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https://www.readbyqxmd.com/read/29050367/expression-and-clinical-association-of-programmed-cell-death-1-programmed-death-ligand-1-and-cd8-lymphocytes-in-primary-sarcomas-is-subtype-dependent
#1
Anke E M van Erp, Yvonne M H Versleijen-Jonkers, Melissa H S Hillebrandt-Roeffen, Laurens van Houdt, Mark A J Gorris, Laura S van Dam, Thomas Mentzel, Marije E Weidema, C Dilara Savci-Heijink, Ingrid M E Desar, Hans H M Merks, Max M van Noesel, Janet Shipley, Winette T A van der Graaf, Uta E Flucke, Friederike A G Meyer-Wentrup
In order to explore the potential of immune checkpoint blockade in sarcoma, we investigated expression and clinical relevance of programmed cell death-1 (PD-1), programmed death ligand-1 (PD-L1) and CD8 in tumors of 208 sarcoma patients. Primary untreated osteosarcoma (n = 46), Ewing sarcoma (n = 32), alveolar rhabdomyosarcoma (n = 20), embryonal rhabdomyosarcoma (n = 77), synovial sarcoma (n = 22) and desmoplastic small round cell tumors (DSRCT) (n = 11) were examined immunohistochemically. PD-L1 expression was predominantly detected in alveolar and embryonal rhabdomyosarcomas (15% and 16%, respectively)...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050077/-detection-of-fusion-gene-transcript-in-formalin-fixed-paraffin-embedded-myxoid-round-cell-liposarcoma-tissues-by-improved-reverse-transcription-polymerase-chain-reaction
#2
Y H Hao, X W Chen, L Wang, X B Tang
No abstract text is available yet for this article.
October 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29049881/effect-of-the-alkanoyl-group-position-at-the-glycerol-backbone-on-the-monolayer-characteristics-demonstrated-by-2-monopalmitoyl-rac-glycerol
#3
Dieter Vollhardt, Gerald Brezesinski, Rainer Rudert, Antonio Gonzalez
The influence of the position of the aliphatic chain at the glycerol backbone has been basically unknown. Solely the results of 2-monopalmitoyl-rac-glycerol obtained at ≥13 °C indicated an essential influence of the position of the palmitoyl group at the glycerol backbone, substantiated by a disordered packing of the alkyl chains. Therefore, the present study extends the comprehensive characterization of 2-monopalmitoyl-rac-glycerol monolayers to the low temperature range for highlighting the effect of the position of the aliphatic chain at the glycerol backbone of monoalkanoylglycerolester monolayers...
October 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29049686/national-practice-variation-in-pneumonectomy-perioperative-care-among-canadian-thoracic-surgeons
#4
Biniam Kidane, John K Peel, Andrew Seely, Richard A Malthaner, Christian Finley, Sean Grondin, Brian E Louie, Sadeesh Srinathan, Gail E Darling
OBJECTIVES: Our objective was to assess perioperative pneumonectomy practices among Canadian thoracic surgeons as part of a quality-improvement initiative to determine practice variability and identify areas for study/improvement. METHODS: After several rounds of survey development and piloting, a 29-item survey was distributed using the Dillman method to all practicing members of the Canadian Association of Thoracic Surgeons. RESULTS: The response rate was 87% (62 of 71)...
July 28, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29048992/eurasian-red-squirrels-show-little-seasonal-variation-in-metabolism-in-food-enriched-habitat
#5
James M Turner, Stephanie Reher, Lisa Warnecke, Kathrin H Dausmann
Energy expenditure and ambient temperature (Ta) are intrinsically linked through changes in an animal's metabolic rate. While the nature of this relationship is stable, the breadth of change in thermoregulatory cost varies with body size and physiological acclimatization to season. To explore seasonal metabolic changes of small mammals, we studied a population of Eurasian red squirrels (Sciurus vulgaris) in a seminatural environment with a year-round supply of natural and supplemented food. In each season we measured the metabolic rate of wild-caught red squirrels, using open-flow respirometry, and hypothesized that individuals would make adjustments to contend with seasonal weather conditions...
