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https://www.readbyqxmd.com/read/29588902/gross-total-resection-of-chordoid-glioma-of-the-third-ventricle-via-anterior-interhemispheric-transcallosal-transforaminal-approach-at-two-stages
#1
Ihsan Dogan, Melih Ucer, Mustafa Kemal Başkaya
Suprasellar tumors in particular tumors located in the retrochiasmatic area and anterior third ventricle are challenging cases in terms of optimal surgical exposure. Several approaches have been described including transsylvian, translamina terminalis, endoscopic endonasal, and anterior interhemispheric. Each approach has advantages and disadvantages. In this video, we present a case of retrochiasmatic anterior third ventricular tumor that was operated via anterior interhemispheric transcallosal transforaminal approach...
April 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29476136/a-recurrent-kinase-domain-mutation-in-prkca-defines-chordoid-glioma-of-the-third-ventricle
#2
Benjamin Goode, Gourish Mondal, Michael Hyun, Diego Garrido Ruiz, Yu-Hsiu Lin, Jessica Van Ziffle, Nancy M Joseph, Courtney Onodera, Eric Talevich, James P Grenert, Iman H Hewedi, Matija Snuderl, Daniel J Brat, Bette K Kleinschmidt-DeMasters, Fausto J Rodriguez, David N Louis, William H Yong, M Beatriz Lopes, Marc K Rosenblum, Nicholas Butowski, Tarik Tihan, Andrew W Bollen, Joanna J Phillips, Arun P Wiita, Iwei Yeh, Matthew P Jacobson, Boris C Bastian, Arie Perry, David A Solomon
Chordoid glioma is a rare brain tumor thought to arise from specialized glial cells of the lamina terminalis along the anterior wall of the third ventricle. Despite being histologically low-grade, chordoid gliomas are often associated with poor outcome, as their stereotypic location in the third ventricle makes resection challenging and efficacious adjuvant therapies have not been developed. Here we performed genomic profiling on 13 chordoid gliomas and identified a recurrent D463H missense mutation in PRKCA in all tumors, which localizes in the kinase domain of the encoded protein kinase C alpha (PKCα)...
February 23, 2018: Nature Communications
https://www.readbyqxmd.com/read/29380221/chordoid-meningioma-a-clinico-pathological-study-of-an-uncommon-variant-of-meningioma
#3
Nishanth Sadashiva, Rajalakshmi Poyuran, Anita Mahadevan, Dhananjaya I Bhat, Sampath Somanna, Bhagavatula Indira Devi
Chordoid meningioma is a rare variant of meningioma, with a higher incidence in the young and a supposed association with Castleman's syndrome. They have an aggressive clinical course, and are assigned as WHO grade II meningiomas. To the best of our knowledge, 284 chordoid meningiomas have been reported in the literature. This series reporting 33 cases is the third largest series in published literature from a single Institution. We reviewed Clinico-pathological characteristics of 33 patients diagnosed with chordoid meningioma between 2001 and 2015 in our institution...
January 27, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29355032/a-thoracic-extradural-chordoid-meningioma-a-unique-case-report-and-literature-review
#4
Isabel Tulloch, Husam Georges, Rahul Phadke, Carl Hardwidge
We describe the unique case of a patient being diagnosed with a thoracic extradural chordoid meningioma following her presentation with mild lower limb pyramidal weakness and a T8 sensory level. This is the first report of an extradural chordoid meningioma being identified in the thoracic spine. The tumour was successfully resected through a posterior thoracic laminectomy approach. Post-operatively, her neurological deficit resolved and to date she has not experienced a radiological recurrence. In this report, we review the literature and discuss this unusual tumour's characteristics and prognostic significance...
