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https://www.readbyqxmd.com/read/28633088/second-line-with-oxaliplatin-or-irinotecan-based-chemotherapy-for-gemcitabine-pretreated-pancreatic-cancer-a-systematic-review
#1
REVIEW
Fausto Petrelli, Alessandro Inno, Antonio Ghidini, Lorenza Rimassa, Gianluca Tomasello, Roberto Labianca, Sandro Barni
BACKGROUND: oxaliplatin (OXA)- and irinotecan (IRI)-based chemotherapies are the most frequently used salvage regimens in patients with metastatic pancreatic cancer (PC) after first-line gemcitabine-based therapy. There are no prospective comparisons of these regimens in this setting. We conducted a systematic review of published trials to compare the efficacy of these treatments. METHODS: studies that enrolled patients with stage IV disease receiving chemotherapy with OXA or IRI plus fluoropyrimidines were identified using electronic databases (Pubmed, Embase, SCOPUS, CINAHL, Web of Science and Cochrane Library)...
June 17, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28631980/orexin-research-patent-news-from-2016
#2
Christoph Boss, Catherine Roch
The orexin (hypocretin) system consists of two G-protein-coupled receptors, orexin 1 (Ox1) and orexin 2 (Ox2) and two endogenous peptidic ligands, orexin A (OxA) and orexin B (OxB). It is evolutionarily highly conserved. In the brain, it is involved in the promotion of wakefulness under motivational circumstances as well as in anxiety and addictive disorders. In addition, its activation via the Ox1 receptor triggers apoptosis in several cancer cell lines. Dual orexin receptor antagonists (DORAs) such as suvorexant are successfully used to treat primary insomnia...
June 20, 2017: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/28630202/identifying-spectra-of-activity-and-therapeutic-niches-for-ceftazidime-avibactam-and-imipenem-relebactam-against-carbapenem-resistant-enterobacteriaceae
#3
Ghady Haidar, Cornelius J Clancy, Liang Chen, Palash Samanta, Ryan K Shields, Barry N Kreiswirth, M Hong Nguyen
We determined imipenem, imipenem-relebactam, ceftazidime and ceftazidime-avibactam minimum inhibitory concentrations (MICs) against 100 CRE isolates that underwent whole genome sequencing. KPCs were the most common carbapenemases. Forty-six isolates carried ESBLs. With the addition of relebactam, imipenem susceptibility increased from 8% to 88%. With the addition of avibactam, ceftazidime susceptibility increased from 0% to 85%. Neither imipenem-relebactam nor ceftazidime-avibactam was active against MBL-producers...
June 19, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28626457/characterization-of-novel-integrons-in1085-and-in1086-and-the-surrounding-genes-in-plasmids-from-enterobacteriaceae-and-the-role-for-attcaada16-structural-features-during-atti1-%C3%A3-attc-integration
#4
Dongguo Wang, Wei Hou, Jiayu Chen, Linjun Yang, Zhihui Liu, Zhe Yin, Jiao Feng, Dongsheng Zhou
Novel class 1 integrons In1085 and In1086, containing the class D β-lactamase -encoding gene blaOXA, were identified in clinical enterobacterial strains. In this study, we aimed to characterize the genetic contexts of In1085 and In1086, with the goal of identifying putative mechanisms of integron mobilization. Four plasmids, approximately 5.3, 5.3, 5.7, and 6.6 kb, from 71 clinical Enterobacteriaceae strains were found to contain class 1 integrons (In37, In62, In1085, and In1086, respectively). Two of these plasmids, pEco336 and pNsa292, containing In1085 and In1086, respectively, were further characterized by antibiotic susceptibility testing, conjugation experiments, PCR, sequencing, and gene mapping...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28621934/tqopen-n-n-n-n-tetrakis-2-quinolylmethyl-3-oxa-1-5-pentanediamine-family-as-heptadentate-fluorescent-cd-2-sensors
#5
Yuji Mikata, Asako Kizu, Kana Nozaki, Hideo Konno, Hiroshi Ono, Shunsuke Mizutani, Shin-Ichiro Sato
A quinoline-based heptadentate ligand, N,N,N',N'-tetrakis(2-quinolylmethyl)-3-oxa-1,5-pentanediamine (TQOPEN), exhibits a fluorescence increase (ICd/I0 = 25, ϕCd = 0.017) at 428 nm upon addition of 1 equiv of Cd(2+). In contrast, 1 equiv of Zn(2+) induces a negligible fluorescence change due to weak interaction (IZn/I0 = 2.5, IZn/ICd = 10%). In comparison with TQOPEN, the thia and aza derivatives TQSPEN and TQNPEN exhibit improved Cd(2+)/Zn(2+) selectivity and higher Cd(2+)-binding affinity, respectively. The solid-state structures of mononuclear Cd(2+) and hydroxide-bridged dinuclear Zn(2+) complexes of TQOPEN were elucidated by X-ray crystallography...
