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https://www.readbyqxmd.com/read/28542924/effects-of-mechanical-loading-on-human-mesenchymal-stem-cells-for-cartilage-tissue-engineering
#1
Jane Ru Choi, Kar Wey Yong, Jean Yu Choi
Today, articular cartilage damage is a major health problem, affecting people of all ages. The existing conventional articular cartilage repair techniques, such as autologous chondrocyte implantation (ACI), microfracture and mosaicplasty, have many shortcomings which negatively affect their clinical outcomes. Therefore, it is essential to develop an alternative and efficient articular repair technique that can address those shortcomings. Cartilage tissue engineering, which aims to create a tissue-engineered cartilage derived from human mesenchymal stem cells (MSCs), shows great promise for improving articular cartilage defect therapy...
May 19, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28526569/total-joint-replacement-for-neglected-posterior-knee-dislocation-following-septic-arthritis-after-arthroscopy
#2
Yusuf Öztürkmen, Yunus Emre Akman, Ethem Ayhan Ünkar, Erhan Şükür
This report presents the first case of a knee dislocation following septic arthritis after arthroscopy. A 65-year-old woman had an arthroscopy with irrigation and debridement (I&D) of the joint and microfracture for the chondral lesions. She had complaints of postarthroscopic infection but non-steroidal anti-inflammatory medication and local ice compression was recommended. She revisited her physician twice and at the last visit she had a large purulent effusion in her knee. The gram stain of the joint fluid aspirate demonstrated gram-positive cocci and the cultures grew methicilline-sensitive Staphylococcus aureus...
May 16, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28520461/clinical-outcome-after-arthroscopic-debridement-and-microfracture-for-osteochondritis-dissecans-of-the-capitellum
#3
Rens Bexkens, Kim I M van den Ende, Paul T Ogink, Christiaan J A van Bergen, Michel P J van den Bekerom, Denise Eygendaal
BACKGROUND: Various surgical treatment techniques have been developed to treat capitellar osteochondritis dissecans; however, the optimal technique remains the subject of ongoing debate. PURPOSE: To evaluate clinical outcomes after arthroscopic debridement and microfracture for advanced capitellar osteochondritis dissecans. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: Between 2008 and 2015, the authors followed 77 consecutive patients (81 elbows) who underwent arthroscopic debridement and microfracture, and loose body removal if needed, for advanced capitellar osteochondritis dissecans...
May 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28516106/a-cost-effectiveness-analysis-of-surgical-treatment-modalities-for-chondral-lesions-of-the-knee-microfracture-osteochondral-autograft-transplantation-and-autologous-chondrocyte-implantation
#4
REVIEW
John B Schrock, Matthew J Kraeutler, Darby A Houck, Matthew B McQueen, Eric C McCarty
BACKGROUND: Numerous surgical options exist to treat chondral lesions in the knee, including microfracture (MFx), osteochondral autograft transplantation (OAT), first-generation autologous chondrocyte implantation (ACI-1), and next-generation ACI (ACI-2). PURPOSE: To compare the cost-effectiveness of MFx, OAT, and ACI-1. The secondary purpose of this study was to compare the functional outcomes of MFx, OAT, ACI-1, and ACI-2. STUDY DESIGN: Systematic review; Level of evidence, 2...
May 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28476395/all-arthroscopic-treatment-of-dependent-osteochondral-lesions-of-the-ankle-surgical-technique
#5
Nick R Johnson, Spencer Skinner, Amgad M Haleem
A large number of articular cartilage defect treatments have been described. However, few have discussed the use of biologic agents implanted into the so-called dependent defect arthroscopically. Furthermore, even fewer of these reports have contained a description for treating dependent osteochondral lesions of the tibial plafond. Generally, these lesions have been treated with either microfracture or debridement, and the long-term outcomes have been less than satisfactory. With new interest in biologic treatments for osteochondral defects, we believe that bone marrow aspirate concentrate combined with a biologic scaffold provides the necessary components to provide healing of these so-called dependent lesions...
May 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28459642/analysis-of-the-current-indications-for-microfracture-of-chondral-lesions-in-the-hip-joint-response
#6
Darrin J Trask, James S Keene
No abstract text is available yet for this article.
May 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28459639/analysis-of-the-current-indications-for-microfracture-of-chondral-lesions-in-the-hip-joint-letter-to-the-editor
#7
Ruipeng Guo, Bin Xu
No abstract text is available yet for this article.
