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Auditory Brainstem Implant

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https://www.readbyqxmd.com/read/29445111/fluvastatin-protects-cochleae-from-damage-by-high-level-noise
#1
Claus-Peter Richter, Hunter Young, Sonja V Richter, Virginia Smith-Bronstein, Stuart R Stock, Xianghui Xiao, Carmen Soriano, Donna S Whitlon
Exposure to noise and ototoxic drugs are responsible for much of the debilitating hearing loss experienced by about 350 million people worldwide. Beyond hearing aids and cochlear implants, there have been no other FDA approved drug interventions established in the clinic that would either protect or reverse the effects of hearing loss. Using Auditory Brainstem Responses (ABR) in a guinea pig model, we demonstrate that fluvastatin, an inhibitor of HMG-CoA reductase, the rate-limiting enzyme of the mevalonate pathway, protects against loss of cochlear function initiated by high intensity noise...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29361882/awake-craniotomy-for-assisting-placement-of-auditory-brainstem-implant-in-nf2-patients
#2
Qiangyi Zhou, Zhijun Yang, Zhenmin Wang, Bo Wang, Xingchao Wang, Chi Zhao, Shun Zhang, Tao Wu, Peng Li, Shiwei Li, Fu Zhao, Pinan Liu
OBJECTIVES: Auditory brainstem implants (ABIs) may be the only opportunity for patients with NF2 to regain some sense of hearing sensation. However, only a very small number of individuals achieved open-set speech understanding and high sentence scores. Suboptimal placement of the ABI electrode array over the cochlear nucleus may be one of main factors for poor auditory performance. In the current study, we present a method of awake craniotomy to assist with ABI placement. METHODS: Awake surgery and hearing test via the retrosigmoid approach were performed for vestibular schwannoma resections and auditory brainstem implantations in four patients with NF2...
January 23, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29320320/mr-imaging-and-cochlear-implants-with-retained-internal-magnets-reducing-artifacts-near-highly-inhomogeneous-magnetic-fields
#3
Heidi A Edmonson, Matthew L Carlson, Alice C Patton, Robert E Watson
The number of patients receiving cochlear implants and auditory brainstem implants for severe to profound sensorineural hearing loss has rapidly increased. These implants consist of an internal component implanted between the skull and the temporal scalp and an external removable speech processor unit. A small magnet within the internal component is commonly used to hold the external speech processor unit in place. Several cochlear implant models have recently received U.S. Food and Drug Administration and European Economic Area regulatory approval to allow magnetic resonance (MR) imaging examinations to be performed under certain specified conditions...
January 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29305691/the-capos-mutation-in-atp1a3-alters-na-k-atpase-function-and-results-in-auditory-neuropathy-which-has-implications-for-management
#4
Lisbeth Tranebjærg, Nicola Strenzke, Sture Lindholm, Nanna D Rendtorff, Hanne Poulsen, Himanshu Khandelia, Wojciech Kopec, Troels J Brünnich Lyngbye, Christian Hamel, Cecile Delettre, Beatrice Bocquet, Michael Bille, Hanne H Owen, Toke Bek, Hanne Jensen, Karen Østergaard, Claes Möller, Linda Luxon, Lucinda Carr, Louise Wilson, Kaukab Rajput, Tony Sirimanna, Katherine Harrop-Griffiths, Shamima Rahman, Barbara Vona, Julia Doll, Thomas Haaf, Oliver Bartsch, Hendrik Rosewich, Tobias Moser, Maria Bitner-Glindzicz
Cerebellar ataxia, areflexia, pes cavus, optic atrophy and sensorineural hearing impairment (CAPOS) is a rare clinically distinct syndrome caused by a single dominant missense mutation, c.2452G>A, p.Glu818Lys, in ATP1A3, encoding the neuron-specific alpha subunit of the Na+/K+-ATPase α3. Allelic mutations cause the neurological diseases rapid dystonia Parkinsonism and alternating hemiplegia of childhood, disorders which do not encompass hearing or visual impairment. We present detailed clinical phenotypic information in 18 genetically confirmed patients from 11 families (10 previously unreported) from Denmark, Sweden, UK and Germany indicating a specific type of hearing impairment-auditory neuropathy (AN)...
