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Exercise in Parkinson's disease

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https://www.readbyqxmd.com/read/29207899/effect-of-a-mat-pilates-program-with-theraband%C3%A2-on-dynamic-balance-in-patients-with-parkinson-s-disease-feasibility-study-and-randomized-controlled-trial
#1
Irimia Mollinedo, Jose Maria Cancela, María Helena Vila Suarez
OBJECTIVES: The aim of this study is to assess the effect of a physical exercise program based on Mat Pilates with TheraBand® on the dynamic balance of a sample population diagnosed with Parkinson's Disease (PD). METHOD: After random selection, 26 participants were allocated to a Mat Pilates group or a control group where they performed calisthenics exercises. Both interventions lasted 12 weeks and involved two weekly sessions of 60 minutes. Assessments took place at baseline, 12 weeks after the intervention started and 4 weeks after the intervention was completed using the Body Mass Index (BMI), the Timed Up and Go (TUG) test with Wiva® sensors, the 30 Second Chair Stand test and the Five Times Sit to Stand test...
December 5, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/29206708/use-of-a-telehealth-system-to-enhance-a-home-exercise-program-for-a-person-with-parkinson-disease-a-case-report
#2
Charlotte A Chatto, Paul T York, Catherine P Slade, Scott M Hasson
BACKGROUND AND PURPOSE: This case addresses feasibility of a home-based telehealth system to enhance home exercise program (HEP) adherence for a patient with Parkinson disease (PD). We describe START-System for Technology-Augmented Rehabilitation and Training-and discuss outcomes after integrating START into the HEP component of an established therapy protocol, Lee Silverman Voice Technique BIG (LSVT BIG). CASE DESCRIPTION: The participant was a 67-year-old woman with PD at Hoehn and Yahr Stage II...
December 1, 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/29204298/treadmill-exercise-improves-motor-dysfunction-and-hyperactivity-of-the-corticostriatal-glutamatergic-pathway-in-rats-with-6-ohda-induced-parkinson-s-disease
#3
Wei Chen, Decai Qiao, Xiaoli Liu, Kaixuan Shi
Hyperactivity in the corticostriatal glutamatergic pathway (CGP) induces basal ganglia dysfunction, contributing to parkinsonian syndrome (PS). Physical exercise can improve PS. However, the effect of exercise on the CGP, and whether this pathway is involved in the improvement of PS, remains unclear. Parkinson's disease (PD) was induced in rats by 6-hydroxydopamine injection into the right medial forebrain bundle. Motor function was assessed using the cylinder test. Striatal neuron (SN) spontaneous and evoked firing activity was recorded, and the expression levels of Cav1...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/29198450/effects-of-exercise-on-non-motor-symptoms-in-parkinson-s-disease
#4
Amy W Amara, Adeel A Memon
Patients with Parkinson's disease experience disabling non-motor symptoms, including autonomic dysfunction, cognitive decline, and sleep disorders. Pharmacologic treatments for these symptoms are often ineffective or have intolerable side effects. Therefore, non-pharmacologic interventions are an attractive alternative. Exercise in particular has the potential to alleviate the progressive impairment related to these non-motor symptoms. In this commentary, we explore available research that addresses the impact of exercise and physical activity on autonomic dysfunction, cognitive impairment, and sleep disorders in Parkinson's disease and suggest areas in need of further study...
November 30, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29163185/orthostatic-intolerance-in-older-persons-etiology-and-countermeasures
#5
REVIEW
Nandu Goswami, Andrew P Blaber, Helmut Hinghofer-Szalkay, Jean-Pierre Montani
Orthostatic challenge produced by upright posture may lead to syncope if the cardiovascular system is unable to maintain adequate brain perfusion. This review outlines orthostatic intolerance related to the aging process, long-term bedrest confinement, drugs, and disease. Aging-associated illness or injury due to falls often leads to hospitalization. Older patients spend up to 83% of hospital admission lying in bed and thus the consequences of bedrest confinement such as physiological deconditioning, functional decline, and orthostatic intolerance represent a central challenge in the care of the vulnerable older population...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29163139/exercise-induced-neuroprotection-of-the-nigrostriatal-dopamine-system-in-parkinson-s-disease
#6
REVIEW
Lijuan Hou, Wei Chen, Xiaoli Liu, Decai Qiao, Fu-Ming Zhou
Epidemiological studies indicate that physical activity and exercise may reduce the risk of developing Parkinson's disease (PD), and clinical observations suggest that physical exercise can reduce the motor symptoms in PD patients. In experimental animals, a profound observation is that exercise of appropriate timing, duration, and intensity can reduce toxin-induced lesion of the nigrostriatal dopamine (DA) system in animal PD models, although negative results have also been reported, potentially due to inappropriate timing and intensity of the exercise regimen...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29158667/different-protocols-for-analyzing-behavior-and-adaptability-in-obstacle-crossing-in-parkinson-s-disease
#7
REVIEW
Nafiseh Mollaei, Estela Bicho, Nuno Sousa, Miguel Fernandes Gago
