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https://www.readbyqxmd.com/read/29786589/bacterial-factors-of-cariogenicity-literature-review
#1
Mariia O Faustova, Maiia M Ananieva, Yaroslav O Basarab, Oksana V Dobrobolska, Iryna M Vovk, Galina A Loban'
OBJECTIVE: Introduction: According to the 2003 WHO report, dental caries affects from 60% to 90% of school-age children and adults that makes it one of the most common diseases worldwide. The aim was to systematize data about the modern conception of plaque formation and role of microorganisms in its development. PATIENTS AND METHODS: Materials and methods: Biblosemantic, 50 medical literature sources were systematically reviewed as the material for the research...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29782890/novel-dental-adhesive-resin-with-crack-self-healing-antimicrobial-and-remineralization-properties
#2
Shichao Yue, Junling Wu, Qiang Zhang, Ke Zhang, Michael D Weir, Satoshi Imazato, Yuxing Bai, Hockin H K Xu
OBJECTIVES: Secondary caries at the tooth-restoration margins is a primary reason for restoration failure. Cracks at the margins lead to leakage which can trap bacteria, producing acids to cause caries. To date, there has been no report on developing an adhesive resin that has self-healing, antibacterial and remineralizing capabilities. The objectives of this study were to: (1) develop the first self-healing adhesive with antimicrobial and remineralizing capabilities, and (2) investigate the effects of incorporating microcapsules, dimethylaminohexadecyl methacrylate (DMAHDM) and nanoparticles of amorphous calcium phosphate (NACP) for the first time...
May 18, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29768975/arresting-dentine-caries-with-silver-diamine-fluoride-what-s-behind-it
#3
M L Mei, E C M Lo, C H Chu
Unlike other fluoride-based caries preventive agents, silver diamine fluoride (SDF) can simultaneously prevent and arrest coronal and root dentine caries. The profound clinical success of SDF has drawn many clinicians and researchers to study the mechanism of SDF in arresting dentine caries. This critical review discusses how silver and fluoride contribute to caries arrest, in terms of their effects on bacteria as well as on the mineral and organic content of dentine. Silver interacts with bacterial cell membrane and bacterial enzymes, which can inhibit bacterial growth...
May 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29768525/effects-of-a-food-enriched-with-probiotics-on-streptococcus-mutans-and-lactobacillus-spp-salivary-counts-in-preschool-children-a-cluster-randomized-trial
#4
Judy Villavicencio, Lina Maria Villegas, Maria Cristina Arango, Susana Arias, Francia Triana
Probiotics have provided benefits to general health, but they are still insufficient to dental health. This study aimed to evaluate milk supplemented with probiotic bacteria and standard milk, measured by levels of Streptococcus mutans (S. mutans) and Lactobacillus spp., in 3-4-year-old children after 9 months of intervention. The study was a triple-blind, placebo-controlled, randomized trial. The sample was composed of 363 preschoolers attending five child development centers in Cali, Colombia. They were randomized to two groups: children in the intervention group drank 200 mL of milk with Lactobacillus rhamnosus 5x106 and Bifidobacteruim longum 3x106, and children in the control group drank 200 mL of standard milk...
May 14, 2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29752268/preferred-hexoses-influence-long-term-memory-and-induction-of-lactose-catabolism-by-streptococcus-mutans
#5
Lin Zeng, Lulu Chen, Robert A Burne
Bacteria prioritize sugar metabolism via carbohydrate catabolite repression, which regulates global gene expression to optimize the catabolism of preferred substrates. Here, we report an unusual long-term memory effect in certain Streptococcus mutans strains that alters adaptation to growth on lactose after prior exposure to glucose or fructose. In strain GS-5, cells that were first cultured on fructose then transferred to lactose displayed an exceptionally long lag (>11 h) and slower growth, compared to cells first cultured on glucose or cellobiose, which displayed a reduction in lag phase by as much as 10 h...
