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Auditory Brainstem Implant

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https://www.readbyqxmd.com/read/29186598/favorable-long-term-functional-outcomes-and-safety-of-auditory-brainstem-implants-in-nontumor-patients
#1
Na Young Jung, Minsoo Kim, Won Seok Chang, Hyun Ho Jung, Jae Young Choi, Jin Woo Chang
BACKGROUND: Auditory brainstem implants (ABIs) were designed to restore hearing in deaf patients with auditory tumors or those unable to receive cochlear implants. Although ABIs may help some patients, their long-term outcomes have been rarely studied. OBJECTIVE: To assess the long-term benefits and safety of ABIs in nontumor patients with sensorineural hearing loss (SNHL). METHODS: We retrospectively reviewed the histories of 15 deaf patients (8 females, 7 males; mean age, 15...
December 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29135872/the-role-of-auditory-evoked-potentials-in-the-context-of-cochlear-implant-provision
#2
Sebastian Hoth, Oliver Christian Dziemba
: Auditory evoked potentials (AEP) are highly demanded during the whole process of equipping patients with cochlear implants (CI). They play an essential role in preoperative diagnostics, intraoperative testing, and postoperative monitoring of auditory performance and success. The versatility of AEP's is essentially enhanced by their property to be evokable by acoustic as well as electric stimuli. Thus, the electric responses of the auditory system following acoustic stimulation and recorded by the conventional surface technique as well as by transtympanic derivation from the promontory (Electrocochleography [ECochG]) are used for the quantitative determination of hearing loss and, additionally, electrically evoked compound actions potentials (ECAP) can be recorded with the intracochlear electrodes of the implant just adjacent to the stimulation electrode to check the functional integrity of the device and its coupling to the auditory system...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29122298/evoked-potential-and-eeg-study-of-the-neurotoxicity-of-hydramethylnon-in-rats
#3
George M Strain
The objective of the study was to assess the neurotoxicity, using electrodiagnostic tests, of hydramethylnon (Amdro, AC 217,300), an insecticide marketed for the treatment of red imported fire ants, cockroaches, and other insects. Animals were male Fisher 344 albino rats and Long-Evans hooded rats. Brainstem auditory, visual, and somatosensory evoked potentials (BAER, VEP, SEP) and electroencephalograms (EEG) were recorded from implanted screw electrodes before and at multiple time points through day 10 after a single oral dose of hydramethylnon (at 50% or 75% of the LD50) plus vehicle, or vehicle alone...
October 31, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29108871/effects-of-the-cannabinoid-cb1-agonist-acea-on-salicylate-ototoxicity-hyperacusis-and-tinnitus-in-guinea-pigs
#4
Joel I Berger, Ben Coomber, Samantha Hill, Steve P H Alexander, William Owen, Alan R Palmer, Mark N Wallace
Cannabinoids have been suggested as a therapeutic target for a variety of brain disorders. Despite the presence of their receptors throughout the auditory system, little is known about how cannabinoids affect auditory function. We sought to determine whether administration of arachidonyl-2'-chloroethylamide (ACEA), a highly-selective CB1 agonist, could attenuate a variety of auditory effects caused by prior administration of salicylate, and potentially treat tinnitus. We recorded cortical resting-state activity, auditory-evoked cortical activity and auditory brainstem responses (ABRs), from chronically-implanted awake guinea pigs, before and after salicylate + ACEA...
October 31, 2017: Hearing Research
https://www.readbyqxmd.com/read/29106852/postoperative-objective-detecting-techniques-for-cochlear-implant-children-with-inner-ear-malformation
#5
Xiao-Feng Qiao, Xin Li, Qiang-Wei Zhang, Tong-Li Li, Dong Wang
OBJECTIVES: This study aims to investigate the changing characteristics and rules of electrically-evoked auditory brainstem response (EABR), electrically-evoked stapedius reflex threshold (ESRT) and neural response telemetry (NRT) after cochlear implant in children with inner ear malformation, and guide postoperative equipment debug. METHODS: A total of 88 children with either normal cochlea (control group) or inner ear malformation (test group) received Australian 24 multi-channel cochlear implants...
November 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29098103/cochlear-implantation-in-patients-with-keratitis-ichthyosis-deafness-syndrome-a-report-of-two-cases
#6
Birgul Gumus, Armagan Incesulu, Mehmet Ozgur Pinarbasli
Background: Keratitis-ichthyosis-deafness (KID) syndrome is a syndrome which presents with hearing loss and visual and keratinization disorders. In such patients, hearing aids cannot be effectively used in the rehabilitation of hearing loss because of the frequent blockage of the external ear canal with epithelial debris and due to dry and tense skin of the external ear canal. Moreover, severe or profound hearing loss also limits the benefits gained from the conventional hearing aids...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/29089185/cannula-based-drug-delivery-to-the-guinea-pig-round-window-causes-a-lasting-hearing-loss-that-may-be-temporarily-mitigated-by-bdnf
#7
Phillip J P Sale, Aaron Uschakov, Tasfia Saief, David P Rowe, Carla J Abbott, Chi D Luu, Amy J Hampson, Stephen J O'Leary, David J Sly
Sustained local delivery of drugs to the inner ear may be required for future regenerative and protective strategies. The round window is surgically accessible and a promising delivery route. To be viable, a delivery system should not cause hearing loss. This study determined the effect on hearing of placing a drug-delivery microcatheter on to the round window, and delivering either artificial perilymph (AP) or brain-derived neurotrophic factor (BDNF) via this catheter with a mini-osmotic pump. Auditory brainstem responses (ABRs) were monitored for 4 months after surgery, while the AP or BDNF was administered for the first month...
