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https://www.readbyqxmd.com/read/28653242/variables-affecting-the-internal-energy-of-peptide-ions-during-separation-by-differential-ion-mobility-spectrometry
#1
Brandon G Santiago, Matthew T Campbell, Gary L Glish
Differential ion mobility spectrometry (DIMS) devices separate ions on the basis of differences in ion mobility in low and high electric fields, and can be used as a stand-alone analytical method or as a separation step before further analysis. As with other ion mobility separation techniques, the ability of DIMS separations to retain the structural characteristics of analytes has been of concern. For DIMS separations, this potential loss of ion structure originates from the fact that the separations occur at atmospheric pressure and the ions, during their transit through the device, undergo repeated collisions with the DIMS carrier gas while being accelerated by the electric field...
June 26, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28652684/laser-plasmas-in-the-relativistic-transparency-regime-science-and-applications
#2
Juan C Fernández, D Cort Gautier, Chengkung Huang, Sasikumar Palaniyappan, Brian J Albright, Woosuk Bang, Gilliss Dyer, Andrea Favalli, James F Hunter, Jacob Mendez, Markus Roth, Martyn Swinhoe, Paul A Bradley, Oliver Deppert, Michelle Espy, Katerina Falk, Nevzat Guler, Christopher Hamilton, Bjorn Manuel Hegelich, Daniela Henzlova, Kiril D Ianakiev, Metodi Iliev, Randall P Johnson, Annika Kleinschmidt, Adrian S Losko, Edward McCary, Michal Mocko, Ronald O Nelson, Rebecca Roycroft, Miguel A Santiago Cordoba, Victor A Schanz, Gabriel Schaumann, Derek W Schmidt, Adam Sefkow, Tsutomu Shimada, Terry N Taddeucci, Alexandra Tebartz, Sven C Vogel, Erik Vold, Glen A Wurden, Lin Yin
Laser-plasma interactions in the novel regime of relativistically induced transparency (RIT) have been harnessed to generate intense ion beams efficiently with average energies exceeding 10 MeV/nucleon (>100 MeV for protons) at "table-top" scales in experiments at the LANL Trident Laser. By further optimization of the laser and target, the RIT regime has been extended into a self-organized plasma mode. This mode yields an ion beam with much narrower energy spread while maintaining high ion energy and conversion efficiency...
May 2017: Physics of Plasmas
https://www.readbyqxmd.com/read/28651805/dental-implants-in-patients-with-osteoporosis-a-systematic-review-with-meta-analysis
#3
REVIEW
F C F L de Medeiros, G A H Kudo, B G Leme, P P Saraiva, F R Verri, H M Honório, E P Pellizzer, J F Santiago Junior
There is currently no consensus regarding the survival rate of osseointegrated implants in patients with osteoporosis. A systematic review with meta-analysis was performed to evaluate the survival rate of implants in such patients. The PubMed/MEDLINE, Web of Science, Cochrane Library, and SciELO databases were used to identify articles published up to September 2016. The systematic review was performed in accordance with PRISMA/PICO requirements and the risk of bias was assessed (Australian National Health and Medical Research Council scale)...
June 23, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28651474/epidemiology-and-changes-in-mortality-of-sepsis-after-the-implementation-of-surviving-sepsis-campaign-guidelines
#4
Rubén Herrán-Monge, Arturo Muriel-Bombín, Marta M García-García, Pedro A Merino-García, Miguel Martínez-Barrios, David Andaluz, Juan Carlos Ballesteros, Ana María Domínguez-Berrot, Susana Moradillo-Gonzalez, Santiago Macías, Braulio Álvarez-Martínez, M José Fernández-Calavia, Concepción Tarancón, Jesús Villar, Jesús Blanco
PURPOSE: To determine the epidemiology and outcome of severe sepsis and septic shock after 9 years of the implementation of the Surviving Sepsis Campaign (SSC) and to build a mortality prediction model. METHODS: This is a prospective, multicenter, observational study performed during a 5-month period in 2011 in a network of 11 intensive care units (ICUs). We compared our findings with those obtained in the same ICUs in a study conducted in 2002. RESULTS: The current cohort included 262 episodes of severe sepsis and/or septic shock, and the 2002 cohort included 324...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28651297/anomalous-origin-of-the-left-main-coronary-artery-arising-from-the-left-ventricular-outflow-tract-with-a-retro-aortic-collateral-vessel
#5
Asad Khan, Jason Audlin, Santiago Miro, Debanik Chaudhuri, Robert Dunton
No abstract text is available yet for this article.
