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https://www.readbyqxmd.com/read/29231772/changes-in-the-prevalence-and-severity-of-recurrent-wheezing-in-infants-the-results-of-two-surveys-administered-7%C3%A2-years-apart
#1
Javier Mallol, Dirceu Solé, Viviana Aguirre, Herberto Chong, Nelson Rosario, Luis García-Marcos, The Eisl Study Group
OBJECTIVE: To identify changes in the prevalence and severity of recurrent wheezing (RW) in infants using data obtained from two surveys administered seven years apart. METHODS: A cross-sectional, international, population-based study in infants aged 12-15 months was conducted. Data were obtained from two surveys (S1 and S2, in 2005 and 2012, respectively) using the same methodology in three large Latin American cities: Curitiba (Brazil), São Paulo (Brazil), and Santiago (Chile)...
December 12, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29231187/-emergency-medical-technician-profile-in-spain
#2
Santiago Martínez-Isasi, María José Rodríguez-Lorenzo, David Vázquez-Santamariña, Javier Abella-Lorenzo, Diana Josefa Castro Dios, Daniel Fernández García
OBJECTIVE: The emergency medical technician plays a fundamental role and is the most important figure quantitatively in pre-hospital emergencies. The aim was to asses the socio-demographic, work-related, health characteristics and technical skills of an Emergency Medical Technician in Spain. METHODS: Cross-sectional descriptive study. An ad hoc questionnaire was managed using Google Docs® that was delivered between April-June 2014 via email and social networks...
December 11, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/29229578/left-lateral-endosurgical-extraperitoneal-total-hysterectomy-with-para-aortic-and-pelvic-lymphadenectomy-a-novel-approach-for-the-obese-patient-with-endometrial-cancer
#3
Gwenael Ferron, Javier De Santiago, Denis Querleu, Alejandra Martinez, Martina Aida Angeles, Berenice Boulet, Frederic Guyon, Ignacio Zapardiel
STUDY OBJECTIVE: To describe the left lateral extraperitoneal approach to perform complete para-aortic and pelvic lymphadenectomy and transverse total hysterectomy from left to right as a novel approach to treat obese patients with endometrial cancer. Laparoscopic management of obese patients represents a challenge for the gynecological surgeon. The extraperitoneal approach is technically easier in the obese patient as it naturally creates a bowel-free operative field. DESIGN: A prospective pilot bicentric and descriptive study (Canadian Task Force III) evaluating the feasibility and reproducibility of the transverse total hysterectomy and complete lymphadenectomy through left endoscopic extraperitoneal approach in obese patients with endometrial cancer...
December 8, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29229373/paper-based-detection-of-hiv-1-drug-resistance-using-isothermal-amplification-and-an-oligonucleotide-ligation-assay
#4
Mary E Natoli, Brittany A Rohrman, Carolina de Santiago, Gert U van Zyl, Rebecca R Richards-Kortum
Regular HIV-1 viral load monitoring is the standard of care to assess antiretroviral therapy effectiveness in resource-rich settings. Persistently elevated viral loads indicate virologic failure (VF), which warrants HIV drug resistance testing (HIVDRT) to allow individualized regimen switches. However, in settings lacking access to HIVDRT, clinical decisions are often made based on symptoms, leading to unnecessary therapy switches and increased costs of care. This work presents a proof-of-concept assay to detect M184V, the most common drug resistance mutation after first-line antiretroviral therapy failure, in a paper format...
December 8, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/29229262/heart-transplantation-in-patients-%C3%A2-60-years-importance-of-relative-pulmonary-hypertension-and-right-ventricular-failure-on-midterm-survival
#5
Juan C Bianco, Santiago Mc Loughlin, André Y Denault, Ricardo G Marenchino, Juan I Rojas, Francisco C Bonofiglio
OBJECTIVES: To determine the impact of recipient age and perioperative risk factors on midterm survival after orthotopic heart transplantation (OHT). The authors hypothesized that perioperative variables are more important as predictors of mortality than is a recipient's age. DESIGN: Retrospective study. SETTING: Tertiary care university hospital. PARTICIPANTS: The study comprised 126 consecutive adults who underwent OHT...