January 5, 2018: Human Genetics
https://www.readbyqxmd.com/read/29287891/characteristics-of-electrically-evoked-auditory-brainstem-responses-in-patients-with-cochlear-nerve-canal-stenosis-receiving-cochlear-implants
#5
Zhenxiao Wang, Yun Liu, Line Wang, Xixi Shen, Shuguang Han, Wei Wang, Fenqi Gao, Wenqi Liang, Kevin A Peng
OBJECTIVE: To explore the characteristics of the electrically evoked auditory brainstem responses (EABR) in children with cochlear nerve canal stenosis (CNCs) following cochlear implantation (CI), and the EABR thresholds in children with stenotic versus normal cochlear nerve canals. METHOD: Sixteen children with profound sensorineural hearing loss were included in this study: 8 with CNCs (CNCs group) and 8 with normal cochlear nerve canals (control group). All children underwent cochlear implantation with full insertion of all electrodes...
January 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29287861/bilateral-cochlear-implantation-or-bimodal-listening-in-the-paediatric-population-retrospective-analysis-of-decisive-criteria
#6
Cleo M C Dhondt, Freya K R Swinnen, Ingeborg J M Dhooge
INTRODUCTION: In children with bilateral severe to profound hearing loss, bilateral hearing can be achieved by either bimodal stimulation (CIHA) or bilateral cochlear implantation (BICI). The aim of this study was to analyse the audiologic test protocol that is currently applied to make decisions regarding the bilateral hearing modality in the paediatric population. METHODS: Pre- and postoperative audiologic test results of 21 CIHA, 19 sequential BICI and 12 simultaneous BICI children were examined retrospectively...
January 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29279723/diagnostics-and-therapy-of-vestibular-schwannomas-an-interdisciplinary-challenge
#7
REVIEW
Steffen Rosahl, Christopher Bohr, Michael Lell, Klaus Hamm, Heinrich Iro
Vestibular schwannomas (VS) expand slowly in the internal auditory canal, in the cerebellopontine angle, inside the cochlear and the labyrinth. Larger tumors can displace and compress the brainstem. With an annual incidence of 1:100,000 vestibular schwannoma represent 6-7% of all intracranial tumors. In the cerebellopontine angle they are by far the most neoplasm with 90% of all lesions located in this region. Magnetic resonance imaging (MRI), audiometry, and vestibular diagnostics are the mainstays of the clinical workup for patients harboring tumors...
2017: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
https://www.readbyqxmd.com/read/29251689/the-summating-potential-is-a-reliable-marker-of-electrode-position-in-electrocochleography-cochlear-implant-as-a-theragnostic-probe
#8
Victor Helmstaedter, Thomas Lenarz, Peter Erfurt, Andrej Kral, Peter Baumhoff
OBJECTIVE: For the increasing number of cochlear implantations in subjects with residual hearing, hearing preservation, and thus the prevention of implantation trauma, is crucial. A method for monitoring the intracochlear position of a cochlear implant (CI) and early indication of imminent cochlear trauma would help to assist the surgeon to achieve this goal. The aim of this study was to evaluate the reliability of the different electric components recorded by an intracochlear electrocochleography (ECochG) as markers for the cochleotopic position of a CI...
December 14, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/29236269/the-value-of-assr-threshold-based-bilateral-hearing-aid-fitting-in-children-with-difficult-or-unreliable-behavioral-audiometry
#9
Petros V Vlastarakos, Alexandra Vasileiou, Thomas P Nikolopoulos
We conducted an analysis to assess the relative contribution of auditory brainstem response (ABR) testing and auditory steady-state response (ASSR) testing in providing appropriate hearing aid fitting in hearing-impaired children with difficult or unreliable behavioral audiometry. Of 150 infants and children who had been referred to us for hearing assessment as part of a neonatal hearing screening and cochlear implantation program, we identified 5 who exhibited significant discrepancies between click-ABR and ASSR testing results and difficult or unreliable behavioral audiometry...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29186598/favorable-long-term-functional-outcomes-and-safety-of-auditory-brainstem-implants-in-nontumor-patients
#10
Na Young Jung, Minsoo Kim, Won Seok Chang, Hyun Ho Jung, Jae Young Choi, Jin Woo Chang
BACKGROUND: Auditory brainstem implants (ABIs) were designed to restore hearing in deaf patients with auditory tumors or those unable to receive cochlear implants. Although ABIs may help some patients, their long-term outcomes have been rarely studied. OBJECTIVE: To assess the long-term benefits and safety of ABIs in nontumor patients with sensorineural hearing loss (SNHL). METHODS: We retrospectively reviewed the histories of 15 deaf patients (8 females, 7 males; mean age, 15...
