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https://www.readbyqxmd.com/read/30242345/accuracy-of-the-pediatric-end-stage-liver-disease-score-in-estimating-pretransplant-mortality-among-pediatric-liver-transplant-candidates
#1
Chung-Chou H Chang, Cindy L Bryce, Benjamin L Shneider, Jonathan G Yabes, Yi Ren, Gabriel L Zenarosa, Heather Tomko, Drew M Donnell, Robert H Squires, Mark S Roberts
Importance: Fair allocation of livers between pediatric and adult recipients is critically dependent on the accuracy of mortality estimates afforded by the Pediatric End-stage Liver Disease (PELD) and Model for End-stage Liver Disease, respectively. Widespread reliance on exceptions for pediatric recipients suggests that the 2 systems may not be comparable. Objective: To evaluate the accuracy of the PELD score in estimating 90-day pretransplant mortality among pediatric patients on the United Network for Organ Sharing (UNOS) waiting list...
September 17, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/30242144/expression-of-b-cell-specific-moloney-murine-leukemia-virus-integration-site-1-bmi-1-and-ww-domain-containing-oxidoreductase-wwox-in-liver-cancer-tissue-and-normal-liver-tissue
#2
Jun Yu, Minlan Hu, Wenmei Chen, Zirong Wen
BACKGROUND The aim of this study was to compare the expression levels of mRNA of the B cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) and the WW domain-containing oxidoreductase (WWOX) genes and their protein products in tissues from patients with liver cancer with normal liver tissues from patients without liver cancer. MATERIAL AND METHODS The liver cancer group (N=56) included patients with available tissue samples of histologically confirmed liver cancer. The control group (N=24) included histologically confirmed normal liver tissue samples...
September 22, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30242094/nano-targeted-delivery-of-rad6-translesion-synthesis-inhibitor-for-triple-negative-breast-cancer-therapy
#3
Nadia Saadat, Fangchao Liu, Brittany Haynes, Pratima Nangia-Makker, Xun Bao, Jing Li, Lisa Polin, Smiti Gupta, Guangzhao Mao, Malathy P Shekhar
The triple negative breast cancer (TNBC) subtype regardless of their BRCA1 status has the poorest outcome compared to other breast cancer subtypes and currently there are no approved targeted therapies for TNBC. We have previously demonstrated the importance of Rad6-mediated translesion synthesis pathway in TNBC development/progression and chemoresistance, and the potential therapeutic benefit of targeting Rad6 with a Rad6-selective small molecule inhibitor SMI#9. To overcome SMI#9 solubility limitations, we recently developed a gold nanoparticle (GNP)-based platform for conjugation and intracellular release of SMI#9, and demonstrated its in vitro cytotoxic activity towards TNBC cells...
September 21, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/30242067/the-tumor-microenvironment-drives-liver-cancer-lineage-commitment
#4
(no author information available yet)
The hepatic microenvironment epigenetically directs lineage commitment to promote ICC or HCC liver tumors.
September 21, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/30241999/outcome-of-bariatric-surgery-in-older-patients
#5
Sergio Susmallian, Royi Barnea, Yossi Weiss, Asnat Raziel
BACKGROUND: People are living longer than they were expected to 2 decades ago. Increased life expectancy and reduced mortality encompasses a simultaneous increase in the number of older adults with obesity that entails an increase of co-morbidities, such as diabetes, hypertension, cancer, and many other diseases. The aim of our study was to compare the outcomes of bariatric surgery in patients age ≥65 in comparison with younger patients. METHODS: This retrospective study compares bariatric surgeries performed in a private institution between the years 2013 and 2015...
August 11, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/30241553/mir-203-inhibits-ovarian-tumor-metastasis-by-targeting-birc5-and-attenuating-the-tgf%C3%AE-pathway
#6
Baojin Wang, Xia Li, Guannan Zhao, Huan Yan, Peixin Dong, Hidemichi Watari, Michelle Sims, Wei Li, Lawrence M Pfeffer, Yuqi Guo, Junming Yue
BACKGROUND: We previously reported that miR-203 functions as a tumor suppressor in ovarian cancer cells by directly targeting transcription factor Snai2 and inhibiting epithelial to mesenchymal transition (EMT), whereas BIRC5/survivin promotes EMT. In this study, we tested our hypothesis that miR-203 inhibits ovarian tumor metastasis by suppressing EMT through targeting BIRC5, using an orthotopic ovarian cancer mouse model. METHODS: We overexpressed miR-203 in ovarian cancer SKOV3 and OVCAR3 cells using a lentiviral vector and examined cell migration and invasion using transwell plates...
