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Goblet Cell Tumor

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https://www.readbyqxmd.com/read/29662312/nanoselenium-prevents-eimeriosis-induced-inflammation-and-regulates-mucin-gene-expression-in-mice-jejunum
#1
Abdulsalam A Alkhudhayri, Mohamed A Dkhil, Saleh Al-Quraishy
Background: Although elemental selenium has been found to be effective against Eimeria , no study has yet investigated the effects of selenium nanoparticles (SeNPs) on the Eimeria parasite. The aim of this study, therefore, was to evaluate the ameliorative effect of SeNPs compared with elemental selenium on mice jejunum infected with sporulated oocysts of Eimeria papillata . Methods: The mice were divided into 4 groups, with the first being the non-infected, control group, and the second, third, and fourth groups being orally inoculated with 1,000 sporulated oocysts of E...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29624892/antibiotic-mediated-bacteriome-depletion-in-apc-min-mice-is-associated-with-reduction-in-mucus-producing-goblet-cells-and-increased-colorectal-cancer-progression
#2
Kamaljeet Kaur, Arpit Saxena, Irina Debnath, Jacqueline L O'Brien, Nadim J Ajami, Thomas A Auchtung, Joseph F Petrosino, Alexander-Jacques Sougiannis, Sarah Depaep, Alexander Chumanevich, Phani M Gummadidala, Mayomi H Omebeyinje, Sourav Banerjee, Ioulia Chatzistamou, Paramita Chakraborty, Raja Fayad, Franklin G Berger, James A Carson, Anindya Chanda
Recent epidemiological evidence suggests that exposure to antibiotics in early-to-middle adulthood is associated with an increased risk of colorectal adenoma. However, mechanistic studies in established preclinical cancer to examine these claims are extremely limited. Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis...
April 6, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29607953/a-rare-case-of-ampullary-goblet-cell-carcinoid
#3
Hitoshi Shibuya, Susumu Hijioka, Nobumasa Mizuno, Takamichi Kuwahara, Nozomi Okuno, Tsutomu Tanaka, Makoto Ishihara, Yutaka Hirayama, Sachiyo Oonishi, Yoshiko Murakami, Yasushi Yatabe, Masahiro Tajika, Yasumasa Niwa, Kazuo Hara
An asymptomatic 70-year-old woman was referred to our hospital because of liver enzyme elevation. Enhanced abdominal computed tomography demonstrated a small, round-shaped tumor with dilation of the common bile duct (CBD) and main pancreatic duct (MPD). A biopsy specimen from the papilla showed mucin-containing cells that were positive for endocrine markers on immunohistochemical staining. Endoscopic snare resection was done, and there was a positive vertical margin on pathology. Pancreaticoduodenectomy was then performed later...
March 30, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29579011/histologic-and-outcome-study-supports-reclassifying-appendiceal-goblet-cell-carcinoids-as-goblet-cell-adenocarcinomas-and-grading-and-staging-similarly-to-colonic-adenocarcinomas
#4
Masato Yozu, Melanie E Johncilla, Amitabh Srivastava, David P Ryan, James C Cusack, Leona Doyle, Namrata Setia, Michelle Yang, Gregory Y Lauwers, Robert D Odze, Joseph Misdraji
Goblet cell carcinoid tumors are amphicrine tumors whose biological behavior ranges from indolent to highly aggressive, depending on tumor grade. Current grading systems for these tumors are based on identifying an adenocarcinoma arising in the setting of a goblet cell carcinoid tumor, which distinguishes this tumor from other gastrointestinal tract adenocarcinomas. Because goblet cell tumors are predominantly tumors of mucin secreting cells, we propose that they be classified as goblet cell adenocarcinomas, and graded using a methodology that has parallels in colorectal adenocarcinoma grading...
