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Microfracture

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https://www.readbyqxmd.com/read/28720091/clinical-and-imaging-outcome-of-osteochondral-lesions-of-the-talus-treated-using-autologous-matrix-induced-chondrogenesis-technique-with-a-biomimetic-scaffold
#1
Domenico Albano, Nicolò Martinelli, Alberto Bianchi, Carmelo Messina, Francesco Malerba, Luca Maria Sconfienza
BACKGROUND: The purpose of our study was to assess the clinical and imaging outcome of autologous matrix-induced chondrogenesis (AMIC) technique consisting of microfractures followed by the filling of osteochondral lesions of the talus (OLTs) with a cell-free biphasic collagen-hydroxyapatite osteochondral scaffold (MaioRegen). METHODS: Sixteen patients (eight males, age: 42.6 ± 18.4, range 14-74) with OLT repaired using AMIC technique, with implantation of MaioRegen, were clinically evaluated through the American Orthopedic Foot and Ankle Society Score (AOFAS) and a 10-point Visual Analogue Scale (VAS) pain score after a mean follow-up of 30 ± 16...
July 18, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28713920/low%C3%A2-dose-halofuginone-inhibits-the-synthesis-of-type-i-collagen-without-influencing-type-ii-collagen-in-the-extracellular-matrix-of-chondrocytes
#2
Zeng Li, Hao Fei, Zhen Wang, Tianyi Zhu
Full‑thickness and large area defects of articular cartilage are unable to completely repair themselves and require surgical intervention, including microfracture, autologous or allogeneic osteochondral grafts, and autologous chondrocyte implantation. A large proportion of regenerative cartilage exists as fibrocartilage, which is unable to withstand impacts in the same way as native hyaline cartilage, owing to excess synthesis of type I collagen in the matrix. The present study demonstrated that low‑dose halofuginone (HF), a plant alkaloid isolated from Dichroa febrifuga, may inhibit the synthesis of type I collagen without influencing type II collagen in the extracellular matrix of chondrocytes...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28706807/labral-gracilis-tendon-allograft-reconstruction-and-cartilage-regeneration-scaffold-for-an-uncontained-acetabular-cartilage-defect-of-the-hip
#3
Laurel E MacInnis, Ahmed Al Hussain, Catherine Coady, Ivan H Wong
Hip cartilage injuries are very common, with rates as high as 50% having been reported in some series; abnormal femoral acetabular contact can result in a full-thickness cartilage defect or labral lesion. The prevalence of labral lesions can be as high as 55%. This Technical Note describes an arthroscopic technique to reconstruct an uncontained, full-thickness, focal cartilage defect of the acetabulum, with reconstruction of the missing labrum using a gracilis allograft and use of a biological liquid scaffold for cartilage reconstruction...
June 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28697530/modern-cartilage-imaging-of-the-ankle
#4
Marc André Weber, Felix Wünnemann, Pia M Jungmann, Benita Kuni, Christoph Rehnitz
Background Talar osteochondral lesions are an important risk factor for the development of talar osteoarthritis. Furthermore, osteochondral lesions might explain persistent ankle pain. Early diagnosis of accompanying chondral defects is important to establish the optimal therapy strategy and thereby delaying or preventing the onset of osteoarthritis. The purpose of this review is to explain modern cartilage imaging with emphasis of MR imaging as well as the discussion of more sophisticated imaging studies like CT-arthrography or functional MR imaging...
July 11, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28692374/is-there-a-role-for-stem-cells-in-treating-articular-injury
#5
Yusuf H Mirza, Sam Oussedik
Articular cartilage is a specialized tissue with a high prevalence of injuries. The complex architecture of articular cartilage means that injuries are difficult to treat. The sequelae of such injuries include post-traumatic osteoarthritis. Current treatments include microfracture, microdrilling, osteochondral transplantation and matrix autologous chondral implantation. However, current surgical therapies have a number of disadvantages. Mesenchymal stem cells have been suggested as a potential alternative therapy, with a theoretical ability to regenerate articular cartilage...
July 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/28688892/vascular-ossification-pathology-mechanisms-and-clinical-implications
#6
Michael A Fuery, Lusha Liang, Frederick S Kaplan, Emile R Mohler
In recent years, the mechanisms and clinical significance of vascular calcification have been increasingly investigated. For over a century, however, pathologists have recognized that vascular calcification is a form of heterotopic ossification. In this review, we aim to describe the pathology and molecular processes of vascular ossification, to characterize its clinical significance and treatment options, and to elucidate areas that require further investigation. The molecular mechanisms of vascular ossification involve the activation of regulators including bone morphogenic proteins and chondrogenic transcription factors and the loss of mineralization inhibitors like fetuin-A and pyrophosphate...
