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https://www.readbyqxmd.com/read/29471324/effectiveness-of-practices-to-support-appropriate-laboratory-test-utilization-a-laboratory-medicine-best-practices-systematic-review-and-meta-analysis
#1
Matthew Rubinstein, Robert Hirsch, Kakali Bandyopadhyay, Bereneice Madison, Thomas Taylor, Anne Ranne, Millie Linville, Keri Donaldson, Felicitas Lacbawan, Nancy Cornish
Objectives: To evaluate the effectiveness of practices used to support appropriate clinical laboratory test utilization. Methods: This review followed the Centers for Disease Control and Prevention (CDC) Laboratory Medicine Best Practices A6 cycle method. Eligible studies assessed one of the following practices for effect on outcomes relating to over- or underutilization: computerized provider order entry (CPOE), clinical decision support systems/tools (CDSS/CDST), education, feedback, test review, reflex testing, laboratory test utilization (LTU) teams, and any combination of these practices...
February 17, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29471086/gastroprotective-effect-of-ethanol-extracts-of-cladodes-and-roots-of-pilosocereus-gounellei-a-weber-ex-k-schum-bly-ex-rowl-cactaceae-on-experimental-ulcer-models
#2
Glaubert A Sousa, Irisdalva S Oliveira, Francilene V Silva-Freitas, Ana Flávia S C Viana, Benedito P S Neto, Francisco Valmor M Cunha, Rodrigo L G Gonçalves, Antônio Carlos M Lima Filho, Maurício P M Amaral, Rita de Cássia M Oliveira, Pedro D Fernandes, Jéssica K S Maciel, Tânia Maria S da Silva, Maria de Fátima V Souza, Francisco A Oliveira
ETHNOPHARMACOLOGICAL RELEVANCE: Pilosocereus gounellei Cactaceae), popularly known as "xique xique", is a species native from Caatinga region of Northeast Brazil, which is used by traditional communities in folk medicine for a variety of health problems, especially inflammatory processes and gastritis. AIM OF THE STUDY: The present study investigates the possible gastric antiulceractivity of ethanol extracts obtained from the cladodes and roots of Pilosocereus gounellei (EECPG and EERPG, respectively) and mechanisms of action underlying this effect...
February 19, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29470968/multiple-sclerosis-mechanisms-and-immunotherapy
#3
REVIEW
Clare Baecher-Allan, Belinda J Kaskow, Howard L Weiner
Multiple sclerosis (MS) is an autoimmune disease triggered by environmental factors that act on a genetically susceptible host. It features three clinical stages: a pre-clinical stage detectable only by MRI; a relapsing-remitting (RRMS) stage characterized by episodes of neurologic dysfunction followed by resolution; and a progressive stage, which usually evolves from the relapsing stage. Advances in our understanding of the immune mechanisms that contribute to MS have led to more than ten FDA-approved immunotherapeutic drugs that target effector T cells, regulatory cells, B cells, and cell trafficking into the nervous system...
February 21, 2018: Neuron
https://www.readbyqxmd.com/read/29470561/safety-and-efficacy-of-cosmetic-augmentation-of-the-nasal-tip-and-nasal-dorsum-with-expanded-polytetrafluoroethylene-a-randomized-clinical-trial
#4
Yifei Gu, Wenxin Yu, Yunbo Jin, Hui Chen, Gang Ma, Shih-Jen Chang, Xiaoxi Lin
Importance: Expanded polytetrafluoroethylene (ePTFE) is a widely used alloplast, but studies of augmentation of the nasal tip and nasal dorsum with ePTFE are lacking. Objective: To investigate whether attaching the conchal cartilage as shield grafts at the distal end of the graft can prevent extrusion and whether the use of ePTFE in the nasal tip can achieve a stable aesthetic outcome. Design, Setting, and Participants: A randomized clinical trial was performed from April 1, 2006, to October 31, 2008...
