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https://www.readbyqxmd.com/read/28937897/the-role-of-genetic-factors-in-the-outbreak-mechanism-of-dental-caries
#1
Junko Shimomura-Kuroki, Tomoko Nashida, Yukio Miyagawa, Tsuneo Sekimoto
OBJECTIVE: The aim of the present study was to investigate the relationships between cariogenic bacterial infection and single nucleotide polymorphisms (SNPs) in candidate genes associated with dental caries, and to explore the factors related to caries in children. STUDY DESIGN: Children aged 3 to 11 years were selected. Detection of cariogenic bacteria (Streptococcus mutans, Streptococcus oralis, Streptococcus sobrinus and Lactobacillus) from the plaque of each patient, and SNP analyses of five candidate genes (MBL2, TAS2R38, GLUT2, MMP13 and CA6) were performed using DNA isolated from buccal mucosal cells...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28920793/multi-drug-resistance-patterns-of-enteric-bacteria-in-two-populations-of-free-ranging-eastern-box-turtles-terrapene-carolina-carolina
#2
Cari Rasmussen, Matthew C Allender, Christopher A Phillips, John Byrd, Terrell Lloyd, Carol Maddox
Gram-negative isolates (n = 84) from 71% of free-ranging Eastern box turtles (Terrapene carolina carolina) in Illinois and Tennessee, United States, demonstrated resistance to at least one antibiotic while 30% of isolates demonstrated resistance to two or more antibiotics. Resistance was observed against cefoxitin, amoxicillin-clavulanic acid, cefazolin, ampicillin, ticarcillin, cefovecin, and ceftiofur. Gram-positive bacteria were isolated from 49 turtles, and all were observed to be resistant to two or more antibiotics...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28910633/host-genetic-control-of-the-oral-microbiome-in-health-and-disease
#3
Andres Gomez, Josh L Espinoza, Derek M Harkins, Pamela Leong, Richard Saffery, Michelle Bockmann, Manolito Torralba, Claire Kuelbs, Rohith Kodukula, Jason Inman, Toby Hughes, Jeffrey M Craig, Sarah K Highlander, Marcus B Jones, Chris L Dupont, Karen E Nelson
Host-associated microbial communities are influenced by both host genetics and environmental factors. However, factors controlling the human oral microbiome and their impact on disease remain to be investigated. To determine the combined and relative effects of host genotype and environment on oral microbiome composition and caries phenotypes, we profiled the supragingival plaque microbiome of 485 dizygotic and monozygotic twins aged 5-11. Oral microbiome similarity always increased with shared host genotype, regardless of caries state...
September 13, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28892899/first-detection-and-characterization-of-streptococcus-dentapri-from-caries-active-subject
#4
Hamzah Abdulrahman Salman, R Senthil Kumar, N Chaitanya Babu, Khalid Imran
INTRODUCTION: Mutans streptococci (MS) are a group of oral bacteria generally regarded as the principal agents in the pathogenesis of dental caries. AIM: The study aimed was characterize S. dentapri based on phylogenetic analysis and phenotypic methods from Caries Active Subject. MATERIALS AND METHODS: While sequencing MS species which were isolated from 65 caries active subjects, one strain of S. dentapri was detected. Dental plaque samples were processed and cultured on mitis salivarius bacitracin agar...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28892888/role-of-herbal-agents-tea-tree-oil-and-aloe-vera-as-cavity-disinfectant-adjuncts-in-minimally-invasive-dentistry-an-in-vivo-comparative-study
#5
Gaurav Patri, Aliva Sahu
INTRODUCTION: The prevention and control of caries necessitates the elimination of cariogenic bacteria and cavity disinfectants have proved to play a major role in achieving the goal. The use of phytotherapy is trending and many natural products have shown anti-microbial properties which can be used as cavity disinfectant in the field of dentistry. AIM: The aim of this study was to compare the efficacy of herbal antibacterial agents (Tea Tree Oil (TTO) and Aloe vera) with commercially available 2% chlorhexidine (CHX) as cavity disinfectant for use in minimally invasive dentistry...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28890615/antibacterial-inhibitory-effects-of-punica-granatum-gel-on-cariogenic-bacteria-an-in-vitro-study
#6
Grazielle Millo, Apa Juntavee, Ariya Ratanathongkam, Natsajee Nualkaew, Jomjai Peerapattana, Supaporn Chatchiwiwattana
AIM: This study evaluated the in vitro antibacterial effects of the formulated Punica granatum (PG) gel against Streptococcus mutans, Streptococcus sanguinis, and Lactobacillus casei. MATERIALS AND METHODS: The PG extract was dissolved in water at 500 mg/mL. High performance liquid chromatography (HPLC) was used for identification and quantification of chemical marker punicalagin. Minimum bactericidal concentration (MBC) and time-kill assay (TKA) were investigated...
