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https://www.readbyqxmd.com/read/28633193/trictide-a-tricellulin-derived-peptide-to-overcome-cellular-barriers
#1
Jimmi Cording, Basak Arslan, Christian Staat, Sophie Dithmer, Susanne M Krug, Anneliese Krüger, Philipp Berndt, Ramona Günther, Lars Winkler, Ingolf E Blasig, Reiner F Haseloff
The majority of tight junction (TJ) proteins restrict the paracellular permeation of solutes via their extracellular loops (ECLs). Tricellulin tightens tricellular TJs (tTJs) and regulates bicellular TJ (bTJ) proteins. We demonstrate that the addition of recombinantly produced extracellular loop 2 (ECL2) of tricellulin opens cellular barriers. The peptidomimetic trictide, a synthetic peptide derived from tricellulin ECL2, increases the passage of ions, as well as of small and larger molecules up to 10 kDa, between 16 and 30 h after application to human epithelial colorectal adenocarcinoma cell line 2...
June 20, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28617871/hypoxia-inducible-factor-1%C3%AE-plays-roles-in-epstein-barr-virus-s-natural-life-cycle-and-tumorigenesis-by-inducing-lytic-infection-through-direct-binding-to-the-immediate-early-bzlf1-gene-promoter
#2
Richard J Kraus, Xianming Yu, Blue-Leaf A Cordes, Saraniya Sathiamoorthi, Tawin Iempridee, Dhananjay M Nawandar, Shidong Ma, James C Romero-Masters, Kyle G McChesney, Zhen Lin, Kathleen R Makielski, Denis L Lee, Paul F Lambert, Eric C Johannsen, Shannon C Kenney, Janet E Mertz
When confronted with poor oxygenation, cells adapt by activating survival signaling pathways, including the oxygen-sensitive transcriptional regulators called hypoxia-inducible factor alphas (HIF-αs). We report here that HIF-1α also regulates the life cycle of Epstein-Barr virus (EBV). Incubation of EBV-positive gastric carcinoma AGS-Akata and SNU-719 and Burkitt lymphoma Sal and KemIII cell lines with a prolyl hydroxylase inhibitor, L-mimosine or deferoxamine, or the NEDDylation inhibitor MLN4924 promoted rapid and sustained accumulation of both HIF-1α and lytic EBV antigens...
June 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28559020/establishment-and-characterization-of-a-clear-cell-odontogenic-carcinoma-cell-line-with-ewsr1-atf1-fusion-gene
#3
Satoko Kujiraoka, Takaaki Tsunematsu, Yukiko Sato, Maki Yoshida, Ayataka Ishikawa, Rei Tohyama, Michio Tanaka, Yutaka Kobayashi, Tomoyuki Kondo, Aya Ushio, Kunihiro Otsuka, Mie Kurosawa, Masako Saito, Akiko Yamada, Rieko Arakaki, Hirokazu Nagai, Hiromasa Nikai, Kengo Takeuchi, Toshitaka Nagao, Youji Miyamoto, Naozumi Ishimaru, Yasusei Kudo
OBJECTIVE: Clear cell odontogenic carcinoma (CCOC) is a rare malignant odontogenic tumor (MOT) characterized by sheets and lobules of vacuolated and clear cells. To understand the biology of CCOC, we established a new cell line, CCOC-T, with EWSR1-ATF1 fusion gene from a mandible tumor with distant metastasis and characterized this cell line. MATERIALS AND METHODS: To detect the EWSR1-ATF1 fusion gene, we used three CCOC cases, including the present case, by RT-PCR and FISH analysis...
June 2017: Oral Oncology
https://www.readbyqxmd.com/read/28552016/syringoid-eccrine-carcinoma-of-the-foot-report-of-a-rare-cutaneous-adnexal-neoplasm
#4
Woo Cheal Cho, Brian Wagner, Melissa Gulosh, Zendee Elaba
Syringoid eccrine carcinoma is a rare malignant adnexal tumor that typically presents in the head and neck region. Involvement of the extremities is uncommon, with only a few cases reported in the literature. Here, we report our experience with a rare case of syringoid eccrine carcinoma occurring on the plantar surface of the right foot in a 47-year-old African American woman. Histologically, incisional biopsy revealed a tumor consisting of tubulocystic structures lined by basaloid cells with an infiltrative growth pattern, extending from the reticular dermis to the deep biopsy margin...