February 22, 2018: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29470395/therapeutic-potential-of-oridonin-and-its-analogs-from-anticancer-and-antiinflammation-to-neuroprotection
#5
REVIEW
Jimin Xu, Eric A Wold, Ye Ding, Qiang Shen, Jia Zhou
Oridonin, a diterpenoid natural product commonly used in East Asian herbal medicine, is garnering increased attention in the biomedical community due to its extensive biological activities that include antitumor, anti-inflammatory, antimicrobial, hepatic fibrosis prevention, and neurological effects. Over the past decade, significant progress has been made in structure activity relationship and mechanism of action studies of oridonin for the treatment of cancer and other diseases. This review provides a brief summary on oridonin and its analogs in cancer drug discovery and antiinflammation and highlights its emerging therapeutic potential in neuroprotection applications...
February 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29469464/-investigation-and-morphological-observation-of-histiostoma-feroniarum-breeding-in-chinese-herbal-medicine-rhizoma-zingiberis
#6
Chai Qiang, Guo Jiao-Jiao, Tao Ning, Li Chao-Pin
OBJECTIVE: To understand the breeding situation of Histiostoma feroniarum in Chinese herbal medicine Rhizoma Zingiberis. METHODS: The Rhizoma Zingiberis sold on the market was selected and brushed. The dust from Rhizoma Zingiberis was screened under a microscope to search the mites. The mites were made into specimens to identify the species. RESULTS: The mites were H. feroniarum . Totally 14 mites were found in 100 g dust sample, with the density of breeding of 0...
March 21, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29469463/-carpoglyphus-lactis-infestation-in-stored-traditional-chinese-medicine-arillus-longan
#7
Hong Yong, Chai Qiang, Zhan Xiao-Dong, Li Chao-Pin
OBJECTIVE: To investigate the breeding of Carpoglyphus lactis in the storage Arillus longan , so as to provide the evidence for preventing the harm of C. lactis to traditional Chinese medicine. METHODS: Chinese herbal medicine warehouses were chosen as survey sites according to the breeding habits of mites, and the A. longan samples were stored more than 6 months. The mites were isolated and identified under a microscope. RESULTS: The C. lactis breeding rate was 20...
July 27, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29469336/-analysis-of-academic-impact-of-publications-from-national-institute-of-parasitic-diseases-chinese-center-for-disease-control-and-prevention-based-on-scie-database-in-recent-five-years
#8
Li Zhen, Zheng Bin
OBJECTIVE: To describe the academic impact of publications from National Institute of Parasitic Diseases (NIPD), Chinese Center for Disease Control and Prevention, so as to give the quantity evidence for scientific research decision making. METHODS: The SCIE papers of NIPD published from 2011-2015 were searched and statistically analyzed. The number of published papers, citation frequencies, h-index, and funding resources were analyzed. The academic impact of the institute was assessed according to these data...
March 2, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29469240/actual-versus-expected-doses-of-half-tablets-containing-prescribed-psychoactive-substances-a-systematic-review
#9
Jaqueline K Eserian, Márcia Lombardo, Jair R Chagas, José C F Galduróz
Objective: To assess through a systematic review of the literature if the practice of splitting tablets containing psychoactive/psychotropic medications for medical or economic reasons would result in the expected doses. Data Sources: A MEDLINE and PsycInfo comprehensive search of English-language publications from January 1999 to December 2015 was conducted using the terms describing tablet splitting (tablet splitting, split tablets, tablet subdivision, divided tablets, and half tablets) and psychoactive substances (psychoactive medicines, psychotropic medicines, antidepressants, anxiolytics, anticonvulsants, antipsychotics, and antiparkinsonian agents)...
February 8, 2018: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/29468851/isolates-from-alpinia-officinarum-hance-attenuate-lps-induced-inflammation-in-hepg2-evidence-from-in-silico-and-in-vitro-studies
#10
Abdullah A Elgazar, Nabil M Selim, Nabil M Abdel-Hamid, Mohammed A El-Magd, Hala M El Hefnawy
In an attempt to connect the legacy of centuries of invaluable knowledge from traditional medicine and the current understanding to the molecular mechanism of diseases, we took the advantage of the emergence of in silico screening as a promising tool for identification of potential leads from libraries of natural products. Traditional Chinese Medicine database was subjected to structure based virtual screening for identification of anti-inflammatory compounds using the 3D crystal structure of p38 alpha mitogen activated protein kinase...
