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https://www.readbyqxmd.com/read/29346671/hematological-analysis-in-thai-samples-with-deletional-and-nondeletional-hbh-diseases
#1
Sakorn Pornprasert, Nur-Afsan Salaeh, Monthathip Tookjai, Manoo Punyamung, Panida Pongpunyayuen, Kallayanee Treesuwan
Objectives: To compare hematological parameters between deletional and nondeletional HbH diseases, and to investigate the correlation between HbH levels and hematological parameters within these 2 groups. Methods: Samples of 43 deletional HbH diseases, which included 39 --SEA/-α3.7, 4 - -SEA/-α4.2, and 22 nondeletional HbH diseases (- -SEA/αcsα), were used in this study. Correlations between HbH levels and hematological parameters within these 2 groups were analyzed...
January 13, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29341506/impact-of-preoperative-anemia-on-outcomes-in-patients-undergoing-curative-resection-for-gastric-cancer-a-single-institution-retrospective-analysis-of-2163-chinese-patients
#2
Xuechao Liu, Haibo Qiu, Yuying Huang, Dazhi Xu, Wei Li, Yuanfang Li, Yingbo Chen, Zhiwei Zhou, Xiaowei Sun
We sought to evaluate whether preoperative anemia was an important determinant of survival in gastric cancer (GC). A single institution cohort of 2163 GC patients who underwent curative resection were retrospectively analyzed. Anemia was defined as a preoperative hemoglobin level <120 g/L in males and <110 g/L in females. Overall survival (OS) was analyzed using the Kaplan-Meier method, and a multivariate Cox proportional hazards model was performed to identify the independent prognostic factor. Anemic patients had a poorer OS compared with nonanemic patients after resection for tumor-nodes-metastasis (TNM) stage III tumors (5-year OS rate: 32...
January 17, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29341194/generation-of-red-drum-sciaenops-ocellatus-hematology-reference-intervals-with-a-focus-on-identified-outliers
#3
Kendal E Harr, Kristina Deak, Steven A Murawski, Drury R Reavill, Ryan A Takeshita
BACKGROUND: The Deepwater Horizon (DWH) oil spill in 2010 released millions of barrels of crude oil into the northern Gulf of Mexico, exposing numerous species of animals to the toxic components of oil. A comprehensive assessment of morbidity and mortality caused by DWH oil exposure was undertaken by the DWH Natural Resource Damage Trustees to characterize ecosystem damages. OBJECTIVES: This study aimed to characterize normal hematologic RIs in red drum fish with blood cell descriptions, and to demonstrate the importance of identifying and removing outliers when generating RI...
January 17, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29322365/iron-pots-for-the-prevention-and-treatment-of-anemia-in-preschoolers
#4
Francisco Plácido Nogueira Arcanjo, Débora Rodrigues Ribeiro Macêdo, Paulo Roberto Santos, Caio Plácido Costa Arcanjo
OBJECTIVE: To assess the effect of food cooked in iron pots for the prevention and treatment of iron deficiency anemia. METHODS: In this cluster randomized clinical trial, authors evaluated preschoolers aged 4-5 y for 16 wk. Children were cluster randomized to either eating from iron pots (Group A) or aluminum pots (Group B). Primary outcome variables were change in hemoglobin concentration and anemia prevalence. Two biochemical evaluations were performed, to determine Hb concentrations, before and after intervention...
January 11, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29319147/factors-associated-with-low-birthweight-in-term-pregnancies-a-matched-case-control-study-from-rural-pakistan
#5
Muhammad A Habib, Camille R Greenow, Shabina Ariff, Sajid Soofi, Abid Hussain, Qamar Junejo, Amjad Hussain, Fariha Shaheen, Kirsten I Black
Low birthweight (LBW) remains a significant public health problem in Pakistan and further understanding of factors associated with LBW is required. We conducted a hospital-based matched case control study to identify risk factors associated with LBW in a rural district of Pakistan. We found that illiteracy (AOR: 2.68; 95% CI: 1.59 - 4.38), nulliparity (AOR: 1.82; 95% CI: 1.26-2.44), having a previous miscarriage/abortion (AOR: 1.22; 95% CI: 1.06-2.35), having < 2 antenatal care (ANC) visits during last pregnancy (AOR: 2...
