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https://www.readbyqxmd.com/read/28104439/up-regulation-of-cyp1a1-and-phase-ii-enzymes-by-5-ring-isomeric-polycyclic-aromatic-hydrocarbons-in-precision-cut-rat-hepatic-slices-importance-of-molecular-shape
#1
Daphnee Pushparajah, Dfv Lewis, Costas Ioannides
The objectives of the present study were two-fold: (a) to evaluate the role of molecular shape on the interaction of polycyclic aromatic hydrocarbons (PAHs) with the Ah receptor and CYP1A1 upregulation, and (b) to evaluate the potential of PAHs to induce epoxide hydrolase and glutathione S-transferase, two major enzymes in their metabolism. In order to achieve these objectives, precision-cut rat liver slices were incubated with a range of concentrations of seven 5-ring isomeric PAHs, namely benzo[c]chrysene, benzo[b]chrysene, benzo[g]chrysene, dibenzo[a,j]anthracene, dibenzo[a,c]anthracene, picene and pentacene, for 24h...
January 16, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28099062/rectal-carriage-of-extended-spectrum-beta-lactamase-and-carbapenemase-producing-gram-negative-bacilli-in-intensive-care-units-in-tunisia
#2
Samia Hammami, Chaima Dahdeh, Kelthoum Mamlouk, Sana Ferjeni, Elaa Maamar, Zeineb Hamzaoui, Mabrouka Saidani, Salma Ghedira, Mohamed Houissa, Amin Slim, Ilhem Boutiba-Ben Boubaker
This study was conducted to evaluate the rate of fecal carriage of Gram-negative bacilli (GNB) resistant to third-generation cephalosporins (third GC) in patients hospitalized in the intensive care unit (ICU) of Charles Nicolle Hospital of Tunis and to identify the enzymatic mechanisms involved. From February to April 2014, rectal swabs were collected from all patients (n = 38) at admission and once weekly thereafter to identify acquisition. They were cultured on desoxycholate-lactose-agar plates supplemented with cefotaxime (2 mg/L)...
January 18, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28095794/development-of-an-algorithm-for-phenotypic-screening-of-carbapenemase-producing-enterobacteriaceae-in-the-routine-laboratory
#3
Jérôme Robert, Alix Pantel, Audrey Merens, Elodie Meiller, Jean-Philippe Lavigne, Marie-Hélène Nicolas-Chanoine
BACKGROUND: Carbapenemase-producing Enterobacteriaceae (CPE) are difficult to identify among carbapenem non-susceptible Enterobacteriaceae (NSE). We designed phenotypic strategies giving priority to high sensitivity for screening putative CPE before further testing. METHODS: Presence of carbapenemase-encoding genes in ertapenem NSE (MIC > 0.5 mg/l) consecutively isolated in 80 French laboratories between November 2011 and April 2012 was determined by the Check-MDR-CT103 array method...
January 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28095731/n-palmitoylethanolamine-oxazoline-pea-oxa-as-a-new-therapeutic-strategy-to-control-neuroinflammation-neuroprotective-effects-in-experimental-models-of-spinal-cord-and-brain-injury
#4
Daniela Impellizzeri, Marika Cordaro, Giuseppe Bruschetta, Rosalba Siracusa, Rosalia Crupi, Emanuela Esposito, Salvatore Cuzzocrea
Modulation of N-acylethanolamine-hydrolyzing acid amidase (NAAA) represents a potential alternative strategy in the treatment of neuroinflammation. Recent studies showed that pharmacological modulation of NAAA could be achieved with the oxazoline of palmitoylethanolamide (PEA) (PEA-OXA). The aim of this study was to evaluate the neuroprotective effects of PEA-OXA in the secondary neuro-inflammatory events induced by spinal and brain trauma in mice. Animals were subjected to spinal cord and brain injury models and PEA-OXA (10 mg/kg) administered both intraperitoneally and orally 1 h and 6 h after trauma...
