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https://www.readbyqxmd.com/read/28064080/first-principles-study-for-the-key-electronic-optical-and-nonlinear-optical-properties-of-novel-donor-acceptor-chalcones
#1
Shabbir Muhammad, Abdullah G Al-Sehemi, Zhongmin Su, Hongliang Xu, Ahmad Irfan, Aijaz Rasool Chaudhry
Using first-principle methods, several key electronic, optical and nonlinear optical properties are calculated for two recently synthesized chalcone derivatives i.e. (2E)-3-(4-methylphenyl)-1-(3-nitrophenyl)prop-2-en-1-one (comp.1) and (2E)-3-[4-(dimethylamino)phenyl]-1-(3-nitrophenyl)prop-2-en-1-one (comp.2). The calculation of dipole moment, polarizability <α>, anisotropy of polarizability as well as second hyperpolarizability (usually considered as a signature for two photon absorption phenomenon) are performed using density functional theory methods at PBE0/6-311G** level of theory...
December 14, 2016: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28057075/the-efficacy-of-prospective-memory-rehabilitation-plus-metacognitive-skills-training-for-adults-with-traumatic-brain-injury-study-protocol-for-a-randomized-controlled-trial
#2
Jennifer Fleming, Tamara Ownsworth, Emmah Doig, Lauren Hutton, Janelle Griffin, Melissa Kendall, David H K Shum
BACKGROUND: Impairment of prospective memory (PM) is common following traumatic brain injury (TBI) and negatively impacts on independent living. Compensatory approaches to PM rehabilitation have been found to minimize the impact of PM impairment in adults with TBI; however, poor self-awareness after TBI poses a major barrier to the generalization of compensatory strategies in daily life. Metacognitive skills training (MST) is a cognitive rehabilitation approach that aims to facilitate the development of self-awareness in adults with TBI...
January 5, 2017: Trials
https://www.readbyqxmd.com/read/28056936/a-12-week-randomized-double-blind-placebo-controlled-multicenter-study-of-choline-stabilized-orthosilicic-acid-in-patients-with-symptomatic-knee-osteoarthritis
#3
Piet Geusens, Karel Pavelka, Jozef Rovensky, Johan Vanhoof, Nathalie Demeester, Mario Calomme, Dirk Vanden Berghe
BACKGROUND: The aim of this study was to assess the efficacy of choline-stabilized orthosilicic acid (ch-OSA) in patients with symptomatic knee osteoarthritis (OA). METHODS: In a multicenter, double-blind, placebo-controlled study, 211 patients with knee OA (Kellgren and Lawrence grade II or III) and moderate to moderately severe pain were randomly allocated to ch-OSA or placebo for 12 weeks. The primary outcome was the change in the WOMAC pain subscale from baseline to week 12...
January 5, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28046695/mo-de-bra-03-the-ottawa-medical-physics-institute-ompi-a-practical-model-for-academic-program-collaboration-in-a-multi-centre-city
#4
M McEwen, D Rogers, P Johns/Sup
PURPOSE: To build a world-class medical physics educational program that capitalizes on expertise distributed over several clinical, government, and academic centres. Few if any of these centres would have the critical mass to solely resource a program. METHODS: In order to enable an academic program, stakeholders from five institutions made a proposal to Carleton University for a) a research network with defined membership requirements and a process for accepting new members, and b) a graduate specialization (MSc and PhD) in medical physics...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044000/painful-locking-of-the-wrist-in-a-patient-with-pseudoachondroplasia-confirmed-by-comp-mutation
#5
Hirokazu Ideta, Shigeharu Uchiyama, Masanori Hayashi, Tomoki Kosho, Yukio Nakamura, Hiroyuki Kato
We report the case of a 40-year-old woman with pseudoachondroplasia (PSACH), with a heterozygous mutation (c.806A > G, p.Asp269Gly) located in the Type 3 repeats domain of the cartilage oligomeric matrix protein gene, who complained of the unusual symptom of painful locking of the wrist. Her condition was caused by a non-traumatic enlargement of the extensor carpi radialis longus (ECRL) and brevis (ECRB) tendons along with bulbous swelling of the synoviums around them. Surgical treatment resolved these unusual tendon-related symptoms...