January 2, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29318944/prevalence-of-iron-deficiency-in-a-total-joint-surgery-population
#6
Jonathan H Waters, Peter Johnson, Mark H Yazer
BACKGROUND: Iron deficiency without anemia has been associated with decreases in functional work capacity and fatigue. The aim of this study was to determine the prevalence of iron deficiency without anemia in a preoperative cohort of orthopedic patients and to determine if iron deficiency is a condition which warrants inclusion into a prehabilitation program prior to surgery. METHODS: One hundred consecutive patients going through preoperative testing for total joint replacement were enrolled in the study...
January 10, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29316640/sub-chronic-toxicity-of-the-hydroethanolic-leaf-extract-of-telfairia-occidentalis-hook-f-cucurbitaceae-in-male-rats
#7
Abidemi J Akindele, Joy A Oladimeji-Salami, Ramon A Oyetola, Daniel D Osiagwu
Background: Due to its nutritional and medicinal values, the leaf of Telfairia occidentalis Hook f. (Cucurbitaceae) is consumed in different parts of Nigeria. Acute and sub-chronic toxicity of the hydroethanolic leaf extract of Telfairiaoccidentalis were investigated in this study. Methods: Sixty-four male rats were randomized into four different groups of 16 animals each and were separately administered 80, 400 and 2000 mg/kg T. occidentalis orally (p.o.) for 60 days. Animals were sacrificed and blood samples were collected for hematological and biochemical analyses...
January 6, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29312705/anemia-as-a-clinical-marker-of-stable-chronic-obstructive-pulmonary-disease-in-the-korean-obstructive-lung-disease-cohort
#8
Yeon-Mok Oh, Joo Hun Park, Eun-Kyung Kim, Sung Chul Hwang, Hyun Ji Kim, Dae Ryong Kang, Kwang Ha Yoo, Ji-Hyun Lee, Tae-Hyung Kim, Seong Yong Lim, Chin Kook Rhee, Hyoung Kyu Yoon, Sang Yeub Lee, Sang-Do Lee
Background: Anemia is a major co-morbidity in chronic obstructive pulmonary disease (COPD). However, the mechanism of development for anemia and the impact of anemia on the prognosis of COPD remain poorly understood. Therefore, this study attempted to evaluate the prognostic role of anemia on the clinical course of COPD and investigate the factors linked with the serum hemoglobin level in COPD. Methods: We analyzed 407 COPD patients enrolled in the Korean obstructive lung disease (KOLD) cohort at 16 hospitals in Korea recruited over 9 years...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29303050/is-there-a-difference-in-phenotype-between-males-and-females-with-non-transfusion-dependent-thalassemia-a-cross-sectional-evaluation
#9
Maria Marsella, Massimiliano Ammirabile, Tiziana Di Matola, Alessia Pepe, Silvia Costantini, Aldo Filosa, Paolo Ricchi
OBJECTIVES: Non-transfusion-dependent thalassemia includes a variety of phenotypes and genotypes that rarely require regular transfusions. However, these patients can experience a wide range of complications. The objective of this retrospective study was to verify whether there is a significant difference in non-transfusion-dependent thalassemia-related complications and treatment among males and females. METHODS: We performed a re-analysis of samples evaluated in a previously published cross-sectional study, regarding 96 non-transfusion-dependent thalassemia patients followed at the 'UOSD Malattie Rare del Globulo Rosso' Centre of the Cardarelli Hospital in Naples, Italy...
January 5, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29302541/anemia-in-pregnancy-and-its-associated-factors-among-primary-care-clients-in-sagamu-southwest-nigeria-a-facility-based-study
#10
Oluwafolahan Olugbenga Sholeye, Victor Jide Animasahun, Tessie O Shorunmu
Introduction: In Nigeria, anemia in pregnancy is one of the leading causes of poor pregnancy outcomes. This study, therefore, determined the prevalence of anemia and its associated factors, among pregnant primary care clients in Sagamu, Nigeria. Materials and Methods: A cross-sectional descriptive study was carried out among 400 pregnant, primary care clients in Sagamu, selected through multi-stage sampling. Data were collected with the aid of an interviewer-administered, semi-structured questionnaire, a stadiometer, measuring tape, and a hemoglobinometer...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29300737/an-evaluation-of-hemoglobin-measurement-tools-and-their-accuracy-and-reliability-when-screening-for-child-anemia-in-rwanda-a-randomized-study
#11
Megan Parker, Zhen Han, Elizabeth Abu-Haydar, Eric Matsiko, Damien Iyakaremye, Lisine Tuyisenge, Amalia Magaret, Alexandre Lyambabaje
Blood hemoglobin (Hb) is a common indicator for diagnosing anemia and is often determined through laboratory analysis of venous samples. One alternative to laboratory-based methods is the handheld HemoCue® Hb 201+ device, which requires a finger prick and wicking of blood into a pretreated cuvette for analysis. An alternative HemoCue® gravity method is being investigated for improved accuracy. Further, recent developments in noninvasive technologies could provide an accurate, rapid, safe, point-of-care option for hemoglobin estimation while addressing some limitations of current tools, but device performance must be assessed in low-resource settings...
