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https://www.readbyqxmd.com/read/28097172/transcript-levels-of-phytoene-desaturase-gene-in-dunaliella-salina-teod-as-affected-by-pbs-nanoparticles-and-light-intensity
#1
Hajar Zamani, Ali Moradshahi
Phytoene synthase (Psy) and Phytoene desaturase (Pds) are the first two regulatory enzymes in the carotenoids biosynthetic pathway. The genes Psy and Pds are under transcriptional control in many photosynthetic organisms. In the present study, using quantitative real time- PCR (qRT-PCR), the effects of uncoated and gum-Arabic coated PbS nanoparticles (GA-coated PbS NPs) and light intensity on the mRNA levels of Pds were investigated. Relative to mRNA level of Pds at 100 µmol photon m-2 s-1 light intensity (control culture), 2...
September 2016: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/28069021/preoperative-optimization-of-patient-expectations-improves-long-term-outcome-in-heart-surgery-patients-results-of-the-randomized-controlled-psy-heart-trial
#2
Winfried Rief, Meike C Shedden-Mora, Johannes A C Laferton, Charlotte Auer, Keith J Petrie, Stefan Salzmann, Manfred Schedlowski, Rainer Moosdorf
BACKGROUND: Placebo effects contribute substantially to outcome in most fields of medicine. While clinical trials typically try to control or minimize these effects, the potential of placebo mechanisms to improve outcome is rarely used. Patient expectations about treatment efficacy and outcome are major mechanisms that contribute to these placebo effects. We aimed to optimize these expectations to improve outcome in patients undergoing coronary artery bypass graft (CABG) surgery. METHODS: In a prospective three-arm randomized clinical trial with a 6 month follow-up, 124 patients scheduled for CABG surgery were randomized to either a brief psychological pre-surgery intervention to optimize outcome expectations (EXPECT); or a psychological control intervention focusing on emotional support and general advice, but not on expectations (SUPPORT); or to standard medical care (SMC)...
January 10, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28063395/differences-in-social-functioning-among-patients-with-major-psychiatric-disorders-interpersonal-communication-is-impaired-in-patients-with-schizophrenia-and-correlates-with-an-increase-in-schizotypal-traits
#3
Toshiki Yasuyama, Kazutaka Ohi, Takamitsu Shimada, Takashi Uehara, Yasuhiro Kawasaki
Impaired social functioning is a hallmark of major psychiatric disorders. The purpose of this study was to detect a disorder-specific factor of social dysfunction among patients with major psychiatric disorders (PSY), including schizophrenia (SCZ), bipolar disorder (BIP) and major depressive disorder (MDD). Social functioning was assessed in patients with SCZ (n=80), BIP (n=27) or MDD (n=29) and healthy controls (HC, n=68) using the Social Functioning Scale (SFS). Compared to HC, the SCZ, BIP and MDD patient groups showed lower total SFS scores...
December 31, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28040679/morphological-observation-rna-seq-quantification-and-expression-profiling-novel-insight-into-grafting-responsive-carotenoid-biosynthesis-in-watermelon-grafted-onto-pumpkin-rootstock
#4
Guang Liu, Xingping Yang, Jinhua Xu, Man Zhang, Qian Hou, Lingli Zhu, Ying Huang, Aisheng Xiong
Watermelon is an important and economical horticultural crop in China, where ~20% of the plants are grafted. The development of grafted watermelon fruit involves a diverse range of gene interactions that results in dynamic changes in fruit. However, the molecular mechanisms underlying grafting-induced fruit quality change are unclear. In the present study, we measured the lycopene content by high-performance liquid chromatography and used RNA-Seq (quantification) to perform a genome-wide transcript analysis of fruits from watermelon grafted onto pumpkin rootstock (pumpkin-grafted watermelon, PGW), self-grafted watermelon (SGW), and non-grafted watermelon (NGW)...
December 30, 2016: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/27930478/prospective-impact-of-psychiatric-disorders-on-employment-status-and-health-care-use-in-patients-investigated-for-occupational-asthma
#5
Kim L Lavoie, Helene Favreau, Nicola J Paine, Catherine Lemière, Maryann Joseph, Avril Gagnon-Chauvin, André Cartier, Simon L Bacon
OBJECTIVE: We previously reported high rates (34%) of psychiatric disorders (PSY) in patients evaluated for occupational asthma (OA). We determined the impact of PSY on employment status and health care use 12 to 18 months later. METHODS: One hundred ninety-six patients underwent clinical and psychiatric interviews on the day of their OA evaluation. Patients were re-contacted 12to 18 months later to assess employment status and health care use. RESULTS: Results indicated that patients with a PSY at baseline were less likely to be employed (adjusted odds ratio = 2...