September 21, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/30241526/proteogenomic-characterization-and-comprehensive-integrative-genomic-analysis-of-human-colorectal-cancer-liver-metastasis
#7
Yu-Shui Ma, Tao Huang, Xiao-Ming Zhong, Hong-Wei Zhang, Xian-Ling Cong, Hong Xu, Gai-Xia Lu, Fei Yu, Shao-Bo Xue, Zhong-Wei Lv, Da Fu
BACKGROUND: Proteogenomic characterization and integrative and comparative genomic analysis provide a functional context to annotate genomic abnormalities with prognostic value. METHODS: Here, we analyzed the proteomes and performed whole exome and transcriptome sequencing and single nucleotide polymorphism array profiling for 2 sets of triplet samples comprised of normal colorectal tissue, primary CRC tissue, and synchronous matched liver metastatic tissue. RESULTS: We identified 112 CNV-mRNA-protein correlated molecules, including up-regulated COL1A2 and BGN associated with prognosis, and four strongest hot spots (chromosomes X, 7, 16 and 1) driving global mRNA abundance variation in CRC liver metastasis...
September 21, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/30241515/peg-l-chop-treatment-is-safe-and-effective-in-adult-extranodal-nk-t-cell-lymphoma-with-a-low-rate-of-clinical-hypersensitivity
#8
Wen Zheng, Yuhuan Gao, Xiaoyan Ke, Weijing Zhang, Liping Su, Hanyun Ren, Ningjing Lin, Yan Xie, Meifeng Tu, Weiping Liu, Lingyan Ping, Zhitao Ying, Chen Zhang, Lijuan Deng, Xiaopei Wang, Yuqin Song, Jun Zhu
BACKGROUND: The combination of chemotherapy and L-asparaginase (L-ASP) treatment significantly increased survival rate in an adult patient with extranodal natural killer (NK)/T-cell lymphoma (NKTCL). However, hypersensitivity reactions of L-ASP in some patients limited its application. Polyethylene glycol-conjugated asparaginase (PEG-ASP) has a lower immunogenicity and longer circulating half-life than unconjugated L-ASP, and has been reported to be effective and well-tolerated in children with acute lymphoblastic leukemia...
September 21, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30241400/metformin-an-old-drug-with-new-applications
#9
REVIEW
Joseph Zhou, Scott Massey, Darren Story, Lixin Li
Metformin is a biguanide drug that has been used to treat type 2 diabetes mellitus for more than 60 years. The United Kingdom Prospective Diabetic Study (UKPDS) has shown metformin to improve mortality rates in diabetes patients, and recent studies suggest metformin has additional effects in treating cancer, obesity, nonalcoholic fatty liver disease (NAFLD), polycystic ovary syndrome (PCOS), and metabolic syndrome. Metformin has also been shown to alleviate weight gain associated with antipsychotic medication...
September 21, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30241269/data-reliability-and-coding-completeness-of-cancer-registry-information-using-reabstracting-method-in-the-national-cancer-institute-thailand-2012-to-2014
#10
Anupong Sirirungreung, Rangsiya Buasom, Chuleeporn Jiraphongsa, Suleeporn Sangrajrang
PURPOSE: Data quality is a core value of cancer registries, which bring about greater understanding of cancer distribution and determinants. Thailand established its cancer registry in 1986; however, studies focusing on data reliability have been limited. This study aimed to assess the coding completeness and reliability of the National Cancer Institute (NCI) hospital-based cancer registry, Thailand. METHODS: This study was conducted using the reabstracting method...
September 2018: Journal of Global Oncology
https://www.readbyqxmd.com/read/30241262/estimates-of-cancer-incidence-in-ethiopia-in-2015-using-population-based-registry-data
#11
Solomon Tessema Memirie, Mahlet Kifle Habtemariam, Mathewos Asefa, Biniyam Tefera Deressa, Getamesay Abayneh, Biniam Tsegaye, Mihiret Woldetinsae Abraha, Girma Ababi, Ahmedin Jemal, Timothy R Rebbeck, Stéphane Verguet
PURPOSE: Noncommunicable diseases, prominently cancer, have become the second leading cause of death in the adult population of Ethiopia. A population-based cancer registry has been used in Addis Ababa (the capital city) since 2011. Availability of up-to-date estimates on cancer incidence is important in guiding the national cancer control program in Ethiopia. METHODS: We obtained primary data on 8,539 patients from the Addis Ababa population-based cancer registry and supplemented by data on 1,648 cancer cases collected from six Ethiopian regions...
