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umbilical cord stem cells

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https://www.readbyqxmd.com/read/29916543/differentiation-of-umbilical-cord-mesenchymal-stem-cells-into-hepatocytes-in-comparison-with-bone-marrow-mesenchymal-stem-cells
#1
Ya-Bin Yu, Yan Song, Ya Chen, Feng Zhang, Fu-Zhen Qi
Mesenchymal stem cells (MSCs) are considered to be an ideal source for the cell therapy of end‑stage liver diseases. Umbilical cord (UC)‑MSCs can be obtained via a non‑invasive procedure and can be easily cultured, making them potentially superior candidates for cell transplantation when compared with MSCs from other sources. In the present study, UC‑MSCs were induced to differentiate into hepatocytes and were compared with bone marrow (BM)‑MSCs for their hepatic differentiation potential. UC‑MSCs showed significantly higher proliferation than BM‑MSCs...
June 18, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29914060/translational-regenerative-therapies-for-chronic-spinal-cord-injury
#2
REVIEW
Kyriakos Dalamagkas, Magdalini Tsintou, Amelia Seifalian, Alexander M Seifalian
Spinal cord injury is a chronic and debilitating neurological condition that is currently being managed symptomatically with no real therapeutic strategies available. Even though there is no consensus on the best time to start interventions, the chronic phase is definitely the most stable target in order to determine whether a therapy can effectively restore neurological function. The advancements of nanoscience and stem cell technology, combined with the powerful, novel neuroimaging modalities that have arisen can now accelerate the path of promising novel therapeutic strategies from bench to bedside...
June 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29909688/single-factor-sox2-mediates-direct-neural-reprogramming-of-human-mesenchymal-stem-cells-via-transfection-of-in-vitro-transcribed-mrna
#3
Bo-Eun Kim, Soon Won Choi, Ji-Hee Shin, Jae-Jun Kim, Insung Kang, Byung-Chul Lee, Jin Young Lee, Myoung Geun Kook, Kyung-Sun Kang
Neural stem cells (NSCs) are a prominent cell source for understanding neural pathogenesis and for developing therapeutic applications to treat neurodegenerative disease because of their regenerative capacity and multipotency. Recently, a variety of cellular reprogramming technologies have been developed to facilitate in vitro generation of NSCs, called induced NSCs (iNSCs). However, the genetic safety aspects of established virus-based reprogramming methods have been considered, and non-integrating reprogramming methods have been developed...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29908640/comparative-study-of-regenerative-effects-of-mesenchymal-stem-cells-derived-from-placental-amnion-chorion-and-umbilical-cord-on-dermal-wounds
#4
Juliane Ertl, Melanie Pichlsberger, Alexandru-Cristian Tuca, Paul Wurzer, Jakob Fuchs, Stefan H Geyer, Barbara Maurer-Gesek, Wolfgang J Weninger, Dagmar Pfeiffer, Vladimir Bubalo, Daryousch Parvizi, Lars-Peter Kamolz, Ingrid Lang
OBJECTIVE: Mesenchymal stem/stromal cells derived from human term placentas (PMSCs) are novel therapeutic agents and more topical than ever. Here we evaluated the effects of three types of PMSCs on wound healing in an in vivo mouse model: Amnion-derived MSCs (AMSCs), blood vessel-derived MSCs (BV-MSCs) from the chorionic plate and Wharton's jelly-derived MSCs (WJ-MSCs) from the umbilical cord. METHODS: We topically applied PMSCs onto skin wounds in mice using the dermal substitute Matriderm® as carrier and evaluated wound healing parameters...
May 2018: Placenta
https://www.readbyqxmd.com/read/29905411/anti-inflammatory-and-antioxidant-effects-of-mesenchymal-and-hematopoietic-stem-cells-in-a-rheumatoid-arthritis-rat-model
#5
Hanan Abdelmawgoud, Asmaa Saleh
BACKGROUND: Mesenchymal stem cells (MSCs) are of increased importance because of their capacity to counteract inflammation and suppress host immune responses. OBJECTIVES: The aim of the study was to compare the effectiveness of MSCs and hematopoietic stem cells (HSCs) in the treatment of rheumatoid arthritis (RA). MATERIAL AND METHODS: Paw swelling was assessed by measuring the thickness of the hind paws using a caliper. Cytokines - interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta (TGF-β), and IL-10 - and rheumatoid factor (RF) were measured using enzyme-linked immunosorbent assay (ELISA) kits...
