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neisseria meningitidis

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https://www.readbyqxmd.com/read/29779947/intermittent-pili-mediated-forces-fluidize-neisseria-meningitidis-aggregates-promoting-vascular-colonization
#1
Daria Bonazzi, Valentina Lo Schiavo, Silke Machata, Ilyas Djafer-Cherif, Pierre Nivoit, Valeria Manriquez, Hirokazu Tanimoto, Julien Husson, Nelly Henry, Hugues Chaté, Raphael Voituriez, Guillaume Duménil
Neisseria meningitidis, a bacterium responsible for meningitis and septicemia, proliferates and eventually fills the lumen of blood capillaries with multicellular aggregates. The impact of this aggregation process and its specific properties are unknown. We first show that aggregative properties are necessary for efficient infection and study their underlying physical mechanisms. Micropipette aspiration and single-cell tracking unravel unique features of an atypical fluidized phase, with single-cell diffusion exceeding that of isolated cells...
May 15, 2018: Cell
https://www.readbyqxmd.com/read/29776398/primary-bacterial-ventriculitis-in-adults-an-emergent-diagnosis-challenge-report-of-a-meningoccal-case-and-review-of-the-literature
#2
Anaïs Lesourd, Nicolas Magne, Anaïs Soares, Caroline Lemaitre, Muhamed-Kheir Taha, Isabelle Gueit, Michel Wolff, François Caron
BACKGROUND: Defined by an infection of the ventricular system of the brain, ventriculitis is usually known as a health-care associated infection. In contrast, primary pyogenic ventriculitis complicating community-acquired meningitis is uncommon, and mainly described in infants. Only seven cases that have occured in adults have been found in the international literature. CASE PRESENTATION: We report here a new case due to Neisseria meningitidis occurring in an 85 year-old-man...
May 18, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29770081/increase-in-neisseria-meningitidis-serogroup-w-invasive-disease-in-canada-2009-2016
#3
Rsw Tsang, L Hoang, G J Tyrrell, G Horsman, P Van Caeseele, F Jamieson, B Lefebvre, D Haldane, R R Gad, G J German, G Zahariadis
No abstract text is available yet for this article.
July 6, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29767396/are-lactoferrin-receptors-in-gram-negative-bacteria-viable-vaccine-targets
#4
Clement Chan, Vahid F Andisi, Dixon Ng, Nick Ostan, Warren K Yunker, Anthony B Schryvers
A number of important Gram-negative pathogens that reside exclusively in the upper respiratory or genitourinary tract of their mammalian host rely on surface receptors that specifically bind host transferrin and lactoferrin as a source of iron for growth. The transferrin receptors have been targeted for vaccine development due to their critical role in acquiring iron during invasive infection and for survival on the mucosal surface. In this study, we focus on the lactoferrin receptors, determining their prevalence in pathogenic bacteria and comparing their prevalence in commensal Neisseria to other surface antigens targeted for vaccines; addressing the issue of a reservoir for vaccine escape and impact of vaccination on the microbiome...
May 16, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29764949/toward-an-improved-meningococcal-serogroup-b-assay
#5
Jan Poolman
Because of diverse sequences and differential expression of surface structures on individual invasive Neisseria meningitidis serogroup B (MenB) strains, predicting the efficacy of MenB vaccines using traditional human serum bactericidal assays (hSBA) is impractical. The meningococcal antigen surface expression (MEASURE) assay uses flow cytometry to quantitate the expression of factor H binding proteins (fHbp) contained in the bivalent rLP2086 MenB vaccine. To date, experience with MEASURE has been lacking, and in a long-awaited article, McNeil et al...
May 15, 2018: MBio
https://www.readbyqxmd.com/read/29764940/the-tetrameric-structure-of-sialic-acid-synthesizing-udp-glcnac-2-epimerase-from-acinetobacter-baumannii-a-comparative-study-with-human-gne
#6
Tzu-Ping Ko, Shu-Jung Lai, Tung-Ju Hsieh, Chia-Shin Yang, Yeh Chen
Sialic acid presentation on the cell surface by some pathogenic strains of bacteria allows their escape from the host immune system. It is one of the major virulence factors. Bacterial biosynthesis of sialic acids starts with the conversion of UDP-GlcNAc to UDP and ManNAc by a hydrolyzing 2-epimerase. Here we present the crystal structure of this enzyme, named NeuC, from Acinetobacter baumannii The protein folds into two Rossmann-like domains and forms dimers and tetramers as does the epimerase part of the bifunctional UDP-GlcNAc 2-epimerase / ManNAc kinase (GNE)...
May 15, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29757696/a-refugee-patient-with-meningococcal-meningitis-type-b
#7
Aslinur Ozkaya-Parlakay, Saliha Kanik-Yuksek, Belgin Gulhan, Hasan Tezer, Filiz Altay, Nuriye Unal-Sahin
Neisseria meningitidis infection constitutes still a major health problem with significant morbidity and mortality. In this report a 2 year old refugee Turkoman boy admitting with fever and vomitting diagnosed as meningococcal meningitis type B who was cured with intravenous ceftriaxone therapy was presented to emphasize importance of implementing new strategies for health care of refugees.