March 23, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29564121/effects-of-dietary-bacillus-amyloliquefaciens-supplementation-on-growth-performance-intestinal-morphology-inflammatory-response-and-microbiota-of-intra-uterine-growth-retarded-weanling-piglets
#5
Yue Li, Hao Zhang, Weipeng Su, Zhixiong Ying, Yueping Chen, Lili Zhang, Zhaoxin Lu, Tian Wang
Background: The focus of recent research has been directed toward the probiotic potential of Bacillus amyloliquefaciens (BA) on the gut health of animals. However, little is known about BA's effects on piglets with intra-uterine growth retardation (IUGR). Therefore, this study investigated the effects of BA supplementation on the growth performance, intestinal morphology, inflammatory response, and microbiota of IUGR piglets. Methods: Eighteen litters of newborn piglets were selected at birth, with one normal birth weight (NBW) and two IUGR piglets in each litter (i...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29529279/nonclinical-safety-assessment-of-the-%C3%AE-secretase-inhibitor-avagacestat
#6
Frank J Simutis, Thomas P Sanderson, Gary D Pilcher, Michael J Graziano
The toxicity of avagacestat, a sulfonamide-based gamma (γ)-secretase inhibitor that was in development as a treatment for Alzheimer's disease, was evaluated in a comprehensive nonclinical toxicology program that included 6-month and 1-year repeat-dose toxicity studies in rats and dogs, respectively. There was a spectrum of mechanism-based changes attributed to inhibition of Notch signaling that regulates the differentiation and proliferation of cells throughout development and in adult tissues. In both rats and dogs, ovarian follicular degeneration and atrophy and a low incidence of granulosa cell hyperplasia and benign granulosa-thecal cell tumors were observed...
February 24, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29479957/neuroendocrine-tumors-detected-in-appendectomy-specimens-ten-year-single-center-experience
#7
Fatma Şenel, Hatice Karaman, Hacer Demir
Background/aim: The aim of this study was to investigate neuroendocrine tumors (NETs) detected in appendectomy specimens and the incidence and clinicopathologic characteristics of these tumors in our center. Materials and methods: A total of 13,863 patients were evaluated retrospectively. All underwent appendectomy operation in the Kayseri Training and Research Hospital and had a histopathological examination at the Pathology Clinic between January 2007 and March 2017. Age, sex, preoperative clinical findings, operation procedure, and histopathological examination results of the cases reported to be NET are presented...
February 23, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29422640/mutational-landscape-of-goblet-cell-carcinoids-and-adenocarcinoma-ex-goblet-cell-carcinoids-of-the-appendix-is-distinct-from-typical-carcinoids-and-colorectal-adenocarcinomas
#8
Melanie Johncilla, Matthew Stachler, Joseph Misdraji, Mikhail Lisovsky, Masato Yozu, Neal Lindeman, Gregory Y Lauwers, Robert D Odze, Amitabh Srivastava
There is limited data on the spectrum of molecular alterations in goblet cell carcinoids and adenocarcinoma ex goblet cell carcinoids of the appendix. We used next generation sequencing to determine mutations of potential pathogenetic and therapeutic significance in this rare group of tumors. Adequate DNA was successfully extracted in 34/46 cases and the final group included 18 goblet cell carcinoids and 16 adenocarcinoma ex goblet cell carcinoids. Illumina TruSeq™ was used for sequencing exons of a custom 282 gene panel using an Illumina HiSeq 2000...
February 8, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29415898/thyroid-sclerosing-mucoepidermoid-carcinoma-with-eosinophilia-distinct-from-the-salivary-type
#9
Mitsuyoshi Hirokawa, Nami Takada, Hideyuki Abe, Ayana Suzuki, Miyoko Higuchi, Akihiro Miya, Toshitetsu Hayashi, Mitsuhiro Fukushima, Akihiko Kawahara, Akira Miyauchi
We report three cases of thyroid sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE), which is an extremely rare variant of mucoepidermoid carcinoma (MEC). The aims of this report were to describe the clinicopathological findings, including results from immunohistochemical and fluorescence in situ hybridization analysis of thyroid SMECE, as well as to discuss the distinction between thyroid SMECE and its salivary counterpart. The cases included a 63-year-old female, a 44-year-old male, and a 66-year-old female, with all patients presenting with Hashimoto's thyroiditis...
February 8, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29414399/goblet-cell-carcinoid-of-the-appendix-an-interobserver-variability-study-using-two-proposed-classification-systems
#10
Chelsea Maedler, Thomas Arnason, Alastair Dorreen, Heidi Sapp, Mathieu Castonguay, Joanne Murphy, Sorin Selegean, Weei-Yuarn Huang
Goblet cell carcinoid (GCC) is an uncommon tumor of the vermiform appendix. Due to a broad spectrum of morphological differentiation, subclassification and grading of GCCs remains an area of controversy. Two separate systems have proposed classifying GCC tumors into three (classical GCC; adenocarcinoma ex-GCC, signet ring cell type; adenocarcinoma ex-GCC, poorly differentiated carcinoma type) OR two subgroups (low and high grade GCC) based on morphological criteria. We independently compared the inter-observer variability associated with each classification system...
