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https://www.readbyqxmd.com/read/29786423/electrochemical-determination-of-tnt-dnt-rdx-and-hmx-with-gold-nanoparticles-poly-carbazole-aniline-film-modified-glassy-carbon-sensor-electrodes-imprinted-for-molecular-recognition-of-nitroaromatics-and-nitramines
#1
Şener Sağlam, Ayşem Üzer, Erol Erçağ, Reşat Apak
Since nitroaromatic and nitramine type energetic materials, mostly arising from military activities, are persistent pollutants in soil and groundwater, on-site sensing of these hazardous chemicals has gained importance. A novel electrochemical sensor was designed for detecting nitroaromatic and nitramine type energetic materials, relying on gold nanoparticles (Aunano ) -modified glassy carbon (GC) electrode coated with nitro-energetic memory poly(carbazole-aniline) copolymer (Cz- co-ANI) film (e.g., TNT memory-GC/P(Cz- co-ANI)-Aunano modified electrode)...
May 22, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29781144/comp-report-cpqr-technical-quality-control-guidelines-for-conventional-radiotherapy-simulators
#2
Marie-Joëlle Bertrand
The Canadian Organization of Medical Physicists (COMP), in close partnership with the Canadian Partnership for Quality Radiotherapy (CPQR) has developed a series of Technical Quality Control (TQC) guidelines for radiation treatment equipment. These guidelines outline the performance objectives that equipment should meet in order to ensure an acceptable level of radiation treatment quality. The TQC guidelines have been rigorously reviewed and field tested in a variety of Canadian radiation treatment facilities...
May 21, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29774080/microrna-193b-3p-regulates-chondrogenesis-and-chondrocyte-metabolism-by-targeting-hdac3
#3
Fangang Meng, Zhiwen Li, Zhiqi Zhang, Zibo Yang, Yan Kang, Xiaoyi Zhao, Dianbo Long, Shu Hu, Minghui Gu, Suiwen He, Peihui Wu, Zongkun Chang, Aishan He, Weiming Liao
Histone deacetylase 3 (HDAC3) plays a pivotal role in the repression of cartilage-specific gene expression in human chondrocytes. The aim of this study was to determine whether microRNA-193b-3p (miR-193b-3p) regulates the expression of HDAC3 during chondrogenesis and chondrocyte metabolism. Methods: miR-193b-3p expression was assessed in a human mesenchymal stem cell (hMSC) model of chondrogenesis, in interleukin-1β (IL-1β)-treated primary human chondrocytes (PHCs), and in non-degraded and degraded cartilage...
2018: Theranostics
https://www.readbyqxmd.com/read/29762030/structure-function-analysis-of-the-extended-conformation-of-a-polyketide-synthase-module
#4
Xiuyuan Li, Natalia Sevillano, Florencia La Greca, Lindsay Deis, Yu-Chen Liu, Marc C Deller, Irimpan I Mathews, Tsutomu Matsui, David E Cane, Charles S Craik, Chaitan Khosla
Catalytic modules of assembly-line polyketide synthases (PKSs) have previously been observed in two very different conformations-an "extended" architecture and an "arch-shaped" architecture-although the catalytic relevance of neither has been directly established. By the use of a fully human naïve antigen-binding fragment (Fab ) library, a high-affinity antibody was identified that bound to the extended conformation of a PKS module, as verified by X-ray crystallography and tandem size-exclusion chromatography-small-angle X-ray scattering (SEC-SAXS)...
May 18, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29748528/salmon-calcitonin-attenuates-degenerative-changes-in-cartilage-and-subchondral-bone-in-lumbar-facet-joint-in-an-experimental-rat-model
#5
Yu Gou, Faming Tian, Qingfu Kong, Tiangang Chen, Hetong Li, Qinglie Lv, Liu Zhang
BACKGROUND Facet joint degeneration (FJD) is one of the common causes of low back pain (LBP), and estrogen deficiency is one of the triggers for FJD. Calcitonin may possess the potential for treating osteoarthritis, but to date the hormone has not been studied in the treatment of FJD. Therefore, the aim of this study was to investigate the effects of salmon calcitonin (sCT) on FJD induced by estrogen deficiency after ovariectomy (OVX). MATERIAL AND METHODS Thirty female Sprague-Dawley rats were randomly assigned to 3 groups: the OVX group received bilateral OVX, the OVX + sCT group received subcutaneous administration of sCT (16 IU/kg/2 days) following bilateral OVX, and the Sham group received sham surgery...
