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https://www.readbyqxmd.com/read/27911880/study-of-the-sign-change-of-exchange-bias-across-the-spin-reorientation-transition-in-co-cr1-x-fe-x-2o4-x%C3%A2-%C3%A2-%C3%A2-%C3%A2-0-00-0-125
#1
R Padam, Swati Pandya, S Ravi, S Ramakrishnan, A K Nigam, A K Grover, D Pal
We present the evolution of novel phenomena of magnetic compensation effect, exchange bias (EB) effect and the field induced anomalies in '[Formula: see text]' substituted multiferroic compound [Formula: see text]. A few percent of '[Formula: see text]' substitution for '[Formula: see text]' in [Formula: see text] results in the reversal of field cooled magnetization under low applied fields below compensation temperature T comp. Further, increase in the field leads to the spin reorientation transition (T SR)...
December 2, 2016: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/27899062/scleraxis-is-essential-for-tendon-differentiation-by-equine-embryonic-stem-cells-and-in-equine-fetal-tenocytes
#2
Emma Bavin, Francesca Atkinson, Tom Barsby, Debbie Guest
The transcription factor scleraxis is required for tendon development and is upregulated during embryonic stem cell (ESC) differentiation into tenocytes. However, its role beyond early embryonic development is not defined. We utilised a short hairpin RNA to knockdown scleraxis expression in ESCs, adult and fetal tenocytes. No effect on growth or morphology was observed in 2D cultures. However, scleraxis knockdown in fetal tenocytes significantly reduced COL1A1, COMP and SOX9 gene expression. Scleraxis knockdown in adult tenocytes had no effect on the expression of these genes...
November 29, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/27884646/microrna-92a-3p-regulates-the-expression-of-cartilage-specific-genes-by-directly-targeting-histone-deacetylase-2-in-chondrogenesis-and-degradation
#3
Guping Mao, Ziji Zhang, Zhiyu Huang, Weishen Chen, Guangxin Huang, Fangang Meng, Zhiqi Zhang, Yan Kang
OBJECTIVE: Increased activity of histone deacetylase 2 (HDAC2) has been found in patients with osteoarthritis (OA) and cartilage matrix degradation and has been shown to mediate the repression of cartilage-specific gene expression in human chondrocytes. We aimed to determine whether microRNA-92a-3p (miR-92a-3p) regulates cartilage-specific gene expression via targeted HDAC2 in chondrogenesis and degradation. METHODS: miR-92a-3p expression was assessed in vitro in a human mesenchymal stem cells (hMSCs) model of chondrogenesis and in normal and OA primary human chondrocytes (PHCs), and in normal and OA human cartilage by in situ hybridization...
November 21, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27876074/combined-detection-of-serum-ctx-ii-and-comp-concentrations-in-osteoarthritis-model-rabbits-an-effective-technique-for-early-diagnosis-and-estimation-of-disease-severity
#4
Bin Bai, Yanqin Li
BACKGROUND: Early diagnosis of osteoarthritis (OA) is difficult. Cartilage oligomeric matrix protein (COMP) and crosslinked C-telopeptides of type II collagen (CTX-II) are two markers which can potentially predict the destruction of articular cartilage of early OA. To comprehensively evaluate the diagnosis value of serum COMP and CTX-II markers in OA, the longitudinal and combined measurement of serum COMP and CTX-II were performed at different stages of pathological process of OA in adult rabbits with OA, compared with the sham-operated rabbits...
November 22, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27846748/beneficial-effects-of-natural-eggshell-membrane-nem-on-multiple-indices-of-arthritis-in-collagen-induced-arthritic-rats
#5
Karen J Wedekind, Kevin J Ruff, Cindy A Atwell, Joseph L Evans, Alison M Bendele
OBJECTIVES: This study was performed to evaluate the potential efficacy of natural eggshell membrane (NEM) in collagen-induced arthritic rats, a well-established rodent model of inflammation and rheumatoid arthritis. METHODS: Rats with developing type II collagen-induced arthritis (CIA) were treated once daily by oral gavage on study days -14 to 17 with vehicle or NEM (52 mg/kg body weight). Rats were euthanized on study day 17. Efficacy was assessed by daily ankle caliper measurements, ankle diameter expressed as area under the curve (AUCd0-17), and histopathologic evaluation of ankles and knees...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27845939/multiscale-and-multimodality-computed-tomography-for-cortical-bone-analysis
#6
A Ostertag, F Peyrin, P J Gouttenoire, J D Laredo, M C DeVernejoul, M Cohen Solal, C Chappard
In clinical studies, high resolution peripheral quantitative computed tomography (HR-pQCT) is used to separately evaluate cortical bone and trabecular bone with an isotropic voxel of 82 µm(3), and typical cortical parameters are cortical density (D.comp), thickness (Ct.Th), and porosity (Ct.Po). In vitro, micro-computed tomography (micro-CT) is used to explore the internal cortical bone micro-structure with isotropic voxels and high resolution synchrotron radiation (SR); micro-CT is considered the 'gold standard'...
