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https://www.readbyqxmd.com/read/29475053/exploring-the-role-of-cellular-homologous-of-the-30k-superfamily-of-plant-virus-movement-proteins
#1
José L Carrasco, Jesús A Sánchez-Navarro, Santiago F Elena
Genes orthologous to the 30K-superfamily of movement proteins (MP) from plant viruses have been recently discovered by bioinformatics analyses as integrated elements in the genome of most vascular plants. However, their functional relevance for plants is still unclear. Here, we undertake some preliminary steps into the functional characterization of one of these putative MP genes found in Arabidopsis thaliana. We found that the AtMP gene is expressed at different stages of the plant development, with accumulation being highest in flowers but lowest in mature siliques...
February 20, 2018: Virus Research
https://www.readbyqxmd.com/read/29474413/effects-of-earthquake-on-perinatal-outcomes-a-chilean-register-based-study
#2
Yasna K Palmeiro-Silva, Pelusa Orellana, Pia Venegas, Lara Monteiro, Manuel Varas-Godoy, Errol Norwitz, Gregory Rice, Eduardo Osorio, Sebastián E Illanes
BACKGROUND: Natural disasters increase the level population stress, including pregnant women, who can experience prenatal maternal stress, affecting the fetus and triggering perinatal complications, such as low birth weight, smaller head circumference, etc. However, little is known about effects of earthquake on perinatal outcomes. OBJECTIVE: To evaluate the effect of earthquake occurred on February 27, 2010 and perinatal outcomes of Chilean pregnant women, and to examine these effects by timing of exposure during pregnancy and newborn gender...
2018: PloS One
https://www.readbyqxmd.com/read/29474203/association-of-renin-angiotensin-system-genes-polymorphisms-and-risk-of-premature-st-elevation-myocardial-infarction-in-young-mexican-population
#3
Irma Isordia-Salas, José A Alvarado-Moreno, Rosa M Jiménez-Alvarado, Jesús Hernández-Juárez, David Santiago-Germán, Alfredo Leaños-Miranda, Abraham Majluf-Cruz
: The renin-angiotensin system plays an important role in the regulation of blood pressure and the development of coronary artery disease. The aim was to examine the association of the insertion deletion in the angiotensin-converting enzyme gene, M235T and T174M polymorphisms in the angiotensinogen gene with ST elevation acute myocardial infarction (STEAMI) in young Mexican population. We analyzed 242 unrelated patients with STEAMI 45 or less years of age, admitted to a cardiovascular intense care unit, and 242 individuals without STEAMI matched by age and sex, recruited from January 2006 and June 2013...
February 22, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29473656/%C3%AE-synuclein-snca-but-not-dynamin-3-dnm3-influences-age-at-onset-of-leucine-rich-repeat-kinase-2-lrrk2-parkinson-s-disease-in-spain
#4
Rubén Fernández-Santiago, Alicia Garrido, Jon Infante, Isabel González-Aramburu, María Sierra, Manel Fernández, Francesc Valldeoriola, Esteban Muñoz, Yaroslau Compta, María-José Martí, José Ríos, Eduardo Tolosa, Mario Ezquerra
OBJECTIVES: A recent study showed that Arab-Berbers GG homozygous at rs2421947(C/G) in the dynamin 3 gene (DNM3) had 12.5 years earlier age at onset of leucine-rich repeat kinase 2 (LRRK2)-associated Parkinson's disease (PD) (L2PD). We explored whether this variant modulates the L2PD age at onset in Spain. METHODS: We genotyped rs2421947 in 329 participants (210 L2PD patients, 119 L2PD nonmanifesting p.G2019S carriers), and marker rs356219 (A/G) in the α-synuclein gene (SNCA)...
February 23, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29473047/familial-monophasic-acute-transverse-myelitis-due-to-the-pathogenic-variant-in-vps37a
#5
Maureen A Mealy, Tai-Seung Nam, Santiago J Pardo, Carlos A Pardo, Nara L Sobreira, Dimitrios Avramopoulos, David Valle, Kathleen H Burns, Michael Levy
Objective: To identify genetic differences among siblings with a family history of idiopathic transverse myelitis (ITM). Methods: We compared whole-exome sequencing (WES) on germline samples from the 2 affected sisters with ITM with 3 of their healthy siblings. Results: The 2 sisters with ITM both had acute onset of sensory loss in the legs, weakness, and bowel/bladder dysfunction. The first developed ITM at age 15 years with a clinical nadir of complete paralysis, which slowly recovered over a few years...