Imbalance and tripping over obstacles as a result of altered gait in older adults, especially in patients with Parkinson's disease (PD), are one of the most common causes of falls. During obstacle crossing, patients with PD modify their behavior in order to decrease the mechanical demands and enhance dynamic stability. Various descriptions of dynamic traits of gait that have been collected over longer periods, probably better synthesize the underlying structure and pattern of fluctuations in gait and can be more sensitive markers of aging or early neurological dysfunction and increased risk of falls...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29103050/motivators-and-barriers-to-exercise-in-parkinson-s-disease
#8
Mitra Afshari, Amy Yang, Danny Bega
BACKGROUND: Despite evidence for the benefits of exercise in Parkinson's disease (PD), many patients remain sedentary for undefined reasons. OBJECTIVE: To compare exercise habits, perceptions about exercise, and barriers to exercise in 'low' (<3 h/week) and 'high' (≥3 h/week) exercisers with PD. METHODS: A 48-item survey was administered to PD patients at an outpatient academic center. Chi-squared tests were used to compare the percentage differences between low- and high-exercisers with two-sided tests and a significant level of 0...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29096672/the-effects-of-yoga-versus-stretching-and-resistance-training-exercises-on-psychological-distress-for-people-with-mild-to-moderate-parkinson-s-disease-study-prxotocol-for-a-randomized-controlled-trial
#9
JoJo Yan Yan Kwok, Jackie Cheuk Yin Kwan, Man Auyeung, Vincent Chung Tong Mok, Helen Yue Lai Chan
BACKGROUND: Psychological distress is prevalent among people with Parkinson's disease (PD) and aggravates their motor symptoms, thereby leading to increased disability, high healthcare costs, and poor health-related quality of life (HRQoL). The under-recognition and adverse effects of the pharmacological management of anxiety and depression among the PD population are considerable. Thus, adopting a Complementary and Alternative Management (CAM) approach to address this problem is important...
November 2, 2017: Trials
https://www.readbyqxmd.com/read/29095706/trunk-exercises-improve-gait-symmetry-in-parkinson-disease-a-blind-phase-ii-randomised-controlled-trial
#10
Ryan P Hubble, Geraldine Naughton, Peter A Silburn, Michael H Cole
OBJECTIVE: Deficits in step-to-step symmetry and trunk muscle activations have been linked to falls in Parkinson's disease (PD). Given such symptoms are poorly managed with anti-parkinsonian medications, alternate therapies are needed. This blind phase II randomised-controlled trial sought to establish whether exercise can improve step-to-step symmetry in PD. DESIGN: Twenty-four PD patients with a falls history completed baseline assessments of symptom severity, balance confidence, mobility and quality of life...
November 1, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29060349/template-dtw-based-on-inertial-signals-preliminary-results-for-step-characterization
#11
Juan Mantilla, Laurent Oudre, Remi Barrois, Alienor Vienne, Damien Ricard
In this paper, we present a method for the creation of a library of inertial signals based on Dynamic Time Warping (DTW) for step characterization, with preliminary results in control subjects and patients with neurological diseases. Subjects performed a protocol including a 10 m straight walking, then turn back and walking for additional 10 m. The library is constructed with inertial signals (acceleration and angular velocities recorded in three directions) aligned with the DTW. Templates in the library are obtained for a specific cohort and for the different walking phases of the protocol...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29055387/the-colon-revisited-or-the-key-to-wellness-health-and-disease
#12
C A Gonzalez-Correa, E Mulett-Vásquez, D A Miranda, C H Gonzalez-Correa, P A Gómez-Buitrago
The hypothesis being advanced in this paper is that there is a new medical paradigm emerging from the biomedical research carried out in this century, mainly due to the explosion of the so called "omics" and associated techniques. The main idea is that there is a common pathway from wellbeing and health to chronic disease ("chronopathy") and even to death, which comprises following steps: 1) unhealthy diet, sedentary life style and permanent exposition to xenobiotics and all kinds of noxious stimuli;→2) intestinal dysbiosis;→3) alteration of the intestinal mucus layer (especially that of the colon);→4) disruption of the endothelial tight junctions;→5) metabolic endotoxemia+bacterial translocation;→6) inflammation;→7) exacerbation of the enteric nervous system (ENS) and consequent maladaptation and malfunctioning of the colon;→8) epigenetic manifestations;→9) "chronopathy" and premature death...
October 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29053448/the-effects-of-coding-schemes-on-vibrotactile-biofeedback-for-dynamic-balance-training-in-parkinson-s-disease-and-healthy-elderly-individuals
#13
Beom-Chan Lee, Alberto Fung, Timothy A Thrasher
A coding scheme for earlier versions of vibrotactile biofeedback systems for balance-related applications was primarily binary in nature, either off or on at a given threshold (range of postural tilt), making it unable to convey information about error magnitude. The purpose of this study was to explore the effects of two coding schemes (binary vs. continuous) for vibrotactile biofeedback during dynamic weight-shifting exercises that are common physical therapists' recommended balance exercises used in clinical settings...
