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https://www.readbyqxmd.com/read/28542244/a-quantitative-label-free-analysis-of-the-extracellular-proteome-of-human-supraspinatus-tendon-reveals-damage-to-the-pericellular-and-elastic-fibre-niches-in-torn-and-aged-tissue
#1
Osnat Hakimi, Nicola Ternette, Richard Murphy, Benedikt M Kessler, Andrew Carr
Tears of the human supraspinatus tendon are common and often cause painful and debilitating loss of function. Progressive failure of the tendon leading to structural abnormality and tearing is accompanied by numerous cellular and extra-cellular matrix (ECM) changes in the tendon tissue. This proteomics study aimed to compare torn and aged rotator cuff tissue to young and healthy tissue, and provide the first ECM inventory of human supraspinatus tendon generated using label-free quantitative LC-MS/MS. Employing two digestion protocols (trypsin and elastase), we analysed grain-sized tendon supraspinatus biopsies from older patients with torn tendons and from healthy, young controls...
2017: PloS One
https://www.readbyqxmd.com/read/28536825/intramuscular-clodronate-in-erosive-osteoarthritis-of-the-hand-is-effective-on-pain-and-reduces-serum-comp-a-randomized-pilot-trial-the-er-o-d-e-study-erosive-osteoarthritis-and-disodium-clodronate-evaluation
#2
Gianantonio Saviola, Lul Abdi-Ali, Maria Rosaria Povino, Lorella Campostrini, Silvano Sacco, Luca Dalle Carbonare
We evaluated the efficacy and safety of intramuscular clodronate (CLO) for the treatment of active erosive osteoarthritis of the hand (EOA). Forty outpatients treated with anti-inflammatory (NSAIDs) or analgesic drugs since at least 6 months, for at least 3 days a week, were randomly divided into two groups. Group A: 24 patients treated for 6 months with intramuscular (i.m.) CLO added to usual NSAIDs or analgesic drugs. The attack dose was 200 mg/day i.m. for 10 days followed by a maintenance dose of CLO i...
May 23, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28525322/a-systemic-review-of-existing-serological-possibilities-to-diagnose-canine-osteoarthritis-with-a-particular-focus-on-extracellular-matrix-proteoglycans-and-protein
#3
M Shahid, G Manchi, P Slunsky, O Naseer, A Fatima, B Leo, J Raila
Extra-cellular matrix (ECM) components are important and their stabilization is significant in maintaining normal healthy joint environment. In osteoarthritis (OA), ECM components are altered and indicate disease progression. The joint ECM is composed of proteoglycans (aggrecan, perlecan, inter α-trypsin inhibitor), glycoproteins (fibronectin, lubricin, COMP) and collagen types (most abundantly collagen type II) which represent structural and functional transformation during disease advancement. ECM investigation revealed significant biomarkers of OA that could be used as a diagnostic and therapeutic tool in different canine orthopedic diseases...
March 28, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28524259/nonpegylated-liposomal-doxorubicin-combination-regimen-in-patients-with-diffuse-large-b-cell-lymphoma-and-cardiac-comorbidity-results-of-the-heart01-phase-ii-trial-conducted-by-the-fondazione-italiana-linfomi
#4
Stefano Luminari, Elda Viel, Andrés José Maria Ferreri, Francesco Zaja, Emanuela Chimienti, Gerardo Musuraca, Alessandra Tucci, Monica Balzarotti, Monica Tani, Francesca Salvi, Emanuela A Pesce, Angela Ferrari, Anna M Liberati, Antonio Spadea, Dario Marino, Maria Bruno-Ventre, Stefano Volpetti, Chiara Bottelli, Elena Ravaioli, Francesco Merli, Michele Spina
The purpose of this phase 2, multicenter study was to determine the activity and safety of nonpegylated liposomal doxorubicin as part of "R-COMP" combination in patients with diffuse large B-cell lymphoma and coexisting cardiac disorders. The study was conducted using a Bayesian continuing assessment method using complete remission rate and rate of cardiac events as study endpoints. Between November 2009 and October 2011, 50 evaluable patients were enrolled (median age, 76 years). Median baseline left ventricular ejection fraction (LVEF) was 60%...