November 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/29048745/inhibition-of-yeast-to-filamentous-growth-transitions-in-candida-albicans-by-a-small-molecule-inducer-of-mammalian-apoptosis
#6
Joy Goffena, Kurt A Toenjes, David K Butler
The opportunistic fungal pathogen of humans Candida albicans is able to grow in different morphological forms such as round or oval yeasts and filamentous hyphae and pseudohyphae. Morphogenesis, the ability to switch between the yeast and filamentous growth forms, is important for adapting to new microenvironments in the human host and for pathogenesis. The molecular pathways governing morphogenesis are complex and incompletely understood. Previously, we identified several small organic molecules that specifically inhibit the initiation of hyphal growth in C...
October 19, 2017: Yeast
https://www.readbyqxmd.com/read/29048013/adaptive-optics-retinal-imaging-with-automatic-detection-of-the-pupil-and-its-boundary-in-real-time-using-shack-hartmann-images
#7
Alberto de Castro, Lucie Sawides, Xiaofeng Qi, Stephen A Burns
Retinal imaging with an adaptive optics (AO) system usually requires that the eye be centered and stable relative to the exit pupil of the system. Aberrations are then typically corrected inside a fixed circular pupil. This approach can be restrictive when imaging some subjects, since the pupil may not be round and maintaining a stable head position can be difficult. In this paper, we present an automatic algorithm that relaxes these constraints. An image quality metric is computed for each spot of the Shack-Hartmann image to detect the pupil and its boundary, and the control algorithm is applied only to regions within the subject's pupil...
August 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047484/characterizing-ice-particles-using-two-dimensional-reflections-of-a-lidar-beam
#8
M Goerke, Z Ulanowski, G Ritter, E Hesse, R R Neely, L Taylor, R A Stillwell, P H Kaye
We report a phenomenon manifesting itself as brief flashes of light on the snow's surface near a lidar beam. The flashes are imaged and interpreted as specular reflection patterns from individual ice particles. Such patterns have a two-dimensional structure and are similar to those previously observed in forward scattering. Patterns are easiest to capture from particles with well-defined horizontal facets, such as near-horizontally aligned plates. The patterns and their position can be used to determine properties such as ice particle shape, size, roughness, alignment, and altitude...
July 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047471/teaching-rainbows-with-simulations-revisiting-minnaert-s-lab-experiment
#9
Francisco L Naranjo-Correa, Guadalupe Martinez-Borreguero, Angel Luis Pérez-Rodriguez, Pedro J Pardo-Fernandez, Maria Isabel Suero-Lopez
This work presents an educational simulation to support students' learning about the formation of the rainbow. The main aim of the simulation is to provide our students with a didactic tool in addition to their traditional laboratory practice, which can be easily implemented in e-learning teaching platforms. A system consisting of a flask filled with water and a screen with a rounded aperture placed between the sun and the flask was simulated; this way a faint rainbow was seen on the simulated screen. The interactive nature of the simulation allowed the students to perform some alterations that would be impossible to do in the real world; thus, the observed rainbow deviated from the simplest model...
July 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047387/isothermal-diagnostic-assays-for-the-detection-of-soil-transmitted-helminths-based-on-the-smartamp2-method
#10
Nour Rashwan, Aïssatou Diawara, Marilyn E Scott, Roger K Prichard
BACKGROUND: Diagnosis of soil-transmitted helminths (STHs) has traditionally relied on stool microscopy, which has a number of critical deficiencies. Molecular diagnostics are powerful tools to identify closely related species, but the requirement for costly equipment makes their implementation difficult in low-resource or field settings. Rapid, sensitive and cost-effective diagnostic tools are crucial for accurate estimation of STH infection intensity in MDA programmes in which the goal is to reduce morbidity following repeated rounds of chemotherapy...
