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Microfracture

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https://www.readbyqxmd.com/read/29765426/current-therapeutic-strategies-for-stem-cell-based-cartilage-regeneration
#1
REVIEW
Yoojun Nam, Yeri Alice Rim, Jennifer Lee, Ji Hyeon Ju
The process of cartilage destruction in the diarthrodial joint is progressive and irreversible. This destruction is extremely difficult to manage and frustrates researchers, clinicians, and patients. Patients often take medication to control their pain. Surgery is usually performed when pain becomes uncontrollable or joint function completely fails. There is an unmet clinical need for a regenerative strategy to treat cartilage defect without surgery due to the lack of a suitable regenerative strategy. Clinicians and scientists have tried to address this using stem cells, which have a regenerative potential in various tissues...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29763358/bone-marrow-stimulation-technique-augmented-by-an-ultrapurified-alginate-gel-enhances-cartilage-repair-in-a-canine-model
#2
Rikiya Baba, Tomohiro Onodera, Masatake Matsuoka, Kazutoshi Hontani, Zenta Joutoku, Shinji Matsubara, Kentaro Homan, Norimasa Iwasaki
BACKGROUND: The optimal treatment for a medium- or large-sized cartilage lesion is still controversial. Since an ultrapurified alginate (UPAL) gel enhances cartilage repair in animal models, this material is expected to improve the efficacy of the current treatment strategies for cartilage lesions. HYPOTHESIS: The bone marrow stimulation technique (BMST) augmented by UPAL gel can induce hyaline-like cartilage repair. STUDY DESIGN: Controlled laboratory study...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29752207/a-cross-sport-comparison-of-performance-based-outcomes-of-professional-athletes-following-primary-microfracture-of-the-knee
#3
Michael S Schallmo, Sameer K Singh, Kathryn A Barth, Ryan D Freshman, Harry T Mai, Wellington K Hsu
BACKGROUND: The purpose of this study was to compare performance-based outcomes among professional athletes in four major North American sports following microfracture to treat symptomatic chondral defects of the knee. METHODS: Major League Baseball (MLB), National Basketball Association (NBA), National Football League (NFL), and National Hockey League (NHL) athletes who underwent primary unilateral microfracture of the knee were identified through a previously reported protocol based on public sources...
May 8, 2018: Knee
https://www.readbyqxmd.com/read/29736570/surgical-treatment-paradigms-of-ankle-lateral-instability-osteochondral-defects-and-impingement
#4
Hélder Pereira, Gwendolyn Vuurberg, Pietro Spennacchio, Jorge Batista, Pieter D'Hooghe, Kenneth Hunt, Niek Van Dijk
Ankle sprain is amongst the most frequent musculoskeletal injuries, particularly during sports activities. Chronic ankle instability (CAI) resulting from an ankle sprain might have severe long-lasting consequences on the ankle joint. Despite the fact that most patients will respond favourably to appropriate conservative treatment, around 20% will develop symptomatic CAI with sense of giving away and recurrent sprains leading to functional impairment. "Classical" surgical repair by Brostrom-like surgery in one of its many modifications has achieved good results over the years...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29731319/the-influence-of-tibial-slope-on-the-graft-in-combined-high-tibial-osteotomy-and-anterior-cruciate-ligament-reconstruction
#5
Philipp Schuster, Markus Geßlein, Michael Schlumberger, Philipp Mayer, Jörg Richter
BACKGROUND: Young patients with severe medial osteoarthritis, varus malalignment and insufficiency of the anterior cruciate ligament (ACL) are difficult to treat. The tibial slope has gained attention with regard to osteotomies and ligamentous instability. The purpose was to evaluate the outcome of combined high tibial osteotomy (HTO), ACL reconstruction and chondral resurfacing (CR, abrasion plus microfracture), and to analyse graft failure rates with regard to the tibial slope. METHODS: Fifty cases (48...
