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C W Huo, V Rathi, A Scarlett, J Galanos, Y Y Wang
No abstract text is available yet for this article.
October 21, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Ivan Presta, Elia Guadagno, Anna Di Vito, Natalia Malara, Chiara Mignogna, Domenico Maisano, Annalidia Donato, Gabriella Cardillo, Maria Laura Del Basso De Caro, Giuseppe Donato
Chordoid meningioma (CM) is a rare subtype of meningioma, which represents only 0.5% of all meningiomas. It is classified as Grade II according to the World Health Organization classification because of its tendency to relapse. Pathological and clinical characteristics have been studied in order to forecast the future evolution of the lesions. However, information about infiltration of macrophagic elements and mast cells is very scarce. The authors analyzed the immunohistochemical patterns of three cases and a relapse of CM, in order to verify whether infiltrating macrophages are in a polarized state and what would be the proportion between such elements and mastocytes...
September 1, 2017: International Journal of Immunopathology and Pharmacology
Dianxu Yang, Zhiming Xu, Zhongrun Qian, Lili Wang, Quanmin Nie, Jianwei Ge, Yongming Qiu, Guisong Wang
Chordoid glioma is a rare low-grade tumor that originates almost exclusively in the anterior part of the third ventricle. The diagnosis and treatment of the tumor remain controversial. In this article, the authors present a novel case of chordoid glioma of the third ventricle. The patient was treated with less invasive microsurgery followed by low-dose gamma knife radiosurgery. Magnetic resonance imaging revealed a decrease in tumor size and necrosis in the central region of the tumor, without significant complications at follow-up 14 months later...
July 13, 2017: Journal of Craniofacial Surgery
Sergio Garcia-Garcia, Iban Aldecoa, Luis Alberto Caral, Enrique Ferrer, Teresa Ribalta, José Juan González-Sánchez
Chordoid glioma (CG) of the third ventricle is an unusual neoplasm of glial nature, which is almost exclusively located in the anterior wall of the third ventricle, in close relation with the hypothalamus. Magnetic resonance images show CG as a suprasellar, hypo- to isointense mass, homogeneously enhancing after the administration of gadolinium. Since its description in 1998 by Brat et al., approximately 85 cases have been reported. Some of its pathological features are under discussion and its histological origin still remains unclear...
July 2017: Neurology India
Hao Ni, Pei-Yu Zhao, Xiao-Tong Wang, Qiu-Yuan Xia, Xuan Wang, Nan Wu, Shan-Shan Shi, Rui Li, Wan-Rui Yang, Heng-Hui Ma, Xiao-Jun Zhou, Qiu Rao
To investigate that whether myoepithelial tumors of salivary glands (MTs) with EWSR1 rearrangement display distinctive morphological characteristics and whether EWSR1 detection aids to distinguish malignant myoepithelial tumors (MMTs) from benign myoepithelial tumors (BMTs) of salivary glands. We examined 37 cases of MTs, including 24 BMTs, 13 MMTs, by histological, immunohistochemical, and molecular analysis. All of 37 cases were immunoreactive for CKpan, and at least one myoepithelial marker. 26 of 37 cases of MTs were available to be analyzed for EWSR1 rearrangement, with the result that EWSR1 gene break was detected in 4 cases of 15 BMTs, and 4 cases of 11 MMTs...
June 2017: Annals of Diagnostic Pathology
Nader Zakhari, Carlos Torres, Mauricio Castillo, Thanh B Nguyen
Given the high incidence of intracranial meningiomas encountered in clinical practice, it is not uncommon to find rare subtypes of meningioma, with unusual imaging findings. These commonly represent a diagnostic challenge. In this article, we review the imaging appearance of typical meningioma on conventional and advanced imaging as well as the key imaging features of multiple uncommon subtypes: cystic, microcystic, lipomatous, chordoid, angiomatous, intraosseous, extracranial, atypical/malignant, and tumor-to-tumor metastasis (also known as collision tumors)...
