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Yong-Chin Lin, Jiann-Chu Chen, Yu-Yuan Chen, Su-Tuen Yeh, Li-Li Chen, Chien-Lun Huang, Jen-Fang Hsieh, Chang-Che Li
Immunity parameters and the expression levels of several immune-related proteins, including lipopolysaccharide and β-glucan binding protein (LGBP), peroxinectin (PX), intergin β (IB), prophenoloxidase (proPO) I, proPO II, α2-macroglobulin (α2-M), cytosolic mangangese superoxide dismutase (cytMnSOD), mitochondria manganese superoxide dismutase (mtMnSOD), catalase, glutathione peroxidase (GPx), lysozyme, and penaeidin 3a were examined in white shrimp Litopenaeus vannamei reared at stocking densities of 2, 10, 20, 30, and 40 shrimp L(-1) after 3, 6, and 12 h...
July 2015: Fish & Shellfish Immunology
Petros A Kokkinos, Petros G Koutsoukos, Despina D Deligianni
Hydroxyapatite (HA) has been widely used as a bone substitute in dental, maxillofacial and orthopaedic surgery and as osteoconductive bone substitute or precoating of pedicle screws and cages in spine surgery. The aim of the present study was to investigate the osteoblastic adhesion strength on HA substrata with different surface topography and biochemistry (pre-adsorption of fibronectin) after blocking of specific integrin subunits with monoclonal antibodies. Stoichiometric HA was prepared by precipitation followed by ageing and characterized by SEM, EDX, powder XRD, Raman spectroscopy, TGA, and specific surface area analysis...
June 2012: Journal of Materials Science. Materials in Medicine
Man-Hui Pai, Yi-Wen Chien, Ya-Hui Tsai, Ya-Mei Hu, Sung-Ling Yeh
Chronic arsenic exposure results in an increased oxidative stress and inflammation in the body. Glutamine (GLN) is an amino acid considered to have immunomodulatory effects and attenuate the inflammatory reaction. This study was designed to examine the effect of GLN supplementation on inflammatory-related leukocyte integrin expression and in vitro splenocyte cytokine production in mice exposed to arsenic. Mice were assigned to the control and experimental groups. The control group drank deionized water, whereas the experimental group drank deionized water containing 50 ppm of sodium arsenite...
August 2008: Nutrition Research
Monika Gramann, Olaf Wendler, Lothar Haeberle, Bernhard Schick
The extracellular matrix component collagen type VI demonstrates potent growth-stimulatory effects and has been associated with aggressive tumour growth. Although, juvenile angiofibromas (JAs) often exhibit an aggressive growth pattern, the collagen type VI expression of this fibrovascular tumour has not been addressed so far. RT-PCR, Western blot analysis and immunohistochemistry were used in this study to analyse collagen type VI, type VI collagen receptor subunits (integrin alpha1, alpha2, alpha10, alpha11 and beta1) and the type VI collagen receptor NG2 in JAs (N = 15) and nasal mucosa (NM, N = 8) samples...
January 2009: Histochemistry and Cell Biology
W El Nemer, E Gauthier, M-P Wautier, C Rahuel, P Gane, F Galactéros, J-L Wautier, J-P Cartron, Y Colin, C Le Van Kim
Lutheran (Lu) blood group and Basal Cell Adhesion Molecule (BCAM) antigens are both carried by two glycoprotein (gp) isoforms of the immunoglobulin superfamily representing receptors for laminin alpha5 chain. They are expressed in red blood cells, in endothelial cells of vascular capillaries and in epithelial cells of several tissues. Lu/BCAM gps are overexpressed in sickle red blood cells (SS RBCs). Stimulation of SS RBCs by epinephrine activates the PKA depending signaling pathway and induces reinforced Lu/BCAM-mediated adhesion to laminin10/11...
February 2008: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
Yu-Jing Fang, De-Sen Wan
The morbidity and mortality of colorectal cancer are increasing over the world, while liver metastasis is the main cause of death. Many studies have elucidated the mechanisms. We searched the key words, such as colorectal cancer, liver metastasis and molecular factors, through PubMed, Medline and National Knowledge Infrastructure CNKI literature searching system, and discussed the studies in the recent decade. Thirteen well-identified and elucidated molecular factors, which belong to 8 categories, including matrix metalloproteinases, urokinase plasminogen activator receptor, intergin, osteopontin, tumor necrosis factor-related apoptosis-inducing ligand, interferon-beta, insulin-like growth factor receptor 1, nuclear matrix protein, vascular endothelial growth factor, peroxisome proliferator-activated receptor-gamma, insulin-like growth factor, extracellular signal-regulated protein kinase and proteinase-activated receptors were reviewed in the article...
