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Goblet Cell Tumor

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https://www.readbyqxmd.com/read/28713616/baicalein-wogonin-and-scutellaria-baicalensis-ethanol-extract-alleviate-ovalbumin-induced-allergic-airway-inflammation-and-mast-cell-mediated-anaphylactic-shock-by-regulation-of-th1-th2-imbalance-and-histamine-release
#1
Thi Tho Bui, Chun Hua Piao, Chang Ho Song, Chang-Hyun Lee, Hee Soon Shin, Ok Hee Chai
Asthma is characterized by chronic inflammation, goblet cell hyperplasia, the aberrant production of the Th2 cytokines, and eosinophil infiltration into the lungs. In this study, we examined the effects of baicalein, wogonin, and Scutellaria baicalensis ethanol extract on ovalbumin (OVA)-induced asthma by evaluating Th1/Th2 cytokine levels, histopathologic analysis, and compound 48/80-induced systemic anaphylaxis and mast cell activation, focusing on the histamine release from rat peritoneal mast cells. Baicalein, wogonin, and S...
June 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/28659644/are-goblet-cell-carcinoids-a-group-of-heterogeneous-tumors
#2
Jirka Macak, Kristina Nemejcova, Jana Dvorackova
BACKGROUND: Goblet cell carcinoids belong to neuroendocrine tumors, according to the WHO classification. The tumors are diagnosed based on a typical histological pattern and using neuroendocrine markers. However, some tumors do not react with these markers and yet expression of proliferative markers is high. Do these tumors belong to G1 and G2 neuroendocrine tumors? METHODS: The sample comprised nine cases of tumors of the appendix identified by immunohistological methods as goblet cell carcinoids or adenocarcinoma ex goblet cell carcinoid...
June 12, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/28646079/identification-of-flavin-containing-monooxygenase-5-fmo5-as-a-regulator-of-glucose-homeostasis-and-a-potential-sensor-of-gut-bacteria
#3
Flora Scott, Sandra G Gonzalez Malagon, Brett A O'Brien, Diede Fennema, Sunil Veeravalli, Clarissa R Coveney, Ian R Phillips, Elizabeth A Shephard
We have previously identified flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing. The aim of the present study was to investigate the role of FMO5 in glucose homeostasis and the impact of diet and gut flora on the phenotype of mice in which the Fmo5 gene has been disrupted (Fmo5(-/-) mice). In comparison with wild-type (WT) counterparts, Fmo5(-/-) mice are resistant to age-related changes in glucose homeostasis and maintain the higher glucose tolerance and insulin sensitivity characteristic of young animals...
June 23, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28637362/spindle-cell-mucoepidermoid-carcinoma-of-the-palatine-tonsil-with-crtc1-maml2-fusion-transcript-report-of-a-rare-case-in-a-17-year-old-boy-and-a-review-of-the-literature
#4
Giap Hean Goh, Chwee Ming Lim, Tomas Vanacek, Michal Michal, Fredrik Petersson
Mucoepidermoid carcinoma (MEC) with a predominant spindle cell composition occurring in the palatine tonsil is exceedingly rare. We present a case of a 17-year-old boy with an uncommon spindle cell variant of MEC arising in the palatine tonsil. Histologically, the tumor showed a solid, noncystic architecture and was composed of a predominant population of bland spindle to fusiform cells arranged in organoid nests with interspersed goblet cells and focal areas of ductular structures. Reverse transcriptase polymerase chain reaction and fluorescence in situ hybridization (FISH) revealed the presence of a t(11;19) CRTC1-MAML2 gene fusion in this rare variant of MEC...
June 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28602741/disease-resistance-and-response-against-vibrio-anguillarum-intestinal-infection-in-european-seabass-dicentrarchus-labrax-fed-low-fish-meal-and-fish-oil-diets
#5
S Torrecillas, M J Caballero, D Mompel, D Montero, M J Zamorano, L Robaina, F Rivero-Ramírez, V Karalazos, S Kaushik, M Izquierdo
The aim of this study was to assess the effects of low levels of dietary fish meal (FM) and fish oil (FO) on disease resistance and gut associated lymphoid tissue (GALT) response after an experimental intestinal infection with V. anguillarum in European sea bass (Dicentrarchus labrax) For that purpose, sea bass juveniles were fed one of four diets containing combined levels of FO and FM as follows: 20%FM/6%FO, 20%FM/3%FO, 5%FM/6%FO and 5%FM/3%FO during 153 days. At the end of the feeding trial, fish were subjected to either an in vivo exposure to a sub-lethal dose of V...