May 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28459638/analysis-of-the-current-indications-for-microfracture-of-chondral-lesions-in-the-hip-joint-letter-to-the-editor
#8
Halis Atil Atilla, Sivashanmugam Raju
No abstract text is available yet for this article.
May 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28459637/analysis-of-the-current-indications-for-microfracture-of-chondral-lesions-in-the-hip-joint-response
#9
James S Keene
No abstract text is available yet for this article.
May 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28458555/the-effect-of-sodium-hyaluronate-chondroitin-sulfate-combined-solution-on-cartilage-formation-in-osteochondral-defects-of-the-rabbit-knee-an-experimental-study
#10
Haci Bayram Tosun, Murat Gürger, Seyit Ali Gümüştaş, Abuzer Uludag, Özlem Üçer, Sancar Serbest, Suat Çelik
OBJECTIVE: In focal cartilage lesions, multipotent mesenchymal stem cells in bone marrow are aimed to be moved into the defect area using subchondral drilling or microfracture method. However, repaired tissue insufficiently fills the defect area or cannot meet natural hyaline tissue functions, due to fibrous structure. We investigated the effect of a combined solution of sodium hyaluronate + chondroitin sulfate (HA+CS) administered intra-articularly after subchondral drilling on newly formed cartilage in rabbits with focal osteochondral defects...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28448709/-ankle-arthroscopy-in-treatment-of-bosworth-fracture
#11
D Saraiva, R Pereira, A Sarmento, R Lemos, X M Oliva
The Bosworth fracture is a pattern of fracture-dislocation of the ankle joint with fixed dislocation of the proximal part of the fibula behind the posterior malleolus. It is a rare injury, which requires high index of suspicion for diagnosis. Fixed dislocation of the fibula does not allow for closed reduction, so open reduction and fixation of fibula or tibia is required. We present a case report of a patient who suffered a Bosworth fracture, with associated medial malleolus fracture. She underwent surgical treatment with open reduction and internal fixation of the fibula and tibia...
September 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28423287/microfracture-versus-autologous-chondrocyte-implantation-for-articular-cartilage-lesions-in-the-knee-a-systematic-review-of-5-year-outcomes
#12
Matthew J Kraeutler, John W Belk, Justin M Purcell, Eric C McCarty
BACKGROUND: Microfracture (MFx) and autologous chondrocyte implantation (ACI) are 2 surgical treatment options used to treat articular cartilage injuries of the knee joint. PURPOSE: To compare the midterm to long-term clinical outcomes of MFx versus ACI for focal chondral defects of the knee. STUDY DESIGN: Systematic review. METHODS: A systematic review was performed by searching PubMed, the Cochrane Library, and Embase to locate studies (level of evidence I-III) comparing the minimum average 5-year clinical outcomes of patients undergoing MFx versus ACI...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28422531/femoroacetabular-impingement-in-professional-football-players-return-to-play-and-predictors-of-career-length-after-hip-arthroscopy
#13
Travis J Menge, Sanjeev Bhatia, Shannen C McNamara, Karen K Briggs, Marc J Philippon
BACKGROUND: Previous studies have shown hip arthroscopy to be a highly effective treatment for symptomatic femoroacetabular impingement (FAI) in a wide range of athletes; however, the rate of return to play and length of career after hip arthroscopy in professional football players are unknown. PURPOSE: To determine how many athletes returned to professional football and the number of seasons they played after surgery. STUDY DESIGN: Case series; Level of evidence, 4...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28419612/delayed-gadolinium-enhanced-mri-of-cartilage-dgemric-and-t2-mapping-of-talar-osteochondral-lesions-indicators-of-clinical-outcomes
#14
Christoph Rehnitz, Benita Kuni, Felix Wuennemann, Dimitrios Chloridis, Anand Kirwadi, Iris Burkholder, Hans-Ulrich Kauczor, Marc-André Weber
PURPOSE: To evaluate the utility of delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) and T2 mapping in evaluation of type II osteochondral lesions (OCLs) of the talus and define cutoff values for identifying patients with good/poor clinical outcomes. MATERIALS AND METHODS: 28 patients (mean age, 42.3 years) underwent T2 mapping and dGEMRIC at least 1.5 years (mean duration, 3.5 years) after microfracture (n = 12) or conservative (n = 16) treatment for type II OCL...