December 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27821120/pro-inflammatory-cytokines-and-structural-biomarkers-are-effective-to-categorize-osteoarthritis-phenotype-and-progression-in-standardbred-racehorses-over-five-years-of-racing-career
#7
Andrea Bertuglia, Eleonora Pagliara, Elena Grego, Alessandro Ricci, Nika Brkljaca-Bottegaro
BACKGROUND: Joint impact injuries initiate a progressive articular damage finally leading to post-traumatic osteoarthritis (PTOA). Racehorses represent an ideal, naturally available, animal model of the disease. Standardbred racehorses developing traumatic osteoarthritis of the fetlock joint during the first year of their career were enrolled in our study. Age-matched controls were contemporarily included. Biomarker levels of equine osteoarthritis were measured in serum and synovial fluid (SF) at baseline, and repeated yearly over the next 4 years of training (from T1 to T4)...
November 8, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27818488/identi%C3%AF-cation-of-differentially-expressed-genes-in-pelvic-organ-prolapse-by-rna-seq
#8
Ruoyun Xie, Ying Xu, Shuixiu Fan, Yanfeng Song
BACKGROUND Pelvic organ prolapse (POP) brings major health issues for women, affecting 40% of postmenopausal women, and directly affects bladder and bowel function, as well as quality of life. In light of the projected growth in demand for care for pelvic floor disorders, determining the etiology and progression of POP has important public health implications. MATERIAL AND METHODS Uterosacral ligaments (USLs) samples of POP patients and normal controls were enrolled for RNA-Seq, and functional annotation analysis and Protein-Protein interaction (PPI) networks construction were performed for differentially expressed genes (DEGs)...
November 7, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27813662/matrix-metalloproteinase-activity-and-prostaglandin-e2-are-elevated-in-the-synovial-fluid-of-meniscus-tear-patients
#9
Betty Liu, Adam P Goode, Teralyn E Carter, Gangadhar M Utturkar, Janet L Huebner, Dean C Taylor, Claude T Moorman Iii, William E Garrett, Virginia B Kraus, Farshid Guilak, Louis E DeFrate, Amy L McNulty
PURPOSE: Meniscus tears are a common knee injury and are associated with the development of post-traumatic osteoarthritis (OA). The purpose of this study was to evaluate potential OA mediators in the synovial fluid and serum of meniscus tear subjects compared to those in the synovial fluid of radiographic non-OA control knees. MATERIALS AND METHODS: Sixteen subjects with an isolated unilateral meniscus injury and six subjects who served as reference controls (knee Kellgren-Lawrence grade 0-1) were recruited...
November 4, 2016: Connective Tissue Research
https://www.readbyqxmd.com/read/27810435/candidate-methylated-genes-in-osteoarthritis-explored-by-bioinformatics-analysis
#10
Jie Liu, Yangquan Hao, Yugui Wang, Shouye Hu, Ke Xu, Chao Lu
BACKGROUND: This study aimed to explore potential novel genes correlated with osteoarthritis (OA). METHODS: The gene expression profile of GSE48422 was downloaded from the Gene Expression Omnibus (GEO) database. This dataset included five arthritic cartilage samples and five non-arthritic cartilage samples from five female OA patients. Differentially methylated genes (DMGs) between the two kinds of samples were identified, followed by their functional analysis and protein-protein interaction (PPI) analysis...