January 17, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28090775/reaction-of-push-pull-enaminoketones-and-in-situ-generated-ortho-quinone-methides-synthesis-of-3-acyl-4h-chromenes-and-2-acyl-1h-benzo-f-chromenes-as-precursors-for-hydroxybenzylated-heterocycles
#5
Anton Vladimirovich Lukashenko, Vitaly Aleksandrovich Osyanin, Dmitry Vladimirovich Osipov, Yuri N Klimochkin
A simple and efficient method for the synthesis of 4H-chromenes and 1H-benzo[f]chromenes containing trifluoroacetyl or aroyl group in pyran ring from o-quinone methide precursors and push-pull enaminoketones has been developed. The chromenes are presumably formed through an initial oxa-Diels-Alder reaction followed by an elimination of amine. Possibility of further transformations of given chromenes to o-hydroxybenzylated pyrazoles, isoxazoles and pyridines has been demonstrated.
January 16, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28089263/adiponectin-orexin-a-and-orexin-b-concentrations-in-the-serum-and-uterine-luminal-fluid-during-early-pregnancy-of-pigs
#6
Nina Smolinska, Marta Kiezun, Kamil Dobrzyn, Karol Szeszko, Anna Maleszka, Tadeusz Kaminski
Adiponectin is the most abundant adipose-released protein that circulates in human plasma at high concentrations. The neuropeptides orexin A (OXA, hypocretin-1) and orexin B (OXB, hypocretin-2) are derived from a common precursor peptide, prepro-orexin and are produced mainly by neurons located in the lateral hypothalamus. It has been demonstrated that the peptides such as adiponectin and orexins have an important role in the regulation of energy metabolism and neuroendocrine functions. These hormones appear to be implicated in both normal and disturbed pregnancy...
January 9, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28081345/growing-oxa-23-type-strains-among-carbapenem-resistant-acinetobacter-baumannii-and-tigecycline-as-an-alternate-combination-therapy
#7
Şerife Altun, Zeliha Koçak Tufan, Belgin Altun, Ufuk Önde, Sami Kınıklı, Ali Pekcan Demiröz
BACKGROUND/AIM: The increasing prevalence and global spread of difficult-to-treat carbapenem-resistant Acinetobacter baumannii has become a serious problem. The aim of this study is to investigate the resistance patterns and tigecycline sensitivity of carbapenem-resistant A. baumannii strains. MATERIALS AND METHODS: Acinetobacter strains that were carbapenem-resistant and collected mainly from intensive care units were included into this study. The antibiotic sensitivity/resistance of the strains to other antibiotics and tigecycline were noted...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28080212/heterogeneity-of-carbapenem-resistance-mechanisms-among-gram-negative-pathogens-in-lebanon-results-of-the-first-cross-sectional-countrywide-study
#8
Dalal Hammoudi Halat, Carole Ayoub Moubareck, Dolla Karam Sarkis
Carbapenem-resistant Gram-negative pathogens have progressively disseminated to different countries worldwide, presenting a serious public health concern. The aims of this study were to determine the prevalence of carbapenem resistance in Gram-negative bacteria in Lebanon, to elucidate molecular mechanisms, and to identify genetic relatedness of incriminated strains. Carbapenem nonsusceptible Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas were collected from 11 Lebanese hospitals in 2012. Antimicrobial susceptibility was assessed with phenotypic tests, genes encoding carbapenemases were screened via PCR-sequencing, and genetic relatedness was examined by PGFE and ERIC-PCR...
January 12, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28080074/synthesis-of-briarane-diterpenoids-biomimetic-transannular-oxa-6%C3%AF-electrocyclization-induced-by-a-uva-uvc-photoswitch
#9
Andrew J Hall, Stéphane P Roche, Lyndon M West
A biomimetic synthesis of briareolate ester B (3) from briareolate ester L (1) via the intermediate briareolate ester G (2) has been achieved through a unique transannular oxa-6π electrocyclization induced by UVA light. UVC irradiation of 3 triggered a rapid retro-6π electrocyclization to establish an unprecedented photochromic switch. In the ground state, reaction of 1 led to the formation of a polycyclic γ-spiroketal γ-lactone 5, architecturally related to the ether-bridged cembranoids of the cladiellin class...