May 3, 2018: Knee
https://www.readbyqxmd.com/read/29729758/editorial-commentary-cell-based-therapy-for-treatment-of-chondral-lesions-of-the-patellofemoral-joint-using-particulated-juvenile-chondrocytes
#6
EDITORIAL
Samuel K Tabet
The potential of cell-based therapies to fill articular cartilage defects is no longer a "pipe dream." Filling an articular cartilage defect with at least a "mixed hyaline cartilage" repair is no longer a question. The task at hand is somehow refining and defining the when, where, what, and how of the cartilage-growing procedures. The new ideas emerging are reflected in the recent literature, and all ideas regarding the specifics of these cartilage techniques and their outcomes should be welcomed...
May 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29729026/longevity-of-bond-strength-of-resin-cements-to-root-dentine-after-radiation-therapy
#7
P A Yamin, R D Pereira, F C Lopes, A M Queiroz, H F Oliveira, P C Saquy, M D Sousa-Neto
AIM: To evaluate the bond strength and adhesive interface between several resin cements and root dentine immediately and after 6 months of radiotherapy protocol. METHODOLOGY: Sixty maxillary canines were selected and randomly assigned to two groups (n=30): one group was not irradiated, and the other one was subjected to a cumulative radiation dose of 60 Gy. The teeth were sectioned to obtain roots with 16 mm length, and the canals were prepared with Reciproc system (R50) and filled using a lateral condensation technique with epoxy resin sealer...
May 4, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29704023/radiological-analysis-of-cystic-lesion-in-osteonecrosis-of-the-femoral-head
#8
Fuqiang Gao, Jun Han, Zike He, Zirong Li
PURPOSE: Cystic lesions are a common complication in osteonecrosis of the femoral head (ONFH). This study will discuss the cause of cystic lesion formation and the feature of cystic lesion distribution in ONFH. According to the feature of cystic lesion in ONFH, we will discuss the possible mechanisms of cystic lesions and their  influence on collapse of the femoral head. MATERIALS AND METHODS: We retrospectively gathered 102 ONFH patients (168 hips) from November in 2015 to August in 2016 on China-Japan Friendship Hospital...
April 27, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29701070/the-role-of-3d-reconstruction-true-volume-analysis-in-osteochondral-lesions-of-the-talus-a-case-series
#9
Kempland C Walley, Tyler A Gonzalez, Ryan Callahan, Aubree Fairfull, Evan Roush, Kaitlin L Saloky, Paul J Juliano, Gregory S Lewis, Michael C Aynardi
BACKGROUND: Evaluation and management of osteochondral lesions of the talus (OLTs) often warrant advanced imaging studies, especially in revision or cases with cystic defects. It is possible that orthopedic surgeons may overestimate the size and misinterpret the morphology of OLT from conventional computed tomography (CT), thereby influencing treatment strategies. The purpose of this study was to determine the utility of a novel means to estimate the true-volume of OLTs using 3D reconstructed images and volume analysis...
April 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29698981/partial-hemiresurfacing-of-osteochondral-defects-of-the-talus-surgical-technique-and-preliminary-report-from-four-patient
#10
Sascha Beck, André Busch, Christoph Zilkens, Sebastian Warwas, Marcus Jäger
BACKGROUND: Osteochondral lesions of the medial talus (OLT) frequently lead to chronic ankle pain and osteoarthritis. Arthroscopic debridement, subchondral bone stimulation by drilling, and microfracturing are options for primary therapy in small lesions. In larger lesions, restoration of the talar dome contour seems to be a mandatory course of action. METHODS: In a case series, we followed up four patients being treated with a focal resurfacing prosthetic due to large osteochondral talar lesions...
