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https://www.readbyqxmd.com/read/28326436/reference-region-selection-and-the-association-between-the-rate-of-amyloid-accumulation-over-time-and-the-baseline-amyloid-burden
#1
Janusch Blautzik, Matthias Brendel, Julia Sauerbeck, Sebastian Kotz, Franziska Scheiwein, Peter Bartenstein, John Seibyl, Axel Rominger
Relative quantitative analysis of amyloid plaque burden in Alzheimer's disease (AD) patients can be reported as standardized uptake value ratio (SUVR) from positron emission tomography (PET). Here, the SUVR is the ratio of the mean amyloid radioligand retention in a composite (COMP) neocortical volume of interest (VOI) to that in a reference VOI, such as the cerebellum, brainstem (BST)/pons, or white matter (WM). Some longitudinal PET investigations show that the rate of amyloid accumulation to follow-up has an inverted U relationship with baseline amyloid SUVR relative to cerebellar or brainstem/pons reference VOIs...
March 22, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28319091/whole-genome-sequencing-identifies-rare-genotypes-in-comp-and-chadl-associated-with-high-risk-of-hip-osteoarthritis
#2
Unnur Styrkarsdottir, Hannes Helgason, Asgeir Sigurdsson, Gudmundur L Norddahl, Arna B Agustsdottir, Louise N Reynard, Amanda Villalvilla, Gisli H Halldorsson, Aslaug Jonasdottir, Audur Magnusdottir, Asmundur Oddson, Gerald Sulem, Florian Zink, Gardar Sveinbjornsson, Agnar Helgason, Hrefna S Johannsdottir, Anna Helgadottir, Hreinn Stefansson, Solveig Gretarsdottir, Thorunn Rafnar, Ina S Almdahl, Anne Brækhus, Tormod Fladby, Geir Selbæk, Farhad Hosseinpanah, Fereidoun Azizi, Jung Min Koh, Nelson L S Tang, Maryams Danesphour, Jose I Mayordomo, Corrine Welt, Peter S Braund, Nilesh J Samani, Lambertus A Kiemeney, L Stefan Lohmander, Claus Christiansen, Ole A Andreassen, Olafur Magnusson, Gisli Masson, Augustine Kong, Ingileif Jonsdottir, Daniel Gudbjartsson, Patrick Sulem, Helgi Jonsson, John Loughlin, Thorvaldur Ingvarsson, Unnur Thorsteinsdottir, Kari Stefansson
We performed a genome-wide association study of total hip replacements, based on variants identified through whole-genome sequencing, which included 4,657 Icelandic patients and 207,514 population controls. We discovered two rare signals that strongly associate with osteoarthritis total hip replacement: a missense variant, c.1141G>C (p.Asp369His), in the COMP gene (allelic frequency = 0.026%, P = 4.0 × 10(-12), odds ratio (OR) = 16.7) and a frameshift mutation, rs532464664 (p.Val330Glyfs*106), in the CHADL gene that associates through a recessive mode of inheritance (homozygote frequency = 0...
