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https://www.readbyqxmd.com/read/28625746/the-fragmentation-mechanism-and-immune-protective-effect-of-cftep-in-the-scallop-chlamys-farreri
#1
Zhuang Xue, Leilei Wang, Zhaoqun Liu, Weilin Wang, Chang Liu, Xiaorui Song, Lingling Wang, Linsheng Song
Thioester-containing proteins (TEPs), characterized by a unique intrachain β-cysteinyl-γ-glutamyl thioester bond, form an ancient and diverse family of secreted proteins that play central roles in the innate immune response. But the existence form and immune protection mechanism of TEP in invertebrates still remain unclear, especially in the mollusks. The fragmentation and the immune-protective effect of thioester bond in CfTEP, a previously identified thioester-containing protein in scallop Chlamys farreri, were characterized in the present study...
June 15, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28602855/effects-of-substrate-stiffness-on-the-tenoinduction-of-human-mesenchymal-stem-cells
#2
Anowarul Islam, Thomas Mbimba, Mousa Younesi, Ozan Akkus
Extracellular matrix modulus plays an important role in regulating cell morphology, proliferation and differentiation during regular and diseased states. Although the effects of substrate topography and modulus on MSC differentiation are well known with respect to osteogenesis and adipogenesis, there has been relatively little investigation on the effects of this phenomenon on tenogenesis. Furthermore, relative roles of topographical factors (matrix alignment vs. matrix modulus) in inducing tenogenic differentiation is not well understood...
June 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28602782/associations-between-serum-ghrelin-and-knee-symptoms-joint-structures-and-cartilage-or-bone-biomarkers-in-patients-with-knee-osteoarthritis
#3
J Wu, K Wang, J Xu, G Ruan, Q Zhu, J Cai, J Ren, S Zheng, Z Zhu, P Otahal, C Ding
OBJECTIVE: The roles of ghrelin in knee osteoarthritis (OA) are unclear. This study aimed to examine cross-sectional associations of ghrelin with knee symptoms, joint structures and cartilage or bone biomarkers in patients with knee OA. METHODS: This study included 146 patients with symptomatic knee OA. Serum levels of ghrelin and cartilage or bone biomarkers including cartilage oligomeric matrix protein (COMP), cross linked C-telopeptide of type I collagen (CTXI), cross linked N-telopeptide of type I collagen (NTXI), N-terminal procollagen III propeptide (PIIINP), and matrix metalloproteinase (MMP)-3, 10, 13 were measured using Enzyme-linked immunosorbent assay (ELISA)...
June 15, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28601877/successful-treatment-of-neonatal-respiratory-transitional-disorder-with-pulmo-vivianit-comp-in-2-cases
#4
Benedikt M Huber, Dirk Bassler
No abstract text is available yet for this article.
June 12, 2017: Complementary Medicine Research
https://www.readbyqxmd.com/read/28586207/primadorac-a-free-web-interface-for-the-assignment-of-partial-charges-chemical-topology-and-bonded-parameters-in-organic-or-drug-molecules
#5
Piero Procacci
We present PrimaDORAC, a simple and freely accessible web interface for generating the topology and the parameter files of organic or drug molecules, to be used in molecular mechanics or molecular dynamics calculations. The interface relies on our in-house FORTRAN90 parser, working on the recently released Generalized Amber Force Field parameter set (GAFF2). AM1/BCC charges are computed using the Public Domain MOPAC7 program and the bond charge corrections (BCC) reported in Ref. Jakalian et al, J Comp Chem, 2002, 23, 1623-1641...
June 6, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28585857/la-polifarmacia-del-paciente-cr%C3%A3-nico-complejo-y-la-nutrici%C3%A3-n-enteral
#6
Rosa Mª Romero Jiménez, Cristina Ortega Navarro, Cristina Cuerda Compés
La administración del tratamiento farmacológico en pacientes crónicos complejos tiene que realizarse en numerosas ocasiones por la misma vía por la que se administra la nutrición enteral. Es importante tener en cuenta la posibilidad de aparición de interacciones, ya que podrían producirse problemas asociados, como una pérdida de la efectividad del tratamiento farmacológico o una obstrucción de la sonda. Este tipo de pacientes suele tener un alto riesgo de presentar incompatibilidades de su tratamiento farmacológico con la nutrición enteral, debido a que se debe modificar en numerosas ocasiones la forma farmacéutica para la administración por sonda o enterostomía...