July 5, 2017: Bone
https://www.readbyqxmd.com/read/28666028/regeneration-of-hyaline-like-cartilage-in-situ-with-sox9-stimulation-of-bone-marrow-derived-mesenchymal-stem-cells
#7
Xiaowei Zhang, Shili Wu, Ty Naccarato, Manan Prakash-Damani, Yuan Chou, Cong-Qiu Chu, Yong Zhu
Microfracture, a common procedure for treatment of cartilage injury, induces fibrocartilage repair by recruiting bone marrow derived mesenchymal stem cells (MSC) to the site of cartilage injury. However, fibrocartilage is inferior biomechanically to hyaline cartilage. SRY-type high-mobility group box-9 (SOX9) is a master regulator of chondrogenesis by promoting proliferation and differentiation of MSC into chondrocytes. In this study we aimed to test the therapeutic potential of cell penetrating recombinant SOX9 protein in regeneration of hyaline cartilage in situ at the site of cartilage injury...
2017: PloS One
https://www.readbyqxmd.com/read/28662010/-the-impact-of-dynamic-platform-exercises-on-knee-joint-muscle-strength-in-patients-with-gonarthrosis-treated-with-microfracture-method
#8
Kamil Klupiński, Jakub Krochmalski, Marta Woldańska-Okońska
Osteoarthritis is the most common joint disease. Gonarthrosis is one of the most serious diseases the highly developed modern medicine must face. The number of patients suffering from joint pain and progressive disability is growing, especially in economically developed countries. Over the years, the disease has been considered merely as a symptom of aging and the effect of "wear and tear" of the cartilage. At present it is known that the degenerative joint disease is of chronic and progressive nature and its pathogenesis is complex...
June 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28654811/return-to-running-following-knee-osteochondral-repair-using-an-anti-gravity-treadmill-a-case-report
#9
Karen Hambly, Somruthai Poomsalood, Emma Mundy
BACKGROUND: The purpose of this study was to assess the impact of an anti-gravity treadmill return to running programme on self-efficacy and subjective knee function following knee osteochondral surgery. CASE DESCRIPTION: A 39-year-old otherwise healthy female endurance runner with a left knee femoral cartilage grade 3-4 defect 3 cm(2). The patient underwent single step arthroscopic microfracture with Bone Marrow Aspirate Concentrate. An AlterG(®) anti-gravity treadmill was used to manipulate loading during a graduated phased return to running over 8 weeks...
July 2017: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28645131/osteochondral-autologous-transplantation-compared-to-microfracture-for-treating-osteochondral-defect-an-updated-meta-analysis-of-randomized-controlled-trials
#10
Zhao Haien, Wu Jiachang, Li Qiang, Mei Yufeng, Ji Zhenwei
No abstract text is available yet for this article.
June 23, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28639852/osteochondritis-dissecans-etiology-pathology-and-imaging-with-a-special-focus-on-the-knee-joint
#11
Juergen Bruns, Mathias Werner, Christian Habermann
This article is a review of the current understanding of the etiology, pathogenesis, and how to diagnose and treat knee osteochondritis dissecans (OCD) followed by an analysis of and outcomes of the treatments available. OCD is seen in children and adolescents with open growth plates (juvenile OCD) and adults with closed growth plates (adult OCD). The etiology of OCD lesions remains unclear and is characterized by an aseptic necrosis in the subchondral bone area. Mechanical factors seem to play an important role...
June 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28636468/do-ligamentum-teres-tears-portend-inferior-outcomes-in-patients-with-borderline-dysplasia-undergoing-hip-arthroscopic-surgery-a-match-controlled-study-with-a-minimum-2-year-follow-up
#12
Edwin O Chaharbakhshi, Itay Perets, Lyall Ashberg, Brian Mu, Christopher Lenkeit, Benjamin G Domb
BACKGROUND: Arthroscopic surgery in borderline dysplastic hips remains controversial, but the role of the ligamentum teres (LT) has not been studied in this setting. HYPOTHESIS: Borderline dysplastic patients with LT tears have worse short-term outcomes than those without LT tears. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: Data were prospectively collected on patients who underwent arthroscopic surgery between February 2008 and April 2014...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28633799/interposition-ankle-arthroplasty-using-acellular-dermal-matrix-a%C3%A2-small-series
#13
Brian Carpenter, Kyle Duncan, Jordan Ernst, Dalton Ryba, Sumihiro Suzuki
Although ankle arthrodesis is the reference standard for end-stage ankle arthritis, loss of mobility and adjacent joint arthritis are consequences that alternatives to arthrodesis attempt to avoid. The purpose of the present study was to report the clinical results of interpositional arthroplasty using acellular dermal matrix in 4 patients (age 32 to 42 years) for the treatment of advanced ankle osteoarthritis. The primary findings included relief of pain, with improvement in tibiotalar joint range of motion from a mean of 16...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28632588/survivorship-and-outcomes-10-years-following-hip-arthroscopy-for-femoroacetabular-impingement-labral-debridement-compared-with-labral-repair
#14
Travis J Menge, Karen K Briggs, Grant J Dornan, Shannen C McNamara, Marc J Philippon
BACKGROUND: Studies have demonstrated hip arthroscopy to be an effective treatment for femoroacetabular impingement (FAI) with associated labral tears. The purposes of this study were to report 10-year outcomes and hip survival following hip arthroscopy for FAI and to compare labral debridement with labral repair. METHODS: Prospectively collected data on patients followed for a minimum of 10 years after hip arthroscopy for FAI with either labral debridement or labral repair performed by a single surgeon were retrospectively analyzed...
