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https://www.readbyqxmd.com/read/29928293/turning-natural-adaptations-to-oncogenic-factors-into-an-ally-in-the-war-against-cancer
#1
Marion Vittecoq, Mathieu Giraudeau, Tuul Sepp, David J Marcogliese, Marcel Klaassen, François Renaud, Beata Ujvari, Frédéric Thomas
Both field and experimental evolution studies have demonstrated that organisms naturally or artificially exposed to environmental oncogenic factors can, sometimes rapidly, evolve specific adaptations to cope with pollutants and their adverse effects on fitness. Although numerous pollutants are mutagenic and carcinogenic, little attention has been given to exploring the extent to which adaptations displayed by organisms living in oncogenic environments could inspire novel cancer treatments, through mimicking the processes allowing these organisms to prevent or limit malignant progression...
July 2018: Evolutionary Applications
https://www.readbyqxmd.com/read/29928122/the-effect-of-evening-primrose-oil-on-fatigue-and-quality-of-life-in-patients-with-multiple-sclerosis
#2
Nastaran Majdinasab, Foroogh Namjoyan, Mohsen Taghizadeh, Hamid Saki
Background: Multiple sclerosis (MS) is a chronic progressive and inflammatory disease of the central nervous system that is characterized by demyelination in the central nervous system. In regard to the prevalence of diseases and enormous costs imposed on society and the health system, finding a way to stop the progression of the disease using drugs with fewer side effects seems a serious sanitation issue to the health of the international community. This study aimed to evaluate the effect of evening primrose oil (EPO) on fatigue and quality of life in patients with MS...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29927045/effects-of-curcumin-and-melatonin-on-bone-formation-in-orthopedically-expanded-suture-in-rats-a-biochemical-histological-and-immunohistochemical-study
#3
M G Cesur, K Gülle, F B Şirin, M Akpolat, G Öğrenim, A Alkan, G Cesur
OBJECTS: To investigate the effects of curcumin (CUR) and melatonin (MEL) on new bone formation following rapid maxillary expansion (RME) in rats. SETTING AND SAMPLE POPULATION: For this study, 24 12-week-old adult male Wistar albino rats from the Animal Laboratory at Adnan Menderes University, Faculty of Medicine, were used. MATERIALS AND METHODS: The rats were randomly divided into the following 3 groups (n = 8 each): only expansion (OE), expansion plus MEL (MEL) and expansion plus CUR (CUR)...
June 21, 2018: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/29926944/periodontal-health-and-gingival-diseases-and-conditions-on-an-intact-and-a-reduced-periodontium-consensus-report-of-workgroup-1-of-the-2017-world-workshop-on-the-classification-of-periodontal-and-peri-implant-diseases-and-conditions
#4
Iain L C Chapple, Brian L Mealey, Thomas E Van Dyke, P Mark Bartold, Henrik Dommisch, Peter Eickholz, Maria L Geisinger, Robert J Genco, Michael Glogauer, Moshe Goldstein, Terrence J Griffin, Palle Holmstrup, Georgia K Johnson, Yvonne Kapila, Niklaus P Lang, Joerg Meyle, Shinya Murakami, Jacqueline Plemons, Giuseppe A Romito, Lior Shapira, Dimitris N Tatakis, Wim Teughels, Leonardo Trombelli, Clemens Walter, Gernot Wimmer, Pinelopi Xenoudi, Hiromasa Yoshie
Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i.e. without clinical attachment loss or bone loss, and on a reduced periodontium in either a non-periodontitis patient (e.g. in patients with some form of gingival recession or following crown lengthening surgery) or in a patient with a history of periodontitis who is currently periodontally stable...
June 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29926684/-effect-of-yuyin-ruangan-granule-on-tgf-%C3%AE-1-expression-in-hepatic-fibrosis-rats
#5
Zhi-Wang Wang, Xiao-Yan Fu, Xiao-Li Cheng, Xiao-Ying Bao, Xue-Feng Liu, Hai-Jing Duan
OBJECTIVES: To observe the preventive and therapeutic action of Yuyin Ruangan Granule (YRG, Traditional Chinese Medicine) in hepatic fibrosis rats model and its effect on transforming growth factor-β1 (TGF-β1) expression. METHODS: The Wistar rats were randomly divided into 6 group ( n =10), and the model of hepatic fibrosis rats was established by subcutaneous injected with carbon tetrachloride (CCL4), fed on high-fat diet and 20% ethanol for 6 weeks, to survey the effect and mechanism of YRG preventing hypatic fibrosis by detecting liver function (the activity of alanine aminotransferase(ALT), aspartate aminotransferase(AST), etc...