October 28, 2017: Hearing Research
https://www.readbyqxmd.com/read/29076926/usefulness-of-electrical-auditory-brainstem-responses-to-assess-the-functionality-of-the-cochlear-nerve-using-an-intracochlear-test-electrode
#8
Luis Lassaletta, Marek Polak, Jan Huesers, Miguel Díaz-Gómez, Miryam Calvino, Isabel Varela-Nieto, Javier Gavilán
OBJECTIVE: To use an intracochlear test electrode to assess the integrity and the functionality of the auditory nerve in cochlear implant (CI) recipients and to compare electrical auditory brainstem responses (eABR) via the test electrode with the eABR responses with the CI. SETTING: Otolaryngology department, tertiary referral hospital. PATIENTS: Ten subjects (age at implantation 55 yr, range, 19-72) were subsequently implanted with a MED-EL CONCERTO CI on the side without any useful residual hearing...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29060273/auditory-responses-to-short-wavelength-infrared-neural-stimulation-of-the-rat-cochlear-nucleus
#9
Bin Jiang, Nan Xia, Xing Wang, Ning Hu, Xiao Y Wu, Yi Zhou, Wen S Hou
Pulsed Infrared laser is well-known for its high spatial resolution and contact-free stimulation mode. In order to improve the current auditory brainstem implants (ABI), 980 nm-short-wavelength infrared light was applied to stimulate the cochlear nucleus of rats. Single neural activity from contralateral inferior colliculus was recorded during laser stimulation. Animal experimental results showed that 980 nm laser could not directly activate neurons in cochlear nucleus and a photo-acoustic response was observed during stimulation, however, 980 nm laser produces an inhibitory effect on neural responses to sounds; After we added carbon nanoparticles onto the surface of animal cochlear nucleus, 980 nm laser could directly stimulate neurons and no interference between adjacent recording channels was observed...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29036751/-diagnosis-and-management-of-vestibular-schwannomas-an-interdisciplinary-challenge
#10
Steffen Rosahl, Christopher Bohr, Michael Lell, Klaus Hamm, Heinrich Iro
Vestibular schwannomas expand slowly in the internal auditory canal, in the cerebellopontine angle, inside the cochlear and the labyrinth. Larger tumors can displace and compress the brainstem. With an annual incidence of 1:100 000 vestibular schwannoma represent 6-7% of all intracranial tumors. In the cerebellopontine angle they are by far the most neoplasm with 90% of all lesions located in this region. Magnetic resonance imaging (MRI), audiometry, and vestibular diagnostics are the mainstays of the clinical workup for patients harboring tumors...
April 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29023243/pediatric-auditory-brainstem-implantation-surgical-electrophysiologic-and-behavioral-outcomes
#11
Holly F B Teagle, Lillian Henderson, Shuman He, Matthew G Ewend, Craig A Buchman
OBJECTIVES: The objectives of this study were to demonstrate the safety of auditory brainstem implant (ABI) surgery and document the subsequent development of auditory and spoken language skills in children without neurofibromatosis type II (NFII). DESIGN: A prospective, single-subject observational study of ABI in children without NFII was undertaken at the University of North Carolina at Chapel Hill. Five children were enrolled under an investigational device exemption sponsored by the investigators...
October 11, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28968281/the-electrically-evoked-auditory-change-complex-evoked-by-temporal-gaps-using-cochlear-implants-or-auditory-brainstem-implants-in-children-with-cochlear-nerve-deficiency
#12
Shuman He, Tyler C McFayden, Bahar S Shahsavarani, Holly F B Teagle, Matthew Ewend, Lillian Henderson, Craig A Buchman
OBJECTIVES: This study aimed to (1) establish the feasibility of measuring the electrically evoked auditory change complex (eACC) in response to temporal gaps in children with cochlear nerve deficiency (CND) who are using cochlear implants (CIs) and/or auditory brainstem implants (ABIs); and (2) explore the association between neural encoding of, and perceptual sensitivity to, temporal gaps in these patients. DESIGN: Study participants included 5 children (S1 to S5) ranging in age from 3...
September 29, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28964288/the-value-of-intraoperative-eabrs-in-auditory-brainstem-implantation
#13
Abbas Anwar, Alison Singleton, Yixin Fang, Binhuan Wang, William Shapiro, J Thomas Roland, Susan B Waltzman
OBJECTIVE: To compare the intraoperative electrically evoked auditory brainstem response (EABR) morphologies between neurofibromatosis II (NF2) adult auditory brainstem implant (ABI) recipients who had auditory percepts post-operatively and those who did not and between NF2 adult ABI recipients and non-NF2 pediatric ABI recipients. METHODS: This was a retrospective case series at a single tertiary academic referral center examining all ABI recipients from 1994 to 2016, which included 34 NF2 adults and 11 non-NF2 children...
