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Richard B Lipton, Peter J Goadsby
No abstract text is available yet for this article.
June 15, 2018: Neurology
Eric Z Herring, Matthew R Peck, Caroline E Vonck, Gabriel A Smith, Thomas E Mroz, Michael P Steinmetz
OBJECTIVE Spine surgeons in the United States continue to be overwhelmed by an aging population, and patients are waiting weeks to months for appointments. With a finite number of clinic visits per surgeon, analysis of referral sources needs to be explored. In this study, the authors evaluated patient referrals and their yield for surgical volume at a tertiary care center. METHODS This is a retrospective study of new patient visits by the spine surgery group at the Cleveland Clinic Center for Spine Health from 2011 to 2016...
June 15, 2018: Journal of Neurosurgery. Spine
Claudio Capra
No abstract text is available yet for this article.
June 2018: Neurological Sciences
Susan P Mollan, Brendan Davies, Nick C Silver, Simon Shaw, Conor L Mallucci, Benjamin R Wakerley, Anita Krishnan, Swarupsinh V Chavda, Satheesh Ramalingam, Julie Edwards, Krystal Hemmings, Michelle Williamson, Michael A Burdon, Ghaniah Hassan-Smith, Kathleen Digre, Grant T Liu, Rigmor Højland Jensen, Alexandra J Sinclair
The aim was to capture interdisciplinary expertise from a large group of clinicians, reflecting practice from across the UK and further, to inform subsequent development of a national consensus guidance for optimal management of idiopathic intracranial hypertension (IIH). METHODS: Between September 2015 and October 2017, a specialist interest group including neurology, neurosurgery, neuroradiology, ophthalmology, nursing, primary care doctors and patient representatives met. An initial UK survey of attitudes and practice in IIH was sent to a wide group of physicians and surgeons who investigate and manage IIH regularly...
June 14, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Benjamin Courchia, Waleed Kurtom, Alyssa Pensirikul, Teresa Del-Moral, Maria Buch
Neonatal seizures represent a significant health burden on the term and preterm neonatal population and are linked to poor long-term neurodevelopmental outcomes. Currently, there are no US Food and Drug Administration-approved antiepileptic drugs for neonates, and authors of the medical literature have yet to reach a consensus on the most adequate approach to neonatal seizures. Topiramate is readily used in the adult and older pediatric population for the management of migraines and partial-onset seizures. Topiramate continues to gain favor among pediatric neurologists who often recommend this medication as a third-line treatment of neonatal seizures...
June 14, 2018: Pediatrics
J F Vázquez-Costa, M Martínez-Molina, M Fernández-Polo, V Fornés-Ferrer, M Frasquet-Carrera, T Sevilla-Mantecón
INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is an insidious, clinically heterogeneous neurodegenerative disease associated with a diagnostic delay of approximately 12 months. No study conducted to date has analysed the diagnostic pathway in Spain. METHODS: We gathered data on variables related to the diagnostic pathway and delay for patients diagnosed with ALS between October 2013 and July 2017. RESULTS: The study included 143 patients with ALS (57% men; 68% spinal onset)...
June 11, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
Xinxin Ma, Wen Su, Haibo Chen
RATIONALE: Reversible splenial lesion syndrome (RESLES) is a reversible condition with an excellent prognosis in most patients. The clinical features include altered states of consciousness, delirium, headache, and seizures, but no callosal disconnection syndromes have been described in RESLES. PATIENT CONCERNS: We presented a 57-year-old patient with alien hand syndrome, autotopagnosia, gait disorders, and left ideomotor apraxia after blood transfusion. The brain magnetic resonance imaging (MRI) showed a few regions with high signal intensity in the genu, body, and splenium of the right corpus callosum on diffusion weighted images...
June 2018: Medicine (Baltimore)
Ari Berkowitz
John Hughlings Jackson, the 19th-century British neurologist, first described what are today called Jacksonian seizures. He is generally associated with somatotopy, the idea that neighboring brain regions control neighboring body parts, as later represented pictorially in Wilder Penfield's "homunculus," or little man in the brain. Jackson's own views, however, were quite different, though this is seldom appreciated. In an 1870 article, Jackson advanced the hypotheses that each region of the cerebrum controls movements of multiple body parts, but to different degrees, and that the "march" of movements that typically occurs during Jacksonian seizures is caused by the downstream connections of the overactive neurons at the seizure focus, rather than a somatotopic organization of the cerebrum...
