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https://www.readbyqxmd.com/read/28721728/reduced-production-of-higher-alcohols-by-saccharomyces-cerevisiae-in-red-wine-fermentation-by-simultaneously-overexpressing-bat1-and-deleting-bat2
#1
Lijuan Ma, Shiyong Huang, Liping Du, Ping Tang, Dongguang Xiao
In red wine, the contents of higher alcohols and ethyl carbamate (EC) are two significant health concerns. To reduce the production of higher alcohols by wine yeast YZ22 with low production of EC, one BAT2 was replaced by a BAT1 expression cassette first and then another BAT2 was deleted to obtain the mutant SYBB3. Real-Time quantitative PCR showed that the relative expression level of BAT1 in SYBB3 improved 28 times compared with that in YZ22. The yields of isobutanol and 3-methyl-1-butanol produced by mutant SYBB3 reduced by 39...
July 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28718057/immobilized-enzymes-from-geotrichum-spp-improve-wine-quality
#2
Yao Lu, Jing Zhu, Junling Shi, Yanlin Liu, Dongyan Shao, Chunmei Jiang
Higher alcohols are the byproducts of yeasts in alcohol fermentation and are harmful to human health at high concentrations. In this study, immobilized crude enzymes extracted from Geotrichum spp. strains S12 and S13 were separately employed to treat red wine, then GC and GC-MS analyses were used to determine the profiles of volatile compounds in untreated and treated wine samples. Immobilized enzymes from S13 (SA-S13E) were more active in decreasing higher alcohols than enzymes from S12. Conditions for preparing SA-S13E were optimized, and best results were obtained at a sodium alginate concentration of 35 g/L, calcium chloride of 20 g/L, and crude enzyme dosage of 3 mL...
July 17, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28702941/an-application-of-partial-least-squares-for-identifying-dietary-patterns-in-bone-health
#3
Tiffany C Yang, Lorna S Aucott, Garry G Duthie, Helen M Macdonald
In a large cohort of older women, a mechanism-driven statistical technique for assessing dietary patterns that considers a potential nutrient pathway found two dietary patterns associated with lumbar spine and femoral neck bone mineral density. A "healthy" dietary pattern was observed to be beneficial for bone mineral density. INTRODUCTION: Dietary patterns represent a broader, more realistic representation of how foods are consumed, compared to individual food or nutrient analyses. Partial least-squares (PLS) is a data-reduction technique for identifying dietary patterns that maximizes correlation between foods and nutrients hypothesized to be on the path to disease, is more hypothesis-driven than previous methods, and has not been applied to the study of dietary patterns in relation to bone health...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28683524/enhancing-antioxidant-activities-of-wines-by-addition-ofwhite-rose-extract
#4
Hyunbin Seong, Jieun Heo, Kyun Hee Lee, Yoon Bok Lee, Yun Bae Kim, Nam Soo Han
White rose petal extract (WRE) contains large amounts of phenolic compounds and is considered edible. In this study, red and white wines were prepared by the addition of WRE (0.10% or 0.25%, w/v), followed by fermentation at 25°C for 15 days. The fermentation profiles, colors, sensory test results, and antioxidant activities of wines were compared. As reported herein, the fermentation profiles such as the pH, CO2 production rate, and final ethanol concentration were not affected by the addition of WRE, but a slow consumption rate of sugar was observed in 0...
July 7, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28677796/resveratrol-suppresses-thyroid-hormone%C3%A2-induced-osteocalcin-synthesis-in-osteoblasts
#5
Kazuhiko Fujita, Haruhiko Tokuda, Shingo Kainuma, Gen Kuroyanagi, Naohiro Yamamoto, Rie Matsushima-Nishiwaki, Atsushi Harada, Osamu Kozawa, Takanobu Otsuka
Resveratrol, a polyphenolic compound that is present in grape skins, berries and red wine, may be beneficial for human health through its anti‑inflammatory and anti‑oxidant effects. It has been previously demonstrated that resveratrol exerts its biological effects primarily via sirtuin 1 (SIRT1) activation. We previously reported that triiodothyronine (T3) induces osteocalcin synthesis in osteoblast‑like MC3T3‑E1 cells, and that p38 mitogen‑activated protein (MAP) kinase mediates the T3‑stimulated synthesis of osteocalcin...