October 16, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29042162/pronation-and-supination-analysis-based-on-biomechanical-signals-from-parkinson-s-disease-patients
#14
Alejandro Garza-Rodríguez, Luis Pastor Sánchez-Fernández, Luis Alejandro Sánchez-Pérez, Christopher Ornelas-Vences, Mariane Ehrenberg-Inzunza
In this work, a fuzzy inference model to evaluate hands pronation/supination exercises during the MDS-UPDRS motor examination is proposed to analyze different extracted features from the bio-mechanical signals acquired from patients with Parkinson's disease (PD) in different stages of severity. Expert examiners perform visual assessments to evaluate several aspects of the disease. Some previous work on this subject does not contemplate the MDS-UPDRS guidelines. The method proposed in this work quantifies the biomechanical features examiners evaluate...
October 14, 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/29027544/long-term-effects-of-exercise-and-physical-therapy-in-people-with-parkinson-disease
#15
REVIEW
Margaret K Mak, Irene S Wong-Yu, Xia Shen, Chloe L Chung
Parkinson disease (PD) is a progressive, neurodegenerative movement disorder with symptoms reflecting various impairments and functional limitations, such as postural instability, gait disturbance, immobility and falls. In addition to pharmacological and surgical management of PD, exercise and physical therapy interventions are also being actively researched. This Review provides an overview of the effects of PD on physical activity - including muscle weakness, reduced aerobic capacity, gait impairment, balance disorders and falls...
November 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29019056/physical-exercise-modulates-l-dopa-regulated-molecular-pathways-in-the-mptp-mouse-model-of-parkinson-s-disease
#16
Cornelius J H M Klemann, Helena Xicoy, Geert Poelmans, Bas R Bloem, Gerard J M Martens, Jasper E Visser
Parkinson's disease (PD) is characterized by the degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc), resulting in motor and non-motor dysfunction. Physical exercise improves these symptoms in PD patients. To explore the molecular mechanisms underlying the beneficial effects of physical exercise, we exposed 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine (MPTP)-treated mice to a four-week physical exercise regimen, and subsequently explored their motor performance and the transcriptome of multiple PD-linked brain areas...
October 10, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28988910/neuroprotection-and-neurorestoration-as-experimental-therapeutics-for-parkinson-s-disease
#17
REVIEW
Veronica Francardo, Yvonne Schmitz, David Sulzer, M Angela Cenci
Disease-modifying treatments remain an unmet medical need in Parkinson's disease (PD). Such treatments can be operationally defined as interventions that slow down the clinical evolution to advanced disease milestones. A treatment may achieve this outcome by either inhibiting primary neurodegenerative events ("neuroprotection") or boosting compensatory and regenerative mechanisms in the brain ("neurorestoration"). Here we review experimental paradigms that are currently used to assess the neuroprotective and neurorestorative potential of candidate treatments in animal models of PD...
October 5, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28986095/modulation-of-mitochondrial-dynamics-by-treadmill-training-to-improve-gait-and-mitochondrial-deficiency-in-a-rat-model-of-parkinson-s-disease
#18
Chieh-Sen Chuang, Jui-Chih Chang, Fu-Chou Cheng, Ko-Hung Liu, Hong-Lin Su, Chin-San Liu
PURPOSE: Parkinson's disease (PD) is a progressive degenerative central nervous system disorder that particularly impairs motor function. As PD advances, gait disorders become more pronounced and are often difficult to treat with current pharmacological therapies. Physical activity improves both mobility in and the daily living activities of patients with PD. Mitochondrial alterations and oxidative stress contribute to PD progression. Therefore, the association between mitochondria and exercise in PD and the implicated regulation of mitochondrial proteins was explored in this study...
October 3, 2017: Life Sciences
https://www.readbyqxmd.com/read/28981227/-treatment-of-parkinson-s-disease
#19
S Dethy
Parkinson's disease in a neurodegenerative disorder that affects as many as 1-2 % of persons aged 60 years and older. Parkinson's disease occurs infrequently under 40 years of age, with major genetic implication. Alpha-synuclein plays significant pathogenic role in Parkinson's disease. Therapeutic advances based on a synucleinrelated mechanism are now developed : immunotherapy against alpha-synuclein for example. The diagnosis of Parkinson's disease remains mostly clinical. DatScan® may be helpful to distinguish parkinsonian syndrome and essential tremor...
2017: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/28980476/lee-silverman-voice-treatment-lsvt-big-to-improve-motor-function-in-people-with-parkinson-s-disease-a-systematic-review-and-meta-analysis
#20
Michelle N McDonnell, Briony Rischbieth, Tenille T Schammer, Chantel Seaforth, Alex J Shaw, Anna C Phillips
OBJECTIVE: The technique called Lee Silverman Voice Treatment (LSVT)-LOUD has previously been used to improve voice quality in people with Parkinson's disease. The objective of this study was to assess the effectiveness of an alternate intervention, LSVT-BIG (signifying big movements), to improve functional mobility. DESIGN: Systematic review with meta-analysis of randomized trials. DATA SOURCES: Medline, Embase, CINAHL, AgeLine, Scopus and Cochrane Library were searched from inception to September 2017 using multiple search terms related to Parkinson's disease and LSVT-BIG...
October 1, 2017: Clinical Rehabilitation
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