October 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28925013/an-animal-model-of-deep-brain-stimulation-for-treating-tinnitus-a-proof-of-concept-study
#14
Syed F Ahsan, Hao Luo, Jinsheng Zhang, Eric Kim, Yong Xu
OBJECTIVE: This proof-of-concept study aimed to demonstrate therapeutic effects of deep brain stimulation (DBS) on noise-induced tinnitus. STUDY DESIGN: Experimental animal study. METHODS: After Institutional Animal Care and Use Committee approval, nine adult rats were implanted in the caudate nucleus with custom-made electrode array. The rats were exposed to noise to induce tinnitus. Auditory brainstem response was performed to evaluate hearing threshold changes...
September 19, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28891823/longitudinal-changes-in-electrically-evoked-auditory-event-related-potentials-in-children-with-auditory-brainstem-implants-preliminary-results-recorded-over-3-years
#15
Shuman He, Holly F B Teagle, Tyler C McFayden, Matthew Ewend, Lillian Henderson, Nancy He, Craig A Buchman
OBJECTIVES: This preliminary study aimed (1) to assess longitudinal changes in electrically evoked auditory event-related potentials (eERPs) in children with auditory brainstem implants (ABIs) and (2) to explore whether these changes could be accounted for by maturation in the central auditory system of these patients. DESIGN: Study participants included 5 children (S1 to S5) with an ABI in the affected ear. The stimulus was a train of electrical pulses delivered to individual ABI electrodes via a research interface...
September 7, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28840850/classification-and-current-management-of-inner-ear-malformations
#16
Levent Sennaroğlu, Münir Demir Bajin
Morphologically congenital sensorineural hearing loss can be investigated under two categories. The majority of congenital hearing loss causes (80%) are membranous malformations. Here, the pathology involves inner ear hair cells. There is no gross bony abnormality and, therefore, in these cases high-resolution computerized tomography and magnetic resonance imaging of the temporal bone reveal normal findings. The remaining 20% have various malformations involving the bony labyrinth and, therefore, can be radiologically demonstrated by computerized tomography and magnetic resonance imaging...
September 29, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28837630/influence-of-electrode-array-stiffness-and-diameter-on-hearing-in-cochlear-implanted-guinea-pig
#17
Mylène Drouillard, Renato Torres, Elisabeth Mamelle, Daniele De Seta, Olivier Sterkers, Evelyne Ferrary, Yann Nguyen
During cochlear implantation, electrode array translocation and trauma should be avoided to preserve residual hearing. The aim of our study was to evaluate the effect of physical parameters of the array on residual hearing and cochlear structures during insertion. Three array prototypes with different stiffnesses or external diameters were implanted in normal hearing guinea pigs via a motorized insertion tool carried on a robot-based arm, and insertion forces were recorded. Array prototypes 0.4 and 0.4R had 0...
2017: PloS One
https://www.readbyqxmd.com/read/28769753/intraoperative-electrocochleographic-characteristics-of-auditory-neuropathy-spectrum-disorder-in-cochlear-implant-subjects
#18
William J Riggs, Joseph P Roche, Christopher K Giardina, Michael S Harris, Zachary J Bastian, Tatyana E Fontenot, Craig A Buchman, Kevin D Brown, Oliver F Adunka, Douglas C Fitzpatrick
Auditory neuropathy spectrum disorder (ANSD) is characterized by an apparent discrepancy between measures of cochlear and neural function based on auditory brainstem response (ABR) testing. Clinical indicators of ANSD are a present cochlear microphonic (CM) with small or absent wave V. Many identified ANSD patients have speech impairment severe enough that cochlear implantation (CI) is indicated. To better understand the cochleae identified with ANSD that lead to a CI, we performed intraoperative round window electrocochleography (ECochG) to tone bursts in children (n = 167) and adults (n = 163)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28766844/timing-of-cochlear-implantation-in-auditory-neuropathy-patients-with-otof-mutations-our-experience-with-10-patients
#19
C C Wu, C J Hsu, F L Huang, Y H Lin, Y H Lin, T C Liu, C M Wu
No abstract text is available yet for this article.
August 2, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28708635/the-management-of-pediatric-hearing-loss-caused-by-auditory-neuropathy-spectrum-disorder
#20
Nguyen S Pham
PURPOSE OF REVIEW: Auditory neuropathy spectrum disorder (ANSD) is a condition in which auditory testing reveals normal otoacoustic emissions, but auditory brainstem testing is abnormal or absent and speech discrimination is poor. This constellation of findings ostensibly suggests that the cochlea is healthy and an abnormality of conduction or processing of sound occurs along the nerve fibers. As more is learned about this condition, it is becoming clear that ANSD describes heterogeneous, distinct clinical entities that must be taken into account when devising treatment modalities...
July 13, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
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