February 2018: Neurology. Genetics
https://www.readbyqxmd.com/read/29472382/dopamine-d2-receptor-up-regulates-leptin-and-il-6-in-adipocytes
#6
Xiaoyan Wang, Van A Villar, Andrew Tiu, Kiran K Upadhyay, Santiago Cuevas
Leptin is a pro-inflammatory cytokine secreted by the adipose tissue. Dopamine D2 receptors (D2R) have anti-inflammatory effects in the brain and kidney tissues. Mouse and human adipocytes express the (D2R); D2R protein was 10-fold greater in adipocytes from human visceral than subcutaneous tissue. However, the function of D2R in adipocytes is not well understood. The D2-like receptor agonist Quinpirole increased the protein expression of leptin and IL-6, not adiponectin and Visfatin, along with their mRNA expression (24 hr)...
February 22, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29472118/loss-of-heterozygosity-of-mir15a-mir16-1-negative-regulators-of-the-antiapoptotic-gene-bcl2-is-not-common-in-odontogenic-keratocysts
#7
Taynara Asevedo Campos de Resende, Vanessa de Fátima Bernardes, Jéssica Carolina da Silva, Luiz Armando De Marco, Ricardo Santiago Gomez, Carolina Cavalieri Gomes, Marina Gonçalves Diniz
OBJECTIVES: The odontogenic keratocyst (OKC) is an aggressive odontogenic cyst that has a high recurrence rate. Apart from PTCH1 mutations, few molecular alterations are described in OKCs. Low expression of microRNAs (miRNAs) miR-15a and/or miR-16-1 in association with increased expression of their target, Bcl-2, have been previously found in OKC. In humans, MIR15A and MIR16-1 are clustered at chromosome position 13 q14, and loss of heterozygosity (LOH) at this locus occurs in different tumors...
January 31, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29471977/effects-of-parity-on-productive-reproductive-metabolic-and-hormonal-responses-of-holstein-cows
#8
Jéssica Tatiana Morales Piñeyrúa, Santiago Rafael Fariña, Alejandro Mendoza
The objective of this study was to determine the effects that parity may have on production, reproduction and the metabolic status of Holstein cows managed in a production system based on total mixed ration and pasture. Primiparous (n = 22) and multiparous (n = 24) cows from a dairy farm research station in Uruguay were used in a completely randomized design. Body weight (BW), body condition score (BCS) and backfat thickness (BFT) were recorded weekly from -30 to 70 days postpartum. Milk production was measured daily, and milk composition was determined weekly...
February 2, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29471223/indirect-calculation-of-monoclonal-antibodies-in-nanoparticles-using-the-radiolabeling-process-with-technetium-99-metastable-as-primary-factor-alternative-methodology-for-the-entrapment-efficiency
#9
Edward Helal-Neto, Santiago Sánchez Cabezas, Félix Sancenón, Ramón Martínez-Máñez, Ralph Santos-Oliveira
The use of monoclonal antibodies (Mab) in the current medicine is increasing. Antibody-drug conjugates (ADCs) represents an increasingly and important modality for treating several types of cancer. In this area, the use of Mab associated with nanoparticles is a valuable strategy. However, the methodology used to calculate the Mab entrapment, efficiency and content is extremely expensive. In this study we developed and tested a novel very simple one-step methodology to calculate monoclonal antibody entrapment in mesoporous silica (with magnetic core) nanoparticles using the radiolabeling process as primary methodology...
February 13, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29471000/relationship-between-cerebrospinal-fluid-concentrations-of-orexin-a-hypocretin-1-and-body-composition-in-humans
#10
João C P Santiago, Markus Otto, Werner Kern, Paul Christian Baier, Manfred Hallschmid
The hypothalamic neuropeptide orexin A (hypocretin-1) is a key signal in sleep/wake regulation and promotes food intake. We investigated the relationship between cerebrospinal fluid orexin A concentrations and body composition in non-narcoleptic human subjects with a wide range of body weight to gain insight into the role of orexin A in human metabolism. We collected cerebrospinal fluid and blood samples and measured body composition by bioelectric impedance analysis in 36 subjects (16 women and 20 men) with body mass indices between 16...