June 15, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29905067/surface-functionalization-of-polymeric-nanoparticles-with-umbilical-cord-derived-mesenchymal-stem-cell-membrane-for-tumor-targeted-therapy
#6
Na Yang, Yanping Ding, Yinlong Zhang, Bin Wang, Xiao Zhao, Keman Cheng, Yixin Huang, Mohammad Taleb, Jing Zhao, Wen-Fei Dong, Lirong Zhang, Guangjun Nie
Multiple cell plasma membranes have been utilized for surface functionalization of synthetic nanomaterials and construction of biomimetic drug delivery systems for cancer treatment. The natural characters and facile isolation of original cells facilitate the biomedical applications of plasma membranes in functionalizing nanocarriers. Human umbilical cord-derived mesenchymal stem cells (MSC) have been identified to show tropism towards malignant lesions and have great advantages in ease of acquisition, low immunogenicity, and high proliferative ability...
June 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29899571/the-safety-and-efficacy-of-clofarabine-in-combination-with-high-dose-cytarabine-and-total-body-irradiation-myeloablative-conditioning-and-allogeneic-stem-cell-transplantation-in-children-adolescents-and-young-adults-caya-with-poor-risk-acute-leukemia
#7
Jessica Hochberg, Stacey Zahler, Mark B Geyer, Nan Chen, Jennifer Krajewski, Lauren Harrison, Olga Militano, M Fevzi Ozkaynak, Alexandra C Cheerva, Julie Talano, Theodore B Moore, Alfred P Gillio, Mark C Walters, Lee Ann Baxter-Lowe, Carl Hamby, Mitchell S Cairo
Acute leukemias in children with CR3, refractory relapse, or induction failure (IF) have a poor prognosis. Clofarabine has single agent activity in relapsed leukemia and synergy with cytarabine. We sought to determine the safety and overall survival in a Phase I/II trial of conditioning with clofarabine (doses 40 - 52 mg/m2 ), cytarabine 1000 mg/m2 , and 1200 cGy TBI followed by alloSCT in children, adolescents, and young adults with poor-risk leukemia. Thirty-seven patients; Age 12 years (1-22 years); ALL/AML: 34:3 (18 IF, 10 CR3, 13 refractory relapse); 15 related, 22 unrelated donors...
June 13, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29895317/hypoxia-with-wharton-s-jelly-mesenchymal-stem-cell-coculture-maintains-stemness-of-umbilical-cord-blood-derived-cd34-cells
#8
Dewan Zhao, Lingjia Liu, Qiang Chen, Fangfang Wang, Qiuyang Li, Qiang Zeng, Jingcao Huang, Maowen Luo, Wenxian Li, Yuhuan Zheng, Ting Liu
BACKGROUND: The physiological approach suggests that an environment associating mesenchymal stromal cells with low O2 concentration would be most favorable for the maintenance of hematopoietic stem/progenitor cells (HSPCs). To test this hypothesis, we performed a coculture of cord blood CD34+ cells with Wharton's jelly mesenchymal stem cells (WJ-MSCs) under different O2 concentration to simulate the growth of HSPCs in vivo, and assessed the impacts on stemness maintenance and proliferation of cord blood HSPCs in vitro...
June 13, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29892282/mis416-enhances-therapeutic-functions-of-human-umbilical-cord-blood-derived-mesenchymal-stem-cells-against-experimental-colitis-by-modulating-systemic-immune-milieu
#9
Byung-Chul Lee, Nari Shin, Jin Young Lee, Insung Kang, Jae-Jun Kim, Seung Eun Lee, Soon Won Choi, Gill A Webster, Kyung-Sun Kang
Human adult stem cells, including umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs), have recently been considered a promising alternative treatment for inflammatory bowel disease (IBD) due to their unique immunomodulatory properties and ability to promote tissue regeneration. However, despite many years of research and pre-clinical studies, results from clinical trials using these cells have been diverse and conflicting. This discrepancy is caused by several factors, such as poor engraftment, low survival rate, and donor-dependent variation of the cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29892279/introduction-of-human-flt3-l-and-gm-csf-into-humanized-mice-enhances-the-reconstitution-and-maturation-of-myeloid-dendritic-cells-and-the-development-of-foxp3-cd4-t-cells
#10
Ryutaro Iwabuchi, Shota Ikeno, Mie Kobayashi-Ishihara, Haruko Takeyama, Manabu Ato, Yasuko Tsunetsugu-Yokota, Kazutaka Terahara
Two cytokines, fms-related tyrosine kinase 3 ligand (Flt3-L) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are considered to be the essential regulators of dendritic cell (DC) development in vivo . However, the combined effect of Flt3-L and GM-CSF on human DCs has not been evaluated in vivo . In this study, we, therefore, aimed at evaluating this using a humanized mouse model. Humanized non-obese diabetic/SCID/Jak3null (hNOJ) mice were constructed by transplanting hematopoietic stem cells from human umbilical cord blood into newborn NOJ mice, and in vivo transfection (IVT) was performed by hydrodynamic injection-mediated gene delivery using plasmids encoding human Flt3-L and GM-CSF...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29880606/transient-inhibition-of-nf-%C3%AE%C2%BAb-signaling-enhances-ex-vivo-propagation-of-human-hematopoietic-stem-cells
#11
Mehrnaz Safaee Talkhoncheh, Agatheeswaran Subramaniam, Mattias Magnusson, Praveen Kumar, Jonas Larsson, Aurélie Baudet
Despite extensive studies, it has been challenging to define culture conditions in which hematopoietic stem cells (HSCs) can be expanded ex vivo. Here, we show that chemical inhibition of the NF-κB signaling pathway leads to a significant improvement of HSC function from ex vivo cultured human umbilical cord blood derived CD34+ cells. We found a distinct peak of activation of the NF-κB pathway shortly after cells were put in culture, and consequently inhibition of the pathway was both necessary and sufficient during the first 24 hours of culture where it reduced the levels of several pro-inflammatory cytokines...