June 1, 2018: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
Zhong-Ying Gong, Gao-Peng Lv, Li-Na Gao, Yi Lu, Jie Guo, Da-Wei Zang
BACKGROUND: There are no reliable biomarkers that could evaluate the disease burden in amyotrophic lateral sclerosis (ALS). OBJECTIVES: The aim of our study is to evaluate the changes in cerebrospinal fluid (CSF) and serum neurofilament subunit L (NF-L) in patients with ALS and to analyze the correlations between the levels of NF-L and clinical parameters. METHOD: CSF and serum samples were obtained from 80 ALS patients and 40 controls. The levels of NF-L in CSF and serum were assessed, and disease progression parameters including duration, revised ALS Functional Rating Scale (ALSFRS-r) score, disease progression rate (DPR), upper motor neuron (UMN) score, and survival were analyzed by registered neurologists...
June 13, 2018: Neuro-degenerative Diseases
Gustavo Koíti Kondo, Carla Caroline Schramm, Max Rainer Rosado Novaes, Hélio Afonso Ghizoni Teive
Jules Joseph Dejerine (1849-1917) became renowned for his many contributions to neurology, including his anatomical and anatomo-functional studies, particularly those in the field of language and the peripheral nervous system. A disciple of Vulpian and a rival of Charcot, Dejerine progressed rapidly in the academic world, reaching the peak of his career in 1911, when he was appointed to the chair of Nervous System Diseases at the Salpêtrière Hospital after defeating Pierre Marie (1853-1940), one of the most distinguished pupils of Jean-Martin Charcot (1825-1893)...
May 2018: Arquivos de Neuro-psiquiatria
Sotirios Prapas, Antonio Maria Calafiore, Konstantinos P Katsavrias, Ioannis A Panagiotopoulos, Ioannis N Linardakis, Fabrizio Tancredi, Massimiliano Foschi, Michele Di Mauro
OBJECTIVES: Our goal was to compare the observed and the expected rates of postoperative cerebrovascular accidents (CVA) in a large cohort of consecutive patients undergoing off-pump coronary artery bypass grafting (CABG) using the ∏-circuit as a no-touch technique. METHODS: From January 2001 to May 2016, 3081 patients were consecutively submitted to an off-pump CABG operation using the ∏-circuit. A CVA was defined as a neurological deficit, lasting less (transient ischaemic attack) or more (stroke) than 24 h, diagnosed by a neurologist and confirmed by a computed tomography or magnetic resonance imaging scan of the brain...
June 11, 2018: European Journal of Cardio-thoracic Surgery
Tone Bruvik Heinskou, Per Rochat, Stine Maarbjerg, Frauke Wolfram, Jannick Brennum, Jes Olesen, Lars Bendtsen
Introduction There is a lack of high-quality prospective, systematic studies using independent assessors of outcome of microvascular decompression as treatment for trigeminal neuralgia. Methods Clinical characteristics and outcome data were recorded prospectively from consecutive classical trigeminal neuralgia patients, using standardized interviews. Degree of neurovascular contact was evaluated by a 3.0 Tesla MRI blinded to symptomatic side. Patients were assessed before and 12 months after surgery by a neurologist...
January 1, 2018: Cephalalgia: An International Journal of Headache
Niraj M Shanbhag, Michael D Geschwind, John J DiGiovanna, Catherine Groden, Rena Godfrey, Matthew J Yousefzadeh, Erin A Wade, Laura J Niedernhofer, May Christine V Malicdan, Kenneth H Kraemer, William A Gahl, Camilo Toro
Objective: To describe the features of 2 unrelated adults with xeroderma pigmentosum complementation group F (XP-F) ascertained in a neurology care setting. Methods: We report the clinical, imaging, molecular, and nucleotide excision repair (NER) capacity of 2 middle-aged women with progressive neurodegeneration ultimately diagnosed with XP-F. Results: Both patients presented with adult-onset progressive neurologic deterioration involving chorea, ataxia, hearing loss, cognitive deficits, profound brain atrophy, and a history of skin photosensitivity, skin freckling, and/or skin neoplasms...
June 2018: Neurology. Genetics
Liciane P Valarelli, Anne M B Corradi, Thaís H Grechi, Alan L Eckeli, Davi C Aragon, Daniel S Küpper, Leila A Almeida, Heidi H Sander, Cláudia M de Felício, Luciana V V Trawitzki, Fabiana C P Valera
BACKGROUND: Obstructive Sleep Apnea Syndrome (OSAS) is believed to be associated with craniofacial and neuromuscular changes, although the interplay among these variables still is poorly recognized. OBJECTIVE: to identify hyoid, muscular and swallowing changes associated with OSAS, and to correlate these alterations with OSAS severity. METHODS: Cross-sectional study, in a tertiary referral center. Seventy-two adult individuals participated in this study: 12 controls (without apnea) and 60 patients with apnea (mild, moderate and severe OSAS - 20 individuals in each group)...
