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Nader Zakhari, Carlos Torres, Mauricio Castillo, Thanh B Nguyen
Given the high incidence of intracranial meningiomas encountered in clinical practice, it is not uncommon to find rare subtypes of meningioma, with unusual imaging findings. These commonly represent a diagnostic challenge. In this article, we review the imaging appearance of typical meningioma on conventional and advanced imaging as well as the key imaging features of multiple uncommon subtypes: cystic, microcystic, lipomatous, chordoid, angiomatous, intraosseous, extracranial, atypical/malignant, and tumor-to-tumor metastasis (also known as collision tumors)...
May 2, 2017: Clinical Neuroradiology
Amalie A Erwood, Jose E Velazquez-Vega, Stewart Neill, David A Solomon, Nicholas Butowski, Adam Nowlan, Erin Dunbar, Daniel J Brat
Chordoid gliomas are slowly growing third ventricular tumors that can be challenging to manage clinically. Rapid progression causing death has not been previously reported for this tumor type. We present and discuss a case of chordoid glioma that arose in a 46-year-old female who presented with progressive fatigue, headache, and altered mental status, attributable to severe hydrocephalus caused by a third ventricular mass. She underwent urgent subtotal resection and ventriculo-peritoneal shunt placements. Post-operative MRI noted residual tumor in the anterior resection cavity...
March 18, 2017: Journal of Neuro-oncology
Arnault Tauziède-Espariat, Gilles Robert, Patricia de Cremoux, Marc Polivka
We report the case of a 63-year-old healthy patient who was admitted for surgery of a suprasellar tumor with extension to the optic chiasm responsible of visual disturbance. Histopathological examination revealed a tumoral proliferation composed of epithelioid cells without atypia arranged in cords in a mucinous matrix surrounded by some lymphocytic inflammatory infiltrates. On immunohistochemistry, the neoplastic cells strongly expressed GFAP and CD34, a weak expression of EMA, an expression of TTF1 without immunoreactivity for brachyury...
April 2017: Annales de Pathologie
Anna S Berghoff, Philip Kresl, Michal Bienkowski, Christian Koelsche, Ursula Rajky, Johannes A Hainfellner, Matthias Preusser
INTRODUCTION: NAB2-STAT6 gene fusion is a molecular characteristic of solitary fibrous tumors (SFT) and hemangiopericytoma, underscoring their definition as one diagnostic entity. NAB2-STAT6 fusion is associated with nuclear relocation of STAT6 protein that can be detected by immunohistochemistry. We evaluated the diagnostic value of STAT6 expression in meningeal tumors. METHODS: 77 meningeal tumors (17/77 (22.0%) SFT/hemangiopericytoma, 11/77 meningothelial meningioma, 10/77 atypical meningioma 8/77 chordoid meningioma, 9/77 fibroblastic meningioma, 10/77 transitional meningioma, 3/77 rhabdoid meningioma and 9/77 anaplastic meningioma) were included...
March 2017: Clinical Neuropathology
Hirotaka Fudaba, Tatsuya Abe, Masaki Morishige, Yasutomo Momii, Kenji Kashima, Akira Yamada, Hirofumi Nagatomi, Atsushi Natsume, Junko Hirato, Yoichi Nakazato, Minoru Fujiki
A 46-year-old woman presented with headache and right hemiparesis. MRI demonstrated a mass in the left middle fossa. Total resection was performed. A histological examination of the tumor specimen showed several characteristic morphological features. A chordoid meningioma showing an epithelial-like palisade arrangement was observed. An anaplastic short spindle cell tumor exhibiting a fascicular pattern was considered to be a rhabdomyosarcoma. After conventional radiotherapy, the tumor was well controlled without any neurological deficit for 20 months...
December 2016: Neuropathology: Official Journal of the Japanese Society of Neuropathology
Rafael García Carretero, Marta Romero Brugera, Oscar Vazquez-Gomez, Noelia Rebollo-Aparicio
Chordoid gliomas are rare tumours. Despite being considered low-grade neoplasms, recent reviews have reported generally poor prognosis due to complications involving severe hypothalamic symptoms. We report a patient aged 30 years with chordoid glioma. What makes this case report interesting is the presence of neurogenic fever, which was already present before the final diagnosis of the brain tumour and also several months after the surgical removal. Since the patient underwent a subtotal resection of the tumour, it remains unclear whether the fever was due to hypothalamic dysfunction or remnants of the tumour...