December 2016: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27925772/which-domain-of-the-psy-5-is-most-relevant-to-substance-use
#6
William T Bryant, John L McNulty
Substance use has generally been related to lower levels of agreeableness and conscientiousness, but has evidenced relationships with other personality trait domains as well, including impulsivity. This study was conducted to determine which trait domain of personality is most related to substance use from the perspective of the Personality Psychopathology Five model (Harkness & McNulty, 1994 ). Archival data were used from 2 clinical settings: 1 outpatient community mental health center and 1 inpatient Veteran's Affairs hospital...
December 7, 2016: Journal of Personality Assessment
https://www.readbyqxmd.com/read/27891167/effect-on-body-weight-and-composition-in-overweight-obese-australian-adults-over-12%C3%A2-months-consumption-of-two-different-types-of-fibre-supplementation-in-a-randomized-trial
#7
Sebely Pal, Suleen Ho, Roland J Gahler, Simon Wood
BACKGROUND/OBJECTIVES: Higher fibre intakes are associated with risk reduction for chronic diseases. However, many people find difficulty in consuming sufficient fibre through their diet. Supplements may be an effective alternative. We aimed to investigate the effects of PolyGlycopleX® (PGX®), a proprietary polysaccharide complex and a proprietary Psyllium product (PgxSyl™) (PSY) on diet, body weight and composition in overweight and obese individuals. SUBJECTS/METHODS: This was a double-blind 52 weeks study with 159 people randomized to 3 groups: control (rice flour); PGX (PGX) and proprietary psyllium (PSY)...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27853460/pre-sowing-seed-treatment-with-24-epibrassinolide-ameliorates-pesticide-stress-in-brassica-juncea-l-through-the-modulation-of-stress-markers
#8
Anket Sharma, Sharad Thakur, Vinod Kumar, Mukesh K Kanwar, Anup K Kesavan, Ashwani K Thukral, Renu Bhardwaj, Pravej Alam, Parvaiz Ahmad
The present experiment was designed to assess the effects of seed soaking with 24-epibrassinolide (EBR) on the physiology of Brassica juncea L. seedlings grown under imidacloprid (IMI) toxicity. Application of EBR increased the length of seedlings, dry weight, and pigment contents, polyphenols, total phenols, and organic acids under IMI toxicity. The expression of genes coding key enzymes of pigment, phenols, polyphenols, and organic acid biosynthetic pathways was also studied including CHLASE (chlorophyllase), PSY (phytoene synthase), CHS (chalcone synthase) and PAL (phenylalanine ammonialyase), CS (citrate synthase), SUCLG1 (succinyl Co-A ligase,), SDH (succinate dehydrogenase), FH (fumarate hydratase), MS (malate synthase)...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27853356/body-image-discrepancy-and-subjective-norm-as-mediators-and-moderators-of-the-relationship-between-body-mass-index-and-quality-of-life
#9
Benoit Pétré, André J Scheen, Olivier Ziegler, Anne-Françoise Donneau, Nadia Dardenne, Eddy Husson, Adelin Albert, Michèle Guillaume
BACKGROUND AND OBJECTIVE: Despite the strength and consistency of the relationship between body mass index (BMI) and quality of life (QoL), a reduction in BMI does not necessarily lead to an improvement in QoL. Between-subject variability indicates the presence of mediators and moderators in the BMI-QoL association. This study aimed to examine the roles of body image discrepancy (BID) and subjective norm (SN) as potential mediators and moderators. SUBJECTS AND METHODS: In 2012, 3,016 volunteers (aged ≥18 years) participated in a community-based survey conducted in the French-speaking region of Belgium...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27837090/distinct-mechanisms-of-the-orange-protein-in-controlling-carotenoid-flux
#10
Noam Chayut, Hui Yuan, Shachar Ohali, Ayala Meir, Uzi Sa'ar, Galil Tzuri, Yi Zheng, Michael Mazourek, Shimon Gepstein, Xiangjun Zhou, Vitaly Portnoy, Efraim Lewinsohn, Arthur A Schaffer, Nurit Katzir, Zhangjun Fei, Ralf Welsch, Li Li, Joseph Burger, Yaakov Tadmor
β-Carotene adds nutritious value and determines the color of many fruits, including melon (Cucumis melo). In melon mesocarp, β-carotene accumulation is governed by the Orange gene (CmOr) golden single-nucleotide polymorphism (SNP) through a yet to be discovered mechanism. In Arabidopsis (Arabidopsis thaliana), OR increases carotenoid levels by posttranscriptionally regulating phytoene synthase (PSY). Here, we identified a CmOr nonsense mutation (Cmor-lowβ) that lowered fruit β-carotene levels with impaired chromoplast biogenesis...