May 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27812087/identifying-early-target-cells-of-nipah-virus-infection-in-syrian-hamsters
#5
Laura Baseler, Dana P Scott, Greg Saturday, Eva Horne, Rebecca Rosenke, Tina Thomas, Kimberly Meade-White, Elaine Haddock, Heinz Feldmann, Emmie de Wit
BACKGROUND: Nipah virus causes respiratory and neurologic disease with case fatality rates up to 100% in individual outbreaks. End stage lesions have been described in the respiratory and nervous systems, vasculature and often lymphoid organs in fatal human cases; however, the initial target organs of Nipah virus infection have not been identified. Here, we detected the initial target tissues and cells of Nipah virus and tracked virus dissemination during the early phase of infection in Syrian hamsters inoculated with a Nipah virus isolate from Malaysia (NiV-M) or Bangladesh (NiV-B)...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27717203/anterior-regeneration-after-fission-in-the-holothurian-cladolabes-schmeltzii-dendrochirotida-holothuroidea
#6
Yaroslav O Kamenev, Igor Y Dolmatov
The regeneration of the anterior portion of the body after fission was studied in the holothurian Cladolabes schmeltzii using electron microscopy methods. Following fission, the posterior portion of the digestive tube, cloaca, and respiratory trees remain in the posterior fragment of the body. The regeneration comprises five stages. In the first stage, connective-tissue thickening (an anlage of the aquapharyngeal bulb) occurs on the anterior end between the torn-off ends of the ambulacra. Most of the lost anterior organs developed in the second and third stages...
February 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/27516009/explants-isolated-human-placenta-and-umbilical-cord-cells-share-characteristics-of-both-epithelial-and-mesenchymal-stem-cells
#7
Diana Maria Anastasiu, Ada Cean, Maria Florina Bojin, Adrian Gluhovschi, Carmen Panaitescu, Virgil Păunescu, Gabriela Tănăsie
In recent years, identification of new sources of adult stem cells developed rapidly, pursuing to find easily available tissues, which will give rise to homogenous stem cells populations. Up to present, bone marrow-derived mesenchymal stem cells (BM-MSCs) are unanimously considered to fulfill the criteria for being used in clinical settings, but adipose stem cells, placental and umbilical cord stem cells, and other tissue-derived stem cells are making their way to being used at least in autologous transplantation...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27281503/administration-of-h2-blockers-in-nsaid-induced-gastropathy-in-rats-effect-on-histopathological-changes-in-gastric-hepatic-and-renal-tissues
#8
Sachin Manocha, Dushyant Lal, Subramanian Venkataraman
BACKGROUND: Nonsteroidal anti-inflammatory drugs induces gastric mucosal lesions because of its acidic properties. Ranitidine, an H2 receptor antagonist, has proved beneficial in patients with gastric ulcers. OBJECTIVE: The present study was performed to assess the effect of administering ranitidine in Nonsteroidal anti-inflammatory drugs (diclofenac, nimesulide) induced gastropathy, and their effect on the histopathology of stomach, kidney and liver. METHODS: Diclofenac, nimesulide, and ranitidine were administered in doses of 2, 4, and 6 mg/kg, p...
January 2016: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/27008339/polydimethylsiloxane-pdms-modulates-cd38-expression-absorbs-retinoic-acid-and-may-perturb-retinoid-signalling
#9
Kathryn Futrega, Jianshi Yu, Jace W Jones, Maureen A Kane, William B Lott, Kerry Atkinson, Michael R Doran
Polydimethylsiloxane (PDMS) is the most commonly used material in the manufacture of customized cell culture devices. While there is concern that uncured PDMS oligomers may leach into culture medium and/or hydrophobic molecules may be absorbed into PDMS structures, there is no consensus on how or if PDMS influences cell behaviour. We observed that human umbilical cord blood (CB)-derived CD34(+) cells expanded in standard culture medium on PDMS exhibit reduced CD38 surface expression, relative to cells cultured on tissue culture polystyrene (TCP)...
April 21, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/26984710/morpho-histology-of-head-kidney-of-female-catfish-heteropneustes-fossilis-seasonal-variations-in-melano-macrophage-centers-melanin-contents-and-effects-of-lipopolysaccharide-and-dexamethasone-on-melanins
#10
Ravi Kumar, K P Joy, S M Singh
In the catfish Heteropneustes fossilis, the anterior kidney is a hemopoietic tissue which surrounds the adrenal homologues, interrenal (IR) and chromaffin tissues corresponding to the adrenal cortical and adrenal medulla of higher mammals. The IR tissue is arranged in cell cords around the posterior cardinal vein (PCV) and its tributaries and secretes corticosteroids. The chromaffin tissue is scattered singly or in nests of one or more cells around the epithelial lining of the PCV or blood capillaries within the IR tissue...