May 14, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29754466/temporal-trends-in-paediatric-bacterial-meningitis-in-a-tropical-australian-region-1992-2014
#8
Stephanie White, Hala Katf, Rob Baird, Joshua Francis
AIM: The epidemiology of community-acquired bacterial meningitis has changed following the introduction of routine immunisation against common causative organisms. Indigenous children living in the Northern Territory, Australia, have high rates of bacterial infections. This study describes changes in the epidemiology of childhood bacterial meningitis and the distribution of the burden of disease in the Top End. METHODS: A retrospective review of cases derived from hospital medical records and laboratory data was performed...
May 13, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29743304/molecular-characterization-of-invasive-isolates-of-neisseria-meningitidis-in-casablanca-morocco
#9
Aziza Razki, Eva Hong, Khalid Zerouali, Houria Belabbes, Khadija Aitmouss, Aude Terrade, Bahija Zaki, Ala-Eddine Deghmane, Naima Elmdaghri, Muhamed-Kheir Taha
Meningococcal epidemiology may change unpredictably and typing of isolates of Neisseria meningitidis is crucial for the surveillance of invasive meningococcal disease (IMD). Few data are available of the meningococcal epidemiology in countries of North Africa. We aimed to explore the invasive meningococcal isolates from the Casablanca region in Morocco. We used whole genome sequencing (WGS) to characterize 105 isolates from this region during the period 2011-2016. Our data showed that the majority (n=100) of the isolates belonged to serogroup B...
May 9, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29739760/primary-meningococcal-septic-arthritis-with-multiple-native-joint-involvement
#10
Connor Boyle, Thomas Howard, David Griffith, Jonathan Cowie
A previously healthy 18-year-old woman presented with an acutely painful, swollen right ankle joint, with similar symptoms subsequently developing in the right hip and right wrist. Microbiological samples from the ankle aspirate grew Neisseria meningitidis She had had no preceding clinical symptoms of meningitis or previous contact with a patient with meningitis. She was treated with intravenous antibiotics and surgical drainage.On follow-up, her symptoms had resolved, inflammatory markers had returned to normal and she has no long-term sequelae of septic arthritis...
May 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29737965/identification-and-characterization-of-a-novel-single-chain-variable-fragment-scfv-antibody-against-neisseria-meningitidis-factor-h-binding-protein-fhbp
#11
Fatemeh Yarian, Bahram Kazemi, Mojgan Bandehpour
PURPOSE: Neisseria meningitidis is the leading global cause of meningitis and sepsis. Detection, followed by identification, of bacterial pathogens is important in medicine and public health. In the present study, we used the ribosome display technique to select single-chain variable fragments (scFv) that are specific to the surface-exposed fHbp antigen of N. meningitidis. METHODOLOGY: The recombinant fHbp protein was used as the antigen for the immunization of BALB/c mice...
May 8, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29735685/acquisition-of-virulence-genes-by-a-carrier-strain-gave-rise-to-the-ongoing-epidemics-of-meningococcal-disease-in-west-africa
#12
Ola Brønstad Brynildsrud, Vegard Eldholm, Jon Bohlin, Kennedy Uadiale, Stephen Obaro, Dominique A Caugant
In the African meningitis belt, a region of sub-Saharan Africa comprising 22 countries from Senegal in the west to Ethiopia in the east, large epidemics of serogroup A meningococcal meningitis have occurred periodically. After gradual introduction from 2010 of mass vaccination with a monovalent meningococcal A conjugate vaccine, serogroup A epidemics have been eliminated. Starting in 2013, the northwestern part of Nigeria has been affected by yearly outbreaks of meningitis caused by a novel strain of serogroup C Neisseria meningitidis (NmC)...
May 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29734757/capture-of-pb-2-and-cu-2-metal-cations-by-neisseria-meningitidis-type-capsular-polysaccharides
#13
Sujan Ghimire, Pumtiwitt C McCarthy
Heavy metal pollution of water is a significant environmental and public health concern. Current biological strategies for heavy metal removal from water are performed using microbial biopolymers, including polysaccharides, that are already fully formed. This creates limitations in adapting polysaccharides to increase binding affinity for specific metals. We propose that altering the specificity of polysaccharide-producing enzymes could be beneficial to improving metal capture by modified polysaccharides. We assess binding of Cu2+ and Pb2+ metal cations to Neisseria meningitidis -type polysaccharides...
May 5, 2018: Biomolecules
https://www.readbyqxmd.com/read/29724617/infections-by-emerging-serogroups-of-neisseria-meningitidis-a-case-report
#14
Felipe Pérez-García, Raquel Abad, Cristina Almirall, Elena Abarca
No abstract text is available yet for this article.
