keyword
https://read.qxmd.com/read/36111212/nontherapeutic-risk-factors-of-different-grouped-stage-iiic-breast-cancer-patients-mortality-a-study-of-the-us-surveillance-epidemiology-and-end-results-database
#21
JOURNAL ARTICLE
Yue Qiu, Hongye Chen, Yongjing Dai, Baoshi Bao, Lin Tian, Yuhui Chen
OBJECTIVES: Stage IIIC breast cancer, as a local advanced breast cancer, has a poor prognosis compared with that of early breast cancer. We further investigated the risk factors of mortality in stage IIIC primary breast cancer patients and their predictive value. METHODS: We extracted data from the US Surveillance, Epidemiology, and End Results (SEER) database of female patients with stage IIIC primary breast cancer ( n  = 1673) from January 2011 to December 2015...
2022: Breast Journal
https://read.qxmd.com/read/36048111/young-adults-beliefs-about-modern-oral-nicotine-products-implications-for-uptake-in-nonvapers-dual-use-with-e-cigarettes-and-use-to-reduce-quit-vaping
#22
JOURNAL ARTICLE
Dae-Hee Han, Junhan Cho, Alyssa F Harlow, Alayna P Tackett, Erin A Vogel, Melissa Wong, Jessica L Barrington-Trimis, Caryn Lerman, Jennifer B Unger, Adam M Leventhal
Modern oral nicotine products (ONPs; nontherapeutic nicotine pouches, gums, lozenges, and gummies) may be perceived in ways that could promote uptake in nonvapers, dual use with e-cigarettes, or use to quit vaping. In this cross-sectional digital remote survey of 1,460 respondents aged 21-24 from Southern California, we examined beliefs about ONPs among past-30-day e-cigarette nonusers, users unmotivated to quit vaping, and users motivated to quit vaping. Positive beliefs about ONPs were reported by 31.8% of the overall sample and higher in past-30-day e-cigarette users (with or without quit motivation) than nonusers...
September 1, 2022: Experimental and Clinical Psychopharmacology
https://read.qxmd.com/read/35934731/adolescent-use-of-flavored-non-tobacco-oral-nicotine-products
#23
JOURNAL ARTICLE
Alyssa F Harlow, Erin A Vogel, Alayna P Tackett, Junhan Cho, Dae-Hee Han, Melissa Wong, Myles G Cockburn, Steve Y Sussman, Jennifer B Unger, Adam M Leventhal, Jessica L Barrington-Trimis
BACKGROUND AND OBJECTIVES: Flavored non-tobacco oral nicotine products (eg, nicotine pouches and nontherapeutic nicotine gum, lozenges, tablets, gummies), are increasingly marketed in the United States. Prevalence of non-tobacco oral nicotine product use among adolescents is unknown. METHODS: We calculated prevalence of ever and past 6-month use of nicotine pouches, other non-tobacco oral nicotine products (ie, gum, lozenges, tablets, and/or gummies), e-cigarettes, cigarettes, hookah or waterpipe, cigars, cigarillos, and snus among high school students in Southern California between September and December 2021...
September 1, 2022: Pediatrics
https://read.qxmd.com/read/35905150/small-animal-general-practitioners-discuss-nutrition-infrequently-despite-assertion-of-indication-citing-barriers
#24
JOURNAL ARTICLE
Elizabeth E Alvarez, Kelly K Schultz, Amanda M Floerchinger, Jennifer L Hull
OBJECTIVE: To determine what perceived factors prevent small animal general practitioners from discussing pet nutrition with clients during healthy and sick pet appointments. SAMPLE: 403 veterinarians in small animal general practice. PROCEDURES: An online survey was used to gather veterinarians' opinions on perceived barriers, knowledge levels, and confidence regarding pet nutrition discussions. RESULTS: Reported barriers to discussing nutrition during healthy pet appointments included client resistance to changing brand (149/359), time constraints (146/359), misinformation online (138/359), and difficulty keeping up with products (132/359)...
July 28, 2022: Journal of the American Veterinary Medical Association
https://read.qxmd.com/read/35857320/cannabinoid-content-and-label-accuracy-of-hemp-derived-topical-products-available-online-and-at-national-retail-stores
#25
JOURNAL ARTICLE
Tory R Spindle, Dennis J Sholler, Edward J Cone, Timothy P Murphy, Mahmoud ElSohly, Ruth E Winecker, Ronald R Flegel, Marcel O Bonn-Miller, Ryan Vandrey
Importance: Products containing cannabinoids such as cannabidiol (CBD) have proliferated since 2018, when the Agriculture Improvement Act removed hemp (ie, cannabis containing <0.3% Δ9-tetrahydrocannabinol [THC]) from the US controlled substances list. Topical cannabinoid products can be purchased nationwide at retail stores and over the internet, yet research on these products is scarce. Objective: To evaluate the cannabinoid content (ie, CBD and THC) and label accuracy of topical cannabinoid products and to quantify their therapeutic and nontherapeutic claims...