February 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29467119/pre-exposure-prophylaxis-youtube-videos-content-evaluation
#11
Aleksandar Kecojevic, Corey Basch, Charles Basch, William Kernan
BACKGROUND: Antiretroviral (ARV) medicines reduce the risk of transmitting the HIV virus and are recommended as daily pre-exposure prophylaxis (PrEP) in combination with safer sex practices for HIV-negative individuals at a high risk for infection, but are underused in HIV prevention. Previous literature suggests that YouTube is extensively used to share health information. While pre-exposure prophylaxis (PrEP) is a novel and promising approach to HIV prevention, there is limited understanding of YouTube videos as a source of information on PrEP...
February 16, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29466987/antioxidant-capacities-and-total-phenolic-contents-of-20-polyherbal-remedies-used-as-tonics-by-folk-healers-in-phatthalung-and-songkhla-provinces-thailand
#12
Wipawee Chanthasri, Nuntitporn Puangkeaw, Nongluk Kunworarath, Patcharawalai Jaisamut, Surasak Limsuwan, Katesarin Maneenoon, Piyapong Choochana, Sasitorn Chusri
BACKGROUND: Uses of polyherbal formulations have played a major role in traditional medicine. The present study is focused on the formulations used in traditional Thai folkloric medicine as tonics or bracers. Twenty documented polyherbal mixtures, used as nourishing tonics by the folk healers in Phatthalung and Songkhla provinces in southern Thailand, are targeted. Despite traditional health claims, there is no scientific evidence to support the utilization of polyherbal formulations...
February 21, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29466560/comparison-of-military-and-civilian-methods-for-determining-potentially-preventable-deaths-a-systematic-review
#13
Jud C Janak, Jonathan A Sosnov, Joan M Bares, Zsolt T Stockinger, Harold R Montgomery, Russ S Kotwal, Frank K Butler, Stacy A Shackelford, Jennifer M Gurney, Mary Ann Spott, Louis N Finelli, Edward L Mazuchowski, David J Smith
Importance: Military and civilian trauma experts initiated a collaborative effort to develop an integrated learning trauma system to reduce preventable morbidity and mortality. Because the Department of Defense does not currently have recommended guidelines and standard operating procedures to perform military preventable death reviews in a consistent manner, these performance improvement processes must be developed. Objectives: To compare military and civilian preventable death determination methods to understand the existing best practices for evaluating preventable death...
February 21, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29465807/revisiting-polyarenes-and-related-molecules-an-update-of-synthetic-approaches-and-structure-activity-mechanistic-correlation-for-carcinogenesis
#14
REVIEW
Dinabandhu Sar, Benjamin Kim, Fatemeh Ostadhossein, Santosh K Misra, Dipanjan Pan
A major proportion of basic cause for human cancer has been linked to widespread environmental pollutants including analogs of polyarenes. Search of an effective therapy can be started with the understanding of the generation of such "carcinogens" and their biological interactions. This review is to discuss the syntheses, structural activities, mechanistic and biological studies of polyarenes such as polycyclic aromatic hydrocarbons (PAHs), polycyclic azaarenes (PAAs) and their thia-analogs (PASH)...
February 21, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29465664/knowledge-practices-and-barriers-to-hiv-pre-exposure-prophylaxis-prep-prescribing-among-washington-state-medical-providers
#15
Brian R Wood, Vanessa M McMahan, Kelly Naismith, Jonathan B Stockton, Lori A Delaney, Joanne D Stekler
BACKGROUND: We aimed to assess HIV pre-exposure prophylaxis (PrEP) awareness and prescribing practices among Washington State medical providers from diverse professional disciplines and practice types. METHODS: In May 2016, we administered an anonymous online survey to licensed medical practitioners who provide primary, longitudinal, walk-in, emergency, obstetric, gynecologic, sexually transmitted infection (STI), or family planning care. RESULTS: Of 735 eligible providers, 64...