January 22, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29322978/chromosomal-aberrations-in-chordoid-meningioma-an-analysis
#5
Harsha Sugur, Arun H Shastry, Nishant Sadashiva, Dwarakanath Srinivas, Vani Santosh, Sampath Somanna
INTRODUCTION: Chordoid meningiomas (CMs) are a rare subgroup of tumors, accounting for approximately 0.5% of all meningiomas. These tumors correspond to World Health Organization (WHO) Grade II lesions and behave aggressively, with an increased likelihood of recurrence. There are only two studies that have described the genetic alterations in CMs. While a majority of meningiomas are known to have deletion at many chromosomal loci such as 22q, 18p, 14q, and 1p, which are found to be associated with initiation, progression, and malignancy of these tumors, these have not yet been studied in CMs...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29262517/-lateral-ventricular-chordoid-glioma-in-a-pediatric-patient-a-case-report
#6
F Chen, J G Cao, X L Liu, X Y Yang, C C Zhang, D W Chen
No abstract text is available yet for this article.
December 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29236139/-notochordal-tumors-benign-notochordal-tumors-and-chordomas
#7
REVIEW
T F E Barth, A von Witzleben, P Möller, S Scheil-Bertram
Benign notochordal tumors (BNCT) and chordomas are primary bone tumors of the spine with a predominant localization in the sacrum and clival region followed by the vertebral bodies. Besides the most common variant (NOS [not otherwise specified] with hepatoid or renal carcinoma cell-like differentiation) chordomas with chondroid, and polymorphic to anaplastic morphology are described. An unfavorable variant are pediatric chordomas with a loss of INI-1. BNCT and chordomas are characterized by the following immunohistological profile: vimentin+, cytokeratin+/-, epithelial membrane antigen (EMA)+/-, S100 protein+/-, brachyury+...
December 13, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29066234/the-trans-laminar-terminalis-approach-reduces-mortalities-associated-with-chordoid-glioma-resections-a-case-report-and-a-review-of-20-years-of-literature
#8
REVIEW
C W Huo, V Rathi, A Scarlett, J Galanos, Y Y Wang
No abstract text is available yet for this article.
January 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28885077/innate-immunity-may-play-a-role-in-growth-and-relapse-of-chordoid-meningioma
#9
Ivan Presta, Elia Guadagno, Anna Di Vito, Natalia Malara, Chiara Mignogna, Domenico Maisano, Annalidia Donato, Gabriella Cardillo, Maria Laura Del Basso De Caro, Giuseppe Donato
Chordoid meningioma (CM) is a rare subtype of meningioma, which represents only 0.5% of all meningiomas. It is classified as Grade II according to the World Health Organization classification because of its tendency to relapse. Pathological and clinical characteristics have been studied in order to forecast the future evolution of the lesions. However, information about infiltration of macrophagic elements and mast cells is very scarce. The authors analyzed the immunohistochemical patterns of three cases and a relapse of CM, in order to verify whether infiltrating macrophages are in a polarized state and what would be the proportion between such elements and mastocytes...
December 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/28708638/chordoid-glioma-a-neoplasm-found-in-the-anterior-part-of-the-third-ventricle
#10
Dianxu Yang, Zhiming Xu, Zhongrun Qian, Lili Wang, Quanmin Nie, Jianwei Ge, Yongming Qiu, Guisong Wang
Chordoid glioma is a rare low-grade tumor that originates almost exclusively in the anterior part of the third ventricle. The diagnosis and treatment of the tumor remain controversial. In this article, the authors present a novel case of chordoid glioma of the third ventricle. The patient was treated with less invasive microsurgery followed by low-dose gamma knife radiosurgery. Magnetic resonance imaging revealed a decrease in tumor size and necrosis in the central region of the tumor, without significant complications at follow-up 14 months later...
July 13, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28681757/management-in-chordoid-glioma-avoiding-the-pitfalls-in-this-rare-and-challenging-entity
#11
Sergio Garcia-Garcia, Iban Aldecoa, Luis Alberto Caral, Enrique Ferrer, Teresa Ribalta, José Juan González-Sánchez
Chordoid glioma (CG) of the third ventricle is an unusual neoplasm of glial nature, which is almost exclusively located in the anterior wall of the third ventricle, in close relation with the hypothalamus. Magnetic resonance images show CG as a suprasellar, hypo- to isointense mass, homogeneously enhancing after the administration of gadolinium. Since its description in 1998 by Brat et al., approximately 85 cases have been reported. Some of its pathological features are under discussion and its histological origin still remains unclear...
