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https://www.readbyqxmd.com/read/28901512/gambogic-acid-suppresses-inflammation-in-rheumatoid-arthritis-rats-via-pi3k-akt-mtor-signaling-pathway
#1
Xiaodan Wu, Li Long, Jian Liu, Jin Zhang, Tong Wu, Xixi Chen, Bing Zhou, Ting-Zhuo Lv
Gamboge is the dried resin secreted by the Garcinia maingayi gambogic tree and is a substance that may be used to treat a variety of diseases, exhibits anti‑tumor and detoxification effects and prevents bleeding. The primary active constituent is gambogic acid. The present study aimed to investigate the anti‑inflammatory effects of gambogic acid in rheumatoid arthritis (RA) rats and to elucidate the mechanisms by which these effects occur. The swelling degree, the clinical arthritic scoring and pain threshold measurements were used to evaluate the effects of gambogic acid on RA...
September 11, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28891302/gastrocnemius-contracture-in-patients-with-rheumatoid-arthritis
#2
James R Jastifer, Adam Green
BACKGROUND: Rheumatoid arthritis is a chronic disease affecting multiple joints of the body. More than 90% of patients affected by rheumatoid arthritis develop foot or ankle pain over the course of their disease. The purpose of the current study was to report ankle dorsiflexion in rheumatoid arthritis patients as well as a control group utilizing a validated measurement instrument. METHODS: Using a previously validated device, 70 patients presenting with rheumatoid arthritis and 70 controls were measured for ankle range motion and isolated gastrocnemius contractures...
September 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28872725/dorsal-root-ganglion-field-stimulation-prevents-inflammation-and-joint-damage-in-a-rat-model-of-rheumatoid-arthritis
#3
Bin Pan, Zhiyong Zhang, Dongman Chao, Quinn H Hogan
OBJECTIVES: Electrical stimulation of the dorsal root ganglion (DRG), referred to here as ganglionic field stimulation (GFS), is effective in reducing clinical pain, probably by interrupting transmission of afferent impulse trains on sensory neurons as they pass through the DRG. We therefore tested whether efferent impulse trains conveyed by sensory neurons, which contribute to neurogenic inflammation, may also be interrupted by GFS. MATERIALS AND METHODS: Collagen-induced arthritis, a model of clinical rheumatoid arthritis, was initiated in rats concurrently with the insertion of an electrode for GFS at the fourth lumbar DRG...
September 5, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28867861/effect-of-integrative-naturopathy-and-yoga-in-a-patient-with-rheumatoid-arthritis-associated-with-type-2-diabetes-and-hypertension
#4
A Mooventhan, Geetha B Shetty
A 54-year old married woman was diagnosed with rheumatoid arthritis in 2002, essential hypertension in 2008, type-2 diabetes in 2011 and gangrene over 2(nd) toe of right foot. She underwent conventional management in private hospitals. Her symptoms, began with moderate to severe pain associated with swelling, stiffness (more in the morning) in multiple joints especially over small joints. In July-2014 she visited our college hospital with the complaints of pain, mild swelling and stiffness over multiple joints associated with poor quality of sleep (QOS) and quality of life (QOL)...
January 2017: Ancient Science of Life
https://www.readbyqxmd.com/read/28867061/the-evolution-of-arthritis-treatment-in-the-foot-and-ankle-a-change-in-the-gold-standard
#5
EDITORIAL
Alan Ng
No abstract text is available yet for this article.
October 2017: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/28865575/single-step-arthroscopic-repair-with-cell-free-polymer-based-scaffold-in-osteochondral-lesions-of-the-talus-clinical-and-radiological-results
#6
Ulunay Kanatlı, Ali Eren, Toygun Kağan Eren, Abdurrahman Vural, Dilan Ece Geylan, Ali Yusuf Öner
PURPOSE: To report the clinical and radiological results of patients with talar osteochondral lesions who were treated by microfracture and cell-free scaffold implantation in a single-step arthroscopic surgery. METHODS: Forty patients, treated with a single-step arthroscopic surgery, were evaluated in this single-center-based retrospective study. Patients with degenerative arthritis (n = 1), history of ankle fracture (n = 1), kissing lesions (n = 1), lower extremity deformity (n = 1), and lesions <1...
September 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28854762/efficacy-of-open-debridement-and-polyethylene-exchange-in-strictly-selected-patients-with-infection-after-total-knee-arthroplasty
#7
Whee Sung Son, Oog-Jin Shon, Dong-Chul Lee, Sang-Jin Park, Han Seok Yang
Purpose: To assess the efficacy of open debridement and polyethylene exchange (ODPE) combined with proper antibiotic therapy in strictly selected patients with infection after total knee arthroplasty (TKA) and analyze factors associated with treatment failure. Materials and Methods: From January 2010 to January 2014, 25 cases that underwent ODPE under the diagnosis of infection within four weeks after TKA or acute hematogenous infection within five days of symptom onset were reviewed in this study...
