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umbilical cord stem cells

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https://www.readbyqxmd.com/read/29238069/kynurenic-acid-an-ido-metabolite-controls-tsg-6-mediated-immunosuppression-of-human-mesenchymal-stem-cells
#1
Guan Wang, Kai Cao, Keli Liu, Yueqing Xue, Arthur I Roberts, Fengying Li, Yanyan Han, Arnold B Rabson, Ying Wang, Yufang Shi
Mesenchymal stem cells (MSCs) have been demonstrated to be anti-inflammatory against various immune disorders through several factors, including indoleamine 2,3-dioxygenase (IDO) and TNF-stimulated gene 6 (TSG-6). However, little is known about the necessity for both of these key immunosuppressive factors. Here we employed the mouse lipopolysaccharide (LPS)-induced acute lung injury (ALI) model, and found that IDO is necessary to achieve the effect of human umbilical cord-derived MSC (hUC-MSC)-based treatment on ALI...
December 13, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29235254/mesenchymal-stem-cells-a-double-edged-sword-in-radiation-induced-lung-injury
#2
Yi Yao, Zhongliang Zheng, Qibin Song
Radiation therapy is an important treatment modality for multiple thoracic malignancies. However, radiation-induced lung injury (RILI), which is the term generally used to describe damage to the lungs caused by exposure to ionizing radiation, remains a critical issue affecting both tumor control and patient quality of life. Despite tremendous effort, there is no current consensus regarding the optimal treatment approach for RILI. Because of a number of functional advantages, including self-proliferation, multi-differentiation, injury foci chemotaxis, anti-inflammation, and immunomodulation, mesenchymal stem cells (MSCs) have been a focus of research for many years...
December 13, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/29223366/therapeutic-efficacy-and-safety-of-umbilical-cord-mesenchymal-stem-cell-transplantation-for-liver-cirrhosis-in-chinese-population-a-meta-analysis
#3
Weiwei Sang, Benji Lv, Ke Li, Yan Lu
BACKGROUND AND OBJECTIVE: Mesenchymal stem cells transfusion has been considered as a promising option for liver cirrhosis (LC). The aim of this study was to systematically evaluate the efficacy and safety of umbilical cord mesenchymal stem cells (UMSC) combined with traditional supportive therapy (TST) for the treatment of patients with LC. METHODS: Data was extracted from clinical trials published on Web of Science, PubMed, EMBASE, Cochrane Library, Wanfang and CNKI database...
December 6, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29219174/igfbp3-deposited-in-the-human-umbilical-cord-mesenchymal-stem-cell-secreted-extracellular-matrix-promotes-bone-formation
#4
Moyuan Deng, Keyu Luo, Tianyong Hou, Fei Luo, Zhao Xie, Zehua Zhang, Aijun Yang, Bo Yu, Shaoxuan Yi, Tan Jiulin, Shiwu Dong, Jianzhong Xu
The extracellular matrix (ECM) contains rich biological cues for cell recruitment, proliferation and even differentiation. The osteoinductive potential of scaffolds could be enhanced through human bone marrow mesenchymal stem cell (hBMSC) directly depositing extracellular matrix (ECM) on surface of scaffolds. However, the role and mechanism of human umbilical cord MSC-secreted ECM in bone formation remain unknown. We tested the osteoinductive properties of a human umbilical cord MSC-secreted ECM construct (hUCMSC-ECM) in a large femur defect of a severe combined immunodeficiency mouse model...
December 8, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29210653/human-umbilical-cord-mesenchymal-stem-cells-subpopulations-and-their-difference-in-cell-biology-and-effects-on-retinal-degeneration-in-rcs-rats
#5
L Wang, P Li, Y Tian, Z Li, C Lian, Q Ou, C Jin, F Gao, J-Y Xu, J Wang, F Wang, J Zhang, J Zhang, W Li, H Tian, L Lu, G-T Xu
Human umbilical cord mesenchymal stem cells (hUC-MSCs) are potential candidates for treating retinal degeneration (RD). To further study the biology and therapeutic effects of these cells, two hUC-MSC subpopulations, termed hUC-MSC1 and hUC-MSC2, were isolated by single-cell cloning method and their therapeutic functions were compared in RCS rat, a RD model. Although both subsets satisfied the basic requirements for hUC-MSCs, they were significantly different in morphology, proliferation rate, differentiation capacity, phenotype and gene expression...