June 26, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28650381/potential-for-immune-driven-viral-polymorphisms-to-compromise-antiretroviral-based-pre-exposure-prophylaxis-for-prevention-of-hiv-1-infection
#6
Hiroyuki Gatanaga, Zabrina L Brumme, Emily Adland, Gustavo Reyes-Terán, Santiago Avila-Rios, Carlos R Mejía-Villatoro, Tsunefusa Hayashida, Takayuki Chikata, Giang Van Tran, Kinh Van Nguyen, Rita I Meza, Elsa Y Palou, Humberto Valenzuela-Ponce, Juan M Pascale, Guillermo Porras-Cortés, Marvin Manzanero, Guinevere Q Lee, Jeffrey N Martin, Mary N Carrington, Mina John, Simon Mallal, Art F Y Poon, Philip Goulder, Masafumi Takiguchi, Shinichi Oka
OBJECTIVE: Long-acting rilpivirine is a candidate for pre-exposure prophylaxis (PrEP) for prevention of HIV-1 infection. However, rilpivirine resistance mutations at reverse transcriptase codon 138 (RT-E138X) occur naturally in a minority of HIV-1-infected persons; in particular those expressing Human Leukocyte Antigen (HLA)-B*18 where RT-E138X arises as an immune escape mutation. We investigate the global prevalence, B*18-linkage and replicative cost of RT-E138X and its regional implications for rilpivirine PrEP...
June 23, 2017: AIDS
https://www.readbyqxmd.com/read/28650245/letter-in-reply-prognostic-prediction-by-liver-tissue-proteomic-profiling-in-patients-with-colorectal-liver-metastases
#7
Adalgiza Reyes, Josep Marti, Santiago Marfa, Wladimiro Jimenez, Vedrana Reichenbach, Amalia Pelegrina, Constantino Fondevila, Juan Cg Valdecasas, Josep Fuster
In response to: S Sabour. Prognostic prediction by liver tissue proteomic profiling in patients with colorectal liver metastases; rule of thumb.
June 26, 2017: Future Oncology
https://www.readbyqxmd.com/read/28649617/a-multifactorial-study-on-nutritional-status-binge-eating-and-physical-activity-as-main-factors-directly-influencing-body-weight-in-parkinson-s-disease
#8
Andrea Bril, Santiago Perez-Lloret, Malco Rossi, Sofía Fariña, Pierre Morisset, Laura Sorrentino, Micaela Iglesias, Alex Medina Escobar, Patricio Millar Vernetti, Daniel Cerquetti, Marcelo Merello
Weight lossisa multifactorial disorder commonly affecting Parkinson's disease patients. The aim of this study was to investigate the relationship between body weight, nutritional status, physical activity, and Parkinson's disease-related factors. A total of 114 consecutive Parkinson's disease patients without dietary restrictions were evaluated prospectively with respect to: nutritional status (Mini Nutritional Assessment), physical activity level (Yale Physical Activity Survey), MDS-UPDRS score, olfactory function, depression, cognitive functionand impulse-control disorders, among other variables...
2017: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/28649439/mechanisms-of-action-of-sacubitril-valsartan-on-cardiac-remodeling-a-systems-biology-approach
#9
Oriol Iborra-Egea, Carolina Gálvez-Montón, Santiago Roura, Isaac Perea-Gil, Cristina Prat-Vidal, Carolina Soler-Botija, Antoni Bayes-Genis
Sacubitril/Valsartan, proved superiority over other conventional heart failure management treatments, but its mechanisms of action remains obscure. In this study, we sought to explore the mechanistic details for Sacubitril/Valsartan in heart failure and post-myocardial infarction remodeling, using an in silico, systems biology approach. Myocardial transcriptome obtained in response to myocardial infarction in swine was analyzed to address post-infarction ventricular remodeling. Swine transcriptome hits were mapped to their human equivalents using Reciprocal Best (blast) Hits, Gene Name Correspondence, and InParanoid database...
2017: NPJ Systems Biology and Applications
https://www.readbyqxmd.com/read/28649040/oxidative-potential-of-particulate-matter-2-5-as-predictive-indicator-of-cellular-stress
#10
Bélinda Crobeddu, Leticia Aragao-Santiago, Linh-Chi Bui, Sonja Boland, Armelle Baeza Squiban
Particulate air pollution being recognized to be responsible for short and long term health effects, regulations for particulate matter with an aerodynamic diameter less than 2.5 (PM2.5) are more and more restrictive. PM2.5 regulation is based on mass without taking into account PM2.5 composition that drives toxicity. Measurement of the oxidative potential (OP) of PM could be an additional PM indicator that would encompass the PM components involved in oxidative stress, the main mechanism of PM toxicity. We compared different methods to evaluate the intrinsic oxidative potential of PM2...