February 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29399338/expression-of-doublecortin-and-cam-kinase-like-1-protein-in-serrated-neoplasia-of-the-colorectum
#11
Keiko Morio, Kazuo Yashima, Akihiro Tamoto, Kohei Hosoda, Sohei Yamamoto, Taku Iwamoto, Naoki Ueda, Yuichiro Ikebuchi, Koichiro Kawaguchi, Kenichi Harada, Yoshikazu Murawaki, Hajime Isomoto
The adenoma-carcinoma sequence (ACS) and the serrated pathway are two distinct developmental routes leading to the formation of colorectal carcinoma. Recently, the doublecortin and CaM kinase-like-1 protein (DCLK1) has been reported to serve as an intestinal cancer stem cell marker and has been demonstrated to be overexpressed through the ACS; however, there is a lack of reports on the role of DCLK1 in the serrated pathway. To clarify the correlation between DCLK1 protein expression and clinicopathological characteristics of the serrated tumorigenic pathway, the present study used immunohistochemistry to examine the expression of DCLK1 in endoscopically resected samples of 62 serrated polyps [20 hyperplastic polyps (HPs), 16 traditional serrated adenomas (TSAs) and 26 sessile serrated adenoma-polyps (SSA/Ps)], as well as 20 non-serrated adenomas, 20 carcinoma in adenomas (CIAs) and 18 early pure colorectal carcinomas without any adenoma component (EPCs)...
January 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29327707/appendiceal-goblet-cell-carcinoids-and-adenocarcinomas-ex-goblet-cell-carcinoid-are-genetically-distinct-from-primary-colorectal-type-adenocarcinoma-of-the-appendix
#12
Moritz Jesinghaus, Björn Konukiewitz, Sebastian Foersch, Albrecht Stenzinger, Katja Steiger, Alexander Muckenhuber, Claudia Groß, Martin Mollenhauer, Wilfried Roth, Sönke Detlefsen, Wilko Weichert, Günter Klöppel, Nicole Pfarr, Anna Melissa Schlitter
The appendix gives rise to goblet cell carcinoids, which represent special carcinomas with distinct biological and histological features. Their genetic background and molecular relationship to colorectal adenocarcinoma is largely unknown. We therefore performed a next-generation sequencing analysis of 25 appendiceal carcinomas including 11 goblet cell carcinoids, 7 adenocarcinomas ex-goblet cell carcinoid, and 7 primary colorectal-type adenocarcinomas, using a modified Colorectal Cancer specific Panel comprising 32 genes linked to colorectal and neuroendocrine tumorigenesis...
January 12, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29288693/mixed-adenoneuroendocrine-carcinoma-a-review-of-pathologic-characteristics
#13
Shayna A Brathwaite, Stephen M Smith, Lai Wai, Wendy Frankel, John Hays, Martha M Yearsley, Sherif Abdel-Misih
Mixed adenoneuroendocrine carcinoma (MANEC) is a rare pathologic entity defined as a tumor exhibiting both adenocarcinoma and neuroendocrine carcinoma components. Though uncommon, these tumors show aggressive behavior and generally portend a poor prognosis. This study seeks to further define clinicopathological characteristics of MANEC to aid in accurate diagnosis and properly direct clinical management. Thirty-four confirmed MANECs were identified in our 25-year retrospective review of cases arising in the gastrointestinal tract...
March 2018: Human Pathology
https://www.readbyqxmd.com/read/29286080/a-murine-model-of-dry-eye-induced-by-topical-administration-of-erlotinib-eye-drops
#14
Qi-Chen Yang, Jing Bao, Cheng Li, Gang Tan, An-Hua Wu, Lei Ye, Lin-Hong Ye, Qiong Zhou, Yi Shao
In the present study, the effects of erlotinib on mouse tear function and corneal epithelial tissue structure were investigated. Throughout the 3 weeks of treatment, no notable differences were observed in the body, eye or lacrimal gland weights of the control and experimental mice. However, in the experimental group, the tear volume and break‑up times of tear film were significantly lower following treatment with erlotinib compared with the control group. Corneal fluorescein staining in the experimental group revealed patchy staining, and the Lissamine green staining and inflammatory index were significantly higher in the experimental group at 3 weeks than in the control group...