October 18, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29047365/the-weight-of-work-the-association-between-maternal-employment-and-overweight-in-low-and-middle-income-countries
#11
Vanessa M Oddo, Sara N Bleich, Keshia M Pollack, Pamela J Surkan, Noel T Mueller, Jessica C Jones-Smith
BACKGROUND: Maternal employment has increased in low-and middle-income countries (LMIC) and is a hypothesized risk factor for maternal overweight due to increased income and behavioral changes related to time allocation. However, few studies have investigated this relationship in LMIC. METHODS: Using cross-sectional samples from Demographic and Health Surveys, we investigated the association between maternal employment and overweight (body mass index [BMI] ≥ 25 kg/m(2)) among women in 38 LMIC (N = 162,768)...
October 18, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29046922/selection-and-identification-of-transferrin-receptor-specific-peptides-as-recognition-probes-for-cancer-cells
#12
Yuyu Tan, Wenli Liu, Zhi Zhu, Lijun Lang, Junxia Wang, Mengjiao Huang, Mingxia Zhang, Chaoyong Yang
Since the transferrin receptor (CD71 or TFRC) is known to be highly expressed in numerous cancers, CD71 has become an attractive target in cancer research. Acquiring specific molecular probes for CD71, such as small molecular ligands, aptamers, peptides, or antibodies, is of great importance for cancer cell recognition and capture. In this work, we chose CD71 as the target for phage display, and after four rounds of positive selection and one round of negative selection, the specific phage library was enriched...
October 18, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29046399/dynamic-localization-of-a-yeast-development-specific-pp1-complex-during-prospore-membrane-formation-is-dependent-on-multiple-localization-signals-and-complex-formation
#13
Tsuyoshi S Nakamura, Yumi Numajiri, Yuuya Okumura, Junji Hidaka, Takayuki Tanaka, Ichiro Inoue, Yasuyuki Suda, Tetsuo Takahashi, Hideki Nakanishi, Xiao-Dong Gao, Aaron M Neiman, Hiroyuki Tachikawa
During the developmental process of sporulation in Saccharomyces cerevisiae, membrane structures called prospore membranes are formed de novo, expand, extend, round up, and finally become plasma membranes of the spores. GIP1 encodes a regulatory/targeting subunit of protein phosphatase type 1 that is required for sporulation. Gip1 recruits the catalytic subunit Glc7 to septin structures that form along the prospore membrane; however, the molecular basis of its localization and function is not fully understood...
October 18, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29046269/what-clinical-information-is-valuable-to-doctors-using-mobile-electronic-medical-records-and-when
#14
Junetae Kim, Yura Lee, Sanghee Lim, Jeong Hoon Kim, Byungtae Lee, Jae-Ho Lee
BACKGROUND: There has been a lack of understanding on what types of specific clinical information are most valuable for doctors to access through mobile-based electronic medical records (m-EMRs) and when they access such information. Furthermore, it has not been clearly discussed why the value of such information is high. OBJECTIVE: The goal of this study was to investigate the types of clinical information that are most valuable to doctors to access through an m-EMR and when such information is accessed...
October 18, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29045981/renal-ewing-s-sarcoma-primitive-neuroectodermal-tumor-a-case-report-and-literature-review
#15
C Liu, L G Cui, H L Wang
Ewing's sarcoma/primitive neuroectodermal tumor (EWS/PNET) in the kidney is a rare but high-grade malignant tumor that affects predominantly elder children and adolescents. Patients mostly present with nonspecific symptoms such as abdominal pain and gross hematuria. Since EWS/PNET has a rapid clinical progression with early metastasis and death, it is essential to make an accurate and early diagnosis. Once diagnosed, multimodality treatment, including radical surgery combined with adjuvant chemotherapy, and radiotherapy if necessary, is recommended...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045673/age-related-changes-in-the-mitochondria-of-human-mural-granulosa-cells
#16
Yifan Liu, Ming Han, Xiaoshuang Li, Hui Wang, Minyue Ma, Shihui Zhang, Yifan Guo, Shuling Wang, Yuanfen Wang, N Duan, Bing Xu, Jingwen Yin, Yuanqing Yao
STUDY QUESTION: What changes in the mitochondria of human mural granulosa cells (mGCs) with maternal aging? SUMMARY ANSWER: The mitochondrial membrane potential (MMP) and the ability of oxidative phosphorylation (OXPHOS) of mGCs declines with reproductive aging, accompanied with more abnormal mitochondria. WHAT IS KNOWN ALREADY: Mitochondria play an important role in the dialogue between the mGCs and oocytes. However, the underlying mechanism of mitochondrial dysfunction in mGCs in aging is still poorly understood...
