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https://www.readbyqxmd.com/read/29453757/localization-of-epithelial-sodium-channel-enac-and-cftr-in-the-germinal-epithelium-of-the-testis-sertoli-cells-and-spermatozoa
#1
Sachin Sharma, Aaron Hanukoglu, Israel Hanukoglu
Spermatogenesis starts within the seminiferous tubules of the testis by mitotic division of spermatogonia that produces spermatocytes. Meiotic division of these spermatocytes produces haploid spermatids that differentiate into spermatozoa. In this study, we examined the expression of ENaC and CFTR (a Cl - channel) in rat testicular sections using confocal microscopic immunofluorescence. The structural integrity of the seminiferous tubule sections was verified by precise phalloidin staining of the actin fibers located abundantly at both basal and adluminal tight junctions...
February 16, 2018: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29453648/supplemental-diagnosis-of-gyrodactylus-fairporti-van-cleave-1921-monogenea-from-1-month-old-black-bullhead-ameiurus-melas-in-riverside-pools-in-wisconsin
#2
Eric Leis, Russell Easy, David Cone
Samples of Gyrodactylus fairporti Van Cleave, 1921 from young-of-the-year black bullhead (Ameiurus melas) stranded in riverside pools of the Black River (La Crosse County,) WI, USA, are used to supplement the species diagnosis, including new details on the marginal hook sickles, the male copulatory organ (MCO), and 18S rRNA gene sequence data. The anchors of G. fairporti are relatively long and thin, 58.2 ± 1.2 μm in length; roots 15.5 ± 1.0 μm; shaft 38.1 ± 1.5 μm; point 31.3 ± 1.5 μm. The ventral bar is 19...
February 17, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29453594/time-to-first-event-versus-recurrent-event-analysis-points-to-consider-for-selecting-a-meaningful-analysis-strategy-in-clinical-trials-with-composite-endpoints
#3
Geraldine Rauch, Meinhard Kieser, Harald Binder, Antoni Bayes-Genis, Antje Jahn-Eimermacher
BACKGROUND: Composite endpoints combining several event types of clinical interest often define the primary efficacy outcome in cardiologic trials. They are commonly evaluated as time-to-first-event, thereby following the recommendations of regulatory agencies. However, to assess the patient's full disease burden and to identify preventive factors or interventions, subsequent events following the first one should be considered as well. This is especially important in cohort studies and RCTs with a long follow-up leading to a higher number of observed events per patients...
February 16, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29453422/operando-characterization-of-cathodic-reactions-in-a-liquid-state-lithium-oxygen-micro-battery-by-scanning-transmission-electron-microscopy
#4
Pan Liu, Jiuhui Han, Xianwei Guo, Yoshikazu Ito, Chuchu Yang, Shoucong Ning, Takeshi Fujita, Akihiko Hirata, Mingwei Chen
Rechargeable non-aqueous lithium-oxygen batteries with a large theoretical capacity are emerging as a high-energy electrochemical device for sustainable energy strategy. Despite many efforts made to understand the fundamental Li-O 2 electrochemistry, the kinetic process of cathodic reactions, associated with the formation and decomposition of a solid Li 2 O 2 phase during charging and discharging, remains debate. Here we report direct visualization of the charge/discharge reactions on a gold cathode in a non-aqueous lithium-oxygen micro-battery using liquid-cell aberration-corrected scanning transmission electron microscopy (STEM) combining with synchronized electrochemical measurements...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453324/incidence-and-predictors-of-perioperative-complications-with-transvenous-lead-extractions-real-world-experience-with-national-cardiovascular-data-registry
#5
Nitesh Sood, David T Martin, Rachel Lampert, Jeptha P Curtis, Craig Parzynski, Jude Clancy
BACKGROUND: Transvenous lead extraction is an integral part of management of patients with cardiovascular implantable electronic devices. Real-world incidence and predictors of perioperative complications in extractions involving implantable cardioverter-defibrillator leads have not been described in detail. METHODS AND RESULTS: Data from the National Cardiovascular Data Registry Implantable Cardioverter-Defibrillator Registry were analyzed. Lead extraction was defined as removal of leads implanted for >1 year...