August 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28598706/citrus-tachibana-leaves-ethanol-extract-alleviates-airway-inflammation-by-the-modulation-of-th1-th2-imbalance-via-inhibiting-nf-%C3%AE%C2%BAb-signaling-and-histamine-secretion-in-a-mouse-model-of-allergic-asthma
#6
Thi Tho Bui, Chun Hua Piao, Soo Mi Kim, Chang Ho Song, Hee Soon Shin, Chang-Hyun Lee, Ok Hee Chai
Asthma is a chronic inflammatory disease of bronchial airway, which is characterized by chronic airway inflammation, airway edema, goblet cell hyperplasia, the aberrant production of the Th2 cytokines, and eosinophil infiltration in the lungs. In this study, the therapeutic effect and the underlying mechanism of Citrus tachibana leaves ethanol extract (CTLE) in the ovalbumin (OVA)-induced allergic asthma and compound 48/80-induced anaphylaxis were investigated. Oral administration of CTLE inhibited OVA-induced asthmatic response by reducing airway inflammation, OVA-specific IgE and IgG1 levels, and increasing OVA-specific IgG2a levels...
July 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28587293/pathological-analysis-of-ocular-lesions-in-a-murine-model-of-sj%C3%A3-gren-s-syndrome
#7
Aya Ushio, Rieko Arakaki, Hiroshi Eguchi, Fumika Hotta, Akiko Yamada, Yasusei Kudo, Naozumi Ishimaru
Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by severe inflammation of exocrine glands such as the salivary and lacrimal glands. When it affects the lacrimal glands, many patients experience keratoconjunctivitis due to severely dry eyes. This study investigated the pathological and immunological characteristics of ocular lesions in a mouse model of SS. Corneal epithelial injury and hyperplasia were confirmed pathologically. The number of conjunctival mucin-producing goblet cells was significantly decreased in the SS model mice compared with control mice...
June 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28577958/lepidic-predominant-adenocarcinoma-and-invasive-mucinous-adenocarcinoma-of-the-lung-exhibit-specific-mucin-expression-in-relation-with-oncogenic-drivers
#8
Duruisseaux Michaël, Antoine Martine, Rabbe Nathalie, Rodenas Anita, Mc Leer-Florin Anne, Lacave Roger, Poulot Virginie, Duchêne Belinda, Van Seuningen Isabelle, Cadranel Jacques, Wislez Marie
OBJECTIVES: To evaluate MUC1, MUC2, MUC5B, MUC5AC, and MUC6 expression in invasive lepidic predominant adenocarcinoma (LPA) and invasive mucinous adenocarcinoma (IMA) of the lung, and the impact of oncogenic drivers. MATERIALS AND METHODS: MUC1, MUC2, MUC5B, MUC5AC, MUC6, TTF1 and Hnf4α immunohistochemistry was performed on surgical samples from 52 patients with IMA (n=25) or LPA (n=27). We searched for EGFR, KRAS, BRAF, and HER2 mutations and ALK, ROS1, and NRG1 rearrangements...
July 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28556957/increased-frequency-of-bronchiolar-histotypes-in-lung-carcinomas-associated-with-idiopathic-pulmonary-fibrosis
#9
Anna Caliò, Veronica Lever, Andrea Rossi, Eliana Gilioli, Matteo Brunelli, Alessandra Dubini, Sara Tomassetti, Sara Piciucchi, Alessia Nottegar, Giulio Rossi, Marianne Kambouchner, Alessandra Cancellieri, Mattia Barbareschi, Giuseppe Pelosi, Claudio Doglioni, Alberto Cavazza, Rodolfo Carella, Paolo Graziano, Bruno Murer, Venerino Poletti, Marco Chilosi
AIMS: The association between lung cancer and idiopathic pulmonary fibrosis (IPF) is well-known, however the significance of this association is poorly understood. Bronchiolar honeycomb cysts have been proposed as possible precursors for development of carcinoma, but limited evidence of this hypothesis is available. METHODS AND RESULTS: Thirty-three lung carcinomas arising in patients with IPF have been analyzed using a panel of immunohistochemical markers. The antibodies included pneumocyte markers (TTF1, Napsin-A, SPA1), the goblet cell marker MUC5AC, markers of basal/squamous cell differentiation (CK5/6, ΔN-p63) and markers related to enteric differentiation (CDX2, MUC2, CK20, villin)...
