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https://www.readbyqxmd.com/read/29220665/mtorc1-activation-during-repeated-regeneration-impairs-somatic-stem-cell-maintenance
#1
Samantha Haller, Subir Kapuria, Rebeccah R Riley, Monique N O'Leary, Katherine H Schreiber, Julie K Andersen, Simon Melov, Jianwen Que, Thomas A Rando, Jason Rock, Brian K Kennedy, Joseph T Rodgers, Heinrich Jasper
The balance between self-renewal and differentiation ensures long-term maintenance of stem cell (SC) pools in regenerating epithelial tissues. This balance is challenged during periods of high regenerative pressure and is often compromised in aged animals. Here, we show that target of rapamycin (TOR) signaling is a key regulator of SC loss during repeated regenerative episodes. In response to regenerative stimuli, SCs in the intestinal epithelium of the fly and in the tracheal epithelium of mice exhibit transient activation of TOR signaling...
December 7, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/29220496/the-duration-of-influenza-vaccine-effectiveness-a-systematic-review-meta-analysis-and-meta-regression-of-test-negative-design-case-control-studies
#2
Barnaby Young, Sapna Sadarangani, Lili Jiang, Annelies Wilder-Smith, Mark I-Cheng Chen
Background: Whether influenza vaccination offers protection for the duration of an influenza season has recently been questioned following analysis of data from test-negative design (TND) case-control studies. Method: The published literature was systematically reviewed to identify TND studies which estimated change in vaccine effectiveness (VE) with time since vaccination. Results: Fourteen studies were identified through the literature search as meeting eligibility criteria...
December 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29220347/assessing-the-benefits-of-five-years-of-different-approaches-to-treatment-of-urogenital-schistosomiasis-a-score-project-in-northern-mozambique
#3
Anna E Phillips, Pedro H Gazzinelli-Guimaraes, Herminio O Aurelio, Josefo Ferro, Rassul Nala, Michelle Clements, Charles H King, Alan Fenwick, Fiona M Fleming, Neerav Dhanani
BACKGROUND: In Mozambique, schistosomiasis is highly endemic across the whole country. The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) coordinates a five-year study that has been implemented in various African countries, including Mozambique. The overall goal of SCORE was to better understand how to best apply preventive chemotherapy with praziquantel (PZQ) for schistosomiasis control by evaluating the impact of alternative treatment approaches. METHODS: This was a cluster-randomised trial that compared the impact of different treatment strategies in study areas with prevalence among school children of ≥21% S...
December 8, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29220320/virtual-view-synthesis-for-free-viewpoint-video-and-multiview-video-compression-using-gaussian-mixture-modelling
#4
D M Motiur Rahaman, Manoranjan Paul
High quality virtual views need to be synthesized from adjacent available views for free viewpoint video and multiview video coding (MVC) to provide users with a more realistic 3D viewing experience of a scene. View synthesis techniques suffer from poor rendering quality due to holes created by occlusion and rounding integer error through warping. To remove the holes in the virtual view, the existing techniques use spatial and temporal correlation in intra/inter-view images and depth maps. However, they still suffer quality degradation in the boundary region of foreground and background areas due to the low spatial correlation in texture images and low correspondence in inter-view depth maps...
March 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29220292/rhabdomyosarcoma-ewing-sarcoma-and-other-round-cell-sarcomas
#5
Alberto S Pappo, Uta Dirksen
Several recent advances have been made in the diagnosis and therapy of malignant small round cell tumors that affect children, particularly in rhabdomyosarcoma, Ewing sarcoma, and other round cell sarcomas. These advances have provided new insights into the pathologic, histologic, and genomic characterization of specific tumor subtypes, which has led to the identification of novel therapeutic targets and improved stratification of risk. This has, in turn, led to improved efficacy in clinical trials of new drug combinations, thereby increasing the survival of patients with newly diagnosed and refractory or recurrent round cell sarcomas...
