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https://www.readbyqxmd.com/read/28802623/an-analytical-model-which-determines-the-apparent-t1-for-modified-look-locker-inversion-recovery-analysis-of-the-longitudinal-relaxation-under-the-influence-of-discontinuous-balanced-classical-molli-and-spoiled-gradient-echo-readouts
#1
Thomas Kampf, Theresa Reiter, Wolfgang Rudolf Bauer
Quantitative nuclear magnetic resonance imaging (MRI) shifts more and more into the focus of clinical research. Especially determination of relaxation times without/and with contrast agents becomes the foundation of tissue characterization, e.g. in cardiac MRI for myocardial fibrosis. Techniques which assess longitudinal relaxation times rely on repetitive application of readout modules, which are interrupted by free relaxation periods, e.g. the Modified Look-Locker Inversion Recovery = MOLLI sequence. These discontinuous sequences reveal an apparent relaxation time, and, by techniques extrapolated from continuous readout sequences, a putative real T1 is determined...
August 9, 2017: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/28801525/exercise-of-obese-mice-induces-cardioprotection-and-oxygen-sparing-in-hearts-exposed-to-high-fat-load
#2
Neoma T Boardman, Anne Dragøy Hafstad, Jim Lund, Line Rossvoll, Ellen Aasum
Exercise training is a potent, therapeutic approach in obesity and diabetes that exerts protective effects against development of diabetic cardiomyopathy and ischemic-injury. Acute increases in circulating fatty acids (FAs) during an ischemic insult can challenge the heart, as high FA-load is considered to have adverse cardiac effects. In the present study, we tested the hypothesis that exercise-induced cardiac effects in diet-induced obese mice are abrogated by an acute high FA-load. Diet-induced obese mice were fed a high-fat diet (HFD) for 20 weeks...
August 11, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28798137/cmr-native-t1-mapping-allows-differentiation-of-reversible-versus-irreversible-myocardial-damage-in-st-segment-elevation-myocardial-infarction-an-oxami-study-oxford-acute-myocardial-infarction
#3
Dan Liu, Alessandra Borlotti, Dafne Viliani, Michael Jerosch-Herold, Mohammad Alkhalil, Giovanni Luigi De Maria, Gregor Fahrni, Sam Dawkins, Rohan Wijesurendra, Jane Francis, Vanessa Ferreira, Stefan Piechnik, Matthew D Robson, Adrian Banning, Robin Choudhury, Stefan Neubauer, Keith Channon, Rajesh Kharbanda, Erica Dall'Armellina
BACKGROUND: CMR T1 mapping is a quantitative imaging technique allowing the assessment of myocardial injury early after ST-segment-elevation myocardial infarction. We sought to investigate the ability of acute native T1 mapping to differentiate reversible and irreversible myocardial injury and its predictive value for left ventricular remodeling. METHODS AND RESULTS: Sixty ST-segment-elevation myocardial infarction patients underwent acute and 6-month 3T CMR, including cine, T2-weighted (T2W) imaging, native shortened modified look-locker inversion recovery T1 mapping, rest first pass perfusion, and late gadolinium enhancement...
August 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28797471/preinfarct-health-status-and-the-use-of-early-invasive-versus-ischemia-guided-management-in-non-st-elevation-acute-coronary-syndrome
#4
Mohammed Qintar, Kim G Smolderen, Paul S Chan, Kensey L Gosch, Philip G Jones, Donna M Buchanan, Saket Girotra, John A Spertus
Early invasive management improves outcomes in non-ST-elevation myocardial infarction (NSTEMI). The association between preinfarct health status and the selecting patients for early invasive management is unknown. The Prospective Registry Evaluating outcomes after Myocardial Infarctions: Events and Recovery and Translational Research Investigating Underlying disparities in acute Myocardial infarction Patients' Health status are consecutive US multicenter registries, in which the associations between preinfarct angina frequency and quality of life (both assessed by the Seattle Angina Questionnaire on admission) and the Global Registry of Acute Coronary Events (GRACE) risk score and referral to early invasive management (coronary angiography within 48 hours) were evaluated using Poisson regression, after adjusting for site, demographics, and clinical and psychosocial variables...
July 14, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28794372/nicorandil-was-an-effective-treatment-option-for-a-patient-with-bland-white-garland-syndrome
#5
Shun Morishita, Hirofumi Maeba, Kazuya Takehana, Ichiro Shiojima
A 75-year-old woman who had previously been diagnosed with Bland-White-Garland syndrome was admitted to our hospital for acute decompensated heart failure (ADHF). Following her recovery from ADHF, pharmacologic stress myocardial scintigraphy revealed myocardial ischemia in the basal anterior area of the left ventricle. Moreover, myocardial scintigraphy showed the improvement of the myocardial ischemia after 6 months of nicorandil administration.
