keyword
MENU ▼
Read by QxMD icon Read
search

liver cancer

keyword
https://www.readbyqxmd.com/read/29031057/arsenic-speciation-in-fish-and-shellfish-from-the-north-sea-southern-bight-and-a%C3%A3-u-port-area-brazil-and-health-risks-related-to-seafood-consumption
#1
Yue Gao, Paulo Baisch, Nicolai Mirlean, Flavio Manoel Rodrigues da Silva Júnior, Nik Van Larebeke, Willy Baeyens, Martine Leermakers
In North Sea and Port Açu (Brazil) coastal areas, high arsenic (As) concentrations were observed in water, soil and sediments. Therefore, the impact of this contamination on fish and shellfish species bought from local fishermen was studied. Total As was assessed with ICP-OES (Brazil) and ICP-MS (North Sea) after microwave digestion. Toxic As was assessed with liquid chromatography-ICP-MS (Brazil) and hydride generation-atomic fluorescence spectrometry (North Sea). All analytical methods comply with Quality Assurance/Quality Control procedures...
October 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/29028357/folate-peg-nota-al18f-a-new-folate-based-radiotracer-for-pet-imaging-of-folate-receptor-positive-tumors
#2
Qingshou Chen, Xiangjun Meng, Paul McQuade, Daniel Rubins, Shu-An Lin, Zhizhen Zeng, Hyking Haley, Patricia Miller, Dinko Gonzalez Trotter, Philip S Low
The folate receptor (FR) has been established as a promising target for imaging and therapy of cancer (FR-α), inflammation, and autoimmune diseases (FR-β). Several folate-based PET radiotracers have been reported in the literature, but an 18F- labeled folate-PET imaging agent with optimal properties for clinical translation is still lacking. In the present study, we report the design and preclinical evaluation of folate-PEG12-NOTA-Al18F (1), a new folate-PET agent with improved potential for clinical applications...
October 13, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29028096/expressions-of-hif-1%C3%AE-and-kiss-1-in-patients-with-liver-cancer-and-correlation-analysis
#3
W-W Song, A-P Gui, W Li, H-S Chen, J-M Li
OBJECTIVE: To study the expressions of hypoxia-inducible factor-1α (HIF-1α) and tumor metastasis suppressor gene (KISS-1) in patients with liver cancer and to analyze the correlation between HIF-1α and KISS-1 and liver cancer. PATIENTS AND METHODS: 20 normal liver tissues and 30 liver cancer tissues in our hospital were selected. The expressions of HIF-1α and KISS-1 in normal liver tissues and liver cancer tissues were detected via immunofluorescence assay. The mRNA expressions of HIF-1α and KISS-1 in normal liver tissues and liver cancer tissues were detected via reverse transcription polymerase chain reaction (RT-PCR)...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29027980/the-plasticizer-bisphenol-a-perturbs-the-hepatic-epigenome-a-systems-level-analysis-of-the-mirnome
#4
Ludivine Renaud, Willian A da Silveira, E Starr Hazard, Jonathan Simpson, Silvia Falcinelli, Dongjun Chung, Oliana Carnevali, Gary Hardiman
Ubiquitous exposure to bisphenol A (BPA), an endocrine disruptor (ED), has raised concerns for both human and ecosystem health. Epigenetic factors, including microRNAs (miRNAs), are key regulators of gene expression during cancer. The effect of BPA exposure on the zebrafish epigenome remains poorly characterized. Zebrafish represents an excellent model to study cancer as the organism develops a disease that resembles human cancer. Using zebrafish as a systems toxicology model, we hypothesized that chronic BPA-exposure impacts the miRNome in adult zebrafish and establishes an epigenome more susceptible to cancer development...