April 17, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28409105/anatomic-single-bundle-anterior-cruciate-ligament-reconstruction-using-the-modified-transtibial-technique
#15
Dhong Won Lee, Jin Goo Kim
We present a technique for anterior cruciate ligament (ACL) reconstruction using hamstring tendon autograft with a modified transtibial technique. Our modified transtibial technique has the advantages of the conventional transtibial technique that is familiar to surgeons and that allows the press-fit fixing and enables us to make a relatively long femoral tunnel. To make the femoral tunnel at the anatomic position, the triangular, funnel-shaped bony trough was made to slip the eccentrically positioned guide pin into the anticipated anatomic center with a free-hand technique after marking the anatomic ACL footprint using a microfracture awl through the anteromedial portal...
February 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28409096/ankle-arthroscopy-with-microfracture-for-osteochondral-defects-of-the-talus
#16
Suman Medda, Ian M Al'Khafaji, Aaron T Scott
Therapeutic arthroscopy with microfracture leads to fibrocartilaginous repair and is an effective treatment of osteochondral lesions of the talus. A full diagnostic arthroscopy is performed, and then attention is turned to the osteochondral defect. We describe in detail patient positioning, ankle distraction, portal placement, steps of the diagnostic arthroscopy, and the technique of microfracture. We then discuss the special considerations to be taken regarding the use of a distractor, protection of neurovascular structures, and the indications for microfracture...
February 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28406876/cartilage-restoration-techniques-for-the-patellofemoral-joint
#17
Robert H Brophy, Robert D Wojahn, Joseph D Lamplot
Symptomatic osteochondral lesions of the patellofemoral joint are clinically challenging to manage because of the limited healing potential of articular cartilage; the complex morphology of the patellofemoral joint; the heterogeneity of the articular surface between patients; and high stresses across the joint, which can be altered by malalignment, tilt, or maltracking. Indications for surgery include traumatic lesions, osteochondritis dissecans, and high-grade chondromalacia in association with persistent pain despite a course of nonsurgical management...
May 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28399641/optimization-of-degradation-profile-for-new-scaffold-in-cartilage-repair
#18
Sarav S Shah, Haixiang Liang, Sandeep Pandit, Zalak Parikh, John A Schwartz, Todd Goldstein, Lawrence P Lavelle, Arindam Datta, Daniel A Grande
Objective To establish whether a novel biomaterial scaffold with tunable degradation profile will aid in cartilage repair of chondral defects versus microfracture alone in vitro and in a rat model in vivo. Design In vitro-Short- and long-term degradation scaffolds were seeded with culture expanded articular chondrocytes or bone marrow mesenchymal stem cells. Cell growth and differentiation were evaluated with cell morphological studies and gene expression studies. In vivo-A microfracture rat model was used in this study to evaluate the repair of cartilage and subchondral bone with the contralateral knee serving as the empty control...
April 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28397530/comparison-of-fixation-techniques-of-3d-woven-poly-%C3%AF%C2%B5-caprolactone-scaffolds-for-cartilage-repair-in-a-weightbearing-porcine-large-animal-model
#19
James M Friedman, Mackenzie L Sennett, Marcelo B Bonadio, Kerry O Orji, Alexander L Neuwirth, Niobra Keah, James L Carey, Franklin T Moutos, Bradley T Estes, Farshid Guilak, Henning Madry, Robert L Mauck, George R Dodge
Objective To test different fixation methods of a 3-dimensionally woven poly(ϵ-caprolactone) (PCL) scaffold within chondral defects of a weightbearing large animal model. Methods Full thickness chondral defects were made in the femoral condyles of 15 adult male Yucatan mini-pigs. Two surgical approaches were compared including total arthrotomy (traditional) and a retinaculum-sparing, minimally invasive surgery (MIS) approach. Following microfracture (MFX), scaffolds were placed without fixation or were fixed with fibrin glue, suture, or subchondral anchor...
April 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28395947/efficacy-of-bone-marrow-stimulating-technique-in-rotator-cuff-repair
#20
Kerem Bilsel, Fatih Yildiz, Mehmet Kapicioglu, Gokcer Uzer, Mehmet Elmadag, Anil Pulatkan, Mukaddes Esrefoglu, Ergun Bozdag, Giuseppe Milano
BACKGROUND: This study used a chronic rotator cuff (RC) tear model to investigate the effect of microfracture as a bone marrow-stimulating (BMS) technique for RC healing. METHODS: A chronic retracted RC tendon tear model was created bilaterally in the subscapularis tendons of 20 New Zealand rabbits. The tendons were repaired after 8 weeks using a single-row configuration. Tendons in the right shoulder were repaired in standard fashion (control group). Microfractures were performed in the left shoulders before repair (microfracture group)...
April 7, 2017: Journal of Shoulder and Elbow Surgery
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