January 2, 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28038353/decellularized-adipose-tissue-microcarriers-as-a-dynamic-culture-platform-for-human-adipose-derived-stem-stromal-cell-expansion
#6
Claire Yu, Anna Kornmuller, Cody Brown, Todd Hoare, Lauren E Flynn
With the goal of designing a clinically-relevant expansion strategy for human adipose-derived stem/stromal cells (ASCs), methods were developed to synthesize porous microcarriers derived purely from human decellularized adipose tissue (DAT). An electrospraying approach was applied to generate spherical DAT microcarriers with an average diameter of 428 ± 41 μm, which were soft, compliant, and stable in long-term culture without chemical crosslinking. Human ASCs demonstrated enhanced proliferation on the DAT microcarriers relative to commercially-sourced Cultispher-S microcarriers within a spinner culture system over 1 month...
December 23, 2016: Biomaterials
https://www.readbyqxmd.com/read/28034862/comp-pc-esmon-ct-activated-protein-c-inhibits-platelet-prothrombin-converting-activity-blood-1979-54-6-1272-1281
#7
(no author information available yet)
No abstract text is available yet for this article.
December 29, 2016: Blood
https://www.readbyqxmd.com/read/28031187/phosd-inferring-kinase-substrate-interactions-based-on-protein-domains
#8
Gui-Min Qin, Rui-Yi Li, Xing-Ming Zhao
MOTIVATION: Identifying the kinase-substrate relationships is vital to understanding the phosphorylation events and various biological processes, especially signal transductions. Although large amount of phosphorylation sites have been detected, unfortunately, it is rarely known which kinases activate those sites. Despite distinct computational approaches have been proposed to predict the kinase-substrate interactions, the prediction accuracy still needs to be improved. RESULTS: In this paper, we propose a novel probabilistic model named as PhosD to predict kinase-substrate relationships based on protein domains with the assumption that kinase-substrate interactions are accomplished with kinase-domain interactions...
December 28, 2016: Bioinformatics
https://www.readbyqxmd.com/read/28028161/cartilage-biomarkers-in-the-osteoarthropathy-of-alkaptonuria-reveal-low-turnover-and-accelerated-ageing
#9
Adam M Taylor, Ming-Feng Hsueh, Lakshminarayan R Ranganath, James A Gallagher, Jane P Dillon, Janet L Huebner, Jon B Catterall, Virginia B Kraus
OBJECTIVE: Alkaptonuria (AKU) is a rare autosomal recessive disease resulting from a single enzyme deficiency in tyrosine metabolism. As a result, homogentisic acid cannot be metabolized, causing systemic increases. Over time, homogentisic acid polymerizes and deposits in collagenous tissues, leading to ochronosis. Typically, this occurs in joint cartilages, leading to an early onset, rapidly progressing osteoarthropathy. The aim of this study was to examine tissue turnover in cartilage affected by ochronosis and its role in disease initiation and progression...
January 2017: Rheumatology
https://www.readbyqxmd.com/read/28012106/osteogenic-potential-of-the-transcription-factor-c-myb
#10
V Oralova, E Matalova, M Killinger, L Knopfova, J Smarda, M Buchtova
The transcription factor c-MYB is a well-known marker of undifferentiated cells such as haematopoietic cell precursors, but recently it has also been observed in differentiated cells that produce hard tissues. Our previous findings showed the presence of c-MYB in intramembranous bones and its involvement in the chondrogenic steps of endochondral ossification, where the up-regulation of early chondrogenic markers after c-myb overexpression was observed. Since we previously detected c-MYB in osteoblasts, we aimed to analyse the localisation of c-MYB during later stages of endochondral bone formation and address its function during bone matrix production...