May 7, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29745011/comp-report-cpqr-technical-quality-control-guidelines-for-major-dosimetry-equipment
#6
Gérard Lagmago Kamta
The Canadian Organization of Medical Physicists (COMP), in close partnership with the Canadian Partnership for Quality Radiotherapy (CPQR) has developed a series of Technical Quality Control (TQC) guidelines for radiation treatment equipment. These guidelines outline the performance objectives that equipment should meet to ensure an acceptable level of radiation treatment quality. The TQC guidelines have been rigorously reviewed and field tested in a variety of Canadian radiation treatment facilities. The development process enables rapid review and update to keep the guidelines current with changes in technology (the most update version of this guideline can be found on the CPQR website)...
May 9, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29744590/anatomical-organization-of-the-cerebrum-of-the-desert-locust-schistocerca-gregaria
#7
Joss von Hadeln, Vanessa Althaus, Linda Häger, Uwe Homberg
The desert locust Schistocerca gregaria is a major agricultural pest in North Africa and the Middle East. As such, it has been intensely studied, in particular with respect to population dynamics, sensory processing, feeding behavior flight and locomotor control, migratory behavior, and its neuroendocrine system. Being a long-range migratory species, neural mechanisms underlying sky compass orientation have been studied in detail. To further understand neuronal interactions in the brain of the locust, a deeper understanding of brain organization in this insect has become essential...
May 9, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29740124/a-targeted-boost-and-sort-immunization-strategy-using-escherichia-coli-bama-identifies-rare-growth-inhibitory-antibodies
#8
Rajesh Vij, Zhonghua Lin, Nancy Chiang, Jean-Michel Vernes, Kelly M Storek, Summer Park, Joyce Chan, Y Gloria Meng, Laetitia Comps-Agrar, Peng Luan, Sophia Lee, Kellen Schneider, Jack Bevers, Inna Zilberleyb, Christine Tam, Christopher M Koth, Min Xu, Avinash Gill, Marcy R Auerbach, Peter A Smith, Steven T Rutherford, Gerald Nakamura, Dhaya Seshasayee, Jian Payandeh, James T Koerber
Outer membrane proteins (OMPs) in Gram-negative bacteria are essential for a number of cellular functions including nutrient transport and drug efflux. Escherichia coli BamA is an essential component of the OMP β-barrel assembly machinery and a potential novel antibacterial target that has been proposed to undergo large (~15 Å) conformational changes. Here, we explored methods to isolate anti-BamA monoclonal antibodies (mAbs) that might alter the function of this OMP and ultimately lead to bacterial growth inhibition...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29721643/the-distribution-patterns-of-comp-and-matrilin-3-in-septal-alar-and-triangular-cartilages-of-the-human-nose
#9
Paul Severin Wiggenhauser, Silke Schwarz, Nicole Rotter
The biomechanical characteristics of septal cartilage depend strongly on the distinct extracellular matrix of cartilage tissue; therefore, it is essential that the components of this matrix are identified and understood. Cartilage oligomeric matrix protein (COMP) and matrilin-3 are localised in articular cartilage. This study was the first to examine all subtypes of mature human nasal cartilages (alar, triangular and septal) with specific attention to the distribution of COMP and matrilin-3. Three whole fresh-frozen noses from human donors were dissected, and exemplary biopsies were examined using histochemical staining (haematoxylin and eosin and Alcian blue) and immunohistochemistry (collagen II, COMP and matrilin-3)...