May 19, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28522284/corrigendum-to-development-of-a-new-pcr-based-assay-to-detect-anaplasmataceae-and-the-first-report-of-anaplasma-phagocytophilum-and-anaplasma-platys-in-cattle-from-algeria-comp-immunol-microbiol-infect-dis-4-39-2015-39-45-elsevier-ltd
#5
Mustapha Dahmani, Bernard Davoust, Mohamed Seghir Benterki, Florence Fenollar, Didier Raoult, Oleg Mediannikov
No abstract text is available yet for this article.
May 15, 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28514897/biomaterials-and-bioactive-agents-in-spinal-fusion
#6
Rui M Duarte, Pedro Varanda, Rui L Reis, Ana Rita C Duarte, Jorge Correia-Pinto
Management of degenerative spine pathologies frequently leads to the need for spinal fusion, where bone growth is induced towards stabilization of the interventioned spine. Autologous bone graft (ABG) remains the gold standard inducer, while new bone graft substitutes attempt to achieve effective de novo bone formation and solid fusion. Limited fusion outcomes have driven motivation for more sophisticated and multidisciplinary solutions, involving new biomaterials and/or biologics, through innovative delivery platforms...
May 17, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28513514/efficacy-of-polishing-kits-on-the-surface-roughness-and-color-stability-of-different-composite-resins
#7
H Kocaagaoglu, T Aslan, A Gürbulak, H Albayrak, Z Taşdemir, H Gumus
OBJECTIVE: Different polishing kits may have different effects on the composite resin surfaces. The aim of this study was to evaluate the surface roughness and color stability of four different composites which was applied different polishing technique. MATERIALS AND METHODS: Thirty specimens were made for each composite resin group (nanohybrid, GrandioSo-GS; nanohybrid, Clearfil Majesty Esthetic-CME; hybrid, Valux Plus-VP; micro-hybrid, Ruby Comp-RC; [15 mm in diameter and 2 mm height]), with the different monomer composition and particle size from a total of 120 specimens...
May 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28507946/conditioned-medium-of-wharton-s-jelly-derived-stem-cells-can-enhance-the-cartilage-specific-genes-expression-by-chondrocytes-in-monolayer-and-mass-culture-systems
#8
Maryam Hassan Famian, Soheila Montazer Saheb, Azadeh Montaseri
Purpose: Mesenchymal stem cells (MSCs) have been introduced for cell therapy strategies in osteoarthritis (OA). Despite of their capacity for differentiation into chondrocyte, there are some evidences about their life-threatening problem after transplantation. So, some researchers shifted on the application of stem cells conditioned medium. The goal of this study is to evaluate whether Wharton's jelly derived stem cell conditioned medium (WJSCs-CM) can enhance the gene expression profile by chondrocytes in monolayer and mass culture systems...
April 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28505286/pixie-an-algorithm-for-automated-ion-mobility-arrival-time-extraction-and-collision-cross-section-calculation-using-global-data-association
#9
Jian Ma, Cameron P Casey, Xueyun Zheng, Yehia M Ibrahim, Christopher S Wilkins, Ryan S Renslow, Dennis G Thomas, Samuel H Payne, Matthew E Monroe, Richard D Smith, Justin G Teeguarden, Erin S Baker, Thomas O Metz
Motivation: Drift tube ion mobility spectrometry coupled with mass spectrometry (DTIMS-MS) is increasingly implemented in high throughput omics workflows, and new informatics approaches are necessary for processing the associated data. To automatically extract arrival times for molecules measured by DTIMS at multiple electric fields and compute their associated collisional cross sections (CCS), we created the PNNL Ion Mobility Cross Section Extractor (PIXiE). The primary application presented for this algorithm is the extraction of data that can then be used to create a reference library of experimental CCS values for use in high throughput omics analyses...