May 11, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29749033/potential-risk-factors-for-dental-caries-in-type-2-diabetic-patients
#6
M A Almusawi, I Gosadi, R Abidia, M Almasawi, H A Khan
BACKGROUND: Diabetic patients are known to be at higher risk for dental caries. However, the role of potential risk factors such as blood glucose, salivary glucose and glycaemic control in the occurrence of dental caries in type 2 diabetes (T2D) is not clearly understood so far, and therefore, it was evaluated in this study. MATERIALS AND METHODS: This cross-sectional study was conducted on 100 T2D patients from Saudi Arabia. The caries risk assessment was evaluated using the guidelines of Caries Management by Risk Assessment (CAMBRA)...
May 11, 2018: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/29744324/effect-of-short-term-consumption-of-amul-probiotic-yogurt-containing-lactobacillus-acidophilus-la5-and-bifidobacterium-lactis-bb12-on-salivary-streptococcus-mutans-count-in-high-caries-risk-individuals
#7
Harshal Prakash Bafna, C G Ajithkrishnan, Thanveer Kalantharakath, Ricky Pal Singh, Pulkit Kalyan, Jagadishchandra Bheemasain Vathar, Hemal R Patel
Aim: This study aims to study the effect of short-term consumption of probiotic yogurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 on salivary Streptococcus mutans count in high caries risk individuals. Materials and Methods: A double-blind randomized control trial was conducted, and 70 high caries risk individuals with a salivary S. mutans count of more than 106 CFU/ml of saliva were followed for 4 weeks. Participants ingested 100 g yogurt containing L...
April 2018: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29744207/salivary-intercellular-adenosine-triphosphate-testing-in-primary-caretakers-an-examination-of-statistical-significance-versus-diagnostic-predictability
#8
Crystal Bill, Judy A Danielson, Robert S Jones
A primary caretaker is a potential reservoir of bacteria for an infant child and can be evaluated during a child's caries risk assessment. The aim of this study was to investigate an indirect method for assessing Streptococcus mutans and Streptococcus sobrinus (MS) and lactobacillus (LB) levels in a caretaker's saliva. Thirty-eight primary caretakers participated in the study to determine whether a 2-step method to assess the intracellular adenosine triphosphate (ATP) levels in saliva (saliva i-ATP method) predicted higher MS and LB levels...
December 2017: Clinical and Experimental Dental Research
https://www.readbyqxmd.com/read/29738286/self-limiting-versus-conventional-caries-removal-a-randomized-clinical-trial
#9
A H Ali, G Koller, F Foschi, M Andiappan, K D Bruce, A Banerjee, F Mannocci
A single-blind randomized controlled clinical trial in patients with deep caries and symptoms of reversible pulpitis compared outcomes from a self-limiting excavation protocol using chemomechanical Carisolv gel/operating microscope (self-limiting) versus selective removal to leathery dentin using rotary burs (control). This was followed by pulp protection with mineral trioxide aggregate (MTA) and restoration with glass ionomer cement and resin composite, all in a single visit. The pulp sensibility and periapical health of teeth were assessed after 12 mo, in addition to the differences in bacterial tissue concentration postexcavation...
May 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29731575/oral-carriage-of-cariogenic-bacteria-and-candida-albicans-in-asthmatic-adults-before-and-after-anti-asthma-medication-a-longitudinal-study
#10
R B Ashuja, D B Nandini, B Vidyasagar, R Ashwini, Mandana Donoghue, G S Madhushankari
Background: Antiasthmatic medications such as β2 agonists and corticosteroids have shown potential side effects such as increased caries risk and oral candidiasis. Studies evaluating microbial changes in adult asthmatics are very scanty in the literature. The present study aimed to evaluate the effects of asthma and its medication on cariogenic bacteria and Candida albicans in adult asthmatics. Aim and Objectives: Our aim was to evaluate and compare counts of Streptococcus mutans (SM) and lactobacilli in plaque and C...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29722800/effects-of-orthodontic-treatment-and-different-fluoride-regimens-on-numbers-of-cariogenic-bacteria-and-caries-risk-a-randomized-controlled-trial
#11
Hanna Enerbäck, Marie Möller, Cathrine Nylén, Cecilia Ödman Bresin, Ingrid Östman Ros, Anna Westerlund
Background: Caries is an undesirable side-effect of treatment with fixed orthodontic appliances. Therefore, it is crucial to understand how orthodontic treatment and different fluoride regimens affect caries risk and individual risk factors. Objective: To evaluate the effects of orthodontic treatment and different fluoride regimens on caries risk and caries risk factors, including cariogenic bacteria. Trial design: Three-armed, parallel group, randomized, controlled trial...
