Carla B Mellough, Roman Bauer, Joseph Collin, Birthe Dorgau, Darin Zerti, David W P Dolan, Carl M Jones, Osagie G Izuogu, Min Yu, Dean Hallam, Jannetta S Steyn, Kathryn White, David H Steel, Mauro Santibanez-Koref, David J Elliott, Michael S Jackson, Susan Lindsay, Sushma Grellscheid, Majlinda Lako
The scarcity of embryonic/foetal material as a resource for direct study means that there is still limited understanding of human retina development. Here, we present an integrated transcriptome analysis combined with immunohistochemistry in human eye and retinal samples from 4 to 19 post-conception weeks. This analysis reveals three developmental windows with specific gene expression patterns that informed the sequential emergence of retinal cell types and enabled identification of stage-specific cellular and biological processes, and transcriptional regulators...
January 29, 2019: Development