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https://www.readbyqxmd.com/read/29035945/the-functional-consequences-of-the-microbiome-in-hiv-insights-from-metabolomic-studies
#1
Sergio Serrano-Villar, Santiago Moreno, Manuel Ferrer
PURPOSE OF REVIEW: It is critical to gain insight into the metabolic pathways by which the microbiota might influence HIV immunopathogenesis to exploit host-microbiota interactions. The aim of this review is to sketch a very broad picture of recent advances in our knowledge of how HIV might affect the microbiota, with a focus on specific gene products, particularly, metabolites produced by the microbiota that may affect HIV immunopathogenesis. RECENT FINDINGS: First, we describe the different approaches used to explore imbalances in effector microbial products during HIV infection...
October 14, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29035823/ratiometric-drug-delivery-using-non-liposomal-nanocarriers-as-an-approach-to-increase-efficacy-and-safety-of-combination-chemotherapy
#2
REVIEW
Marina Santiago Franco, Mônica Cristina Oliveira
The observation that different drug ratios of the same drug combination can lead to synergistic or antagonistic effects when tested against the same cancer cell line in vitro gave rise to a new trend, the ratiometric delivery. This strategy consists of co-encapsulating a specific synergistic ratio of a drug combination into a nanocarrier so that synergism observed in vitro will be faithfully translated to in vivo, optimizing combination therapy. In this review we focus on how to quantify synergism in vitro, followed by how this affected the evolution of nanocarriers culminating in the ratiometric delivery, and finally we summarize the results of the non-liposomal formulations that were built upon this concept...
October 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29035810/traditional-bullying-and-cyberbullying-differences-in-emotional-problems-and-personality-are-cyberbullies-more-machiavellians
#3
Santiago Resett, Manuel Gamez-Guadix
Few studies have examined differences in emotional problems and personality of traditional bullies and cyberbullies. The present study aimed to determine whether those engaged in cyberbullying differ in emotional problems, and personality from those engage in traditional bullying perpetration. An Argentinean sample of 898 high school students was recruited (56% female; mean age = 15.2 SD = 1.6). Adolescents completed measures of traditional bullying, cyberbullying, self-esteem, anxiety, depression, and personality...
October 13, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/29035600/effect-of-the-pacing-strategies-on-the-open-water-10km-world-swimming-championships-performances
#4
Luis Rodriguez, Santiago Veiga
PURPOSE: The aim of the present research was 1) to compare the pacing strategies of different level open water swimmers during the 10km race of the FINA 2015 World Swimming Championships (WCH), and 2) to relate these pacing strategies to the race performance. METHODS: Final and intermediate split times as well as intermediate race positions from the 10-kilometer race participants (69 men and 51 women) were collected from the public domain and were divided into five groups (G1 to G5) depending on their finishing positions...
October 16, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29035419/band-gap-engineering-of-halogenated-silicon-nanowires-through-molecular-doping
#5
Francisco de Santiago, Alejandro Trejo, Alvaro Miranda, Eliel Carvajal, Luis Antonio Pérez, Miguel Cruz-Irisson
In this work, we address the effects of molecular doping on the electronic properties of fluorinated and chlorinated silicon nanowires (SiNWs), in comparison with those corresponding to hydrogen-passivated SiNWs. Adsorption of n-type dopant molecules on hydrogenated and halogenated SiNWs and their chemisorption energies, formation energies, and electronic band gap are studied by using density functional theory calculations. The results show that there are considerable charge transfers and strong covalent interactions between the dopant molecules and the SiNWs...
