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https://www.readbyqxmd.com/read/29146379/lt-adjuvant-modulates-epitope-specificity-and-improves-the-efficacy-of-murine-antibodies-elicited-by-sublingual-vaccination-with-the-n-terminal-domain-of-streptococcus-mutans-p1
#1
Milene Tavares Batista, Ewerton Lucena Ferreira, Gisela de Souza Pereira, Phillip Stafford, Denicar Lina Nascimento Fabris Maeda, Juliana Falcão Rodrigues, L Jeannine Brady, Stephen Albert Johnston, Luís Carlos de Souza Ferreira, Rita de Cássia Café Ferreira
In this study, we evaluated the immunogenicity, protective efficacy and peptide-based immune signatures of antibodies raised in mice after sublingual immunization with a recombinant form of the P1 (aka AgI/II, PAc) adhesin (P139-512) of Streptococcus mutans, a major etiological agent of dental caries. Sublingual administration of P139-512 in combination with the mucosal adjuvant LTK4R (a derivative of heat-labile LT toxin) induced strong and long-lasting systemic and mucosal immune responses. Incorporation of the adjuvant resulted in an enhancement of the anti-adhesive and anti-colonization activity against S...
November 13, 2017: Vaccine
https://www.readbyqxmd.com/read/29143221/controlling-streptococcus-mutans-and-staphylococcus-aureus-biofilms-with-direct-current-and-chlorhexidine
#2
Hao Wang, Dacheng Ren
Microbial biofilms formed on biomaterials are major causes of chronic infections. Among them, Gram-positive bacteria Streptococcus mutans and Staphylococcus aureus are important pathogens causing infections associated with dental caries (tooth-decay) and other medical implants. Unfortunately, current antimicrobial approaches are ineffective in disrupting established biofilms and new methods are needed to improve the efficacy. In this study, we report that the biofilm cells of S. mutans and S. aureus can be effectively killed by low-level direct current (DC) and through synergy in concurrent treatment with DC and chlorhexidine (CHX) at low concentrations...
November 15, 2017: AMB Express
https://www.readbyqxmd.com/read/29140971/effect-of-s-mutans-and-s-sanguinis-on-growth-and-adhesion-of-p-gingivalis-and-their-ability-to-adhere-to-different-dental-materials
#3
Yan Tu, Xiaolong Ling, Yadong Chen, Yuan Wang, Na Zhou, Hui Chen
BACKGROUND Caries and periodontal diseases are caused by the biofilm formed by caries- and periodontal disease-related bacteria. Specific biofilms could be formed on different filling materials in oral cavity. Thus, to explore the inhibition effect of restorative filling materials on biofilm formation is of great significance in the treatment of caries and periodontal disease. MATERIAL AND METHODS The supernatants of S. mutans, S. sanguinis, and P. gingivalis suspension were combined with BHI broth. After 24 h, the live P...
November 15, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29139168/hunter-gatherer-dental-pathology-do-historic-accounts-of-aboriginal-australians-correspond-to-the-archeological-record-of-dental-disease
#4
Judith Littleton
OBJECTIVES: Studies of hunter-gatherer oral pathology, particularly in Australia, often focus upon dental wear and caries or assume that historic studies of Aboriginal people reflect the precontact past. Consequently the range of population variation has been underestimated. In this paper dental pathology from human remains from Roonka are compared with a model of dental pathology derived from historic studies. The aim is to identify aspects of dental pathology indicative of regional or intra-population diversity...
November 15, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/29138112/dentists-decision-strategies-for-suspicious-occlusal-caries-lesions-in-a-national-dental-pbrn-study
#5
Sonia K Makhija, Michael E Robinson, James D Bader, Daniel A Shugars, Mark S Litaker, Hong R Im, D Brad Rindal, Daniel J Pihlstrom, Cyril Meyerowitz, Valeria V Gordan, Meredith K Buchberg, Gregg H Gilbert
OBJECTIVE: Case presentations (vignettes) were completed by dentists in the National Dental Practice-Based Research Network study "Decision Aids for the Management of Suspicious Occlusal Caries Lesions (SOCLs)". The objective was to determine dentists' decision strategies for SOCLs). METHODS: 107 dentists viewed a series of 16 vignettes that represented all combinations of 4 clinical cues: color, luster, lesion roughness, and patient-level caries risk. Each vignette included a patient description and a photograph of a tooth presenting the 4 cues...