December 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29218653/differential-diagnosis-of-pancreatic-epidermoid-cyst-without-a-solid-component-residual-splenic-tissue-vs-mucinous-cystic-neoplasm
#6
Kousei Ishigami, Akihiro Nishie, Hiroyuki Irie, Yoshiki Asayama, Yasuhiro Ushijima, Yukihisa Takayama, Daisule Okamoto, Nobuhiro Fujita, Takao Ohtsuka, Tetsuhide Ito, Naoki Mochidome, Hiroshi Honda
PURPOSE: The purpose of this study was to clarify whether there are differences in imaging findings between pancreatic epidermoid cyst (EDC) without a solid component (residual splenic tissue) and mucinous cystic neoplasm (MCN). MATERIALS AND METHODS: The study group consisted of histologically proven EDC (eight cases) and MCN (20 cases). CT and MRI findings were compared on the following imaging findings: the shape of the cystic lesions and the presence or absence of septum, calcification, and high-intensity fluid on T1- and diffusion-weighted images (b factor = 1000)...
December 7, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29218553/how-to-analyze-and-present-sas-data-for-publication
#7
Martha Brennich, Petra Pernot, Adam Round
SAS is a powerful technique to investigate oligomeric state and domain organization of macromolecules, e.g. proteins and nucleic acids, under physiological, functional and even time resolved conditions. However, reconstructing three dimensional structures from SAS data is inherently ambiguous, as no information about orientation and phase is available. In addition experimental artifacts such as radiation damage, concentration effects and incorrect background subtraction can hinder the interpretation of even lead to wrong results...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29218480/discussion-augmentation-mastopexy-with-a-dermal-encapsulated-round-or-anatomic-autoprosthesis
#8
Katherine Shaum, Ahmed Afifi
No abstract text is available yet for this article.
December 7, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29218215/leiomyoma-of-round-ligament-mimicking-an-incarcerated-inguinal-hernia-report-of-a-rare-case
#9
Christoforos Efthimiadis, Aristeidis Ioannidis, Marios Grigoriou, Konstantinia Kofina, Domniki Gerasimidou
Inguinal hernia is a common condition and may contain small or large bowel, omentum or other tissues. Leiomyomas of a round ligament are a rare condition occurring predominantly in premenopausal women. Abdominal, inguinal and vulvar locations have been described. Rare situations have been reported in which leiomyomas resemble to an incarcerated inguinal hernia. We describe a rare case of a leiomyoma of a round ligament in a young Caucasian female mimicking an incarcerated inguinal hernia. The treatment was surgical and we were able to remove the leiomyoma of the round ligament successfully...
November 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29217759/opposing-roles-of-dendritic-cell-subsets-in-experimental-gn
#10
Sebastian Brähler, Bernd H Zinselmeyer, Saravanan Raju, Maximilian Nitschke, Hani Suleiman, Brian T Saunders, Michael W Johnson, Alexander M C Böhner, Susanne F Viehmann, Derek J Theisen, Nicole M Kretzer, Carlos G Briseño, Konstantin Zaitsev, Olga Ornatsky, Qing Chang, Javier A Carrero, Jeffrey B Kopp, Maxim N Artyomov, Christian Kurts, Kenneth M Murphy, Jeffrey H Miner, Andrey S Shaw
Dendritic cells (DCs) are thought to form a dendritic network across barrier surfaces and throughout organs, including the kidney, to perform an important sentinel function. However, previous studies of DC function used markers, such as CD11c or CX3CR1, that are not unique to DCs. Here, we evaluated the role of DCs in renal inflammation using a CD11c reporter mouse line and two mouse lines with DC-specific reporters, Zbtb46-GFP and Snx22-GFP. Multiphoton microscopy of kidney sections confirmed that most of the dendritically shaped CD11c+ cells forming a network throughout the renal interstitium expressed macrophage-specific markers...