February 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29452830/usefulness-of-reconstructed-3d-images-for-cochlear-implantation-in-a-case-with-a-facial-nerve-anomaly
#6
Kenichi Nakamura, Mari Shimada Dias, Toru Sasaki, Hisashi Sugimoto, Miyako Hatano, Makoto Ito
Facial nerve anomalies are a potential problem in patients with cochleovestibular malformations. A case of cochlear implant (CI) surgery in the presence of intra-temporalbone facial nerve bifurcation is presented. During the first surgery, the facial nerve bifurcation obscured the promontory and round window. It was difficult to perform cochleostomy because of the lack of landmarks of the basal turn of the cochlea, and the first surgical attempt at cochleostomy was abandoned. A repeat CT scan was performed after the first surgery with reconstructed 3D images of the temporal bone and the cochlea, and then the cochlea was successfully opened at revision surgery...
February 14, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29452787/a-modelling-study-to-evaluate-the-costs-and-effects-of-lowering-the-starting-age-of-population-breast-cancer-screening
#7
Rositsa G Koleva-Kolarova, Alicja M Daszczuck, Chris de Jonge, Mohd Kahlil Abu Hantash, Zhuozhao Z Zhan, Erik Jan Postema, Talitha L Feenstra, Ruud M Pijnappel, Marcel J W Greuter, Geertruida H de Bock
BACKGROUND: Because the incidence of breast cancer increases between 45 and 50years of age, a reconsideration is required of the current starting age (typically 50years) for routine mammography. Our aim was to evaluate the quantitative benefits, harms, and cost-effectiveness of lowering the starting age of breast cancer screening in the Dutch general population. METHODS: Economic modelling with a lifelong perspective compared biennial screening for women aged 48-74years and for women aged 46-74years with the current Dutch screening programme, which screen women between the ages of 50 and 74years...
March 2018: Maturitas
https://www.readbyqxmd.com/read/29451738/well-differentiated-grade-3-pancreatic-neuroendocrine-tumors-compared-with-related-neoplasms-a-morphologic-study
#8
Carlie S Sigel, Vitor Werneck Krauss Silva, Michelle D Reid, David Chhieng, Olca Basturk, Keith M Sigel, Tanisha D Daniel, David S Klimstra, Laura H Tang
BACKGROUND: Pancreatic neuroendocrine neoplasms with a Ki-67 labeling index greater than 20% were reclassified in 2017 by the World Health Organization into well differentiated (WD) and poorly differentiated grade 3 neuroendocrine carcinoma (NEC). The authors describe the cytologic features of grade 3 WD pancreatic neuroendocrine neoplasms compared with grade 2 neoplasms and NEC. METHODS: Fine-needle aspirates from 65 pancreatic neuroendocrine neoplasms were reviewed, and their cytomorphologic features were compared across grade 2, WD grade 3, and PD small cell type (PD-S), large cell type (PD-L), and type not otherwise specified (PD-NOS) neoplasms...
February 16, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29451372/morphological-spectra-of-adult-human-stellate-ganglia-implications-for-thoracic-sympathetic-denervation
#9
Oh Jin Kwon, Shrita Pendekanti, Jacob N Fox, Jane Yanagawa, Michael C Fishbein, Kalyanam Shivkumar, H Wayne Lambert, Olujimi Ajijola
BACKGROUND: Cardiac sympathetic denervation (CSD) to treat ventricular arrhythmias (VAs) requires transection at the middle or lower third of stellate (cervicothoracic) ganglia (SG). However, the morphological appearance of the adult SG and distribution of neuronal somata within it are not well described. OBJECTIVE: To determine the morphology of left and right SG (LSG and RSG) and the distribution of somata within. METHODS: LSG and RSG (n=28) from 14 embalmed adult cadavers were dissected intact...
February 16, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29451344/a-case-of-microscopic-multiple-sclerosing-pneumocytoma
#10
Hitomi Kawai, Norio Takayashiki, Haruo Otani, Shingo Sakashita, Masayuki Noguchi
Sclerosing pneumocytoma is a rare tumor of the lung, commonly affecting middle-aged women, and is mostly isolated. Although this tumor is thought to be derived from primitive respiratory epithelial cells, the characteristics of the precursor cells are still unknown. A 19-year-old woman presented with multiple nodules in the right lung. Partial resection of the right middle lobe was performed, and seven sclerosing pneumocytomas, including four that were microscopic, were detected. The latter showed a simple papillary pattern, and three of them consisted of only round cell-like cells (single population)...