September 1, 2017: Knee Surgery & related Research
https://www.readbyqxmd.com/read/28841865/comparison-of-outcomes-according-to-fixation-technique-following-the-modified-ludloff-osteotomy-for-hallux-valgus-in-patients-with-rheumatoid-arthritis
#8
Young-Hoon Jo, Ki-Chul Park, Young-Sik Song, Il-Hoon Sung
BACKGROUND: Clinical and radiological outcomes including fixation stability of osteotomy site were compared in rheumatoid arthritis (RA) patients who underwent modified Ludloff osteotomy to correct hallux valgus with osteotomy site fixation using two screws versus those who underwent additional fixation using a plate. METHODS: The fixation technique performed with two screws was used to fix the osteotomy sites following modified Ludloff osteotomy in 15 patients (15 feet, Group S), while the augmented plate fixation technique was used in 14 patients (16 feet, Group P)...
August 25, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28840151/epidemiology-of-navicular-injury-at-the-nfl-combine-and-their-impact-on-an-athlete-s-prospective-nfl-career
#9
Bryan Vopat, Brendin R Beaulieu-Jones, Gregory Waryasz, Kevin J McHale, George Sanchez, Catherine A Logan, James M Whalen, Christopher W DiGiovanni, Matthew T Provencher
BACKGROUND: Navicular injuries can result in persistent pain, posttraumatic osteoarthritis, and diminished performance and function. PURPOSE: To determine the epidemiology of navicular fracture in players participating in the National Football League (NFL) Scouting Combine and evaluate the impact of a navicular injury on the NFL draft position and NFL game play compared with matched controls. STUDY DESIGN: Cohort study; Level of evidence, 3...
August 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28836966/impact-of-midfoot-and-hindfoot-involvement-on-functional-disability-in-korean-patients-with-rheumatoid-arthritis
#10
Hye-Jin Jeong, Il Woong Sohn, Dam Kim, Soo-Kyung Cho, Si-Bog Park, Il-Hoon Sung, Yoon-Kyoung Sung
BACKGROUND: Foot involvement in rheumatoid arthritis (RA) patients has been reported to severely affect functional capacity and quality of life. We aimed to determine the impact of midfoot and hindfoot involvement on functional disability in Korean patients with RA. METHODS: We evaluated the RA involvement and deformity of three regions of the foot (forefoot, midfoot and hindfoot) and ankle using conventional radiography in Korean patients with RA. We compared the clinical features between RA patients with and without foot or ankle involvement...
August 24, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28836449/adjacent-joint-kinematics-after-ankle-arthrodesis-during-cadaveric-gait-simulation
#11
Daniel R Sturnick, Constantine A Demetracopoulos, Scott J Ellis, Robin M Queen, Jayme C B Kolstov, Jonathan T Deland, Josh R Baxter
BACKGROUND: Arthrodesis is an effective and reliable treatment for end-stage ankle arthritis; however, many patients develop ipsilateral adjacent joint arthritis following surgery. The mechanism that drives adjacent joint arthritis remains uncertain. Cadaveric simulation permits direct investigation of the effects of both arthrodesis and movement strategy on adjacent joints during simulated walking. The objective of this study was to identify the isolated effect of ankle arthrodesis on adjacent joint kinematics during simulated walking...
August 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28812410/good-outcome-scores-and-high-satisfaction-rate-after-primary-total-ankle-replacement
#12
Ilka Kamrad, Åke Carlsson, Anders Henricson, Håkan Magnusson, Magnus K Karlsson, Björn E Rosengren
Background and purpose - Total ankle replacement (TAR) is gaining popularity for treatment of end-stage ankle arthritis. Large patient-centered outcome studies are, however, few. Here, we report data from the Swedish Ankle Registry. Patients and methods - We examined outcomes after primary TAR in patients from the Swedish Ankle Registry using PROMs (Patient Reported Outcome Measures; generic: EQ-5D and SF-36, region specific: SEFAS (Self-Reported Foot and Ankle Score), and a question on satisfaction). We included 241 patients registered with primary TAR between 2008 and 2016 and who completed PROMs preoperatively and postoperatively up to 24 months...
August 16, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28809629/-talar-neck-fractures-treated-using-percutaneous-screw-fixation
#13
R Veselý, M Kelbl, J Kacián, V Hulka, J Kočiš, R Kunovský
PURPOSE OF THE STUDY Closed reduction and percutaneous fixation of nondisplaced talar neck fractures have been applied by some authors. The aim of this paper is to assess the results and complications of this minimally invasive technique. MATERIAL AND METHODS In the period from 2009 to 2014, twenty-one patients with a talar neck fracture were observed after closed reduction and percutaneous screw fixation in the Traumatological Hospital in Brno. The mean age of the patients was 38 years (range 18-56 years)...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28779809/is-this-my-ankle-or-my-foot
#14
REVIEW
William Hodges Davis
Understanding of the complexities of the adult acquired pathologic flatfoot has undergone serious evolution in the past 30 years to an understanding of the subtleties of what causes the different presentations and drives successful treatment. As the treatment of ankle arthritis evolves from fusion to ankle replacement, the need for answers for the difficult patient with valgus degenerative ankle disease begs a look at what causes this form of flatfoot. This article poses the question, is there a subset of patients with "flatfoot" that has little to do with the foot and is all about the ankle?...
