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Rachel A Queen, Jannetta S Steyn, Phillip Lord, Joanna L Elson
Mitochondrial DNA (mtDNA) mutations are well recognized as an important cause of inherited disease. Diseases caused by mtDNA mutations exhibit a high degree of clinical heterogeneity with a complex genotype-phenotype relationship, with many such mutations exhibiting incomplete penetrance. There is evidence that the spectrum of mutations causing mitochondrial disease might differ between different mitochondrial lineages (haplogroups) seen in different global populations. This would point to the importance of sequence context in the expression of mutations...
2017: PloS One
Naoki Otani, Terushige Toyooka, Kazuya Fujii, Kosuke Kumagai, Satoru Takeuchi, Arata Tomiyama, Yasuaki Nakao, Takuji Yamamoto, Kojiro Wada, Kentaro Mori
OBJECTIVE Microvascular decompression (MVD) is effective for the treatment of trigeminal neuralgia (TN), hemifacial spasm (HFS), and glossopharyngeal neuralgia. The transposition technique is the standard procedure to avoid adhesions and granuloma around the decompression site but is more complex and difficult to perform than the interposition technique. The authors describe a simple and safe MVD transposition procedure they call the "birdlime" technique, which uses a tissue glue-coated collagen sponge soaked with fibrin glue, and the results of this technique...
August 11, 2017: Journal of Neurosurgery
John D Widdrington, Aurora Gomez-Duran, Jannetta S Steyn, Angela Pyle, Marie-Helene Ruchaud-Sparagano, Jonathan Scott, Simon V Baudouin, Anthony J Rostron, John Simpson, Patrick F Chinnery
No abstract text is available yet for this article.
November 2017: Journal of Allergy and Clinical Immunology
Wolfgang H Jost, Rainer Laskawi, Anja Palmowski-Wolfe, Peter P Urban
Hemifacial spasm (HFS) is a frequent disorder characterized by involuntary contractions of those muscles innervated by the facialis nerve on one side of the face. The symptoms can appear as tonic or clonic, intermittent or permanent. Diagnosis is based purely on clinical observation. Differential diagnosis should rely on cranial MRI, which can demonstrate a pathological contact between the nerves and vessels and exclude alternative causation. Often, the symptoms are not marked so that therapy may not be necessary...
April 2017: Fortschritte der Neurologie-Psychiatrie
C V M Verhagen, J Meulstee, H D Boogaarts, W I M Verhagen
BACKGROUND: About 5-15% of people in the Western world will suffer from an extended period of tinnitus during their lifetime. This is often a non-treatable, disabling disorder. Tinnitus can be classified as pulsatile or non-pulsatile. Pulsatile tinnitus can be caused by a treatable neurovascular compression. CASE DESCRIPTION: Here we describe two patients, a 68-year old woman and 40-year old man suffering from pulsatile tinnitus and hemifacial spams due to neurovascular compression of the facial and acoustic nerve in the anterior cranial fossa...
2016: Nederlands Tijdschrift Voor Geneeskunde
Jannetta S Steyn, Peter Andras
The temporal relationship between the activities of neurons in biological neural systems is critically important for the correct delivery of the functionality of these systems. Fine measurement of temporal relationships of neural activities using micro-electrodes is possible but this approach is very limited due to spatial constraints in the context of physiologically valid settings of neural systems. Optical imaging with voltage-sensitive dyes or calcium dyes can provide data about the activity patterns of many neurons in physiologically valid settings, but the data is relatively noisy...
April 2017: Journal of Computational Neuroscience
Michel E Mickael, Ashish Rajput, Jannetta Steyn, Lyle Wiemerslage, Thomas Bürglin
The comparative genomics between different rhodopsin-like family groups (α, β, γ and δ) is not well studied. We used a combination of phylogenetic analysis and statistical genomic methods to compare rhodopsin-like family proteins in species likely symbolic of this family's evolutionary progression. For intra-cluster relationships, we applied mathematical optimisation to enhance the tree search produced by the neighbour joining method (NJ) and compared it with maximum likelihood (ML) method. To infer inter-clusters relationships, we used Needleman-Wunsch analysis (NW), HHsearch, ancestral sequence reconstruction and phylogenetic network analysis...
