keyword
https://read.qxmd.com/read/38531221/endothelial-clec-1b-plays-a-protective-role-against-cancer-hematogenous-metastasis
#1
JOURNAL ARTICLE
Ekura Yamazaki, Koji Ikeda, Ryota Urata, Daisuke Ueno, Akiko Katayama, Fumiaki Ito, Hiroshi Ikegaya, Satoaki Matoba
Metastasis, which is the spread of cancer cells into distant organs, is a critical determinant of prognosis in patients with cancer, and blood vessels are the major route for cancer cells to spread systemically. Extravasation is a critical process for the hematogenous metastasis; however, its underlying molecular mechanisms remain poorly understood. Here, we identified that senescent ECs highly express C-type lectin domain family 1 member B (CLEC-1b), and that endothelial CLEC-1b inhibits the hematogenous metastasis of a certain type of cancer...
March 22, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38527187/secondary-sites-of-the-c-type-lectin-like-fold
#2
JOURNAL ARTICLE
Jonathan Lefebre, Torben Falk, Yunzhan Ning, Christoph Rademacher
C-type lectins are a large superfamily of proteins involved in a multitude of biological processes. In particular, their involvement in immunity and homeostasis has rendered them attractive targets for diverse therapeutic interventions. They share a characteristic C-type lectin-like domain whose adaptability enables them to bind a broad spectrum of ligands beyond the originally defined canonical Ca2+-dependent carbohydrate binding. Together with variable domain architecture and high-level conformational plasticity, this enables C-type lectins to meet diverse functional demands...
March 25, 2024: Chemistry: a European Journal
https://read.qxmd.com/read/38513961/dynamics-of-cuticle-associated-transcript-profiles-during-moulting-of-the-bed-bug-cimexlectularius
#3
JOURNAL ARTICLE
Justin Flaven-Pouchon, Christin Froschauer, Bernard Moussian
The bed bug Cimex lectularius is a worldwide human pest. The sequenced genome allows molecular analyses of all aspects of bed bug biology. The present work was conducted to contribute to bed bug cuticle biology. As in other insect species, the C. lectularius cuticle consists of the three horizontal layers procuticle, epicuticle and envelope. To analyse the genes needed for the establishment of the stratified cuticle, we studied the expression pattern of 42 key cuticle-related genes at the transition of the penultimate nymphal stage to adult animals when a new cuticle is formed...
March 19, 2024: Insect Biochemistry and Molecular Biology
https://read.qxmd.com/read/38509909/c-type-lectin-2d-clec2d-is-upregulated-in-clear-cell-renal-cell-carcinoma-ccrcc-tissues-and-predicts-poor-prognosis
#4
JOURNAL ARTICLE
Huibing Li, Pengyi Zheng, Zhijun Li, Qingjiang Han, Bisheng Zhou, Kaixuan Wang
Clear cell renal cell carcinoma (ccRCC) is known as the most common type of renal cancer. Recently, a series of advances have been made in targeted therapy for ccRCC. To combat this highly metastatic tumor, novel therapeutic targets still need to be developed. C-type lectins (CLECs) contain a characteristic C-type lectin-like domain and affect several physiological functions. The effects of C-type lectin 2D (CLEC2D) on cancer progression have been revealed in several types of cancers; however, its expression in ccRCC tissues, and the possible effects on the progression and metastasis of ccRCC, are still unclear...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38504248/c-type-lectin-like-receptor-2-roles-and-drug-target
#5
REVIEW
Lan Sun, Zhe Wang, Zhiyan Liu, Guangyan Mu, Yimin Cui, Qian Xiang
C-type lectin-like receptor-2 (CLEC-2) is a member of the C-type lectin superfamily of cell surface receptors. The first confirmed endogenous and exogenous ligands of CLEC-2 are podoplanin and rhodocytin, respectively. CLEC-2 is expressed on the surface of platelets, which participates in platelet activation and aggregation by binding with its ligands. CLEC-2 and its ligands are involved in pathophysiological processes, such as atherosclerosis, cancer, inflammatory thrombus status, maintenance of vascular wall integrity, and cancer-related thrombosis...
March 19, 2024: Thrombosis Journal
https://read.qxmd.com/read/38359177/a-role-of-platelet-c-type-lectin-like-receptor-2-and-its-ligand-podoplanin-in-vascular-biology
#6
JOURNAL ARTICLE
Katsue Suzuki-Inoue, Nagaharu Tsukiji
PURPOSE OF REVIEW: Platelets are essential for hemostasis and are also vital in lymphatic and lung development and the maintenance of vascular integrity. Platelet activation receptor C-type lectin-like receptor 2 (CLEC-2) and its endogenous ligand podoplanin (PDPN) in lymphatic endothelial cells (LECs) and other cells regulate these processes. This review aims to comprehensively summarize the roles of platelet CLEC-2 and PDPN. This review also focuses on discussing the underlying mechanisms by which platelet CLEC-2 and PDPN mediate blood/lymphatic separation...