2018: PloS One
https://www.readbyqxmd.com/read/29300196/mesenteric-oxygenation-changes-associated-with-necrotizing-enterocolitis-and-pneumoperitoneum-after-multiple-blood-transfusions-a-case-report
#12
Terri Marin, James E Moore
BACKGROUND: The multifactorial pathology and broad clinical presentation of necrotizing enterocolitis (NEC) development in premature infants make prediction of disease onset extremely challenging. Over the past decade, packed red blood cell (PRBC) transfusions have been temporally linked to the development of NEC in severely anemic preterm infants, although this issue is highly controversial. PURPOSE: In this case study, we describe events of an extremely low birth-weight infant who developed NEC complicated by pneumoperitoneum after receiving multiple PRBC transfusions...
January 3, 2018: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/29297831/whole-blood-transfusions-to-treat-severe-anemia-in-seven-cownose-rays-rhinoptera-bonasus-and-one-short-tail-stingray-dasyatis-brevicaudata
#13
Alexa J McDermott Delaune, Cara L Field, Tonya M Clauss
Blood transfusions can provide life-saving treatment to severely anemic animals. Due to limited availability and the difficulty of storing whole blood and blood products, such as fresh frozen plasma and packed red blood cells, exotic animals often receive fresh whole blood transfusions. Little is known about elasmobranch blood types and transfusions. Conspecific cross-matches within several different elasmobranch species were negative, indicating that in an emergency situation a single whole blood transfusion may be possible without causing a transfusion reaction...
December 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29296951/t-cell-assays-confirm-immunogenicity-of-tungsten-induced-erythropoietin-aggregates-associated-with-pure-red-cell-aplasia
#14
Tina Rubic-Schneider, Masataka Kuwana, Brigitte Christen, Manuela Aßenmacher, Otmar Hainzl, Frank Zimmermann, Robert Fischer, Vera Koppenburg, Salah-Dine Chibout, Timothy M Wright, Andreas Seidl, Michael Kammüller
Immunogenicity of biotherapeutics and the elicitation of anti-drug antibodies are a key concern for their efficacy, pharmacokinetics, and safety. A particularly severe consequence of immunogenicity of a biotherapeutic is the rare development of antibody-mediated pure red cell aplasia (PRCA) in anemic patients treated with aggregated forms of recombinant human erythropoietin (rhEPO). Here, we investigated in vitro T-cell responses to experimentally heat-induced rhEPO aggregates, and to tungsten-induced rhEPO aggregates in clinical lots associated with rhEPO-neutralizing antibodies and PRCA...
February 14, 2017: Blood Advances
https://www.readbyqxmd.com/read/29296795/erythropoiesis-stimulating-agents-in-elderly-patients-with-anemia-response-and-cardiovascular-outcomes
#15
Zachary Gowanlock, Swetha Sriram, Alison Martin, Anargyros Xenocostas, Alejandro Lazo-Langner
A specific cause of anemia cannot be identified in many elderly patients. Erythropoiesis-stimulating agents (ESAs) may play a role in treating these patients with anemia of unknown etiology (AUE). This study examines hemoglobin and cardiovascular outcomes among elderly anemic patients treated with ESAs. We conducted a retrospective cohort study that included all anemic patients older than age 60 years who had erythropoietin (EPO) measured between 2005 and 2013 at a single center. Three independent reviewers used defined criteria to assign each patient's anemia to 1 of 4 groups: chronic kidney disease (CKD), myelodysplastic syndrome, AUE, or other etiology...