December 2016: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
Guru D Satyarthee, Shushil Kumar
No abstract text is available yet for this article.
July 2016: Neurology India
Francesco Tomasello, Felice Esposito, Rosaria V Abbritti, Filippo F Angileri, Alfredo Conti, Salvatore M Cardali, Domenico La Torre
BACKGROUND: Microvascular decompression (MVD) represents the most effective and safe surgical option for the treatment of trigeminal neuralgia since it was first popularized by Jannetta 50 years ago. Despite several advances, complications such as cerebellar and vascular injury, hearing loss, muscular atrophy, cerebrospinal fluid (CSF) leak, postoperative cutaneous pain, and sensory disturbances still occur and may negatively affect the outcome. We propose some technical nuances of the surgical procedure that were used in our recent series...
October 2016: World Neurosurgery
Raymond F Sekula
No abstract text is available yet for this article.
October 2016: World Neurosurgery
D A Rzaev, E V Kulikova, G I Moysak, E I Voronina, T A Ageeva
The use of a Teflon implant for Jannetta surgery in patients with trigeminal neuralgia is complicated in rare cases by the development of a Teflon granuloma and can cause recurrent facial pain. The article presents a clinical case of a Teflon granuloma developed after microvascular decompression of the trigeminal nerve root, describes the surgical findings and histological picture, and analyzes the literature, causes of granuloma development, and recommendations for treatment of these patients.
2016: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
Willem Alexander Kernkamp, Wiebe Christiaan Verra, Bart Godefridus Pijls, Jan Wilhelmus Schoones, Henrica Maria Jannetta van der Linden, Rob Gerardus Henricus Hubertus Nelissen
PURPOSE: Arthrodesis (AD) of the knee reduces pain and provides stability, but has severe functional and social limitations. There has been ample discussion on the value of a conversion of an AD to a total knee arthroplasty (TKA). The aim of this study was to perform a review and meta-analysis of the current literature on conversion of an AD to TKA and assess clinical outcome, complication rate, surgical technique and overall patient-related outcome measures. METHODS: PubMed, Embase, Web of Science, Cochrane, CENTRAL, CINAHL, Academic Search Premier, ScienceDirect and searching by hand for papers on conversion of AD of the knee to TKA...
October 2016: International Orthopaedics
Abd A Alhasan, Osagie G Izuogu, Haya H Al-Balool, Jannetta S Steyn, Amanda Evans, Maria Colzani, Cedric Ghevaert, Joanne C Mountford, Lamin Marenah, David J Elliott, Mauro Santibanez-Koref, Michael S Jackson
In platelets, splicing and translation occur in the absence of a nucleus. However, the integrity and stability of mRNAs derived from megakaryocyte progenitor cells remain poorly quantified on a transcriptome-wide level. As circular RNAs (circRNAs) are resistant to degradation by exonucleases, their abundance relative to linear RNAs can be used as a surrogate marker for mRNA stability in the absence of transcription. Here we show that circRNAs are enriched in human platelets 17- to 188-fold relative to nucleated tissues and 14- to 26-fold relative to samples digested with RNAse R to selectively remove linear RNA...