February 16, 2018: Pathology International
https://www.readbyqxmd.com/read/29451220/critical-role-of-sdf-1-cxcr4-signaling-pathway-in-stem-cell-homing-in-the-deafened-rat-cochlea-after-acoustic-trauma
#11
Ali Asghar Peyvandi, Navid Ahmady Roozbahany, Hassan Peyvandi, Hojjat-Allah Abbaszadeh, Niloofar Majdinasab, Mohammad Faridan, Somayeh Niknazar
Previous animal studies have shown that stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor-4 (CXCR4) signaling pathway plays an important role in the targeted migration of bone marrow-derived mesenchymal stem cells (BMSCs) to the injured area. In the present study, we aimed to investigate the potential role of chemotactic SDF-1/CXCR4 signaling pathway in the homing of transplanted BMSCs to the injured cochlea after noise-induced hearing loss (NIHL) in a rat model. White noise exposure (110 dB) paradigm was used for hearing loss induction in male rats for 6 hours in 5 days...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29451134/a-new-route-to-gold-nanoflowers
#12
Ferenc Liebig, Ricky Henning, Radwan Sarhan, Claudia Prietzel, Matias Bargheer, Joachim Koetz
Catanionic vesicles spontaneously formed by mixing the anionic surfactant AOT with the cationic surfactant CTAB were used as a reducing medium to produce gold clusters, which are embedded well ordered into the template phase. The gold clusters can be used as seeds in the following growth process by adding ascorbic acid as a mild reducing component. When the ascorbic acid is added very slowly in an ice bath round-edged gold nanoflowers were produced. When the same experiments were performed at room temperature in presence of Ag+ ions sharp-edged nanoflowers can be synthesized...
February 16, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29450810/characterisation-of-a-new-species-of-trichodorus-cobb-1913-triplonchida-trichodoridae-from-iran-based-on-morphological-and-molecular-data
#13
Ramezan Asghari, Ali Eskandari, Zahra Tanha Maafi, Wilfrida Decraemer
Trichodorus zanjanensis n. sp., collected from the rhizosphere of wild almond tree (Amygdalus scoparia Spach) in Zanjan Province, Iran, is described and illustrated based on morphological and molecular data. The new species is characterised by its body length (772-819 μm in males; 704-953 μm in females), and in having medium-sized onchiostyle (60-64 μm in males; 59-65 μm in females) and a short dorsal overlap of the intestine. Males of the new species have two ventromedian cervical papillae posterior to onchiostyle region, ventrally curved spicules, smooth, long and wide manubrium, gradually continuing in a narrower anterior part of the blade provided with bristles and marked from the wider and transversely striated main part of the blade, tapered towards distal end, three ventromedian precloacal supplements, the posterior one (SP1) situated at the level of anterior blade and gubernaculum situated at 24-25 μm from the cloaca...
February 15, 2018: Systematic Parasitology
https://www.readbyqxmd.com/read/29450216/a-multidisciplinary-delphi-consensus-based-checklist-to-define-clinical-documentation-tools-for-both-routine-and-research-purposes
#14
Cecilia Veraar, Paul Hasler, Michael Schirmer
Background: To the best of our knowledge, a strategic approach to define the contents of structured clinical documentation tools for both clinical routine patient care and research purposes has not been reported so far, although electronic health record will become more and more structured and detailed in the future. Objective: To achieve an interdisciplinary consensus on a checklist to be considered for the preparation of disease- and situation-specific clinical documentation tools...
January 2018: Health Services Research and Managerial Epidemiology
https://www.readbyqxmd.com/read/29449780/tubular-adenoma-of-the-breast-a-clinicopathologic-study-of-a-series-of-9-cases
#15
Boubacar Efared, Ibrahim S Sidibé, Souley Abdoulaziz, Nawal Hammas, Laila Chbani, Hinde El Fatemi
Tubular adenoma of the breast is one of the most rare benign neoplasms, accounting for only 0.13% to 1.7% of all breast benign tumors. Little is known about this rare neoplasm as the current literature offers only some case reports or a few number of small series. The aim of our study is to provide some clinicopathologic features of the breast tubular adenoma. We retrospectively analyzed at our department of pathology all cases of breast tubular adenomas confirmed by immunohistochemistry over a period of 9 years (2009-2017)...