May 30, 2017: Histopathology
https://www.readbyqxmd.com/read/28554219/differential-diagnosis-of-a-rare-papillary-tumor-and-mucinous-adenocarcinoma
#10
Shunichiro Matsuoka, Ryoichi Kondo, Keiko Ishii
Ciliated muconodular papillary tumors are characterized as rare papillary tumors of the peripheral lung, and involve ciliated, goblet, and basal cell proliferation with mucin secretion. We report the case of a 76-year-old woman who had an irregular solid nodule in the lung on chest computed tomography during a health screening. A wedge resection was performed. Although the intraoperative cytological diagnosis was mucinous adenocarcinoma, the final histological diagnosis was ciliated muconodular papillary tumor...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28551326/appendiceal-goblet-cell-carcinoid-common-errors-in-staging-and-clinical-interpretation-with-a-proposal-for-an-improved-terminology
#11
Kwun Wah Wen, Gillian Hale, Nafis Shafizadeh, Mojgan Hosseini, Anne Huang, Sanjay Kakar
Goblet cell carcinoid (GCC) is staged and treated as adenocarcinoma (AC) and not as neuroendocrine tumor (NET) or neuroendocrine carcinoma. The term 'carcinoid' may lead to incorrect interpretation as NET. To explore pitfalls in staging and clinical interpretation of GCC and mixed GCC-AC, and propose strategies to avoid common errors. Diagnostic terminology, staging and clinical interpretation were evaluated in 58 cases (27 GCC, 31 mixed GCC-AC). Opinions were collected from 23 pathologists using a survey. Clinical notes were reviewed to assess the interpretation of pathology diagnoses by oncologists...
May 24, 2017: Human Pathology
https://www.readbyqxmd.com/read/28513991/immunoprotective-effect-of-chitosan-particles-on-hymenolepis-nana-infected-mice
#12
Mahmoud Abdel-Latif, Gamal El-Shahawi, Shawky M Aboelhadid, Heba Abdel-Tawab
Hymenolepis nana is the most commonly known intestinal cestode infecting mainly human. The present study aimed to investigate the potential effect of chitosan particles (CSP) to enhance the immune system against H. nana infection. Determination of worm burden, egg output, histopathological changes, oxidative stress markers (lipid peroxidation & reduced glutathione), goblet (GCs) and mucosal mast cells (MMCs) counts in intestinal ileum were performed. In addition, levels of intestinal mRNA expression of interleukin (IL)-4, IL-9, stem cell factor (SCF), type I & II interferons (IFN)-α/ γ, tumor necrosis factor (TNF)-α, mucin 2 (MUC2), and inducible nitric oxide synthase (iNOs) were investigated using real-time PCR...
May 17, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28488624/papillary-craniopharyngioma-a-clinicopathologic-study-of-a-rare-entity-from-a-major-tertiary-care-center-in-pakistan
#13
Muhammad Usman Tariq, Nasir Ud Din, Zubair Ahmad, Wasim Memon
BACKGROUND: Papillary craniopharyngioma (PCP) are uncommon variants of craniopharyngiomas (CP), which are benign epithelial neoplasms of the sellar and suprasellar region. Histologically, PCPs are typically composed of well-differentiated stratified squamous epithelium; however, focal variations are not uncommon. A distinction from other lesions of the region, despite being difficult to achieve due to the overlapping radiological and clinical features, is important for adequate treatment to be administered...
May 2017: Neurology India
https://www.readbyqxmd.com/read/28465325/epithelial-src-homology-region-2-domain-containing-phosphatase-1-restrains-intestinal-growth-secretory-cell-differentiation-and-tumorigenesis
#14
Caroline Leblanc, Marie-Josée Langlois, Geneviève Coulombe, Vanessa Vaillancourt-Lavigueur, Christine Jones, Julie C Carrier, François Boudreau, Nathalie Rivard
Shp-1 (Src homology region 2 domain-containing protein tyrosine phosphatase-1) is a phosphatase that is highly expressed in hematopoietic and epithelial cells. Whereas its function is largely characterized in hematopoietic cells, its role in epithelial cells, such as intestinal epithelial cells (IECs), is not well known. Here, we generated mice with an IEC-specific deletion of Shp-1 (Src homology region 2 domain-containing phosphatase-1; Shp-1(IEC-KO)). We showed that the loss of epithelial Shp-1 leads to an intestinalomegaly that is associated with an increase in epithelial cell proliferation and size...