June 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28638763/the-hidden-face-of-wine-polyphenol-polymerization-highlighted-by-high-resolution-mass-spectrometry
#6
Anna Vallverdú-Queralt, Emmanuelle Meudec, Matthias Eder, Rosa M Lamuela-Raventos, Nicolas Sommerer, Véronique Cheynier
Polyphenols, including tannins and red anthocyanin pigments, are responsible for the color, taste, and beneficial health properties of plant-derived foods and beverages, especially in red wines. Known compounds represent only the emerged part of the "wine polyphenol iceberg". It is believed that the immersed part results from complex cascades of reactions involving grape polyphenols and yeast metabolites. We used a non-targeted strategy based on high-resolution mass spectrometry and Kendrick mass defect plots to explore this hypothesis...
June 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28610729/targeted-and-untargeted-high-resolution-mass-approach-for-a-putative-profiling-of-glycosylated-simple-phenols-in-hybrid-grapes
#7
Chiara Barnaba, Eduardo Dellacassa, Giorgio Nicolini, Mattia Giacomelli, Tomas Roman Villegas, Tiziana Nardin, Roberto Larcher
Vitis vinifera is one of the most widespread grapevines around the world representing the raw material for high quality wine production. The availability of more resistant interspecific hybrid vine varieties, developed from crosses between Vitis vinifera and other Vitis species, has generated much interest, also due to the low environmental effect of production. However, hybrid grape wine composition and varietal differences between interspecific hybrids have not been well defined, particularly for the simple phenols profile...
August 2017: Food Research International
https://www.readbyqxmd.com/read/28606222/association-of-flavonoid-rich-foods-and-flavonoids-with-risk-of-all-cause-mortality
#8
Kerry L Ivey, Majken K Jensen, Jonathan M Hodgson, A Heather Eliassen, Aedín Cassidy, Eric B Rimm
Flavonoids are bioactive compounds found in foods such as tea, red wine, fruits and vegetables. Higher intakes of specific flavonoids, and flavonoid-rich foods, have been linked to reduced mortality from specific vascular diseases and cancers. However, the importance of flavonoid-rich foods, and flavonoids, in preventing all-cause mortality remains uncertain. As such, we examined the association of intake of flavonoid-rich foods and flavonoids with subsequent mortality among 93 145 young and middle-aged women in the Nurses' Health Study II...
May 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28521683/impact-of-red-wine-consumption-on-cardiovascular-health
#9
Luca Liberale, Aldo Bonaventura, Fabrizio Montecucco, Franco Dallegri, Federico Carbone
The devastating effects of heavy alcohol drinking have been long time recognized. In the last decades, potential benefits of modest red wine drinking were suggested. In European countries in which red wide intake is not negligible (such as France), the association between cholesterol and cardiovascular (CV) risk was less evident, suggesting the action of some protective molecules in red wine or other foods and drinks. Epidemiological and mechanistic evidence of a J-shaped relationship between red wine intake and CV risk further supported the "French paradox"...
May 17, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28482835/mechanism-of-resveratrol-induced-relaxation-in-the-human-gallbladder
#10
Ching-Chung Tsai, Ming-Che Lee, Shu-Leei Tey, Ching-Wen Liu, Shih-Che Huang
BACKGROUND: Resveratrol is a polyphenolic compound extracted from plants and is also a constituent of red wine. Resveratrol produces relaxation of vascular smooth muscle and may prevent cardiovascular diseases. Although resveratrol has been reported to cause relaxation of the guinea pig gallbladder, limited data are available about the effect of resveratrol on the gallbladder smooth muscle in humans. The purpose of this study was to investigate the relaxation effects of resveratrol in human gallbladder muscle strips...