March 20, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28297309/production-review-and-impact-of-technical-quality-control-guidelines-in-a-national-context
#3
Michelle K Nielsen, Kyle E Malkoske, Erika Brown, Kevin Diamond, Normand Frenière, John Grant, Natalie Pomerleau-Dalcourt, Jason Schella, L John Schreiner, Laurent Tantôt, J Eduardo Villarreal-Barajas, Jean-Pierre Bissonnette
A close partnership between the Canadian Partnership for Quality Radiotherapy (CPQR) and the Canadian Organization of Medical Physicist's (COMP) Quality Assurance and Radiation Safety Advisory Committee (QARSAC) has resulted in the development of a suite of Technical Quality Control (TQC) guidelines for radiation treatment equipment; they outline specific performance objectives and criteria that equipment should meet in order to assure an acceptable level of radiation treatment quality. The adopted framework for the development and maintenance of the TQCs ensures the guidelines incorporate input from the medical physics community during development, measures the workload required to perform the QC tests outlined in each TQC, and remain relevant (i...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28294141/gear-a-database-of-genomic-elements-associated-with-drug-resistance
#4
Yin-Ying Wang, Wei-Hua Chen, Pei-Pei Xiao, Wen-Bin Xie, Qibin Luo, Peer Bork, Xing-Ming Zhao
Drug resistance is becoming a serious problem that leads to the failure of standard treatments, which is generally developed because of genetic mutations of certain molecules. Here, we present GEAR (A database of Genomic Elements Associated with drug Resistance) that aims to provide comprehensive information about genomic elements (including genes, single-nucleotide polymorphisms and microRNAs) that are responsible for drug resistance. Right now, GEAR contains 1631 associations between 201 human drugs and 758 genes, 106 associations between 29 human drugs and 66 miRNAs, and 44 associations between 17 human drugs and 22 SNPs...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28289615/importance-of-floating-chondrons-in-cartilage-tissue-engineering
#5
Hajar Shafaei, Hajar Bagernezhad, Hassan Bagernajad
BACKGROUND: Dedifferentiation of chondrocytes remains a major problem for cartilage tissue engineering. Chondrocytes loss differentiated phenotype in in vitro culture that is undesired for repair strategies. The chondrocyte is surrounded by a pericellular matrix (PCM), together forming the chondron. PCM has a positive effect on the maintenance of chondrocyte phenotype during culture in comparison to uncovered chondrocyte. Studies suggest that the PCM influence on functional properties of the chondrocytes...
January 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28282029/distribution-of-pericellular-matrix-molecules-in-the-temporomandibular-joint-and-their-chondroprotective-effects-against-inflammation
#6
Wern Cui Chu, Shipin Zhang, Timothy J Sng, Yu Jie Ong, Wen-Li Tan, Vivien Y Ang, Casper B Foldager, Wei Seong Toh
The objectives of this study were to (1) determine the distribution and synthesis of pericellular matrix (PCM) molecules (collagen VI, collagen IV and laminin) in rat temporomandibular joint (TMJ) and (2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones (fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands (anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs...
March 10, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28277753/the-absence-of-detectable-adamts-4-aggrecanase-1-activity-in-synovial-fluid-is-a-predictive-indicator-of-autologous-chondrocyte-implantation-success
#7
Karina Therese Wright, Jan Herman Kuiper, James Bruce Richardson, Pete Gallacher, Sally Roberts
BACKGROUND: Autologous chondrocyte implantation (ACI) is used worldwide in the treatment of cartilage defects in the knee. Several demographic and injury-specific risk factors have been identified that can affect the success of ACI treatment. However, the discovery of predictive biomarkers in this field has thus far been overlooked. PURPOSE: To identify potential biomarkers in synovial fluid and plasma that can be used in the preoperative setting to help optimize patient selection for cell-based cartilage repair strategies...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28270187/multiplex-serum-protein-analysis-reveals-potential-mechanisms-and-markers-of-response-to-hyperimmune-caprine-serum-in-systemic-sclerosis
#8
Niamh Quillinan, Kristina E N Clark, Bryan Youl, Jeffrey Vernes, Deirdre McIntosh, Syed Haq, Christopher P Denton
BACKGROUND: Hyperimmune caprine serum (HICS) is a novel biological therapy with potential benefit for skin in established diffuse cutaneous systemic sclerosis. Here we report multiplex protein analysis of blood samples from a placebo-controlled phase II clinical trial and explore mechanisms of action and markers of response. METHODS: Patients were treated with HICS (n = 10) or placebo (n = 10) over 26 weeks, with follow-up open-label treatment to 52 weeks in 14 patients...
March 7, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28268104/erratum-to-bothrops-fonsecai-snake-venom-activities-and-cross-reactivity-with-commercial-bothropic-antivenom-comp-biochem-physiol-c-191-2017-86-100
#9
Rita de Cássia O Collaço, Priscila Randazzo-Moura, Mariana L Tamascia, Igor Rapp F da Silva, Thalita Rocha, José C Cogo, Stephen Hyslop, Charles G Sanny, Léa Rodrigues-Simioni
No abstract text is available yet for this article.
