In chimpanzees, AVPR1a polymorphisms have been associated with traits important for social interactions, including sociability, joint attention, dominance, conscientiousness, and hierarchical personality dimensions named low alpha/stability, disinhibition, and negative emotionality/low dominance. We examined associations between AVPR1a and six personality domains and hierarchical personality dimensions in 129 chimpanzees (Pan troglodytes) living in Japan or in a sanctuary in Guinea...
November 2, 2016: Behavior Genetics
https://www.readbyqxmd.com/read/27803296/homocysteine-deteriorates-intrahepatic-derangement-and-portal-systemic-collaterals-in-cirrhotic-rats
#19
Hung-Chun Tung, Shao-Jung Hsu, Ming-Hung Tsai, Te-Yueh Lin, I-Fang Hsin, Teh-Ia Huo, Fa-Yauh Lee, Hui-Chun Huang, Hsin-Ling Ho, Han-Chieh Lin, Shou-Dong Lee
In liver cirrhosis, the altered levels of vasoactive substances, especially endothelin-1 (ET-1) and nitric oxide (NO) leads to elevated intrahepatic resistance, increased portal-systemic collaterals, and abnormal intra- and extra-hepatic vascular responsiveness. These derangements aggravate portal hypertension-related complications such as gastroesophageal variceal bleeding. Homocysteine, a substance implicated in cardiovascular diseases, has been found with influences on vasoresponsiveness and angiogenesis...
November 1, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27801846/aqp2-plasma-membrane-diffusion-is-altered-by-the-degree-of-aqp2-s256-phosphorylation
#20
Eva C Arnspang, Frédéric H Login, Jennifer S Koffman, Prabuddha Sengupta, Lene N Nejsum
Fine tuning of urine concentration occurs in the renal collecting duct in response to circulating levels of arginine vasopressin (AVP). AVP stimulates intracellular cAMP production, which mediates exocytosis of sub-apical vesicles containing the water channel aquaporin-2 (AQP2). Protein Kinase A (PKA) phosphorylates AQP2 on serine-256 (S256), which triggers plasma membrane accumulation of AQP2. This mediates insertion of AQP2 into the apical plasma membrane, increasing water permeability of the collecting duct...
October 28, 2016: International Journal of Molecular Sciences
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