December 24, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/28002895/hybrid-complexes-of-high-and-low-molecular-weight-evaluation-using-an-in-vitro-model-of-osteoarthritis
#11
A Stellavato, F De Novellis, S Reale, M De Rosa, C Schiraldi
Hyaluronan (HA) is central in joint and cartilage functions and to restore synovial fluid viscosity. In patients with osteoarthritis (OA), molecular weight (MW) and concentration of hyaluronic acid (HA) are reduced, diminishing joint lubrication. IL-1β treatment was used to mimic osteoarthritis in a chondrocytes based in vitro model. The aim of our research, using this model and human chondrocytes was to assess the anti-inflammatory effect of H/L-HA hybrid complexes (SINOVIAL-HL®) in comparison with HA at high (H-HA) and low molecular weight (L-HA) separately used, through the evaluation of specific biomarkers involved in cartilage degradation and correlated to osteoarthritis...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28000484/nutrici%C3%A3-n-parenteral-domiciliaria-en-espa%C3%A3-a-durante-2015-informe-del-grupo-de-nutrici%C3%A3-n-artificial-domiciliaria-y-ambulatoria-nadya
#12
Carmina Wanden-Berghe Lozano, Cristina Campos Martín, Cristina Cuerda Compes, Carmen Gómez Candela, Rosa Burgos Peláez, José Manuel Moreno Villares, José Luis Pereira Cunill, Antonio Pérez de la Cruz, Nuria Virgili Casas, Ceferino Martinez Faedo, Julia Álvarez Hernández, Carmen Garde Orbaiz, Mª Ángeles Penacho Lázaro, Eva Ángeles Sánchez Martos, Alejandro Sanz Paris, Montserrat Gonzalo Marín, Ana Zugasti Murillo, Pilar Matía Martín, Tomás Martín Folgueras, Fátima Carabaña Pérez, Patricia Díaz Guardiola, Cristina Tejera Pérez, Daniel De Luis Román, Luis Miguel Luengo Pérez, Nieves Santacruz Carmona, Antxón Apezetxea Celaya, Miguel Ángel Ponce González, Juan Ramón Urgeles Planella, Lucía Laborda González, Miguel Ángel Martinez Olmos, Olga Sánchez-Vilar Burdiel, Clara Joaquín Ortiz, Cecilia Martínez Costa, José Pablo Suárez Llanos, Alicia Calleja Fernández, Pere Leyes García, Mª Carmen Gil Martinez, Silvia Mauri Roca, Maria Victoria García Zafra, María José Carrera Santaliestra, Grupo Nadya-Senpe
Objetivo: Comunicar los datos del registro de Nutrición Parenteral Domiciliaria (NPD) del grupo de trabajo NADYA-SENPE del años 2015.Material y métodos: Recopilación de los datos de NPD del registro "on-line" del grupo de Nutrición Artificial Domiciliaria y Ambulatoria (NADYA) desde el 1 de enero de 2015 al 31 de diciembre de 2015.Resultados: Se registraron 236 pacientes, con 243 episodios de NPD procedentes de 40 hospitales. Lo que representa una tasa de 5,08 pacientes/millón de habitantes/ año 2015...
November 29, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27997067/rotenone-and-elevated-extracellular-potassium-concentration-induce-cell-specific-fibrillation-of-%C3%AE-synuclein-in-axons-of-cholinergic-enteric-neurons-in-the-guinea-pig-ileum
#13
D F Sharrad, B N Chen, W P Gai, N Vaikath, O M El-Agnaf, S J H Brookes
BACKGROUND: Parkinson's disease is a progressive neurodegenerative disorder that results in the widespread loss of select classes of neurons throughout the nervous system. The pathological hallmarks of Parkinson's disease are Lewy bodies and neurites, of which α-synuclein fibrils are the major component. α-Synuclein aggregation has been reported in the gut of Parkinson's disease patients, even up to a decade before motor symptoms, and similar observations have been made in animal models of disease...
November 7, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27988824/rats-acquisition-of-the-ephemeral-reward-task
#14
Thomas R Zentall, Jacob P Case, Jonathon R Berry
The ephemeral reward task provides a subject with a choice between two alternatives A and B. If it chooses alternative A, reinforcement follows and the trial is over. If it chooses alternative B, reinforcement follows but the subject can also respond to alternative A which is followed by a second reinforcement. Thus, it would be optimal to choose alternative B. Surprisingly, Salwiczek et al. (PLoS One 7:e49068, 2012. doi: 10.1371/journal.pone.00490682012 ) reported that adult fish (cleaner wrasse) mastered this task within 100 trials, whereas monkeys and apes had great difficulty with it...
December 17, 2016: Animal Cognition
https://www.readbyqxmd.com/read/27988350/quantitative-proteomics-analysis-of-cartilage-response-to-mechanical-injury-and-cytokine-treatment
#15
Yang Wang, Yang Li, Areej Khabut, Susan Chubinskaya, Alan J Grodzinsky, Patrik Önnerfjord
Mechanical damage at the time of joint injury and the ensuing inflammatory response associated with elevated levels of pro-inflammatory cytokines in the synovial fluid, are reported to contribute to the progression to osteoarthritis after injury. In this exploratory study, we used a targeted proteomics approach to follow the progression of matrix degradation in response to mechanical damage and cytokine treatment of human knee cartilage explants, and thereby to study potential molecular biomarkers. This proteomics approach allowed us to unambiguously identify and quantify multiple peptides and proteins in the cartilage medium and explants upon treatment with ±injurious compression ±cytokines, treatments that mimic the earliest events in post-traumatic OA...