September 2017: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/28779807/calcaneal-osteotomies-pearls-and-pitfalls
#15
REVIEW
Stephen Greenfield, Bruce Cohen
Adult acquired flatfoot deformity is a debilitating condition typically affecting middle-aged patients. The multiple components include hindfoot valgus, first ray elevation, medial soft tissue compromise, and forefoot abduction. As the foot becomes unbalanced, the deformity progresses with repetitive loading and time. Untreated patients often need significant reconstructions or extensive arthrodesis after arthritis and joint contractures present. Medializing calcaneal osteotomy is the workhorse operation for correction of hindfoot valgus, reliably correcting deformity with a relatively low complication risk...
September 2017: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/28779803/deltoid-ligament-repair-in-flatfoot-deformity
#16
REVIEW
Ezekiel Oburu, Mark S Myerson
Deltoid ligament reconstruction allows for joint preservation of the ankle in the setting of patients a triple arthrodesis due to a flat foot deformity. Although the increased forces that may occur in the ankle joint after a triple arthrodesis cannot be eliminated, reconstruction of the ligament will delay and may prevent the onset arthritis, allowing the patient to maintain mobility of the ankle joint. The anatomy, surgery, and risks and benefits are discussed.
September 2017: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/28767173/prevalence-presentation-and-treatment-of-lower-limb-pathologies-in-juvenile-idiopathic-arthritis-a-narrative-review
#17
REVIEW
Antoni Fellas, Fiona Hawke, Derek Santos, Andrea Coda
Juvenile idiopathic arthritis is a chronic, autoimmune, inflammatory joint disease. It is the most common arthritis in children and adolescents. This paper reviews the presentation and treatment of lower limb pathologies in juvenile idiopathic arthritis from an allied health perspective. Common lower limb pathologies include: synovitis causing swelling, tenderness and pain; persistent inflammation leading to flexion contractures; limb length discrepancies; muscle atrophy; enthesopathies such as plantar fasciitis and Achilles tendonitis; and tenosynovitis...
August 2, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28761771/lateral-subtalar-dislocation-with-tarsometatarsal-dislocation-a-case-report-of-a-rare-injury
#18
Samik Banerjee, Mostafa M Abousayed, Douglas J Vanderbrook, Kaushik Bagchi
Dislocation of the fourth and fifth tarsometatarsal joints in conjunction with lateral subtalar dislocation is a rare occurrence. Little is known about the mechanism of injury, the appropriate treatment for this condition, and its ultimate prognosis. In this report, we describe this atypical presentation in a middle aged, otherwise healthy male who sustained a trivial twisting injury to the ankle when he slipped and fell on ice. Open reduction and K-wire fixation were necessary to affix the lateral tarsometatarsal and talonavicular joints...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28753225/review-of-dynamic-contrast-enhanced-mri-technical-aspects-and-applications-in-the-musculoskeletal-system
#19
REVIEW
Parvinder Sujlana, Jan Skrok, Laura M Fayad
Although postcontrast imaging has been used for many years in musculoskeletal imaging, dynamic contrast enhanced (DCE) MRI is not routinely used in many centers around the world. Unlike conventional contrast-enhanced sequences, DCE-MRI allows the evaluation of the temporal pattern of enhancement in the musculoskeletal system, perhaps best known for its use in oncologic applications (such as differentiating benign from malignant tumors, evaluating for treatment response after neoadjuvant chemotherapy, and differentiating postsurgical changes from residual tumor)...
July 28, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28752968/-effects-of-triptolide-on-the-autophagy-in-synovial-spleen-and-thymus-of-rats-with-adjuvant-arthritis
#20
Lei Wan, Jian Liu, Chuan-Bing Huang, Xiao-Jun Zhang, Ya-Li Wang, Ping-Heng Zhang, Yue Sun, Lei Liu
OBJECTIVE: To determine the effect of triptolide (TP) on the expression of ATG /LC3-Ⅱ Beclin1 in synovial, spleen, and thymusof rats with adjuvant arthritis (AA). METHODS: Rats were divided for four groups: normal control (NC), model control (MC), leflunomide (LEF) treatment, and triptolide (TP)treatment, with 12 rats in each group.The AA model was established through Freund's complete adjuvant (0.1 mL each) injection into the right foot plantar skin to introduce inflammation and 10 days of tail root injection of 0...
July 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
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