February 8, 2018: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/29926499/periodontal-health-and-gingival-diseases-and-conditions-on-an-intact-and-a-reduced-periodontium-consensus-report-of-workgroup-1-of-the-2017-world-workshop-on-the-classification-of-periodontal-and-peri-implant-diseases-and-conditions
#6
Iain L C Chapple, Brian L Mealey, Thomas E Van Dyke, P Mark Bartold, Henrik Dommisch, Peter Eickholz, Maria L Geisinger, Robert J Genco, Michael Glogauer, Moshe Goldstein, Terrence J Griffin, Palle Holmstrup, Georgia K Johnson, Yvonne Kapila, Niklaus P Lang, Joerg Meyle, Shinya Murakami, Jacqueline Plemons, Giuseppe A Romito, Lior Shapira, Dimitris N Tatakis, Wim Teughels, Leonardo Trombelli, Clemens Walter, Gernot Wimmer, Pinelopi Xenoudi, Hiromasa Yoshie
Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i.e. without clinical attachment loss or bone loss, and on a reduced periodontium in either a non-periodontitis patient (e.g. in patients with some form of gingival recession or following crown lengthening surgery) or in a patient with a history of periodontitis who is currently periodontally stable...
June 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29925128/-comparative-study-on-deep-venous-thrombosis-onset-in-hospitalized-patients-with-different-underlying-diseases
#7
M L Sun, X H Wang, J Huang, J Wang, Y Wang
Objective: To improve the understanding of deep venous thrombosis (DVT), the present study was conducted to investigate the difference of DVT onset in hospitalized patients with different underlying diseases. Methods: This is a single-center retrospective study from Beijing Shijitan Hospital. Clinical data from hospital onset DVT patients from 2007 to 2016 were collected. DVT was confirmed with compression ultrasonography (CUS), color Doppler flow imaging (CDFI), CT venography (CTV), magnetic resonance venography (MRV), lower extremities radionuclide venography(RDV) or conventional venography (CV)...
June 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29924312/the-internal-consistency-and-validity-of-the-vaccination-attitudes-examination-scale-a-replication-study
#8
Louise Wood, Michael Smith, Christopher B Miller, Ronan E O'Carroll
Background: Vaccinations are important preventative health behaviors. The recently developed Vaccination Attitudes Examination (VAX) Scale aims to measure the reasons behind refusal/hesitancy regarding vaccinations. Purpose: The aim of this replication study is to conduct an independent test of the newly developed VAX Scale in the UK. We tested (a) internal consistency (Cronbach's α); (b) convergent validity by assessing its relationships with beliefs about medication, medical mistrust, and perceived sensitivity to medicines; and (c) construct validity by testing how well the VAX Scale discriminated between vaccinators and nonvaccinators...
June 19, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29922968/clinical-pharmacist-interventions-in-managing-drug-related-problems-in-hospitalized-patients-with-neurological-diseases
#9
Mostafa A Sayed Ali, Eman Mohamed Hussein Khedr, Fatma Alzahraa Hassan Ahmed, Nada Nasr Eldin Mohamed
Background Drug-related problems (DRPs) are common in hospitalized patients with neurological diseases. Clinical pharmacy services could minimize drug-related harm and improve patient care. Objective To identify common DRPs in neurology and document clinical pharmacists' medication-related interventions. Setting The wards and intensive care unit of the Department of Neurology at Assiut University Hospital. Method Prospective study of clinical pharmacists' interventions during the routine care work of reviewing patients medical charts over a period of 6 months from January to June 2017...