July 1, 2022: JAMA Network Open
https://read.qxmd.com/read/35788578/prospective-evaluation-of-the-selective-nonoperative-management-of-abdominal-stab-wounds-when-is-it-safe-to-discharge
#26
JOURNAL ARTICLE
Natthida Owattanapanich, Camilla Cremonini, Morgan A Schellenberg, Kazuhide Matsushima, Meghan R Lewis, Lydia Lam, Matthew J Martin, Kenji Inaba
BACKGROUND: The optimal observation time required to exclude hollow viscus injury in patients undergoing selective nonoperative management (SNOM) for abdominal stab wounds (SWs) remains unclear. The aim of this study was to determine the safe period of observation required before discharge. METHODS: In this prospective observational study, all patients who sustained an abdominal SW were screened for study inclusion (July 2018 to May 2021). The primary study outcome was time to SNOM failure, defined as the need for surgical intervention after an initial period of observation...
November 1, 2022: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/35702830/diagnosing-prescription-opioid-use-disorder-in-patients-using-prescribed-opioids-for-chronic-pain
#27
JOURNAL ARTICLE
Deborah S Hasin, Dvora Shmulewitz, Malka Stohl, Eliana Greenstein, Efrat Aharonovich, Kenneth R Petronis, Michael Von Korff, Samyadev Datta, Nomita Sonty, Stephen Ross, Charles Inturrisi, Michael L Weinberger, Jennifer Scodes, Melanie M Wall
OBJECTIVE: The diagnostic criteria for opioid use disorder, originally developed for heroin, did not anticipate the surge in prescription opioid use and the resulting complexities in diagnosing prescription opioid use disorder (POUD), including differentiation of pain relief (therapeutic intent) from more common drug use motives, such as to get high or to cope with negative affect. The authors examined the validity of the Psychiatric Research Interview for Substance and Mental Disorders, DSM-5 opioid version, an instrument designed to make this differentiation...
October 2022: American Journal of Psychiatry
https://read.qxmd.com/read/35686001/antineoplastic-activity-of-biogenic-silver-and-gold-nanoparticles-to-combat-leukemia-beginning-a-new-era-in-cancer-theragnostic
#28
JOURNAL ARTICLE
Ebrahim Mostafavi, Atefeh Zarepour, Hamed Barabadi, Ali Zarrabi, Linh B Truong, David Medina-Cruz
The American Cancer Society estimated around 61,090 new cases of leukemia were diagnosed, and around 23,660 people died from this disease in the United States alone in 2021. Due to its burden on society, there is an unmet need to explore innovative approaches to overcome leukemia. Among different strategies that have been explored, nanotechnology appears to be a promising and effective approach for therapeutics. Specifically, biogenic silver and gold nanoparticles (NPs) have attracted significant attention for their antineoplastic activity toward leukemia cancer cells due to their unique physicochemical properties...
June 2022: Biotechnology Reports
https://read.qxmd.com/read/35639672/the-effect-of-a-therapeutic-smartphone-application-on-suicidal-ideation-in-young-adults-findings-from-a-randomized-controlled-trial-in-australia
#29
JOURNAL ARTICLE
Michelle Torok, Jin Han, Lauren McGillivray, Quincy Wong, Aliza Werner-Seidler, Bridianne O'Dea, Alison Calear, Helen Christensen
BACKGROUND: Suicidal ideation is a major risk for a suicide attempt in younger people, such that reducing severity of ideation is an important target for suicide prevention. Smartphone applications present a new opportunity for managing ideation in young adults; however, confirmatory evidence for efficacy from randomized trials is lacking. The objective of this study was to assess whether a therapeutic smartphone application ("LifeBuoy") was superior to an attention-matched control application at reducing the severity of suicidal ideation...
May 2022: PLoS Medicine
https://read.qxmd.com/read/35628286/antitumoral-activity-of-a-cdk9-protac-compound-in-her2-positive-breast-cancer
#30
JOURNAL ARTICLE
María Del Mar Noblejas-López, Lucía Gandullo-Sánchez, Eva M Galán-Moya, Raquel López-Rosa, David Tébar-García, Cristina Nieto-Jiménez, Mónica Gómez-Juárez, Miguel Burgos, Atanasio Pandiella, Alberto Ocaña
Cyclin-dependent kinases (CDKs) are a broad family of proteins involved in the cell cycle and transcriptional regulation. In this article, we explore the antitumoral activity of a novel proteolysis-targeting chimera (PROTAC) compound against CDK9. Breast cancer cell lines from different subtypes were used. Transcriptomic mapping of CDKs in breast cancer demonstrated that the expression of CDK9 predicted a detrimental outcome in basal-like tumors (HR = 1.51, CI = 1.08-2.11, p = 0.015) and, particularly, in the luminal B subtype with HER2+ expression (HR = 1...