October 17, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29045651/clinical-decision-support-alert-malfunctions-analysis-and-empirically-derived-taxonomy
#17
Adam Wright, Angela Ai, Joan Ash, Jane F Wiesen, Thu-Trang T Hickman, Skye Aaron, Dustin McEvoy, Shane Borkowsky, Pavithra I Dissanayake, Peter Embi, William Galanter, Jeremy Harper, Steve Z Kassakian, Rachel Ramoni, Richard Schreiber, Anwar Sirajuddin, David W Bates, Dean F Sittig
Objective: To develop an empirically derived taxonomy of clinical decision support (CDS) alert malfunctions. Materials and Methods: We identified CDS alert malfunctions using a mix of qualitative and quantitative methods: (1) site visits with interviews of chief medical informatics officers, CDS developers, clinical leaders, and CDS end users; (2) surveys of chief medical informatics officers; (3) analysis of CDS firing rates; and (4) analysis of CDS overrides. We used a multi-round, manual, iterative card sort to develop a multi-axial, empirically derived taxonomy of CDS malfunctions...
October 16, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29045420/inhibition-of-apoptosis-signal-regulating-kinase-1-alters-the-wound-epidermis-and-enhances-auricular-cartilage-regeneration
#18
Qian-Shi Zhang, Deepa S Kurpad, My G Mahoney, Marla J Steinbeck, Theresa A Freeman
Why regeneration does not occur in mammals remains elusive. In lower vertebrates, epimorphic regeneration of the limb is directed by the wound epidermis, which controls blastema formation to promote regrowth of the appendage. Herein, we report that knockout (KO) or inhibition of Apoptosis Signal-regulated Kinase-1 (ASK1), also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5), after full thickness ear punch in mice prolongs keratinocyte activation within the wound epidermis and promotes regeneration of auricular cartilage...
2017: PloS One
https://www.readbyqxmd.com/read/29045357/clinical-effectiveness-and-cost-of-a-hospital-based-fall-prevention-intervention-the-importance-of-time-nurses-spend-on-the-front-line-of-implementation
#19
Teryl K Nuckols, Jack Needleman, Tristan R Grogan, Li-Jung Liang, Pamela Worobel-Luk, Laura Anderson, Linda Czypinski, Courtney Coles, Catherine M Walsh
OBJECTIVE: The aim of this study is to evaluate the clinical effectiveness and incremental net cost of a fall prevention intervention that involved hourly rounding by RNs at 2 hospitals. BACKGROUND: Minimizing in-hospital falls is a priority, but little is known about the value of fall prevention interventions. METHODS: We used an uncontrolled before-after design to evaluate changes in fall rates and time use by RNs. Using decision-analytical models, we estimated incremental net costs per hospital per year...
October 17, 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29045340/cause-of-renal-infarction-a-retrospective-analysis-of-186-consecutive-cases
#20
Anne-Laure Faucon, Guillaume Bobrie, Anne-Sophie Jannot, Arshid Azarine, Pierre-François Plouin, Michel Azizi, Laurence Amar
BACKGROUND: Renal infarction can cause abrupt and severe hypertension and less frequently renal failure. Renal infarction results from disruption of renal blood flow in the main ipsilateral renal artery or in a segmental branch. Underlying mechanism is either general, 'embolic' or 'thrombophilic', or local related to primary 'renal artery lesion'. It depends on various causes. In absence of an identified cause, renal infarction is classified as 'idiopathic'. Previous studies report a significant number of 'idiopathic' renal infarction...
October 16, 2017: Journal of Hypertension
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