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neisseria meningitidis

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https://www.readbyqxmd.com/read/29147875/evaluation-of-nfsa-like-nitroreductases-from-neisseria-meningitidis-and-bartonella-henselae-for-enzyme-prodrug-therapy-targeted-cellular-ablation-and-dinitrotoluene-bioremediation
#1
Michelle H Rich, Abigail V Sharrock, Kelsi R Hall, David F Ackerley, Joanna K MacKichan
OBJECTIVES: To characterize the activities of two candidate nitroreductases, Neisseria meningitidis NfsA (NfsA_Nm) and Bartonella henselae (PnbA_Bh), with the nitro-prodrugs, CB1954 and metronidazole, and the environmental pollutants 2,4- and 2,6-dinitrotoluene. RESULTS: NfsA_Nm and PnbA_Bh were evaluated in Escherichia coli over-expression assays and as His6-tagged proteins in vitro. With the anti-cancer prodrug CB1954, both enzymes were more effective than the canonical O2-insensitive nitroreductase E...
November 17, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/29136861/quality-by-design-approach-in-the-development-of-an-ultra-high-performance-liquid-chromatography-method-for-bexsero-meningococcal-group-b-vaccine
#2
Luca Nompari, Serena Orlandini, Benedetta Pasquini, Cristiana Campa, Michele Rovini, Massimo Del Bubba, Sandra Furlanetto
Bexsero is the first approved vaccine for active immunization of individuals from 2 months of age and older to prevent invasive disease caused by Neisseria meningitidis serogroup B. The active components of the vaccine are Neisseria Heparin Binding Antigen, factor H binding protein, Neisseria adhesin A, produced in Escherichia coli cells by recombinant DNA technology, and Outer Membrane Vesicles (expressing Porin A and Porin B), produced by fermentation of Neisseria meningitidis strain NZ98/254. All the Bexsero active components are adsorbed on aluminum hydroxide and the unadsorbed antigens content is a product critical quality attribute...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29132919/clonal-replacement-and-expansion-among-invasive-meningococcal-isolates-of-serogroup-w-in-france
#3
Eva Hong, Anne-Sophie Barret, Aude Terrade, Mélanie Denizon, Denise Antona, Myriam Aouiti-Trabelsi, Ala-Eddine Deghmane, Isabelle Parent du Châtelet, Daniel Levy-Bruhl, Muhamed-Kheir Taha
Background Neisseria meningitidis group W (NmW) belonging to the clonal complex ST-11 (NmW/cc11) spread in Europe and in France in 2000 and declined thereafter. In France, invasive meningococcal disease (IMD) due to NmW increased again in 2012 and thereafter since 2015. Several sub-lineages of NmW/cc11 are circulating worldwide with successive epidemic waves. We aimed to describe recent epidemiological trends of NmW in France and to explore the microbiological and epidemiological characteristics associated with different NmW/cc11 sub-lineages...
November 10, 2017: Journal of Infection
https://www.readbyqxmd.com/read/29121674/the-helicase-ding-responds-to-stress-due-to-dna-double-strand-breaks
#4
Stephan A Frye, Getachew Tesfaye Beyene, Amine Namouchi, Marta Gómez-Muñoz, Håvard Homberset, Shewit Kalayou, Tahira Riaz, Tone Tønjum, Seetha V Balasingham
Neisseria meningitidis (Nm) is a Gram-negative nasopharyngeal commensal that can cause septicaemia and meningitis. The neisserial DNA damage-inducible protein DinG is a helicase related to the mammalian helicases XPD and FANCJ. These helicases belong to superfamily 2, are ATP dependent and exert 5' → 3' directionality. To better understand the role of DinG in neisserial genome maintenance, the Nm DinG (DinGNm) enzymatic activities were assessed in vitro and phenotypical characterization of a dinG null mutant (NmΔdinG) was performed...
2017: PloS One
https://www.readbyqxmd.com/read/29114953/expanding-the-paradigm-for-the-outer-membrane-acinetobacter-baumannii-in-the-absence-of-endotoxin
#5
REVIEW
Matthew Joseph Powers, M Stephen Trent
Asymmetry in the outer membrane has long defined the cell envelope of Gram-negative bacteria. This asymmetry, with lipopolysaccharide (LPS) or lipooligosaccharide (LOS) exclusively in the outer leaflet of the membrane, establishes an impermeable barrier that protects the cell from a number of stressors in the environment. Work done over the past 5 years has shown that Acinetobacter baumannii has the remarkable capability to survive with inactivated production of lipid A biosynthesis and the absence of LOS in its outer membrane...