May 8, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28579384/managing-molars-with-severe-molar-incisor-hypomineralization-a-cost-effectiveness-analysis-within-german-healthcare
#7
Karim Elhennawy, Paul-Georg Jost-Brinkmann, David John Manton, Sebastian Paris, Falk Schwendicke
OBJECTIVES: Dentists have a range of options for managing molars with severe molar-incisor hypomineralization (MIH), each with different long-term implications. The cost-effectiveness of managing molars with severe MIH was assessed. METHODS: A mixed public-private-payer perspective within German healthcare was adopted. Individuals with one to four severely MIH-affected molars were followed over their lifetime. We compared: (1) removal of the tooth/teeth and orthodontic alignment of the second and third molars (Ex/Ortho); (2) restoration of the tooth using resin composite (Comp); (3) restoration using an indirect metal crown after temporizing it using a preformed metal crown (PMC/IR)...
June 1, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28561904/neonatal-abstinence-syndrome-neurobehavior-at-6-weeks-of-age-in-infants-with-or-without-pharmacological-treatment-for-withdrawal
#8
Nicole A Heller, Beth A Logan, Deborah G Morrison, Jonathan A Paul, Mark S Brown, Marie J Hayes
Use and abuse of prescription opioids and concomitant increase in Neonatal Abstinence Syndrome (NAS), a condition that may lead to protracted pharmacological treatment in more than 60% of infants, has tripled since 2000. This study assessed neurobehavioral development using the NICU Network Neurobehavioral Scale in 6-week old infants with prenatal methadone exposure who did (NAS+; n = 23) or did not (NAS-; n = 16) require pharmacological treatment for NAS severity determined by Finnegan Scale. An unexposed, demographically similar group of infants matched for age served as comparison (COMP; n = 21)...
May 31, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28542244/a-quantitative-label-free-analysis-of-the-extracellular-proteome-of-human-supraspinatus-tendon-reveals-damage-to-the-pericellular-and-elastic-fibre-niches-in-torn-and-aged-tissue
#9
Osnat Hakimi, Nicola Ternette, Richard Murphy, Benedikt M Kessler, Andrew Carr
Tears of the human supraspinatus tendon are common and often cause painful and debilitating loss of function. Progressive failure of the tendon leading to structural abnormality and tearing is accompanied by numerous cellular and extra-cellular matrix (ECM) changes in the tendon tissue. This proteomics study aimed to compare torn and aged rotator cuff tissue to young and healthy tissue, and provide the first ECM inventory of human supraspinatus tendon generated using label-free quantitative LC-MS/MS. Employing two digestion protocols (trypsin and elastase), we analysed grain-sized tendon supraspinatus biopsies from older patients with torn tendons and from healthy, young controls...
2017: PloS One
https://www.readbyqxmd.com/read/28536825/intramuscular-clodronate-in-erosive-osteoarthritis-of-the-hand-is-effective-on-pain-and-reduces-serum-comp-a-randomized-pilot-trial-the-er-o-d-e-study-erosive-osteoarthritis-and-disodium-clodronate-evaluation
#10
Gianantonio Saviola, Lul Abdi-Ali, Maria Rosaria Povino, Lorella Campostrini, Silvano Sacco, Luca Dalle Carbonare
We evaluated the efficacy and safety of intramuscular clodronate (CLO) for the treatment of active erosive osteoarthritis of the hand (EOA). Forty outpatients treated with anti-inflammatory (NSAIDs) or analgesic drugs since at least 6 months, for at least 3 days a week, were randomly divided into two groups. Group A: 24 patients treated for 6 months with intramuscular (i.m.) CLO added to usual NSAIDs or analgesic drugs. The attack dose was 200 mg/day i.m. for 10 days followed by a maintenance dose of CLO i...