October 31, 2016: Knee
https://www.readbyqxmd.com/read/27802241/modulation-of-parkinson-s-disease-associated-protein-rescues-alzheimer-s-disease-degeneration
#11
Akihiko Nunomura, Xiongwei Zhu, George Perry
DJ-1, a causative gene product of an autosomal recessive familial form of Parkinson's disease (PD), plays roles in reducing oxidative stress and transcriptional regulation. Loss of its function is thought to result in the onset of PD. DJ-1 has been demonstrated to show general cytoprotective function mainly through antioxidant properties and possibly regulates the extent of stroke-induced damage and neurodegeneration in Alzheimer's disease (AD). The paper, "Effects of a DJ-1-Binding Compound on Spatial Learning and Memory Impairment in a Mouse Model of Alzheimer's Disease", by Kitamura et al...
October 12, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27779540/satisfaction-data-collected-by-e-mail-and-smartphone-for-emergency-department-patients-how-do-responders-compare-with-nonresponders
#12
Jeffery C Strickler, Kenneth K Lopiano
OBJECTIVE: This study profiles an innovative approach to capture patient satisfaction data from emergency department (ED) patients by implementing an electronic survey method. This study compares responders to nonresponders. BACKGROUND: Our hypothesis is that the cohort of survey respondents will be similar to nonresponders in terms of the key characteristics of age, gender, race, ethnicity, ED disposition, and payor status. METHODS: This study is a cross-sectional design using secondary data from the database and provides an opportunity for univariate analysis of the key characteristics for each group...
November 2016: Journal of Nursing Administration
https://www.readbyqxmd.com/read/27749237/mri-and-serum-biomarkers-correlate-with-radiographic-features-in-painful-hand-osteoarthritis
#13
Christian H Roux, Violaine Foltz, Emmanuel Maheu, Gabriel Baron, Frederique Gandjbakhch, Cédric Lukas, Daniel Wendling, Damien Loeuille, Pierre Lafforgue, Liana Euler-Ziegler, Pascal Richette, Xavier Chevalier
OBJECTIVES: To explore the relationship between clinical findings, biologic biomarkers, conventional radiography and MRI in patients with painful hand OA. METHODS: The following patient baseline data from the DORA study (evaluating anti-TNF-α agents against painful hand OA) were used: clinical assessment (pain, swelling, stiffness and function: Dreiser functional hand index [FIHOA] and Cochin hand functional scale [CHFS]); measurement of biomarkers (cartilage oligomeric matrix protein (COMP), type IIA collagen N-propeptid (PIINP), hyaluronic acid (HA), ultrasensitive C-reactive protein (usCRP), tumour necrosis factor (TNF), interleukin (IL)-6, IL-1β and urinary CTXII); radiological staging (Verbruggen, Kallman, Kellgren-Lawrence); anatomical evaluation by contrast-enhanced MRI of proximal and distal interphalangeal joints of dominant hand...
September 18, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27699484/running-decreases-knee-intra-articular-cytokine-and-cartilage-oligomeric-matrix-concentrations-a-pilot-study
#14
Robert D Hyldahl, Alyssa Evans, Sunku Kwon, Sarah T Ridge, Eric Robinson, J Ty Hopkins, Matthew K Seeley
INTRODUCTION: Regular exercise protects against degenerative joint disorders, yet the mechanisms that underlie these benefits are poorly understood. Chronic, low-grade inflammation is widely implicated in the onset and progression of degenerative joint disease. PURPOSE: To examine the effect of running on knee intra-articular and circulating markers of inflammation and cartilage turnover in healthy men and women. METHODS: Six recreational runners completed a running (30 min) and control (unloaded for 30 min) session in a counterbalanced order...
October 3, 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27697946/estimating-cigarette-tax-avoidance-and-evasion-evidence-from-a-national-sample-of-littered-packs
#15
Dianne C Barker, Shu Wang, David Merriman, Andrew Crosby, Elissa A Resnick, Frank J Chaloupka
INTRODUCTION: A number of recent studies document the proportion of all cigarette packs that are 'contraband' using discarded packs to measure tax avoidance and evasion, which we call tax non-compliance. To date, academic studies using discarded packs focused on relatively small geographical areas such as a city or a neighbourhood. METHODS: We visited 160 communities across 38 US states in 2012 and collected data from littered cigarette packs as part of the State and Community Tobacco Control (SCTC) Research Initiative and the Bridging the Gap Community Obesity Measures Project (BTG-COMP)...