June 22, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28648658/ultrasound-entheseal-abnormalities-at-the-distal-interphalangeal-joints-and-clinical-nail-involvement-in-patients-with-psoriasis-and-psoriatic-arthritis-supporting-the-nail-enthesitis-theory
#11
Maria Laura Acosta-Felquer, Santiago Ruta, Javier Rosa, Josefina Marin, Leandro Ferreyra-Garrot, Maria Laura Galimberti, Ricardo Galimberti, Ricardo Garcia-Monaco, Enrique R Soriano
OBJECTIVE: It has been shown that nail involvement in psoriasis is associated with systemic enthesopathy. Our objective was to evaluate the association of nail involvement and enthesopathy at distal interphalangeal joint (DIP) level in psoriasis (PsO) and psoriatic arthritis (PsA) patients. METHODS: Consecutive patients (54 PsO and 56 PsA) seen at the outpatients clinic in this cross-sectional study were included. All patients underwent both clinical and ultrasound (US) assessment on the same day...
May 11, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28647902/ultrasonography-assessment-of-heel-entheses-in-patients-with-spondyloarthritis-a-comparative-study-with-magnetic-resonance-imaging-and-conventional-radiography
#12
Rodrigo Aguila Maldonado, Santiago Ruta, María Laura Valuntas, Mercedes García
The aim of the present study was to determine the agreement between ultrasonography (US), magnetic resonance imaging (MRI), and conventional radiography (CR) in the detection of findings indicative of enthesopathy in spondyloarthritis (SpA) patients. A cross-sectional study was performed in 40 SpA patients. Heel entheses (Achilles tendon and plantar fascia) were bilaterally examined by US, MRI, and CR. The three imaging modalities were carried out by three independent operators blinded to the other imaging modality data...
June 25, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28645708/identification-of-major-routes-of-hiv-transmission-throughout-mesoamerica
#13
Antoine Chaillon, Santiago Avila-Ríos, Joel O Wertheim, Ann Dennis, Claudia García-Morales, Daniela Tapia-Trejo, Carlos Mejía-Villatoro, Juan M Pascale, Guillermo Porras-Cortés, Carlos J Quant-Durán, Ivette Lorenzana, Rita I Meza, Elsa Y Palou, Marvin Manzanero, Rolando A Cedillos, Gustavo Reyes-Terán, Sanjay R Mehta
BACKGROUND: Migration and travel are major drivers of the spread of infectious diseases. Geographic proximity and a common language facilitate travel and migration in Mesoamerica, which in turn could affect the spread of HIV in the region. METHODS: 6092 HIV-1 subtype B partial pol sequences sampled from unique antiretroviral treatment-naïve individuals from Mexico (40.7%), Guatemala (24.4%), Honduras (19%), Panama (8.2%), Nicaragua (5.5%), Belize (1.4%), and El Salvador (0...
June 20, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28645634/hormonal-behavior-correlates-with-follicular-recruitment-at-mid-gestation-in-the-south-american-plains-vizcacha-lagostomus-maximus-rodentia-caviomorpha
#14
Nicolas Alejandro Fraunhoffer, Federico Jensen, Noelia Leopardo, Pablo Ignacio Felipe Inserra, Analía Meilerman Abuelafia, María Beatriz Espinosa, Santiago Elías Charif, Verónica Berta Dorfman, Alfredo Daniel Vitullo
In mammals, hormonal regulation during gestation is crucial for embryo implantation and pregnancy success. This regulation is controlled through the level of progesterone (P4) that blocks the activity of the hypothalamic-hypophyseal-gonadal (HHG) axis. Previous studies in the pregnant South American plains vizcacha, Lagostomus maximus, have shown that the HHG axis activates around mid-gestation, promoting pre-ovulatory follicle formation. However, the characterization of the hormonal dynamics throughout gestation and its ovarian correlation has not been studied in depth...
June 20, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28644182/incidence-and-management-of-recurrence-in-patients-with-crohn-s-disease-who-have-undergone-intestinal-resection-the-practicrohn-study
#15
Eugeni Domènech, Valle Garcia, Marisa Iborra, Ana Gutiérrez, Santiago García-López, María D Martín Arranz, Esther Garcia-Planella, Marta Calvo, Luisa Castro, Miguel Mínguez, Carlos Taxonera, Berta Juliá, Luis Cea-Calvo, Cristina Romero, Manuel Barreiro-de Acosta
BACKGROUND: More than 50% of patients with Crohn's disease require intestinal resection at least once. Postoperative recurrence (POR) is almost uniform if prophylactic treatment is not started early. Endoscopic monitoring is generally advised. We studied the incidence and management of recurrence in patients who had undergone intestinal resection. METHODS: Practicrohn was an observational retrospective study performed in 26 Spanish hospitals including patients aged ≥18 years who underwent Crohn's disease-related ileocolonic resection between January 2007 and December 2010...