October 13, 2017: Genes
https://www.readbyqxmd.com/read/29027712/upregulation-of-ube2q1-via-gene-copy-number-gain-in-hepatocellular-carcinoma-promotes-cancer-progression-through-%C3%AE-catenin-egfr-pi3k-akt-mtor-signaling-pathway
#5
Bin Zhang, Chao Deng, Lei Wang, Fan Zhou, Shu Zhang, Wei Kang, Ping Zhan, Juan Chen, Shanshan Shen, Huimin Guo, Ming Zhang, Yi Wang, Feng Zhang, Wei Zhang, Jiangqiang Xiao, Bo Kong, Helmut Friess, Yuzheng Zhuge, Hongli Yan, Xiaoping Zou
Hepatocellular carcinoma (HCC) is the most common type of liver cancer and represents a highly malignant tumor with a poor prognosis. Therapeutic modalities for HCC are limited and generally ineffective. UBE2Q1 is a putative E2 ubiquitin conjugating enzyme, and has been shown to be overexpressed in various types of cancers including HCC. How UBE2Q1 contributes to hepatocarcinogenesis remains unknown. Here, we show that UBE2Q1 is up-regulated in HCC cell lines and in a subset of human HCC tissues. Up-regulation of UBE2Q1 in primary HCC tumors was significantly correlated with shorter overall survival and disease-free survival...
October 13, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29027001/cancer-incidence-in-urban-rural-and-densely-populated-districts-close-to-core-cities-in-bavaria-germany
#6
M Radespiel-Tröger, K Geiss, D Twardella, W Maier, M Meyer
OBJECTIVE: An ecologic study on the level of districts was performed to evaluate the possible association between district type and risk of cancer in Bavaria, Southern Germany. METHODS: Cancer incidence data for the years 2003-2012 were obtained from the population-based cancer registry Bavaria according to sex and cancer site. Data on district type, socio-economic area deprivation, particulate matter exposure, tobacco consumption, and alcohol consumption were obtained from publicly available sources...
October 12, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29026950/the-prognostic-value-of-18-f-fdg-pet-ct-prior-to-liver-transplantation-for-nonresectable-colorectal-liver-metastases
#7
Harald Grut, Svein Dueland, Pål Dag Line, Mona Elisabeth Revheim
PURPOSE: The main objective of this study was to evaluate the prognostic value of volumetric and metabolic information derivied from F-18 fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) in combination with computed tomography (CT) prior to liver transplantation (LT) in patients with nonresectable colorectal liver metastases (CLM). Due to scarcity of liver grafts, prognostic information enabling selection of candidates who will gain the highest survival after LT is of vital importance...
October 12, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29026462/murine-hepatocellular-carcinoma-derived-stem-cells-reveal-epithelial-to-mesenchymal-plasticity
#8
Aparna Jayachandran, Ritu Shrestha, Bijay Dhungel, I-Tao Huang, Marianna Yumi Kawashima Vasconcelos, Brian J Morrison, Charmaine A Ramlogan-Steel, Jason C Steel
AIM: To establish a model to enrich and characterize stem-like cells from murine normal liver and hepatocellular carcinoma (HCC) cell lines and to further investigate stem-like cell association with epithelial-to-mesenchymal transition (EMT). METHODS: In this study, we utilized a stem cell conditioned serum-free medium to enrich stem-like cells from mouse HCC and normal liver cell lines, Hepa 1-6 and AML12, respectively. We isolated the 3-dimensional spheres and assessed their stemness characteristics by evaluating the RNA levels of stemness genes and a cell surface stem cell marker by quantitative reverse transcriptase-PCR (qRT-PCR)...