December 5, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/29209609/culture-medium-supplements-derived-from-human-platelet-and-plasma-cell-commitment-and-proliferation-support
#6
Anita Muraglia, Van Thi Nguyen, Marta Nardini, Massimo Mogni, Domenico Coviello, Beatrice Dozin, Paolo Strada, Ilaria Baldelli, Matteo Formica, Ranieri Cancedda, Maddalena Mastrogiacomo
Present cell culture medium supplements, in most cases based on animal sera, are not fully satisfactory especially for the in vitro expansion of cells intended for human cell therapy. This paper refers to (i) an heparin-free human platelet lysate (PL) devoid of serum or plasma components (v-PL) and (ii) an heparin-free human serum derived from plasma devoid of PL components (Pl-s) and to their use as single components or in combination in primary or cell line cultures. Human mesenchymal stem cells (MSC) primary cultures were obtained from adipose tissue, bone marrow, and umbilical cord...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29209319/mesenchymal-stem-cells-induce-expression-of-cd73-in-human-monocytes-in-vitro-and-in-a-swine-model-of-myocardial-infarction-in-vivo
#7
Marta Monguió-Tortajada, Santiago Roura, Carolina Gálvez-Montón, Marcella Franquesa, Antoni Bayes-Genis, Francesc E Borràs
The ectoenzymes CD39 and CD73 regulate the purinergic signaling through the hydrolysis of adenosine triphosphate (ATP)/ADP to AMP and to adenosine (Ado), respectively. This shifts the pro-inflammatory milieu induced by extracellular ATP to the anti-inflammatory regulation by Ado. Mesenchymal stem cells (MSCs) have potent immunomodulatory capabilities, including monocyte modulation toward an anti-inflammatory phenotype aiding tissue repair. In vitro, we observed that human cardiac adipose tissue-derived MSCs (cATMSCs) and umbilical cord MSCs similarly polarize monocytes toward a regulatory M2 phenotype, which maintained the expression of CD39 and induced expression of CD73 in a cell contact dependent fashion, correlating with increased functional activity...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29205089/altered-bioenergetics-profile-in-umbilical-cord-and-amniotic-mesenchymal-stem-cells-from-newborns-of-obese-women
#8
Laura Iaffaldano, Carmela Nardelli, Francesca D'Alessio, Valeria D'Argenio, Marcella Nunziato, Lucia Mauriello, Claudio Procaccini, Giuseppe Maria Maruotti, Pasquale Martinelli, Giuseppe Matarese, Lucio Pastore, Luigi Del Vecchio, Giuseppe Labruna, Lucia Sacchetti
Nutritional imbalance and metabolic alterations associated with maternal obesity during pregnancy predispose offspring to obesity and/or to type 2 diabetes, but the mechanisms underlying these effects are still obscure. In this context, we evaluated whether the two main energy-producing pathways (glycolysis and mitochondrial oxidative phosphorylation) are impaired in obesity during pregnancy thus contributing to metabolic intrauterine alterations. Specifically, we studied metabolic abnormalities in the intrauterine life of newborns using stem cells isolated from amnion and umbilical cord (hA- and hUC-MSCs)...
December 5, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/29204746/comparative-analysis-of-human-wharton-s-jelly-mesenchymal-stem-cells-derived-from-different-parts-of-the-same-umbilical-cord
#9
Dinesh Bharti, Sharath Belame Shivakumar, Ji-Kwon Park, Imran Ullah, Raghavendra Baregundi Subbarao, Ji-Sung Park, Sung-Lim Lee, Bong-Wook Park, Gyu-Jin Rho
Easy isolation, lack of ethical issues, high proliferation, multi-lineage differentiation potential and immunomodulatory properties of umbilical cord (UC)-derived mesenchymal stem cells (MSCs) make them a valuable tool in stem cell research. Recently, Wharton's jelly (WJ) was proven as the best MSC source among various compartments of UC. However, it is still unclear whether or not Wharton's jelly-derived MSCs (WJMSCs) from different parts of the whole cord exhibit the same characteristics. There may be varied MSCs present in different parts of WJ throughout the length of the UC...
