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signet ring carcinoma

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https://www.readbyqxmd.com/read/28821194/primary-benign-and-malignant-thyroid-neoplasms-with-signet-ring-cells-cytologic-histologic-and-molecular-features
#1
Nada A Farhat, Ayse M Onenerk, Jeffrey F Krane, Dora Dias-Santagata, Peter M Sadow, William C Faquin
Objectives: Signet ring cells (SRCs) can be seen in a variety of thyroid tumors and can pose a diagnostic pitfall on cytology. This study describes the cytologic, histomorphologic, and molecular aspects of a cohort of primary thyroid tumors with SRCs. Methods: A search was performed of the Massachusetts General Hospital and Brigham and Women's Hospital (Boston, MA) pathology archives for the keywords thyroid, signet, and signet ring features between 2000 and 2014...
September 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28819369/in-vitro-cytotoxic-activities-of-the-oral-platinum-iv-prodrug-oxoplatin-and-hsp90-inhibitor-ganetespib-against-a-panel-of-gastric-cancer-cell-lines
#2
Lukas Klameth, Barbara Rath, Gerhard Hamilton
Gastric cancer exhibits a poor prognosis and is the third most common cause of cancer death worldwide. Chemotherapy of metastatic gastric cancer is based on combinations of platinum drugs and fluoropyrimidines, with added agents. Oxoplatin is a stable oral platinum(IV) prodrug which is converted to a highly active tetrachlorido(IV) complex under acidic conditions. In the present work, we studied the cytotoxic effects of oxoplatin against a panel of four gastric cancer cell lines in vitro. Furthermore, the role of HSP90 in chemoresistance of these lines was investigated using the specific inhibitor ganetespib...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28816940/signet-ring-cell-carcinoma-of-early-gastric-cancer-is-endoscopic-treatment-really-risky
#3
Sun Hyung Kang, Joo Seok Kim, Hee Seok Moon, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong
Signet ring cell carcinoma (SRC) is a poorly differentiated cancer of the stomach. Generally, poorly differentiated cancer is believed to show poor prognosis and aggressive behavior. Recently, however, there is debate on the aggressiveness of SRC in early gastric cancer (EGC). We therefore studied postoperation biopsies to investigate the aggressiveness of SRC in EGC.We reviewed medical records of patients with EGC who had surgery from January 2011 to December 2015 in a tertiary hospital in Daejeon, South Korea...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28816144/comparison-of-treatment-outcome-between-invasive-lobular-and-ductal-carcinomas-in-patients-receiving-partial-breast-irradiation-with-intraoperative-electrons
#4
COMPARATIVE STUDY
Maria Cristina Leonardi, Patrick Maisonneuve, Mauro Giuseppe Mastropasqua, Federica Cattani, Giuseppe Fanetti, Anna Morra, Roberta Lazzari, Federica Bazzani, Mariangela Caputo, Nicole Rotmensz, Marianna Alessandra Gerardi, Rosalinda Ricotti, Viviana Enrica Galimberti, Paolo Veronesi, Samantha Dicuonzo, Giuseppe Viale, Barbara Alicja Jereczek-Fossa, Roberto Orecchia
PURPOSE: To investigate the local outcome of patients after accelerated partial breast irradiation with intraoperative electrons (IORT) for invasive lobular carcinoma (ILC) compared with invasive ductal carcinoma (IDC). METHODS AND MATERIALS: From 1999 to 2007, 2173 patients were treated with breast-conserving surgery and IORT (21 Gy/1 fraction) as the sole local treatment: 252 patients with ILC (11.6%) were compared with 1921 patients with IDC in terms of local control...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28789931/clinical-analysis-of-primary-colorectal-signet-ring-cell-carcinoma
#5
REVIEW
ZhengZi Liang, DengGuo Yan, GuoSheng Li, HaiYu Cheng
The objective of the study was to investigate the clinicopathological features of primary colorectal signet-ring cell carcinoma. We retrospectively analyzed the clinical and survival data of 37 patients with primary colorectal signet-ring cell carcinoma. The mean survival time of patients in stage II, III, and IV were estimated using Student t test and the cumulative survival rates were estimated according to the method of Kaplan-Meier. The significance of the differences in survival rates were calculated using the log rank test...