September 2018: Journal of Global Oncology
https://www.readbyqxmd.com/read/30241165/advancing-reliable-data-for-cancer-control-in-the-central-america-four-region
#12
Marion Piñeros, Silvina Frech, Lindsay Frazier, Mathieu Laversanne, Joaquin Barnoya, Claudia Garrido, Eduardo Gharzouzi, Andrea Chacón, Soad Fuentes Alabi, Lisseth Ruiz de Campos, Jacqueline Figueroa, Ricardo Dominguez, Ofelia Rojas, Rosario Pereira, Carla Rivera, Douglas R Morgan
The Central America Four (CA-4) region, comprising Guatemala, Honduras, El Salvador, and Nicaragua, is the largest low- and middle-income country region in the Western Hemisphere, with over 36 million inhabitants. The CA-4 nations share a common geography, history, language, and development indices, and unified with open borders in 2006. The growing CA-4 cancer burden among the noncommunicable diseases is expected to increase 73% by 2030, which argues for a regional approach to cancer control. This has driven efforts to establish population-based cancer registries as a central component of the cancer control plans...
September 2018: Journal of Global Oncology
https://www.readbyqxmd.com/read/30240696/selenium-lentinan-inhibits-tumor-progression-by-regulating-epithelial-mesenchymal-transition
#13
Yan-Rong Liu, Bo Sun, Guo-Hong Zhu, Wei-Wei Li, Yi-Xuan Tian, Lu-Meng Wang, Shu-Min Zong, Peng-Zhen Sheng, Meng Li, Shuang Chen, Yuan Qin, Hui-Juan Liu, Hong-Gang Zhou, Tao Sun, Cheng Yang
BACKGROUND: Selenium supplementation can be used to treat tumors. However, inorganic selenium is highly toxic, and natural organic selenium is extremely rare. Polysaccharides can improve drug bioavailability and targeting. Lentinan is a polysaccharide that has been approved as an anti-cancer drug in Japan and China. METHODS: Lentinan, an antitumor polysaccharide extracted from Lentinus edodes, was conjugated with seleninic acid to be transformed into ester (Se-lentinan) and utilized as drug carrier...
September 18, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/30240586/methodological-development-and-biological-observations-of-cell-free-dna-with-a-simple-direct-fluorescent-assay-in-colorectal-cancer
#14
A K Boysen, B S Sørensen, A C Lefevre, R Abrantes, J S Johansen, B V Jensen, J V Schou, F O Larsen, D Nielsen, H Taflin, B Gustavson, Y Wettergren, B S Sorensen, A H Ree, S Dueland, N Pallisgaard, K L Spindler
BACKGROUND: Cell free DNA (cfDNA) has shown promising utility as prognostic biomarker for patients with colorectal cancer (CRC), with an ongoing need to optimize and validate the laboratory methodology. Here, we report our optimization and validation of a direct fluorescent assay and display the potential utility in patients with colorectal cancer. METHODS: Plasma cfDNA was analyzed by a direct fluorescent assay (DFA) and compared to quantification by droplet digital PCR (ddPCR)...
September 18, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/30240398/survival-prediction-among-patients-with-non-cancer-related-end-stage-liver-disease
#15
Yi-Wen Tsai, I-Shiang Tzeng, Yi-Chuan Chen, Tsung-Han Hsieh, Shy-Shin Chang
BACKGROUND: Predicting the survival of non-cancer related end-stage-liver-disease patients in general practice has been difficult for physicians because of the extremely variable trajectories due to multiple complex clinical factors, hence it remains a challenging issue to date. This study aimed to develop and validate a specific prognostic scoring system to early recognize the prognosis and improve the quality of end-of life care for non-cancer end-stage-liver-disease population. MATERIALS AND METHODS: A multicentre, retrospective cohort study was conducted during January 2010 ~ December 2012 and continued follow-up until December 2014...