June 19, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29922598/new-application-of-psoralen-and-angelicin-on-periodontitis-with-anti-bacterial-anti-inflammatory-and-osteogenesis-effects
#10
Xiaotian Li, Chunbo Yu, Yi Hu, Xinyi Xia, Yue Liao, Jing Zhang, Huiwen Chen, Weili Lu, Wei Zhou, Zhongchen Song
Psoralen and angelicin are two effective compounds isolated from psoraleae, a traditional Chinese medicine. They have a wide range of applications for bone disease treatment and immune modulation. In this study, we explored their new applications for the treatment of periodontal diseases. This study aimed to investigate the effects of psoralen and angelicin on Porphyromonas gingivalis growth and P. gingivalis -derived lipopolysaccharide (Pg-LPS)-induced inflammation, and further to evaluate their effects on osteogenesis...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29922588/toxic-effects-of-lambda-cyhalothrin-on-the-rat-thyroid-involvement-of-oxidative-stress-and-ameliorative-effect-of-ginger-extract
#11
Wael M Al-Amoudi
Lambda-cyhalothrin (LCT) is a synthetic pyrethroid that is widely used to control insecticide. Ginger is a traditional plant that is widely used as a spice or folk medicine. This study evaluates the antioxidant effect of ginger extract on thyroid toxicity induced by LCT in albino rats. Adult Rats were divided into 4 experimental groups: Group 1: control, Group 2: oral ginger treatment (24 mg/ml, 3 days/week for 4 weeks), Group 3: oral LCT treatment (1/100 LD50 , 3 days/week for 4 weeks), Group 4: oral LCT and ginger mixture treatment...
2018: Toxicology Reports
https://www.readbyqxmd.com/read/29921882/quercetin-attenuates-toosendanin-induced-hepatotoxicity-through-inducing-the-nrf2-gcl-gsh-antioxidant-signaling-pathway
#12
Yao Jin, Zhen-Lin Huang, Li Li, Yang Yang, Chang-Hong Wang, Zheng-Tao Wang, Li-Li Ji
Toosendanin (TSN) is the main active compound in Toosendan Fructus and Meliae Cortex, two commonly used traditional Chinese medicines. TSN has been reported to induce hepatotoxicity, but its mechanism remains unclear. In this study, we demonstrated the critical role of nuclear factor erythroid 2-related factor 2 (Nrf2) in protecting against TSN-induced hepatotoxicity in mice and human normal liver L-02 cells. In mice, administration of TSN (10 mg/kg)-induced acute liver injury evidenced by increased serum alanine/aspartate aminotransferase (ALT/AST) and alkaline phosphatase (ALP) activities, and total bilirubin (TBiL) content as well as the histological changes...
June 19, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29920714/conscientious-objection-and-compromising-the-patient-response-to-hughes
#13
Julian Savulescu, Udo Schuklenk
Hughes offers a consequentialist response to our rejection of accommodation of conscientious objection in medicine. We argue here that his compromise proposition has been tried in many jurisdictions and has failed to deliver unimpeded access to care for eligible patients. The compromise position, entailing an accommodation of conscientious objection provided there is unimpeded access, fails to grasp that the objectors are both determined not to provide services they object to as well as to subvert patient access to the objected to services...
June 19, 2018: Bioethics
https://www.readbyqxmd.com/read/29920452/the-second-annual-think-tank-on-prevention-of-sudden-cardiac-death-in-the-young-developing-a-rational-reliable-and-sustainable-national-health-care-resource-a-report-from-the-cardiac-safety-research-consortium
#14
REVIEW
Peter F Aziz, Stuart Berger, Peter Kowey, Mitchell Krucoff, Martha Lopez-Anderson, Eric Michelson, Silvana Molossi, Valarie Morrow, Ignacio Rodriguez, Tess Elizabeth Saarel, Colette Strnadova, Victoria Vetter, Theressa J Wright, Salim F Idriss
Sudden cardiac death in the young (SCDY) spans gender, race, ethnicity, and socioeconomic class. The loss of any pediatric patient is a matter of national and international public health concern, and focused efforts should be aimed at preventing these burdensome tragedies. Prepared by members of the Cardiac Safety Research Consortium, this White Paper summarizes and reports the dialogue at the second Think Tank related to the issues and the proposed solutions for the development of a national resource for screening and prevention of SCDY...