2018: Clinical Medicine Insights. Pathology
https://www.readbyqxmd.com/read/29449770/adverse-events-following-cervical-manipulative-therapy-consensus-on-classification-among-dutch-medical-specialists-manual-therapists-and-patients
#16
Hendrikus A Kranenburg, Sandra E Lakke, Maarten A Schmitt, Cees P Van der Schans
Objectives: To obtain consensus-based agreement on a classification system of adverse events (AE) following cervical spinal manipulation. The classification system should be comprised of clear definitions, include patients' and clinicians' perspectives, and have an acceptable number of categories. Methods: Design : A three-round Delphi study. Participants : Thirty Dutch participants (medical specialists, manual therapists, and patients) participated in an online survey...
December 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/29449611/seasonal-resource-conditions-favor-a-summertime-increase-in-north-pacific-diatom-diazotroph-associations
#17
Christopher L Follett, Stephanie Dutkiewicz, David M Karl, Keisuke Inomura, Michael J Follows
In the North Pacific Subtropical Gyre (NPSG), an annual pulse of sinking organic carbon is observed at 4000 m between July and August, driven by large diatoms found in association with nitrogen fixing, heterocystous, cyanobacteria: Diatom-Diazotroph Associations (DDAs). Here we ask what drives the bloom of DDAs and present a simplified trait-based model of subtropical phototroph populations driven by observed, monthly averaged, environmental characteristics. The ratio of resource supply rates favors nitrogen fixation year round...
February 15, 2018: ISME Journal
https://www.readbyqxmd.com/read/29449145/antithrombotic-therapy-following-venous-stenting-international-delphi-consensus
#18
Kristijonas Milinis, Ankur Thapar, Joseph Shalhoub, Alun H Davies
OBJECTIVE/BACKGROUND: Deep venous stenting is increasingly used in the treatment of deep venous obstruction; however, there is currently no consensus regarding post-procedural antithrombotic therapy. The aim of the present study was to determine the most commonly used antithrombotic regimens and facilitate global consensus. METHODS: An electronic survey containing three clinical scenarios on venous stenting for non-thrombotic iliac vein lesions, acute deep vein thrombosis (DVT), and post-thrombotic syndrome was distributed to five societies whose members included vascular surgeons, interventional radiologists, and haematologists...
February 12, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29449060/the-aprosody-of-schizophrenia-computationally-derived-acoustic-phonetic-underpinnings-of-monotone-speech
#19
Michael T Compton, Anya Lunden, Sean D Cleary, Luca Pauselli, Yazeed Alolayan, Brooke Halpern, Beth Broussard, Anthony Crisafio, Leslie Capulong, Pierfrancesco Maria Balducci, Francesco Bernardini, Michael A Covington
OBJECTIVE: Acoustic phonetic methods are useful in examining some symptoms of schizophrenia; we used such methods to understand the underpinnings of aprosody. We hypothesized that, compared to controls and patients without clinically rated aprosody, patients with aprosody would exhibit reduced variability in: pitch (F0), jaw/mouth opening and tongue height (formant F1), tongue front/back position and/or lip rounding (formant F2), and intensity/loudness. METHODS: Audiorecorded speech was obtained from 98 patients (including 25 with clinically rated aprosody and 29 without) and 102 unaffected controls using five tasks: one describing a drawing, two based on spontaneous speech elicited through a question (Tasks 2 and 3), and two based on reading prose excerpts (Tasks 4 and 5)...
February 12, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29449028/collection-of-human-biological-samples-for-research-purpose-key-challenges-and-patients%C3%A2-perspectives
#20
Céline Verstuyft, Zeina Antoun, Dominique Deplanque
The development and the access to collections of human biological samples is one of the major challenges for health research. In recent years, biological resource centres (BRCs) have developed in such a way that they provide all activities relating to the handling of samples. In this context, France is undoubtedly a pioneering country, because most of the biological collections available were created on the basis of themed research projects, which involved a particular donor phenotype. The round table was an opportunity to emphasise the persistence of some pitfalls particularly in relation to ensuring the consistency of different regulatory pathways...
February 12, 2018: Thérapie
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