September 18, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29229120/susceptibility-of-eptfe-vascular-grafts-and-bioengineered-human-acellular-vessels-to-infection
#6
Robert D Kirkton, Heather L Prichard, Maribel Santiago-Maysonet, Laura E Niklason, Jeffrey H Lawson, Shannon L M Dahl
BACKGROUND: Synthetic expanded polytetrafluorethylene (ePTFE) grafts are routinely used for vascular repair and reconstruction but prone to sustained bacterial infections. Investigational bioengineered human acellular vessels (HAVs) have shown clinical success and may confer lower susceptibility to infection. Here we directly compared the susceptibility of ePTFE grafts and HAV to bacterial contamination in a preclinical model of infection. MATERIALS AND METHODS: Sections (1 cm2) of ePTFE (n = 42) or HAV (n = 42) were inserted within bilateral subcutaneous pockets on the dorsum of rats and inoculated with Staphylococcus aureus (107 CFU/0...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29228998/capturing-health-and-eating-status-through-a-nutritional-perception-screening-questionnaire-npsq9-in-a-randomised-internet-based-personalised-nutrition-intervention-the-food4me-study
#7
Rodrigo San-Cristobal, Santiago Navas-Carretero, Carlos Celis-Morales, Katherine M Livingstone, Barbara Stewart-Knox, Audrey Rankin, Anna L Macready, Rosalind Fallaize, Clare B O'Donovan, Hannah Forster, Clara Woolhead, Marianne C Walsh, Christina P Lambrinou, George Moschonis, Yannis Manios, Miroslaw Jarosz, Hannelore Daniel, Eileen R Gibney, Lorraine Brennan, Thomas E Gundersen, Christian A Drevon, Mike Gibney, Cyril F M Marsaux, Wim H M Saris, Julie A Lovegrove, Lynn J Frewer, John C Mathers, J Alfredo Martinez
BACKGROUND: National guidelines emphasize healthy eating to promote wellbeing and prevention of non-communicable diseases. The perceived healthiness of food is determined by many factors affecting food intake. A positive perception of healthy eating has been shown to be associated with greater diet quality. Internet-based methodologies allow contact with large populations. Our present study aims to design and evaluate a short nutritional perception questionnaire, to be used as a screening tool for assessing nutritional status, and to predict an optimal level of personalisation in nutritional advice delivered via the Internet...
December 11, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29227860/respiratory-syncytial-virus-in-brazilian-infants-ten-years-two-cohorts
#8
Elinara Wollmeister, Alfonso Eduardo Alvarez, Juliana Cristina Santiago Bastos, Fernando Augusto Lima Marson, José Dirceu Ribeiro, Emílio Carlos Elias Baracat, Clarice Weis Arns, Adriana Gut Lopes Riccetto
BACKGROUND: Each year, a considerable amount of children will experience at least one episode of acute viral bronchiolitis (AVB) during their first year of life. About 10% of them will be hospitalized, with significant physical and economic burdens. OBJECTIVES: To compare two cohorts of infants with AVB, from same region, in a ten-year interval, regarding epidemiologic factors and viral etiology. STUDY DESIGN: Cohorts: 142 (2004) and 172 (2014) infants at ages zero to 12 months; clinical diagnosis of AVB; medical care in hospital and genetic screening of nasopharyngeal secretion for respiratory viruses...
December 6, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29226851/main-problems-and-suggested-solutions-for-improving-radiation-protection-in-medicine-in-ibero-american-countries-summary-of-an-international-conference-held-in-madrid-2016
#9
Eliseo Vano, Pablo Jimenez, Raul Ramirez, Javier Zarzuela, Ana Maria Larcher, Eduardo Gallego, Santiago Gonzalez, Maria Del Rosario Perez
During the International Conference on Radiation Protection in Medicine held in Bonn in 2012, several areas for improvement were identified, including specific actions related with justification, optimization, role of manufacturers, radiation protection education and training, strategic research, data collection on medical and occupational exposures, prevention of incidents and accidents, radiation safety culture, risk-benefit dialogue and implementation of the radiation safety standards. The outcomes of the Bonn Conference were summarized in the so-called 'Bonn Call for Action', identifying 10 priority actions to enhance RP in medicine...
December 11, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29226823/multisensory-influence-on-eating-behavior-hedonic-consumption
#10
María Hernández Ruiz de Eguilaz, Blanca Martínez de Morentin Aldabe, Eva Almiron-Roig, Salomé Pérez-Diez, Rodrigo San Cristóbal Blanco, Santiago Navas-Carretero, J Alfredo Martínez
Research in obesity has traditionally focused on prevention strategies and treatments aimed at changing lifestyle habits. However, recent research suggests that eating behavior is a habit regulated not only by homeostatic mechanisms, but also by the hedonic pathway that controls appetite and satiety processes. Cognitive, emotional, social, economic, and cultural factors, as well as organoleptic properties of food, are basic aspects to consider in order to understand eating behavior and its impact on health...
