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https://www.readbyqxmd.com/read/29143458/comp-report-cqpr-technical-quality-control-guidelines-for-ct-simulators
#1
Philippe Després, Stewart Gaede
The Canadian Organization of Medical Physicists (COMP), in close partnership with the Canadian Partnership for Quality Radiotherapy (CPQR) has developed a series of Technical Quality Control (TQC) guidelines for radiation treatment equipment. These guidelines outline the performance objectives that equipment should meet in order to ensure an acceptable level of radiation treatment quality. The TQC guidelines have been rigorously reviewed and field tested in a variety of Canadian radiation treatment facilities...
November 16, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29109936/a-study-of-harmful-drug-drug-interactions-due-to-polypharmacy-in-hospitalized-patients-in-goa-medical-college
#2
Akshay Khandeparkar, Padmanabh V Rataboli
Introduction: Concomitant use of multiple drugs is often indicated to manage comorbid conditions and enhance efficacy. Such concomitant use of multiple drugs (five or more drugs) has been defined as "polypharmacy." Polypharmacy has been associated with adverse consequences such as greater healthcare costs, increased risk of adverse drug events, drug-drug interactions (DDIs), medication nonadherence, reduced functional capacity, and multiple geriatric syndromes. This study evaluated number of potential harmful DDIs due to polypharmacy...
October 2017: Perspectives in Clinical Research
https://www.readbyqxmd.com/read/29108257/regulation-of-neuroinflammation-by-matrix-metalloproteinase-8-inhibitor-derivatives-in-activated-microglia-and-astrocytes
#3
Eun-Jung Lee, Min-Ji Choi, Gyeongjin Lee, Bhakta Prasad Gaire, Ji Woong Choi, Hee-Sun Kim
Matrix metalloproteinases (MMPs) play a pivotal role in neuroinflammation that is associated with neurodegenerative diseases. Our group recently reported that MMP-8 mediates inflammatory reactions by modulating the processing of TNF-α. To improve the efficacy of the currently available MMP-8 inhibitor (M8I), we have synthesized structurally modified M8I derivatives (comp 2, 3, 4, 5) and compared their efficacy with original compound (comp 1). Among M8I derivatives, comp 2, 3, and 5 inhibited the production of NO, ROS, and IL-6 more efficiently than the original compound in lipopolysaccharide (LPS)-stimulated microglia...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29105312/acute-effect-of-a-resistance-exercise-session-on-markers-of-cartilage-breakdown-and-inflammation-in-women-with-rheumatoid-arthritis
#4
Ana Carolina Pereira Nunes Pinto, Jamil Natour, Charlles Heldan de Moura Castro, Marina Eloi, Império Lombardi Junior
AIM: To assess the acute effect of resistance exercise (RE) on circulating biomarkers of cartilage breakdown and inflammation in women with rheumatoid arthritis (RA). METHODS: Thirty-four volunteers (17 with and 17 without RA), participated in a 25 min RE session (knee extension, knee flexion, hip abduction and hip adduction) with one set of 12 repetitions at 50% of one repetition maximum (1RM) and one set of eight repetitions at 75% of 1RM. Blood samples were collected 30 and 5 min before, immediately after and 1, 2 and 24 h after the session...
November 3, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29104872/decreased-plasma-comp-and-increased-plasma-ctx-ii-levels-in-a-chinese-pseudoachondroplasia-family-with-novel-comp-mutation
#5
Chongjuan Gu, Zhao Yang, Hao Tan, Yingying Zhang, Yilu Lu, Yongxin Ma
Pseudoachondroplasia (PSACH) is an autosomal dominant osteochondrodysplasia caused by mutations in the gene encoding cartilage oligomeric matrix protein (COMP). Accurate clinical diagnosis of PSACH is sometimes difficult. Here, we identified a novel COMP mutation (c.1675G>A, p.Glu559Lys) in a Chinese PSACH family. We detected the plasma levels of COMP and type II collagen (CTX-II) in the four affected individuals. The results showed the levels of plasma COMP significantly decreased and plasma CTX-II significantly increased in the three PSACH patients with COMP mutation...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29100894/corrigendum-to-glyphosate-based-herbicide-exposure-causes-antioxidant-defence-responses-in-the-fruit-fly-drosophila-melanogaster-previously-published-at-cbpc-comp-biochem-physiol-c-185-186-2016-94-101
#6
Lais Mattos de Aguiar, Fernanda Hernandes Figueira, Marco Silva Gottschalk, Carlos Eduardo da Rosa
No abstract text is available yet for this article.