March 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29285080/orally-administered-sodium-4-phenylbutyrate-suppresses-the-development-of-dextran-sulfate-sodium-induced-colitis-in-mice
#15
Kazuhiko Ono, Satoshi Nimura, Yuko Hideshima, Kazuki Nabeshima, Manabu Nakashima
Sodium 4-phenylbutyrate (PBA) exerts therapeutic effects in a wide range of pathologies. A previous study by the present authors revealed that intraperitoneal administration of PBA suppresses the onset of dextran sulfate sodium (DSS)-induced colitis in mice. In the present study, the effects of orally administered PBA are investigated, as this route of administration is more clinically relevant. The therapeutic efficacy of PBA (10 mg/12 h) in mice with experimental colitis was assessed based on the disease activity index, production of inflammatory cytokines, colon length and histopathological investigations...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29228651/dietary-feeding-of-freeze-dried-whole-cranberry-inhibits-intestinal-tumor-development-in-apc-min-mice
#16
Duochen Jin, Tianyu Liu, Wenxiao Dong, Yujie Zhang, Sinan Wang, Runxiang Xie, Bangmao Wang, Hailong Cao
It is increasingly perceived that dietary components have been linked with the prevention of intestinal cancer. Cranberry is a rich source of phenolic constituents and non-digestible fermentable dietary fiber, which shows anti-proliferation effect in colorectal cancer cells. Herein, we investigated the efficacy of long-term cranberry diet on intestinal adenoma formation in Apc min/+ mice. Apc min/+ mice were fed a basal diet or a diet containing 20% (w/w) freeze-dried whole cranberry powder for 12 weeks, and the number and size of tumors were recorded after sacrifice...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29151835/-opuntia-humifusa-modulates-morphological-changes-characteristic-of-asthma-via-il-4-and-il-13-in-an-asthma-murine-model
#17
Soon-Young Lee, Chun-Sik Bae, Young-Hoon Choi, Nam-Sook Seo, Chang-Su Na, Jin-Cheol Yoo, Seung Sik Cho, Dae-Hun Park
Asthma is a chronic pulmonary disease that affects an estimated 235 million people worldwide, but asthma drugs have many adverse effects. Opuntia humifusa (eastern prickly pear) has been used as a food and traditional medicine worldwide; however, its anti-asthmatic effects have not been reported. We evaluated O. humifusa as a potential therapeutic or preventive component of anti-asthmatic drugs. We divided ovalbumin-sensitized mice into the following groups: normal control, asthma-induced control, dexamethasone-treated group (positive control), 50 mg/kg O...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29116460/potential-usefulness-of-methyl-gallate-in-the-treatment-of-experimental-colitis
#18
María Laura Anzoise, Angeles Rodríguez Basso, Julieta Sofía Del Mauro, Andrea Carranza, Graciela López Ordieres, Susana Gorzalczany
Methyl gallate is a gallotannin widely distributed in nature. Previous studies have demonstrated its antioxidant, anti-inflammatory, antimicrobial and anti-tumor activities. In the present study, the activity of methyl gallate on experimental models of inflammatory bowel disease has been investigated. Experimental colitis was induced in Sprague-Dawley rats through the intracolonic instillation of an acetic acid solution (2 mL, 4% v/v). Methyl gallate (100 and 300 mg/kg, p.o.) and the reference drug mesalazine (100 mg/kg, p...
November 7, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29071443/assessment-of-the-effectiveness-of-cyclosporine-nasal-spray-in-an-animal-model-of-allergic-rhinitis
#19
Erol Senturk, Yavuz Selim Yildirim, Remzi Dogan, Orhan Ozturan, Eray Metin Guler, Mehmet Serif Aydin, Abdurrahim Kocyigit, Mukaddes Esrefoglu, Ilker Kocak
The aim of this study is to show if cyclosporine has an antiallergic role in a rat model of ovalbumin-induced allergic rhinitis. The 54 rats were divided into six equal groups. The first group was a negative control group without induced allergic rhinitis; the second group a positive control with induced allergic rhinitis not receiving treatment. The remaining four groups, after induction of allergic rhinitis, received intranasal cyclosporine treatment in doses of 0.05, 0.1, or 0.2% or nasal steroid treatment...
January 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29045292/ovarian-metastases-of-breast-cancers-with-signet-ring-cells-a-report-of-17-cases-including-14-krukenberg-tumors
#20
Jennifer A Bennett, Robert H Young, Ai-Ying Chuang, Melinda F Lerwill
Krukenberg tumor, defined as metastatic adenocarcinoma to the ovary containing at least 10% signet ring cells, usually arises from the stomach but can also originate from other sites. We reviewed 17 metastatic breast carcinomas to the ovary with signet ring cells to potentially identify features indicative of mammary origin as opposed to other possible primary sites. The patients ranged from 41 to 76 (mean, 53.6) yr. Fourteen had a prior history of invasive breast carcinoma (invasive ductal carcinoma, 4; invasive lobular carcinoma, 3; adenocarcinoma not otherwise specified, 3; carcinoma with ductal and lobular features, 2; and unspecified carcinoma, 2) and metastases were identified 2 to 284 (mean, 79) mo after the original diagnosis...
October 17, 2017: International Journal of Gynecological Pathology
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