November 8, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/29103405/survival-of-neisseria-meningitidis-outside-of-the-host-environmental-effects-and-differences-among-strains
#6
C L Swain, D R Martin, D Sim, T W Jordan, J K Mackichan
Neisseria meningitidis is a gram-negative bacterium that lives as a commensal in the human nasopharynx. Meningococci are generally non-invasive, but can invade the nasopharyngeal epithelia and enter the bloodstream causing life-threatening illnesses. It is generally thought that meningococci do not survive for long outside the host, and that transmission requires relatively close contact between hosts. There are some reports, however, that meningococci can survive drying on surfaces, including glass, plastic and cloth...
November 6, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29099305/peripheral-blood-vessels-are-a-niche-for-blood-borne-meningococci
#7
Elena Capel, Jean-Philippe Barnier, Aldert L Zomer, Christine Bole-Feysot, Thomas Nussbaumer, Anne Jamet, Hervé Lécuyer, Daniel Euphrasie, Zoé Virion, Eric Frapy, Philippe Pélissier, Olivier Join-Lambert, Thomas Rattei, Sandrine Bourdoulous, Xavier Nassif, Mathieu Coureuil
Neisseria meningitidis is the causative agent of cerebrospinal meningitis and that of a rapidly progressing fatal septic shock known as purpura fulminans. Meningococcemia is characterized by bacterial adhesion to human endothelial cells of the microvessels. Host specificity has hampered studies on the role of blood vessels colonization in N. meningitidis associated pathogenesis. In this work, using a humanized model of SCID mice allowing the study of bacterial adhesion to human cells in an in vivo context we demonstrate that meningococcal colonization of human blood vessels is a prerequisite to the establishment of sepsis and lethality...
November 3, 2017: Virulence
https://www.readbyqxmd.com/read/29095907/bacterial-meningitis-epidemiology-and-return-of-neisseria-meningitidis-serogroup-a-cases-in-burkina-faso-in-the-five-years-following-menafrivac-mass-vaccination-campaign
#8
Alpha Oumar Diallo, Heidi M Soeters, Issaka Yameogo, Guetawendé Sawadogo, Flavien Aké, Clément Lingani, Xin Wang, Andre Bita, Amadou Fall, Lassana Sangaré, Rasmata Ouédraogo-Traoré, Isaïe Medah, Brice Bicaba, Ryan T Novak
BACKGROUND: Historically, Neisseria meningitidis serogroup A (NmA) caused large meningitis epidemics in sub-Saharan Africa. In 2010, Burkina Faso became the first country to implement a national meningococcal serogroup A conjugate vaccine (MACV) campaign. We analyzed nationwide meningitis surveillance data from Burkina Faso for the 5 years following MACV introduction. METHODS: We examined Burkina Faso's aggregate reporting and national laboratory-confirmed case-based meningitis surveillance data from 2011-2015...
2017: PloS One
https://www.readbyqxmd.com/read/29094312/meningococcal-quadrivalent-tetanus-toxoid-conjugate-vaccine-menacwy-tt-nimenrix-%C3%A2-a-review
#9
Sohita Dhillon, David Pace
MenACWY-TT (Nimenrix(®)) is a quadrivalent meningococcal tetanus toxoid conjugate vaccine licensed in Europe for active immunisation of individuals aged ≥ 6 weeks against invasive disease caused by Neisseria meningitidis capsular groups A, C, W and Y. MenACWY-TT is the first quadrivalent conjugate vaccine to be approved in Europe for use in infants as young as 6 weeks of age. Numerous phase II-IIIb clinical studies showed that intramuscular MenACWY-TT administered as primary or booster vaccination was highly immunogenic for all four vaccine capsular groups and had an acceptable reactogenicity profile in individuals aged 6 weeks to ≥ 56 years...
November 2017: Drugs
https://www.readbyqxmd.com/read/29093319/misidentification-of-neisseria-cinerea-as-neisseria-meningitidis-in-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-maldi-tof-ms
#10
Miyako Kawahara-Matsumizu, Yuka Yamagishi, Hiroshige Mikamo
No abstract text is available yet for this article.