June 21, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28632455/joint-preservation-techniques-in-orthopaedic-surgery
#15
Philip J York, Frank B Wydra, Matthew E Belton, Armando F Vidal
CONTEXT: With increasing life expectancy, there is growing demand for preservation of native articular cartilage to delay joint arthroplasties, especially in younger, active patients. Damage to the hyaline cartilage of a joint has a limited intrinsic capacity to heal. This can lead to accelerated degeneration of the joint and early-onset osteoarthritis. Treatment in the past was limited, however, and surgical treatment options continue to evolve that may allow restoration of the natural biology of the articular cartilage...
June 1, 2017: Sports Health
https://www.readbyqxmd.com/read/28630722/hip-arthroscopy-protocol-expert-opinions-on-post-operative-weight-bearing-and-return-to-sports-guidelines
#16
Ehud Rath, Zachary T Sharfman, Matan Paret, Eyal Amar, Michael Drexler, Nicolas Bonin
The objectives of this study are to survey the weight-bearing limitation practices and delay for returning to running and impact sports of high volume hip arthroscopy orthopedic surgeons. The study was designed in the form of expert survey questionnaire. Evidence-based data are scares regarding hip arthroscopy post-operative weight-bearing protocols. An international cross-sectional anonymous Internet survey of 26 high-volume hip arthroscopy specialized surgeons was conducted to report their weight-bearing limitations and rehabilitation protocols after various arthroscopic hip procedures...
January 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28624855/ct-arthrography-visualizes-tissue-growth-of-osteochondral-defects-of-the-talus-after-microfracture
#17
Hong-Geun Jung, Na-Ra Kim, Ji-Young Jeon, Dong-Oh Lee, Jun-Sang Eom, Jong-Soo Lee, Sung-Wook Kim
PURPOSE: Little is known about the arthroscopic or radiographic outcomes after arthroscopic microfracture of osteochondral lesions of the talus (OLTs). The purpose of this study was to investigate tissue growth after arthroscopic microfracture of OLTs using computed tomography arthrography (CTA) and to identify the relationship between CTA findings and clinical outcomes. We hypothesized that the morphology of the repaired tissue would be similar to that of normal anatomy and correlate with the clinical outcomes...
June 17, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28612705/treatment-of-acetabular-chondral-lesions-with-microfracture-technique
#18
Claudio Mella, Alvaro Nuñez, Ignacio Villalón
INTRODUCTION: Acetabular cartilage lesions are frequently found during hip arthroscopy. In the hip joint they mostly occur secondary to a mechanical overload resulting from a pre-existing deformity as hip dysplasia or femoroacetabular impingement (FAI). Lesions identified during arthroscopy can vary greatly from the earliest stages to the most advanced (full-thickness lesions). These lesions occur in the acetabulum in the early stages of joint damage. Microfractures are indicated in full-thickness chondral defects...
2017: SICOT-J
https://www.readbyqxmd.com/read/28608754/a-preliminary-study-comparing-microfracture-and-local-adherent-transplantation-of-autologous-adipose-derived-stem-cells-followed-by-intraarticular-injection-of-platelet-rich-plasma-for-the-treatment-of-chondral-defects-in-rabbits
#19
Timea Spakova, Judita Amrichova, Jana Plsikova, Denisa Harvanova, Slavomir Hornak, Valent Ledecky, Jan Rosocha
Objective This study aimed to compare microfracture and application of adipose-derived stem cells (ADSCs) by local adherent technique enhanced by platelet-rich plasma (PRP) to provide a new approach for the repair of cartilage defect. Design Full-thickness cylindrical defects were created in the medial femoral condyle in 9 New Zealand White rabbits (5 months old, 4.65 ± 0.20 kg). Two groups of rabbits ( n = 3) were either treated with ADSCs (Group 1) or the microfracture technique (Group 2) following intraarticular injection of PRP 3 times in weekly intervals...
June 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28589877/arthroscopic-treatment-of-chondral-defects-in-the-hip-amic-maci-microfragmented-adipose-tissue-transplantation-matt-and-other-options
#20
Eugenio Jannelli, Andrea Fontana
Chondral lesions are currently considered in the hip as a consequence of trauma, osteonecrosis, dysplasia, labral tears, loose bodies, dislocation, previous slipped capital femoral epiphysis and Femoro-Acetabular-Impingement (FAI). The management of chondral lesions is debated and several techniques are described. The physical examination must be carefully performed, followed by radiographs and magnetic resonance imaging (MRI). Differential diagnosis with other pathologies must be considered. Debridement is indicated in patients younger than 50 years with a chondropathy of 1st or 2nd degree...
2017: SICOT-J
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