June 7, 2018: Haematologica
https://www.readbyqxmd.com/read/29875586/human-umbilical-cord-derived-mesenchymal-stem-cells-reduce-monosodium-iodoacetate-induced-apoptosis-in-cartilage
#12
Yu-Hsun Chang, Kun-Chi Wu, Hwan-Wun Liu, Tang-Yuan Chu, Dah-Ching Ding
Objective: The present study investigated the therapeutic potential and underlying mechanisms of human umbilical cord mesenchymal stem cells (HUCMSCs) on joint cartilage destruction induced by monosodium iodoacetate (MIA) in mice. Materials and Methods: HUCMSCs were tested for mesenchymal stem cell (MSC) characteristics including surface markers by flow cytometry and mesoderm differentiation (adipogenesis, osteogenesis, and chondrogenesis). Terminal deoxynucleotidyl transferase dUTP nick end labeling assay and Western blot assay were used to evaluate MIA-induced chondrocyte apoptosis...
April 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29871514/significant-improvement-of-acute-complete-spinal-cord-injury-patients-diagnosed-by-a-combined-criteria-implanted-with-neuroregen-scaffolds-and-mesenchymal-stem-cells
#13
Zhifeng Xiao, Fengwu Tang, Yannan Zhao, Guang Han, Na Yin, Xing Li, Bing Chen, Sufang Han, Xianfeng Jiang, Chen Yun, Changyu Zhao, Shixiang Cheng, Sai Zhang, Jianwu Dai
Stem cells and biomaterials transplantation hold a promising treatment for functional recovery in spinal cord injury (SCI) animal models. However, the functional recovery of complete SCI patients was still a huge challenge in clinic. Additionally, there is no clinical standard procedure available to diagnose precisely an acute patient as complete SCI. Here, two acute SCI patients, with injury at thoracic 11 (T11) and cervical 4 (C4) level respectively, were judged as complete injury by a stricter method combined with American Spinal Injury Association (ASIA) Impairment Scale, magnetic resonance imaging (MRI) and nerve electrophysiology...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29867527/the-reparative-abilities-of-menstrual-stem-cells-modulate-the-wound-matrix-signals-and-improve-cutaneous-regeneration
#14
Jimena Cuenca, Alice Le-Gatt, Valentina Castillo, Jose Belletti, Macarena Díaz, Mónica Kurte G, Paz L Gonzalez, Francisca Alcayaga-Miranda, Christina M A P Schuh, Fernando Ezquer, Marcelo Ezquer, Maroun Khoury
Considerable advances have been made toward understanding the cellular and molecular mechanism of wound healing, however, treatments for chronic wounds remain elusive. Emerging concepts utilizing mesenchymal stem cells (MSCs) from umbilical cord, adipose tissue and bone marrow have shown therapeutical advantages for wound healing. Based on this positive outcome, efforts to determine the optimal sources for MSCs are required in order to improve their migratory, angiogenic, immunomodulatory, and reparative abilities...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29861743/treatment-of-full-thickness-rotator-cuff-tendon-tear-using-umbilical-cord-blood-derived-mesenchymal-stem-cells-and-polydeoxyribonucleotides-in-a-rabbit-model
#15
Dong Rak Kwon, Gi-Young Park, Sang Chul Lee
Objective: The aim of this study was to investigate regenerative effects of ultrasound- (US-) guided injection with human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) and/or polydeoxyribonucleotide (PDRN) injection in a chronic traumatic full-thickness rotator cuff tendon tear (FTRCTT) in a rabbit model. Methods: Rabbits ( n = 32) were allocated into 4 groups. After a 5 mm sized FTRCTT just proximal to the insertion site on the subscapularis tendon was created by excision, the wound was immediately covered by a silicone tube to prevent natural healing...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29861739/evaluation-of-the-curative-effect-of-umbilical-cord-mesenchymal-stem-cell-therapy-for-knee-arthritis-in-dogs-using-imaging-technology
#16
Bei-Ying Zhang, Bing-Yun Wang, Shao-Chuan Li, Dong-Zhang Luo, Xiaoshu Zhan, Sheng-Feng Chen, Zhi-Sheng Chen, Can-Ying Liu, Hui-Qin Ji, Yin-Shan Bai, Dong-Sheng Li, Yang He
Objective: The aim of this study was to assess the efficacy of canine umbilical cord mesenchymal stem cells (UC-MSCs) on the treatment of knee osteoarthritis in dogs. Methods: Eight dogs were evenly assigned to two groups. The canine model of knee osteoarthritis was established by surgical manipulation of knee articular cartilage on these eight dogs. UC-MSCs were isolated from umbilical cord Wharton's jelly by 0.1% type collagenase I and identified by immunofluorescence staining and adipogenic and osteogenic differentiation in vitro ...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29859169/spotlight-on-glycolysis-a-new-target-for-cord-blood-expansion
#17
Andrea M Patterson, Louis M Pelus
Umbilical cord blood (UCB) is a highly valuable but low-quantity source of hematopoietic stem cells (HSCs) for life-saving transplantations. Recently in Nature Medicine, Guo et al. (2018) found that antagonism of a glycolysis-blocking pathway enhances ex vivo expansion of long-term HSCs from human UCB.