May 2, 2018: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29720648/structural-basis-for-dual-mode-inhibition-of-the-abc-transporter-msba
#12
Hoangdung Ho, Anh Miu, Mary Kate Alexander, Natalie K Garcia, Angela Oh, Inna Zilberleyb, Mike Reichelt, Cary D Austin, Christine Tam, Stephanie Shriver, Huiyong Hu, Sharada S Labadie, Jun Liang, Lan Wang, Jian Wang, Yan Lu, Hans E Purkey, John Quinn, Yvonne Franke, Kevin Clark, Maureen H Beresini, Man-Wah Tan, Benjamin D Sellers, Till Maurer, Michael F T Koehler, Aaron T Wecksler, James R Kiefer, Vishal Verma, Yiming Xu, Mireille Nishiyama, Jian Payandeh, Christopher M Koth
The movement of core-lipopolysaccharide across the inner membrane of Gram-negative bacteria is catalysed by an essential ATP-binding cassette transporter, MsbA. Recent structures of MsbA and related transporters have provided insights into the molecular basis of active lipid transport; however, structural information about their pharmacological modulation remains limited. Here we report the 2.9 Å resolution structure of MsbA in complex with G907, a selective small-molecule antagonist with bactericidal activity, revealing an unprecedented mechanism of ABC transporter inhibition...
May 2, 2018: Nature
https://www.readbyqxmd.com/read/29720328/evaluation-of-bacterial-flora-composition-on-teeth-and-periodontal-tissues-in-patients-in-treatment-with-rapid-palatal-expander
#13
D De Santis, P Pancera, U Luciano, F Gelpi, G Causarano, D Formentini, M Marchiori, M L Lanaro, G Puddu, S Sinigaglia, D Bertossi, P Faccioni, P F Nocini
Patients in treatment with rapid palatal expander (RPE) require professional assistance and more meticulous instructions on oral hygiene, since this appliance predisposes to gingivitis and caries. The aim of this work is to analyse the variability of the oral microbial flora found in patients in treatment with RPE with occlusal acrylic splint. It was also investigated whether the association of an antimicrobial mouthwash was useful during orthodontic treatment or whether regular and specific home oral hygiene manoeuvres were sufficient to maintain a good plaque control...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29710488/human-oral-microbiota-and-its-modulation-for-oral-health
#14
REVIEW
Yangheng Zhang, Xiang Wang, Houxuan Li, Can Ni, Zhibin Du, Fuhua Yan
The oral microbiome is an important part of the human microbiome. The oral cavity contains several significantly different niches with distinct microbial communities. A wide range of microorganisms inhabit the human oral cavity, including bacteria, fungi, viruses, archaea and protozoa. These microorganisms form a complex ecological community that influences oral and systemic health. The most prevalent oral diseases, dental caries and periodontal diseases, are microbiota-associated diseases. Moreover, increasing evidences have supported that many systemic diseases are associated with disturbances in the oral ecosystem, such as diabetes, cardiovascular diseases and tumors...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29698142/contribution-of-streptococcus-mutans-virulence-factors-and-saliva-agglutinating-capacity-to-caries-susceptibility-in-children-a-preliminary-study
#15
Eloa Ramalho de Camargo, Jonas Bitencourt Canalle, Rodriguo Capozzoli, Tanila Wood Dos Santos, Margareth Bulhman Ballini, Lucio Fabio Caldas Ferraz, Thaís Manzano Parisotto, Michelle Darrieux
BACKGROUND: Many factors contribute to caries development in humans, such as diet, host factors - including different saliva components - and the presence of acidogenic bacteria in the dental biofilm, particularly Streptococcus mutans (S. mutans). Despite the influence of S. mutans in caries, this bacterium is also prevalent among healthy individuals, suggesting the contribution of genetic variation on the cariogenic potential. Based on this hypothesis, the present work investigated the influence of S...