June 16, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28621466/integrative-pericyclic-cascade-an-atom-economy-multi-c-c-bond-forming-strategy-for-the-construction-of-molecular-complexity
#6
Fernando García-Tellado, David Tejedor, Samuel Delgado-Hernández, Jesús Peyrac, Javier González-Platas
An all-pericyclic manifold is developed for the construction of topologically diverse, structurally complex and natural product-like polycyclic chemotypes. The manifold uses readily accessible tertiary propargyl vinyl ethers as substrates and an imidazole as a catalyst to form up to 2 new rings, 3 new C-C bonds, 6 stereogenic centers and one transannular oxo-bridge. The manifold is efficient, scalable and instrumentally simple to perform and entails a Propargyl Claisen rearrangement-[1,3]H-shift, an oxa-6 electrocyclization and an intramolecular Diels-Alder reaction...
June 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28614760/abundance-of-carbapenemase-genes-blakpc-blandm-and-blaoxa-48-in-wastewater-effluents-from-tunisian-hospitals
#7
Emna Nasri, Jessica Subirats, Alexandre Sànchez-Melsió, Hedi Ben Mansour, Carles M Borrego, José Luis Balcázar
Carbapenems are β-lactam antibiotics with a broad spectrum of activity and are usually considered the last resort for the treatment of severe infections caused by multidrug-resistant pathogens. The clinically most significant carbapenemases are KPC, NDM, and OXA-48-like enzymes, whose genes have been increasingly reported worldwide in members of the family Enterobacteriaceae. In this study, we quantified the abundance of these genes in wastewater effluents from different Tunisian hospitals. The blaNDM and blaOXA-48-like genes were detected at similar concentrations in all hospital wastewater effluents...
June 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28613899/biomimetic-total-synthesis-of-angiopterlactone-b-and-other-potential-natural-products
#8
Tharun K Kotammagari, Rajesh G Gonnade, Asish K Bhattacharya
A one-pot biomimetic synthesis of (-)-angiopterlactone B and its enantiomer (+)-angiopterlactone B has been accomplished via TBAF-catalyzed tandem ring contraction followed by oxa-Michael/Michael addition sequence. Comparison of specific optical rotations, absolute configurations, and CD spectra of natural, synthesized (-)-angiopterlactone B and (+)-angiopterlactone B unequivocally proves that the isolated angiopterlactone B must be levorotatory. Synthesis of hitherto undiscovered natural products 18 and 20 and analogues of angiopterlactone B demonstrate the versatility of this method...
June 14, 2017: Organic Letters
https://www.readbyqxmd.com/read/28611664/2-pentadecyl-2-oxazoline-the-oxazoline-of-pea-modulates-carrageenan-induced-acute-inflammation
#9
Stefania Petrosino, Michela Campolo, Daniela Impellizzeri, Irene Paterniti, Marco Allarà, Enrico Gugliandolo, Ramona D'Amico, Rosalba Siracusa, Marika Cordaro, Emanuela Esposito, Vincenzo Di Marzo, Salvatore Cuzzocrea
N-acylethanolamines (NAEs) involve a family of lipid molecules existent in animal and plant, with N-palmitoylethanolamide (PEA) that arouses great attention owing to its anti-inflammatory, analgesic and neuroprotective activities. Because PEA is produced on demand and exerts pleiotropic effects, the modulation of specific amidases for NAEs (and in particular NAE-hydrolyzing acid amidase NAAA, which is more selective for PEA) could be a condition to preserve its levels. Here we investigate the effect of 2-Pentadecyl-2-oxazoline (PEA-OXA) the oxazoline of PEA, on human recombinant NAAA in vitro and in an established model of Carrageenan (CAR)-induced rat paw inflammation...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28610832/comparison-of-antimicrobial-activity-between-ceftolozane-tazobactam-and-ceftazidime-avibactam-against-multidrug-resistant-isolates-of-escherichia-coli-klebsiella-pneumoniae-and-pseudomonas-aeruginosa
#10
Adnan Alatoom, Hashim Elsayed, Karen Lawlor, Laila AbdelWareth, Rania El-Lababidi, Lysettee Cardona, Mohammad Mooty, Maria-Fernanda Bonilla, Ahmad Nusair, Imran Mirza
OBJECTIVE: We compared the activity of ceftolozane-tazobactam and ceftazidime-avibactam against 120 strains including extended spectrum β-lactamase (ESBL) producers, carbapenem-resistant Enterobacteriaceae (CRE) and Pseudomonas aeruginosa isolated from patients admitted to Cleveland Clinic Abu Dhabi, United Arab Emirates. METHODS: The in-vitro susceptibility was tested using E-strip MIC method and PCR was used to characterize the carbapenemase enzymes produced by CRE strains...