July 8, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28781796/gastric-adenocarcinoma-at-the-anastomotic-site-50-years-after-gastrojejunostomy-a-case-report
#6
Tsutomu Namikawa, Yasuhiro Kawanishi, Kazune Fujisawa, Eri Munekage, Masaya Munekage, Hiromichi Maeda, Hiroyuki Kitagawa, Michiya Kobayashi, Kazuhiro Hanazaki
We herein report a rare case of superficially spreading early gastric cancer occurring 50 years after gastrojejunostomy. An 83-year-old woman was diagnosed with gastric cancer after complaining of epigastric discomfort. The patient had undergone gastrojejunostomy with Braun jejunojejunostomy for benign chronic peptic ulcer 50 years prior. Esophagogastroduodenoscopy revealed an irregular nodular lesion on the gastric side of the anastomosis of the gastrojejunostomy. No abnormal lesions were identified by abdominal contrast-enhanced computed tomography...
August 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28781789/metastatic-gastric-carcinoma-to-the-breast-a-case-report-and-review-of-the-chinese-literature
#7
Huanhuan Yan, Jun Liu, Xu Ming, Xiaoqian Zhou, Hui Jin, Xiang Li, Miao Zheng
Breast metastasis is extremely unusual in gastric cancer patients worldwide. We herein report the case of a 39-year-old female Chinese patient presenting with symptoms of inflammation in the left breast. A biopsy did not reveal any evidence of malignancy. A modified radical mastectomy was performed and the postoperative pathological examination revealed infiltration by signet ring cell gastric carcinoma. A review of the Chinese literature was performed, and a total of 16 patients with breast metastasis from gastric carcinoma have been reported from 1990 onwards...
August 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28774167/geographic-distribution-of-the-incidence-of-colorectal-cancer-in-iran-a-population-based-study
#8
Fatemeh Khosravi Shadmani, Erfan Ayubi, Salman Khazaei, Mohadeseh Sani, Shiva Mansouri Hanis, Somayeh Khazaei, Mokhtar Soheylizad, Kamyar Mansori
OBJECTIVES: Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer death in the world. The aim of this study was to investigate the provincial distribution of the incidence of CRC across Iran. METHODS: This epidemiologic study used data from the National Cancer Registry of Iran and the Center for Disease Control and Prevention of the Ministry of Health and Medical Education of Iran. The average annual age-standardized rate (ASR) for the incidence of CRC was calculated for each province...
2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28749000/-bone-metastases-of-a-gallbladder-carcinoma-detected-by-positron-emission-tomography-computed-tomography-case-report
#9
Pamela Humeres, Patricio González, Javiera González, Elizabeth Prado, Enrique Hiplan
Signet ring gallbladder carcinoma is a rare aggressive variant of mucinous adenocarcinoma with poor prognosis. Positron emission tomography/computed tomography (PET/CT) with Fluor18 deoxyglucose (F18-FDG) is a useful tool in the staging of gallbladder cancer. We report a 68 years old man with a surgically resected acute cholecystitis, whose biopsy was positive for signet ring cell gallbladder carcinoma. During surgery, locoregional lymph nodes, liver or peritoneal involvement were not detected. A PET/CT was performed for staging, finding multiple hypermetabolic lytic bone lesions...
April 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28746362/survival-predictors-associated-with-signet-ring-cell-carcinoma-of-the-esophagus-srcce-a-population-based-retrospective-cohort-study
#10
Zihao Wan, Zhihao Huang, Liaobin Chen
PURPOSE: Signet ring cell carcinoma of the esophagus (SRCCE) is an uncommon tumor associated with significant morbidity and mortality. There is still no consensus regarding cut-off values for tumor size, age and optimal treatment for SRCCE. Thus, we elucidated the current survival outcomes of patients with SRCCE and analyzed factors associated with prognosis. METHODS: A retrospective cohort study based on the SEER (The Surveillance, Epidemiology, and End Results) program database was conducted...
