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Bérengère Dadone, Denys Fontaine, Lydiane Mondot, Gaël Cristofari, Anne Jouvet, Catherine Godfraind, Pascale Varlet, Dominique Ranchère-Vince, Jean-Michel Coindre, Lauris Gastaud, Christian Baudoin, Annie-Claude Peyron, Antoine Thyss, Michael Coutts, Jean-François Michiels, Florence Pedeutour, Fanny Burel-Vandenbos
AIMS: Bi-allelic inactivation of SMARCB1 (also known as INI1) and loss of immunohistochemical expression of SMARCB1 defines the group of SMARCB1-deficient tumors. Initially highlighted in malignant rhabdoid tumors, this inactivation has subsequently been observed in several intra and extracranial tumors. To date, primary meningeal SMARCB1-deficient tumors have not been described. We report two cases of meningeal SMARCB1-deficient tumors occurring in adults. METHODS: We performed immunohistochemical analyses, comparative genomic hybridization, fluorescence in situ hybridization and targeted next generation sequencing...
October 12, 2016: Neuropathology and Applied Neurobiology
José A Jiménez-Heffernan, Andrés Urquía-Renke, Carmen Bárcena, Javier Fraga
No abstract text is available yet for this article.
October 2016: Diagnostic Cytopathology
Y Cui, J Du, J M Wang, L Xu, G L Li
No abstract text is available yet for this article.
August 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Yosef Laviv, Victoria Ohla, Ekkehard M Kasper
Meningiomas are some of the most frequently encountered adult intracranial tumors. Dramatic flare ups in size may occasionally be observed during pregnancy, leading to complicated clinical scenarios, with profound effects and substantial risks for both the mother's and the fetus's well-being. Despite the fact that such changes have largely been attributed to progesterone-based mechanisms, recent studies have put this theory into question or defied it. In order to assess these particular tumors carefully and to try and clarify the pathophysiology of such pregnancy-related meningioma growth, an in-depth review of the pertinent literature was undertaken...
June 16, 2016: Neurosurgical Review
Rajalakshmi Poyuran, Anita Mahadevan, B K Chandrasekhar Sagar, Jitender Saini, Dwarakanath Srinivas
Chordoid glioma (CG) is a World Health Organization classified grade II tumor located exclusively in the region of anterior third ventricle. Association of CG with other lesions is extremely rare. We report a case of CG in a 45-year-old male coexisting with an epidermoid cyst in the third ventricle. Ultrastructural examination of the CG revealed microvilli, junctional complexes, and intermediate filaments within the cytoplasm suggesting origin from specialized ependyma. The association of the 2 lesions appears coincidental as convincing evidence for a common histogenesis was not found...
October 2016: International Journal of Surgical Pathology
Lain Hermes Gonzalez-Quarante, Fernando Ruiz-Juretschke, Begoña Iza-Vallejo, Esteban Scola-Pliego, Daniel Poletti, Emma Sola Vendrell
BACKGROUND: Meningiomas without dural attachment (MWODA) located in the posterior fossa are an unfrequent entity. They are usually located in the fourth ventricle, and their occurrence outside of this anatomic structure is an even more uncommon finding. Chordoid meningiomas are a rare subtype of meningioma, and they have been reported to account for 0.5%-1% of all meningiomas. CASE DESCRIPTION: We report the unusual case of a 36-year-old female patient, with unremarkable past medical history, who presented at our institution complaining of acute binocular diplopia...
July 2016: World Neurosurgery
Feng Qixing, Gao Peiyi, Wang Kai, Chen Xuzhu, Min Xiangde, Dai Jianping
No abstract text is available yet for this article.
May 2016: Clinical Imaging
Yang Yang, Da Li, Xiao-Yu Cao, Shu-Yu Hao, Liang Wang, Zhen Wu, Jun-Ting Zhang
OBJECTIVE: As one subtype of meningiomas, chordoid meningiomas (CMs) are rarely described. In this study, the authors aimed to analyze the incidence, clinical features, treatment, and prognostic factors of CMs. METHODS: Among 9873 cases of meningioma surgically treated between 2003 and 2013 at Beijing Tiantan Hospital, cases of CM were chosen for analysis and were reviewed retrospectively. To ascertain which factors were related with progression-free survival (PFS), statistical analysis was performed...
September 2016: World Neurosurgery
J G Wei, Z Y Yue, X D Teng
No abstract text is available yet for this article.
April 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Joseph Sanfrancesco, Jesse K McKenney, Mariah Z Leivo, Sounak Gupta, Paul Elson, Donna E Hansel
CONTEXT: -Sarcomatoid urothelial carcinoma (UCa) is a rare but aggressive variant of bladder cancer that can show diagnostic challenges even using ancillary techniques. OBJECTIVE: -To examine immunohistochemical markers in the context of sarcomatoid UCa, including those associated with epithelial-to-mesenchymal transition. DESIGN: -Twenty-eight cases of sarcomatoid UCa were rereviewed. Clinical outcomes were obtained through database search...
June 2016: Archives of Pathology & Laboratory Medicine
Riccardo Soffietti, Roberta Rudà, David Reardon
This chapter describes the epidemiology, pathology, molecular characteristics, clinical and neuroimaging features, treatment, outcome, and prognostic factors of the rare glial tumors. This category includes subependymal giant cell astrocytoma, pleomorphic xanthoastrocytoma, astroblastoma, chordoid glioma of the third ventricle, angiocentric glioma, ganglioglioma, desmoplastic infantile astrocytoma and ganglioma, dysembryoplastic neuroepithelial tumor, papillary glioneuronal tumor, and rosette-forming glioneuronal tumor of the fourth ventricle...