October 16, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29034951/a-nanocrystal-based-formulation-improves-the-pharmacokinetic-performance-and-therapeutic-response-of-albendazole-in-dogs
#6
Alejandro Javier Paredes, Nicolás Litterio, Alicia Dib, Daniel Alberto Allemandi, Carlos Lanusse, Sergio Sánchez Bruni, Santiago Daniel Palma
OBJECTIVES: Here, we aimed to assess the pharmacokinetic performance and therapeutic response (anthelmintic efficacy) of an albendazole (ABZ) nano-sized formulation in dogs. METHODS: In the pharmacokinetic study, ABZ self-dispersible nanocrystals (SDNCS) and a control formulation were administered orally to healthy dogs (n = 6). The concentrations of the sulphoxide metabolite in plasma were determined by high-performance liquid chromatography. For the anthelmintic efficacy trial, SDNCS and a commercially available formulation of ABZ were given to naturally parasitised dogs...
October 16, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29033897/evaluation-of-cardiometabolic-parameters-among-obese-women-using-oral-contraceptives
#7
Júnia Raquel Dutra Ferreira, Milena Magalhães Aleluia, Camylla Vilas Boas Figueiredo, Larissa Castro de Lima Vieira, Rayra Pereira Santiago, Caroline Conceição da Guarda, Cynara Gomes Barbosa, Ricardo Riccio Oliveira, Elisângela Vitória Adorno, Marilda de Souza Gonçalves
BACKGROUND: Combined oral contraceptive (COC) use has been associated with an unfavorable impact on carbohydrate and lipid metabolism in diverse populations of normal weight and obese women. The present study aimed to evaluate the cardiometabolic and inflammatory profiles of women in northeastern Brazil with respect to COC use and obesity. METHODS: We performed a cross-sectional study to verify cardiovascular parameters, including blood pressure (BP), fasting serum glucose, lipid, and inflammatory profile, in a population of women aged 15-45 years, considering obesity and COC use...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29033695/sexual-health-knowledge-and-stigma-in-a-community-sample-of-hiv-positive-gay-bisexual-and-other-men-who-have-sex-with-men-in-puerto-rico
#8
Edgardo J Ortiz-Sánchez, Carlos E Rodríguez-Díaz, Gerardo G Jovet-Toledo, Edda I Santiago-Rodríguez, Ricardo L Vargas-Molina, Scott D Rhodes
Gay, bisexual and other men who have sex with men (GBMSM) are at increased risk for HIV infection and disease progression. Also, HIV-positive GBMSM are among those less likely to be retained in care. In this study we analyzed sexual health knowledge (SHK) and various manifestations of stigma in a community sample of HIV-positive GBMSM in Puerto Rico. The sample reports overall low SHK scores, and lower score were associated with low educational attainment, unemployment, low income, and with self-identifying heterosexual participants...
2017: Journal of HIV/AIDS & Social Services
https://www.readbyqxmd.com/read/29032689/characterization-and-degradation-of-pectic-polysaccharides-in-cocoa-pulp
#9
Esther Meersman, Nore Struyf, Clare Kyomugasho, Zahra Jamsazzadeh Kermani, Jihan Santanina Santiago, Eline Baert, Sami Hemdane, Gino Vrancken, Kevin J Verstrepen, Christophe M Courtin, Marc Hendrickx, Jan Steensels
Microbial fermentation of the viscous pulp surrounding cocoa beans is a crucial step in chocolate production. During this process, the pulp is degraded, after which the beans are dried and shipped to factories for further processing. Despite its central role in chocolate production, pulp degradation, which is assumed to be a result of pectin breakdown, has not been thoroughly investigated. Therefore, this study provides a comprehensive physicochemical analysis of cocoa pulp, focusing on pectic polysaccharides, and the factors influencing its degradation...
October 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29032608/microrna-profiling-reveals-dysregulated-micrornas-and-their-target-gene-regulatory-networks-in-cemento-ossifying-fibroma
#10
Thaís Dos Santos Fontes Pereira, João Artur Ricieri Brito, André Luiz Sena Guimarães, Carolina Cavaliéri Gomes, Júlio Cesar Tanos de Lacerda, Wagner Henriques de Castro, Roney Santos Coimbra, Marina Gonçalves Diniz, Ricardo Santiago Gomez
BACKGROUND: Cemento-ossifying fibroma (COF) is a benign fibro-osseous neoplasm of uncertain pathogenesis and its treatment results morbidity. MicroRNAs (miRNA) are small non-coding RNAs that regulate gene expression and may represent therapeutic targets. The purpose of the study was to generate a comprehensive miRNA profile of COF compared to normal bone. Additionally, the most relevant pathways and target genes of differentially expressed miRNA were investigated by in silico analysis...