May 23, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29920356/clitoria-ternatea-l-rootextract-ameliorated-the-cognitive-and-hippocampal-long-term-potentiation-deficits-induced-by-chronic-cerebral-hypoperfusion-in-the-rat
#15
Thenmoly Damodaran, Byorn Wei Liang Tan, Ping Liao, Surash Ramanathan, Lim Gin Keat, Zurina Hassan
ETHNOPHARMACOLOGICAL RELEVANCE: Clitoria ternatea L. (CT), commonly known as Butterfly pea, is used in Indian Ayurvedic medicine to promote brain function and treat mental disorders. Root of CT has been proven to enhance memory, but its role in an animal model of chronic cerebral hypoperfusion (CCH), which has been considered as a major cause of brain disorders, has yet to be explored. AIM OF THE STUDY: To assess the motor and cognitive effects of acute oral administration of CT root methanolic extract and hippocampal long-term plasticity in the CA1 region of the CCH rat model...
June 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29920285/electrochemical-remediation-of-amoxicillin-detoxification-and-reduction-of-antimicrobial-activity
#16
Lara Barroso Brito, Luane Ferreira Garcia, Marcos Pereira Caetano, Germán Sanz Lobón, Mayk Teles de Oliveira, Rhaul de Oliveira, Ieda Maria Sapateiro Torres, Alfonso Yepez, Boniek Gontijo Vaz, Rafael Luque, Cesar Koppe Grisolia, Marize Campos Valadares, Eric de Souza Gil, Gisele Augusto Rodrigues de Oliveira
Amoxicillin (AMX) is one of the most commonly prescribed antibiotics around the world to treat and prevent several diseases in both human and veterinary medicine. Incomplete removal of AMX during wastewater treatment contributes to its presence in water bodies and drinking water. AMX is an emerging contaminant since its impact on the environment and human health remains uncertain. This contribution was aimed to evaluate the electrochemical oxidation (EO) of AMX using different anodes in tap water, NaCl or Na2 SO4 solutions and to evaluate the potential toxicity of remaining AMX and its by-products on zebrafish early-life stages...
June 16, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29916923/probiotics-and-mucositis
#17
Emanuele Cereda, Marilisa Caraccia, Riccardo Caccialanza
PURPOSE OF REVIEW: To provide an updated perspective on the use of probiotics as adjuvant treatment strategy for patients suffering from or at risk of developing mucositis. RECENT FINDINGS: Studies suggest that oral and intestinal microbiota could be relevant to mucositis development and treatment, but no clear high-risk pattern has been identified and no single probiotic formulation has emerged from human clinical trials for strong recommendation. Promising results from available clinical trials suggest their use in patients with peri-implant mucositis or at risk of anticancer treatment-related oral or intestinal mucositis...
June 18, 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29916599/-risk-assessment-and-its-appropriateness-supporting-the-physician-in-the-certification-of-a-suspected-occupational-disease
#18
Giuseppe Taino, Franco Pugliese, Daniela Bonetti, Rossana Astengo, Marcello Imbriani
OBJECTIVES: The topic of appropriateness was defined as the new frontier of development of health interventions. RH Brook in an Editorial published in the BMJ in 1994 defines the appropriateness "… an intervention for which the expected benefits are greater (with a sufficient margin) the possible negative consequences … excluding economic considerations". In workplaces the goal of appropriateness should cover not only the actions of health surveillance and health protocols, but also and primarily all stages of the risk assessment process...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29916593/-the-attention-of-istituto-superiore-di-sanit%C3%A3-to-the-sex-gender-differences-in-workers-health-prevention-and-promotion
#19
Anna Ruggieri, Elisabetta Straface, Eugenio Sorrentino
OBJECTIVES: Gender medicine is a multi-faceted field of investigation integrating various aspects of psycho-social and biological sciences but it mainly deals with the impact of the gender on human physiology, pathophysiology, and clinical features of diseases. In Italy, the Decree Law 81/2008 recently introduced the gender issue in the risk assessment at the workplaces. METHODS: This review briefly describes our current knowledge on gender medicine and on the Italian legislation in risk management...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29916588/-gender-medicine-a-interdisciplinary-approach-to-medicine
#20
Giovannella Baggio
OBJECTIVES: From1995 (Beijing Conference) the World Health Organization strongly did call the attention on the need of great attention to women health and on the lack of studies on the differences in medicine between men and women. From the women health attention we arrived to gender medicine that is a transversal dimension of medicine which describes the differences within the same disease of symptoms, clinical evolution, drug therapy as well as prevention between men and women. METHODS: From some real life examples in this article we wish to make it clear that gender medicine is not a separated medical specialty but a dimension which pass through all specialties...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
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