June 20, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28643845/on-the-advancement-of-therapeutic-penality-therapeutic-authority-personality-science-and-the-therapeutic-community
#16
Ruari-Santiago McBride
In this article I examine the advancement of therapeutic penality in the UK, a penal philosophy that reimagines prison policy, practices and environments utilising psychological knowledge. Adopting a historical approach, I show how modern therapeutic penality is linked to the emergence of personality science in the nineteenth century and the development of the democratic therapeutic community (DTC) model in the twentieth century. I outline how at the turn of the twenty-first century a catalytic event generated a moral panic that led the British government to mobilise psychological knowledge and technologies in an attempt to manage dangerous people with severe personality disorder...
June 23, 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/28643828/adaptability-of-the-metal-iii-iv-1-2-3-trioxobenzene-rod-secondary-building-unit-for-the-production-of-chemically-stable-and-catalytically-active-mofs
#17
Georges Mouchaham, Brian Abeykoon, Mónica Giménez-Marqués, Sergio Navalon, Andrea Santiago-Portillo, Maame Affram, Nathalie Guillou, Charlotte Martineau, Hermenegildo Garcia, Alexandra Fateeva, Thomas Devic
The use of a 5,10,15,20-tetrakis(3,4,5-trihydroxyphenyl)porphyrin has yielded a new MOF based on M-1,2,3-trioxobenzene chains that can be made of M = Zr(iv) or RE(iii) (RE = rare earth), showing a very high and limited chemical stability, respectively. The robust metallated Zr-analogue, Co-MIL-173(Zr), has proven to be a heme-like heterogeneous catalyst suitable for aerobic oxidation of hydrocarbons.
June 23, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28643066/solving-the-surgeon-ergonomic-crisis-with-surgical-exosuit
#18
Shanglei Liu, Daniel Hemming, Ran B Luo, Jessica Reynolds, Jonathan C Delong, Bryan J Sandler, Garth R Jacobsen, Santiago Horgan
INTRODUCTION: The widespread adoption of laparoscopic surgery has put new physical demands on the surgeon leading to increased musculoskeletal disorders and injuries. Shoulder, back, and neck pains are among the most common complaints experienced by laparoscopic surgeons. Here, we evaluate the feasibility and efficacy of a non-intrusive progressive arm support exosuit worn by surgeons under the sterile gown to reduce pain and fatigue during surgery. METHODS AND PROCEDURES: This is a prospective randomized crossover study approved by the Internal Review Board (IRB)...
June 22, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28643043/-18-f-florbetaben-pet-beta-amyloid-binding-expressed-in-centiloids
#19
Christopher C Rowe, Vincent Doré, Gareth Jones, David Baxendale, Rachel S Mulligan, Santiago Bullich, Andrew W Stephens, Susan De Santi, Colin L Masters, Ludger Dinkelborg, Victor L Villemagne
PURPOSE: The Centiloid (CL) method enables quantitative values from Aβ-amyloid (Aβ) imaging to be expressed in a universal unit providing pathological, diagnostic and prognostic thresholds in clinical practice and research and allowing integration of multiple tracers and methods. The method was developed for (11)C-PiB scans with zero CL set as the average in young normal subjects and 100 CL the average in subjects with mild Alzheimer's disease (AD). The method allows derivation of equations to convert the uptake value of any tracer into the same standard CL units but first requires head-to-head comparison with (11)C-PiB results...
June 22, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28642952/solventless-mechanochemical-preparation-of-novel-magnetic-bioconjugates
#20
Daily Rodriguez-Padrón, Alain R Puente-Santiago, Alina M Balu, Antonio A Romero, Rafael Luque
A solventless mechanochemical approach was employed to obtain a bioconjugate (BSA-DA-Fe2O3) based on bovine serum albumin (BSA) and dopamine (DA) coated iron oxide magnetic nanoparticles. UV-vis measurements of the obtained material showed a distinctive peak at 280 nm which, together with the presence of N on the surface of the nanomaterial (a band at 400 eV in the XPS spectrum) and zeta potential measurements, confirmed the successful immobilization of the protein. Additionally, the presence of two bands at 1652 and 1545 cm(-1) in the FT-IR spectra of both BSA and BSA-DA-Fe2O3 and steady-state fluorescence analysis validated that the protein preserved its native-like structure after the mechanochemical milling process...
June 23, 2017: Chemical Communications: Chem Comm
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