May 23, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28525322/a-systemic-review-of-existing-serological-possibilities-to-diagnose-canine-osteoarthritis-with-a-particular-focus-on-extracellular-matrix-proteoglycans-and-protein
#11
M Shahid, G Manchi, P Slunsky, O Naseer, A Fatima, B Leo, J Raila
Extra-cellular matrix (ECM) components are important and their stabilization is significant in maintaining normal healthy joint environment. In osteoarthritis (OA), ECM components are altered and indicate disease progression. The joint ECM is composed of proteoglycans (aggrecan, perlecan, inter α-trypsin inhibitor), glycoproteins (fibronectin, lubricin, COMP) and collagen types (most abundantly collagen type II) which represent structural and functional transformation during disease advancement. ECM investigation revealed significant biomarkers of OA that could be used as a diagnostic and therapeutic tool in different canine orthopedic diseases...
March 28, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28524259/nonpegylated-liposomal-doxorubicin-combination-regimen-in-patients-with-diffuse-large-b-cell-lymphoma-and-cardiac-comorbidity-results-of-the-heart01-phase-ii-trial-conducted-by-the-fondazione-italiana-linfomi
#12
Stefano Luminari, Elda Viel, Andrés José Maria Ferreri, Francesco Zaja, Emanuela Chimienti, Gerardo Musuraca, Alessandra Tucci, Monica Balzarotti, Monica Tani, Francesca Salvi, Emanuela A Pesce, Angela Ferrari, Anna M Liberati, Antonio Spadea, Dario Marino, Maria Bruno-Ventre, Stefano Volpetti, Chiara Bottelli, Elena Ravaioli, Francesco Merli, Michele Spina
The purpose of this phase 2, multicenter study was to determine the activity and safety of nonpegylated liposomal doxorubicin as part of "R-COMP" combination in patients with diffuse large B-cell lymphoma and coexisting cardiac disorders. The study was conducted using a Bayesian continuing assessment method using complete remission rate and rate of cardiac events as study endpoints. Between November 2009 and October 2011, 50 evaluable patients were enrolled (median age, 76 years). Median baseline left ventricular ejection fraction (LVEF) was 60%...
May 19, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28522284/corrigendum-to-development-of-a-new-pcr-based-assay-to-detect-anaplasmataceae-and-the-first-report-of-anaplasma-phagocytophilum-and-anaplasma-platys-in-cattle-from-algeria-comp-immunol-microbiol-infect-dis-4-39-2015-39-45-elsevier-ltd
#13
Mustapha Dahmani, Bernard Davoust, Mohamed Seghir Benterki, Florence Fenollar, Didier Raoult, Oleg Mediannikov
No abstract text is available yet for this article.
May 15, 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28514897/biomaterials-and-bioactive-agents-in-spinal-fusion
#14
Rui M Duarte, Pedro Varanda, Rui L Reis, Ana Rita C Duarte, Jorge Correia-Pinto
Management of degenerative spine pathologies frequently leads to the need for spinal fusion, where bone growth is induced towards stabilization of the interventioned spine. Autologous bone graft (ABG) remains the gold standard inducer, while new bone graft substitutes attempt to achieve effective de novo bone formation and solid fusion. Limited fusion outcomes have driven motivation for more sophisticated and multidisciplinary solutions, involving new biomaterials and/or biologics, through innovative delivery platforms...
May 17, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28513514/efficacy-of-polishing-kits-on-the-surface-roughness-and-color-stability-of-different-composite-resins
#15
H Kocaagaoglu, T Aslan, A Gürbulak, H Albayrak, Z Taşdemir, H Gumus
OBJECTIVE: Different polishing kits may have different effects on the composite resin surfaces. The aim of this study was to evaluate the surface roughness and color stability of four different composites which was applied different polishing technique. MATERIALS AND METHODS: Thirty specimens were made for each composite resin group (nanohybrid, GrandioSo-GS; nanohybrid, Clearfil Majesty Esthetic-CME; hybrid, Valux Plus-VP; micro-hybrid, Ruby Comp-RC; [15 mm in diameter and 2 mm height]), with the different monomer composition and particle size from a total of 120 specimens...