October 31, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29090639/platelet-rich-concentrate-in-serum-free-medium-enhances-cartilage-specific-extracellular-matrix-synthesis-and-reduces-chondrocyte-hypertrophy-of-human-mesenchymal-stromal-cells-encapsulated-in-alginate
#7
Shani Samuel, Raja Elina Ahmad, Thamil Selvee Ramasamy, Puvanan Karunanithi, Sangeetha Vasudevaraj Naveen, Tunku Kamarul
Platelet-rich concentrate (PRC), used in conjunction with other chondroinductive growth factors, have been shown to induce chondrogenesis of human mesenchymal stromal cells (hMSC) in pellet culture. However, pellet culture systems promote cell hypertrophy and the presence of other chondroinductive growth factors in the culture media used in previous studies obscures accurate determination of the effect of platelet itself in inducing chondrogenic differentiation. Hence, this study aimed to investigate the effect of PRC alone in enhancing the chondrogenic differentiation potential of human mesenchymal stromal cells (hMSC) encapsulated in three-dimensional alginate constructs...
November 1, 2017: Platelets
https://www.readbyqxmd.com/read/29089318/comparative-analysis-of-the-scope-of-european-union-paediatric-investigation-plans-with-corresponding-orphan-designations
#8
Andrea Ecker, Segundo Mariz, Frauke Naumann-Winter, Koenraad Norga, Ingeborg Barisic, Thomas Girard, Paolo Tomasi, Dirk Mentzer, Bruno Sepodes
BACKGROUND: Market forces may not be sufficient to stimulate research and development of medicines for small patient populations, such as children and patients with rare diseases. Both the European Union Orphan and Paediatric Regulations were introduced to address the unmet public health needs of these smaller patient populations through the use of incentives, rewards and obligations. Developers for new medicines for rare diseases must agree a paediatric investigation plan (PIP) or waiver with the European Medicines Agency's (EMA) Paediatric Committee (PDCO), and can also apply for an orphan designation (OD) from the EMA's Committee of Orphan Medicinal Products (COMP)...
October 31, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29077223/sensitivity-of-serum-concentration-of-cartilage-biomarkers-to-21-days-of-bed-rest
#9
Anna-Maria Liphardt, Annegret Mündermann, Thomas P Andriacchi, Silvia Achtzehn, Martina Heer, Joachim Mester
The objective of the study was to test the hypothesis that serum levels of cartilage oligomeric matrix protein (COMP) would decrease and serum levels of tumor-necrosis factor alpha (TNF-α) and selected matrix metalloproteinases (MMPs) would increase in response to bed rest (BR) and that these changes are unaffected by the intake of potassium bicarbonate or whey protein. Seven and nine healthy male subjects participated in two 21-day 6° head down tilt crossover BR-studies with nutrition interventions. Serum samples were taken before, during, and after BR and biomarker concentrations were measured using commercial enzyme-linked immunosorbent assays...
October 27, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29041530/experimental-demonstration-of-fronthaul-flexibility-for-enhanced-comp-service-in-5g-radio-and-optical-access-networks
#10
Jiawei Zhang, Yuefeng Ji, Hao Yu, Xingang Huang, Han Li
The RAN architecture towards mobile 5G and beyond is undergoing a fundamental evolution, which brings optics into the radio world. Fronthaul is a new segment that leverages on the advantages of optical communication for RAN transport. However, the current fronthaul architecture shows a fixed connection between an RRH and a BBU, which leads to inefficient resource utilization. In this paper, we focus on the fronthaul flexibility that allows "any-RRH to any-BBU" connection. In particular, we consider a CoMP service and discuss how flexible optical fronthaul helps to improve its performance...
