Manar Magdy Mahmoud Mohamed, Zhijie Yang, Kah Yean Lum, Gundela Peschel, Miriam A Rosenbaum, Tilmann Weber, Sonia Coriani, Charlotte H Gotfredsen, Ling Ding
Ansamycins, represented by the antituberculosis drug rifamycin, are an important family of natural products. To obtain new ansamycins, Streptomyces rapamycinicus IMET 43975 harboring an ansamycin biosynthetic gene cluster was fermented in a 50 L scale, and subsequent purification work led to the isolation of five known and four new analogues, where hygrocin W ( 2 ) belongs to benzoquinonoid ansamycins, and the other three hygrocins, hygrocins X-Z ( 6 - 8 ), are new seco-hygrocins. The structures of ansamycins ( 1 - 8 ) were determined by the analysis of spectroscopic (1D/2D NMR and ECD) and MS spectrometric data...
April 22, 2024: Journal of Natural Products