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https://www.readbyqxmd.com/read/28916450/capsule-switching-of-neisseria-meningitidis-sequence-type-7-serogroup-a-to-serogroup-x
#1
Xuemeng Ji, Ping-Ping Yao, Le-Yi Zhang, Yi Li, Fang Xu, Ling-Ling Mei, Shui-Rong Zhu, Yan-Jun Zhang, Han-Ping Zhu, Stijn van der Veen
OBJECTIVES: The bacterial pathogen Neisseria meningitidis is able to escape the currently available capsule-based vaccines by undergoing capsule switching. In this study, we investigated whether capsule switching has occurred in a recently emerged sequence type (ST) 7 serogroup X isolate in China, for which currently no vaccine is available. METHODS: To identify capsule switching breakpoints, the capsule locus and flanking regions of the ST-7 serogroup X isolate and three endemic ST-7 serogroup A isolates were sequenced and compared...
September 12, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28911029/necrotizing-fasciitis-caused-by-genogroup-%C3%A3-neisseria-meningitidis
#2
V Moris, A Chapuis, D Guillier, G Jeudy, M Huther, N Auffret, L Piroth, M Blot
No abstract text is available yet for this article.
September 1, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28904860/regulation-of-neisseria-meningitidis-cytochrome-bc1-components-by-nrrf-a-fur-controlled-small-noncoding-rna
#3
Yvonne Pannekoek, Robert Huis In 't Veld, Kim Schipper, Sandra Bovenkerk, Gertjan Kramer, Dave Speijer, Arie van der Ende
NrrF is a small regulatory RNA of the human pathogen Neisseria meningitidis. NrrF was previously shown to repress succinate dehydrogenase (sdhCDAB) under control of the ferric uptake regulator (Fur). Here, we provide evidence that cytochrome bc1 , encoded by the polycistronic mRNA petABC, is a NrrF target as well. We demonstrated differential expression of cytochrome bc1 comparing wild-type meningococci and meningococci expressing NrrF when sufficient iron is available. Using a gfp-reporter system monitoring translational control and target recognition of sRNA in Escherichia coli, we show that interaction between NrrF and the 5' untranslated region of the petABC mRNA results in its repression...
September 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28904187/genomic-characterization-of-urethritis-associated-neisseria-meningitidis-shows-that-a-wide-range-of-n-meningitidis-strains-can-cause-urethritis
#4
Kevin C Ma, Magnus Unemo, Samo Jeverica, Robert D Kirkcaldy, Hideyuki Takahashi, Makoto Ohnishi, Yonatan H Grad
Neisseria meningitidis, typically a resident of the oro- or nasopharynx and the causative agent of meningococcal meningitis and meningococcemia, is capable of invading and colonizing the urogenital tract. This can result in urethritis, akin to the syndrome caused by its sister species N. gonorrhoeae, the etiologic agent of gonorrhea. Recently, meningococcal strains associated with outbreaks of urethritis were reported to share genetic characteristics with gonococcus, raising the question of the extent to which these strains contain features that promote adaptation to the genitourinary niche, making them gonococcal-like and distinguishing them from other N...
September 13, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28892991/neisseria-meningitidis-causing-multiple-cerebral-abscesses-in-early-neonatal-period-case-report-and-review-of-literature
#5
Laxman Basani, Roja Aepala
Neisseria meningitidis is a rare cause of meningitis and septicemia in neonates. There are few published case reports of neonatal meningococcal meningitis complicated by subdural empyema, cerebral abscess and hydrocephalus. Few cases of neonatal meningococcal meningitis have been reported in the literature with none of them having the complication of multiple cerebral abscesses in early neonatal period (<seven days of life). We report a case of meningococcal meningitis with multiple cerebral abscesses which presented on fifth day of life and developed hydrocephalus at five weeks of life requiring a Ventriculo Peritoneal (VP) shunt...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28877506/cryoelectron-microscopy-reconstructions-of-the-pseudomonas-aeruginosa-and-neisseria-gonorrhoeae-type-iv-pili-at-sub-nanometer-resolution
#6
Fengbin Wang, Mathieu Coureuil, Tomasz Osinski, Albina Orlova, Tuba Altindal, Gaël Gesbert, Xavier Nassif, Edward H Egelman, Lisa Craig
We report here cryoelectron microscopy reconstructions of type IV pili (T4P) from two important human pathogens, Pseudomonas aeruginosa and Neisseria gonorrhoeae, at ∼ 8 and 5 Å resolution, respectively. The two structures reveal distinct arrangements of the pilin globular domains on the pilus surfaces, which impart different helical parameters, but similar packing of the conserved N-terminal α helices, α1, in the filament core. In contrast to the continuous α helix seen in the X-ray crystal structures of the P...