February 19, 2018: Peptides
https://www.readbyqxmd.com/read/29470164/external-quality-assessment-for-zika-virus-molecular-diagnostic-testing-brazil
#11
Carlo Fischer, Celia Pedroso, Alfredo Mendrone, Ana Maria Bispo de Filippis, Antonio Carlos Rosário Vallinoto, Bergmann Morais Ribeiro, Edison Luiz Durigon, Ernesto T A Marques, Gubio S Campos, Isabelle F T Viana, José Eduardo Levi, Luciano Cesar Scarpelli, Mauricio Lacerda Nogueira, Michele de Souza Bastos, Nathalia C Santiago Souza, Ricardo Khouri, Sanny Lira, Shirley Vasconcelos Komninakis, Cécile Baronti, Rémi N Charrel, Beate M Kümmerer, Christian Drosten, Carlos Brites, Xavier de Lamballerie, Matthias Niedrig, Eduardo Martins Netto, Jan Felix Drexler
We conducted an external quality assessment of Zika virus molecular diagnostic tests in Brazil using a new Zika virus standard. Of 15 laboratories, 73% showed limited sensitivity and specificity. Viral load estimates varied significantly. Continuous quality assurance is needed to adequately estimate risk for Zika virus-associated disease and determine patient care.
May 17, 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29469789/paquidermodactilia-engrosamiento-digital-proximal-pachydermodactyly-digital-proximal-thickening
#12
Israel Pérez-López, Antonio Martínez-López, Juan Antonio Retamero, Francisco Gallo, Salvador Arias-Santiago
We report a case of pachydermodactyly (PDD). PDD is a benign, asymptomatic soft tissue swelling affecting the skin of the lateral aspects of the proximal interphalangeal joints of the fingers, mostly in young adolescent males. It has often been interpreted as a consequence of tic-like behavior as part of an obsessive-compulsive disorder. Although the diagnosis is essentially clinical, skin biopsy shows compact orthokeratotic hyperkeratosis, increased numbers of collagen fibers and fibroblasts, and no inflammatory changes...
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469053/fontan-associated-liver-disease-a-review
#13
Luis Téllez, Enrique Rodríguez-Santiago, Agustín Albillos
Fontan-associated liver disease is a hepatic disorder arising from hemodynamic changes and systemic venous congestion following Fontan surgery. The histological changes produced in the liver are similar but not equivalent to those seen in other forms of cardiac liver disease. While the natural history of this form of liver disease is not well established, over time many Fontan patients develop portal hypertension-related complications such as ascites, variceal hemorrhage or encephalopathy. Fontan survivors also show an increased risk of hepatocellular carcinoma...
March 1, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29468545/immunohistochemical-detection-of-retinoblastoma-protein-phosphorylation-in-human-tumor-samples
#14
Jaileene Pérez-Morales, Angel Núñez-Marrero, Pedro G Santiago-Cardona
The retinoblastoma protein (pRb) is an important tumor suppressor and cell cycle repressor. pRb is a phosphoprotein whose function is regulated primarily at the level of phosphorylation, and therefore, detecting pRb's phosphorylation status in human tissue samples can be clinically informative. Unfortunately, detection of phosphorylated pRb residues can be technically challenging, as these residues can often be weak antigens. In this chapter, we describe an enhanced sensitivity immunohistochemistry protocol for the staining of phosphorylated serine 249 in pRb, in human lung tumor samples...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29468543/detection-of-retinoblastoma-protein-phosphorylation-by-immunoblot-analysis
#15
Pedro G Santiago-Cardona, Jaileene Pérez-Morales, Jonathan González-Flores
The retinoblastoma tumor suppressor protein (pRb) is a preeminent tumor suppressor that acts as a cell cycle repressor, specifically as an inhibitor of the G1-S transition of the cell cycle . pRb is a phosphoprotein whose function is repressed by extensive phosphorylation in several key residues, and therefore, pRb's phosphorylation status has become a surrogate for pRb activity. In particular, hyperphosphorylation of pRb has been associated with pathological states such as cancer, and therefore, assessing pRb's phosphorylation status is increasingly gaining diagnostic and prognostic value, may be used to inform therapeutic decisions, and is also an important tool for the cancer biologists seeking an understanding of the molecular etiology of cancer...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29466515/individual-deprivation-regional-deprivation-and-risk-for-oral-clefts-in-argentina
#16
Mariela Soledad Pawluk, Hebe Campaña, Monica Rittler, Fernando Adrián Poletta, Viviana R Cosentino, Juan Antonio Gili, Lucas Gabriel Gimenez, Jorge Santiago López Camelo
OBJECTIVE: The aim of this study was to analyze the effects of individual low socioeconomic status (SES) and deprived geographical area (GA) on the occurrence of isolated cleft lip with or without cleft palate (CL±P) in Argentina. METHODS: This case-control study included 577 newborns with isolated CL±P and 13 344 healthy controls, born between 1992 and 2001, from a total population of 546 129 births in 39 hospitals in Argentina. Census data on unsatisfied basic needs were used to establish the degree of geographical area deprivation...