March 4, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28261974/does-long-term-colchicine-prevent-degradation-of-collagen-fiber-network-in-osteoarthritis
#10
Ragini Srivastava, Siddharth K Das, Gautam Goel, Akash Asthana, Girdhar G Agarwal
AIM: Several studies have shown that colchicine exhibits an improvement in the symptoms of knee osteoarthritis (OA) but its effect on disease progression is unknown. To clarify the mechanism of action this study was done to see if colchicine prevents degradation of collagen fiber network in OA by studying serum cartilage oligomeric matrix protein (COMP) levels, a marker of cartilage turnover, over a period of 1 year. METHODS: Seventy-five patients received colchicine plus paracetamol and 75 received placebo alone for the same time period...
March 6, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28259585/corrigendum-to-usefulness-of-oxidative-stress-biomarkers-evaluated-in-the-snout-scraping-serum-and-peripheral-blood-cells-of-crocodylus-moreletii-from-southeast-campeche-for-assessment-of-the-toxic-impact-of-pahs-metals-and-total-phenols-comp-biochem-physiol
#11
Ricardo Dzul-Caamal, Abigail Hernández-López, Mauricio Gonzalez-Jáuregui, Sergio E Padilla, M Ivan Girón-Pérez, Armando Vega-López
No abstract text is available yet for this article.
March 1, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28255676/human-orbital-and-anterior-medial-prefrontal-cortex-intrinsic-connectivity-parcellation-and-functional-organization
#12
Zoe Samara, Elisabeth A T Evers, Alexandros Goulas, Harry B M Uylings, Grazyna Rajkowska, Johannes G Ramaekers, Peter Stiers
The orbital and medial prefrontal cortex (OMPFC) has been implicated in decision-making, reward and emotion processing, and psychopathology, such as depression and obsessive-compulsive disorder. Human and monkey anatomical studies indicate the presence of various cortical subdivisions and suggest that these are organized in two extended networks, a medial and an orbital one. Attempts have been made to replicate these neuroanatomical findings in vivo using MRI techniques for imaging connectivity. These revealed several consistencies, but also many inconsistencies between reported results...
March 2, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28251065/interleukin-6-and-ratio-of-plasma-interleukin-6-interleukin-10-as-risk-factors-of-symptomatic-lumbar-osteoarthritis
#13
I Ketut Suyasa, I Ketut Siki Kawiyana, I Made Bakta, I Gde Raka Widiana
AIM: To determine the role of cartilage oligomeric matrix protein (COMP), interleukin (IL)-6, IL-10 and ratio of IL-6/IL-10 as risk factors of symptomatic lumbar osteoarthritis (OA) in postmenopausal women with estrogen deficiency. METHODS: Case-control study had been conducted in Sanglah General Hospital from October 2015 until March 2016. The blood samples were obtained and analyzed by enzyme-linked immunosorbent assay (ELISA). RESULTS: From 44 pairs of samples which divided into 44 samples as case group and 44 samples as control group showed that high level of COMP in estrogen deficiency postmenopausal women were not at risk (OR = 0...
February 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28238939/temporary-removal-unitary-circular-code-motifs-in-genomes-of-eukaryotes
#14
Karim El Soufi, Christian J Michel
The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.
February 24, 2017: Bio Systems
https://www.readbyqxmd.com/read/28229430/differences-in-biomarkers-of-cartilage-matrix-turnover-and-their-changes-over-2%C3%A2-years-in-adolescent-and-adult-volleyball-athletes
#15
Heide Boeth, Aoife MacMahon, A Robin Poole, Frank Buttgereit, Patrik Önnerfjord, Pilar Lorenzo, Cecilia Klint, Anna Pramhed, Georg N Duda
BACKGROUND: This study aimed the feasibility to assess longitudinal changes in biomarkers of cartilage turnover and to determine their relationship with patient-rated outcomes over 2 years in volleyball athletes. METHODS: Thirty-seven athletes were studied: 18 adolescents (age 15.9 ± 0.64 years) in a 2-year intensive volleyball training program and 19 adult recreational volleyball players (age 46.5 ± 4.9 years). Blood and serum samples were taken at baseline (BL) and 2-year follow-up (FU)...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28225870/pdk2-promotes-chondrogenic-differentiation-of-mesenchymal-stem-cells-by-upregulation-of-sox6-and-activation-of-jnk-mapk-erk-pathway
#16
H Wang, X B Shan, Y J Qiao
This study was undertaken to clarify the role and mechanism of pyruvate dehydrogenase kinase isoform 2 (PDK2) in chondrogenic differentiation of mesenchymal stem cells (MSCs). MSCs were isolated from femurs and tibias of Sprague-Dawley rats, weighing 300-400 g (5 females and 5 males). Overexpression and knockdown of PDK2 were transfected into MSCs and then cell viability, adhesion and migration were assessed. Additionally, the roles of aberrant PDK2 in chondrogenesis markers SRY-related high mobility group-box 6 (Sox6), type ΙΙ procollagen gene (COL2A1), cartilage oligomeric matrix protein (COMP), aggrecan (AGC1), type ΙX procollagen gene (COL9A2) and collagen type 1 alpha 1 (COL1A1) were measured by quantitative reverse-transcription polymerase chain reaction (qRT-PCR)...