October 31, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29083947/a-deeper-mining-on-the-protein-composition-of-va-mengoc-bc%C3%A2-an-omv-based-vaccine-against-n-meningitidis-serogroup-b-and-c
#11
Yordanka Masforrol, Jeovanis Gil, Darien García, Jesús Noda, Yassel Ramos, Lázaro Betancourt, Osmany Guirola, Sonia González, Boris Acevedo, Vladimir Besada, Osvaldo Reyes, Luis Javier González
The protein composition of an Outer Membrane Vesicle (OMV) preparation that constitutes the active pharmaceutical ingredient of VA-MENGOC-BC®, an effective vaccine against Neisseria meningitidis serogroups B, and C is presented. This preparation has a high lipid content and five abundant membrane proteins (FetA, PorA, PorB, RmpM, and Opc), constituting approximately 70% of the total protein mass. The protein composition was determined by combining the use of the Hexapeptide Ligand Library and an orthogonal tandem fractionation of tryptic peptides by reverse-phase chromatography at alkaline and acid pH...
October 30, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29083344/invasive-meningococcal-disease-on-the-workplaces-a-systematic-review
#12
Matteo Riccò, Luigi Vezzosi, Anna Odone, Carlo Signorelli
Background and aims of the work: Invasive Meningococcal Disease (IMD) represents a global health threat, and occupational settings have the potential to contribute to its spreading. Therefore, here we present the available evidences on the epidemiology of IMD on the workplaces. METHODS: The following key words were used to explore PubMed: Neisseria meningitidis, meningococcus, meningococcal, invasive meningococcal disease, epidemiology, outbreaks, profession(al), occupation(al). RESULTS: We identified a total of 12 IMD cases among healthcare workers (HCW), 44 involving biological laboratory workers (BLW), 8 among school personnel, and eventually 27 from other settings, including 3 large industrial working populations...
October 23, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29073269/nasal-carriage-rate-and-antibiotic-susceptibility-pattern-of-neisseria-meningitidis-in-healthy-ethiopian-children-and-adolescents-a-cross-sectional-study
#13
Tinsae Alemayehu, Amha Mekasha, Tamrat Abebe
BACKGROUND: Community nasal meningococcal carriage rates are high across Africa. Meningococcal infections are major causes of morbidity and mortality in the continent; especially among children and adolescents. This study aimed to determine the prevalence of nasal carriage and antibiotic susceptibilities of meningococcal isolates from healthy Ethiopian children and adolescents. METHOD: A cross-sectional study was conducted in one of the sub-cities of Addis Ababa, Ethiopia...
2017: PloS One
https://www.readbyqxmd.com/read/29073124/rapid-laboratory-identification-of-neisseria-meningitidis-serogroup-c-as-the-cause-of-an-outbreak-liberia-2017
#14
Jaymin C Patel, Josiah George, Jeni Vuong, Caelin C Potts, Catherine Bozio, Thomas A Clark, Jerry Thomas, Joshua Schier, Arthur Chang, Jessica L Waller, Maureen H Diaz, Melissa Whaley, Laurel T Jenkins, Serena Fuller, Desmond E Williams, John T Redd, Ray R Arthur, Fahn Taweh, Yatta Vera Walker, Patrick Hardy, Maxwell Freeman, Victoria Katawera, Gulu Gwesa, Miatta Z Gbanya, Peter Clement, Henry Kohar, Mardia Stone, Mosoka Fallah, Tolbert Nyenswah, Jonas M Winchell, Xin Wang, Lucy A McNamara, E Kainne Dokubo, LeAnne M Fox
On April 25, 2017, a cluster of unexplained illness and deaths among persons who had attended a funeral during April 21-22 was reported in Sinoe County, Liberia (1). Using a broad initial case definition, 31 cases were identified, including 13 (42%) deaths. Twenty-seven cases were from Sinoe County (1), and two cases each were from Grand Bassa and Monsterrado counties, respectively. On May 5, 2017, initial multipathogen testing of specimens from four fatal cases using the Taqman Array Card (TAC) assay identified Neisseria meningitidis in all specimens...