April 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28890211/antibacterial-photodynamic-therapy-with-curcumin-and-curcuma-xanthorrhiza-extract-against-streptococcus-mutans
#7
Hyung-Jung Lee, Si-Mook Kang, Seung-Hwa Jeong, Ki-Ho Chung, Baek-Il Kim
BACKGROUND: Bacteria are becoming increasingly resistant to conventional antibacterial chemotherapy, which has prompted the application of antibacterial photodynamic therapy (aPDT) in bacteria-related diseases due to its excellent biocide effects. However, few studies have attempted to develop a novel photosensitizer based on natural components. The aim of the present study was to compare the aPDT effects of curcumin and Curcuma xanthorrhiza extract (CXE) against Streptococcus mutans...
September 7, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28861520/arginine-exposure-decreases-acidogenesis-in-long-term-oral-biofilm-microcosms
#8
Ruth G Ledder, Hitesh Mistry, Prem K Sreenivasan, Gavin Humphreys, Andrew J McBain
Arginine is an important pH-elevating agent in the oral cavity. It has been incorporated in oral hygiene formulations to mitigate sensitivity and to prevent caries. In this investigation, the effects of sustained arginine dosing of dental plaque microcosms on bacteriological composition and pH were evaluated under controlled conditions. Plaque microcosms were established in constant-depth film fermentors (CDFFs) using salivary inocula and fed continuously with artificial saliva. To simulate resting and cariogenic states, the CDFFs were supplemented with sterile water or 5% sucrose, respectively...
July 2017: MSphere
https://www.readbyqxmd.com/read/28858630/quantitative-assessment-of-salivary-oral-bacteria-according-to-the-severity-of-dental-caries-in-childhood
#9
Natália H Colombo, Paula F Kreling, Laís F F Ribas, Jesse A Pereira, Christine A Kressirer, Marlise I Klein, Anne C R Tanner, Cristiane Duque
This study aimed to assess differences in selected oral bacteria in children according to the severity of dental caries. One hundred and thirty-six children, 36-60 months old were divided into three groups according to caries status: caries-free (CF) (n=47), early childhood caries (ECC) (n=40) and severe-early childhood caries (S-ECC) (n=49). Saliva was collected for detection and quantification of selected oral streptococci, Actinomyces naeslundii, Lactobacillus spp., Bifidobacterium spp., and Scardovia wiggsiae by quantitative-polymerase chain reaction...
August 16, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28851857/effect-of-probiotic-lactobacilli-on-the-growth-of-streptococcus-mutans-and-multispecies-biofilms-isolated-from-children-with-active-caries
#10
Xiaolong Lin, Xi Chen, Yan Tu, Sa Wang, Hui Chen
BACKGROUND The purpose of this investigation was to evaluate the effect of probiotic lactobacilli on Streptococcus mutans (MS) and multispecies biofilms isolated from children with severe caries. MATERIAL AND METHODS Twenty children with active caries (DMFS ≥6) were selected as the experimental group and Streptococcus mutans (MS) were isolated from their saliva. After identification the MS strains were mixed with lactobacilli at 37°C, following which viable MS colonies were counted. At the same time dental plaques from the children were mixed with lactobacilli in vitro to form biofilms, and the population of nine common strains in the biofilms was enumerated after 24 hours of growth...