2018: PloS One
https://www.readbyqxmd.com/read/30239895/the-potent-itk-btk-inhibitor-ibrutinib-is-effective-for-the-treatment-of-experimental-visceral-leishmaniasis-caused-by-leishmania-donovani
#16
Sanjay Varikuti, Greta Volpedo, Noushin Saljoughian, Omar M Hamza, Gregory Halsey, Nathan M Ryan, Bren E Sedmak, Gabriella R Seidler, Tracey L Papenfuss, Steve Oghumu, Abhay R Satoskar
Background: New drugs are needed for leishmaniasis as current treatments such as pentavalent antimonials are toxic and require prolonged administration leading to poor patient compliance. Ibrutinib is an anti-cancer drug known to modulate Th1/Th2 responses, and has the potential to regulate immunity against infectious disease. Methods: In this study, we evaluated the efficacy of oral Ibrutinib as a host-targeted treatment for visceral leishmaniasis (VL) caused by L...
September 15, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/30239845/the-slc-transporter-in-nutrient-and-metabolic-sensing-regulation-and-drug-development
#17
Yong Zhang, Yuping Zhang, Kun Sun, Ziyi Meng, Ligong Chen
The prevalence of metabolic diseases is growing worldwide. Accumulating evidence suggests that solute carrier (SLC) transporters contribute to the aetiology of various metabolic diseases. Consistent with metabolic characteristics, the top 5 organs in which SLC transporters are highly expressed are the kidney, brain, liver, gut, and heart. Our long-term research goals are to understand the molecular mechanisms of important SLC transporter-mediated physiological processes and their potentials as drug targets...
September 18, 2018: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/30239392/mir-486-5p-downregulation-marks-an-early-event-in-colorectal-carcinogenesis
#18
Katherine A Kelley, Nicole Wieghard, Yuki Chin, Amiee Potter, Motomi Mori, Melissa H Wong, Koei Chin, V Liana Tsikitis
BACKGROUND: MicroRNAs are dysregulated in colorectal cancer and subsets correlated with advanced tumor stage and metastasis. Data are lacking on microRNA dysregulation from early to late-stage disease. OBJECTIVE: The purpose of this study was to identify a microRNA signature associated with the primary tumor and metastatic site in stage IV disease and to examine whether the signature is evident in earlier stages. DESIGN: A microRNA profile was generated and then explored in normal colon tissue (n = 5), early stage (stage I and II; n = 10), and late-stage (stage III and IV; n = 14) colorectal primary tumors via polymerase chain reaction to delineate molecular events that may promote colorectal carcinogenesis...
September 19, 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/30238990/teeth-derived-stem-cells-a-source-for-cell-therapy
#19
REVIEW
Ghazaleh Baniebrahimi, Razieh Khanmohammadi, Fatemeh Mir
Cell therapy is one of the important therapeutic approaches in the treatment of many diseases such as cancer, degenerative diseases, and cardiovascular diseases. Among various cell types, which could be used as cell therapies, stem cell therapy has emerged as powerful tools in the treatment of several diseases. Multipotent stem cells are one of the main classes of stem cells that could originate from different parts of the body such as bone marrow, adipose, placenta, and tooth. Among several types of multipotent stem cells, tooth-derived stem cells (TDSCs) are associated with special properties such as accessible, easy isolation, and low invasive, which have introduced them as a good source for using in the treatment of several diseases such as neural injuries, liver fibrosis, and Cohrn's disease...
September 21, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30238748/ultrasensitive-detection-of-serum-microrna-using-branched-dna-based-sers-platform-combining-simultaneous-detection-of-%C3%AE-fetoprotein-for-early-diagnosis-of-liver-cancer
#20
Linxiu Cheng, Zhikun Zhang, Duo Zuo, Wenfeng Zhu, Jie Zhang, Qingdao Zeng, Dayong Yang, Min Li, Yuliang Zhao
We provided an ultrasensitive sensing strategy for microRNA detection by firstly employing branched DNA. With the aid of micro-contact printing, we realized the multiplex sensing of different kinds of liver cancer biomarkers: microRNA and protein, simultaneously. Delicately designed branched-DNA included multiple complementary sticky-ends as probe to microRNA capture and the double-stranded rigid branched core to increase active sticky-ends distance and expose more DNA probes for sensitivity. The branched-DNA enables 2 orders of magnitude increase in sensitivity for microRNA detection over single-stranded DNA...
September 21, 2018: ACS Applied Materials & Interfaces
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