May 2008: Ai Zheng, Aizheng, Chinese Journal of Cancer
Hans-J Welkoborsky, Roland S Jacob, Mike L Hinni
In the clinical setting, pediatric cholesteatomas frequently behave more aggressively than similar lesions in adults. The reason for the difference in behavior is still unclear. The purpose of the present study was to investigate the cell to cell and epithelial-stroma interaction of acquired cholesteatoma in adults and children and search for differences on the cellular level, which might explain the different behavior of these lesions. Operative specimens of 54 patients [40 adults (average age of 39.7 years), 14 children (average age of 8...
August 2007: European Archives of Oto-rhino-laryngology
G E Morozevich, N I Kozlova, M E Preobrazhenskaya, N A Ushakova, I A Eltsov, A A Shtil, A E Berman
Integrin expression was investigated in MCF-7 human breast adenocarcinoma line and in the MCF-7Dox line, which was selected from MCF-7 by a resistance to multiple antitumor drugs (MDR). We have shown that acquisition of MDR was accompanied by a drastically reduced expression of some integrins of the beta1-subfamily (alpha2beta1, alpha3beta1, alpha6beta1) and of alpha vbeta5 intergin in the adenocarcinoma cells. In contrast, expression of alpha5beta1 integrin was markedly increased in the MDR cells. Along with multiple antitumor drug resistance, MCF-7Dox cells demonstrate elevated resistance to anchorage-dependent apoptosis (anoikis) and enhanced in vitro invasive activity...
May 2006: Biochemistry. Biokhimii︠a︡
Cezary Kowalewski, Anna Kozłowska, Marta Górska, Katarzyna Woźniak, Maciej Krajewski, Maria Błaszczyk, Stefania Jabłońska
The aim of this study was to compare alterations of the basement membrane zone (BMZ) and to visualize changes within the skin vascular network in morphea and extragenital lichen sclerosus with the use of laser scanning confocal microscopy. This work was performed in eight plaques of morphea (three active and five inactive) and eight of lichen sclerosus (three of short duration and five long-lasting). Biopsy specimens from six healthy individuals served as controls. The biopsies were cut into 40-microm-thick sections, labeled with antibodies against beta4-intergin (a lamina lucida marker), collagen IV, and the N-terminal end of collagen VII (lamina densa markers) and C-terminal end of collagen VII (a sublamina densa marker) and studied using laser scanning confocal microscopy...
December 2005: American Journal of Dermatopathology
A Barry Kay, Simon Phipps, Douglas S Robinson
Over the years, the role of the eosinophil in asthma and allergic processes has been disputed. Recent human experiments using a humanised monoclonal antibody to interleukin-5 (IL-5), and animal studies involving specific IL-5 gene deletion, indicates that eosinophils might control downstream repair and remodelling processes. Eosinophils are a rich source of fibrogenic factors, particularly transforming growth factor-beta (TGF-beta), the latent form of which is activated by epithelial-cell expression of the intergin alpha(v)beta(6)...
September 2004: Trends in Immunology
Cezary Kowalewski, Anna Kozlowska, Marta Zawadzka, Katarzyna Woźniak, Maria Blaszczyk, Stefania Jablońska
The aim of the study was to compare alterations of various regions of the basement membrane zone (BMZ) in lichen sclerosus (LS) using laser scanning confocal microscopy. The study included three cases of bullous LS, one case of bullous LS that developed in the course of graft-versus-host disease (GVHD), and six cases of non-bullous LS. Three cases of morphea served as a control. Biopsies from patients' skin and control biopsies from normal human skin were cut into 30-microm thick slides and labeled with antibodies against beta4-intergin (lamina lucida marker), collagen IV, and the N-terminal end of collagen VII (lamina densa markers) and the C-terminal end of collagen VII (sublamina densa marker) using routine immunofluorescence (IF)...
April 2004: American Journal of Dermatopathology
F R Maxfield
Neutrophils migrate towards sites of inflammation and infection by chemotaxis. Their motility is dependent on the actin cytoskeleton and on adhesion to extracellular substrates, but how these are regulated in response to stimuli is not clear. This review focuses on the potential role of Ca(2+) as a second messenger in neutrophil motility. Several effects of Ca(2+) and Ca(2+)-binding proteins on the stability and crosslinking of actin polymers have been demonstrated in vitro. Nevertheless, the complex mechanism by which Ca(2+) regulates actin in neutrophils is not fully understood...
November 1993: Trends in Cell Biology
S Duensing, A Duensing, J Grosse, J Atzpodien
Expression of P-glycoprotein (P-gp) mediated multidrug resistance (MDR) has been suggested to be associated with an impaired clinical outcome in several malignancies. In contrast to P-gp itself, further phenotypical and functional alterations related to MDR are poorly characterized. In this in vitro study, we analyzed two Burkitt's lymphoma cell lines (Raji and Daudi) for the beta 1 integrin phenotype prior to and after induction of MDR via co-cultivation with vincristine. A significant loss of the VLA-3 (CD49c/CD29) adhesion receptor was observed whereas all other intergins analyzed lacked considerable changes...
October 1998: Cancer Biotherapy & Radiopharmaceuticals
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