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https://www.readbyqxmd.com/read/28818290/hepatic-resection-a-safe-and-effective-surgery
#1
David Calatayud, Santiago Sánchez Cabús, Jaime Sampson, Aridai Resendiz, Victor Molina, Constantino Fondevila, Josep Fuster, Juan Carlos García-Valdecasas
INTRODUCTION: We analyze major liver resections performed in 10 years, with the objective of evaluating perioperative results. As secondary objectives, factors related to major complications and comparative analyses of 25-year periods are evaluated. METHODS: Retrospective analysis of patients undergoing major hepatic resection (3 or more segments) from January 2005 to December 2014, from pre, intra and postoperative data. The Clavien classification is used for postoperative morbidity...
August 14, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28814616/the-yale-observation-scale-score-and-the-risk-of-serious-bacterial-infections-in-febrile-infants
#2
Lise E Nigrovic, Prashant V Mahajan, Stephen M Blumberg, Lorin R Browne, James G Linakis, Richard M Ruddy, Jonathan E Bennett, Alexander J Rogers, Leah Tzimenatos, Elizabeth C Powell, Elizabeth R Alpern, T Charles Casper, Octavio Ramilo, Nathan Kuppermann
OBJECTIVES: To assess the performance of the Yale Observation Scale (YOS) score and unstructured clinician suspicion to identify febrile infants ≤60 days of age with and without serious bacterial infections (SBIs). METHODS: We performed a planned secondary analysis of a prospective cohort of non-critically ill, febrile, full-term infants ≤60 days of age presenting to 1 of 26 participating emergency departments in the Pediatric Emergency Care Applied Research Network...
June 6, 2017: Pediatrics
https://www.readbyqxmd.com/read/28807085/variation-in-bacterial-endosymbionts-associated-with-the-date-palm-hopper-ommatissus-lybicus-populations
#3
S Karimi, H Izadi, M Askari Seyahooei, A N Bagheri, P Khodaygan
The date palm hopper, Ommatissus lybicus, is a key pest of the date palm, which is expected to be comprised of many allopatric populations. The current study was carried out to determine bacterial endosymbiont diversity in the different populations of this pest. Ten date palm hopper populations were collected from the main date palm growing regions in Iran and an additional four samples from Pakistan, Oman, Egypt and Tunisia for detection of primary and secondary endosymbionts using polymerase chain reaction (PCR) assay with their specific primers...
August 15, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28806468/an-overview-of-hemophagocytic-lymphohistiocytosis
#4
Ysabella M Esteban, Jill L O de Jong, Melissa S Tesher
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome characterized by a dysregulated hyperinflammatory response associated with aberrant activation of lymphocytes and macrophages that results in hypercytokinemia. It is classically divided into two types: (1) primary or familial HLH and (2) secondary HLH. Familial HLH is generally an autosomal recessive condition, whereas secondary HLH is usually associated with infectious diseases, autoinflammatory and autoimmune diseases (where it is more commonly known as macrophage activation syndrome), malignancy, immunosuppression, hematopoietic stem cell transplantation, organ transplantation, HIV infection, and metabolic diseases...
August 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28798159/as-cath1-6-novel-cathelicidins-with-potent-antimicrobial-and-immunomodulatory-properties-from-alligator-sinensis-play-pivotal-roles-in-host-antimicrobial-immune-responses
#5
Yan Chen, Shasha Cai, Xue Qiao, Mali Wu, Zhilai Guo, Renping Wang, Yi-Qun Kuang, Haining Yu, Yipeng Wang
Crocodilians are regarded as possessing a powerful immune system. However, the composition and action of the crocodilian immune system have remained unclear until now. Cathelicidins, the principal family of host defense peptides, play pivotal roles in vertebrate immune defense against microbial invasions. However, cathelicidins from crocodilians have not been extensively studied to date. In the present study, six novel cathelicidins (As-CATH1-6) were identified and characterized from the endangered Chinese alligator (Alligator sinensis)...