November 11, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29136361/dental-status-in-nursing-home-residents-with-domiciliary-dental-care-in-sweden
#6
P Andersson, S Renvert, P Sjogren, M Zimmerman
OBJECTIVE: To describe the dental health status of elderly people in nursing homes receiving domiciliary dental care. DESIGN: Case note review. CLINICAL SETTING: Nursing homes in 8 Swedish counties. PARTICIPANTS: Care dependent elderly people (≥65 years). METHODS: Clinical data, including the number of remaining natural teeth, missing and decayed teeth (manifest dental caries) and root remnants, recorded by dentists according to standard practices...
November 10, 2017: Community Dental Health
https://www.readbyqxmd.com/read/29136360/investigating-socioeconomic-position-in-dental-caries-and-traumatic-dental-injury-among-children-in-quebec
#7
P Da Rosa, Marie-Claude Rousseau, A Edasseri, M Henderson, B Nicolau
OBJECTIVES: Socioeconomic position (SEP) is inversely associated with most oral health outcomes, but the patterns of association may vary depending on the specific outcome. We estimated associations between SEP and two oral health outcomes, dental caries and traumatic dental injuries (TDI), in Quebec children. METHODS: We used data from the baseline visit of the QUALITY (QUebec Adipose and Lifestyle Investigation in Youth) Cohort, an ongoing study in Montreal and Quebec, Canada...
November 10, 2017: Community Dental Health
https://www.readbyqxmd.com/read/29135948/effect-of-a-lactobacillus-salivarius-probiotic-on-a-double-species-streptococcus-mutans-and-candida-albicans-caries-biofilm
#8
Wirginia Krzyściak, Dorota Kościelniak, Monika Papież, Palina Vyhouskaya, Katarzyna Zagórska-Świeży, Iwona Kołodziej, Beata Bystrowska, Anna Jurczak
The aim of the study was to evaluate the anti-cariogenic effects of Lactobacillus salivarius by reducing pathogenic species and biofilm mass in a double-species biofilm model. Coexistence of S. mutans with C. albicans can cause dental caries progression or recurrence of the disease in the future. Fifty-nine children with diagnosed early childhood caries (ECC) were recruited onto the study. The condition of the children's dentition was defined according to the World Health Organization guidelines. The participants were divided into children with initial enamel demineralization and children showing dentin damage...
November 14, 2017: Nutrients
https://www.readbyqxmd.com/read/29132377/the-development-and-psychometric-properties-of-the-arabic-version-of-the-child-oral-health-impact-profile-short-form-cohip-sf-19
#9
A A Arheiam, S R Baker, L Ballo, I Elareibi, S Fakron, R V Harris
BACKGROUND: This study aims to cross-culturally adapt the original English-language COHIP-SF 19 to Arabic culture and to test its psychometric properties in a community sample. METHODS: The Arabic COHIP-SF 19 was developed and its psychometric properties were examined in a population-based sample of 876 schoolchildren who were aged 12 years of age, in Benghazi, Libya. The Arabic COHIP-SF 19 was tested for its internal consistency, reproducibility, construct validity, factorial validity and floor as well as ceiling effects...
November 13, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29126489/dental-treatment-planning-for-the-patient-with-oral-cancer
#10
REVIEW
Lauren E Levi, Rajesh V Lalla
Oral cancer therapy is associated with a multitude of head and neck sequelae that includes, but is not limited to, hyposalivation, increased risk for dental caries, osteoradionecrosis of the jaw, radiation fibrosis syndrome, mucositis, chemotherapy-induced neuropathy, dysgeusia, dysphagia, mucosal lesions, trismus, and infections. Preparing a comprehensive treatment plan for patients undergoing cancer therapy is essential to help minimize their risks for developing these oral and dental complications. In addition, dentists must take into account a patient's ongoing oncologic therapy for those patients who present to the dentist while concurrently receiving cancer treatment...