December 6, 2017: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29225340/genetic-and-experimental-evidence-for-the-involvement-of-the-cd6-lymphocyte-receptor-in-psoriasis
#11
Marta Consuegra-Fernández, Marc Julià, Mario Martínez-Florensa, Fernando Aranda, Cristina Català, Noelia Armiger-Borràs, María-Teresa Arias, Francisca Santiago, Antonio Guilabert, Anna Esteve, Carlos Muñoz, Carlos Ferrándiz, José-Manuel Carrascosa, Edurne Pedrosa, Jorge Romaní, Mercè Alsina, José-Manuel Mascaró-Galy, Francisco Lozano
Psoriasis is a chronic inflammatory skin disease with a strong genetic background and is triggered by environmental factors. Available evidence supports CD6, a lymphocyte surface receptor mostly expressed by T cells, as a putative target in autoimmunity. Accordingly, a humanized anti-CD6 antibody has been assayed for the treatment of certain autoimmune disorders, including psoriasis. Here, we present novel evidence in mice and humans for a direct involvement of CD6 in psoriasis pathophysiology. First, an attenuated form of imiquimod-induced psoriasis-like skin inflammation was demonstrated in CD6-deficient mice, as deduced from lower epidermal thickness and local reduced production of pro-inflammatory cytokines, namely, interleukin-17A...
December 11, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29224222/chronic-pain-in-the-school-setting-the-teachers-point-of-view
#12
Ester Solé, Elena Castarlenas, Elisabet Sánchez-Rodríguez, Santiago Galán, Rocío de la Vega, Mark P Jensen, Jordi Miró
BACKGROUND: The aims of this study were to (1) examine the reactions of teachers and student teachers to children experiencing pain, (2) identify the most common challenges and potential resources that are associated to dealing with them, and (3) examine whether their responses differed as a function of their experience or sex. METHODS: Forty teachers and 318 student teachers completed a survey which included descriptive information, a questionnaire that assesses different responses of participants to children who experience pain, and provides a list of problems and resources that participants might encounter and implement, respectively, when dealing with these children...
January 2018: Journal of School Health
https://www.readbyqxmd.com/read/29223477/immuno-oncology-from-the-perspective-of-somatic-evolution
#13
REVIEW
Santiago González, Nadezda Volkova, Philip Beer, Moritz Gerstung
The past years have witnessed significant success for cancer immunotherapies that activate a patient's immune system against their cancer cells. At the same time our understanding of the genetic changes driving tumor evolution have progressed dramatically. The study of cancer genomes has shown that tumors are best understood as cell populations governed by the rules of evolution, leading to the emergence and spread of cell lineages with pathogenic mutations. Moreover, somatic evolution can explain the acquisition of mutations conferring drug resistance in the ever-lasting battle for reaching even fitter cell states...
December 6, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29223472/-excess-weight-and-abdominal-obesity-in-galician-children-and-adolescents
#14
Mónica Pérez-Ríos, María Isolina Santiago-Pérez, Rosaura Leis, Ana Martínez, Alberto Malvar, Xurxo Hervada, Jorge Suanzes
INTRODUCTION AND OBJECTIVES: The excess of weight, mainly obesity, during childhood and adolescence increases morbimortality risk in adulthood. The aim of this article is to estimate both the overall prevalence, as well as according to age and gender, of underweight, overweight, obesity and abdominal obesity among schoolchildren aged between 6-15-years-old in the school year 2013-2014. MATERIAL AND METHODS: Data were taken from a cross-sectional community-based study carried out on a representative sample, by gender and age, of the Galician population aged between 6 and 15 years-old...
December 6, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29221955/comparison-of-external-and-internal-implant-abutment-connections-for-implant-supported-prostheses-a-systematic-review-and-meta-analysis
#15
REVIEW
Cleidiel Aparecido Araujo Lemos, Fellippo Ramos Verri, Estevam Augusto Bonfante, Joel Ferreira Santiago, Eduardo Piza Pellizzer
OBJECTIVE: The systematic review and meta-analysis aimed to answer the PICO question: "Do patients that received external connection implants show similar marginal bone loss, implant survival and complication rates as internal connection implants?". DATA: Meta-analyses of marginal bone loss, survival rates of implants and complications rates were performed for the included studies. Study eligibility criteria included (1) randomized controlled trials (RCTs) and/or prospective, (2) studies with at least 10 patients, (3) direct comparison between connection types and (4) publications in English language...