August 30, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28816199/early-childhood-caries-a-review
#11
Abdulfatah Alazmah
AIM: To review and update the current knowledge about early childhood caries (ECC) and its etiology, prevalence, risk factors, management, and preventive strategies. BACKGROUND: Early childhood caries is a disease affecting significantly both well-developed and industrial nations. The ECC can significantly affect the child's quality of life, as it may lead to infection, swelling, pain, and other symptoms. The ECC affects children after eruption of primary teeth until age of around 5 years...
August 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28810984/impact-of-a-7-day-field-training-on-oral-health-condition-in-japan-ground-self-defense-force-personnel
#12
Koji Yamashita, Takeshi Nishiyama, Emi Nagata, Atik Ramadhani, Miki Kawada-Matsuo, Hitoshi Komatsuzawa, Takahiko Oho
INTRODUCTION: In the Japan Ground Self-Defense Force (JGSDF), personnel periodically perform intensive training that mimics the conditions seen in battle and during natural disasters. Military training involves intensive, stressful conditions, and changes in immune responses have been found in personnel following training. Good oral condition is important for military personnel to fulfill their duties; however, they have difficulty performing daily oral care under training conditions...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28808691/fluoride-depletes-acidogenic-taxa-in-oral-but-not-gut-microbial-communities-in-mice
#13
Koji Yasuda, Tiffany Hsu, Carey A Gallini, Lauren J Mclver, Emma Schwager, Andy Shi, Casey R DuLong, Randall N Schwager, Galeb S Abu-Ali, Eric A Franzosa, Wendy S Garrett, Curtis Huttenhower, Xochitl C Morgan
Fluoridation of drinking water and dental products prevents dental caries primarily by inhibiting energy harvest in oral cariogenic bacteria (such as Streptococcus mutans and Streptococcus sanguinis), thus leading to their depletion. However, the extent to which oral and gut microbial communities are affected by host fluoride exposure has been underexplored. In this study, we modeled human fluoride exposures to municipal water and dental products by treating mice with low or high levels of fluoride over a 12-week period...
July 2017: MSystems
https://www.readbyqxmd.com/read/28775964/obesity-and-obesity-related-diseases-sugar-consumption-and-bad-oral-health-a-fatal-epidemic-mixtures-the-pediatric-and-odontologist-point-of-view
#14
Anna Pia Delli Bovi, Laura Di Michele, Giuliana Laino, Pietro Vajro
Obesity and dental caries are increasingly widespread pathologies. The former is growing so rapidly that the WHO classified its trend as an "epidemic". Both are triggered by a number of well known common etiologic factors sharing also the high added sugar amount since childhood. Because of its fermentation and pH lowering, dietary sugar allows the cariogenic bacteria to damage the tooth enamel provoking the carious lesions. WHO guidelines recommend reducing sugar intake to 10% of the total daily energy need, and highlight that there is evidence which suggests cuttingthis value down to 5% at least...