December 4, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29200953/effects-of-osteogenic-conditioned-medium-from-human-periosteum-derived-cells-on-osteoclast-differentiation
#10
Hyun-Chang Park, Young-Bum Son, Sung-Lim Lee, Gyu-Jin Rho, Young-Hoon Kang, Bong-Wook Park, Sung-Hoon Byun, Sun-Chul Hwang, In-Ae Cho, Yeong-Cheol Cho, Iel-Yong Sung, Dong Kyun Woo, June-Ho Byun
Stem/progenitor cell-based regenerative medicine using the osteoblast differentiation of mesenchymal stem cells (MSCs) is regarded as a promising approach for the therapeutic treatment of various bone defects. The effects of the osteogenic differentiation of stem/progenitor cells on osteoclast differentiation may have important implications for use in therapy. However, there is little data regarding the expression of osteoclastogenic proteins during osteoblastic differentiation of human periosteum-derived cells (hPDCs) and whether factors expressed during this process can modulate osteoclastogenesis...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29194667/evaluation-of-the-impact-of-banking-umbilical-cord-blood-units-with-high-cell-dose-for-ethnically-diverse-patients
#11
Gretta Stritesky, Kimberly Wadsworth, Merry Duffy, Kelly Buck, Jason Dehn
BACKGROUND: Umbilical cord blood units provide an important stem cell source for transplantation, particularly for patients of ethnic diversity who may not have suitably matched available, adult-unrelated donors. However, with the cost of cord blood unit acquisition from public banks significantly higher than that for adult-unrelated donors, attention is focused on decreasing cost yet still providing cord blood units to patients in need. Historical practices of banking units with low total nucleated cell counts, including units with approximately 90 × 107 total nucleated cells, indicates that most banked cord blood units have much lower total nucleated cell counts than are required for transplant...
December 1, 2017: Transfusion
https://www.readbyqxmd.com/read/29189387/ex-vivo-expanded-natural-killer-cells-derived-from-long-term-cryopreserved-cord-blood-are-cytotoxic-against-primary-breast-cancer-cells
#12
Tina Nham, Sophie M Poznanski, Isabella Y Fan, Fatemeh Vahedi, Mira M Shenouda, Amanda J Lee, Marianne V Chew, Richard T Hogg, Dean A Lee, Ali A Ashkar
With over 600,000 units of umbilical cord blood (CB) stored on a global scale, it is important to elucidate the therapeutic abilities of this cryopreserved reservoir. In the advancing field of natural killer (NK) cell cancer immunotherapy, CB has proven to be a promising and noninvasive source of therapeutic NK cells. Although studies have proven the clinical efficacy of using long-term cryopreserved CB in the context of hematopoietic stem cell transplantations, little is known about its use for the ex vivo expansion of effector immune cells...
November 17, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29187247/improvement-of-renal-function-after-human-umbilical-cord-mesenchymal-stem-cell-treatment-on-chronic-renal-failure-and-thoracic-spinal-cord-entrapment-a-case-report
#13
Ahmad Jabir Rahyussalim, Ifran Saleh, Tri Kurniawati, Andi Praja Wira Yudha Lutfi
BACKGROUND: Chronic renal failure is an important clinical problem with significant socioeconomic impact worldwide. Thoracic spinal cord entrapment induced by a metabolic yield deposit in patients with renal failure results in intrusion of nervous tissue and consequently loss of motor and sensory function. Human umbilical cord mesenchymal stem cells are immune naïve and they are able to differentiate into other phenotypes, including the neural lineage. Over the past decade, advances in the field of regenerative medicine allowed development of cell therapies suitable for kidney repair...
November 30, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29186705/mesenchymal-stem-cell-treatment-prevents-post-stroke-dysregulation-of-matrix-metalloproteinases-and-tissue-inhibitors-of-metalloproteinases
#14
Bharath Chelluboina, Koteswara Rao Nalamolu, Gustavo G Mendez, Jeffrey D Klopfenstein, David M Pinson, David Z Wang, Krishna Kumar Veeravalli
BACKGROUND/AIMS: Stem cell treatment is one of the potential treatment options for ischemic stroke. We recently demonstrated a protective effect of human umbilical cord blood-derived mesenchymal stem cells (HUCB-MSCs) in a rat model of ischemic stroke. The treatment attenuated apoptosis and prevented DNA damage. A collection of published studies, including several from our laboratory, indicated the induction and detrimental role for several matrix metalloproteinases (MMPs) in post-stroke brain injury...
November 30, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29185401/improvement-in-therapeutic-ability-of-wharton-s-jelly-derived-mesenchymal-stem-cells-with-vitamin-e-in-breast-cancer
#15
Nadia Wajid, Muhammad Azam, Seemab Khalid, Fatima Ali, Aamer Qazi, M H Qazi
OBJECTIVE: To assess the role of Vitamin E to improve the survival of Wharton's jelly derived mesenchymal stem cells (WJMSCs) in breast cancer conditions. STUDY DESIGN: An experimental study. PLACE AND DURATION OF STUDY: Centre for Research in Molecular Medicine, University of Lahore, from November 2016 to March 2017. METHODOLOGY: WJMSCs were obtained from umbilical cord tissue with enzyme digestion method. Isolated cells were characterized for CD90 and CD45 by immunocytochemistry...