May 13, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35620541/covid-19-mortality-and-its-predictors-in-the-elderly-a-systematic-review
#31
REVIEW
Omid Dadras, SeyedAhmad SeyedAlinaghi, Amirali Karimi, Ahmadreza Shamsabadi, Kowsar Qaderi, Maryam Ramezani, Seyed Peyman Mirghaderi, Sara Mahdiabadi, Farzin Vahedi, Solmaz Saeidi, Alireza Shojaei, Mohammad Mehrtak, Shiva A Azar, Esmaeil Mehraeen, Fabrício A Voltarelli
BACKGROUND AND AIMS: Older people have higher rates of comorbidities and may experience more severe inflammatory responses; therefore, are at higher risk of death. Herein, we aimed to systematically review the mortality in coronavirus disease 2019 (COVID-19) patients and its predictors in this age group. METHODS: We searched PubMed, Web of Science, and Science Direct using relevant keywords. Retrieved records underwent a two-step screening process consisting of title/abstract and full-text screenings to identify the eligible studies...
May 2022: Health Science Reports
https://read.qxmd.com/read/35579542/-honors-granted-by-the-german-society-for-child-and-adolescent-psychiatry-psychosomatics-and-psychotherapy-dgkjp-and-its-predecessors
#32
JOURNAL ARTICLE
Klaus Schepker, Jörg M Fegert
Honors granted by the German Society for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy (DGKJP) and its predecessors Abstract. Abstracts: This research on the "honors" granted by the German Society for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy (DGKJP) investigated all persons honored by the society from 1950 (following the postwar reestablishment of the society) up through 1990 (German reunification). We explored the adequacy of the honors regarding the professional ethics of the honorees during the NS-regime...
May 17, 2022: Zeitschrift Für Kinder- und Jugendpsychiatrie und Psychotherapie
https://read.qxmd.com/read/35579357/how-can-the-rate-of-nontherapeutic-thymectomy-be-reduced
#33
JOURNAL ARTICLE
Shuai Wang, Yongqiang Ao, Jiahao Jiang, Miao Lin, Gang Chen, Junzhen Liu, Shihai Zhao, Jian Gao, Yi Zhang, Jianyong Ding, Lijie Tan
OBJECTIVES: To determine the prevalence of nontherapeutic thymectomy and define a clinical standard to reduce it. METHODS: From 2016 to 2020, consecutive patients who underwent thymectomy were retrospective reviewed. Univariable and multivariable analyses were used to identify the correlation factors of nontherapeutic thymectomy. A receiver operating characteristic (ROC) curve was analyzed to assess the cutoff threshold of factors correlated with nontherapeutic thymectomy...
May 17, 2022: Interactive Cardiovascular and Thoracic Surgery
https://read.qxmd.com/read/35482017/an-updated-assessment-of-43-110-patients-enrolled-in-the-childhood-cancer-research-network-a-children-s-oncology-group-report
#34
JOURNAL ARTICLE
Austin L Brown, Pagna Sok, Michael E Scheurer, Karen R Rabin, Erin L Marcotte, Douglas S Hawkins, Logan G Spector, Philip J Lupo
BACKGROUND: The Childhood Cancer Research Network (CCRN) was established by the Children's Oncology Group (COG) as a resource for epidemiologic studies of childhood cancer. The objective of this study was to evaluate the representativeness of CCRN and identify factors associated with enrollment. METHOD: The number of US childhood patients with cancer diagnosed <20 years of age enrolled in CCRN (2008-2015) was compared to expected counts, calculated from Surveillance, Epidemiology, and End Results incidence rates and US Census population estimates...
July 15, 2022: Cancer
https://read.qxmd.com/read/35404020/willingness-to-participate-in-various-nontherapeutic-cancer-research-activities-among-urban-and-rural-african-american-and-latinx-healthy-volunteers
#35
JOURNAL ARTICLE
Isabel C Scarinci, Barbara Hansen, B Lee Green, Stephen O Sodeke, Eboni G Price-Haywood, Young-Il Kim
PURPOSE: Inclusion of racial/ethnic minorities in cancer research can reduce disparities in health outcomes; however, data regarding barriers and motivators to participation are sparse. This study assessed African American (AA) and Latinx healthy volunteers' perspectives regarding willingness to participate in noninvasive and invasive research activities. METHODS: Using a 38-item questionnaire adapted from the Tuskegee Legacy Project Questionnaire, we assessed willingness to participate in 12 research activities, offering 27 possible barriers and 14 motivators...