November 17, 2016: BMJ Case Reports
Mehdi Zeinalizadeh, Seyed Mousa Sadrehosseini, Keyvan Tayebi Meybodi, Ali Heidari Sharifabadi
Chordoid glioma of the third ventricle is a rare and challenging tumor to surgery because of its unique anatomical location and its close juxtaposition to the neurovascular structures and hypothalamus. The authors report a case of chordoid glioma of the third ventricle in a 43-year-old woman, who presented with headache and somnolence. The tumor was approached by endoscopic transnasal technique with a favorable result. Histopathologic examination disclosed a neoplastic tissue composed of eosinophilic epithelioid cells, mucinous, periodic acid Schiff-diastase positive, extracellular matrix, and scattered lymphoplasmacytic infiltrates...
November 2016: Journal of Korean Neurosurgical Society
B Dadone, D Fontaine, L Mondot, G Cristofari, A Jouvet, C Godfraind, P Varlet, D Ranchère-Vince, J-M Coindre, L Gastaud, C Baudoin, A-C Peyron, A Thyss, M Coutts, J-F Michiels, F Pedeutour, F Burel-Vandenbos
AIMS: Bi-allelic inactivation of SWI/SNF related, matrix-associated, actin-dependent regulator of chromatin, subfamily B member 1 (SMARCB1; also known as INI1) and loss of immunohistochemical expression of SMARCB1 define the group of SMARCB1-deficient tumours. Initially highlighted in malignant rhabdoid tumours, this inactivation has subsequently been observed in several intra and extracranial tumours. To date, primary meningeal SMARCB1-deficient tumours have not been described. We report two cases of meningeal SMARCB1-deficient tumours occurring in adults...
October 12, 2016: Neuropathology and Applied Neurobiology
José A Jiménez-Heffernan, Andrés Urquía-Renke, Carmen Bárcena, Javier Fraga
No abstract text is available yet for this article.
October 2016: Diagnostic Cytopathology
Y Cui, J Du, J M Wang, L Xu, G L Li
No abstract text is available yet for this article.
August 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Yosef Laviv, Victoria Ohla, Ekkehard M Kasper
Meningiomas are some of the most frequently encountered adult intracranial tumors. Dramatic flare ups in size may occasionally be observed during pregnancy, leading to complicated clinical scenarios, with profound effects and substantial risks for both the mother's and the fetus's well-being. Despite the fact that such changes have largely been attributed to progesterone-based mechanisms, recent studies have put this theory into question or defied it. In order to assess these particular tumors carefully and to try and clarify the pathophysiology of such pregnancy-related meningioma growth, an in-depth review of the pertinent literature was undertaken...
June 16, 2016: Neurosurgical Review
Rajalakshmi Poyuran, Anita Mahadevan, B K Chandrasekhar Sagar, Jitender Saini, Dwarakanath Srinivas
Chordoid glioma (CG) is a World Health Organization classified grade II tumor located exclusively in the region of anterior third ventricle. Association of CG with other lesions is extremely rare. We report a case of CG in a 45-year-old male coexisting with an epidermoid cyst in the third ventricle. Ultrastructural examination of the CG revealed microvilli, junctional complexes, and intermediate filaments within the cytoplasm suggesting origin from specialized ependyma. The association of the 2 lesions appears coincidental as convincing evidence for a common histogenesis was not found...
October 2016: International Journal of Surgical Pathology
Lain Hermes Gonzalez-Quarante, Fernando Ruiz-Juretschke, Begoña Iza-Vallejo, Esteban Scola-Pliego, Daniel Poletti, Emma Sola Vendrell
BACKGROUND: Meningiomas without dural attachment (MWODA) located in the posterior fossa are an unfrequent entity. They are usually located in the fourth ventricle, and their occurrence outside of this anatomic structure is an even more uncommon finding. Chordoid meningiomas are a rare subtype of meningioma, and they have been reported to account for 0.5%-1% of all meningiomas. CASE DESCRIPTION: We report the unusual case of a 36-year-old female patient, with unremarkable past medical history, who presented at our institution complaining of acute binocular diplopia...