January 4, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29464385/prevention-of-emergence-agitation-with-ketamine-in-rhinoplasty
#16
Canser Yilmaz Demir, Nureddin Yuzkat
BACKGROUND: Emergence agitation (EA), defined as restlessness, disorientation, excitation, and/or inconsolable crying, is a common phenomenon during early recovery from general anesthesia. In this study, we aimed to determine the (1) EA incidence after rhinoplasty operations in adults; (2) the effects of ketamine administered at sub-anesthetic doses just 20 min before the end of the surgery in rhinoplasty operations on agitation level, postoperative pain, side effects, and complications; and (3) to determine the risk factors for EA in adults after rhinoplasty...
February 20, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29464356/weighing-the-anti-ischemic-benefits-and-bleeding-risks-from-aspirin-therapy-a-rational-approach
#17
REVIEW
Sagar Dugani, Jeffrey M Ames, JoAnn E Manson, Samia Mora
PURPOSE OF REVIEW: The role of aspirin in secondary cardiovascular prevention is well understood; however, the role in primary prevention is less clear, and requires careful balancing of potential benefits with risks. Here, we summarize the evidence base on the benefits and risks of aspirin therapy, discuss clinical practice guidelines and decision support tools to assist in initiating aspirin therapy, and highlight ongoing trials that may clarify the role of aspirin in cardiovascular disease prevention...
February 21, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29464084/lysine-specific-demethylase-1-inhibitors-prevent-teratoma-development-from-human-induced-pluripotent-stem-cells
#18
Naoki Osada, Jiro Kikuchi, Takashi Umehara, Shin Sato, Masashi Urabe, Tomoyuki Abe, Nakanobu Hayashi, Masahiko Sugitani, Yutaka Hanazono, Yusuke Furukawa
Human induced pluripotent stem cells (hiPSCs) are creating great expectations for regenerative medicine. However, safety strategies must be put in place to guard against teratoma formation after transplantation of hiPSC-derived cells into patients. Recent studies indicate that epigenetic regulators act at the initial step of tumorigenesis. Using gain-of-function and loss-of-function approaches, we show here that the expression and function of lysine-specific demethylase 1 (LSD1) are tightly regulated in hiPSCs, and their deregulation underlies the development of teratomas...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29463490/motivational-interviewing-and-medication-review-in-coronary-heart-disease-mimeric-protocol-for-a-randomized-controlled-trial-investigating-effects-on-clinical-outcomes-adherence-and-quality-of-life
#19
Malin Johansson Östbring, Tommy Eriksson, Göran Petersson, Lina Hellström
BACKGROUND: Preventive treatment goals for blood pressure and cholesterol levels continue to be unmet for many coronary patients. The effect of drug treatment depends on both its appropriateness and the patients' adherence to the treatment regimen. There is a need for adherence interventions that have a measurable effect on clinical outcomes. OBJECTIVE: This study aims to evaluate the effects on treatment goals of an intervention designed to improve patient adherence and treatment quality in secondary prevention of coronary heart disease...
February 20, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29463334/the-role-of-oral-health-in-complex-emergencies-and-disaster-rehabilitation-medicine
#20
Vishal R Aggarwal
This paper presents an overview of the importance of oral health in complex emergencies. It highlights the importance of maintaining general and oral health in the acute, intermediate and long-term phases of such events which are increasing in frequency. The importance of oral health as an early warning sign for systemic disease and deprivation is also explored along with the crucial role of oral health in maintaining quality of life through adequate nutrition and speech. The overview of oral health in these situations identifies the need for training dental personnel as members of rehabilitation teams that set out to manage these disasters...
February 21, 2018: Disaster Medicine and Public Health Preparedness
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