May 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28499502/sesamin-encouraging-effects-on-chondrogenic-differentiation-of-human-amniotic-fluid-derived-mesenchymal-stem-cells
#10
Suteera Narakornsak, Sirinda Aungsuchawan, Peeraphan Pothacharoen, Runchana Markmee, Waleephan Tancharoen, Tanongsak Laowanitwattana, Chawapon Thaojamnong, Lamaiporn Peerapapong, Nonglak Boonma, Witoon Tasuya, Junjira Keawdee, Naree Poovachiranon
Worldwide, the most recognized musculoskeletal degenerative disease is osteoarthritis (OA). Sesamin, a major abundant lignan compound present in Sesamun Indicum Linn, has been described for its various pharmacological effects and health benefits. However, the promoting effects of sesamin on chondrogenic differentiation have not yet been observed. Herein, the aim of this study was to investigate the effects of sesamin on cell cytotoxicity and the potent supporting effects on chondrogenic differentiation of human amniotic fluid-derived mesenchymal stem cells (hAF-MSCs)...
May 9, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28498950/igess-a-statistical-approach-to-integrating-individual-level-genotype-data-and-summary-statistics-in-genome-wide-association-studies
#11
Mingwei Dai, Jingsi Ming, Mingxuan Cai, Jin Liu, Can Yang, Xiang Wan, Zongben Xu
Motivation: Results from genome-wide association studies (GWAS) suggest that a complex phenotype is often affected by many variants with small effects, known as "polygenicity". Tens of thousands of samples are often required to ensure statistical power of identifying these variants with small effects. However, it is often the case that a research group can only get approval for the access to individual-level genotype data with a limited sample size (e.g., a few hundreds or thousands)...
May 11, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28491082/altered-serum-level-of-cartilage-oligomeric-matrix-protein-and-its-association-with-coronary-calcification-in-patients-with-coronary-heart-disease
#12
Fang-Fang Wang, Lahati Ha, Hai-Yi Yu, Lin Mi, Jiang-Li Han, Wei Gao
BACKGROUND: Cartilage oligomeric matrix protein (COMP) is mainly found in the skeletal system and vascular smooth muscle cells. Recent researches showed that it had a protective function on blood vessels and could also inhibit vascular calcification. We investigated the serum COMPs in coronary heart disease (CHD) patients, and the relationship between serum COMP and the calcification of coronary artery. METHODS: A total of 233 consecutive chest pain patients who first underwent coronary angiography followed by multi-slice computed tomography (MSCT) within six months were recruited and divided into two groups according to the coronary angiography luminal diameter narrowing percentages: CHD group (diameter narrowing ≥ 50%, n = 194) and control group (diameter narrowing < 50%, n = 39)...
February 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28486666/cstea-a-webserver-for-the-cell-state-transition-expression-atlas
#13
Guanghui Zhu, Hui Yang, Xiao Chen, Jun Wu, Yong Zhang, Xing-Ming Zhao
Cell state transition is one of the fundamental events in the development of multicellular organisms, and the transition trajectory path has recently attracted much attention. With the accumulation of large amounts of "-omics" data, it is becoming possible to get insights into the molecule mechanisms underlying the transitions between cell states. Here, we present CSTEA (Cell State Transition Expression Atlas), a webserver that organizes, analyzes and visualizes the time-course gene expression data during cell differentiation, cellular reprogramming and trans-differentiation in human and mouse...
May 9, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28483486/corrigendum-to-characterization-of-molecular-properties-and-regulatory-pathways-of-crustinpm1-and-crustinpm7-from-the-black%C3%A2-tiger-shrimp-penaeus-monodon-dev-comp-immunol-67%C3%A2-2017-%C3%A2-18-29
#14
Sopacha Arayamethakorn, Premruethai Supungul, Anchalee Tassanakajon, Kuakarun Krusong
No abstract text is available yet for this article.
May 5, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28473207/quantification-of-cartilage-oligomeric-matrix-protein-comp-and-a-comp-neoepitope-in-synovial-fluid-of-patients-with-different-joint-disorders-by-novel-automated-assays
#15
P Lorenzo, A Aspberg, T Saxne, P Önnerfjord
OBJECTIVE: To develop automated immunoassays for the quantification of Cartilage Oligomeric Matrix Protein (COMP) and a COMP neoepitope in synovial fluid and to investigate their diagnostic potential in different joint conditions. METHODS: Two sandwich immunoassays were developed for the quantification of COMP and a COMP neoepitope, using an automated analyser (IDS-iSYS, Immunodiagnostic Systems, Boldon, UK). Assay performance was evaluated in terms of sensitivity, recovery, linearity, and intra- and inter-assay precision...