July 2016: World Neurosurgery
Feng Qixing, Gao Peiyi, Wang Kai, Chen Xuzhu, Min Xiangde, Dai Jianping
No abstract text is available yet for this article.
May 2016: Clinical Imaging
Yang Yang, Da Li, Xiao-Yu Cao, Shu-Yu Hao, Liang Wang, Zhen Wu, Jun-Ting Zhang
OBJECTIVE: As one subtype of meningiomas, chordoid meningiomas (CMs) are rarely described. In this study, the authors aimed to analyze the incidence, clinical features, treatment, and prognostic factors of CMs. METHODS: Among 9873 cases of meningioma surgically treated between 2003 and 2013 at Beijing Tiantan Hospital, cases of CM were chosen for analysis and were reviewed retrospectively. To ascertain which factors were related with progression-free survival (PFS), statistical analysis was performed...
September 2016: World Neurosurgery
J G Wei, Z Y Yue, X D Teng
No abstract text is available yet for this article.
April 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Joseph Sanfrancesco, Jesse K McKenney, Mariah Z Leivo, Sounak Gupta, Paul Elson, Donna E Hansel
CONTEXT: -Sarcomatoid urothelial carcinoma (UCa) is a rare but aggressive variant of bladder cancer that can show diagnostic challenges even using ancillary techniques. OBJECTIVE: -To examine immunohistochemical markers in the context of sarcomatoid UCa, including those associated with epithelial-to-mesenchymal transition. DESIGN: -Twenty-eight cases of sarcomatoid UCa were rereviewed. Clinical outcomes were obtained through database search...
June 2016: Archives of Pathology & Laboratory Medicine
Riccardo Soffietti, Roberta Rudà, David Reardon
This chapter describes the epidemiology, pathology, molecular characteristics, clinical and neuroimaging features, treatment, outcome, and prognostic factors of the rare glial tumors. This category includes subependymal giant cell astrocytoma, pleomorphic xanthoastrocytoma, astroblastoma, chordoid glioma of the third ventricle, angiocentric glioma, ganglioglioma, desmoplastic infantile astrocytoma and ganglioma, dysembryoplastic neuroepithelial tumor, papillary glioneuronal tumor, and rosette-forming glioneuronal tumor of the fourth ventricle...
2016: Handbook of Clinical Neurology
Junmei Wang, Zhaoxia Liu, Jiang Du, Yun Cui, Jingyi Fang, Li Xu, Guilin Li
Pituicytoma is rare and difficult to diagnose. This study explored the clinicopathological features, immunophenotype and differential diagnosis of pituicytoma. We compared 11 cases of pituicytoma and 26 cases of sellar glioma (16 pilocytic astrocytomas, four diffuse astrocytomas, three pilomyxoid astrocytomas, and three third ventricle chordoid gliomas). The 11 pituicytoma cases involved six men and five women (age: 33-65 years). Three of the 11 patients experienced recurrence due to a residual tumor, and one patient underwent three surgeries during a 6-month period...
October 2016: Neuropathology: Official Journal of the Japanese Society of Neuropathology
Matilde Calanchini, Simon Cudlip, Monika Hofer, James Byrne, Andrea Fabbri, Ashley Grossman
INTRODUCTION: Chordoid glioma of the third ventricle is a rare and recently described tumor characterized by a unique histomorphology and exclusive association with the suprasellar/third ventricular compartment. Its clinical, radiological and histological features may vary. Despite the fact that chordoid glioma is a low-grade tumor, its prognosis has been relatively poor because of its insidious presentation and the difficulty in obtaining complete surgical resection. MATERIALS AND METHODS: Here, we report on a new case of chordoid glioma occurring in a 48-year-old woman, presented with hyponatremia, and on the initial work-up with a diagnosis of hyponatremia due at least in part to SIADH...
August 2016: Pituitary
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