December 5, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29221885/-design-of-a-questionnaire-on-the-knowledge-and-attitudes-of-the-population-of-madrid-spain-facing-the-end-of-life
#16
Belén Ortiz-Gonçalves, Andrés Santiago-Sáez, Elena Albarrán Juan, Elena Labajo González, Bernardo Perea-Pérez
OBJECTIVE: To create and validate a questionnaire about knowledge and attitudes of the general population in Madrid (Spain) about life's end stage. METHOD: A descriptive study designed as a structured self-administered questionnaire, validated by seven Madrid Health Service professional experts and assessed through a pilot study. RESULTS: The questionnaire consisted of 42 questions, divided into six modules: 1) decisions and psychological-physical care at life's end; 2) palliative care; 3) euthanasia and assisted suicide; 4) advance directives document; 5) spiritual factors; and 6) socio-demographic data...
December 5, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/29221827/prevalence-of-copd-in-6-urban-clusters-in-argentina-the-epoc-ar-study
#17
Andrés L Echazarreta, Sergio J Arias, Ricardo Del Olmo, Eduardo R Giugno, Federico D Colodenco, Santiago C Arce, Juan C Bossio, Gustavo Armando, Joan B Soriano
INTRODUCTION: The prevalence of chronic obstructive pulmonary disease (COPD) has not been studied in Argentina. OBJECTIVES: To determine the prevalence and relevant clinical characteristics of COPD in a representative sample. MATERIAL AND METHODS: We performed a cross-sectional study in a population of adults aged ≥ 40 years randomly selected by cluster sampling in 6 urban locations. Subjects answered a structured survey and performed pre- and post-bronchodilator spirometry (PBD)...
December 5, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29220790/2-alkoxycarbonyl-3-arylamino-5-substituted-thiophenes-as-a-novel-class-of-antimicrotubule-agents-design-synthesis-cell-growth-and-tubulin-polymerization-inhibition
#18
Romeo Romagnoli, Maria Kimatrai Salvador, Santiago Schiaffino Ortega, Pier Giovanni Baraldi, Paola Oliva, Stefania Baraldi, Luisa Carlota Lopez-Cara, Andrea Brancale, Salvatore Ferla, Ernest Hamel, Jan Balzarini, Sandra Liekens, Elena Mattiuzzo, Giuseppe Basso, Giampietro Viola
Microtubules are recognized as crucial components of the mitotic spindle during cell division, and, for this reason, the microtubule system is an attractive target for the development of anticancer agents. Continuing our search strategy for novel tubulin targeting-compounds, a new series of 2-alkoxycarbonyl-3-(3',4',5'-trimethoxyanilino)-5-aryl/heteroarylthiophene derivatives was designed, synthesized and demonstrated to act as tubulin polymerization inhibitors at the colchicine site. A structure-activity relationship study on the phenyl at the 5-position of the thiophene ring was performed by introducing a variety of substituents containing electron-releasing and electron-withdrawing groups, with the 2-alkoxycarbonyl-3-(3',4',5'-trimethoxyanilino)thiophene scaffold being the minimum structural requirement for activity...
December 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29220568/aniline-based-inhibitors-of-influenza-h1n1-virus-acting-on-hemagglutinin-mediated-fusion
#19
Rosana Leiva, Marta Barniol-Xicota, Sandra Codony, Tiziana Ginex, Evelien Vanderlinden, Marta Montes, Michael Caffrey, F Javier Luque, Lieve Naesens, Santiago Vazquez
Two series of easily accessible anilines were identified as inhibitors of influenza A virus subtype H1N1, and extensive chemical synthesis and analysis of the structure-activity relationship were performed. The compounds were shown to interfere with low pH-induced membrane fusion mediated by the H1 and H5 (group 1) hemagglutinin (HA) subtypes. A combination of virus resistance, HA interaction and molecular dynamics simulation studies elucidated the binding site of these aniline-based influenza fusion inhibitors, which significantly overlaps with the pocket occupied by some H3 HA-specific inhibitors, indicating the high relevance of this cavity for drug design...
December 8, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29220068/assessing-the-decrease-in-the-surgical-population-of-the-university-of-puerto-rico-affiliated-hospitals
#20
Norma I Cruz, Elvis Santiago, César Luque
OBJECTIVE: To evaluate the magnitude of the decrease in the surgical population of the University of Puerto Rico (UPR)-affiliated hospitals. METHODS: We examined all the surgical cases that were entered into the Surgical Database from January 1, 2013, through December 31, 2015. This database collects patient and procedural information from the surgical services of the UPR-affiliated hospitals. Thus, the number of surgical patients for the 3-year study period was determined and their characteristics recorded...
December 2017: Puerto Rico Health Sciences Journal
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