August 10, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28794881/procalcitonin-a-promising-diagnostic-marker-for-sepsis-and-antibiotic-therapy
#6
REVIEW
Ashitha L Vijayan, Vanimaya, Shilpa Ravindran, R Saikant, S Lakshmi, R Kartik, Manoj G
BACKGROUND: Sepsis is a global healthcare problem, characterized by whole body inflammation in response to microbial infection, which leads to organ dysfunction. It is becoming a frequent complication in hospitalized patients. Early and differential diagnosis of sepsis is needed critically to avoid unnecessary usage of antimicrobial agents and for proper antibiotic treatments through the screening of biomarkers that sustains with diagnostic significance. MAIN BODY OF ABSTRACT: Current targeting conventional markers (C-reactive protein, white blood cell, tumour necrosis factor-α, interleukins, etc...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28791178/kelp-and-dolphin-gulls-cause-perineal-wounds-in-south-american-fur-seal-pups-arctocephalus-australis-at-guafo-island-chilean-patagonia
#7
Mauricio Seguel, Francisco Muñoz, Felipe Montalva, Diego Perez-Venegas, Héctor Pavés, Nicole Gottdenker
During five reproductive seasons, we documented the presence, extent and origin of perineal wounds in South American fur seal pups (Arctocephalus australis) on Guafo Island, Northern Chilean Patagonia. The seasonal prevalence of perineal wounds ranged from 5 to 9%, and new cases were more common at the end of the breeding season (February), when pups were on average two months old and were actively expelling hookworms (Uncinaria sp). Histologically, wounds corresponded to marked ulcerative lymphoplasmacytic and histiocytic dermatitis with granulation tissue and mixed bacterial colonies...
July 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28783247/bacterial-translocation-and-clinical-progression-of-hcv-related-cirrhosis-in-hiv-infected-patients
#8
Nicolás Merchante, Teresa Aldámiz-Echevarría, Mónica García-Álvarez, Antonio Rivero-Juárez, Juan Macías, Pilar Miralles, María A Jiménez-Sousa, María Mancebo, Leire Pérez-Latorre, Daniel Pineda-Tenor, Juan Berenguer, Salvador Resino, Juan A Pineda
The aim of the study was to evaluate if bacterial translocation (BT) predicts the clinical outcome in HIV/HCV-coinfected patients with compensated cirrhosis. Acohort of 282 HIV/HCV-coinfected patients with cirrhosis and no previous liver decompensation (LD) was recuited. Serum levels of the DNA sequences encoding the well-conserved 16S rRNA subunit (16S rDNA), the lipopolysaccharide (LPS) and soluble CD14 (sCD14) at diagnosis of cirrhosis were measured. Primary end-point was the emergence of the first LD and/or death of any cause...
August 7, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28779997/the-bacterial-species-associated-with-aspirated-foreign-bodies-in-children
#9
Maayan Gruber, Graeme van Der Meer, Benjamin Ling, Colin Barber, Nikki Mills, Michel Neeff, Lesley Salkeld, Murali Mahadevan
OBJECTIVE: Inhaled foreign bodies in children are common and may be complicated by secondary airway tract infection. The inhaled foreign body may act as carrier of infectious material and the aim of this study was to explore the bacterial species associated with aspirated foreign bodies in a cohort of children. METHODS: Retrospective case series of 34 patients who underwent rigid laryngobronchoscopy because of foreign body aspiration. Each patient had a sample taken from tracheobronchial secretions during the procedure...
August 2, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28776100/dalbavancin-for-outpatient-parenteral-antimicrobial-therapy-of-skin-and-soft-tissue-infections-in-a%C3%A2-returning-traveller-proposal-for-novel-treatment-indications
#10
Johannes Mischlinger, Heimo Lagler, Nicole Harrison, Michael Ramharter
Skin and soft tissue infections (SSTIs) are among the most common health problems in travellers returning from tropical and subtropical countries. Importantly, the prevalence of Staphylococcus aureus, the most common pathogen for purulent SSTIs, with specific drug resistance, such as methicillin resistant Staphylococcus aureus (MRSA) and those expressing virulence genes, such as Panton-Valentine-leukocidin is higher in tropical regions than in most high resource settings. This poses challenges for the empirical antimicrobial treatment of SSTIs in returning travellers...
August 3, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28775098/influenza-virus-infection-alters-ion-channel-function-of-airway-and-alveolar-cells-mechanisms-and-physiological-sequelae
#11
James D Londino, Ahmed Lazrak, James F Collawn, Zsuzsanna Bebok, Kevin S Harrod, Sadis Matalon
The cystic fibrosis transmembrane conductance regulator (CFTR) and the amiloride-sensitive epithelial sodium channels (ENaC) are located in the apical membranes of airway and alveolar epithelial cells. These transporters play an important role in the regulation of lung fluid balance across airway and alveolar epithelia by being the conduits for chloride (Cl(-)) and bicarbonate (HCO3(-)) secretion and sodium (Na(+)) ion absorption, respectively. The functional role of these channels in the respiratory tract is to maintain the optimum volume and ionic composition of the bronchial pericilary fluid (PCL) and alveolar lining fluid (ALF) layers...