May 8, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28471493/effects-of-vinification-techniques-combined-with-uv-c-irradiation-on-phenolic-contents-of-red-wines
#11
Hande Tahmaz, Gökhan Söylemezoğlu
Red wines are typically high in phenolic and antioxidant capacity and both of which can be increased by vinification techniques. This study employed 3 vinification techniques to assess the increase in phenolic compounds and antioxidant capacity. Wines were obtained from Boğazkere grape cultivar by techniques of classical maceration, cold maceration combined with ultraviolet light (UV) irradiation, and thermovinification combined with UV irradiation and changes in phenolic contents were examined. Total phenolic and anthocyanin contents and trolox equivalent antioxidant capacity of wines were measured spectrophotometrically and phenolic contents (+)-catechin, (-)-epicatechin, rutin, quercetin, trans-resveratrol, and cis-resveratrol were measured by High Pressure Liquid Chromatography with Diode Array Detection (HPLC-DAD)...
June 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28452954/hydroxytyrosol-and-cytoprotection-a-projection-for-clinical-interventions
#12
REVIEW
Francisca Echeverría, Macarena Ortiz, Rodrigo Valenzuela, Luis A Videla
Hydroxytyrosol (HT) ((3,4-Dihydroxyphenyl)ethanol) is a polyphenol mainly present in extra virgin olive oil (EVOO) but also in red wine. It has a potent antioxidant effect related to hydrogen donation, and the ability to improve radical stability. The phenolic content of olive oil varies between 100 and 600 mg/kg, due to multiple factors (place of cultivation, climate, variety of the olive and level of ripening at the time of harvest), with HT and its derivatives providing half of that content. When consumed, EVOO's phenolic compounds are hydrolyzed in the stomach and intestine, increasing levels of free HT which is then absorbed in the small intestine, forming phase II metabolites...
April 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28436828/sensory-profile-and-volatile-aroma-composition-of-reduced-alcohol-merlot-wines-fermented-with-metschnikowia-pulcherrima-and-saccharomyces-uvarum
#13
C Varela, A Barker, T Tran, A Borneman, C Curtin
Strategies for production of wines containing lower alcohol concentrations are in strong demand, for reasons of quality, health, and taxation. Development and application of wine yeasts that are less efficient at transforming grape sugars into ethanol has the potential to allow winemakers the freedom to make lower alcohol wines from grapes harvested at optimal ripeness, without the need for post-fermentation processes aimed at removing ethanol. We have recently shown that two non-conventional wine yeast species Metschnikowia pulcherrima and Saccharomyces uvarum were both able to produce wine with reduced alcohol concentration...
April 12, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28402662/dominant-carbons-in-trans-and-cis-resveratrol-isomerization
#14
Feng Wang, Subhojyoti Chatterjee
A comprehensive analysis for isomerization of geometric isomers in the case of resveratrol (R) has been presented. As an important red wine molecule, only one geometric isomer of resveratrol, i.e., trans-R rather than cis-R, is primarily associated with health benefit. In the present study, density function theory (DFT) provides accurate descriptions of isomerization of resveratrol. The nearly planar trans-R forms a relatively rigid and less flexible conjugate network, but the nonplanar cis-R favors a more flexible structure with steric through space interaction...
May 11, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28393974/-origin-components-and-mechanisms-of-action-of-the-mediterranean-diet
#15
Inés Urquiaga, Guadalupe Echeverría, Catalina Dussaillant, Attilio Rigotti
The Mediterranean diet is currently considered a healthy dietary pattern. It includes a great variety of foods, which are eaten in moderation and within a positive social environment. The generic term "Mediterranean diet" was born after the "Seven Countries Study" led by Ancel Keys around 1960. This dietary pattern is characterized by a high intake of fruits and vegetables, whole grains, legumes, nuts, fish, white meats and olive oil. It also includes moderate consumption of fermented dairy products, low intake of red meat and drinking wine with moderation during meals...