October 27, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29072886/rapid-field-response-to-a-cluster-of-illnesses-and-deaths-sinoe-county-liberia-april-may-2017
#15
John Doedeh, Joseph Asamoah Frimpong, Kwuakuan D M Yealue, Himiede W Wilson, Youhn Konway, Samson Q Wiah, Vivian Doedeh, Umaru Bao, George Seneh, Lawrence Gorwor, Sylvester Toe, Emmanuel Ghartey, Lawrence Larway, Dedesco Gweh, Philemon Gonotee, Thomas Paasewe, George Tamatai, James Yarkeh, Samuel Smith, Annette Brima-Davis, George Dauda, Thomas Monger, Leleh W Gornor-Pewu, Siafa Lombeh, Jeremias Naiene, Nathaniel Dovillie, Mark Korvayan, Geraldine George, Garrison Kerwillain, Ralph Jetoh, Suzanne Friesen, Carl Kinkade, Victoria Katawera, Maame Amo-Addae, Roseline N George, Miatta Z Gbanya, E Kainne Dokubo
On April 25, 2017, the Sinoe County Health Team (CHT) notified the Liberia Ministry of Health (MoH) and the National Public Health Institute of Liberia of an unknown illness among 14 persons that resulted in eight deaths in Sinoe County. On April 26, the National Rapid Response Team and epidemiologists from CDC, the World Health Organization (WHO) and the African Field Epidemiology Network (AFENET) in Liberia were deployed to support the county-led response. Measures were immediately implemented to identify all cases, ascertain the cause of illness, and control the outbreak...
October 27, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29071076/burden-of-bacterial-upper-respiratory-tract-pathogens-in-school-children-of-nepal
#16
Sangita Thapa, Shishir Gokhale, Annavarapu Laxminarasimha Sharma, Lokendra Bahadur Sapkota, Shamshul Ansari, Rajendra Gautam, Sony Shrestha, Puja Neopane
INTRODUCTION: Respiratory tract infections are one of the most common human infections in all age group and important cause of mortality and morbidity worldwide. Most bacterial upper respiratory tract infections are vaccine preventable. This study aimed to determine the prevalence of carrier state of bacterial upper respiratory tract pathogens among school children. It also aimed to study their antibiograms. METHODS: The specimen from posterior pharyngeal wall and tonsils were collected from 204 participants on calcium alginate coated swabs (HiMedia)...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29065137/differences-in-the-population-structure-of-neisseria-meningitidis-in-two-australian-states-victoria-and-western-australia
#17
Shakeel Mowlaboccus, Christopher A Mullally, Peter C Richmond, Benjamin P Howden, Kerrie Stevens, David J Speers, Anthony D Keil, Ottar N Bjørnstad, Timothy T Perkins, Charlene M Kahler
Neisseria meningitidis is the causative agent of invasive meningococcal disease (IMD). A recombinant vaccine called Bexsero® incorporates four subcapsular antigens (fHbp, NHBA, NadA and PorA) which are used to assign a Bexsero® antigen sequence type (BAST) to each meningococcal strain. The vaccine elicits an immune response against combinations of variants of these antigens which have been grouped into specific BAST profiles that have been shown to have different distributions within geographical locations thus potentially affecting the efficacy of the vaccine...
2017: PloS One
https://www.readbyqxmd.com/read/29057217/characterization-and-distribution-of-the-autb-gene-in-neisseria-meningitidis
#18
Aiyu Zhang, Pan Zhao, Bingqing Zhu, Fenglin Shi, Li Xu, Yuan Gao, Na Xie, Zhujun Shao
We aimed to investigate and understand the characterization and distribution of the autB gene in Neisseria meningitidis in China. autB is flanked by two conservative genes, smpB and glcD, and it can be present in the majority of meningococcal isolates, but not in 053442 of clonal complex 4821 (CC4821) which contains a 968 bp sequence. In this study, we sequenced the intervenient region between smpB and glcD in 178 Chinese N. meningitidis strains isolated from both patients and carriers. There were 110 serogroupable strains, other 68 were non-groupable (NG)...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29045638/subversion-of-nutritional-immunity-by-the-pathogenic-neisseriae
#19
Cynthia Nau Cornelissen
The pathogenic Neisseria species, including Neisseria meningitidis and Neisseria gonorrhoeae, are obligate human pathogens that cause significant morbidity and mortality. The success of these pathogens, with regard to causing disease in humans, is inextricably linked to their ability to acquire necessary nutrients in the hostile environment of the host. Humans deploy a significant arsenal of weaponry to defend against bacterial pathogens, not least of which are the metal sequestering proteins that entrap and withhold transition metals, including iron, zinc and manganese, from invaders...
October 13, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/29028166/continuing-risk-of-meningitis-due-to-neisseria-meningitidis-serogroup-c-in-africa-revised-recommendations-from-a-who-expert-consultation
#20
(no author information available yet)
No abstract text is available yet for this article.
October 13, 2017: Relevé épidémiologique Hebdomadaire
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