April 30, 2018: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29717974/surveillance-of-antimicrobial-resistance-in-neisseria-meningitidis-strains-isolated-from-invasive-cases-in-brazil-from-2009-to-2016
#15
Maria Cecília Gorla, Juliana Maira Watanabe Pinhata, Ueslei José Dias, Camile de Moraes, Ana Paula Lemos
PURPOSE: To describe the antimicrobial resistance profile of Neisseria meningitidis isolates causing invasive disease in Brazil from 2009 to 2016. METHODOLOGY: Among 3548 N. meningitidis isolates received, 2888 (81.4 %) were analysed for antimicrobial resistance using the broth microdilution technique, as recommended by the Clinical and Laboratory Standards Institute. Isolates were tested for ciprofloxacin, chloramphenicol, ceftriaxone, penicillin G, ampicillin and rifampin...
May 2, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29717697/adverse-events-following-immunisation-with-a-meningococcal-serogroup-b-vaccine-report-from-post-marketing-surveillance-germany-2013-to-2016
#16
Dirk Mentzer, Doris Oberle, Brigitte Keller-Stanislawski
Background and aimIn January 2013, a novel vaccine against Neisseria meningitidis serogroup B, the multicomponent meningococcal serogroup B vaccine (4CMenB), was approved by the European Medicines Agency. We aimed to evaluate the safety profile of this vaccine. Methods: All adverse events following immunisation (AEFI) reported from Germany since the vaccine's launch in Germany in November 2013 through December 2016 were reviewed and analysed. Results: Through December 2016, a total of 664 individual case safety reports (ICSR) notifying 1,960 AEFI were received...
April 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29709448/evaluation-of-the-association-of-pneumococcal-conjugate-vaccine-immunization-and-density-of-nasopharyngeal-bacterial-colonization-using-a-multiplex-quantitative-polymerase-chain-reaction-assay
#17
Courtney P Olwagen, Peter V Adrian, Marta C Nunes, Shabir A Madhi
BACKGROUND: Nasopharyngeal bacterial colonization is a pre-requisite for developing bacterial mucosal and invasive disease. Pneumococcal conjugate vaccine (PCV) immunization of children reduces their risk of colonization by vaccine-serotypes, which could affect the biome of the nasopharynx in relation to colonization by other bacteria. This study evaluated the association of PCV immunization on the prevalence density of nasopharyngeal colonization by common, potentially pathogenic bacteria...
April 27, 2018: Vaccine
https://www.readbyqxmd.com/read/29695936/invasive-meningococcal-disease-without-meningitis-a-forgotten-diagnosis
#18
Saqib Walayat, Nooreen Hussain, Abdullah H Malik, Elsa Vazquez-Melendez, Bhagat S Aulakh, Teresa Lynch
Neisseria meningitidis , a Gram-negative diplococcus, is an uncommon cause of pneumonia. There have been only about 344 cases reported worldwide from 1906 to 2015. To our knowledge, there have been only 3 cases reported in the USA in the past 2 decades. We present a case of a 72-year-old male with a past medical history of severe COPD, obstructive sleep apnea, and stage I lung cancer status post-stereotactic body radiation therapy 1 year ago, who was admitted with a 6-day history of productive cough with yellowish sputum, shortness of breath, extreme myalgias, and fatigue...
2018: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/29695781/the-bexsero-neisseria-meningitidis-serogroup-b-vaccine-antigen-nhba-is-a-high-affinity-chondroitin-sulfate-binding-protein
#19
Tsitsi D Mubaiwa, Lauren E Hartley-Tassell, Evgeny A Semchenko, Christopher J Day, Michael P Jennings, Kate L Seib
Neisseria meningitidis is a Gram-negative bacterial pathogen that causes life threatening meningitis and septicemia. Neisseria Heparin Binding Antigen (NHBA) is an outer membrane protein that binds heparin and heparan sulfate and DNA. This protein is one of the four antigens in the meningococcal serogroup B vaccine Bexsero. In the current study, we sought to define the full glycan-binding repertoire of NHBA to better understand its role in meningococcal pathogenesis and vaccine efficacy. Glycan array analysis revealed binding to 28 structures by recombinant NHBA...
April 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29667483/global-epidemiology-of-serogroup-b-meningococcal-disease-and-opportunities-for-prevention-with-novel-recombinant-protein-vaccines
#20
Rodolfo Villena, Marco Aurelio P Safadi, María Teresa Valenzuela, Juan P Torres, Adam Finn, Miguel O'Ryan
Meningococcal disease (MD) is a major cause of meningitis and sepsis worldwide, with a high case fatality rate and frequent sequelae. Neisseria meningitidis serogroups A, B, C, W, X and Y are responsible for most of these life-threatening infections, and its unpredictable epidemiology can cause outbreaks in communities, with significant health, social and economic impact. Currently, serogroup B is the main cause of MD in Europe and North America and one of the most prevalent serogroups in Latin America. Mass vaccination strategies using polysaccharide vaccines have been deployed since the 1970s and the use of conjugate vaccines has controlled endemic and epidemic disease caused by serogroups A, C, W and Y and more recently serogroup B using geographically-specific outer membrane vesicle based vaccines...
April 18, 2018: Human Vaccines & Immunotherapeutics
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