August 10, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28792139/sarpogrelate-based-triple-antiplatelet-therapy-improved-left-ventricular-systolic-function-in-acute-myocardial-infarction-retrospective-study
#6
Jae Hyuk Choi, Jung Rae Cho, Sang Min Park, Kunal Bikram Shaha, Floyd Pierres, Tserendavaa Sumiya, Kwang Jin Chun, Min Kyung Kang, Seonghoon Choi, Namho Lee
PURPOSE: The purpose of this study was to assess the potential benefit of a 5-hydroxytryptamine receptor antagonist, sarpogrelate-based triple antiplatelet therapy (TAPT) in comparison with dual antiplatelet therapy (DAPT) in patients undergoing primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI). MATERIALS AND METHODS: 119 patients of STEMI were retrospectively assessed. All patients received aspirin and clopidogrel per standard of care...
September 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28777197/elabela-improves-cardio-renal-outcome-in-fatal-experimental-septic-shock
#7
David Coquerel, Frédéric Chagnon, Xavier Sainsily, Lauralyne Dumont, Alexandre Murza, Jérôme Côté, Robert Dumaine, Philippe Sarret, Éric Marsault, Dany Salvail, Mannix Auger-Messier, Olivier Lesur
OBJECTIVES: Apelin-13 was recently proposed as an alternative to the recommended β-adrenergic drugs for supporting endotoxin-induced myocardial dysfunction. Since Apelin-13 signals through its receptor (Apelin peptide jejunum) to exert singular inotropic/vasotropic actions and to optimize body fluid balance, this candidate pathway might benefit septic shock management. Whether the newly discovered ELABELA (ELA), a second endogenous ligand of the Apelin peptide jejunum receptor highly expressed in the kidney, further improves cardio-renal impairment remains unknown...
August 2, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28774384/overcoming-the-roadblocks-to-cardiac-cell-therapy-using-tissue-engineering
#8
REVIEW
Mounica Yanamandala, Wuqiang Zhu, Daniel J Garry, Timothy J Kamp, Joshua M Hare, Ho-Wook Jun, Young-Sup Yoon, Nenad Bursac, Sumanth D Prabhu, Gerald W Dorn, Roberto Bolli, Richard N Kitsis, Jianyi Zhang
Transplantations of various stem cells or their progeny have repeatedly improved cardiac performance in animal models of myocardial injury; however, the benefits observed in clinical trials have been generally less consistent. Some of the recognized challenges are poor engraftment of implanted cells and, in the case of human cardiomyocytes, functional immaturity and lack of electrical integration, leading to limited contribution to the heart's contractile activity and increased arrhythmogenic risks. Advances in tissue and genetic engineering techniques are expected to improve the survival and integration of transplanted cells, and to support structural, functional, and bioenergetic recovery of the recipient hearts...
August 8, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28772048/the-effect-of-exercise-training-on-biventricular-myocardial-strain-in-heart-failure-with-preserved-ejection-fraction
#9
Siddhartha S Angadi, Catherine L Jarrett, Moustafa Sherif, Glenn A Gaesser, Farouk Mookadam
AIMS: High-intensity interval training (HIIT) improves peak oxygen uptake and left ventricular diastology in patients with heart failure with preserved ejection fraction (HFpEF). However, its effects on myocardial strain in HFpEF remain unknown. We explored the effects of HIIT and moderate-intensity aerobic continuous training (MI-ACT) on left and right ventricular strain parameters in patients with HFpEF. Furthermore, we explored their relationship with peak oxygen uptake (VO2peak )...