December 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29135872/the-role-of-auditory-evoked-potentials-in-the-context-of-cochlear-implant-provision
#11
Sebastian Hoth, Oliver Christian Dziemba
: Auditory evoked potentials (AEP) are highly demanded during the whole process of equipping patients with cochlear implants (CI). They play an essential role in preoperative diagnostics, intraoperative testing, and postoperative monitoring of auditory performance and success. The versatility of AEP's is essentially enhanced by their property to be evokable by acoustic as well as electric stimuli. Thus, the electric responses of the auditory system following acoustic stimulation and recorded by the conventional surface technique as well as by transtympanic derivation from the promontory (Electrocochleography [ECochG]) are used for the quantitative determination of hearing loss and, additionally, electrically evoked compound actions potentials (ECAP) can be recorded with the intracochlear electrodes of the implant just adjacent to the stimulation electrode to check the functional integrity of the device and its coupling to the auditory system...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29122298/evoked-potential-and-eeg-study-of-the-neurotoxicity-of-hydramethylnon-in-rats
#12
George M Strain
The objective of the study was to assess the neurotoxicity, using electrodiagnostic tests, of hydramethylnon (Amdro, AC 217,300), an insecticide marketed for the treatment of red imported fire ants, cockroaches, and other insects. Animals were male Fisher 344 albino rats and Long-Evans hooded rats. Brainstem auditory, visual, and somatosensory evoked potentials (BAER, VEP, SEP) and electroencephalograms (EEG) were recorded from implanted screw electrodes before and at multiple time points through day 10 after a single oral dose of hydramethylnon (at 50% or 75% of the LD50) plus vehicle, or vehicle alone...
October 31, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29108871/effects-of-the-cannabinoid-cb1-agonist-acea-on-salicylate-ototoxicity-hyperacusis-and-tinnitus-in-guinea-pigs
#13
Joel I Berger, Ben Coomber, Samantha Hill, Steve P H Alexander, William Owen, Alan R Palmer, Mark N Wallace
Cannabinoids have been suggested as a therapeutic target for a variety of brain disorders. Despite the presence of their receptors throughout the auditory system, little is known about how cannabinoids affect auditory function. We sought to determine whether administration of arachidonyl-2'-chloroethylamide (ACEA), a highly-selective CB1 agonist, could attenuate a variety of auditory effects caused by prior administration of salicylate, and potentially treat tinnitus. We recorded cortical resting-state activity, auditory-evoked cortical activity and auditory brainstem responses (ABRs), from chronically-implanted awake guinea pigs, before and after salicylate + ACEA...
October 31, 2017: Hearing Research
https://www.readbyqxmd.com/read/29106852/postoperative-objective-detecting-techniques-for-cochlear-implant-children-with-inner-ear-malformation
#14
Xiao-Feng Qiao, Xin Li, Qiang-Wei Zhang, Tong-Li Li, Dong Wang
OBJECTIVES: This study aims to investigate the changing characteristics and rules of electrically-evoked auditory brainstem response (EABR), electrically-evoked stapedius reflex threshold (ESRT) and neural response telemetry (NRT) after cochlear implant in children with inner ear malformation, and guide postoperative equipment debug. METHODS: A total of 88 children with either normal cochlea (control group) or inner ear malformation (test group) received Australian 24 multi-channel cochlear implants...