October 15, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29031890/changing-perspectives-in-atopic-dermatitis
#11
REVIEW
E Serra-Baldrich, J O de Frutos, I Jáuregui, J C Armario-Hita, J F Silvestre, L Herraez, A Martín-Santiago, A Valero, J Sastre
Atopic dermatitis (AD) is a multifaceted disease that involves a complex interplay between the skin and the immune system. The course of the disease depends strongly on the genetic background of the patient and on yet poorly-defined environmental factors. Changes in lifestyle could be behind the dramatic rise in the prevalence of AD across continents; including hygienic conditions, food, social habits, skin microbiome or exposure to a number of allergens. Although AD typically develops in childhood and disappears after a few years, in a relatively large number of patients it continues into adulthood...
October 11, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29029236/first-in-human-experience-with-complete-integration-of-neuromodulation-device-within-a-customized-cranial-implant
#12
Chad R Gordon, Gabriel F Santiago, Judy Huang, Gregory K Bergey, Shuya Liu, Mehran Armand, Henry Brem, William S Anderson
BACKGROUND: Neuromodulation devices have the potential to transform modern day treatments for patients with medicine-resistant neurological disease. For instance, the NeuroPace System (NeuroPace Inc, Mountain View, California) is a Food and Drug Administration (FDA)-approved device developed for closed-loop direct brain neurostimulation in the setting of drug-resistant focal epilepsy. However, current methods require placement either above or below the skull in nonanatomic locations. This type of positioning has several drawbacks including visible deformities and scalp pressure from underneath leading to eventual wound healing difficulties, micromotion of hardware with infection, and extrusion leading to premature explantation...
October 6, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29028016/measuring-the-electromagnetic-chirality-of-2d-arrays-under-normal-illumination
#13
X Garcia-Santiago, S Burger, C Rockstuhl, I Fernandez-Corbaton
We present an electromagnetic chirality measure for 2D arrays of subwavelength periodicities under normal illumination. The calculation of the measure uses only the complex reflection and transmission coefficients from the array. The measure allows the ordering of arrays according to their electromagnetic chirality, which further allows a quantitative comparison of different design strategies. The measure is upper bounded, and the extreme properties of objects with high values of electromagnetic chirality make them useful in both near- and far-field applications...
October 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29027792/multifunctional-cytochrome-c-learning-new-tricks-from-an-old-dog
#14
Damián Alvarez-Paggi, Luciana Hannibal, María A Castro, Santiago Oviedo-Rouco, Veronica Demicheli, Veronica Tórtora, Florencia Tomasina, Rafael Radi, Daniel H Murgida
Cytochrome c (cyt c) is a small soluble heme protein characterized by a relatively flexible structure, particularly in the ferric form, such that it is able to sample a broad conformational space. Depending on the specific conditions, interactions, and cellular localization, different conformations may be stabilized, which differ in structure, redox properties, binding affinities, and enzymatic activity. The primary function is electron shuttling in oxidative phosphorylation, and is exerted by the so-called native cyt c in the intermembrane mitochondrial space of healthy cells...