2017: PloS One
https://www.readbyqxmd.com/read/28743132/therapeutic-outcomes-of-endoscopic-resection-of-early-gastric-cancer-with-undifferentiated-type-histology-a-korean-esd-registry-database-analysis
#11
Chang Seok Bang, Jae Myung Park, Gwang Ho Baik, Jong Jae Park, Moon Kyung Joo, Jae Young Jang, Seong Woo Jeon, Suck Chei Choi, Jae Kyu Sung, Kwang Bum Cho
Background/Aims: To assess the therapeutic outcomes of endoscopic resection (ER) of early gastric cancer (EGC) with undifferentiated-type histology. Methods: Cases of ER of EGC with undifferentiated-type histology in the Korean endoscopic submucosal dissection (ESD) registry database were identified and reviewed. The immediate outcomes, including en bloc resection, complete resection, and curative resection rates, and long-term outcomes, including recurrence and survival rates, were extracted and analyzed...
July 25, 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28735257/prognostic-factors-of-overall-survival-and-cancer-specific-survival-in-patients-with-resected-early-stage-rectal-adenocarcinoma-a-seer-based-study
#12
Ko-Chao Lee, Kuan-Chih Chung, Hong-Hwa Chen, Chia-Cheng Liu, Chien-Chang Lu
The benefits of radiotherapy for colorectal cancer are well documented, but the impact of adjuvant radiotherapy on early-stage rectal adenocarcinoma remains unclear. This study aimed to identify predictors of overall survival (OS) and cancer-specific survival (CSS) in patients with stage II rectal adenocarcinoma treated with preoperative or postoperative radiation therapy. Patients with early-stage rectal adenocarcinoma in the postoperative state were identified using the Surveillance, Epidemiology, and End Results database...
July 21, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28732003/-diffuse-type-of-gastric-cancer-adenocarcinoma-in-10-years-old-boy-report-of-a-case
#13
Nery Romero, Ingrid Zegarra, Hugo Delgado
We report a rare case of diffuse type of gastric cancer with signet ring cells in 10 years old boy who was admitted with a 12 months history with weight loss, dysphagia to solids first and to liquids later, anorexia, fatigue, dizziness, vomiting and later, with pain in the left upper quadrant. On examination, he appeared pale, malnourished, with café-au- lait spots over the trunk and extremities. Laboratory tests showed; Hb 7.5 g, albumin 2.62 g, Thevenon positive on stools. Abdominal ultrasound examination showed periaortic masses and diffuse space occupying lesions in the liver...
April 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28730347/-gastric-signet-ring-cell-carcinoma-new-aspects-for-long-range-prognosis
#14
W Schröder, C Bruns
No abstract text is available yet for this article.
August 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28722095/-correlation-of-mri-apparent-diffusion-coeffcient-with-molecular-marker-ki-67-in-gastric-cancer
#15
Guodian Zheng, Xiangdong Cheng, Lijing Wang, Zhiyuan Xu, Xuning Gao, Pengfei Yu, Hang Lyu, Ting Huang, Jiahui Chen
OBJECTIVES: To study the correlation between MRI apparent diffusion coefficient (ADC) and expression of Ki-67 in gastric cancers, and to investigate the application of ADC value in diagnosing the malignance of gastric cancer. METHODS: A retrospective cohort analysis was performed on 87 gastric cancer patients who received MRI examination and radical resection at Zhejiang Provincial Hospital of Traditional Chinese Medicine from November 2014 to August 2015. All the postoperative resected samples were confirmed as gastric cancer...