June 11, 2018: Journal of Oral Rehabilitation
Arno de Wilde, Wiesje M van der Flier, Wiesje Pelkmans, Femke Bouwman, Jurre Verwer, Colin Groot, Marieke M van Buchem, Marissa Zwan, Rik Ossenkoppele, Maqsood Yaqub, Marleen Kunneman, Ellen M A Smets, Frederik Barkhof, Adriaan A Lammertsma, Andrew Stephens, Erik van Lier, Geert Jan Biessels, Bart N van Berckel, Philip Scheltens
Importance: Previous studies have evaluated the diagnostic effect of amyloid positron emission tomography (PET) in selected research cohorts. However, these research populations do not reflect daily practice, thus hampering clinical implementation of amyloid imaging. Objective: To evaluate the association of amyloid PET with changes in diagnosis, diagnostic confidence, treatment, and patients' experiences in an unselected memory clinic cohort. Design, Setting, and Participants: Amyloid PET using fluoride-18 florbetaben was offered to 866 patients who visited the tertiary memory clinic at the VU University Medical Center between January 2015 and December 2016 as part of their routine diagnostic dementia workup...
June 11, 2018: JAMA Neurology
Urs Strohmaier, Felix Keller, Ingo Kilimann, Bernhard Michalowsky, Diana Wucherer, Ina Zwingmann, Stefan Teipel, Wolfgang Hoffmann, Jochen René Thyrian
BACKGROUND: The current guidelines imply that basic medical diagnostics for dementia should be provided by general practitioners in cooperation with other specialists such as neurologists and psychiatrists. OBJECTIVES: The aims of this paper were to 1) compare the dementia patients of general practice residents whose care is co-managed by neurology/psychiatry residents with those whose care is not; 2) identify the patient variables associated with the utilization of neurological and psychiatric specialists; and 3) describe the frequency of imaging use a for dementia patients in primary care...
June 4, 2018: Journal of Alzheimer's Disease: JAD
Maurizio Pocchiari, Jean Manson
This is the first volume of the Handbook of Clinical Neurology totally devoted to prion diseases. The reason for this choice is to inform neurologists and neuroscientists about the remarkable advances that this field has made in the diagnosis of human and animal prion diseases, understanding the pathogenesis of disease, and in the development of novel in vivo and in vitro models. In recent years, the knowledge of prion replication and mechanisms of prion spreading within the brain and peripheral organs of infected people has also become important for understanding other protein misfolded diseases of the brain, such as Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis...
2018: Handbook of Clinical Neurology
Rebecca Ichord, Faye S Silverstein, Beth S Slomine, Russell Telford, James Christensen, Richard Holubkov, J Michael Dean, Frank W Moler
OBJECTIVE: To implement a standardized approach to characterize neurologic outcomes among 12-month survivors in the Therapeutic Hypothermia after Pediatric Cardiac Arrest (THAPCA) trials. METHODS: Two multicenter trials enrolled children age 48 hours to 18 years who remained comatose after cardiac arrest (CA) occurring out-of-hospital (THAPCA-OH, NCT00878644) or in-hospital (THAPCA-IH, NCT00880087); patients were randomized to therapeutic hypothermia or therapeutic normothermia...
June 8, 2018: Neurology
Anne E Keller, Robyn Whitney, Shelly-Anne Li, Michael S Pollanen, Elizabeth J Donner
OBJECTIVE: To determine the incidence of sudden unexpected death in epilepsy (SUDEP) in children in Ontario, Canada. METHODS: Cases of suspected pediatric SUDEP occurring between January 1, 2014, and December 31, 2015, in Ontario, Canada, were eligible for inclusion. Potential cases were identified through 3 sources: a national pediatrician surveillance program, child neurologist report, and screening of provincial forensic autopsies. Cases were classified as definite, definite plus, probable, possible, and near/near plus according to criteria described by Nashef et al...
June 8, 2018: Neurology
Sunil Munshi, Senthil K Raghunathan, Ileana Lindeman, Ashit K Shetty
We describe a case of a 49-year-old man who presented with recurrent strokes in the left middle cerebral artery territory, manifesting with dysphasia, higher cognitive deficits, motor deficits and subsequent infarcts in the right middle cerebral and anterior cerebral artery territories, manifesting with seizures, behavioural and social issues. A key issue of the case was the diagnostic difficulty faced by the physicians. 'Meningovascular syphilis' was subsequently confirmed and appropriate treatment was given but there was subsequent relapse with worsening of the symptoms...
June 8, 2018: BMJ Case Reports
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