October 2016: Tobacco Control
https://www.readbyqxmd.com/read/27693578/the-e3-ubiquitin-ligase-c-cbl-mediates-integrin-%C3%AE-1-ubiquitination-during-dilated-cardiomyopathy
#16
Nan Yang, Fang Yu, Genze Shao, Yi Fu, Wei Kong
Dilated cardiomyopathy (DCM) is characterized by dilatation of the ventricular chambers and impaired myocardial contractility. The results of our previous study indicated that a deficiency in matricellular cartilage oligomeric matrix protein (COMP) led to spontaneous and progressive DCM in mice via the ubiquitination/degradation of integrin β1. However, the specific ubiquitin enzyme involved in degradation of integrin β1 and the pathogenesis of DCM remain elusive. We first compared gene expression profiles in hearts from 3-month-old wild type and COMP(-/-) mice using microarray analysis...
October 28, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27685144/canadian-partnership-for-quality-radiotherapy-cpqr-and-the-canadian-organization-of-medical-physicists-comp-driving-safety-and-quality-assurance-practice-in-canada-through-the-development-of-technical-quality-control-guidelines
#17
Jean-Pierre Bissonnette, Michael Milosevic, Marco Carlone, Kyle E Malkoske
No abstract text is available yet for this article.
2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27667270/-comparison-on-metabolic-disorders-and-uric-acid-levels-between-patients-with-primary-aldosteronism-and-essential-hypertension
#18
Y J Deng, S L Zhang, P M Liu, L F Mai, J Y Tang, L Yan
Objective: To compare the incidence of metabolic disorders and uric acid (UA) levels between patients with primary aldosteronism (PA) and essential hypertension (EH), and to explore factors associated with UA levels in these patients. Methods: A total of 117 PA and 117 EH patients individually matched by sex, age, blood pressure and duration of hypertension were recruited from in-hospital patients who were hospitalized in our department because of suspicion of secondary hypertension from January 2008 to December 2014...
September 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/27662308/effects-of-a-dj-1-binding-compound-on-spatial-learning-and-memory-impairment-in-a-mouse-model-of-alzheimer-s-disease
#19
Yoshihisa Kitamura, Masatoshi Inden, Yasuto Kimoto, Kazuyuki Takata, Daijiro Yanagisawa, Masanori Hijioka, Eishi Ashihara, Ikuo Tooyama, Shun Shimohama, Hiroyoshi Ariga
Previously, DJ-1 modulator UCP0054278/comp-B was identified by virtual screening, where comp-B interacts with DJ-1 to produce antioxidant and neuroprotective responses in Parkinson's disease models. However, the effect of comp-B in an in vivo Alzheimer's disease (AD) model is yet undetermined. Thus, we examined the effect of comp-B on spatial learning, memory, and amyloid-β (Aβ) clearance in a transgenic mouse model of AD. We found that comp-B resolved the cognitive deficits, reduced insoluble Aβ42 levels, and prevented the degeneration of synaptic functions, thereby suggesting that comp-B may become a major compound for AD treatment...
September 21, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27634599/tnf-%C3%AE-concentrations-in-pre-operative-synovial-fluid-for-predicting-early-post-operative-function-and-pain-after-fast-track-total-knee-arthroplasty
#20
Pawel Zietek, Violetta Dziedziejko, Krzysztof Safranow, Joanna Zietek, Marta Stępień-Słodkowska, Monika Bialecka, Maciej Zietek, Daniel Kotrych, Adam Kamiński, Aleksandra Kowalska
BACKGROUND: Tumor necrosis factor-alpha (TNF-α) helps regulate neuroinflammation and anxiety and could conceivable predict early post-operative pain and function after fast-track total knee arthroplasty (TKA). METHODS: In patients with severe osteoarthritic knees undergoing TKA, we assessed: the correlations between pre-operative concentrations of TNF-α in synovial fluid; pre- and six-week post-operative knee function and pain; pre- and post-operative anxiety; pre- and post-operative synovial fluid concentrations of cartilage oligomeric matrix protein (COMP); age and body mass index (BMI)...
September 12, 2016: Knee
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