April 26, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29697499/management-of-articular-cartilage-defects-in-the-glenohumeral-joint
#11
Adam J Seidl, Matthew J Kraeutler
Articular cartilage defects are not often encountered in the glenohumeral joint. These lesions are typically found in patients with shoulder trauma, recurrent instability, or previous surgical treatment. Diagnosis can be difficult; these defects are often found incidentally during arthroscopic or open surgical management of other pathology. Initial management of isolated glenohumeral chondral defects is nonsurgical and includes physical therapy and/or corticosteroid injections. If nonsurgical treatment is unsuccessful, patients may undergo surgery...
April 24, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29696318/microfracture-provides-better-clinical-results-than-debridement-in-the-treatment-of-acute-talar-osteochondral-lesions-using-arthroscopic-assisted-fixation-of-acute-ankle-fractures
#12
Altuğ Duramaz, Emre Baca
PURPOSE: Ankle arthroscopy is a useful tool for detection and treatment of accompanying intraarticular pathologies in acute ankle fractures. The purpose of this study was to compare the treatment results of talus osteochondral lesions (OLT) with debridement and microfracture in arthroscopy assisted surgery of acute ankle fractures. METHODS: Eleven consecutive patients who were treated with arthroscopic acute debridement and 14 consecutive patients who were treated with arthroscopic acute microfracture in the treatment of ankle fracture were included in the study...
April 25, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29678170/self-reported-functional-recovery-after-reconstruction-versus-repair-in-acute-anterior-cruciate-ligament-rupture-rotor-a-randomized-controlled-clinical-trial
#13
Barbara C Boer, Roy A G Hoogeslag, Reinoud W Brouwer, Anna Demmer, Rianne M H A Huis In 't Veld
BACKGROUND: Anterior cruciate ligament (ACL) reconstruction is today's surgical gold standard for ACL rupture. Although it provides satisfactory results, not all patients return to their previous activity level and moreover, early posttraumatic osteoarthritis is not prevented. As such, a renewed interest has emerged in ACL suture repair combined with dynamic augmentation. Compared to ACL reconstruction, the hypothesized advantages of ACL suture repair are earlier return to sports, reduction of early posttraumatic osteoarthritis and preservation of the patient's native ACL tissue and proprioceptive envelope of the knee...
April 20, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29619397/treatment-of-failed-articular-cartilage-reconstructive-procedures-of-the-knee-a-systematic-review
#14
REVIEW
Joseph D Lamplot, Kevin A Schafer, Matthew J Matava
Background: Symptomatic articular cartilage lesions of the knee are common and are being treated surgically with increasing frequency. While many studies have reported outcomes following a variety of cartilage restoration procedures, few have investigated outcomes of revision surgery after a failed attempt at cartilage repair or reconstruction. Purpose: To investigate outcomes of revision cartilage restoration procedures for symptomatic articular cartilage lesions of the knee following a previously failed cartilage reconstructive procedure...
March 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29589953/ten-year-results-of-medial-open-wedge-high-tibial-osteotomy-and-chondral-resurfacing-in-severe-medial-osteoarthritis-and-varus-malalignment
#15
Philipp Schuster, Markus Geßlein, Michael Schlumberger, Philipp Mayer, Raul Mayr, Damian Oremek, Sebastian Frank, Martin Schulz-Jahrsdörfer, Jörg Richter
BACKGROUND: High tibial osteotomy (HTO) is a widely used treatment option for medial osteoarthritis and varus malalignment, especially in young patients with early osteoarthritis. Limited outcome data are available for this procedure in severe osteoarthritis, and no long-term data are available using newer implants. PURPOSE: To determine survivorship and functional results of medial open-wedge HTO combined with a chondral resurfacing (CR) procedure (abrasion plus microfracture) in severe medial osteoarthritis (Kellgren-Lawrence grade 3 and 4) and varus malalignment...