October 13, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/29027176/analysis-of-chip-seq-data-in-r-bioconductor
#15
Ines de Santiago, Thomas Carroll
The development of novel high-throughput sequencing methods for ChIP (chromatin immunoprecipitation) has provided a very powerful tool to study gene regulation in multiple conditions at unprecedented resolution and scale. Proactive quality-control and appropriate data analysis techniques are of critical importance to extract the most meaningful results from the data. Over the last years, an array of R/Bioconductor tools has been developed allowing researchers to process and analyze ChIP-seq data. This chapter provides an overview of the methods available to analyze ChIP-seq data based primarily on software packages from the open-source Bioconductor project...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29026001/understanding-a-role-for-hypoxia-in-lesion-formation-and-location-in-the-deep-and-periventricular-white-matter-in-small-vessel-disease-and-multiple-sclerosis
#16
REVIEW
Santiago Martinez Sosa, Kenneth J Smith
The deep and periventricular white matter is preferentially affected in several neurological disorders, including cerebral small vessel disease (SVD) and multiple sclerosis (MS), suggesting that common pathogenic mechanisms may be involved in this injury. Here we consider the potential pathogenic role of tissue hypoxia in lesion development, arising partly from the vascular anatomy of the affected white matter. Specifically, these regions are supplied by a sparse vasculature fed by long, narrow end arteries/arterioles that are vulnerable to oxygen desaturation if perfusion is reduced (as in SVD, MS and diabetes) or if the surrounding tissue is hypoxic (as in MS, at least)...
October 15, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29024256/transgenerational-plasticity-and-climate-change-experiments-where-do-we-go-from-here
#17
REVIEW
Jennifer M Donelson, Santiago Salinas, Philip L Munday, Lisa N S Shama
Phenotypic plasticity, both within and across generations, is an important mechanism that organisms use to cope with rapid climate change. While an increasing number of studies show that plasticity across generations (transgenerational plasticity or TGP) may occur, we have limited understanding of key aspects of TGP, such as the environmental conditions that may promote it, its relationship to within-generation plasticity (WGP) and its role in evolutionary potential. In this review, we consider how the detection of TGP in climate change experiments is affected by the predictability of environmental variation, as well as the timing and magnitude of environmental change cues applied...
October 12, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29023989/impact-of-contact-lens-material-and-design-on-the-ocular-surface
#18
Javier Ruiz-Alcocer, Daniel Monsálvez-Romín, Santiago García-Lázaro, César Albarrán-Diego, José Luis Hernández-Verdejo, David Madrid-Costa
BACKGROUND: To evaluate the impact on the ocular surface of a daily disposable hydrogel contact lens with high water content compared with two silicone hydrogel daily disposable lenses of lower water content. METHODS: The hydrogel lens assessed was made from nesofilcon A and the silicone hydrogel lenses were made of delefilcon A and stenfilcon A. Contact lens thickness was measured to assess material stability during daily wear, and ocular surface parameters such as tear film osmolarity, tear meniscus area and central corneal thickness were also assessed...
October 11, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29023418/association-between-stress-and-the-hpa-axis-in-the-atopic-dermatitis
#19
REVIEW
Tzu-Kai Lin, Lily Zhong, Juan Luis Santiago
The hypothalamic-pituitary-adrenal (HPA) axis is one of the body's neuroendocrine networks that responds to psychological stress (PS). In the skin, there exists a peripheral HPA axis similar to the central axis. Glucocorticoids (GCs) are key effector molecules of the HPA axis and are essential for cutaneous homeostasis. Atopic dermatitis (AD) is a condition typically characterized by a chronic relapsing course that often results in PS. HPA dysfunction is present in AD patients by the decreased response of GCs elevation to stress as compared to those unaffected by AD...
October 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29022722/the-impact-of-negative-affect-on-attention-patterns-to-threat-across-the-first-2-years-of-life
#20
Koraly Pérez-Edgar, Santiago Morales, Vanessa LoBue, Bradley C Taber-Thomas, Elizabeth K Allen, Kayla M Brown, Kristin A Buss
The current study examined the relations between individual differences in attention to emotion faces and temperamental negative affect across the first 2 years of life. Infant studies have noted a normative pattern of preferential attention to salient cues, particularly angry faces. A parallel literature suggests that elevated attention bias to threat is associated with anxiety, particularly if coupled with temperamental risk. Examining the emerging relations between attention to threat and temperamental negative affect may help distinguish normative from at-risk patterns of attention...
October 12, 2017: Developmental Psychology
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