October 2016: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/26887384/the-critical-role-of-srpk1-in-emt-of-human-glioblastoma-in-the-spinal-cord
#11
Zhengbu Liao, Jing Wu, Mingjun Wu, Yi Yan, Haiquan Wang, Chongjie Cheng, Wenyuan Tang
Up to now, the serine-arginine protein kinase 1 (SRPK1) has been suggested as an important signal mediator, which is implicated in the development of cancers. Unfortunately, some molecular pathways in SRPK1-mediated epithelial-mesenchymal transition (EMT) in human spinal glioblastoma have been not elucidated. In this work, we detected the expression of SRPK1 in human spinal glioblastoma tissues and GBM cell lines and analyzed the relevant molecular proteins using in vitro experiments, including RT-PCR, gene silencing, and Western blot...
April 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/26792842/the-spinal-ependymal-layer-in-health-and-disease
#12
S A Moore
Ependymal cells are epithelial support cells that line the central canal and ventricular cavities of the central nervous system, providing the interface between the cerebrospinal fluid and the parenchyma of the brain and spinal cord. The spinal ependymal layer (SEL) is composed of 3 main cell types: tanycytes, ependymocytes, and cerebrospinal fluid-contacting neurons. A fourth cell type, termed the supraependymal cell, is also occasionally described. Cells of the SEL show restricted proliferative capacity in health but display neural stem cell properties both in vitro and in vivo in various disease states...
July 2016: Veterinary Pathology
https://www.readbyqxmd.com/read/26763198/rescue-hf-trial-retrograde-delivery-of-allogeneic-umbilical-cord-lining-sub-epithelial-cells-in-patients-with-heart-failure
#13
Jorge Tuma, Antonio Carrasco, Jorge Castillo, Carlos Cruz, Alvaro Carrillo, Jose Ercilla, Carlos Yarleque, Jaime Cunza, Courtney E Bartlett, Amalia A Winters, Francisco J Silva, Amit N Patel
BACKGROUND: Cell therapy is an evolving option for patients with end stage heart failure. First generation cell therapy trials have had marginal success. Our goal was to evaluate retrograde delivery of allogeneic umbilical cord sub-epithelial cells (UCSEC) in patients with heart failure. METHODS: A prospective open label dose escalation study of the safety and feasibility of UCSEC infused retrograde into the coronary sinus was performed. Patients received a single dose of either 100 million (M), 200M or 400M cells...
January 13, 2016: Cell Transplantation
https://www.readbyqxmd.com/read/26689265/multidimensional-genome-wide-analyses-show-accurate-fviii-integration-by-zfn-in-primary-human-cells
#14
Jaichandran Sivalingam, Dimitar Kenanov, Hao Han, Ajit Johnson Nirmal, Wai Har Ng, Sze Sing Lee, Jeyakumar Masilamani, Toan Thang Phan, Sebastian Maurer-Stroh, Oi Lian Kon
Costly coagulation factor VIII (FVIII) replacement therapy is a barrier to optimal clinical management of hemophilia A. Therapy using FVIII-secreting autologous primary cells is potentially efficacious and more affordable. Zinc finger nucleases (ZFN) mediate transgene integration into the AAVS1 locus but comprehensive evaluation of off-target genome effects is currently lacking. In light of serious adverse effects in clinical trials which employed genome-integrating viral vectors, this study evaluated potential genotoxicity of ZFN-mediated transgenesis using different techniques...
March 2016: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/26560358/aav-gene-transfer-delays-disease-onset-in-a-tpp1-deficient-canine-model-of-the-late-infantile-form-of-batten-disease
#15
Martin L Katz, Luis Tecedor, Yonghong Chen, Baye G Williamson, Elena Lysenko, Fred A Wininger, Whitney M Young, Gayle C Johnson, Rebecca E H Whiting, Joan R Coates, Beverly L Davidson
The most common form of the childhood neurodegenerative disease late infantile neuronal ceroid lipofuscinosis (also called Batten disease) is caused by deficiency of the soluble lysosomal enzyme tripeptidyl peptidase 1 (TPP1) resulting from mutations in the TPP1 gene. We tested whether TPP1 gene transfer to the ependyma, the epithelial lining of the brain ventricular system, in TPP1-deficient dogs would be therapeutically beneficial. A one-time administration of recombinant adeno-associated virus (rAAV) expressing canine TPP1 (rAAV...