January 2018: Dental Clinics of North America
https://www.readbyqxmd.com/read/29125139/salivary-proteins-and-microbiota-as-biomarkers-for-early-childhood-caries-risk-assessment
#11
REVIEW
Abdullah S Hemadi, Ruijie Huang, Yuan Zhou, Jing Zou
Early childhood caries (ECC) is a term used to describe dental caries in children aged 6 years or younger. Oral streptococci, such as Streptococcus mutans and Streptococcus sorbrinus, are considered to be the main etiological agents of tooth decay in children. Other bacteria, such as Prevotella spp. and Lactobacillus spp., and fungus, that is, Candida albicans, are related to the development and progression of ECC. Biomolecules in saliva, mainly proteins, affect the survival of oral microorganisms by multiple innate defensive mechanisms, thus modulating the oral microflora...
November 10, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/29124950/factors-associated-with-dental-caries-periodontitis-and-intra-oral-lesions-in-individuals-with-hiv-aids
#12
Anderson Jambeiro de Souza, Isaac Suzart Gomes-Filho, Carlos Alberto Lima da Silva, Johelle de Santana Passos-Soares, Simone Seixas da Cruz, Soraya Castro Trindade, Ana Claudia Morais Godoy Figueiredo, Yvonne de Paiva Buischi, Gregory J Seymour, Eneida de Moraes Marcílio Cerqueira
This study aimed to investigate the factors associated with oral diseases in individuals with HIV/AIDS. A cross sectional study was carried out which included 312 individuals registered in the Specialized Care Services for HIV/AIDS in three municipalities of the State of Bahia: Feira de Santana, Santo Antonio de Jesus and Juazeiro, Brazil. Socioeconomic-demographic characteristics related to life style and to dental caries, periodontitis and intra-oral mucosal lesions were investigated in patients with HIV/AIDS infection...
November 10, 2017: AIDS Care
https://www.readbyqxmd.com/read/29124888/differential-oxidative-stress-tolerance-of-streptococcus-mutans-isolates-affects-competition-in-an-ecological-mixed-species-biofilm-model
#13
Yuan Liu, Sara R Palmer, Hsiaochi Chang, Ashton N Combs, Robert A Burne, Hyun Koo
Streptococcus mutans strongly influences the development of pathogenic biofilms associated with dental caries. Our understanding of S. mutans behavior in biofilms is based on a few well-characterized laboratory strains; however, individual isolates vary widely in genome content and virulence-associated phenotypes, such as biofilm formation and environmental stress sensitivity. Using an ecological biofilm model, we assessed the impact of co-cultivation of several S. mutans isolates with Streptococcus oralis and Actinomyces naeslundii on biofilm composition following exposure to sucrose...
November 10, 2017: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/29122096/association-between-bmi-and-dental-caries-among-school-children-and-adolescents-in-jiangsu-province-china
#14
Wei Li, Taha Hussein Musa, Rong Gao, Xiao Shan Li, Wei Xiang Wang, Lei Hong, Ping Min Wei
Obesity and dental caries are increasing epidemics, especially among children and adolescents. This epidemiological observational cross-sectional study was conducted to assess the possible association between body mass index (BMI) and dental caries among 111,792 school children and adolescents in Jiangsu Province. We found that 13.14% participants of the study sample were overweight, and 7.37% were obese. The prevalence of dental caries was 12.95% in overweight and 7.89% in obese students. There were significant differences in caries prevalence by sex, region, age group, and BMI...
October 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29122090/prevalence-and-years-of-life-lost-due-to-disability-from-dental-caries-among-children-and-adolescents-in-western-china-1990-2015
#15
Zhuo Wang, Ying Deng, Shi Wei Liu, Jun He, Kui Ji, Xin Ying Zeng, Shu Juan Yang, Xin Yin Xu, Yu Luo, Mai Geng Zhou, Jian Xin Zhang
OBJECTIVE: To analyze the prevalence and years lived with disability (YLD) from dental caries among children and adolescents and the time trends over the past two decades in Sichuan province, the largest province in west China. METHODS: Based on the Global Burden of Disease Study 2015 (GBD2015), which systematically assessed the epidemiological characteristics of major diseases and their transitions by country and region from 1990 to 2015, we extracted the estimated results for China...