August 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28770092/association-of-admission-testosterone-level-with-st-segment-resolution-in-male-patients-with-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#10
Ahmad Separham, Samad Ghaffari, Bahram Sohrabi, Naser Aslanabadi, Mozhgan Hadavi Bavil, Hasanali Lotfollahi
BACKGROUND: Low level of testosterone may be associated with cardiovascular diseases in men, as some evidence suggests a protective role for testosterone in cardiovascular system. Little is known about the possible role of serum testosterone in response to reperfusion therapy in ST-elevation myocardial infarction (STEMI) and its relationship with ST-segment recovery. The present study was conducted to evaluate the association of serum testosterone levels with ST-segment resolution following primary percutaneous coronary intervention (PPCI) in male patients with acute STEMI...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28766162/intramyocardial-dissecting-hematoma-in-anterior-wall-st-elevation-myocardial-infarction-impact-on-left-ventricular-remodeling-and-prognosis
#11
Letizia Spinelli, Eugenio Stabile, Giuseppe Giugliano, Carmine Morisco, Caterina Anna Giudice, Massimo Imbriaco, Mario Santoro, Giovanni Esposito, Bruno Trimarco
Intramyocardial dissecting hematoma is an uncommon complication of myocardial infarction potentially leading to cardiac rupture. The aim of the present study was to investigate coronary reperfusion results, left ventricular (LV) function recovery and remodeling and clinical outcomes in patients with anterior STEMI complicated by intramyocardial hematoma. We prospectively studied 87 patients (mean age 59 ± 10 years; 88% male) with anterior STEMI (42 with intramyocardial hematoma) in order to evaluate coronary reperfusion results, LV remodeling (≥15% increase in end-systolic volume) and clinical outcomes (cardiac death, non-fatal reinfarction, and hospitalization for congestive heart failure) at 24 months...
August 1, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28765953/atorvastatin-protects-cardiomyocytes-against-ogd-r%C3%A2-induced-apoptosis-by-inhibiting-mir%C3%A2-199a%C3%A2-5p
#12
Yong Li, Ting Jiang, Xingli Fu, Hao Xu, Jianguo Ji
The present study aimed to evaluate the protective effects of atorvastatin against myocardial ischemia/reperfusion (I/R) injury in cardiomyocytes and its underlying mechanisms. The direct cytotoxic effects of oxygen‑glucose deprivation/reperfusion (OGD/R) on cardiomyocytes with and without atorvastatin pretreatment were evaluated. The effects of atorvastatin on the expression of glycogen synthase kinase‑3β (GSK‑3β) and microRNA (miR)‑199a‑5p were determined using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and western blot analyses...
July 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28764773/quantification-of-both-the-area-at-risk-and-acute-myocardial-infarct-size-in-st-segment-elevation-myocardial-infarction-using-t1-mapping
#13
Heerajnarain Bulluck, Matthew Hammond-Haley, Marianna Fontana, Daniel S Knight, Alex Sirker, Anna S Herrey, Charlotte Manisty, Peter Kellman, James C Moon, Derek J Hausenloy
BACKGROUND: A comprehensive cardiovascular magnetic resonance (CMR) in reperfused ST-segment myocardial infarction (STEMI) patients can be challenging to perform and can be time-consuming. We aimed to investigate whether native T1-mapping can accurately delineate the edema-based area-at-risk (AAR) and post-contrast T1-mapping and synthetic late gadolinium (LGE) images can quantify MI size at 1.5 T. Conventional LGE imaging and T2-mapping could then be omitted, thereby shortening the scan duration...
August 1, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28763341/monitoring-platelet-reactivity-during-prasugrel-or-ticagrelor-washout-before-urgent-coronary-artery-bypass-grafting
#14
Katia Orvin, Yaron D Barac, Ran Kornowski, Leor Perl, Yishay Wasserstrum, Victor Rubchevsky, Ram Sharony, Eitan Snir, Dan Aravot, Eli I Lev
OBJECTIVES: Patients with acute myocardial infarction pretreated with prasugrel or ticagrelor may require urgent coronary artery bypass grafting (CABG). However, prasugrel and ticagrelor withdrawal period is recommended for 5-7 days before planned CABG to enable full platelet recovery. We hypothesized that monitoring sequential platelet reactivity (PR) could identify patients with early platelet recovery who may benefit from earlier surgery before the guideline-recommended 5-7 day delay...
September 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28754835/in-vivo-functional-selection-identifies-cardiotrophin-1-as-a-cardiac-engraftment-factor-for-mesenchymal-stromal-cells
#15
Francesca Bortolotti, Giulia Ruozi, Antonella Falcione, Sara Doimo, Matteo Dal Ferro, Pierluigi Lesizza, Lorena Zentilin, Lawrence Banks, Serena Zacchigna, Mauro Giacca
Background -Transplantation of cells into the infarcted heart has significant potential to improve myocardial recovery; however, low efficacy of cell engraftment still limits therapeutic benefit. Here we describe a method for the unbiased, in vivo selection of cytokines that improve mesenchymal stromal cell (MSC) engraftment into the heart in both normal conditions and after myocardial infarction. Methods -An arrayed library of 80 secreted factors, including most of the currently known interleukins and chemokines, were individually cloned into adeno-associated viral (AAV) vectors...
