Zoe K McQuilten, Robert Weinkove, Le Thi Phuong Thao, Philip Crispin, Amber Degelia, Claire Dendle, Michael Gilbertson, Anna Johnston, Anastazia Keegan, Dominic Pepperell, Humphrey Pullon, John Reynolds, Tina van Tonder, Judith Trotman, Neil Waters, Cameron Wellard, Helen Weston, C Orla Morrissey, Erica M Wood
Immunoglobulin replacement and prophylactic antibiotics are commonly used to prevent infections in patients with secondary hypogammaglobulinemia due to hematological malignancies but have never been directly compared. In this randomized controlled feasibility trial conducted in 7 hospitals in Australia and New Zealand, we enrolled patients with secondary hypogammaglobulinemia with either a history of recurrent/severe infection or an immunoglobulin G level <4 g/L. Participants were randomized in a 1:2 ratio to immunoglobulin (0...
April 9, 2024: Blood Advances