August 3, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28774694/improvement-of-fungal-disease-identification-and-management-combined-health-systems-and-public-health-approaches
#12
REVIEW
Donald C Cole, Nelesh P Govender, Arunaloke Chakrabarti, Jahit Sacarlal, David W Denning
More than 1·6 million people are estimated to die of fungal diseases each year, and about a billion people have cutaneous fungal infections. Fungal disease diagnosis requires a high level of clinical suspicion and specialised laboratory testing, in addition to culture, histopathology, and imaging expertise. Physicians with varied specialist training might see patients with fungal disease, yet it might remain unrecognised. Antifungal treatment is more complex than treatment for bacterial or most viral infections, and drug interactions are particularly problematic...
July 31, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28771584/extracellular-motility-and-cell-to-cell-transmission-of-enterohemorrhagic-e-coli-is-driven-by-espfu-mediated-actin-assembly
#13
Katrina B Velle, Kenneth G Campellone
Enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC) are closely-related pathogens that attach tightly to intestinal epithelial cells, efface microvilli, and promote cytoskeletal rearrangements into protrusions called actin pedestals. To trigger pedestal formation, EPEC employs the tyrosine phosphorylated transmembrane receptor Tir, while EHEC relies on the multivalent scaffolding protein EspFU. The ability to generate these structures correlates with bacterial colonization in several animal models, but the precise function of pedestals in infection remains unclear...
August 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28765628/nod2-gene-variants-confer-risk-for-secondary-sclerosing-cholangitis-in-critically-ill-patients
#14
Christoph Jüngst, Vanessa Stadlbauer, Matthias C Reichert, Vincent Zimmer, Susanne N Weber, Lisa Ofner-Ziegenfuß, Torsten Voigtländer, Walter Spindelböck, Peter Fickert, Gabriele I Kirchner, Frank Lammert, Tim O Lankisch, Marcin Krawczyk
Sclerosing cholangitis in critically ill patients (SC-CIP) is a progressive cholestatic disease of unknown aetiology characterized by chronic biliary infections. Hence we hypothesized that common NOD2 (nucleotide-binding oligomerisation domain containing 2) gene variants, known risk factors for Crohn's disease and bacterial translocation in liver cirrhosis, increase the odds of developing SC-CIP. Screening of 4,641 endoscopic retrograde cholangiography procedures identified 17 patients with SC-CIP, who were then genotyped for the three common NOD2 mutations (Cohort 1, discovery cohort)...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28761456/visceral-leishmaniasis-in-southeastern-iran-a-narrative-review
#15
REVIEW
Iraj Sharifi, Mohammad Reza Aflatoonian, Mohammad Hossein Daei Parizi, Ali Hosseininasab, Mahshid Mostafavi, Mehdi Bamorovat, Abass Aghaei Afshar, Mehdi Mohebali, Hossein Keshavarz, Hamid Daneshvar, Zahra Babaei, Hossein Mahmoudvand, Mohammad Ali Mohammadi, Fatemeh Sharifi, Mohammad Barati, Hossein Kamiabi, Tabandeh Khaleghi
BACKGROUND: Visceral leishmaniasis (VL) has strong links with poverty, substantial medical and veterinary impacts. This review aimed to focus in studies published during 1994-2016 on VL in southeastern Iran. METHODS: The present review is based on expert knowledge and historical studies published during the past 23 yr (1994-2016) on VL in southeastern Iran. In addition, related literature found in PubMed by using the keywords such as visceral leishmaniasis, kala-azar, and Leishmania infantum are included...