February 16, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28216310/adamts-and-adam-metalloproteinases-in-osteoarthritis-looking-beyond-the-usual-suspects
#17
REVIEW
C-Y Yang, A Chanalaris, L Troeberg
INTRODUCTION: Matrix metalloproteinases (MMPs) and 'aggrecanase' a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) are well established to play key roles in osteoarthritis (OA) through degradation of extracellular matrix (ECM) type II collagen and aggrecan, and are thus potential targets for development of OA therapies. OBJECTIVE: This paper aims to provide a comprehensive review of the expression and potential roles of other, lesser-known ADAMTSs and related adamalysins (or a disintegrin and metalloproteinases (ADAMs)) in cartilage, with a view to identifying potentially protective or homoeostatic metalloproteinases in the joint and informing consequent selective inhibitor design...
February 13, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28212692/oxygen-desaturation-index-differs-significantly-between-types-of-sleep-software
#18
Yvonne Ng, Simon A Joosten, Bradley A Edwards, Anthony Turton, Helen Romios, Thilini Samarasinghe, Shane Landry, Darren R Mansfield, Garun S Hamilton
STUDY OBJECTIVES: The aim of this study was to compare the oxygen desaturation index (ODI) generated by two different sleep software systems. METHODS: Participants undergoing diagnostic polysomnography for suspected obstructive sleep apnea underwent simultaneous oximetry recording using the ResMedApneaLink Plus device (AL) and Compumedics Profusion PSG3 system (Comp). The ODI was calculated by the algorithms in the respective software of each system. To determine if differences were due to algorithm or recording devices, the Comp software was also used to generate ODI values using oximetry data from the AL...
February 15, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28208081/molecular-synergy-in-biolubrication-the-role-of-cartilage-oligomeric-matrix-protein-comp-in-surface-structuring-of-lubricin
#19
Akanksha Raj, Min Wang, Chao Liu, Liaquat Ali, Niclas G Karlsson, Per M Claesson, Andra Dėdinaitė
HYPOTHESIS: Synovial surfaces are lubricated by biomolecular aggregates that act in synergy, and lubricin is one key biolubricant. Its molecular structure allows extensive hydration and this is conducive to its lubrication performance. However, in order to fullfil its lubrication function it needs to be anchored and oriented on the surface in a proper way. We suggest that cartilage oligomeric matrix protein (COMP) is one of the biomolecules that promotes anchoring of lubricin in a fashion that facilitates lubrication...
June 1, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28206685/claustrum-of-the-short-tailed-fruit-bat-carollia-perspicillata-alignment-of-cellular-orientation-and-functional-connectivity
#20
Rena Orman, Richard Kollmar, Mark Stewart
The claustrum is a gray-matter structure that underlies neocortex and reciprocates connections with cortical and subcortical targets. In lower mammals, the claustrum is directly adjacent to neocortex, making the definition of claustral boundaries challenging. Latexin, an endogenous inhibitor of metallocarboxypeptidases, localizes to claustral cells, enabling a clear delineation of claustrum. Given its proportionately large claustrum, we hypothesized that the short-tailed fruit bat, Carollia perspicillata, can be a useful model for claustral structure-function relations...
April 15, 2017: Journal of Comparative Neurology
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