September 4, 2017: Optics Express
https://www.readbyqxmd.com/read/29030641/lubricin-binds-cartilage-proteins-cartilage-oligomeric-matrix-protein-fibronectin-and-collagen-ii-at-the-cartilage-surface
#11
Sarah A Flowers, Agata Zieba, Jessica Örnros, Chunsheng Jin, Ola Rolfson, Lena I Björkman, Thomas Eisler, Sebastian Kalamajski, Masood Kamali-Moghaddam, Niclas G Karlsson
Lubricin, a heavily O-glycosylated protein, is essential for boundary lubrication of articular cartilage. Strong surface adherence of lubricin is required given the extreme force it must withstand. Disulfide bound complexes of lubricin and cartilage oligomeric matrix protein (COMP) have recently been identified in arthritic synovial fluid suggesting they may be lost from the cartilage surface in osteoarthritis and inflammatory arthritis. This investigation was undertaken to localise COMP-lubricin complexes within cartilage and investigate if other cartilage proteins are involved in anchoring lubricin to the joint...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29024831/multiple-slc26a2-mutations-occurring-in-a-three-generational-family
#12
Ana Coral Barreda-Bonis, Jimena Barraza-García, Manuel Parrón, Ignacio Pastor, Karen E Heath, Isabel González-Casado
Multiple epiphyseal dysplasias (MED) are a group of heterogeneous skeletal dysplasias, which share a common phenotype: short stature, skeletal deformities, joint pain and early onset osteoarthritis. Mutations in COMP account for approximately half of autosomal dominant MED cases whilst SLC26A2 mutations account for ∼25% of the recessive cases in the Caucasian population. We present here an interesting family, which was thought to initially have an autosomal dominant skeletal dysplasia. Using a targeted sequencing skeletal dysplasia panel, the proband was found to be a compound heterozygote for two mutations in SLC26A2, one novel mutation, p...
October 9, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29023015/evaluation-of-growth-performances-of-some-locally-farmed-maize-zea-mays-l-in-cross-river-state-nigeria-under-different-concentrations-of-silicon
#13
M O Ononyume, E A Edu, T Okoh, A P Inegbedion
OBJECTIVE: Growth performances of four maize varieties (91 SUWANI, TZL COMP 4, DT STR Y SYN 2 and IWO SYN C2) were investigated at four levels of silicon concentration (0, 2500, 5000 and 7500 mg, with 0 mg as control). METHODOLOGY: Viable seeds were planted in polythene bags (64 bags) containing soil in a randomized complete block design (a 4×4 factorial experiment) with four replications. Plant height, stem girth, leaf area and leaf number were evaluated at 4, 6, 8 and 10 weeks after planting...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29022912/tenomodulin-is-essential-for-prevention-of-adipocyte-accumulation-and-fibrovascular-scar-formation-during-early-tendon-healing
#14
Dasheng Lin, Paolo Alberton, Manuel Delgado Caceres, Elias Volkmer, Matthias Schieker, Denitsa Docheva
Tenomodulin (Tnmd) is the best-known mature marker for tendon and ligament lineage cells. It is important for tendon maturation, running performance and has key implications for the resident tendon stem/progenitor cells (TSPCs). However, its exact functions during the tendon repair process still remain elusive. Here, we established an Achilles tendon injury model in a Tnmd knockout (Tnmd(-/-)) mouse line. Detailed analyses showed not only a very different scar organization with a clearly reduced cell proliferation and expression of certain tendon-related genes, but also increased cell apoptosis, adipocyte and blood vessel accumulation in the early phase of tendon healing compared with their wild-type (WT) littermates...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29022157/radiosurgery-in-trochlear-and-abducens-nerve-schwannomas-case-series-and-systematic-review
#15
Iulia Peciu-Florianu, Constantin Tuleasca, Jean-Nicolas Comps, Luis Schiappacasse, Michele Zeverino, Roy Thomas Daniel, Marc Levivier
INTRODUCTION: Schwannomas involving the occulomotor cranial nerves  (CNs; III, IV and VI), can be disabling, due to the associated diplopia and decreased quality of life and are extremely rare. We evaluated the role of Gamma Knife surgery (GKS) in these cases. METHODS: Five patients with CN IV and VI schwannomas (three and two, respectively) were treated in Lausanne University Hospital between 2010 and 2015. Four benefitted from upfront GKS and one from a combined approach (planned subtotal resection followed by GKS), due to a large preoperative tumour volume (size, 3 × 2 × 2...