January 2017: Plant Physiology
https://www.readbyqxmd.com/read/27733008/-outpatient-psychotherapy-under-naturalistic-conditions-a-selective-review-of-results-from-german-speaking-countries
#11
Uwe Altmann, Désirée Thielemann, Bernhard Strauß
There is a growing body of literature recognizing the importance of outpatient psychotherapy. Several studies investigated the efficacy of outpatient psychotherapy and aspects of the health care system under natural conditions. This paper gives an overview of studies from German speaking countries (TRANS-OP-, TK-, PAP-S- and QS-PSY-BAY-study).The results of the different studies indicate both, positive outcome of the therapies (e. g., reduction of symptoms with an average ES of 1,03; improvement of symptoms despite premature termination) as well as an economic benefit (end of treatment depending on treatment outcome and not limited by therapy sessions; extensions of psychotherapy only if patient is highly impaired and therapeutic alliance is positive; high reduction of supply costs and sick leave)...
October 2016: Psychiatrische Praxis
https://www.readbyqxmd.com/read/27729470/carotenogenesis-is-regulated-by-5-utr-mediated-translation-of-phytoene-synthase-splice-variants
#12
Daniel Álvarez, Björn Voß, Dirk Maass, Florian Wüst, Patrick Schaub, Peter Beyer, Ralf Welsch
Phytoene synthase (PSY) catalyzes the highly regulated, frequently rate-limiting synthesis of the first biosynthetically formed carotene. While PSY constitutes a small gene family in most plant taxa, the Brassicaceae, including Arabidopsis (Arabidopsis thaliana), predominantly possess a single PSY gene. This monogenic situation is compensated by the differential expression of two alternative splice variants (ASV), which differ in length and in the exon/intron retention of their 5'UTRs. ASV1 contains a long 5'UTR (untranslated region) and is involved in developmentally regulated carotenoid formation, such as during deetiolation...
December 2016: Plant Physiology
https://www.readbyqxmd.com/read/27695116/characterization-and-expression-analysis-of-phytoene-synthase-from-bread-wheat-triticum-aestivum-l
#13
Flowerika, Anshu Alok, Jitesh Kumar, Neha Thakur, Ashutosh Pandey, Ajay Kumar Pandey, Santosh Kumar Upadhyay, Siddharth Tiwari
Phytoene synthase (PSY) regulates the first committed step of the carotenoid biosynthetic pathway in plants. The present work reports identification and characterization of the three PSY genes (TaPSY1, TaPSY2 and TaPSY3) in wheat (Triticum aestivum L.). The TaPSY1, TaPSY2, and TaPSY3 genes consisted of three homoeologs on the long arm of group 7 chromosome (7L), short arm of group 5 chromosome (5S), and long arm of group 5 chromosome (5L), respectively in each subgenomes (A, B, and D) with a similarity range from 89% to 97%...
2016: PloS One
https://www.readbyqxmd.com/read/27638607/lithium-improves-cell-viability-in-psychosine-treated-mo3-13-human-oligodendrocyte-cell-line-via-autophagy-activation
#14
Ambra Del Grosso, Sara Antonini, Lucia Angella, Ilaria Tonazzini, Giovanni Signore, Marco Cecchini
Globoid cell leukodystrophy (GLD) is a rare, rapidly progressing childhood leukodystrophy triggered by deficit of the lysosomal enzyme galactosylceramidase (GALC) and characterized by the accumulation of galactosylsphingosine (psychosine; PSY) in the nervous system. PSY is a cytotoxic sphingolipid, which leads to widespread degeneration of oligodendrocytes and Schwann cells, causing demyelination. Here we report on autophagy in the human oligodendrocyte cell line MO3.13 treated with PSY and exploitation of Li as an autophagy modulator to rescue cell viability...
