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Christian H Roux, Violaine Foltz, Emmanuel Maheu, Gabriel Baron, Frederique Gandjbakhch, Cédric Lukas, Daniel Wendling, Damien Loeuille, Pierre Lafforgue, Liana Euler-Ziegler, Pascal Richette, Xavier Chevalier
OBJECTIVES: To explore the relationship between clinical findings, biologic biomarkers, conventional radiography and MRI in patients with painful hand OA. METHODS: The following patient baseline data from the DORA study (evaluating anti-TNF-α agents against painful hand OA) were used: clinical assessment (pain, swelling, stiffness and function: Dreiser functional hand index [FIHOA] and Cochin hand functional scale [CHFS]); measurement of biomarkers (cartilage oligomeric matrix protein (COMP), type IIA collagen N-propeptid (PIINP), hyaluronic acid (HA), ultrasensitive C-reactive protein (usCRP), tumour necrosis factor (TNF), interleukin (IL)-6, IL-1β and urinary CTXII); radiological staging (Verbruggen, Kallman, Kellgren-Lawrence); anatomical evaluation by contrast-enhanced MRI of proximal and distal interphalangeal joints of dominant hand...
September 18, 2016: Clinical and Experimental Rheumatology
Robert D Hyldahl, Alyssa Evans, Sunku Kwon, Sarah T Ridge, Eric Robinson, J Ty Hopkins, Matthew K Seeley
INTRODUCTION: Regular exercise protects against degenerative joint disorders, yet the mechanisms that underlie these benefits are poorly understood. Chronic, low-grade inflammation is widely implicated in the onset and progression of degenerative joint disease. PURPOSE: To examine the effect of running on knee intra-articular and circulating markers of inflammation and cartilage turnover in healthy men and women. METHODS: Six recreational runners completed a running (30 min) and control (unloaded for 30 min) session in a counterbalanced order...
October 3, 2016: European Journal of Applied Physiology
Dianne C Barker, Shu Wang, David Merriman, Andrew Crosby, Elissa A Resnick, Frank J Chaloupka
INTRODUCTION: A number of recent studies document the proportion of all cigarette packs that are 'contraband' using discarded packs to measure tax avoidance and evasion, which we call tax non-compliance. To date, academic studies using discarded packs focused on relatively small geographical areas such as a city or a neighbourhood. METHODS: We visited 160 communities across 38 US states in 2012 and collected data from littered cigarette packs as part of the State and Community Tobacco Control (SCTC) Research Initiative and the Bridging the Gap Community Obesity Measures Project (BTG-COMP)...
October 2016: Tobacco Control
Nan Yang, Fang Yu, Genze Shao, Yi Fu, Wei Kong
Dilated cardiomyopathy (DCM) is characterized by dilatation of the ventricular chambers and impaired myocardial contractility. The results of our previous study indicated that a deficiency in matricellular cartilage oligomeric matrix protein (COMP) led to spontaneous and progressive DCM in mice via the ubiquitination/degradation of integrin β1. However, the specific ubiquitin enzyme involved in degradation of integrin β1 and the pathogenesis of DCM remain elusive. We first compared gene expression profiles in hearts from 3-month-old wild type and COMP(-/-) mice using microarray analysis...
October 28, 2016: Biochemical and Biophysical Research Communications
Jean-Pierre Bissonnette, Michael Milosevic, Marco Carlone, Kyle E Malkoske
No abstract text is available yet for this article.
2016: Journal of Applied Clinical Medical Physics
Y J Deng, S L Zhang, P M Liu, L F Mai, J Y Tang, L Yan
Objective: To compare the incidence of metabolic disorders and uric acid (UA) levels between patients with primary aldosteronism (PA) and essential hypertension (EH), and to explore factors associated with UA levels in these patients. Methods: A total of 117 PA and 117 EH patients individually matched by sex, age, blood pressure and duration of hypertension were recruited from in-hospital patients who were hospitalized in our department because of suspicion of secondary hypertension from January 2008 to December 2014...
September 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
Yoshihisa Kitamura, Masatoshi Inden, Yasuto Kimoto, Kazuyuki Takata, Daijiro Yanagisawa, Masanori Hijioka, Eishi Ashihara, Ikuo Tooyama, Shun Shimohama, Hiroyoshi Ariga
Previously, DJ-1 modulator UCP0054278/comp-B was identified by virtual screening, where comp-B interacts with DJ-1 to produce antioxidant and neuroprotective responses in Parkinson's disease models. However, the effect of comp-B in an in vivo Alzheimer's disease (AD) model is yet undetermined. Thus, we examined the effect of comp-B on spatial learning, memory, and amyloid-β (Aβ) clearance in a transgenic mouse model of AD. We found that comp-B resolved the cognitive deficits, reduced insoluble Aβ42 levels, and prevented the degeneration of synaptic functions, thereby suggesting that comp-B may become a major compound for AD treatment...