January 2017: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/28775282/ecological-effect-of-arginine-on-oral-microbiota
#15
Xin Zheng, Jinzhi He, Lin Wang, Shuangshuang Zhou, Xian Peng, Shi Huang, Liwei Zheng, Lei Cheng, Yuqing Hao, Jiyao Li, Jian Xu, Xin Xu, Xuedong Zhou
Dental caries is closely associated with the microbial dybiosis between acidogenic/aciduric pathogens and alkali-generating commensal bacteria colonized in the oral cavity. Our recent studies have shown that arginine may represent a promising anti-caries agent by modulating microbial composition in an in vitro consortium. However, the effect of arginine on the oral microbiota has yet to be comprehensively delineated in either clinical cohort or in vitro biofilm models that better represent the microbial diversity of oral cavity...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28764202/antimicrobial-effect-of-leaves-of-phyllanthus-niruri-and-solanum-nigrum-on-caries-causing-bacteria-an-in-vitro-study
#16
J Sunitha, Swathy Krishna, R Ananthalakshmi, J Sathiya Jeeva, As Smiline Girija, Nadeem Jeddy
INTRODUCTION: Solanum nigrum and Phyllanthus niruri are common herbs which are indigeneous to India. Solanum nigrum commonly called 'manathakkali Keerai' in Tamil, forms an indispensable part of South Indian diet. Phyllanthus niruri (keezhanelli in Tamil) is a widely used medicinal plant, the leaves of which have been used extensively in Ayurveda and native medicine to cure various liver ailments. The herbs Solanumnigrum and Phyllanthus niruri have been found to be effective against numerous enteropathogens in various in vitro studies...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28759297/self-assembling-anticaries-mucosal-vaccine-containing-ferritin-cage-nanostructure-and-glucan-binding-region-of-s-mutans-glucosyltransferase-effectively-prevents-caries-formation-in-rodents
#17
Xi-Xi Cao, Yu-Hong Li, Qian-Lin Ye, Tian-Feng Wang, Ming-Wen Fan
Anticaries protein vaccines that induce a mucosal immune response are not effective. Therefore, development of effective and convenient anticaries vaccines is a priority of dental research. Here we generated self-assembling nanoparticles by linking the glucan-binding region of Streptococcus mutans glucosyltransferase (GLU) to the N-terminal domain of ferritin to determine whether these novel nanoparticles enhanced the immunogenicity of an anticaries protein vaccine against GLU in rodents. We constructed the expression plasmid pET28a-GLU-FTH and purified the proteins from bacteria using size-exclusion chromatography...
July 31, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28759120/pit-and-fissure-sealants-for-preventing-dental-decay-in-permanent-teeth
#18
REVIEW
Anneli Ahovuo-Saloranta, Helena Forss, Tanya Walsh, Anne Nordblad, Marjukka Mäkelä, Helen V Worthington
BACKGROUND: Dental sealants were introduced in the 1960s to help prevent dental caries, mainly in the pits and fissures of occlusal tooth surfaces. Sealants act to prevent bacteria growth that can lead to dental decay. Evidence suggests that fissure sealants are effective in preventing caries in children and adolescents compared to no sealants. Effectiveness may, however, be related to caries incidence level of the population. This is an update of a review published in 2004, 2008 and 2013...
July 31, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28755761/do-quaternary-ammonium-monomers-induce-drug-resistance-in-cariogenic-endodontic-and-periodontal-bacterial-species
#19
Suping Wang, Haohao Wang, Biao Ren, Hao Li, Michael D Weir, Xuedong Zhou, Thomas W Oates, Lei Cheng, Hockin H K Xu
OBJECTIVES: Antibacterial monomers were developed to combat oral biofilm acids and caries; however, little is known on whether quaternary ammonium monomers (QAMs) would induce drug resistance in oral bacteria. The objective of this study was to investigate the effects of new antimicrobial monomers dimethylaminohexadecyl methacrylate (DMAHDM) and dimethylaminododecyl methacrylate (DMADDM) on the induction of drug resistance in eight species of cariogenic, endodontic and periodontal bacteria for the first time...
July 26, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28748175/inhibition-of-the-quorum-sensing-system-comde-pathway-by-aromatic-1-3-di-m-tolylurea-dmtu-cariostatic-effect-with-fluoride-in-wistar-rats
#20
Gurmeet Kaur, P Balamurugan, S Adline Princy
Dental caries occurs as a result of dysbiosis among commensal and pathogenic bacteria leading to demineralization of enamel within a dental biofilm (plaque) as a consequence of lower pH in the oral cavity. In our previous study, we have reported 1,3-disubstituted ureas particularly, 1,3-di-m-tolylurea (DMTU) could inhibit the biofilm formation along with lower concentrations of fluoride (31.25 ppm) without affecting bacterial growth. In the present study, RT-qPCR analysis showed the target specific molecular mechanism of DMTU...
2017: Frontiers in Cellular and Infection Microbiology
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