May 2, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29691435/elf3-contributes-to-cartilage-degradation-in-vivo-in-a-surgical-model-of-post-traumatic-osteoarthritis
#10
Elisabeth B Wondimu, Kirsty L Culley, Justin Quinn, Jun Chang, Cecilia L Dragomir, Darren A Plumb, Mary B Goldring, Miguel Otero
The E-74 like factor 3 (ELF3) is a transcription factor induced by inflammatory factors in various cell types, including chondrocytes. ELF3 levels are elevated in human cartilage from patients with osteoarthritis (OA), and ELF3 contributes to the IL-1β-induced expression of genes encoding Mmp13, Nos2, and Ptgs2/Cox2 in chondrocytes in vitro. Here, we investigated the contribution of ELF3 to cartilage degradation in vivo, using a mouse model of OA. To this end, we generated mouse strains with cartilage-specific Elf3 knockout (Col2Cre:Elf3f/f ) and Comp-driven Tet-off-inducible Elf3 overexpression (TRE-Elf3:Comp-tTA)...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29667617/combination-of-stromal-vascular-fraction-and-ad-comp-ang1-gene-therapy-improves-long-term-therapeutic-efficacy-for-diabetes-induced-erectile-dysfunction
#11
Guo-Nan Yin, Lin Wang, Xiang-Nan Lin, Lei Shi, Zhen-Lin Gao, Feng-Chan Han, Ping Li, Yin-Chuan Jin, Jun-Kyu Suh, Ji-Kan Ryu, Xiong Wang, Hai-Rong Jin
Men with diabetic erectile dysfunction (ED) respond poorly to the currently available oral phosphodiesterase-5 inhibitors. Therefore, functional therapies for diabetic ED are needed. Stromal vascular fraction (SVF) and the adenovirus-mediated cartilage oligomeric matrix angiopoietin-1 (Ad-COMP-Ang1) gene are known to play critical roles in penile erection. We previously reported that SVF and Ad-COMP-Ang1 have only a short-term effect in restoring erectile function. Further improvements to ED therapy are needed for long-lasting effects...
April 17, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29663644/biomimetic-sulfated-polyethylene-glycol-hydrogel-inhibits-proteoglycan-loss-and-tumor-necrosis-factor-%C3%AE-induced-expression-pattern-in-an-osteoarthritis-in-vitro-model
#12
Shabnam Hemmati-Sadeghi, Pradip Dey, Jochen Ringe, Rainer Haag, Michael Sittinger, Tilo Dehne
This study aimed to evaluate the potential of an anti-inflammatory polyethylene glycol (PEG) hydrogel for osteoarthritis (OA) management in an OA in vitro model. Freshly isolated porcine chondrocytes were maintained in high-density cultures to form cartilage-like three-dimensional micromasses. Recombinant porcine tumor necrosis factor-alpha (TNF-α) was used to induce OA-like changes. Normal and OA-like micromasses were treated with dendritic polyglycerol sulfate-based PEG hydrogel. Live/dead staining showed that all micromasses remained vital and presented similar morphological characteristics...
April 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29653405/modeling-margin-of-stability-with-feet-in-place-following-a-postural-perturbation-effect-of-altered-anthropometric-models-for-estimated-extrapolated-centre-of-mass
#13
Keaton A Inkol, Andrew H Huntley, Lori Ann Vallis
BACKGROUND: Maintaining the centre of mass (CoM) of the body within the base of support is a critical component of upright balance; the ability to accurately quantify balance recovery mechanisms is critical for many research teams. RESEARCH QUESTION: The purpose of this study was to investigate how exclusion of specific body segments in an anthropometric CoM model influenced a dynamic measure of postural stability, the margin of stability (MoS), following a support-surface perturbation...
March 30, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29648449/knockout-of-rapc-improves-bacillomycin-d-yield-based-on-de-novo-genome-sequencing-of-bacillus-amyloliquefaciens-fmbj
#14
Jing Sun, Shiquan Qian, Jing Lu, Yanan Liu, Fengxia Lu, Xiaomei Bie, Zhaoxin Lu
Bacillus amyloliquefaciens, a gram-positive and soil-dwelling bacterium, could produce secondary metabolites that suppress plant pathogens. In this study, we provided the whole genome sequence results of B. amyloliquefaciens fmbJ which had one circular chromosome of 4,193,344 bp with 4,249 genes, 87 transfer RNA genes, and 27 rRNA genes. In addition, fmbJ was found to contain several gene clusters of antimicrobial lipopeptides (bacillomycin D, surfactin, and fengycin) and bacillomycin D homologues were further comprehensively identified...