May 2, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28463910/diffusely-metastasized-adenocarcinoma-arising-in-a-mucinous-carcinoid-of-the-ovary-a-case-report
#15
Anne-Sophie Van Rompuy, Adriaan Vanderstichele, Ignace Vergote, Philippe Moerman
Mucinous (goblet cell) carcinoids are a rare type of ovarian carcinoid tumors. Only a limited number of primary mucinous carcinoids of the ovary have been reported in the literature. We describe the case of a 55-year-old woman with a diffusely metastasized adenocarcinoma arising in a primary ovarian mucinous carcinoid. The differential diagnosis with a metastatic goblet cell carcinoid from the appendix or elsewhere can be very challenging. In our case, especially the immunohistochemical profile of the tumor with diffuse positivity for cytokeratin 7 and PAX8, and no expression of cytokeratin 20 and CDX2, directed us toward a primary ovarian origin...
April 29, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28449607/adenocarcinoma-ex-goblet-cell-carcinoid-of-the-appendix-with-metastatic-peritoneal-spread-to-meckel-s-diverticulum-and-endometriosis
#16
Brett Matthew Lowenthal, Grace Y Lin, Ann M Ponsford Tipps, Mojgan Hosseini
Adenocarcinoma ex-goblet cell carcinoid is a very rare and histologically unique appendiceal malignancy with dual glandular and neuroendocrine differentiation. There is a high incidence of this tumor among middle-aged women with metastasis to the gynecologic tract with the mode of metastasis following peritoneal spread rather than hematogenous distribution. Adenocarcinoma ex-goblet cell carcinoid can spread to any peritoneal site including ovaries or omentum. We report a 37-year-old healthy woman who initially presented with right lower quadrant abdominal pain and pseudomyxoma peritonei...
April 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28429507/mucinous-hidradenoma-in-a-child-a-case-report-and-review-of-the-literature
#17
Aadil Ahmed, Wendy Kim, Jodi Speiser
Hidradenomas are benign tumors of the sweat glands that are rarely reported in childhood. The presence of mucinous change in hidradenomas, which consists of variable numbers of mucin-rich goblet cells, is occasionally observed in some adult clinical practices. However, it has not been previously reported in the pediatric population. Herein, we present a unique case of a mucinous hidradenoma presenting on the thigh of a 3-year old boy. The clinical presentation and histological features of the case, along with a literature review of published case reports of pediatric hidradenomas are described...
April 21, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28411376/nodular-oncocytic-hyperplasia-can-cytomorphology-allow-for-the-preoperative-diagnosis-of-a-nonneoplastic-salivary-disease
#18
Lisa M Rooper, Mine Onenerk, Momin T Siddiqui, William C Faquin, Justin A Bishop, Syed Z Ali
BACKGROUND: Nodular oncocytic hyperplasia (oncocytosis) of the salivary glands is a benign process that does not inherently require surgical excision. However, cytologic findings in fine-needle aspiration (FNA) of oncocytosis cases have not been well characterized previously, limiting preoperative identification. METHODS: All available cases of oncocytosis with corresponding FNA specimens were identified from the pathology archives of 3 academic institutions. Clinical, cytologic, and histologic findings were tabulated for all cases...
April 14, 2017: Cancer
https://www.readbyqxmd.com/read/28393194/metallothionein-1g-promotes-the-differentiation-of-ht-29-human-colorectal-cancer-cells
#19
Juan Martín Arriaga, Alicia Inés Bravo, José Mordoh, Michele Bianchini
Metallothioneins (MTs) are a family of low-molecular-weight, cysteine-rich proteins involved in zinc and redox metabolism, that are epigenetically downregulated during colorectal cancer (CRC) progression, but may be re-induced with a variety of agents. Since loss of MT expression is associated with a worse prognosis, in the present study we investigated the effects of overexpression of the most significantly downregulated isoform in CRC, namely MT1G, on the HT-29 cell line. Overexpression of MT1G resulted in xenograft tumors with an aberrant morphology, characterized by an evident increase in mucin-containing cells that were identified as goblet cells under electron microscopy...
May 2017: Oncology Reports
https://www.readbyqxmd.com/read/28363996/mir-34a-and-mir-34b-c-suppress-intestinal-tumorigenesis
#20
Longchang Jiang, Heiko Hermeking
The p53-inducible miR-34a and miR-34b/c genes are frequently silenced in colorectal cancer. To address the in vivo relevance of miR-34a/b/c function for suppression of intestinal tumor formation, we generated Apc(Min/+) mice with deletions of the miR-34a and/or miR-34b/c genes separately or in combination. Combined deletion of miR-34a/b/c increased the number of intestinal stem cells as well as Paneth and Goblet cells, resulting in enlarged intestinal crypts. miR-34a/b/c-deficient Apc(Min/+) mice displayed an increased tumor burden and grade and decreased survival...
May 15, 2017: Cancer Research
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