January 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28759413/the-yale-observation-scale-score-and-the-risk-of-serious-bacterial-infections-in-febrile-infants
#16
Lise E Nigrovic, Prashant V Mahajan, Stephen M Blumberg, Lorin R Browne, James G Linakis, Richard M Ruddy, Jonathan E Bennett, Alexander J Rogers, Leah Tzimenatos, Elizabeth C Powell, Elizabeth R Alpern, T Charles Casper, Octavio Ramilo, Nathan Kuppermann
OBJECTIVES: To assess the performance of the Yale Observation Scale (YOS) score and unstructured clinician suspicion to identify febrile infants ≤60 days of age with and without serious bacterial infections (SBIs). METHODS: We performed a planned secondary analysis of a prospective cohort of non-critically ill, febrile, full-term infants ≤60 days of age presenting to 1 of 26 participating emergency departments in the Pediatric Emergency Care Applied Research Network...
July 2017: Pediatrics
https://www.readbyqxmd.com/read/28758016/norgestimate-inhibits-staphylococcal-biofilm-formation-and-resensitizes-methicillin-resistant-staphylococcus-aureus-to-%C3%AE-lactam-antibiotics
#17
Yutaka Yoshii, Ken-Ichi Okuda, Satomi Yamada, Mari Nagakura, Shinya Sugimoto, Tetsuo Nagano, Takayoshi Okabe, Hirotatsu Kojima, Takeo Iwamoto, Kazuyoshi Kuwano, Yoshimitsu Mizunoe
Formation of bacterial biofilms on medical devices can cause severe or fatal infectious diseases. In particular, biofilm-associated infections caused by methicillin-resistant Staphylococcus aureus are difficult to eradicate because the biofilm is strongly resistant to antibiotics and the host immune response. There is no effective treatment for biofilm-associated infectionss, except for surgical removal of contaminated medical devices followed by antibiotic therapy. Here we show that norgestimate, an acetylated progestin, effectively inhibits biofilm formation by staphylococcal strains, including methicillin-resistant S...
2017: NPJ Biofilms and Microbiomes
https://www.readbyqxmd.com/read/28755067/efficacy-and-safety-of-human-intravenous-immunoglobulin-10-panzyga%C3%A2-in-patients-with-primary-immunodeficiency-diseases-a-two-stage-multicenter-prospective-open-label-study
#18
Michael Borte, Isaac R Melamed, Grazyna Pulka, Barbara Pyringer, Alan P Knutsen, Hans D Ochs, Roger H Kobayashi, Ai Lan Kobayashi, Sudhir Gupta, Magdalena Strach, William Smits, Anna Pituch-Noworolska, James N Moy
PURPOSE: To assess the efficacy and safety of panzyga® (intravenous immunoglobulin 10%) in preventing serious bacterial infections (SBIs) in patients with primary immunodeficiency diseases (PIDs), a prospective, open-label, multicenter, phase 3 study and an open-label extension study were undertaken. METHODS: Initially, the study drug (infusion rate ≤0.08 mL/kg/min) was administered at intervals of 3 or 4 weeks for 12 months, followed by 3 months of panzyga® at infusion rates increasing from 0...
July 29, 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28754292/freshwater-catfish-envenoming-in-a-tropical-country
#19
Sujeewa P B Thalgaspitiya, Buddhika T B Wijerathne, Nuwan P Siriwardhana
OBJECTIVE: Freshwater catfish are known to cause painful stings in humans. Stings usually cause mild envenomation and, in some instances, can lead to severe secondary bacterial infections. Sri Lanka is a tropical country where catfish stings are not rare. However, presenting signs and symptoms, complications, and management options are scarce in the literature. METHODS: A retrospective, descriptive, cross-sectional study was conducted by reviewing patient records in the university surgical units and surgical clinic in the teaching hospital in Anuradhapura, Sri Lanka, during 2015...
July 25, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28754138/serological-and-pcr-investigation-of-yersinia-pestis-in-potential-reservoir-hosts-from-a-plague-outbreak-focus-in-zambia
#20
S S Nyirenda, B M Hang'ombe, E Mulenga, B S Kilonzo
BACKGROUND: Plague is a bacterial zoonotic disease, caused by Yersinia pestis. Rodents are the natural hosts with fleas as the vehicle of disease transmission. Domestic and wild dogs and cats have also been identified as possible disease hosts. In Zambia, plague outbreaks have been reported in the Southern and Eastern regions in the last 20 years. Based on these observations, Y. pestis could possibly be endemically present in the area. METHODS: To substantiate such possibility, sera samples were collected from rodents, shrews, dogs and cats for detection of antibodies against Fraction 1 gene (Fra1) of Y...
July 28, 2017: BMC Research Notes
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