April 12, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29623591/correction-to-intramuscular-clodronate-in-erosive-osteoarthritis-of-the-hand-is-effective-on-pain-and-reduces-serum-comp-a-randomized-pilot-trial-the-er-o-d-e-study-erosive-osteoarthritis-and-disodium-clodronate-evaluation
#15
Gianantonio Saviola, Lul Abdi-Ali, Maria Rosaria Povino, Lorella Campostrini, Silvano Sacco, Luca Dalle Carbonare
One of the author names on this article was incorrectly tagged during the article mark-up; Luca Dalle Carbonare's name has now been correctly tagged, with first name 'Luca' and last name 'Dalle Carbonare'.
April 6, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29610929/comp-angiopoietin-1-ameliorates-inflammation-induced-lymphangiogenesis-in-dextran-sulfate-sodium-dss-induced-colitis-model
#16
Ae Sin Lee, Mi Jeong Sung, Won Kim, Yu Jin Jung
Alterations in the intestinal lymphatic network are pathological processes as related to inflammatory bowel disease (IBD). In this study, we demonstrated that reduction in inflammation-induced lymphangiogenesis ameliorates experimental acute colitis. A soluble and stable angiopoietin-1 (Ang1) variant, COMP-Ang1, possesses anti-inflammatory and angiogenic effects. We investigated the effects of COMP-Ang1 on an experimental colonic inflammation model. Experimental colitis was induced in mice by administering 3% dextran sulfate sodium (DSS) via drinking water...
April 2, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29609932/corrigendum-to-short-term-effect-of-add-on-bell-pepper-capsicum-annuum-var-grossum-juice-with-integrated-approach-of-yoga-therapy-on-blood-glucose-levels-and-cardiovascular-functions-in-patients-with-type-2-diabetes-mellitus-a-randomized-controlled-study-comp
#17
https://www.readbyqxmd.com/read/29609804/corrigendum-to-respiration-based-monitoring-of-metabolic-rate-following-cold-exposure-in-two-invasive-anoplophora-species-depending-on-acclimation-regime-comp-biochem-physiol-a-vol-216-2018-20-27
#18
M Javal, A Roques, G Roux, M Laparie
No abstract text is available yet for this article.
May 2018: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/29604278/genetic-overexpression-of-comp-ang1-impairs-bm-microenvironment-and-induces-senescence-of-bm-hscs
#19
Sung-Ho Kook, Hyun-Jaung Sim, Jae-Won Hwang, Young-Hyun Baek, Chun-Chu Kim, Jeong-Hoon Lee, Eui-Sic Cho, Jeong-Chae Lee
Supplemental Angiopoietin 1 (Ang1) exerts its therapeutic potential on microvascular regression-associated diseases, and this potential is linked with the function of hematopoietic stem cells (HSCs). However, the underlying mechanisms of the effect of enhanced angiogenesis on the modulation of HSCs are not yet defined. Here, we generated transgenic mice expressing Cartilage Oligomeric Matrix Protein (COMP)-Ang1 in keratin 14-expressing cells. The mutant animals expressed excessive angiogenic characteristics in the skin and bone marrow (BM) along with redder skin with more numerous and branched vessels compared with their wild-type (WT) littermates...
March 31, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29590493/longitudinal-twin-study-of-subjective-health-differences-in-genetic-and-environmental-components-of-variance-across-age-and-sex
#20
Deborah Finkel, Carol E Franz, Kaare Christensen, Chandra A Reynolds, Nancy L Pedersen
Objective: The current analysis examines sex differences in longitudinal changes in genetic and environmental influences on three measures of subjective health. Method: Sample includes 7372 twins (mean intake age = 73.22) with up to 8 waves of measurement (mean = 3.1). Three subjective health (SH) items were included: general self-rated health (SRH), health compared to age peers (COMP), and impact of health on activities (ACT) which previous research shows capture different frames of reference...
March 24, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
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