December 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29179738/laser-modified-titanium-surfaces-enhance-the-osteogenic-differentiation-of-human-mesenchymal-stem-cells
#16
Tatiana A B Bressel, Jana Dara Freires de Queiroz, Susana Margarida Gomes Moreira, Jéssyca T da Fonseca, Edson A Filho, Antônio Carlos Guastaldi, Silvia Regina Batistuzzo de Medeiros
BACKGROUND: Titanium surfaces have been modified by various approaches with the aim of improving the stimulation of osseointegration. Laser beam (Yb-YAG) treatment is a controllable and flexible approach to modifying surfaces. It creates a complex surface topography with micro and nano-scaled patterns, and an oxide layer that can improve the osseointegration of implants, increasing their usefulness as bone implant materials. METHODS: Laser beam irradiation at various fluences (132, 210, or 235 J/cm2) was used to treat commercially pure titanium discs to create complex surface topographies...
November 28, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29178564/a-pilot-study-of-mesenchymal-stem-cell-therapy-for-acute-liver-allograft-rejection
#17
Ming Shi, Zhenwen Liu, Ying Wang, Rounan Xu, Yanling Sun, Min Zhang, Xi Yu, Hongbo Wang, Lingzhan Meng, Haibin Su, Lei Jin, Fu-Sheng Wang
Acute allograft rejection remains common after liver transplantation despite modern immunosuppressive agents. In addition, the long-term side effects of these regimens, including opportunistic infections, are challenging. This study evaluated the safety and clinical feasibility of umbilical cord-derived mesenchymal stem cell (UC-MSC) therapy in liver transplant patients with acute graft rejection. Twenty-seven liver allograft recipients with acute rejection were randomly assigned into the UC-MSC infusion group or the control group...
December 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29178199/hematopoietic-niche-exploring-biomimetic-cues-to-improve-the-functionality-of-hematopoietic-stem-progenitor-cells
#18
REVIEW
Marta H G Costa, António M de Soure, Joaquim M S Cabral, Frederico Castelo Ferreira, Cláudia L da Silva
The adult bone marrow (BM) niche is a complex entity where a homeostatic hematopoietic system is maintained through a dynamic crosstalk between different cellular and non-cellular players. Signaling mechanisms triggered by cell-cell, cell-extracellular matrix (ECM), cell-cytokine interactions and local microenvironment parameters are involved in controlling quiescence, self-renewal, differentiation and migration of hematopoietic stem/progenitor cells (HSPC). A promising strategy to more efficiently expand HSPC numbers and tune their properties ex-vivo is to mimic the hematopoietic niche through integration of adjuvant stromal cells, soluble cues and/or biomaterial-based approaches in HSPC culture systems...
November 27, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29175461/the-future-of-mesenchymal-stem-cell-based-therapeutic-approaches-for-cancer-from-cells-to-ghosts
#19
Andrea Mohr, Ralf Zwacka
Mesenchymal stem cells (MSCs) are multipotent stromal cells which can differentiate into a variety of cell types including osteoblasts, adipocytes and chondrocytes. They are normally resident in adipose tissue, bone marrow and the umbilical cord, but can also be found in other tissues and are known to be recruited to sites of wound healing as well as growing tumours. The therapeutic potential of MSCs has been explored in a number of phase I/II and III clinical trials, of which several were targeted against graft-versus-host disease and to support engraftment of haematopoietic stem cells (HSCs), but currently only very few in the oncology field...
November 23, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29175152/transplantation-of-human-umbilical-cord-blood-mononuclear-cells-attenuated-ischemic-injury-in-mcao-rats-via-inhibition-of-nf-%C3%AE%C2%BAb-andnlrp3inflammasome
#20
Lu Liu, Juan Cen, Yong Man, Jianbin Li, Dahuan Zhang, Fei Wang, Jinhua Li, Ji Ma, Xiaoming Wang, Biansheng Ji
Accumulated evidences displayed that transplantation of stem cells may be a promising approach for the treatment of neurological disorders. However, the underlying mechanisms remain to be well elucidated. Moreover, some investigators can not reproduce similar results as the previous. The present results showed that transplantation of fresh human umbilical cord blood mononuclear cells (cbMNCs) attenuated ischemic damage in middle cerebral artery occlusion (MCAO) rats, accompanied with improvement of neurologic deficits, learning and memory function...
November 23, 2017: Neuroscience
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