December 7, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29217673/more-than-sixty-origins-of-pantoporate-pollen-in-angiosperms
#11
Charlotte Prieu, Hervé Sauquet, Pierre-Henri Gouyon, Béatrice Albert
PREMISE OF THE STUDY: Apertures in pollen grains are key structures of the wall, involved in pollen tube germination and exchanges with the environment. Aperture types in angiosperms are diverse, but pollen with one and three apertures (including monosulcate and tricolpate, respectively) are the two most common types. Here, we investigate the phylogenetic distribution in angiosperms of pollen with many round, scattered apertures called pantoporate pollen. METHODS: We constructed a morphological data set with species producing pantoporate pollen and representative angiosperm species with other pollen types, sampled from every angiosperm order, with a total of 1260 species distributed in 330 families...
December 7, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/29217525/integration-of-mobile-devices-to-facilitate-patient-care-and-teaching-during-family-centered-rounds
#12
Angela S Byrd, Pamela M McMahon, Richard J Vath, Michael Bolton, Melissa Roy
OBJECTIVES: The increasing prevalence of mobile devices in clinical settings has the potential to improve both patient care and education. The benefits are particularly promising in the context of family-centered rounds in inpatient pediatric settings. We aimed to increase mobile device usage by inpatient rounding teams by 50% in 6 months. We hoped to demonstrate that use of mobile devices would improve access to patient care and educational information and to determine if use would improve efficiency and perceptions of clinical teaching...
December 7, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/29217274/contact-wear-of-artificial-denture-teeth
#13
Verena Preis, Sebastian Hahnel, Michael Behr, Martin Rosentritt
PURPOSE: High wear resistance of denture teeth preserves good occlusal relationship and sufficient parafunctional stability. This in-vitro investigation aimed to determine and compare the wear performance of different artificial denture teeth. METHODS: Denture teeth of fifteen commercial products (n=8/group) were loaded in a pin-on-block design using steatite antagonists (d=3mm). Cyclic loading (50 N) was applied for 120,000 loadings (f=1.2Hz) with simultaneous thermal cycling (distilled water, 5°C/55°C, 2min/cycle)...
December 4, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/29217019/effect-of-music-on-surgical-skill-during-simulated-intraocular-surgery
#14
Ralph Kyrillos, Mathieu Caissie
OBJECTIVE: To evaluate the effect of Mozart music compared to silence on anterior segment surgical skill in the context of simulated intraocular surgery. DESIGN: Prospective stratified and randomized noninferiority trial. PARTICIPANTS: Fourteen ophthalmologists and 12 residents in ophthalmology. METHODS: All participants were asked to perform 4 sets of predetermined tasks on the EyeSI surgical simulator (VRmagic, Mannheim, Germany)...
December 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29216908/clinical-and-neuropathological-features-of-als-ftd-with-tia1-mutations
#15
Veronica Hirsch-Reinshagen, Cyril Pottier, Alexandra M Nicholson, Matt Baker, Ging-Yuek R Hsiung, Charles Krieger, Pheth Sengdy, Kevin B Boylan, Dennis W Dickson, Marsel Mesulam, Sandra Weintraub, Eileen Bigio, Lorne Zinman, Julia Keith, Ekaterina Rogaeva, Sasha A Zivkovic, David Lacomis, J Paul Taylor, Rosa Rademakers, Ian R A Mackenzie
Mutations in the stress granule protein T-cell restricted intracellular antigen 1 (TIA1) were recently shown to cause amyotrophic lateral sclerosis (ALS) with or without frontotemporal dementia (FTD). Here, we provide detailed clinical and neuropathological descriptions of nine cases with TIA1 mutations, together with comparisons to sporadic ALS (sALS) and ALS due to repeat expansions in C9orf72 (C9orf72+). All nine patients with confirmed mutations in TIA1 were female. The clinical phenotype was heterogeneous with a range in the age at onset from late twenties to the eighth decade (mean = 60 years) and disease duration from one to 6 years (mean = 3 years)...