February 19, 2018: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/29466279/examination-of-behavioral-social-and-environmental-contextual-influences-on-sexually-transmitted-infections-in-at-risk-urban-adolescents-and-young-adults
#17
Cherrie B Boyer, Olga J Santiago Rivera, Danielle M Chiaramonte, Jonathan M Ellen
BACKGROUND: Despite the large body of extant literature on sexually transmitted infections (STIs) in adolescents and young adults (AYAs), more research on social and environmental contextual factors is needed. Also, further examination of STI indicators by gender remains a critical area of research focus. METHODS: Anonymous survey data were collected using ACASIs in community venues in urban, low-income, STI prevalent, U.S. neighborhoods to reach AYAs, aged 12-24 years...
February 21, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29465257/investigational-drugs-in-development-to-prevent-neuromyelitis-optica-relapses
#18
Friedemann Paul, Olwen Murphy, Santiago Pardo, Michael Levy
In the short time since 2014, three pivotal, worldwide studies in neuromyelitis optica spectrum disorders have been launched: eculizumab, SA237 and inebelizumab, each based on a unique mechanism. Areas covered: In this review, we provide a discussion on the trial data available for each drug, a brief description of the trial design, and our expert opinion on the potential benefits and risks. Expert Opinion: Eculizumab, a C5 complement inhibitor, may prove useful in the treatment of intractable cases of NMOSD, but physicians must be aware of the known risk of meningococcal infection...
February 21, 2018: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29464921/design-and-objectives-of-the-south-american-youth-child-cardiovascular-and-environmental-saycare-study
#19
Heráclito Barbosa Carvalho, Luis Alberto Moreno, Andrew Mello Silva, Gabriela Berg, Alejandro Estrada-Restrepo, Laura Inés González-Zapata, Pilar De Miguel-Etayo, Carlos Alberto Delgado, María Isabel Bove, Maria da Luz Rosario de Sousa, Francisco Leonardo Torres-Leal, Claudia L M Forjaz, Augusto César Ferreira De Moraes
OBJECTIVE: The purpose of this paper is to introduce the overarching study design of the South American Youth/Child Cardiovascular and Environmental (SAYCARE) study, which is an observational multicenter feasibility study held in seven South American cities: Buenos Aires (Argentina), Lima (Peru), Medellin (Colombia), Montevideo (Uruguay), Santiago (Chile), and São Paulo and Teresina (Brazil). Children and adolescents (3-17 years of age) were studied. METHODS: The data management systems, quality assurance monitoring activities, standardized operating procedure manuals, and training and study management are addressed in this paper...
March 2018: Obesity
https://www.readbyqxmd.com/read/29464920/development-of-a-food-frequency-questionnaire-for-assessing-dietary-intake-in-children-and-adolescents-in-south-america
#20
Luisa Saravia, Laura I González-Zapata, Tara Rendo-Urteaga, Jamile Ramos, Tatiana Sadalla Collese, Isabel Bove, Carlos Delgado, Florencia Tello, Iris Iglesia, Ederson Dassler Gonçalves Sousa, Augusto César Ferreira De Moraes, Heráclito Barbosa Carvalho, Luis A Moreno
OBJECTIVE: This study aimed to describe the development of a food frequency questionnaire (FFQ) to assess dietary intake in South American children and adolescents. METHODS: A total of 345 children (aged 3-10 years) and 357 adolescents (aged 11-17 years) were included for analysis. The FFQ was designed to be self-administered and to assess dietary intake over the past 3 months. It was developed in Spanish and translated into Portuguese. Multiple approaches were considered to compile the food list, and 11 food groups were included...
March 2018: Obesity
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