September 21, 2016: Journal of Alzheimer's Disease: JAD
Pawel Zietek, Violetta Dziedziejko, Krzysztof Safranow, Joanna Zietek, Marta Stępień-Słodkowska, Monika Bialecka, Maciej Zietek, Daniel Kotrych, Adam Kamiński, Aleksandra Kowalska
BACKGROUND: Tumor necrosis factor-alpha (TNF-α) helps regulate neuroinflammation and anxiety and could conceivable predict early post-operative pain and function after fast-track total knee arthroplasty (TKA). METHODS: In patients with severe osteoarthritic knees undergoing TKA, we assessed: the correlations between pre-operative concentrations of TNF-α in synovial fluid; pre- and six-week post-operative knee function and pain; pre- and post-operative anxiety; pre- and post-operative synovial fluid concentrations of cartilage oligomeric matrix protein (COMP); age and body mass index (BMI)...
September 12, 2016: Knee
Rani Mansuri, Md Yousuf Ansari, Sindhuprava Rana, Jagbir Singh, Sahil Sinha, Manas Ranjan Dikhit, Ganesh Chandra Sahoo, Pradeep Das
Glucose-1-Phosphate Thymidylyltransferase (RmlA) is one of the enzymes in rhamnose biosynthesis pathway, where rhamnose act as linker of peptidoglycan and arabinogalacton in the cell wall, therefore RmlA is a potential enzyme for the survival of Mycobacterium tuberculosis (Mtb). To go into the depth of the structure for exploring binding regions, homology model of RmlA was built in Prime, Schrodinger v9.2. The model with lowest Discrete Optimized Potential Energy (DOPE) score of -35524.17 kcal/mol and RMSD of 0...
September 9, 2016: Current Pharmaceutical Biotechnology
Ned Brophy-Williams, Matthew W Driller, Cecilia M Kitic, James W Fell, Shona L Halson
PURPOSE: To determine the effect of wearing compression socks between repeated running bouts on perceptual, physiological and performance-based parameters. METHODS: Twelve well-trained male runners (mean ± SD; 5km time 19:24 ± 1:19 mm:ss) recorded their perceptions on the efficacy of compression socks for recovery prior to completion of two experimental sessions. Each session consisted of two 5km running time trials (TT1 and TT2) on a treadmill, with a one-hour recovery period between each TT...
September 15, 2016: International Journal of Sports Physiology and Performance
Gema Santamaría Nuñez, Carlos Mario Genes Robles, Christophe Giraudon, Juan Fernando Martínez-Leal, Emmanuel Compe, Frédéric Coin, Pablo Aviles, Carlos María Galmarini, Jean-Marc Egly
We have defined the mechanism of action of lurbinectedin, a marine-derived drug exhibiting a potent antitumor activity across several cancer cell lines and tumor xenografts. This drug, currently undergoing clinical evaluation in ovarian, breast, and small cell lung cancer patients, inhibits the transcription process through (i) its binding to CG-rich sequences, mainly located around promoters of protein-coding genes; (ii) the irreversible stalling of elongating RNA polymerase II (Pol II) on the DNA template and its specific degradation by the ubiquitin/proteasome machinery; and (iii) the generation of DNA breaks and subsequent apoptosis...
October 2016: Molecular Cancer Therapeutics
Abed Zadehgol
In this work, a generalized form of the BGK-Boltzmann equation is proposed, where the velocity, position, and time can be represented by real or complex variables. The real representation leads to the conventional BGK-Boltzmann equation, which can recover the continuity and Navier-Stokes equations. We show that the complex representation yields a different set of equations, and it can also recover the conservation and Navier-Stokes equations, at low Mach numbers, provided that the imaginary component of the macroscopic mass can be neglected...
August 2016: Physical Review. E
Kai Dong, Hongyu Zhao, Tiejun Tong, Xiang Wan
BACKGROUND: RNA-sequencing (RNA-Seq) has become a powerful technology to characterize gene expression profiles because it is more accurate and comprehensive than microarrays. Although statistical methods that have been developed for microarray data can be applied to RNA-Seq data, they are not ideal due to the discrete nature of RNA-Seq data. The Poisson distribution and negative binomial distribution are commonly used to model count data. Recently, Witten (Annals Appl Stat 5:2493-2518, 2011) proposed a Poisson linear discriminant analysis for RNA-Seq data...