May 2, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28463545/meniscal-tissue-engineering-using-aligned-collagen-fibrous-scaffolds-comparison-of-different-human-cell-sources
#16
Jihye Baek, Sujata Sovani, Wonchul Choi, Sungho Jin, Shawn P Grogan, Darryl D'Lima
Hydrogel and electrospun scaffold materials support cell attachment and neotissue development and can be tuned to structurally and mechanically resemble native ECM by altering either electrospun fiber or hydrogel properties. In this study, we examined meniscus tissue generation from different human cell sources including meniscus cells derived from vascular and avascular regions, bone marrow-derived mesenchymal stem cells (hMSC), synovial cells, and cells from the infrapatellar fat pad (IPFP). All cells were seeded onto aligned electrospun collagen type I scaffolds and were optionally encapsulated in a tricomponent hydrogel...
May 2, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28460664/the-effect-of-flash-freezing-temperature-on-stallion-sperm-dna-structure
#17
R Serafini, D D Varner, W Bissett, T L Blanchard, S R Teague, C C Love
The effect of flash-freezing storage temperature on stallion sperm DNA has not been evaluated. Commonly, sperm are flash-frozen at various temperatures to preserve sperm DNA prior to analysis. It is unclear whether the temperature at which sperm are frozen and stored may affect the results of DNA assays. In this study, the neutral comet assay was used to evaluate the effect of flash-freezing storage temperature (freezer [-60 °C], dry ice [-78.5 °C], liquid nitrogen [-196 °C]) compared to fresh sperm DNA structure...
June 2017: Theriogenology
https://www.readbyqxmd.com/read/28454885/corrigendum-to-developmental-exposure-to-bisphenol-a-bpa-alters-sexual-differentiation-in-painted-turtles-chrysemys-picta-gen-comp-endocr-216-2015-77-85
#18
Caitlin M Jandegian, Sharon L Deem, Ramji K Bhandari, Casey M Holliday, Diane Nicks, Cheryl S Rosenfeld, Kyle W Selcer, Donald E Tillitt, Frederick S Vom Saal, Vanessa Vélez-Rivera, Ying Yang, Dawn K Holliday
No abstract text is available yet for this article.
June 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28445228/the-relationship-of-core-strength-and-activation-and-performance-on-three-functional-movement-screens
#19
Caleb D Johnson, Paul N Whitehead, Erin R Pletcher, Mallory S Faherty, Mita T Lovaleka, Shawn R Eagle, Karen A Keenan
Current measures of core stability utilized by clinicians and researchers suffer from several shortcomings. Three functional movement screens appear, at face-value, to be dependent on the ability to activate and control core musculature. These three screens may present a viable alternative to current measures of core stability. Thirty-nine subjects completed a deep squat, trunk stability push-up, and rotary stability screen. Scores on the three screens were summed to calculate a composite score (COMP). During the screens, muscle activity was collected to determine the length of time that the bilateral erector spinae, rectus abdominus, external oblique, and gluteus medius muscles were active...
April 18, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28439941/serological-biomarkers-detect-active-joint-destruction-and-inflammation-in-patients-with-haemophilic-arthropathy
#20
B Hua, E H N Olsen, S Sun, C N Gudme, L Wang, B Vandahl, K Roepstorff, M Kjelgaard-Hansen, B B Sørensen, Y Zhao, M A Karsdal, T Manon-Jensen
INTRODUCTION: Progressive arthropathy caused by recurrent joint bleeds is a severe complication in haemophilia. AIM: We investigated whether biomarkers of cartilage and bone degradation, and inflammation were altered in haemophilia patients and whether these biomarkers could identify haemophilia patients with arthropathy. METHODS: Serum from 35 haemophilia patients with varying degrees of arthropathy and 43 age- and gender-matched control subjects were analysed...
April 24, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
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