July 2017: Neurology India
https://www.readbyqxmd.com/read/28648935/ewsr1-rearrangement-is-present-in-a-subset-of-myoepithelial-tumors-of-salivary-glands-with-variable-morphology-and-does-not-correlate-with-clinical-behavior
#12
Hao Ni, Pei-Yu Zhao, Xiao-Tong Wang, Qiu-Yuan Xia, Xuan Wang, Nan Wu, Shan-Shan Shi, Rui Li, Wan-Rui Yang, Heng-Hui Ma, Xiao-Jun Zhou, Qiu Rao
To investigate that whether myoepithelial tumors of salivary glands (MTs) with EWSR1 rearrangement display distinctive morphological characteristics and whether EWSR1 detection aids to distinguish malignant myoepithelial tumors (MMTs) from benign myoepithelial tumors (BMTs) of salivary glands. We examined 37 cases of MTs, including 24 BMTs, 13 MMTs, by histological, immunohistochemical, and molecular analysis. All of 37 cases were immunoreactive for CKpan, and at least one myoepithelial marker. 26 of 37 cases of MTs were available to be analyzed for EWSR1 rearrangement, with the result that EWSR1 gene break was detected in 4 cases of 15 BMTs, and 4 cases of 11 MMTs...
June 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28466126/uncommon-cranial-meningioma-key-imaging-features-on-conventional-and-advanced-imaging
#13
REVIEW
Nader Zakhari, Carlos Torres, Mauricio Castillo, Thanh B Nguyen
Given the high incidence of intracranial meningiomas encountered in clinical practice, it is not uncommon to find rare subtypes of meningioma, with unusual imaging findings. These commonly represent a diagnostic challenge. In this article, we review the imaging appearance of typical meningioma on conventional and advanced imaging as well as the key imaging features of multiple uncommon subtypes: cystic, microcystic, lipomatous, chordoid, angiomatous, intraosseous, extracranial, atypical/malignant, and tumor-to-tumor metastasis (also known as collision tumors)...
June 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28315998/chordoid-glioma-of-the-third-ventricle-report-of-a-rapidly-progressive-case
#14
Amalie A Erwood, Jose E Velazquez-Vega, Stewart Neill, David A Solomon, Nicholas Butowski, Adam Nowlan, Erin Dunbar, Daniel J Brat
Chordoid gliomas are slowly growing third ventricular tumors that can be challenging to manage clinically. Rapid progression causing death has not been previously reported for this tumor type. We present and discuss a case of chordoid glioma that arose in a 46-year-old female who presented with progressive fatigue, headache, and altered mental status, attributable to severe hydrocephalus caused by a third ventricular mass. She underwent urgent subtotal resection and ventriculo-peritoneal shunt placements. Post-operative MRI noted residual tumor in the anterior resection cavity...
May 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28285812/-a-case-report-of-chordoid-glioma-with-unusual-features-immunohistochemical-and-molecular-findings-and-differential-diagnoses
#15
Arnault Tauziède-Espariat, Gilles Robert, Patricia de Cremoux, Marc Polivka
We report the case of a 63-year-old healthy patient who was admitted for surgery of a suprasellar tumor with extension to the optic chiasm responsible of visual disturbance. Histopathological examination revealed a tumoral proliferation composed of epithelioid cells without atypia arranged in cords in a mucinous matrix surrounded by some lymphocytic inflammatory infiltrates. On immunohistochemistry, the neoplastic cells strongly expressed GFAP and CD34, a weak expression of EMA, an expression of TTF1 without immunoreactivity for brachyury...
April 2017: Annales de Pathologie
https://www.readbyqxmd.com/read/28128724/validation-of-nuclear-stat6-immunostaining-as-a-diagnostic-marker-of-meningeal-solitary-fibrous-tumor-sft-hemangiopericytoma
#16
Anna S Berghoff, Philip Kresl, Michal Bienkowski, Christian Koelsche, Ursula Rajky, Johannes A Hainfellner, Matthias Preusser
INTRODUCTION: NAB2-STAT6 gene fusion is a molecular characteristic of solitary fibrous tumors (SFT) and hemangiopericytoma, underscoring their definition as one diagnostic entity. NAB2-STAT6 fusion is associated with nuclear relocation of STAT6 protein that can be detected by immunohistochemistry. We evaluated the diagnostic value of STAT6 expression in meningeal tumors. METHODS: 77 meningeal tumors (17/77 (22.0%) SFT/hemangiopericytoma, 11/77 meningothelial meningioma, 10/77 atypical meningioma 8/77 chordoid meningioma, 9/77 fibroblastic meningioma, 10/77 transitional meningioma, 3/77 rhabdoid meningioma and 9/77 anaplastic meningioma) were included...