March 3, 2016: Blood
Angela C Telfer, Monica R Young, Jenna Quinn, Kate Perez, Crystal N Sobel, Jayme E Sones, Valerie Levesque-Beaudin, Rachael Derbyshire, Jose Fernandez-Triana, Rodolphe Rougerie, Abinah Thevanayagam, Adrian Boskovic, Alex V Borisenko, Alex Cadel, Allison Brown, Anais Pages, Anibal H Castillo, Annegret Nicolai, Barb Mockford Glenn Mockford, Belén Bukowski, Bill Wilson, Brock Trojahn, Carole Ann Lacroix, Chris Brimblecombe, Christoper Hay, Christmas Ho, Claudia Steinke, Connor P Warne, Cristina Garrido Cortes, Daniel Engelking, Danielle Wright, Dario A Lijtmaer, David Gascoigne, David Hernandez Martich, Derek Morningstar, Dirk Neumann, Dirk Steinke, Donna DeBruin Marco DeBruin, Dylan Dobias, Elizabeth Sears, Ellen Richard, Emily Damstra, Evgeny V Zakharov, Frederic Laberge, Gemma E Collins, Gergin A Blagoev, Gerrie Grainge, Graham Ansell, Greg Meredith, Ian Hogg, Jaclyn McKeown, Janet Topan, Jason Bracey, Jerry Guenther, Jesse Sills-Gilligan, Joseph Addesi, Joshua Persi, Kara K S Layton, Kareina D'Souza, Kencho Dorji, Kevin Grundy, Kirsti Nghidinwa, Kylee Ronnenberg, Kyung Min Lee, Linxi Xie, Liuqiong Lu, Lyubomir Penev, Mailyn Gonzalez, Margaret E Rosati, Mari Kekkonen, Maria Kuzmina, Marianne Iskandar, Marko Mutanen, Maryam Fatahi, Mikko Pentinsaari, Miriam Bauman, Nadya Nikolova, Natalia V Ivanova, Nathaniel Jones, Nimalka Weerasuriya, Norman Monkhouse, Pablo D Lavinia, Paul Jannetta, Priscila E Hanisch, R Troy McMullin, Rafael Ojeda Flores, Raphaëlle Mouttet, Reid Vender, Renee N Labbee, Robert Forsyth, Rob Lauder, Ross Dickson, Ruth Kroft, Scott E Miller, Shannon MacDonald, Sishir Panthi, Stephanie Pedersen, Stephanie Sobek-Swant, Suresh Naik, Tatsiana Lipinskaya, Thanushi Eagalle, Thibaud Decaëns, Thibault Kosuth, Thomas Braukmann, Tom Woodcock, Tomas Roslin, Tony Zammit, Victoria Campbell, Vlad Dinca, Vlada Peneva, Paul D N Hebert, Jeremy R deWaard
BACKGROUND: Comprehensive biotic surveys, or 'all taxon biodiversity inventories' (ATBI), have traditionally been limited in scale or scope due to the complications surrounding specimen sorting and species identification. To circumvent these issues, several ATBI projects have successfully integrated DNA barcoding into their identification procedures and witnessed acceleration in their surveys and subsequent increase in project scope and scale. The Biodiversity Institute of Ontario partnered with the rare Charitable Research Reserve and delegates of the 6th International Barcode of Life Conference to complete its own rapid, barcode-assisted ATBI of an established land trust in Cambridge, Ontario, Canada...
2015: Biodiversity Data Journal
Marc Sindou, Mohamed Mahmoudi, Andrei Brînzeu
OBJECT: In spite of solid anatomical and physiological arguments and the promising results of Jannetta in the 1970s, treating essential hypertension by microvascular decompression (MVD) of the brainstem has not gained acceptance as a mainstream technique. The main reason has been a lack of established selection criteria. Because of this, the authors' attempts have been limited to patients referred for MVD for hemifacial spasm (HFS) who also had hypertension likely to be related to neurovascular compression (NVC)...
December 2015: Journal of Neurosurgery
Geert E Smid, Rolf J Kleber, Simone M de la Rie, Jannetta B A Bos, Berthold P R Gersons, Paul A Boelen
BACKGROUND: Traumatic events such as disasters, accidents, war, or criminal violence are often accompanied by the loss of loved ones, and may then give rise to traumatic grief. Traumatic grief refers to a clinical diagnosis of persistent complex bereavement disorder (PCBD) with comorbid (symptoms of) posttraumatic stress disorder (PTSD) and/or major depressive disorder (MDD) following confrontation with a traumatic loss. Trauma survivors, who are frequently from different cultural backgrounds, have often experienced multiple losses and ambiguous loss (missing family members or friends)...