August 2022: Cancer Causes & Control: CCC
https://read.qxmd.com/read/35341346/serial-ct-for-nonoperatively-managed-splenic-injuries
#36
JOURNAL ARTICLE
Saskya E Byerly, Michael D Jones, Emily K Lenart, Catherine P Seger, Dina M Filiberto, Richard H Lewis, Andrew J Kerwin, Louis J Magnotti
INTRODUCTION: The role of serial computed tomography (CT) in the nonoperative management of blunt splenic injuries (NOMSIs) remains unclear. The purpose of the study was to determine the utility of serial CT of Grade 2-5 NOMSI in the modern era. METHODS: Blunt splenic injuries were identified over a 3.5-year period, ending in 6/2020. Our institutional protocol for NOMSI mandates a repeat 24-hour CT for Grade 2-5 injuries. Patients age<18, Grade 1 injuries and patients that underwent intervention prior to repeat scan were excluded...
March 28, 2022: American Surgeon
https://read.qxmd.com/read/35324097/how-should-clinicians-determine-a-traumatized-patient-s-readiness-to-return-to-work
#37
JOURNAL ARTICLE
Tabitha E H Moses, Arash Javanbakht
A clinician's standard primary role is to treat and monitor their patients' health and to be their ally. Clinicians with obligations to patients and to organizations, however, must also assess patients for nontherapeutic purposes (eg, readiness to resume work). These 2 obligations can conflict, and, when they do, clinicians must balance their duties to patients and to society. We propose criteria clinicians should consider when determining a patient's readiness to return to work and offer recommendations for interpreting factors that influence this decision...
February 1, 2022: AMA Journal of Ethics
https://read.qxmd.com/read/35100440/using-the-merlin-assay-for-reducing-sentinel-lymph-node-biopsy-complications-in-melanoma-a-retrospective-cohort-study
#38
JOURNAL ARTICLE
Tina J Hieken, Mariana B Sadurní, Enrica Quattrocchi, Ajdin Kobic, Sindhuja Sominidi-Damodaran, Jvalini T Dwarkasing, Lisette Meerstein-Kessel, Alina G Bridges, Alexander Meves
BACKGROUND: The assessment of the sentinel lymph node is a cornerstone of melanoma staging. However, ~80% of sentinel lymph node biopsies (SLNB) are negative and nontherapeutic, and patients are unnecessarily exposed to surgery-related complications. Here, we gauged the potential of the Merlin assay to reduce SLNB-associated complications. The Merlin assay uses clinicopathologic variables and tumor gene expression profiling to identify low-risk patients who may forgo SLNB. METHODS: We utilized the Merlin test development cohort to determine SLNB complication rates for procedures performed between 2004 and 2018 at Mayo Clinic...
July 2022: International Journal of Dermatology
https://read.qxmd.com/read/35021163/opinion-article-the-acute-radiation-syndrome-need-for-updated-medical-guidelines
#39
JOURNAL ARTICLE
Leif Stenke, Christel Hedman, Marita Lagergren Lindberg, Karin Lindberg, Jack Valentin
The major immediate and severe medical consequences in man following exposure to high doses of ionizing radiation can be summarized within the concept of the acute radiation syndrome (ARS). In a dose-dependent fashion, a multitude of organ systems can be affected by such irradiation, presenting considerable medical challenges to treating physicians. Accidents or malevolent events leading to ARS can provoke devastating effects, but they occur at a low frequency and in a highly varying manner and magnitude. Thus, it is difficult to make precise medical predictions and planning, or to draw conclusive evidence from occurred events...
January 12, 2022: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://read.qxmd.com/read/35014211/combinational-application-of-metal-organic-frameworks-based-nanozyme-and-nucleic-acid-delivery-in-cancer-therapy
#40
REVIEW
Dongqi Ni, Jinhui Lin, Nuozi Zhang, Shilin Li, Yueguang Xue, Ziyao Wang, Qianglin Liu, Kai Liu, Hongjie Zhang, Yuliang Zhao, Chunying Chen, Ying Liu
The rapid development of nanotechnology has generated numerous ideas for cancer treatment, and a wide variety of relevant nanoparticle platforms have been reported. Metal-organic frameworks (MOFs) have been widely investigated as an anti-cancer drug delivery vehicle owing to their unique porous hybrid structure, biocompatibility, structural tunability, and multi-functionality. MOF materials with catalytic activity, known as nanozymes, have applications in photodynamic and chemodynamic therapy. Nucleic acids have also attracted increasing research attention owing to their programmability, ease of synthesis, and versatility...
January 10, 2022: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
keyword
keyword
78917
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.