January 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28372244/antioxidant-capacity-of-phenolic-compounds-on-human-cell-lines-as-affected-by-grape-tyrosinase-and-botrytis-laccase-oxidation
#16
Matthias Riebel, Andrea Sabel, Harald Claus, Ning Xia, Huige Li, Helmut König, Heinz Decker, Petra Fronk
Phenolic components (PCs) are well-known for their positive impact on human health. In addition to their action as radical scavengers, they act as activators for the intrinsic cellular antioxidant system. Polyphenol oxidases (PPOs) such as tyrosinase and laccase catalyze the enzymatic oxidation of PCs and thus, can alter their scavenging and antioxidative capacity. In this study, oxidation by tryosinase was shown to increase the antioxidant capacity of many PCs, especially those that lack adjacent aromatic hydroxyl groups...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28338616/a-comparative-study-of-phenols-in-apulian-italian-wines
#17
Andrea Ragusa, Carla Centonze, Maria E Grasso, Maria F Latronico, Pier F Mastrangelo, Federica Sparascio, Francesco P Fanizzi, Michele Maffia
Nutraceutics is a growing research field in which researchers study and attempt to improve the biological properties of metabolites in food. Wine is one of the most consumed products in the world and contains a plethora of molecules biologically relevant to human health. In this article, several polyphenols with potential antioxidant activity were measured in wines from Apulia, in Southeast Italy. Hydroxytyrosol, gallic and syringic acids, luteolin, quercetin, and trans-resveratrol were identified and quantified by HPLC...
March 24, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28318567/determination-of-ochratoxin-a-in-wine-by-packed-in-tube-solid-phase-microextraction-followed-by-high-performance-liquid-chromatography-coupled-to-tandem-mass-spectrometry
#18
Mariane A Andrade, Fernando M Lanças
Ochratoxin A (OTA), a widely studied mycotoxin, can be found in a variety of food matrices. As its concentration in food is generally low (in the order of μg kg(-1)), sample preparation techniques are necessary for the analyte purification and pre-concentration in order to achieve the required low detection limits. The separation and detection methods used for OTA analysis should also offer proper sensitivity in order to allow the adequate quantification of the analyte. This manuscript addresses the development of a methodology aiming the analysis of OTA in wine samples by packed in-tube SPME in flow through extraction mode coupled to HPLC-MS/MS...
April 14, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28278676/comparative-analytical-study-of-the-selected-wine-varieties-grown-in-montenegro
#19
Neda O Đorđević, Miroslav M Novaković, Boris Pejin, Jelena J Mutić, Vlatka E Vajs, Snežana B Pajović, Vele V Tešević
Samples of the selected red wine varieties grown in Montenegro (Merlot, Cabernet Sauvignon and Vranac; vintages 2010-2012) were compared according to total phenolic content, anti-DPPH radical activity, phenolic profile and elemental composition. All the samples showed profound anti-DPPH radical activity, due to high content of total phenolic compounds (R = 0.92). The most abundant phenolics were catechin and gallic acid with the highest values recorded for Merlot 2012 (43.22 and 28.65 mg/L, respectively)...
February 13, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28272361/a-focused-multiple-reaction-monitoring-mrm-quantitative-method-for-bioactive-grapevine-stilbenes-by-ultra-high-performance-liquid-chromatography-coupled-to-triple-quadrupole-mass-spectrometry-uhplc-qqq
#20
Elías Hurtado-Gaitán, Susana Sellés-Marchart, Ascensión Martínez-Márquez, Antonio Samper-Herrero, Roque Bru-Martínez
Grapevine stilbenes are a family of polyphenols which derive from trans-resveratrol having antifungal and antimicrobial properties, thus being considered as phytoalexins. In addition to their diverse bioactive properties in animal models, they highlight a strong potential in human health maintenance and promotion. Due to this relevance, highly-specific qualitative and quantitative methods of analysis are necessary to accurately analyze stilbenes in different matrices derived from grapevine. Here, we developed a rapid, sensitive, and specific analysis method using ultra-high-performance liquid chromatography coupled to triple-quadrupole mass spectrometry (UHPLC-QqQ) in MRM mode to detect and quantify five grapevine stilbenes, trans-resveratrol, trans-piceid, trans-piceatannol, trans-pterostilbene, and trans-ε-viniferin, whose interest in relation to human health is continuously growing...
March 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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