June 1, 2018: Cell Stem Cell
https://www.readbyqxmd.com/read/29848167/exosomes-derived-from-bone-mesenchymal-stem-cells-repair-traumatic-spinal-cord-injury-via-suppressing-the-activation-of-a1-neurotoxic-reactive-astrocytes
#18
Wei Liu, Yongxiang Wang, Fangyi Gong, Yuluo Rong, Yongjun Luo, Pengyu Tang, Zheng Zhou, Zhimin Zhou, Tao Xu, Tao Jiang, Siting Yang, Guoyong Yin, Jian Chen, Jin Fan, Weihua Cai
Mesenchymal stem cell (MSC) transplantation is now considered as an effective treatment strategy for traumatic spinal cord injury (SCI). However, several key issues remain unresolved, including low survival rates, cell dedifferentiation, and tumor formation. Recent studies have demonstrated that the therapeutic effect of transplanted stem cells is primarily paracrine-mediated. Exosomes are an important paracrine factor that can be used as a direct therapeutic agent. However, there are few reports on the application of exosomes derived from bone MSCs (BMSCs-Exos) in treating SCI...
May 31, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29845511/umbilical-cord-mesenchymal-stem-cells-conditioned-medium-promotes-a%C3%AE-25-35-phagocytosis-by-modulating-autophagy-and-a%C3%AE-degrading-enzymes-in-bv2-cells
#19
Zhihao Xu, Wenbin Nan, Xiaoyue Zhang, Yuliang Sun, Jichao Yang, Kecheng Lu, Yalin Liu, Yaoxin Gao, Fen Yang, Wenchao Mao, Xuekun Xing, Jiang Du, Han Li, Yonghai Li, Huigen Feng, Zhiqing Yuan, Juntang Lin
Mesenchymal stem cell (MSC) therapy is a promising prospect for the treatment of Alzheimer's disease (AD); however, the underlying mechanisms by which MSCs mediate positive effects are still unclear. We speculated that MSCs mediate microglial autophagy and enhance the clearance of Aβ. To test this hypothesis, we cultured BV2 microglial cells with umbilical cord mesenchymal stem cells conditioned medium (ucMSCs-CM) in the presence or absence of Aβ25-35 oligomers. We investigated BV2 cell proliferation, cell death, and Aβ25-35 phagocytosis as well as protein expression levels of LC3, Beclin-1, p62, insulin-degrading enzyme (IDE), and neprilysin (Nep) with western blotting...
May 29, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29843192/cd73-cd90-cd105-and-cadherin-11-rt-pcr-screening-for-mesenchymal-stem-cells-from-cryopreserved-human-cord-tissue
#20
Hung Pham, Richard Tonai, Miya Wu, Chiara Birtolo, Monica Chen
Background and Objectives: Mesenchymal stem cells (MSCs) are self-renewing, non-specialized cells used clinically in tissue regeneration and sourced from bone marrow, peripheral blood, umbilical cord blood and umbilical cord tissue (UCT). To demonstrate an alternative method for MSC detection, cryopreserved UCT and expanded MSC were screened for MSC markers CD73, CD90, CD105 and CDH-11 by RT-PCR. Methods and Results: Human UCT were washed, sectioned, cryopreserved with 10% DMSO and stored in the vapor phase of liquid nitrogen...
May 30, 2018: International Journal of Stem Cells
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