January 12, 2017: Organic Letters
https://www.readbyqxmd.com/read/28061506/role-of-rem-sleep-melanin-concentrating-hormone-and-orexin-hypocretin-systems-in-the-sleep-deprivation-pre-ischemia
#10
Marta Pace, Antoine Adamantidis, Laura Facchin, Claudio Bassetti
STUDY OBJECTIVES: Sleep reduction after stroke is linked to poor recovery in patients. Conversely, a neuroprotective effect is observed in animals subjected to acute sleep deprivation (SD) before ischemia. This neuroprotection is associated with an increase of the sleep, melanin concentrating hormone (MCH) and orexin/hypocretin (OX) systems. This study aims to 1) assess the relationship between sleep and recovery; 2) test the association between MCH and OX systems with the pathological mechanisms of stroke...
2017: PloS One
https://www.readbyqxmd.com/read/28056839/molecular-epidemiology-of-bla-oxa-23-producing-carbapenem-resistant-acinetobacter-baumannii-in-a-single-institution-over-a-65-month-period-in-north-china
#11
Nian-Zhi Ning, Xiong Liu, Chun-Mei Bao, Su-Ming Chen, En-Bo Cui, Ju-Ling Zhang, Jie Huang, Fang-Hong Chen, Tao Li, Fen Qu, Hui Wang
BACKGROUND: Carbapenem-resistant Acinetobacter baumannii poses a significant threat to hospitalized patients, as few therapeutic options remain. Thus, we investigated the molecular epidemiology and mechanism of resistance of carbapenem-resistant A.baumannii isolates in Beijing, China. METHODS: Carbapenem-resistant A.baumannii isolates (n = 101) obtained between June 2009 and November 2014 were used. Multilocus sequence typing (MLST) and PCR assays for class C and D β-lactamase were performed on all isolates...
January 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28042031/chemoimmunotherapy-by-combining-oxaliplatin-with-immune-checkpoint-blockades-reduced-tumor-burden-in-colorectal-cancer-animal-model
#12
Weiwei Wang, Ling Wu, Jiansheng Zhang, Huiguo Wu, Enkun Han, Qiang Guo
BACKGROUND: Colorectal cancer (CRC) is among one of the top common cancers worldwide. Developing novel comprehensive treatment strategies is critical for improving survival of late stage CRC patients. Recent advances in immune checkpoint blockades provided a novel strategy for treating cancers via stimulating the antitumor immune response. However, the effects of immune checkpoint blockades were limited in CRC due to intrinsic resistance. Oxaliplatin (OXA) based chemotherapy was the foundation of CRC adjuvant chemotherapy...
December 29, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28039279/oxa-48-producing-st372-escherichia-coli-in-a-french-dog
#13
Luana C Melo, Marine N G Boisson, Estelle Saras, Christine Médaille, Henri-Jean Boulouis, Jean-Yves Madec, Marisa Haenni
No abstract text is available yet for this article.
December 30, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28035913/microrna-137-chemosensitizes-colon-cancer-cells-to-the-chemotherapeutic-drug-oxaliplatin-oxa-by-targeting-ybx1
#14
Yunsheng Guo, Yan Pang, Xia Gao, Min Zhao, Xin Zhang, Hao Zhang, Bing Xuan, Yimin Wang
The mechanisms underlying oxaliplatin (OXA) resistance in colon cancer cells are not fully understood. MicroRNAs (miRNAs) play important roles in tumorigenesis and drug resistance. However, the relationship between miRNA and OXA resistance in colon cancer cells has not been previously explored. In this study, we utilized microRNA microarray analysis and real-time PCR to verify that miR-93, miR-191, miR-137, miR-181 and miR-491-3p were significantly down-regulated and that miR-96, miR-21, miR-22, miR-15b and miR-92 were up-regulated in both HCT-15/OXA and SW480/OXA cell lines...
December 23, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28034597/draft-genome-sequence-of-a-multidrug-resistant-beta-lactamase-oxa-357-producing-acinetobacter-pittii-st865-clinical-isolate-from-china
#15
Jianfeng Wang, Yan Chen, Liyan Wu, Yu Chen, Liqun Xu
Worldwide increasing emergence of carbapenem-resistant Acinetobacter spp. has rendered the limited availability of effective antimicrobial agents and has become a major public health concern. In this study, we report the draft genome sequence of A. pittii TCM156, a multidrug-resistant isolate that harbored the blaOXA-357 gene. The genome sequence was further analyzed by various bioinformatics methods. The genome size was estimated to be 3,807,313bp with 3508 predicted coding regions and G+C content is 38.7%...