June 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28607010/comparison-of-two-phenotypic-algorithms-to-detect-carbapenemase-producing-enterobacteriaceae
#11
Laurent Dortet, Sandrine Bernabeu, Camille Gonzalez, Thierry Naas
A novel algorithm designed for the screening of carbapenemase producing Enterobactericeae (CPE), based on faropenem and temocillin disks was compared to that of the French Society of Microbiology (CA-SFM), which is based on ticarcillin-clavulanate, imipenem and temocillin disks. Both algorithms presented comparable negative predictive values (98.6% vs 97.5%) for the CPE screening among carbapenem non-susceptible Enterobacteriaceae However, since 46.2% (n=49) of the CPEs were correctly identified as OXA-48-like producers by the faropenem/temocillin-based algorithm, it significantly decreased the number of complementary tests needed (42...
June 12, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28604100/molecular-epidemiology-of-carbapenem-resistant-acinetobacter-baumannii-in-greece-an-extended-review-2000-2015
#12
Theodoros Karampatakis, Charalampos Antachopoulos, Athanassios Tsakris, Emmanuel Roilides
Carbapenem-resistant Acinetobacter baumannii (CRAB) is endemic in Greece. CRAB initially emerged in 2000 and since then, carbapenemases still have a crucial role in CRAB appearance, except for a few cases resulting from efflux pump or outer-membrane protein mechanisms. OXA-type carbapenemases present the highest prevalence worldwide and bla OXA-23-like and bla OXA-58-like are the most important genes found; VIM-yielding CRAB have also been detected, while a single CRAB isolate producing NDM has quite recently emerged in Greece...
June 12, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28604000/total-syntheses-of-%C3%A2-rhodonoids-c-d-e-f-and-g-and-ranhuadujuanine-b
#13
Hao Wu, Richard P Hsung, Yu Tang
Here we describe the divergent, biosynthetically inspired syntheses of (±)-rhodonoids C-G and (±)-ranhuadujuanine B. The key steps of the syntheses include the construction of the chromene unit through a formal oxa-[3 + 3] annulation and a biomimetic acid-catalyzed ring cyclization. Cationic [2 + 2] cycloaddition is accomplished to form the cyclobutane core of (±)-rhodonoids E and F.
June 12, 2017: Organic Letters
https://www.readbyqxmd.com/read/28599158/degradation-of-highly-consumed-fluoroquinolones-penicillins-and-cephalosporins-in-distilled-water-and-simulated-hospital-wastewater-by-uv254-and-uv254-persulfate-processes
#14
Efraím A Serna-Galvis, Franklin Ferraro, Javier Silva-Agredo, Ricardo A Torres-Palma
In this work, three penicillins (ampicillin "AMP", oxacillin "OXA" and cloxacillin "CLO"), two cephalosporins (cephalexin "CPX" and cephadroxyl "CPD") and three fluoroquinolones (levofloxacin "LEV", norfloxacin "NOR" and ciprofloxacin "CIP") were initially treated by UV254 and persulfate activated by UV254 (UV/PS). Significant differences in degradation kinetics under UV254 irradiation were found. Photodegradation followed the order: OXA > CPX > CPD > CLO > CIP > NOR > AMP ≫ LEV...
June 1, 2017: Water Research
https://www.readbyqxmd.com/read/28597659/vibrational-spectroscopy-and-proton-transfer-dynamics-in-protonated-oxalate
#15
Zhen-Hao Xu, Markus Meuwly
The dynamics and infrared spectroscopic signatures of proton transfer in protonated oxalate (p-Oxa) are studied using classical and quantum dynamics. The intermolecular interactions are described by a force field suitable to follow proton transfer. This allows to carry out multiple extended classical molecular dynamics (MD) and ring polymer MD simulations from which the infrared spectrum is determined. Simulations at 600 K sample the quantum mechanical ground state probability distribution and best reproduce the experimentally observed maximum absorption wavelength and part of the line shape...