November 11, 2015: Science Translational Medicine
https://www.readbyqxmd.com/read/26454200/stem-cell-therapies-in-the-treatment-of-diabetic-retinopathy-and-keratopathy
#16
REVIEW
Andrei A Kramerov, Alexander V Ljubimov
Nonproliferative diabetic retinopathy (DR) is characterized by multiple degenerative changes that could be potentially corrected by stem cell therapies. Most studies so far have attempted to alleviate typical abnormalities of early retinopathy, including vascular hyperpermeability, capillary closure and pericyte dropout. Success was reported with adult stem cells (vascular progenitors or adipose stem cells), as well as induced pluripotent stem cells from cord blood. The cells were able to associate with damaged vessels in both pericyte and endothelial lining positions in models of DR and ischemia-reperfusion...
March 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/26207305/human-umbilical-cord-lining-cells-as-novel-feeder-layer-for-ex-vivo-cultivation-of-limbal-epithelial-cells
#17
Leonard Pek-Kiang Ang, Preeti Jain, Toan Thang Phan, Hasan Mahmud Reza
PURPOSE: To determine the effectiveness of human umbilical cord-derived mucin-expressing cord lining epithelial cells (CLEC-muc) as feeder cells in a coculture system for the cultivation of human limbal stem cells. METHODS: Human CLEC-muc were cultured in PTTe-1 medium and treated with mitomycin C to arrest their growth to make the feeder layer. Single-cell suspension of limbal cells was prepared from corneal rim collected from the Singapore Eye Bank. Limbal cells were cultured in a coculture system with CLEC-muc as well as 3T3 cells as feeder layer...
July 2015: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26151310/umbilical-cord-derived-mesenchymal-stem-cells-promote-proliferation-and-migration-in-mcf-7-and-mda-mb-231-breast-cancer-cells-through-activation-of-the-erk-pathway
#18
Tao Li, Chunfu Zhang, Yanling Ding, Wei Zhai, Kui Liu, Fan Bu, Tao Tu, Lingxian Sun, Wei Zhu, Fangfang Zhou, Wenkai Qi, Jiabo Hu, Huabiao Chen, Xiaochun Sun
Mesenchymal stem cells (MSCs) are known to migrate to tumor tissues and to play an important role in cancer progression. However, the effects of MSCs on tumor progression remain controversial. The purpose of the present study was to detect the effects of human umbilical cord-derived MSCs (hUC‑MSCs) on the human breast cancer cell lines MDA-MB‑231 and MCF-7 in vitro and the underlying mechanisms. MSCs were isolated and identified from umbilical cord tissues. MDA-MB‑231 and MCF-7 cells were treated with conditioned medium (CM) from 10 and 20% umbilical cord MSCs (UC-MSCs), and the resulting changes in proliferation and migration were investigated...
September 2015: Oncology Reports
https://www.readbyqxmd.com/read/26116019/paradental-cyst-is-an-inclusion-cyst-of-the-junctional-sulcular-epithelium-of-the-gingiva-histopathologic-and-immunohistochemical-confirmation-for-its-pathogenesis
#19
Satoshi Maruyama, Manabu Yamazaki, Tatsuya Abé, Hamzah Babkair, Jun Cheng, Takashi Saku
OBJECTIVE: The aim of this study was to characterize the histologic and immunohistochemical profiles of paradental cyst-lining epithelia to clarify its histopathogenesis. STUDY DESIGN: Ten surgical specimens of paradental cysts were examined for clinical profiles and to determine the histopathologic characteristics of the lining epithelia. Immunohistochemical profiles for keratin (K) subtypes, as well as for perlecan, UEA-I lectin binding, and proliferating cell nuclear antigen (PCNA), were determined and compared...
August 2015: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/26093883/spatiotemporal-expression-of-rhomboid-domain-containing-2-rhbdd2-during-rat-development
#20
V A Ferretti, R Canzoneri, C G Barbeito, M V Croce, M C Abba, E Lacunza
Over the last few years rhomboid genes have gained interest because of its association with cancer and neurodegenerative diseases. In previous studies, we demonstrated that human RHBDD2 is over-expressed in the advanced stages of breast and colorectal cancers, suggesting a favorable role in cell proliferation. So far little is known about the expression of RHBDD2 in other tissues and other species, and because of similarities between cancer and embryonic cells, this study focused on the evaluation of Rhbdd2 expression in embryonic and adult rat tissues...
September 2015: Acta Histochemica
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