September 5, 2017: Structure
https://www.readbyqxmd.com/read/28873428/evaluation-of-robenidine-analog-ncl195-as-a-novel-broad-spectrum-antibacterial-agent
#7
Abiodun D Ogunniyi, Manouchehr Khazandi, Andrew J Stevens, Sarah K Sims, Stephen W Page, Sanjay Garg, Henrietta Venter, Andrew Powell, Karen White, Kiro R Petrovski, Geraldine Laven-Law, Eliane G Tótoli, Hérida R Salgado, Hongfei Pi, Geoffrey W Coombs, Dean L Shinabarger, John D Turnidge, James C Paton, Adam McCluskey, Darren J Trott
The spread of multidrug resistance among bacterial pathogens poses a serious threat to public health worldwide. Recent approaches towards combating antimicrobial resistance include repurposing old compounds with known safety and development pathways as new antibacterial classes with novel mechanisms of action. Here we show that an analog of the anticoccidial drug robenidine (4,6-bis(2-((E)-4-methylbenzylidene)hydrazinyl)pyrimidin-2-amine; NCL195) displays potent bactericidal activity against Streptococcus pneumoniae and Staphylococcus aureus by disrupting the cell membrane potential...
2017: PloS One
https://www.readbyqxmd.com/read/28867843/estimated-economic-impact-of-vaccinations-in-73-low-and-middle-income-countries-2001-2020
#8
Sachiko Ozawa, Samantha Clark, Allison Portnoy, Simrun Grewal, Meghan L Stack, Anushua Sinha, Andrew Mirelman, Heather Franklin, Ingrid K Friberg, Yvonne Tam, Neff Walker, Andrew Clark, Matthew Ferrari, Chutima Suraratdecha, Steven Sweet, Sue J Goldie, Tini Garske, Michelle Li, Peter M Hansen, Hope L Johnson, Damian Walker
OBJECTIVE: To estimate the economic impact likely to be achieved by efforts to vaccinate against 10 vaccine-preventable diseases between 2001 and 2020 in 73 low- and middle-income countries largely supported by Gavi, the Vaccine Alliance. METHODS: We used health impact models to estimate the economic impact of achieving forecasted coverages for vaccination against Haemophilus influenzae type b, hepatitis B, human papillomavirus, Japanese encephalitis, measles, Neisseria meningitidis serogroup A, rotavirus, rubella, Streptococcus pneumoniae and yellow fever...
September 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/28859312/phase-variation-of-dna-methyltransferases-and-the-regulation-of-virulence-and-immune-evasion-in-the-pathogenic-neisseria
#9
Kate L Seib, Freda E-C Jen, Adeana L Scott, Aimee Tan, Michael P Jennings
The pathogenic Neisseria provide textbook examples of phase variation: the high frequency, random and reversible switching of gene expression. Typically, phase variable gene expression is observed in genes required for the expression of surface proteins and carbohydrate structures. All Neisseria gonorrhoeae and N. meningitidis strains also express phase variable DNA methyltransferases that are components of DNA restriction-modification systems. Phase variation of these DNA methyltransferases (Mod) alters global DNA methylation patterns...
August 31, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28837693/alternative-vaccine-administration-by-powder-injection-needle-free-dermal-delivery-of-the-glycoconjugate-meningococcal-group-y-vaccine
#10
Nikolas T Weissmueller, Leanne Marsay, Heiko A Schiffter, Robert C Carlisle, Christine S Rollier, Robert K Prud'homme, Andrew J Pollard
Powder-injectors use gas propulsion to deposit lyophilised drug or vaccine particles in the epidermal and sub epidermal layers of the skin. We prepared dry-powder (Tg = 45.2 ± 0.5°C) microparticles (58.1 μm) of a MenY-CRM197 glyconjugate vaccine (0.5% wt.) for intradermal needle-free powder injection (NFPI). SFD used ultrasound atomisation of the liquid vaccine-containing excipient feed, followed by lyophilisation above the glass transition temperature (Tg' = - 29.9 ± 0.3°C). This resulted in robust particles (density~ 0...