2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29119741/supervised-toothbrushing-programs-in-primary-schools-and-early-childhood-settings-a-scoping-review
#16
V Dickson-Swift, A Kenny, M Gussy, A M de Silva, J Farmer, S Bracksley-O'Grady
OBJECTIVE: In this article we report the findings of a scoping review that aimed to identify and summarise the range of programs and guidelines available for toothbrushing programs in schools and early childhood settings. Dental caries is one of the most common preventable diseases affecting children worldwide. Untreated caries can impact on child health and wellbeing, development, socialisation and school attendance. Supervised toothbrushing programs in schools and other early childhood settings can be effective in improving the oral health of young children...
November 10, 2017: Community Dental Health
https://www.readbyqxmd.com/read/29119417/effect-of-methylene-blue-mediated-antimicrobial-photodynamic-therapy-on-dentin-caries-microcosms
#17
Daniela Alejandra Cusicanqui Méndez, Eliezer Gutierrez, Evandro José Dionísio, Thaís Marchini Oliveira, Marília Afonso Rabelo Buzalaf, Daniela Rios, Maria Aparecida Andrade Moreira Machado, Thiago Cruvinel
Antimicrobial photodynamic therapy (aPDT) has been proposed as an adjuvant treatment of dental caries, although there are no well-defined protocols to its clinical application. This study aimed to evaluate the influence of aPDT on the viability of microorganisms, vitality of biofilms, and lactic acid production of dentin caries microcosms. Biofilms were grown on bovine dentin discs in anaerobic conditions at 37 °C for 5 days, inoculating infected carious dentin in modified McBain medium plus 1% sucrose. The biofilms were treated by the combination of deionized water or 100 mg L(-1) methylene blue (MB) with 0, 37...
November 8, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29119318/global-oral-health-status-of-athletes-with-intellectual-disabilities
#18
Luc Marks, Allen Wong, Steven Perlman, Amy Shellard, Carla Fernandez
BACKGROUND: The aim of this study is to identify the oral health status and treatment needs of Special Olympics athletes with intellectual disabilities from 181 countries by the assessment of oral health parameters and differences between world regions. MATERIAL AND METHODS: Data were collected through interview and oral examinations within the Healthy Athletes Screening. These data were analysed with descriptive statistics of oral health parameters of athletes from Africa, Asia Pacific, East Asia, Europe/Eurasia, Latin America, Middle East North Africa (MENA) and North America...
November 9, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29118278/oral-health-status-of-independent-older-adults-in-texas-an-observational-study-comparing-urban-and-rural-areas
#19
Julie L Martin, Linda D Boyd, Helena Tapias-Perdigón, Lisa M LaSpina
Purpose: The purpose of this study was to assess the oral health needs of community-dwelling older adults participating in congregate meal centers and to determine whether differences exist in the oral health needs of older adult populations residing in urban versus rural communities in the state of Texas.Methods: Study participants were recruited at 6 congregate meal centers located in identified rural and urban communities in the greater metropolitan area of Austin, Texas. (N=78) Participants completed a validated, modified questionnaire containing 20 items on the following topics: self-reported oral health, tooth loss, dental insurance, frequency of dental visits, time since last dental visit, access to dental care, dry mouth, and oral cancer screening...
October 2017: Journal of Dental Hygiene: JDH
https://www.readbyqxmd.com/read/29118084/perceptions-of-registered-dental-hygienists-in-alternative-practice-regarding-silver-diamine-fluoride
#20
Salina K Chhokar, Lory Laughter, Dorothy J Rowe
Purpose: Silver diamine fluoride (SDF) is an inexpensive, non-invasive, antimicrobial liquid used to treat carious lesions and decrease sensitivity. The purpose of this study was to assess the perceptions of registered dental hygienists in alternative practice (RDHAP) regarding the use of SDF to treat dental caries.Methods: A 16-item survey designed to evaluate RDHAP's familiarity and perceptions of SDF was electronically distributed to 222 RDHAPs practicing in the state of California. A survey research software program collected and tabulated responses, calculated response frequencies for each survey item, and determined statistical relationships among variables, using cross tabulation analysis...
August 2017: Journal of Dental Hygiene: JDH
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