October 11, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29017718/corrigendum-to-house-sparrows-mitigate-growth-effects-of-post-natal-glucocorticoid-exposure-at-the-expense-of-longevity-gen-comp-endocrinol-253-2017-1-12
#16
Jacquelyn K Grace, Louise Froud, Alizée Meillère, Frédéric Angelier
No abstract text is available yet for this article.
January 1, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28987289/nonclinical-data-supporting-orphan-medicinal-product-designations-lessons-from-rare-neurological-conditions
#17
REVIEW
Maria E Sheean, Violeta Stoyanova-Beninska, Giuseppe Capovilla, Dinah Duarte, Matthias P Hofer, Michel Hoffmann, Armando Magrelli, Segundo Mariz, Stelios Tsigkos, Evyenia Shaili, Benedetta Polsinelli, Mario Ricciardi, Milton Bonelli, Pavel Balabanov, Kristina Larsson, Bruno Sepodes
Here, we provide an in-depth literature and experience-based review of nonclinical models and data used to support orphan medicinal product designations (OMPDs) in rare neurodegenerative conditions. The Committee for Orphan Medicinal Products (COMP) of the European Medicines Agency updates its assessment processes based on scientific progress and aims to provide transparent criteria required in support of OMPDs. Thus, we also provide an updated analysis of existing nonclinical models in selected conditions and identify key features of nonclinical studies that are crucial for the support of OMPDs...
October 4, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28970449/assessment-of-drug-information-service-in-public-and-private-sector-tertiary-care-hospitals-in-the-eastern-province-of-saudi-arabia
#18
Sawsan Abdullah Alamri, Raniah Ali Al Jaizani, Atta Abbas Naqvi, Mastour Safer Al Ghamdi
Drug information service is a dedicated and specialized service provided by pharmacists to enhance knowledge of medicines use, promote rational prescribing among prescribers, and reduce medication errors. Saudi Arabia has a National Drug and Poison Information Center (NDPIC) responsible for answering drug queries. There is a lack of literature that reports the current scenario of drug information services in the country, especially the Eastern Province. This study reported the current status of drug information services being provided among tertiary care hospitals of the Eastern Province of Saudi Arabia...
July 4, 2017: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/28969626/effects-of-dietary-supplementation-with-a-standardized-aqueous-extract-of-terminalia-chebula-fruit-ayuflex-%C3%A2-on-joint-mobility-comfort-and-functional-capacity-in-healthy-overweight-subjects-a-randomized-placebo-controlled-clinical-trial
#19
RANDOMIZED CONTROLLED TRIAL
H L Lopez, S M Habowski, J E Sandrock, B Raub, A Kedia, E J Bruno, T N Ziegenfuss
BACKGROUND: Joint and connective tissue integrity, comfort and function are paramount to optimal performance in exercise, recreational and occupational activities. The fruit of Terminalia chebula has been used extensively in various traditional health systems for different ailments, with additional preclinical and clinical data demonstrating antioxidant and anti-inflammatory potential. The aim of this study was to evaluate the effects of a standardized aqueous extract of Terminalia chebula fruit (AyuFlex®) dietary supplementation on joint mobility, comfort, and functional capacity in healthy overweight subjects...
October 2, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28951969/quantitative-evaluation-of-the-relationship-between-comp-promoter-methylation-and-the-susceptibility-and-curve-progression-of-adolescent-idiopathic-scoliosis
#20
Sai-Hu Mao, Bang-Ping Qian, Benlong Shi, Ze-Zhang Zhu, Yong Qiu
PURPOSE: The cartilage oligomeric matrix protein (COMP) was reported to be down-regulated in adolescent idiopathic scoliosis (AIS). The purposes of the study were to evaluate the roles of COMP promoter methylation on the abnormal gene expression and the epigenetic phenotype in AIS. METHODS: DNA samples of 50 AIS patients and 50 healthy controls were analyzed. Five CpG sites of COMP gene were amplified and sequenced using the polymerase chain reaction (PCR) and the pyrophosphate sequencing technology, while the COMP gene expression was evaluated using real-time PCR...
September 26, 2017: European Spine Journal
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