2017: PloS One
https://www.readbyqxmd.com/read/28834957/adverse-events-following-vaccination-with-bivalent-rlp2086-trumenba%C3%A2-an-observational-longitudinal-study-during-a-college-outbreak-and-a-systematic-review
#11
Theresa M Fiorito, Grayson L Baird, Nicole Alexander-Scott, Suzanne Bornschein, Catherine Kelleher, Nan Du, Penelope H Dennehy
BACKGROUND: In February 2015, two unlinked culture-confirmed cases of Neisseria meningitidis serogroup B (MenB) disease occurred at a local college in Rhode Island ("college X") within three days. This represented a 489-fold increase in the incidence of MenB disease, and an outbreak was declared. For the first time, bivalent rLP2086 (Trumenba) was selected as a mandatory intervention response. A mass vaccination clinic was coordinated, which provided a unique opportunity to collect safety data in a real-world population of college-aged participants...
August 19, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28827496/cerebrospinal-fluid-cathelicidin-correlates-with-the-bacterial-load-and-outcomes-in-childhood-bacterial-meningitis
#12
Okko Savonius, Otto Helve, Irmeli Roine, Sture Andersson, Annika Saukkoriipi, Antonio González Mata, Heikki Peltola, Tuula Pelkonen
BACKGROUND: Large cerebrospinal fluid (CSF) bacterial load in bacterial meningitis (BM) relates to poor outcome. However, the antimicrobial peptide cathelicidin seems important to host defense. We studied how cathelicidin concentrations and bacterial load in CSF relate in childhood BM and to what extent they may predict the disease outcome. METHODS: The patient data originated from a large prospective clinical trial in Latin America in 1996-2003 in which the CSF samples were collected on admission (CSF1) and 12-24 hours later (CSF2)...
August 17, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28808592/a-case-of-fulminant-meningococcemia-it-is-all-in-the-complement
#13
Kellie L Hawkins, Mariah Hoffman, Sonia Okuyama, Sarah E Rowan
Eculizumab is a novel monoclonal antibody that inhibits complement-mediated hemolysis in patients with paroxysmal nocturnal hemoglobinuria (PNH). Complement deficiency is a well-known risk factor for meningococcal infection. We describe a case of a young patient with PNH treated with eculizumab who presented with a life-threatening case of nongroupable meningococcemia. As this new biologic agent becomes more widely prescribed, providers should be aware of the increased risk of meningococcemia. In addition to vaccination, providers may consider the use of oral penicillin for antibiotic prophylaxis against Neisseria meningitidis in these cases of functional complement deficiency...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28805699/predicting-and-interpreting-the-structure-of-type-iv-pilus-of-electricigens-by-molecular-dynamics-simulations
#14
Chuanjun Shu, Ke Xiao, Changchang Cao, Dewu Ding, Xiao Sun
Nanowires that transfer electrons to extracellular acceptors are important in organic matter degradation and nutrient cycling in the environment. Geobacter pili of the group of Type IV pilus are regarded as nanowire-like biological structures. However, determination of the structure of pili remains challenging due to the insolubility of monomers, presence of surface appendages, heterogeneity of the assembly, and low-resolution of electron microscopy techniques. Our previous study provided a method to predict structures for Type IV pili...
August 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28796795/investigation-of-correlates-of-protection-against-pharyngeal-carriage-of-neisseria-meningitidis-genogroups-w-and-y-in-the-african-meningitis-belt
#15
Laura V Cooper, Rahamatou Moustapha Boukary, Abraham Aseffa, Wude Mihret, Jean-Marc Collard, Doumagoum Daugla, Abraham Hodgson, Cheikh Sokhna, Babatunji Omotara, Samba Sow, Stephen Laryea Quaye, Kanny Diallo, Olivier Manigart, Martin C J Maiden, Helen Findlow, Ray Borrow, James M Stuart, Brian M Greenwood, Caroline L Trotter
BACKGROUND: Serum bactericidal antibody titres that correlate with protection against invasive meningococcal disease have been characterised. However, titres that are associated with protection against acquisition of pharyngeal carriage of Neisseria meningitidis are not known. METHODS: Sera were obtained from the members of a household in seven countries of the African meningitis belt in which a pharyngeal carrier of N. meningitidis had been identified during a cross-sectional survey...