June 2017: Clinical Neuroradiology
Amalie A Erwood, Jose E Velazquez-Vega, Stewart Neill, David A Solomon, Nicholas Butowski, Adam Nowlan, Erin Dunbar, Daniel J Brat
Chordoid gliomas are slowly growing third ventricular tumors that can be challenging to manage clinically. Rapid progression causing death has not been previously reported for this tumor type. We present and discuss a case of chordoid glioma that arose in a 46-year-old female who presented with progressive fatigue, headache, and altered mental status, attributable to severe hydrocephalus caused by a third ventricular mass. She underwent urgent subtotal resection and ventriculo-peritoneal shunt placements. Post-operative MRI noted residual tumor in the anterior resection cavity...
May 2017: Journal of Neuro-oncology
Arnault Tauziède-Espariat, Gilles Robert, Patricia de Cremoux, Marc Polivka
We report the case of a 63-year-old healthy patient who was admitted for surgery of a suprasellar tumor with extension to the optic chiasm responsible of visual disturbance. Histopathological examination revealed a tumoral proliferation composed of epithelioid cells without atypia arranged in cords in a mucinous matrix surrounded by some lymphocytic inflammatory infiltrates. On immunohistochemistry, the neoplastic cells strongly expressed GFAP and CD34, a weak expression of EMA, an expression of TTF1 without immunoreactivity for brachyury...
April 2017: Annales de Pathologie
Anna S Berghoff, Philip Kresl, Michal Bienkowski, Christian Koelsche, Ursula Rajky, Johannes A Hainfellner, Matthias Preusser
INTRODUCTION: NAB2-STAT6 gene fusion is a molecular characteristic of solitary fibrous tumors (SFT) and hemangiopericytoma, underscoring their definition as one diagnostic entity. NAB2-STAT6 fusion is associated with nuclear relocation of STAT6 protein that can be detected by immunohistochemistry. We evaluated the diagnostic value of STAT6 expression in meningeal tumors. METHODS: 77 meningeal tumors (17/77 (22.0%) SFT/hemangiopericytoma, 11/77 meningothelial meningioma, 10/77 atypical meningioma 8/77 chordoid meningioma, 9/77 fibroblastic meningioma, 10/77 transitional meningioma, 3/77 rhabdoid meningioma and 9/77 anaplastic meningioma) were included...
March 2017: Clinical Neuropathology
Hirotaka Fudaba, Tatsuya Abe, Masaki Morishige, Yasutomo Momii, Kenji Kashima, Akira Yamada, Hirofumi Nagatomi, Atsushi Natsume, Junko Hirato, Yoichi Nakazato, Minoru Fujiki
A 46-year-old woman presented with headache and right hemiparesis. MRI demonstrated a mass in the left middle fossa. Total resection was performed. A histological examination of the tumor specimen showed several characteristic morphological features. A chordoid meningioma showing an epithelial-like palisade arrangement was observed. An anaplastic short spindle cell tumor exhibiting a fascicular pattern was considered to be a rhabdomyosarcoma. After conventional radiotherapy, the tumor was well controlled without any neurological deficit for 20 months...
December 2016: Neuropathology: Official Journal of the Japanese Society of Neuropathology
Rafael García Carretero, Marta Romero Brugera, Oscar Vazquez-Gomez, Noelia Rebollo-Aparicio
Chordoid gliomas are rare tumours. Despite being considered low-grade neoplasms, recent reviews have reported generally poor prognosis due to complications involving severe hypothalamic symptoms. We report a patient aged 30 years with chordoid glioma. What makes this case report interesting is the presence of neurogenic fever, which was already present before the final diagnosis of the brain tumour and also several months after the surgical removal. Since the patient underwent a subtotal resection of the tumour, it remains unclear whether the fever was due to hypothalamic dysfunction or remnants of the tumour...
November 17, 2016: BMJ Case Reports
Mehdi Zeinalizadeh, Seyed Mousa Sadrehosseini, Keyvan Tayebi Meybodi, Ali Heidari Sharifabadi
Chordoid glioma of the third ventricle is a rare and challenging tumor to surgery because of its unique anatomical location and its close juxtaposition to the neurovascular structures and hypothalamus. The authors report a case of chordoid glioma of the third ventricle in a 43-year-old woman, who presented with headache and somnolence. The tumor was approached by endoscopic transnasal technique with a favorable result. Histopathologic examination disclosed a neoplastic tissue composed of eosinophilic epithelioid cells, mucinous, periodic acid Schiff-diastase positive, extracellular matrix, and scattered lymphoplasmacytic infiltrates...