2015: European Journal of Psychotraumatology
Philip M Kluin, Anton W Langerak, Jannetta Beverdam-Vincent, Willemina R R Geurts-Giele, Lydia Visser, Bea Rutgers, Ed Schuuring, Joop Van Baarlen, King H Lam, Kees Seldenrijk, Robby E Kibbelaar, Peter de Wit, Arjan Diepstra, Stefano Rosati, Max M van Noesel, C Michel Zwaan, Jarmo C B Hunting, Mels Hoogendoorn, Ellen J van der Gaag, Joost W J van Esser, Eveline de Bont, Hanneke C Kluin-Nelemans, Rik H Winter, Jerome R Lo Ten Foe, Adri G M van der Zanden
Many hyperplasias and lymphomas of marginal zone B-cells are associated with infection. We identified six children and one adolescent with cervical lymphadenopathy showing prominent polyclonal nodal marginal zone hyperplasia (pNMZH) and four adolescents with monoclonal paediatric nodal marginal zone lymphoma (pNMZL). The clonality status was assessed using BIOMED-2-IG PCR analysis. Haemophilus influenzae was identified in all six cases of pNMZH that could be tested by direct culture (N = 3) or a very sensitive PCR for the H...
July 2015: Journal of Pathology
R Chiaramonte, M Bonfiglio, A D'Amore, I Chiaramonte
Hemifacial spasm (HFS) is a facial movement disorder characterized by involuntary, unilateral and intermittent contractions of the facial muscles. It is one of the syndromes related to neurovascular conflict, first described by Jannetta et al. in 1979. Typically, HFS is due to pulsatile compression by the anterior inferior cerebellar artery. We describe a rare case of left developmental venous anomaly in a 59-year-old man referred to us with a six-month history of left-sided HFS. We performed an MR study of the brain and cerebellopontine angles, which demonstrated a compression of the ipsilateral facial nerve by the developmental venous anomaly...
April 2013: Neuroradiology Journal
C Brunot-Gohin, J-L Duval, E-E Azogui, R Jannetta, I Pezron, D Laurent-Maquin, S C Gangloff, C Egles
OBJECTIVE: Ceramics are widely used materials for prosthesis, especially in dental fields. Despite multiple biomedical applications, little is known about ceramic surface modifications and the resulting cell behavior at its contact. The aim of this study is to evaluate the biological response of polished versus glazed surface treatments on lithium disilicate dental ceramic. METHODS: We studied a lithium disilicate ceramic (IPS e.max(®) Press, Ivoclar Vivadent) with 3 different surface treatments: raw surface treatment, hand polished surface treatment, and glazed surface treatment (control samples are Thermanox(®), Nunc)...
September 2013: Dental Materials: Official Publication of the Academy of Dental Materials
Jennifer L Busch, Thomas M Bridges, Robyn Richie-Jannetta, Brian P Hollett, Sharron H Francis, Jackie D Corbin
Ser-64, an autophosphorylation site in the autoinhibitory subdomain of cGMP-dependent protein kinase type I-alpha (PKGI-alpha), lowers affinity for cGMP and suppresses catalytic activity (1). Using the structure of homologous cAMP-dependent protein kinase as a model, three conserved residues (Gln-401, His-404, Cys-518) in the PKGI-alpha catalytic site are predicted to be juxtaposed to Ser-64 (2). Individual point mutants (Q401A, H404A and C518A) and a double mutant (S64A/H404A) have been generated. cGMP or cAMP affinities (K(a)) of each mutant protein for phosphotransferase activation and allosteric (3H)cGMP-binding affinity (K(D)) of each mutant protein are significantly improved over those of wild-type (WT) PKGI-alpha...
2013: Frontiers in Bioscience (Scholar Edition)
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