2017: PloS One
https://www.readbyqxmd.com/read/28794055/effect-of-vaccine-elicited-antibodies-on-colonization-of-neisseria-meningitidis-serogroup-b-and-c-strains-in-a-human-bronchial-epithelial-cell-culture-model
#16
Vianca Vianzon, Beate Illek, Gregory R Moe
Capsular polysaccharide-protein conjugate vaccines protect individuals from invasive disease and decrease carriage, which reduces spread of the organism in the population. In contrast, antibodies elicited by plain polysaccharide or protein antigen-based meningococcal (Men) vaccines have little or no effect on decreasing carriage. In this study, we investigated the mechanism by which vaccine-induced human IgG antibodies affect colonization by serogroup B (MenB) or C (MenC) strains using a human bronchial epithelial cell culture model (16HBE14o-)...
August 9, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28781769/unraveling-neisseria-meningitidis-pathogenesis-from-functional-genomics-to-experimental-models
#17
REVIEW
Marco Soriani
Neisseria meningitidis is a harmless commensal bacterium finely adapted to humans. Unfortunately, under "privileged" conditions, it adopts a "devious" lifestyle leading to uncontrolled behavior characterized by the unleashing of molecular weapons causing potentially lethal disease such as sepsis and acute meningitis. Indeed, despite the lack of a classic repertoire of virulence genes in N. meningitidis separating commensal from invasive strains, molecular epidemiology and functional genomics studies suggest that carriage and invasive strains belong to genetically distinct populations characterized by an exclusive pathogenic potential...
2017: F1000Research
https://www.readbyqxmd.com/read/28771457/meningitis-outbreak-caused-by-vaccine-preventable-bacterial-pathogens-northern-ghana-2016
#18
Fortress Y Aku, Fernanda C Lessa, Franklin Asiedu-Bekoe, Phoebe Balagumyetime, Winfred Ofosu, Jennifer Farrar, Mahamoudou Ouattara, Jeni T Vuong, Kofi Issah, Joseph Opare, Sally-Ann Ohene, Charles Okot, Ernest Kenu, Donne K Ameme, David Opare, Abass Abdul-Karim
Bacterial meningitis is a severe, acute infection of the fluid surrounding the brain and spinal cord that can rapidly lead to death. Even with recommended antibiotic treatment, up to 25% of infected persons in Africa might experience neurologic sequelae (1). Three regions in northern Ghana (Upper East, Northern, and Upper West), located in the sub-Saharan "meningitis belt" that extends from Senegal to Ethiopia, experienced periodic outbreaks of meningitis before introduction of serogroup A meningococcal conjugate vaccine (MenAfriVac) in 2012 (2,3)...
August 4, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28770496/serogroup-b-meningococcus-outbreaks-prevalence-and-the-case-for-standard-vaccination
#19
REVIEW
James Grogan, Karen Roos
PURPOSE OF REVIEW: This review explores the history of serogroup B meningitis outbreaks in American universities and the rise of the monovalent serogroup B meningococcus vaccines (MenB). RECENT FINDINGS: Serogroup B meningitis represents 30% of American meningococcal infections and had no commercially available vaccine in the USA until 2013 when the FDA made an expanded allowance for importation of the MenB-4C vaccine for outbreaks at two American universities. Infections of Neisseria meningitidis, notably meningococcal meningitis represent a continued, lethal threat to the pediatric and adolescent populations and those with primary or acquired complement component deficiencies, largely mitigated by the quadrivalent meningococcal conjugated vaccine against serogroups A, C, W, and Y (MenACWY)...
September 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28770026/neisseria-lactamica-y92-1009-complete-genome-sequence
#20
Anish K Pandey, David W Cleary, Jay R Laver, Martin C J Maiden, Xavier Didelot, Andrew Gorringe, Robert C Read
We present the high quality, complete genome assembly of Neisseria lactamica Y92-1009 used to manufacture an outer membrane vesicle (OMV)-based vaccine, and a member of the Neisseria genus. The strain is available on request from the Public Health England Meningococcal Reference Unit. This Gram negative, dipplococcoid bacterium is an organism of worldwide clinical interest because human nasopharyngeal carriage is related inversely to the incidence of meningococcal disease, caused by Neisseria meningitidis. The organism sequenced was isolated during a school carriage survey in Northern Ireland in 1992 and has been the subject of a variety of laboratory and clinical studies...
2017: Standards in Genomic Sciences
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