September 26, 2017: World Journal of Stem Cells
https://www.readbyqxmd.com/read/29026319/current-advances-of-long-non-coding-rna-highly-upregulated-in-liver-cancer-in-human-tumors
#9
REVIEW
Zhonghua Ma, Hesuyuan Huang, Yetao Xu, Xuezhi He, Jirong Wang, Bingqing Hui, Hao Ji, Jing Zhou, Keming Wang
Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs (ncRNAs) >200 nucleotides in length that govern diverse biological processes. Recent evidence suggests that lncRNAs are involved in cancer cell proliferation, apoptosis, invasion, migration, and metastasis. Dysregulation of lncRNAs has been observed in various tumors, and lncRNAs act as oncogenes or tumor suppressors in these malignancies. It has been revealed that lncRNA highly upregulated in liver cancer (HULC) is tightly correlated with a number of cancers such as hepatocellular carcinoma, gastric cancer, colorectal cancer, osteosarcoma, and diffuse large B-cell lymphoma...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29025375/dopamine-induced-sult1a3-4-promotes-emt-and-cancer-stemness-in-hepatocellular-carcinoma
#10
Juan Zou, Hong Li, Qianling Huang, Xiaomin Liu, Xiaoxiao Qi, Ying Wang, Linlin Lu, Zhongqiu Liu
Hepatocellular carcinoma has the second highest incidence rate among malignant cancers in China. Hepatocellular carcinoma development is complex because of the metabolism disequilibrium involving SULT1A3/4, a predominant sulfotransferase that metabolizes sulfonic xenobiotics and endogenous catecholamines. However, the correlation between SULT1A3/4 and hepatocellular carcinoma progression is unclear. By utilizing immunofluorescence and immunohistochemical analysis, we found that in nine hepatocellular carcinoma clinical specimens, SULT1A3/4 was abundantly expressed in tumor tissues compared to that in the adjacent tissues...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29024941/in-depth-proteomic-analysis-of-tissue-interstitial-fluid-for-hepatocellular-carcinoma-serum-biomarker-discovery
#11
Jian Zhang, Ning Hao, Wei Liu, Min Lu, Longqin Sun, Ning Chen, Miantao Wu, Xiaohang Zhao, Baocai Xing, Wei Sun, Fuchu He
BACKGROUND: Hepatocellular carcinoma (HCC) is a primary malignancy of the liver. New serum biomarkers for HCC screening are needed, especially for alpha-fetoprotein (AFP) negative patients. As a proximal fluid between body fluids and intracellular fluid, tissue interstitial fluid (TIF) is a suitable source for serum biomarker discovery. METHODS: Sixteen paired TIF samples from HCC tumour and adjacent non-tumour tissues were analysed by isobaric tags for relative and absolute quantitation (iTRAQ) method...
October 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29024910/leishmanicidal-and-cytotoxic-activity-of-hederagenin-bistriazolyl-derivatives
#12
Diego Rodríguez-Hernández, Luiz C A Barbosa, Antonio J Demuner, Amalyn Nain-Perez, Sebastião R Ferreira, Ricardo T Fujiwara, Raquel M de Almeida, Lucie Heller, René Csuk
Aiming to obtain new potent leishmanicidal and cytotoxic compounds from natural sources, the triterpene hederagenin was converted into several new 1,2,3-triazolyl derivatives tethered at C-23 and C-28. For this work hederagenin was isolated from fruits of Sapindus saponaria and reacted with propargyl bromide to afford as a major product bis-propargylic derivative 1 in 74%. Submitting this compound to Huisgen 1,3-dipolar cycloaddition reactions with several azides afforded the derivatives 2-19 with yields in the range of 40-87%...
September 22, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29024739/direct-antiviral-agents-daas-a-new-age-in-the-treatment-of-hepatitis-c-virus-infection
#13
REVIEW
Ulrich Spengler
Hepatitis C virus (HCV) is a global health problem, because infection frequently leads to chronic hepatitis C eventually progressing to liver cirrhosis and liver cancer. Improved insights into the HCV replication cycle and the role of HCV non-structural proteins has recently enabled to identify drugs directly acting on specific HCV target structures. Agents from three drug classes have been developed and approved by the health authorities. Combinations of two or more drugs from different classes achieve high (>90%) HCV clearance rates and are well tolerated...
October 9, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29024701/dha-and-pgpma-dual-modified-ph-sensitive-polymeric-micelles-for-target-treatment-of-liver-cancer
#14
Haojun Ma
In clinical therapy, the poor prognosis of hepatocellular carcinoma (HCC) is mainly attributed to the failure of chemotherapeutical agents to accumulate in tumor as well as lack of potency of tumor penetration. In this work, we developed actively tumor-targeting micelles with pH-sensitive linker as a novel nanocarrier for HCC therapy. These micelles comprised of biodegradable PEG-pAsp polymers, in which PTX can be covalently conjugated to pAsp via an acid-labile acetal bond to form pH-responsive structures...
October 9, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29024405/current-status-of-liver-transplantation-for-cholangiocarcinoma
#15
REVIEW
Nicolás Goldaracena, Andre Gorgen, Gonzalo Sapisochin
Cholangiocarcinoma (CCA) is the second most common liver cancer and it is associated with a poor prognosis. CCA can be divided into intrahepatic, hilar and distal. Despite the subtype, the median survival is 12-24 months without treatment. Liver transplantation (LT) is worldwide recognized as a curative option for hepatocellular carcinoma. On the other hand, the initial results for LT for CCA were very poor mainly due to a lack of adequate patient selection. In the last two decades, improvement has been made in the management of unresectable hilar CCA, and the results of LT after neoadjuvant chemoradiation have been shown to be promising...