November 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27638594/can-psychosine-and-galactocerebrosidase-activity-predict-early-infantile-krabbe-s-disease-presymptomatically
#15
Randy L Carter, Lawrence Wrabetz, Kabir Jalal, Joseph J Orsini, Amy L Barczykowski, Dietrich Matern, Thomas J Langan
Krabbe's disease (KD) is a fatal neurodegenerative disorder, with the early-infantile form (EIKD) defined by onset of symptoms before age 6 months. Early and highly accurate identification of EIKD is required to maximize benefits of hematopoietic stem cell transplantation treatment. This study investigates the potential for accurate prediction of EIKD based on a novel newborn screening (NBS) tool developed from two biomarkers, galactocerebrosidase (GALC) enzyme activity and galactosylsphingosine concentration (psychosine [PSY])...
November 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27638584/biochemical-cell-biological-pathological-and-therapeutic-aspects-of-krabbe-s-disease
#16
REVIEW
Je-Seong Won, Avtar K Singh, Inderjit Singh
Krabbe's disease (KD; also called globoid cell leukodystrophy) is a genetic disorder involving demyelination of the central (CNS) and peripheral (PNS) nervous systems. The disease may be subdivided into three types, an infantile form, which is the most common and severe; a juvenile form; and a rare adult form. KD is an autosomal recessive disorder caused by a deficiency of galactocerebrosidase activity in lysosomes, leading to accumulation of galactoceramide and neurotoxic galactosylsphingosine (psychosine [PSY]) in macrophages (globoid cells) as well as neural cells, especially in oligodendrocytes and Schwann cells...
November 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27633588/orange-protein-has-a-role-in-phytoene-synthase-stabilization-in-sweetpotato
#17
Seyeon Park, Ho Soo Kim, Young Jun Jung, Sun Ha Kim, Chang Yoon Ji, Zhi Wang, Jae Cheol Jeong, Haeng-Soon Lee, Sang Yeol Lee, Sang-Soo Kwak
Carotenoids have essential roles in light-harvesting processes and protecting the photosynthetic machinery from photo-oxidative damage. Phytoene synthase (PSY) and Orange (Or) are key plant proteins for carotenoid biosynthesis and accumulation. We previously isolated the sweetpotato (Ipomoea batatas) Or gene (IbOr), which is involved in carotenoid accumulation and salt stress tolerance. The molecular mechanism underlying IbOr regulation of carotenoid accumulation was unknown. Here, we show that IbOr has an essential role in regulating IbPSY stability via its holdase chaperone activity both in vitro and in vivo...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27604971/a-gender-responsive-treatment-facility-in-correctional-services-the-development-of-psychological-gymnasium-for-women-offenders
#18
Vivian W M Mak, Samuel M Y Ho, Regina W Y Kwong, W L Li
With increasing evidence suggesting a disparity in female and male offenders in terms of rehabilitative needs, growing concern has been placed on the development of gender-specific services for female offenders. As such, a prison-based psychological gymnasium (PSY GYM), with distinctive features in integrating cognitive-behavioral and positive-psychology concepts to address female offenders' needs, was set up in 2011. The present study aims to introduce the concept as well as present findings to evaluate the overall effectiveness of PSY GYM...
September 7, 2016: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/27507492/transcriptional-regulation-of-lycopene-metabolism-mediated-by-rootstock-during-the-ripening-of-grafted-watermelons
#19
Qiusheng Kong, Jingxian Yuan, Lingyun Gao, Peng Liu, Lei Cao, Yuan Huang, Liqiang Zhao, Huifang Lv, Zhilong Bie
Rootstocks have comprehensive effects on lycopene accumulation in grafted watermelon fruits. However, little is known about lycopene metabolic regulation in grafted watermelon. To address this problem, parallel changes in lycopene contents and the expression of its metabolic genes were analyzed during the fruit ripening of nongrafted watermelon and watermelon grafted onto bottle gourd, pumpkin, and wild watermelon. Results showed that rootstocks mediated the transcriptional regulations of lycopene accumulation in different ways...
January 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27478648/sleep-spindles-characteristics-in-insomnia-sufferers-and-their-relationship-with-sleep-misperception
#20
Marie-Pier Normand, Patrick St-Hilaire, Célyne H Bastien
Cortical hyperarousal is higher in insomnia sufferers (INS) than in good sleepers (GS) and could be related to an alteration in sleep protection mechanisms, like reduced density or altered characteristics in sleep spindles. The deficient sleep protection mechanisms might in turn enhance underestimation of sleep. This study's objective was to document sleep spindles characteristics in INS compared with GS and to investigate their potential role in sleep consolidation and misperception. Seventeen individuals with paradoxical insomnia (PARA-I), 24 individuals with psychophysiological insomnia (PSY-I), and 29 GS completed four consecutive polysomnographic nights in laboratory...
2016: Neural Plasticity
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