2016: BMC Bioinformatics
Govinda Bhattarai, Sung-Ho Kook, Jae-Hwan Kim, Sher Bahadur Poudel, Shin-Saeng Lim, Young-Kwon Seo, Jeong-Chae Lee
COMP-Ang1, a chimera of angiopoietin-1 (Ang1) and a short coiled-coil domain of cartilage oligomeric matrix protein (COMP), is under consideration as a therapeutic agent enhancing tissue regeneration with increased angiogenesis. However, the effect of COMP-Ang1 on periodontitic tissue damages and the related mechanisms are not yet investigated. We initially explored whether a local delivery of COMP-Ang1 protects lipopolysaccharide (LPS)/ligature-induced periodontal destruction in rats. As the results, μCT and histological analyses revealed that COMP-Ang1 inhibits LPS-mediated degradation of periodontium...
November 2016: Bone
Marta Vales Montero, Beatriz Chavarría Cano, María Luisa Martínez Ginés, Fernando Díaz Otero, José Miguel Velázquez Pérez, María Cristina Cuerda Compes, Irene Bretón Lesmes
La deficiencia de vitamina A es infrecuente en los países desarrollados. La cirugía bariátrica constituye un factor de riesgo de deficiencia de esta vitamina. Se han descrito varios casos en pacientes sometidos a técnicas con un importante componente malabsortivo, como la derivación biliopancreática. En este artículo se describe un caso de deficiencia clínica de vitamina A con manifestaciones oculares y cutáneas tras bypass gástrico y se revisan las publicaciones sobre este tema y las recomendaciones para la prevención de esta importante complicación...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Rosa Burgos Peláez, María Cristina Cuerda Compes, Pedro P García-Luna, Ceferino Martínez Faedo, Sílvia Mauri Roca, José Manuel Moreno Villares, M Nuria Virgili Casas, Carmina Wanden-Berghe
Introducción:la nutrición parenteral (NP) a largo plazo puede asociarse a complicaciones graves, con un deterioro importante de la calidad de vida de los pacientes con síndrome de intestino corto (SIC). Teduglutida, un análogo del péptido-2 similar al glucagón, pertenece a una nueva familia terapéutica y representa el primer abordaje no sintomático del SIC. Objetivos: revisar los datos preclínicos y clínicos en cuanto a eficacia y seguridad de teduglutida. Resultados: la aprobación de teduglutida se basó en los resultados de un estudio en fase III de 24 semanas, doble ciego, controlado con placebo (STEPS)...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
See-Hyoung Park, Jongsung Lee, Mi-Ae Kang, Young Jae Moon, Sung Il Wang, Kyoung Min Kim, Byung-Hyun Park, Kyu Yun Jang, Jung Ryul Kim
Angiogenesis is closely associated with osteoblast differentiation. Previously, we demonstrated that bone formation can be accelerated by treatment with COMP-Angiopoietin1, a known angiogenic factor. Angiopoietin1 (Ang1) is a specific growth factor that generates stable and mature vasculature through the Tie2 receptor. In this study, we aimed to identify a novel drug that can activate endogenous Ang1 expression as a pharmacological treatment for bone formation. Therefore, Ang1 expression was examined in U2OS osteoblast-like cells treated with 770 drugs from a library of Food and Drug Administration (FDA)-approved drugs by using ELISA for Ang1...
September 23, 2016: Biochemical and Biophysical Research Communications
D A Sandercock, S H Smith, P Di Giminiani, S A Edwards
No abstract text is available yet for this article.
August 23, 2016: Journal of Comparative Pathology
Biswajit Dalal, Babusona Sarkar, Vishal Dev Ashok, S K De
Magnetic properties of YbCr1-x Ru x O3 as a function of temperature and magnetic field have been investigated to explore the intriguing magnetic phenomena in rare-earth orthochromites. A quantitative analysis of x-ray photoelectron spectroscopy confirms the mixed valence state (Yb(3+) and Yb(2+)) of Yb ions for the highest doped sample. Field-cooled magnetization reveals a broad peak around 75 K and then becomes zero at about 20-24 K, due to the antiparallel coupling between Cr(3+) and Yb(3+) moments. An increase of the Ru(4+) ion concentration leads to a slight increase of compensation temperature T comp from 20 to 24 K, but the Néel temperature remains constant...
October 26, 2016: Journal of Physics. Condensed Matter: An Institute of Physics Journal
A V Perruccio, V Chandran, J D Power, M Kapoor, N N Mahomed, R Gandhi
OBJECTIVE: We investigated the association between serum levels of C-reactive protein (CRP) and the extent of multijoint pain among individuals with hip/knee osteoarthritis (OA) and determined whether the association differs by sex. DESIGN: Serum CRP and cartilage oligomeric matrix protein (COMP) were determined by enzyme-linked immunosorbent assay (ELISA) in 189 individuals (101 female, 88 male) scheduled for total hip/knee arthroplasty for OA. Patients indicated on a homunculus all painful joints; a summed count was derived...
August 19, 2016: Osteoarthritis and Cartilage
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