April 26, 2018: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29682851/effects-of-papacarie-on-children-with-dental-caries-in-primary-teeth-a-systematic-review-and-meta-analysis
#16
REVIEW
Yuejia Deng, Ge Feng, Bo Hu, Yunchun Kuang, Jinlin Song
BACKGROUND: Caries in primary teeth hinder the child to bite and chew and influence their development. Papacarie has the characteristics of selective removal of decayed tissue and can preserve healthy dentine to the maximum, but its efficiency has not been critically evaluated compared to conventional method. AIM: This review is aiming at comparing the Papacarie and traditional method in caries removal in primary dental caries with children. DESIGN: Comprehensive literature searching at PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science to January 2018...
April 23, 2018: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/29682545/curcumin-as-a-promising-antibacterial-agent-effects-on-metabolism-and-biofilm-formation-in-s-mutans
#17
Bingchun Li, Xinlong Li, Huancai Lin, Yan Zhou
Streptococcus mutans (S. mutans) has been proved to be the main aetiological factor in dental caries. Curcumin, a natural product, has been shown to exhibit therapeutic antibacterial activity, suggesting that curcumin may be of clinical interest. The objective of this study is to evaluate the inhibitory effects of curcumin on metabolism and biofilm formation in S. mutans using a vitro biofilm model in an artificial oral environment. S. mutans biofilms were treated with varying concentrations of curcumin. The biofilm metabolism and biofilm biomass were assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay and the crystal violet assay...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29680724/human-dental-pulp-cells-express-cellular-markers-for-inflammation-and-hard-tissue-formation-in-response-to-bacterial-information
#18
Akina Sugiuchi, Yousuke Sano, Masahiro Furusawa, Shu Abe, Takashi Muramatsu
INTRODUCTION: Lipopolysaccharide (LPS) is a major component of the outer membranes of gram-negative bacteria associated with deep dental caries and pulpitis. When bacteria invade dentinal tubes and dentin is continually destroyed, tertiary dentin is formed by preexisting odontoblasts. However, the relationship between LPS and tertiary dentin formation remains unclear. We investigated whether LPS stimulation induces the formation of hard tissue in human dental pulp cells (hDPCs). METHODS: Immortalized hDPCs were cultured, and Escherichia coli-derived LPS (1 μg/mL) was incorporated into the culture medium...
April 18, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29667264/metagenomic-analysis-of-oral-microbiome-in-young-children-aged-6-8-y-living-in-a-rural-isolated-chinese-province
#19
Yuan Xu, Yuhuan Jia, Liang Chen, Wenming Huang, Deqin Yang
BACKGROUND: The mixed dentition is an important transition period from primary teeth. to permanent teeth. However, the caries prevalence of first permanent molar in mixed dentitions was about 30%, which almost represent the caries rate of permanent teeth in this period of time. Therefore, we assessed the oral bacterial profiles in young children (age 6-8) with mixed dentition with or without first molar caries for providing the research basis of caries etiology. METHODS: We collected samples of supragingival plaque and saliva from the children living in Guizhou, a rural isolated province in China...
April 18, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29662145/the-ecology-and-diversity-of-microbial-eukaryotes-in-geothermal-springs
#20
Angela M Oliverio, Jean F Power, Alex Washburne, S Craig Cary, Matthew B Stott, Noah Fierer
Decades of research into the Bacteria and Archaea living in geothermal spring ecosystems have yielded great insight into the diversity of life and organismal adaptations to extreme environmental conditions. Surprisingly, while microbial eukaryotes (protists) are also ubiquitous in many environments, their diversity across geothermal springs has mostly been ignored. We used high-throughput sequencing to illuminate the diversity and structure of microbial eukaryotic communities found in 160 geothermal springs with broad ranges in temperature and pH across the Taupō Volcanic Zone in New Zealand...
April 16, 2018: ISME Journal
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