October 11, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29023935/exosome-mir-335-as-a-novel-therapeutic-strategy-in-hepatocellular-carcinoma
#16
Fang Wang, Tian Hongwei, Ling Li, Klaus Piontek, Masazumi Sakaguchi, Florin M Selaru
Hepatocellular Cancer (HCC) is a common and deadly cancer. Most cases of HCC arise in a cirrhotic/fibrotic liver, raising the possibility that the environment plays a paramount role in cancer genesis. Previous studies from our group and others have shown that, in desmoplastic cancers, there is a rich intercellular communication between activated, cancer-associated fibroblasts (CAF) and cancer cells. Moreover, Extracellular Vesicles (EVs), or exosomes, were identified asan important arm of this intercellular communication platform...
October 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29023917/prmt1-and-jmjd6-dependent-arginine-methylation-regulate-hnf4%C3%AE-expression-and-hepatocyte-proliferation
#17
Jie Zhao, Abby Adams, Ben Roberts, Maura O'Neil, Anusha Vittal, Timothy Schmitt, Sean Kumer, Josiah Cox, Zhuan Li, Steven A Weinman, Irina Tikhanovich
Alcohol is a well-established risk factor for hepatocellular carcinoma, but the mechanisms by which it promotes liver cancer are not well understood. Several studies have shown that cellular protein arginine methylation is inhibited by alcohol. Arginine methylation is controlled by the reciprocal activity of protein arginine methyltransferases, primarily PRMT1, and a demethylase JMJD6. The aim of this study was to explore the role of arginine methylation changes in alcohol pathogenesis. We found that PRMT1 activity is inhibited in livers of mice fed with alcohol compared to pair-fed mice...
October 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29023764/liver-diseases-in-adult-life-after-childhood-cancer-in-scandinavia-aliccs-a-population-based-cohort-study-of-32-839-one-year-survivors
#18
Trine Gade Bonnesen, Jeanette F Winther, Klaus K Andersen, Peter H Asdahl, Sofie de Fine Licht, Thorgerdur Gudmundsdottir, Anna Sällfors Holmqvist, Laura-Maria Madanat-Harjuoja, Laufey Tryggvadottir, Finn Wesenberg, Carsten Heilmann, Jørgen H Olsen, Henrik Hasle
Information on late onset liver complications after childhood cancer is scarce. To ensure an appropriate follow-up of childhood cancer survivors and reducing late liver complications, the need for comprehensive and accurate information is presented. We evaluate the risk of liver diseases in a large childhood cancer survivor cohort. We included all one-year survivors of childhood cancer treated in the five Nordic countries. A Cox proportional hazards model was used to estimate hospitalisation rate (hazard) ratios (HRs) for each liver outcome according to type of cancer...
October 11, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29023320/favorable-liver-cancer-mortality-to-incidence-ratios-of-countries-with-high-health-expenditure
#19
Chi-Chih Wang, Ming-Chang Tsai, Cheng-Ming Peng, Hsiang-Lin Lee, Hsuan-Yi Chen, Tzu-Wei Yang, Wen-Wei Sung, Chun-Che Lin
OBJECTIVE: Health expenditure is a marker associated with an advanced healthcare system, which contributes toward the good prognosis of patients. Mortality-to-incidence ratios (MIRs) are one of the predictors that reflect the prognosis of cancer patients. There remains some uncertainty on the correlation of MIRs of liver cancer with the health expenditure of countries. METHODS: We therefore analyzed the correlation of MIRs from the GLOBOCAN 2012 database with the WHO rankings and the total expenditures on health/gross domestic product from WHO by linear regression analyses...
October 11, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29022914/emergence-of-aspirin-as-a-promising-chemopreventive-and-chemotherapeutic-agent-for-liver-cancer
#20
Hongping Xia, Kam M Hui
No abstract text is available yet for this article.
October 12, 2017: Cell Death & Disease
keyword
keyword
789
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"