November 2016: Journal of Korean Neurosurgical Society
B Dadone, D Fontaine, L Mondot, G Cristofari, A Jouvet, C Godfraind, P Varlet, D Ranchère-Vince, J-M Coindre, L Gastaud, C Baudoin, A-C Peyron, A Thyss, M Coutts, J-F Michiels, F Pedeutour, F Burel-Vandenbos
AIMS: Bi-allelic inactivation of SWI/SNF related, matrix-associated, actin-dependent regulator of chromatin, subfamily B member 1 (SMARCB1; also known as INI1) and loss of immunohistochemical expression of SMARCB1 define the group of SMARCB1-deficient tumours. Initially highlighted in malignant rhabdoid tumours, this inactivation has subsequently been observed in several intra and extracranial tumours. To date, primary meningeal SMARCB1-deficient tumours have not been described. We report two cases of meningeal SMARCB1-deficient tumours occurring in adults...
October 12, 2016: Neuropathology and Applied Neurobiology
José A Jiménez-Heffernan, Andrés Urquía-Renke, Carmen Bárcena, Javier Fraga
No abstract text is available yet for this article.
October 2016: Diagnostic Cytopathology
Y Cui, J Du, J M Wang, L Xu, G L Li
No abstract text is available yet for this article.
August 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Yosef Laviv, Victoria Ohla, Ekkehard M Kasper
Meningiomas are some of the most frequently encountered adult intracranial tumors. Dramatic flare ups in size may occasionally be observed during pregnancy, leading to complicated clinical scenarios, with profound effects and substantial risks for both the mother's and the fetus's well-being. Despite the fact that such changes have largely been attributed to progesterone-based mechanisms, recent studies have put this theory into question or defied it. In order to assess these particular tumors carefully and to try and clarify the pathophysiology of such pregnancy-related meningioma growth, an in-depth review of the pertinent literature was undertaken...
June 16, 2016: Neurosurgical Review
Rajalakshmi Poyuran, Anita Mahadevan, B K Chandrasekhar Sagar, Jitender Saini, Dwarakanath Srinivas
Chordoid glioma (CG) is a World Health Organization classified grade II tumor located exclusively in the region of anterior third ventricle. Association of CG with other lesions is extremely rare. We report a case of CG in a 45-year-old male coexisting with an epidermoid cyst in the third ventricle. Ultrastructural examination of the CG revealed microvilli, junctional complexes, and intermediate filaments within the cytoplasm suggesting origin from specialized ependyma. The association of the 2 lesions appears coincidental as convincing evidence for a common histogenesis was not found...
October 2016: International Journal of Surgical Pathology
Lain Hermes Gonzalez-Quarante, Fernando Ruiz-Juretschke, Begoña Iza-Vallejo, Esteban Scola-Pliego, Daniel Poletti, Emma Sola Vendrell
BACKGROUND: Meningiomas without dural attachment (MWODA) located in the posterior fossa are an unfrequent entity. They are usually located in the fourth ventricle, and their occurrence outside of this anatomic structure is an even more uncommon finding. Chordoid meningiomas are a rare subtype of meningioma, and they have been reported to account for 0.5%-1% of all meningiomas. CASE DESCRIPTION: We report the unusual case of a 36-year-old female patient, with unremarkable past medical history, who presented at our institution complaining of acute binocular diplopia...
July 2016: World Neurosurgery
Feng Qixing, Gao Peiyi, Wang Kai, Chen Xuzhu, Min Xiangde, Dai Jianping
No abstract text is available yet for this article.
May 2016: Clinical Imaging
Yang Yang, Da Li, Xiao-Yu Cao, Shu-Yu Hao, Liang Wang, Zhen Wu, Jun-Ting Zhang
OBJECTIVE: As one subtype of meningiomas, chordoid meningiomas (CMs) are rarely described. In this study, the authors aimed to analyze the incidence, clinical features, treatment, and prognostic factors of CMs. METHODS: Among 9873 cases of meningioma surgically treated between 2003 and 2013 at Beijing Tiantan Hospital, cases of CM were chosen for analysis and were reviewed retrospectively. To ascertain which factors were related with progression-free survival (PFS), statistical analysis was performed...
September 2016: World Neurosurgery
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