December 14, 2016: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28034311/total-syntheses-of-%C3%A2-rhodonoids-a-and-b-and-c12-epi-rhodonoid-b
#16
Hao Wu, Richard P Hsung, Yu Tang
Total syntheses of (±)-rhodonoids A and B and C12-epi-rhodonoid B are described here. A unified strategy employed in these syntheses is an intramolecular oxa-[3 + 3] annulation for accessing the chromene unit. A Fe(OTf)3-promoted diastereoselective cationic [2 + 2] cycloaddition and a photochemical [2 + 2] cycloaddition were featured to construct the cyclobutane core of (±)-rhodonoids A and B and C12-epi-rhodonoid B, respectively. Fe(OTf)3 also leads to an interesting bridged tetracycle, which was unambiguously confirmed by single crystal X-ray analysis...
January 17, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28032978/exploring-the-structural-compliancy-versus-specificity-of-the-estrogen-receptor-using-isomeric-three-dimensional-ligands
#17
Naina Sharma, Kathryn E Carlson, Jerome C Nwachukwu, Sathish Srinivasan, Abhishek Sharma, Kendall W Nettles, John A Katzenellenbogen
The estrogen receptors (ERs) bind with high affinity to many structurally diverse ligands by significantly distorting the contours of their ligand-binding pockets. This raises a question: To what degree is ER able to distinguish between structurally related regioisomers and enantiomers? We have explored the structural compliance and specificity of ERα with a set of ligands having a 7-oxa-bicyclo[2.2.1]hept-5-ene sulfonate core and basic side chains typical of selective ER modulators (SERMs). These ligands have two regioisomers, each of which is a racemate of enantiomers...
December 29, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/28031433/comparison-of-phenotypic-tests-and-an-immunochromatographic-assay-and-development-of-a-new-algorithm-for-oxa-48-like-detection
#18
Florian Koroska, Stephan Göttig, Martin Kaase, Jörg Steinmann, Sören Gatermann, Julian Sommer, Thorsten Wille, Georg Plum, Axel Hamprecht
OXA-48 is the most prevalent carbapenemase in Enterobacteriaceae in Europe and the Middle East, but is frequently missed because many isolates display low minimal inhibitory concentrations (MIC) for carbapenems. Furthermore, in contrast to metallo-β-lactamases or Klebsiella pneumoniae carbapenemases (KPC), no specific inhibitor is available for the phenotypic detection of OXA-48. Molecular detection of blaOXA-48 is the gold standard, but is not available in many laboratories. Few phenotypic assays have been described, but have not been independently evaluated...
December 28, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28029250/frutescone-a%C3%A2-g-tasmanone-based-meroterpenoids-from-the-aerial-parts-of-baeckea-frutescens
#19
Ji-Qin Hou, Cui Guo, Jian-Juan Zhao, Qi-Wei He, Bao-Bao Zhang, Hao Wang
Frutescone A‒G [(1‒6), (+)-7, (‒)-7], a new group of naturally occurring tasmanone-based meroterpenoids, were isolated from the aerial part of Baeckea frutescens L. Compounds 1 and 4 featured a rare carbon skeleton with an unprecedented oxa-spiro[5.8] tetradecadiene ring system, existing as two favoured equilibrating conformers in CDCl3 solution, identified by variable-temperature NMR. The regioselective syntheses of 4‒7 were achieved in a concise manner by a biomimetically inspired key Hetero-Diels-Alder reaction "on water"...
December 28, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28013264/comparing-the-outcomes-of-patients-with-carbapenemase-producing-and-non-carbapenemase-producing-carbapenem-resistant-enterobacteriaceae-bacteremia
#20
Pranita D Tamma, Katherine E Goodman, Anthony D Harris, Tsigereda Tekle, Ava Roberts, Abimbola Taiwo, Patricia J Simner
BACKGROUND: Carbapenem-resistant Enterobacteriaceae (CRE) are associated with considerable mortality. As mechanisms of carbapenem resistance are heterogeneous, it is unclear if mortality differs based on resistance mechanisms. We sought to determine whether CRE resistance mechanism determination is prognostically informative. METHODS: We conducted an observational study comparing 14-day mortality between patients with carbapenemase-producing (CP)-CRE compared with non-CP-CRE bacteremia...
February 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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