December 7, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29216806/an-industry-update-the-latest-developments-in-therapeutic-delivery
#16
Iain Simpson
This industry update covers the period from 1 September through 30 September 2017, and is based on information sourced from company press releases, scientific literature, patents and various news websites. The month saw the US FDA approve three new molecular entities, Aliqopa (copanlisib dihydrochloride) (Bayer Healthcare); Solosec (secnidazole) (Symbiomix Therapeutics) and Verzenio (abemaciclib) (Eli Lilly and Co). Intarcia Therapeutics Inc. has its application for approval of a novel drug device combination of exenatide for the treatment of diabetes rejected by FDA but said that it will work to address the concerns and refile the application...
January 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29216266/identification-and-genetic-characterization-of-hepacivirus-and-pegivirus-in-commercial-equine-serum-products-in-china
#17
Gang Lu, Ji Huang, Qiliang Yang, Haibin Xu, Peixin Wu, Cheng Fu, Shoujun Li
Equine hepacivirus (EqHV), equine pegivirus (EPgV) and Theiler's disease-associated virus (TDAV) are three novel equine viruses in the family Flaviviridae. EqHV and EPgV have been identified to circulate in the equine population worldwide, whereas TDAV has not been detected in equines since the first reported case. To date, no studies have focused on investigating EqHV, EPgV and TDAV in commercial equine sera or equine blood products in China. Considering the potential threat of EqHV, EPgV and TDAV to biosecurity and considering their possible influences on research results, equine sera for cell culture propagation and pregnant mare serum gonadotropin (PMSG) were purchased from different companies in China and investigated for EqHV, EPgV and TDAV in this study...
2017: PloS One
https://www.readbyqxmd.com/read/29216244/optimizing-household-survey-methods-to-monitor-the-sustainable-development-goals-targets-6-1-and-6-2-on-drinking-water-sanitation-and-hygiene-a-mixed-methods-field-test-in-belize
#18
Shane M Khan, Robert E S Bain, Karsten Lunze, Turgay Unalan, Bo Beshanski-Pedersen, Tom Slaymaker, Richard Johnston, Attila Hancioglu
BACKGROUND: The Sustainable Development Goals (SDGs) require household survey programmes such as the UNICEF-supported Multiple Indicator Cluster Surveys (MICS) to enhance data collection to cover new indicators. This study aims to evaluated methods for assessing water quality, water availability, emptying of sanitation facilities, menstrual hygiene management and the acceptability of water quality testing in households which are key to monitoring SDG targets 6.1 and 6.2 on drinking Water, Sanitation and Hygiene (WASH) and emerging issues...
2017: PloS One
https://www.readbyqxmd.com/read/29216220/retarded-germination-of-nicotiana-tabacum-seeds-following-insertion-of-exogenous-dna-mimics-the-seed-persistent-behavior
#19
Elisabetta Onelli, Alessandra Moscatelli, Assunta Gagliardi, Mauro Zaninelli, Luca Bini, Antonella Baldi, Marco Caccianiga, Serena Reggi, Luciana Rossi
Tobacco seeds show a coat-imposed dormancy in which the seed envelope tissues (testa and endosperm) impose a physical constraint on the radicle protrusion. The germination-limiting process is represented by the endosperm rupture which is induced by cell-wall weakening. Transgenic tobacco seeds, obtained by insertion of exogenous genes codifying for seed-based oral vaccines (F18 and VT2eB), showed retarded germination with respect to the wild type and modified the expression of endogenous proteins. Morphological and proteomic analyses of wild type and transgenic seeds revealed new insights into factors influencing seed germination...
2017: PloS One
https://www.readbyqxmd.com/read/29216120/cavity-length-matching-and-optical-resonances-in-a-raman-laser-with-the-multimode-pump-source
#20
Ruslan V Chulkov, Vasyli Y Markevich, Ahmed Y Alyamani, Evgenii A Cheshev, Valentin A Orlovich
We report on the observation of local reduction in generation threshold and enhancement in the output energy of a nanosecond Raman laser when the round-trip time of its cavity is matched with that of a longitudinally multimode pump laser or related to the latter as a ratio of small integers. We refer both observations to the synchronous pump effect originating from the periodicity in the small-scale intensity structure of the pump pulse.
December 1, 2017: Optics Letters
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