March 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/27910213/dedifferentiated-chordoid-meningioma-with-rhabdomyosarcomatous-differentiation-on-the-middle-cranial-fossa
#17
Hirotaka Fudaba, Tatsuya Abe, Masaki Morishige, Yasutomo Momii, Kenji Kashima, Akira Yamada, Hirofumi Nagatomi, Atsushi Natsume, Junko Hirato, Yoichi Nakazato, Minoru Fujiki
A 46-year-old woman presented with headache and right hemiparesis. MRI demonstrated a mass in the left middle fossa. Total resection was performed. A histological examination of the tumor specimen showed several characteristic morphological features. A chordoid meningioma showing an epithelial-like palisade arrangement was observed. An anaplastic short spindle cell tumor exhibiting a fascicular pattern was considered to be a rhabdomyosarcoma. After conventional radiotherapy, the tumor was well controlled without any neurological deficit for 20 months...
December 2016: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/27856533/neurogenic-fever-in-a-patient-with-a-chordoid-glioma
#18
Rafael García Carretero, Marta Romero Brugera, Oscar Vazquez-Gomez, Noelia Rebollo-Aparicio
Chordoid gliomas are rare tumours. Despite being considered low-grade neoplasms, recent reviews have reported generally poor prognosis due to complications involving severe hypothalamic symptoms. We report a patient aged 30 years with chordoid glioma. What makes this case report interesting is the presence of neurogenic fever, which was already present before the final diagnosis of the brain tumour and also several months after the surgical removal. Since the patient underwent a subtotal resection of the tumour, it remains unclear whether the fever was due to hypothalamic dysfunction or remnants of the tumour...
November 17, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27847580/expanded-endoscopic-transnasal-approach-to-the-chordoid-glioma-of-the-third-ventricle-the-first-case-ever-reported
#19
Mehdi Zeinalizadeh, Seyed Mousa Sadrehosseini, Keyvan Tayebi Meybodi, Ali Heidari Sharifabadi
Chordoid glioma of the third ventricle is a rare and challenging tumor to surgery because of its unique anatomical location and its close juxtaposition to the neurovascular structures and hypothalamus. The authors report a case of chordoid glioma of the third ventricle in a 43-year-old woman, who presented with headache and somnolence. The tumor was approached by endoscopic transnasal technique with a favorable result. Histopathologic examination disclosed a neoplastic tissue composed of eosinophilic epithelioid cells, mucinous, periodic acid Schiff-diastase positive, extracellular matrix, and scattered lymphoplasmacytic infiltrates...
November 2016: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/27732747/meningeal-swi-snf-related-matrix-associated-actin-dependent-regulator-of-chromatin-subfamily-b-member-1-smarcb1-deficient-tumours-an-emerging-group-of-meningeal-tumours
#20
B Dadone, D Fontaine, L Mondot, G Cristofari, A Jouvet, C Godfraind, P Varlet, D Ranchère-Vince, J-M Coindre, L Gastaud, C Baudoin, A-C Peyron, A Thyss, M Coutts, J-F Michiels, F Pedeutour, F Burel-Vandenbos
AIMS: Bi-allelic inactivation of SWI/SNF related, matrix-associated, actin-dependent regulator of chromatin, subfamily B member 1 (SMARCB1; also known as INI1) and loss of immunohistochemical expression of SMARCB1 define the group of SMARCB1-deficient tumours. Initially highlighted in malignant rhabdoid tumours, this inactivation has subsequently been observed in several intra and extracranial tumours. To date, primary meningeal SMARCB1-deficient tumours have not been described. We report two cases of meningeal SMARCB1-deficient tumours occurring in adults...
October 12, 2016: Neuropathology and Applied Neurobiology
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