June 9, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28585170/rapid-and-simple-identification-of-carbapenemase-genes-bla-ndm-bla-oxa-48-bla-vim-bla-imp-14-and-bla-kpc-groups-in-gram-negative-bacilli-by-in-house-loop-mediated-isothermal-amplification-with-hydroxynaphthol-blue-dye
#16
Arpasiri Srisrattakarn, Aroonlug Lulitanond, Chotechana Wilailuckana, Nicha Charoensri, Lumyai Wonglakorn, Pimjai Saenjamla, Prajuab Chaimanee, Jureerut Daduang, Aroonwadee Chanawong
Carbapenem-resistant Enterobacteriaceae isolates by carbapenemase production are being reported globally with increasing frequency, leading to limited therapeutic options. We therefore developed a loop-mediated isothermal amplification method with hydroxynaphthol blue dye (LAMP-HNB) for rapid confirmation of bla NDM, bla OXA-48, bla VIM, bla IMP-14 and bla KPC groups. Sixty-two Enterobacteriaceae and Pseudomonas spp. isolates carrying various carbapenemase genes (28 bla NDM-1, 9 bla IMP-14a, 2 bla IMP-48, 1 bla IMP-1, 1 bla IMP-4, 1 bla IMP-9, 1 bla IMP-15, 4 bla VIM-2, 1 bla VIM-1, 1 bla IMP-14a & bla VIM-2, 7 bla KPC-2, 3 bla OXA-48 and 3 bla OXA-181) and 37 non-carbapenemase-producing Enterobacteriaceae isolates as confirmed by the PCR methods were included...
July 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28583370/prostaglandin-e2-stimulates-adaptive-il-22-production-and-promotes-allergic-contact-dermatitis
#17
Calum T Robb, Henry J McSorley, Jinju Lee, Tomohiro Aoki, Cunjing Yu, Siobhan Crittenden, Anne Astier, Jennifer M Felton, Nicholas Parkinson, Adane Ayele, Richard M Breyer, Stephen M Anderton, Shuh Narumiya, Adriano G Rossi, Sarah E Howie, Emma Guttman-Yassky, Richard B Weller, Chengcan Yao
BACKGROUND: Atopic dermatitis (AD) and allergic contact dermatitis (ACD) are both forms of eczema and are common inflammatory skin diseases with a central role of Th22-derived IL-22 in their pathogenesis. Although prostaglandin E2 (PGE2) is known to promote inflammation, little is known about its role in processes related to AD and ACD development, including IL-22 up-regulation. OBJECTIVES: To investigate whether PGE2 has a role in IL-22 induction and development of ACD, which has increased prevalence in patients with AD...
June 2, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28581743/tethered-1-2-si-group-migrations-in-radical-mediated-ring-enlargements-of-cyclic-alkoxysilanes-an-epr-spectroscopic-and-computational-investigation
#18
John C Walton, Ryutaro Kanada, Takeaki Iwamoto, Satoshi Shuto, Hiroshi Abe
5- t0 6-Member ring enlargements of 3-oxa-2-silacyclopentylmethyl to 4-oxa-3-silacyclohexyl radicals were investigated by EPR spectroscopy and QM computations of model indano-oxasilacyclopentane and oxasilinanyl compounds. Both experimental and computational evidence favored a mechanism via a concerted 1,2-migration of the "tethered" Si-group. Thus the "forbidden" 1,2-Si-group migration from carbon to carbon becomes allowed when the Si-group is "tethered." The EPR data from 3-oxa-2-silacyclopentylmethyl radicals disclosed ground state conformations having semi-occupied p-orbitals close to antiperiplanar with respect to their beta-Si-C bonds; but indicated Si-hyperconjugation (beta-silicon effect) was insignificant in radicals...
June 5, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28577870/mitochondria-as-the-target-for-the-modulatory-effect-of-curcumin-in-oxaliplatin-induced-toxicity-in-isolated-rat-liver-mitochondria
#19
Mohammad Waseem, Suhel Parvez, Heena Tabassum
BACKGROUND AND AIMS: To explore hepatoprotective action of curcumin (CMN, a bioflavonoid) on oxaliplatin (Oxa)-triggered mitochondrial oxidative stress and respiratory chain complexes in liver of rats. Oxa is a ubiquitously utilized platinum-based chemotherapeutic agent commonly used for the treatment of colorectal cancer. Mitochondria have recently emerged as targets for anticancer drugs in several kinds of toxicity including hepatotoxicity that can lead to neoplastic disease. There is a dearth of evidence involving the role of mitochondria in mediating Oxa-evoked hepatotoxicity and its underlying mechanism is still debatable...
January 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28577277/in-vitro-production-of-insulin-responsive-skeletal-muscle-tissue-from-mouse-embryonic-stem-cells-by-spermine-induced-differentiation-method
#20
Mikako Saito, Ayano Ishida, Shota Nakagawa
The treatment of an embryoid body with spermine for a short duration can trigger the generation of a 3-dimensional multilayer myotube sheet (MMTS) that shows pulsatile activity. MMTS was previously characterized as a model of skeletal muscle tissue. In the present work, the insulin responsiveness of MMTS was investigated because it is an essential function for a model of skeletal muscle. The glucose uptake activity of MMTS was analyzed by confocal microscopy using fluorescent glucose analogs, namely 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose (2-NBDG) and its L-glucose counterpart, 2-NBDLG...
June 2, 2017: Human Cell
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