2016: Handbook of Clinical Neurology
Junmei Wang, Zhaoxia Liu, Jiang Du, Yun Cui, Jingyi Fang, Li Xu, Guilin Li
Pituicytoma is rare and difficult to diagnose. This study explored the clinicopathological features, immunophenotype and differential diagnosis of pituicytoma. We compared 11 cases of pituicytoma and 26 cases of sellar glioma (16 pilocytic astrocytomas, four diffuse astrocytomas, three pilomyxoid astrocytomas, and three third ventricle chordoid gliomas). The 11 pituicytoma cases involved six men and five women (age: 33-65 years). Three of the 11 patients experienced recurrence due to a residual tumor, and one patient underwent three surgeries during a 6-month period...
February 26, 2016: Neuropathology: Official Journal of the Japanese Society of Neuropathology
Matilde Calanchini, Simon Cudlip, Monika Hofer, James Byrne, Andrea Fabbri, Ashley Grossman
INTRODUCTION: Chordoid glioma of the third ventricle is a rare and recently described tumor characterized by a unique histomorphology and exclusive association with the suprasellar/third ventricular compartment. Its clinical, radiological and histological features may vary. Despite the fact that chordoid glioma is a low-grade tumor, its prognosis has been relatively poor because of its insidious presentation and the difficulty in obtaining complete surgical resection. MATERIALS AND METHODS: Here, we report on a new case of chordoid glioma occurring in a 48-year-old woman, presented with hyponatremia, and on the initial work-up with a diagnosis of hyponatremia due at least in part to SIADH...
August 2016: Pituitary
So Yeon Ki, Seul Kee Kim, Tae Wook Heo, Byung Hyun Baek, Hyung Seok Kim, Woong Yoon
Chordoid glioma is a rare low grade tumor typically located in the third ventricle. Although a chordoid glioma can arise from ventricle with tumor cells having features of ependymal differentiation, intraventricular dissemination has not been reported. Here we report a case of a patient with third ventricular chordoid glioma and intraventricular dissemination in the lateral and fourth ventricles. We described the perfusion MR imaging features of our case different from a previous report.
January 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
Liang Wu, Tao Yang, Jingyi Fang, Junting Zhang, Yulun Xu
As an uncommon subtype of meningioma, chordoid meningioma (CM) of the spinal canal is extremely rare. There have been only two reported cases of intraspinal CM in the literature, and this lesion has not been previously reported in the pediatric age group. To the best of our knowledge, the present study reports the first case of spinal chordoid meningioma in a pediatric patient. A 12-year-old female presented with a 3-month history of progressive numbness and weakness in the right-side limbs, and intermittent pain in the neck and right shoulder...
December 2015: Oncology Letters
Mónica B Mezmezian, Mónica B Carassai, Valeria Dopazo, María L Deforel, María Á Puzzo
INTRODUCTION: Immunostaining of progesterone receptors (PRs) has been described as a prognostic factor related to recurrences in meningiomas. However, its expression in other primary intracranial tumors has been poorly studied. In this paper, we compare the pattern of expression of the receptor in meningiomas with that of nonmeningothelial intracranial tumors to evaluate its value in the diagnosis of the former. MATERIALS AND METHODS: A total of 42 nonmeningothelial intracranial tumors (21 glioblastomas, 4 anaplastic oligodendrogliomas, 4 oligodendrogliomas, 1 pilomyxoid astrocytoma, 3 ependymomas, 8 schwannomas, 1 chordoid chordoma) and 32 meningiomas (1 rhabdoid, 1 papillary, 5 atypical, 7 with histologic features of more aggressive behavior, 1 microcyst, 8 meningothelial, 7 transitional, 2 fibroblastic) were studied for PR by immunohistochemistry...
January 13, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
Marília Henrique Destefani, Alessandro Spanó Mello, Ricardo Santos de Oliveira, Gustavo Novelino Simão
No abstract text is available yet for this article.
September 2015: Radiologia Brasileira
Winward Choy, Leonel Ampie, Jonathan B Lamano, Kartik Kesavabhotla, Qinwen Mao, Andrew T Parsa, Orin Bloch
No abstract text is available yet for this article.
October 22, 2015: Journal of Neuro-oncology
Fouzia Siraj, Mariya K Ansari, K C Sharma, Avninder Singh
Chordoid meningioma (CM), classified as Grade II/atypical meningioma according to the World Health Organization classification, is a rare subtype, which represents only 0.5% of all meningiomas. Morphologically, it can mimic other chondroid and myxoid tumors within the brain and its vicinity thus posing a diagnostic challenge. Accurate diagnosis, therefore, assumes importance as these tumors have an aggressive clinical course and propensity to recur compared to classical meningiomas. Furthermore, the prognosis and treatment strategies vary when compared to tumors with morphological overlap...
July 2015: Journal of Cancer Research and Therapeutics
Winward Choy, Leonel Ampie, Jonathan B Lamano, Kartik Kesavabhotla, Qinwen Mao, Andrew T Parsa, Orin Bloch
Management of chordoid meningiomas (CMs) is complicated by high rates of recurrence, particularly following subtotal resection. Optimal management is not established given the paucity of published experience. To identify prognostic factors for recurrence following resection, the authors conducted the largest systematic review of CMs to date. A comprehensive search on MEDLINE (OVID and Pubmed), Scopus, Embase, and Web of Science utilizing the search terms "chordoid" AND "meningioma" was performed to identify all reports of pathologically confirmed intracranial CMs...
January 2016: Journal of Neuro-oncology
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