March 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29569326/in-vitro-and-in-vivo-performance-of-methacrylated-gellan-gum-hydrogel-formulations-for-cartilage-repair
#16
Carlos A Vilela, Cristina Correia, Alain da Silva Morais, Tírcia C Santos, Ana C Gertrudes, Elsa S Moreira, Ana M Frias, David A Learmonth, Pedro Oliveira, Joaquim M Oliveira, Rui A Sousa, João D Espregueira-Mendes, Rui L Reis
Methacrylated gellan gum (GGMA) formulation is proposed as a second-generation hydrogel for controlled delivery of cartilage-forming cells into focal chondral lesions, allowing immediate in situ retention of cells and 3D filling of lesion volume, such approach deemed compatible with an arthroscopic procedure. Formulation optimization was carried out in vitro using chondrocytes and adipose mesenchymal stromal/stem cells (ASC). A proof-of-concept in vivo study was conducted using a rabbit model with induced chondral lesions...
March 22, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29568558/regulation-of-lubricin-for-functional-cartilage-tissue-regeneration-a-review
#17
REVIEW
Yunsup Lee, Jaehoon Choi, Nathaniel S Hwang
Background: Lubricin is chondrocyte-secreted glycoprotein that primarily conducts boundary lubrication between joint surfaces. Besides its cytoprotective function and extracellular matrix (ECM) attachment, lubricin is recommended as a novel biotherapeutic protein that restore functional articular cartilage. Likewise, malfunction of lubrication in damaged articular cartilage caused by complex and multifaceted matter is a major concern in the field of cartilage tissue engineering. Main body: Although a noticeable progress has been made toward cartilage tissue regeneration through numerous approaches such as autologous chondrocyte implantation, osteochondral grafts, and microfracture technique, the functionality of engineered cartilage is a challenge for complete reconstruction of cartilage...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29565642/matrix-applied-characterized-autologous-cultured-chondrocytes-versus-microfracture-five-year-follow-up-of-a-prospective-randomized-trial
#18
Mats Brittberg, David Recker, John Ilgenfritz, Daniel B F Saris
BACKGROUND: Matrix-based cell therapy improves surgical handling, increases patient comfort, and allows for expanded indications with better reliability within the knee joint. Five-year efficacy and safety of autologous cultured chondrocytes on porcine collagen membrane (MACI) versus microfracture for treating cartilage defects have not yet been reported from any randomized controlled clinical trial. PURPOSE: To examine the clinical efficacy and safety results at 5 years after treatment with MACI and compare these with the efficacy and safety of microfracture treatment for symptomatic cartilage defects of the knee...
March 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29536127/outcomes-of-cartilage-repair-techniques-for-chondral-injury-in-the-hip-a-systematic-review
#19
REVIEW
Naoki Nakano, Chetan Gohal, Andrew Duong, Olufemi R Ayeni, Vikas Khanduja
OBJECTIVE/PURPOSE: The aim of the study was to assess the options of treatment and their related outcomes for chondral injuries in the hip based on the available evidence whilst highlighting new and innovative techniques. METHODS: A systematic review of the literature from PubMed (Medline), EMBASE, Google Scholar, British Nursing Index (BNI), Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Allied and Complementary Medicine Database (AMED) was undertaken from their inception to March 2017 using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
March 13, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29534869/arthroscopic-hip-surgery-with-a-microfracture-procedure-of-acetabular-full-thickness-chondral-damage-cohort-study-with-a-3-year-follow-up
#20
J Más Martínez, J Sanz-Reig, C M Verdú Román, D Bustamante Suárez de Puga, M Morales Santías, E Martínez Giménez
INTRODUCTION AND PURPOSE: Management of injuries to the articular cartilage is complex and challenging. Our purpose was to assess outcomes of a cohort of patients who underwent hip arthroscopy with full-thickness chondral damage treated with microfracture and compare these outcomes with those from a similar cohort of patients who did not. MATERIAL AND METHODS: We prospectively gathered the data of 31 hips treated with microfracture from January 2009 to January 2016...
March 10, 2018: Revista Española de Cirugía Ortopédica y Traumatología
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