November 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29098103/cochlear-implantation-in-patients-with-keratitis-ichthyosis-deafness-syndrome-a-report-of-two-cases
#15
Birgul Gumus, Armagan Incesulu, Mehmet Ozgur Pinarbasli
Background: Keratitis-ichthyosis-deafness (KID) syndrome is a syndrome which presents with hearing loss and visual and keratinization disorders. In such patients, hearing aids cannot be effectively used in the rehabilitation of hearing loss because of the frequent blockage of the external ear canal with epithelial debris and due to dry and tense skin of the external ear canal. Moreover, severe or profound hearing loss also limits the benefits gained from the conventional hearing aids...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/29089185/cannula-based-drug-delivery-to-the-guinea-pig-round-window-causes-a-lasting-hearing-loss-that-may-be-temporarily-mitigated-by-bdnf
#16
Phillip J P Sale, Aaron Uschakov, Tasfia Saief, David P Rowe, Carla J Abbott, Chi D Luu, Amy J Hampson, Stephen J O'Leary, David J Sly
Sustained local delivery of drugs to the inner ear may be required for future regenerative and protective strategies. The round window is surgically accessible and a promising delivery route. To be viable, a delivery system should not cause hearing loss. This study determined the effect on hearing of placing a drug-delivery microcatheter on to the round window, and delivering either artificial perilymph (AP) or brain-derived neurotrophic factor (BDNF) via this catheter with a mini-osmotic pump. Auditory brainstem responses (ABRs) were monitored for 4 months after surgery, while the AP or BDNF was administered for the first month...
October 28, 2017: Hearing Research
https://www.readbyqxmd.com/read/29076926/usefulness-of-electrical-auditory-brainstem-responses-to-assess-the-functionality-of-the-cochlear-nerve-using-an-intracochlear-test-electrode
#17
Luis Lassaletta, Marek Polak, Jan Huesers, Miguel Díaz-Gómez, Miryam Calvino, Isabel Varela-Nieto, Javier Gavilán
OBJECTIVE: To use an intracochlear test electrode to assess the integrity and the functionality of the auditory nerve in cochlear implant (CI) recipients and to compare electrical auditory brainstem responses (eABR) via the test electrode with the eABR responses with the CI. SETTING: Otolaryngology department, tertiary referral hospital. PATIENTS: Ten subjects (age at implantation 55 yr, range, 19-72) were subsequently implanted with a MED-EL CONCERTO CI on the side without any useful residual hearing...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29060273/auditory-responses-to-short-wavelength-infrared-neural-stimulation-of-the-rat-cochlear-nucleus
#18
Bin Jiang, Nan Xia, Xing Wang, Ning Hu, Xiao Y Wu, Yi Zhou, Wen S Hou
Pulsed Infrared laser is well-known for its high spatial resolution and contact-free stimulation mode. In order to improve the current auditory brainstem implants (ABI), 980 nm-short-wavelength infrared light was applied to stimulate the cochlear nucleus of rats. Single neural activity from contralateral inferior colliculus was recorded during laser stimulation. Animal experimental results showed that 980 nm laser could not directly activate neurons in cochlear nucleus and a photo-acoustic response was observed during stimulation, however, 980 nm laser produces an inhibitory effect on neural responses to sounds; After we added carbon nanoparticles onto the surface of animal cochlear nucleus, 980 nm laser could directly stimulate neurons and no interference between adjacent recording channels was observed...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29036751/-diagnosis-and-management-of-vestibular-schwannomas-an-interdisciplinary-challenge
#19
Steffen Rosahl, Christopher Bohr, Michael Lell, Klaus Hamm, Heinrich Iro
Vestibular schwannomas expand slowly in the internal auditory canal, in the cerebellopontine angle, inside the cochlear and the labyrinth. Larger tumors can displace and compress the brainstem. With an annual incidence of 1:100 000 vestibular schwannoma represent 6-7% of all intracranial tumors. In the cerebellopontine angle they are by far the most neoplasm with 90% of all lesions located in this region. Magnetic resonance imaging (MRI), audiometry, and vestibular diagnostics are the mainstays of the clinical workup for patients harboring tumors...
April 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29023243/pediatric-auditory-brainstem-implantation-surgical-electrophysiologic-and-behavioral-outcomes
#20
Holly F B Teagle, Lillian Henderson, Shuman He, Matthew G Ewend, Craig A Buchman
OBJECTIVES: The objectives of this study were to demonstrate the safety of auditory brainstem implant (ABI) surgery and document the subsequent development of auditory and spoken language skills in children without neurofibromatosis type II (NFII). DESIGN: A prospective, single-subject observational study of ABI in children without NFII was undertaken at the University of North Carolina at Chapel Hill. Five children were enrolled under an investigational device exemption sponsored by the investigators...
October 11, 2017: Ear and Hearing
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