December 15, 2016: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/27965483/surface-hardness-of-dental-composite-resin-restorations-in-response-to-preventive-agents
#16
Khalid H Al-Samadani
INTRODUCTION: To assess the impact of using preventive mouthwash agents on the surface hardness of various resins composites. MATERIALS AND METHODS: Hundred specimens were prepared from five types of composite resin material in a Teflon mold. Five specimens from each type of restorative materials (Herculite XRV Ultra, Estelite Σ Quick, Z Hermack, Versa Comp Sultan, and Empress Direct IPS) were evaluated posttreatment with immersion in four types of preventive mouthwashes gels and rinses - group 1: Flocare gel (0...
December 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27942954/assessment-of-gas-compression-and-lung-volume-during-air-stacking-maneuver
#17
A Sarmento, V R Resqueti, G A F Fregonezi, A Aliverti
PURPOSE: We reasoned that the application of positive pressure through air stacking (AS) technique could cause gas compression and the absolute lung volumes could be estimated. The aim of this study was to estimate the amount of gas compression (ΔV comp) during AS in healthy subjects positioned at 45° trunk inclination and verify if the simultaneous measurements of chest wall volume changes (ΔV CW), by optoelectronic plethysmography, and changes in lung volume (ΔV ao), by pneumotachograph, combined with pressure variation at the airways opening (ΔP ao) during AS are able to provide reliable data on absolute lung volumes...
December 9, 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27937044/3-hydroxy-4-7-megastigmadien-9-one-isolated-from-ulva-pertusa-attenuates-tlr9-mediated-inflammatory-response-by-down-regulating-mitogen-activated-protein-kinase-and-nf-%C3%AE%C2%BAb-pathways
#18
Irshad Ali, Zahid Manzoor, Jung-Eun Koo, Jung-Eun Kim, Sang-Hee Byeon, Eun-Sook Yoo, Hee-Kyoung Kang, Jin-Won Hyun, Nam-Ho Lee, Young-Sang Koh
CONTEXT: Seaweeds are rich in bioactive compounds in the form of vitamins, phycobilins, polyphenols, carotenoids, phycocyanins and polysaccharides; many of these are known to have advantageous applications in human health. 3-Hydroxy-4,7-megastigmadien-9-one (comp) was isolated from Ulva pertusa (U. pertusa) Kjellman (Ulvaceae), which is a familiar edible green seaweed. OBJECTIVE: This study evaluates the anti-inflammatory activity of comp in CpG DNA-stimulated bone marrow-derived dendritic cells (BMDCs)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27929701/effect-of-serum-and-platelet-rich-plasma-on-human-early-or-advanced-degenerative-meniscus-cells
#19
Undine Freymann, Lucia Degrassi, Jan Philipp Krüger, Sebastian Metzlaff, Michaela Endres, Wolf Petersen
PURPOSE: The purpose of this in vitro study was to evaluate the migratory, proliferating & extracellular matrix (ECM) forming effect of human serum (HS) and platelet-rich plasma (PRP) on meniscus cells derived from human knees with early or advanced degenerative changes. MATERIALS AND METHODS: Medial menisci from knees with early degenerative changes (n=5; mean Kellgren score of 1) undergoing arthroscopic meniscal surgery and advanced degenerative changes (n=5; mean Kellgren score of 4) undergoing total knee replacement were collected...
December 8, 2016: Connective Tissue Research
https://www.readbyqxmd.com/read/27929477/production-review-and-impact-of-technical-quality-control-guidelines-in-a-national-context
#20
Michelle K Nielsen, Kyle E Malkoske, Erika Brown, Kevin Diamond, Normand Frenière, John Grant, Natalie Pomerleau-Dalcourt, Jason Schella, L John Schreiner, Laurent Tantôt, J Eduardo Villareal-Barajas, Jean-Pierre Bissonnette
A close partnership between the Canadian Partnership for Quality Radiotherapy (CPQR) and the Canadian Organization of Medical Physicist's (COMP) Quality Assurance and Radiation Safety Advisory Committee (QARSAC) has resulted in the development of a suite of Technical Quality Control (TQC) guidelines for radiation treatment equipment; they outline specific performance objectives and criteria that equipment should meet in order to assure an acceptable level of radiation treatment quality. The adopted framework for the development and maintenance of the TQCs ensures the guidelines incorporate input from the medical physics com-munity during development, measures the workload required to perform the QC tests outlined in each TQC, and remain relevant (i...
November 8, 2016: Journal of Applied Clinical Medical Physics
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