May 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28507946/conditioned-medium-of-wharton-s-jelly-derived-stem-cells-can-enhance-the-cartilage-specific-genes-expression-by-chondrocytes-in-monolayer-and-mass-culture-systems
#16
Maryam Hassan Famian, Soheila Montazer Saheb, Azadeh Montaseri
Purpose: Mesenchymal stem cells (MSCs) have been introduced for cell therapy strategies in osteoarthritis (OA). Despite of their capacity for differentiation into chondrocyte, there are some evidences about their life-threatening problem after transplantation. So, some researchers shifted on the application of stem cells conditioned medium. The goal of this study is to evaluate whether Wharton's jelly derived stem cell conditioned medium (WJSCs-CM) can enhance the gene expression profile by chondrocytes in monolayer and mass culture systems...
April 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28505286/pixie-an-algorithm-for-automated-ion-mobility-arrival-time-extraction-and-collision-cross-section-calculation-using-global-data-association
#17
Jian Ma, Cameron P Casey, Xueyun Zheng, Yehia M Ibrahim, Christopher S Wilkins, Ryan S Renslow, Dennis G Thomas, Samuel H Payne, Matthew E Monroe, Richard D Smith, Justin G Teeguarden, Erin S Baker, Thomas O Metz
Motivation: Drift tube ion mobility spectrometry coupled with mass spectrometry (DTIMS-MS) is increasingly implemented in high throughput omics workflows, and new informatics approaches are necessary for processing the associated data. To automatically extract arrival times for molecules measured by DTIMS at multiple electric fields and compute their associated collisional cross sections (CCS), we created the PNNL Ion Mobility Cross Section Extractor (PIXiE). The primary application presented for this algorithm is the extraction of data that can then be used to create a reference library of experimental CCS values for use in high throughput omics analyses...
May 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28499502/sesamin-encouraging-effects-on-chondrogenic-differentiation-of-human-amniotic-fluid-derived-mesenchymal-stem-cells
#18
Suteera Narakornsak, Sirinda Aungsuchawan, Peeraphan Pothacharoen, Runchana Markmee, Waleephan Tancharoen, Tanongsak Laowanitwattana, Chawapon Thaojamnong, Lamaiporn Peerapapong, Nonglak Boonma, Witoon Tasuya, Junjira Keawdee, Naree Poovachiranon
Worldwide, the most recognized musculoskeletal degenerative disease is osteoarthritis (OA). Sesamin, a major abundant lignan compound present in Sesamun Indicum Linn, has been described for its various pharmacological effects and health benefits. However, the promoting effects of sesamin on chondrogenic differentiation have not yet been observed. Herein, the aim of this study was to investigate the effects of sesamin on cell cytotoxicity and the potent supporting effects on chondrogenic differentiation of human amniotic fluid-derived mesenchymal stem cells (hAF-MSCs)...
May 9, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28498950/igess-a-statistical-approach-to-integrating-individual-level-genotype-data-and-summary-statistics-in-genome-wide-association-studies
#19
Mingwei Dai, Jingsi Ming, Mingxuan Cai, Jin Liu, Can Yang, Xiang Wan, Zongben Xu
Motivation: Results from genome-wide association studies (GWAS) suggest that a complex phenotype is often affected by many variants with small effects, known as "polygenicity". Tens of thousands of samples are often required to ensure statistical power of identifying these variants with small effects. However, it is often the case that a research group can only get approval for the access to individual-level genotype data with a limited sample size (e.g., a few hundreds or thousands)...
May 11, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28491082/altered-serum-level-of-cartilage-oligomeric-matrix-protein-and-its-association-with-coronary-calcification-in-patients-with-coronary-heart-disease
#20
Fang-Fang Wang, Lahati Ha, Hai-Yi Yu, Lin Mi, Jiang-Li Han, Wei Gao
BACKGROUND: Cartilage oligomeric matrix protein (COMP) is mainly found in the skeletal system and vascular smooth muscle cells. Recent researches showed that it had a protective function on blood vessels and could also inhibit vascular calcification. We investigated the serum COMPs in coronary heart disease (CHD) patients, and the relationship between serum COMP and the calcification of coronary artery. METHODS: A total of 233 consecutive chest pain patients who first underwent coronary angiography followed by multi-slice computed tomography (MSCT) within six months were recruited and divided into two groups according to the coronary angiography luminal diameter narrowing percentages: CHD group (diameter narrowing ≥ 50%, n = 194) and control group (diameter narrowing < 50%, n = 39)...
February 2017: Journal of Geriatric Cardiology: JGC
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