July 28, 2017: Circulation
https://www.readbyqxmd.com/read/28748611/apelin-induced-cardioprotection-against-ischemia-reperfusion-injury-roles-of-epidermal-growth-factor-and-src
#16
Anna Folino, Lisa Accomasso, Claudia Giachino, Pier Giorgio Montarolo, Gianni Losano, Pasquale Pagliaro, Raffaella Rastaldo
AIM: Apelin, the ligand of the G-protein-coupled-receptor (GPCR) APJ, exerts a postconditioning-like protection against ischemia-reperfusion injury through activation of PI3K-Akt-NO signalling. The pathway connecting APJ to PI3K is still unknown. Since other GPCR ligands act through transactivation of epidermal growth factor receptor (EGFR) via a matrix-metalloproteinase (MMP) or Src kinase, we investigated whether EGFR transactivation is involved in the following three features of apelin-induced cardioprotection: limitation of infarct size, suppression of contracture, and improvement of post-ischemic contractile recovery...
July 27, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28744986/complete-recovery-of-fulminant-peripartum-cardiomyopathy-on-mechanical-circulatory-support-combined-with-high-dose-bromocriptine-therapy
#17
Patrick Horn, Diyar Saeed, Payam Akhyari, Denise Hilfiker-Kleiner, Malte Kelm, Ralf Westenfeld
Peripartum cardiomyopathy (PPCM) is an idiopathic cardiomyopathy presenting with heart failure due to left ventricular systolic dysfunction towards the end of pregnancy or in the months following delivery, where no other cause of heart failure is found. We report a case of a woman with PPCM who developed a critical cardiogenic shock with repeated cardiopulmonary resuscitation. We show for the first time that mechanical circulatory support combined with high-dose bromocriptine therapy to suppress systemic prolactin levels may serve as an effective therapeutic option in patients with fulminant PPCM and cardiogenic shock...
July 25, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28740146/in-vivo-imaging-to-monitor-differentiation-and-therapeutic-effects-of-transplanted-mesenchymal-stem-cells-in-myocardial-infarction
#18
Zhijun Pei, Jing Zeng, Yafeng Song, Yan Gao, Ruimin Wu, Yijia Chen, Fuyan Li, Wei Li, Hong Zhou, Yi Yang
Here, we used a noninvasive multimodality imaging approach to monitor differentiation of transplanted bone marrow mesenchymal stem cells (BMSCs) and recovery of cardiac function in an in vivo model of myocardial infarction (MI). We established a rat MI model by coronary artery ligation. Ninety rats were randomly assigned into four groups: sham-operated, MI model, and α-MHC-HSV1-tk-transfected or un-transfected BMSCs-treated MI model. We used (18)F-Fluro-deoxyglucose ((18)F-FDG) positron emission tomography (PET) to monitor recovery of cardiac function, and (18)F-FHBG PET/CT imaging to monitor transplanted BMSCs differentiation 24 h after (18)F-FDG imaging...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28739623/importance-of-temporal-changes-in-myocardial-strain-in-takotsubo-cardiomyopathy
#19
Anjan Tibrewala, Benjamin Howard Freed, Nausheen Akhter
Strain imaging is a sensitive marker of myocardial dysfunction and may be underused in Takotsubo cardiomyopathy (TC). We present a case of biventricular TC in which early improvement in left ventricular longitudinal strain predated subsequent improvement in ejection fraction. Early temporal patterns of strain of the left and right ventricles have not previously been described in TC. Our case illustrates how strain can be a sensitive marker for myocardial dysfunction and recovery in TC. Increased use of strain in TC may have further implications on prognosis and management...
July 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28736756/advancing-the-science-of-myocardial-recovery-with-mechanical-circulatory-support-a-working-group-of-the-national-heart-lung-and-blood-institute
#20
Stavros G Drakos, Francis D Pagani, Martha S Lundberg, J Timothy Baldwin
The medical burden of heart failure (HF) has spurred interest in clinicians and scientists to develop therapies to restore the function of a failing heart. To advance this agenda, the National Heart Lung Blood Institute (NHLBI) convened a Working Group of experts on June 2-3, 2016 in Bethesda Maryland to develop recommendations for the NHLBI aimed at advancing the science of cardiac recovery in the setting of mechanical circulatory support (MCS). MSC devices effectively reduce volume and pressure overload that drives the cycle of progressive myocardial dysfunction, thereby triggering structural and functional reverse remodeling...
June 2017: JACC. Basic to Translational Science
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