July 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28711649/intramucosal-colorectal-carcinoma-with-invasion-of-the-lamina-propria-a-study-by-the-japanese-society-for-cancer-of-the-colon-and-rectum
#16
Motohiro Kojima, Hideyuki Shimazaki, Keiichi Iwaya, Takahiro Nakamura, Hiroshi Kawachi, Kazuhito Ichikawa, Shigeki Sekine, Shingo Ishiguro, Tadakazu Shimoda, Ryoji Kushima, Takashi Yao, Takahiro Fujimori, Kazuo Hase, Toshiaki Watanabe, Kenichi Sugihara, Gregory Y Lauwers, Atsushi Ochiai
Cancer invasion of the lamina propria is an important pathological finding. However, the clinicopathologic features and diagnostic accuracy of intramucosal carcinoma assessment in colorectal carcinoma (CRC) are unknown. In this study, intramucosal CRCs were reviewed in institutions affiliated with the Japanese Society for Cancer of the Colon and Rectum, and 32 cases with invasion of the lamina propria were identified. Next, a consensus meeting was held to select cases with a high consensus about the presence of invasion, which were reviewed by one Western pathologist for confirmation...
July 12, 2017: Human Pathology
https://www.readbyqxmd.com/read/28708232/primary-signet-ring-cell-carcinoma-of-the-pancreas-with-a-good-response-to-chemotherapy-case-report-and-literature-review
#17
Milan Radojkovic, Dragana Ilic, Ivan Ilic
PURPOSE: Although pancreatic cancer is a common malignancy, signet ring cell carcinoma of the pancreas is a very rare histologic type with only 6 cases reported so far. We present a patient with primary signet ring cell carcinoma of the pancreas and a good response to neoadjuvant chemotherapy. CASE REPORT: A 67-year-old woman presented at a regional hospital with a 2-week history of painless progressive jaundice. Abdominal computed tomography showed a tumor in the head of the pancreas, 4...
July 5, 2017: Tumori
https://www.readbyqxmd.com/read/28691258/differences-between-gastric-signet-ring-cell-carcinoma-and-poorly-differentiated-adenocarcinoma-a-comparison-of-histopathologic-features-determined-by-mucin-core-protein-and-trefoil-factor-family-peptide-immunohistochemistry
#18
Ai Fujimoto, Yukio Ishikawa, Toshiharu Ishii, Akihiro Yamada, Yoshinori Igarashi, Yasukazu Ohmoto, Mitsuru Kaise
We investigated differences between the pathological features of gastric signet-ring cell carcinoma (sig) and poorly differentiated adenocarcinoma (por) by examining the expressions of the trefoil factor family peptides (TFFs) and mucin core proteins (MUCs). Ninety-seven tissues of 97 gastric cancer patients were selected for this study. After gastrectomy, the major histopathologic types were determined to be sig, solid-type poorly differentiated adenocarcinoma (por1), non-solid type poorly differentiated adenocarcinoma (por2), and well-differentiated tubular adenocarcinoma (tub1)...
July 9, 2017: Pathology International
https://www.readbyqxmd.com/read/28688938/a-comparative-study-of-endoscopic-surveillance-in-hereditary-diffuse-gastric-cancer-according-to-cdh1-mutation-status
#19
Emma Z Mi, Ella Z Mi, Massimiliano di Pietro, Maria O'Donovan, Richard H Hardwick, Susan Richardson, Hisham Ziauddeen, Paul C Fletcher, Carlos Caldas, Marc Tischkowitz, Krish Ragunath, Rebecca C Fitzgerald
BACKGROUND AND AIMS: Hereditary diffuse gastric cancer (HDGC) accounts for 1% of gastric cancer cases. For patients with a germline CDH1 mutation, risk-reducing gastrectomy is recommended. However, for those delaying surgery or families with no causative mutation identified, regular endoscopy is advised. This study aimed to determine the yield of signet ring cell carcinoma (SRCC) foci in individuals with a CDH1 pathogenic variant compared with those without and how this varies with successive endoscopies...
July 5, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28684029/primary-signet-ring-cell-carcinoma-of-the-colon-a-rare-condition-with-a-poor-prognosis-a-report-on-two-cases
#20
I Mora-Guzmán, M Di Martino, J L Muñoz de Nova, F E Viamontes Ugalde, A Rodríguez Sánchez
No abstract text is available yet for this article.
July 3, 2017: Revista de Gastroenterología de México
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