August 22, 2017: Blood Advances
https://www.readbyqxmd.com/read/29290951/characteristics-and-comparison-between-diabetes-mellitus-and-non-diabetes-mellitus-among-chronic-kidney-disease-patients-a-cross-sectional-study-of-the-chinese-cohort-study-of-chronic-kidney-disease-c-stride
#16
Jun-Jun Zhang, Liu Yang, Jun-Wen Huang, Yu-Jie Liu, Jin-Wei Wang, Lu-Xia Zhang, Ming-Hui Zhao, Zhang-Suo Liu
Although the prevalence of chronic kidney disease (CKD) and diabetes mellitus (DM) is increasing globally, information on Chinese CKD patients with DM is lacking. A total of 3499 pre-dialysis CKD patients from across China were enrolled in the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE) between November 2011 and April 2016. We divided the C-STRIDE patients into CKD with DM and CKD without DM groups and compared their clinical, demographic, and laboratory data in this cross-sectional study. CKD patients with DM were older, had a higher male-to-female ratio, and had more complications than CKD patients without DM...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29289948/association-of-anemia-with-outcomes-in-patients-undergoing-percutaneous-peripheral-vascular-intervention-insights-from-the-blue-cross-blue-shield-of-michigan-cardiovascular-consortium-bmc2-vic
#17
Nikhil V Ambulgekar, Scott F Grey, Howard S Rosman, Hussein Othman, Thomas P Davis, Timothy J Nypaver, Theodore Schreiber, Hiroshi Yamasaki, Thomas A Lalonde, Peter K Henke, Hitinder S Gurm, Rajendra H Mehta, P Michael Grossman
OBJECTIVES: To evaluate the clinical features and outcomes of patients with anemia undergoing percutaneous peripheral vascular intervention (PVI) in a contemporary registry. METHODS: We evaluated the differences in the clinical features and outcomes of patients with and without anemia undergoing PVI in the Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2 VIC) registry. Anemia was defined using World Health Organization criteria. RESULTS: Baseline anemia was present in 42...
January 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29284032/prevalence-of-anemia-and-associated-factors-among-school-children-in-gondar-town-public-primary-schools-northwest-ethiopia-a-school-based-cross-sectional-study
#18
Zegeye Getaneh, Bamlaku Enawgaw, Getabalew Engidaye, Masresha Seyoum, Muruts Berhane, Zegeye Abebe, Fikir Asrie, Mulugeta Melku
BACKGROUND: Anemia is a global public health problem affecting 305 million school children (SC) worldwide. It has deleterious effects in SC, including lower school achievement due to impaired cognitive development and physical growth, fatigue and poor attention span, and increased morbidity because of reduced resistance to infection. Hence, the aim of this study was to assess the prevalence and associated factors of anemia among SC attending public primary schools in Gondar town, northwest Ethiopia...
2017: PloS One
https://www.readbyqxmd.com/read/29280914/anemia-and-coronary-artery-disease-pathophysiology-prognosis-and-treatment
#19
Jennifer A Rymer, Sunil V Rao
The mechanisms, pathophysiology, and treatment of anemia in coronary artery disease (CAD) are complex. The hemodynamic changes found in the acute anemic state may contribute to progressive arterial wall and left ventricular hypertrophy if the anemic state persists chronically. We will examine the evidence for anemia as an independent risk factor for CAD events and cardiovascular mortality after percutaneous coronary intervention. We will also investigate the thresholds for appropriate blood transfusion in patients with CAD, as well as the cardiovascular outcomes associated with the utilization of a liberal versus conservative blood transfusion strategy...
December 26, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29278742/evaluation-of-the-suitability-of-a-sprague-dawley-rat-model-to-assess-intravenous-iron-preparations
#20
Kimberley Span, Ebel H E Pieters, Vera Brinks, Wim E Hennink, Huub Schellekens
The aim of the study was to examine the reproducibility of a rat model to assess the preclinical similarity in safety profiles and tissue accumulation of iron products. Accordingly, the effect of several doses of intravenously administered Venofer® and of Ferrlecit® on blood parameters, and on kidney and particularly liver toxicity were examined in non-anemic Sprague Dawley rats. The different analysis showed neither a clear treatment nor a dose effect after multiple injections. The parameters measured in this rat strain showed some iron induced adverse effects, but these could not be correlated to treatment specific differences...
December 23, 2017: Journal of Pharmacological and Toxicological Methods
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