February 7, 2024: Current Opinion in Hematology
https://read.qxmd.com/read/38353642/clec-1-restrains-acute-inflammatory-response-and-recruitment-of-neutrophils-following-tissue-injury
#7
JOURNAL ARTICLE
Camille Ligeron, Javier Saenz, Berangere Evrard, Marion Drouin, Emmanuel Merieau, Caroline Mary, Kevin Biteau, Emmanuelle Wilhelm, Cécile Batty, Vanessa Gauttier, Irene Baccelli, Nicolas Poirier, Elise Chiffoleau
The inflammatory response is a key mechanism for the elimination of injurious agents but must be tightly controlled to prevent additional tissue damage and progression to persistent inflammation. C-type lectin receptors expressed mostly by myeloid cells play a crucial role in the regulation of inflammation by recognizing molecular patterns released by injured tissues. We recently showed that the C-type lectin receptor CLEC-1 is able to recognize necrotic cells. However, its role in the acute inflammatory response following tissue damage had not yet been investigated...
February 14, 2024: Journal of Immunology
https://read.qxmd.com/read/38342010/early-life-exposure-to-mycotoxin-zearalenone-exacerbates-aberrant-immune-response-oxidative-stress-and-mortality-of-caenorhabditis-elegans-under-pathogen-bacillus-thuringiensis-infection
#8
JOURNAL ARTICLE
Chun Ming How, Yong-Shan Li, Wei-Yun Huang, Chia-Cheng Wei
Zearalenone (ZEN) is a prevalent mycotoxin that severely impacts human and animal health. However, the possible interactions between ZEN exposure, pathogen infection, immune system, and reactive oxygen species (ROS) were rarely investigated. We studied the effects of early-life ZEN (50 µM) exposure on the immune response of Caenorhabditis elegans against Bacillus thuringiensis infection and the associated mechanisms. The transcriptomic responses of C. elegans after early-life ZEN exposure were investigated using RNA sequencing and followed by verification using quantitative PCR analysis...
March 1, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38277799/evaluation-of-the-combination-of-virtual-simulation-and-in-person-simulation-among-undergraduate-nursing-students-a-mixed-methods-study
#9
JOURNAL ARTICLE
Fengping Han, Sanli Jin
AIM: This study aimed to evaluate the combination of virtual simulation and in-person simulation among undergraduate nursing students. BACKGROUND: At present, in-person simulation is the main form of simulation in China. With the development of computer technology, computer-based virtual simulation is gradually applied in simulation and has shown unique advantages. However, simulation format that combines virtual simulation with in-person simulation is rare in China...
January 20, 2024: Nurse Education in Practice
https://read.qxmd.com/read/38257755/ecohiv-infected-mice-show-no-signs-of-platelet-activation
#10
JOURNAL ARTICLE
Hammodah R Alfar, Dominic Ngima Nthenge-Ngumbau, Kathryn E Saatman, Sidney W Whiteheart
Platelets express several surface receptors that could interact with different viruses. To understand the mechanisms of HIV-1's interaction with platelets, we chose the EcoHIV model. While EcoHIV is an established model for neuroAIDS, its effects on platelets are ill-defined. Our results indicate that EcoHIV behaves differently from HIV-1 and is cleared from circulation after 48 h post-infection. The EcoHIV course of infection resembles an HIV-1 infection under the effects of combined antiretroviral therapy (cART) since infected mice stayed immunocompetent and the virus was readily detected in the spleen...
December 29, 2023: Viruses
https://read.qxmd.com/read/38214399/immune-and-metabolic-perturbations-in-covid-19-associated-pulmonary-mucormycosis-a-transcriptome-analysis-of-innate-immune-cells
#11
JOURNAL ARTICLE
Manpreet Dhaliwal, Valliappan Muthu, Arunima Sharma, Khem Raj, Shivaprakash M Rudramurthy, Ritesh Agarwal, Harsimran Kaur, Amit Rawat, Surjit Singh, Arunaloke Chakrabarti
BACKGROUND AND OBJECTIVES: The mechanisms underlying COVID-19-associated pulmonary mucormycosis (CAPM) remain unclear. We use a transcriptomic analysis of the innate immune cells to investigate the host immune and metabolic response pathways in patients with CAPM. PATIENTS AND METHODS: We enrolled subjects with CAPM (n = 5), pulmonary mucormycosis (PM) without COVID-19 (n = 5), COVID-19 (without mucormycosis, n = 5), healthy controls (n = 5) without comorbid illness and negative for SARS-CoV-2...
January 2024: Mycoses
https://read.qxmd.com/read/38193585/a-change-of-rhodocytin-s-suprastructure-turns-the-agonist-into-an-antagonist-of-tumor-cell-induced-platelet-aggregation
#12
JOURNAL ARTICLE
Wolfgang M J Obermann, Simone König, Mascha K Feickert, Raquel Sanz-Soler, Johannes A Eble
Cancer cells circulating in the blood attach to platelets by direct cell-cell interactions via several receptor-counterreceptor contacts and indirectly by fibrin bridges which connect the two cell types by distinct integrin receptors. In the microenvironment of these tumor cell platelet aggregates (TCPAs), the tumor cells are shielded from the shear stress of the blood flow and from attack by the immune system. This supports hematogenous metastasis and tumor cell induced thrombosis. Platelet activation is triggered by binding of podoplanin on cancer cells to the platelet receptor Clec-2...
January 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38187828/abnormalities-in-c-type-lectin-like-receptor-2-in-a-patient-with-gorham-stout-disease-the-first-case-report
#13
Saori Oishi, Nagaharu Tsukiji, Takahiro Segawa, Katsuhiro Takano, Norio Hasuda, Katsue Suzuki-Inoue
BACKGROUND: Gorham-Stout disease (GSD) is a form of lymphangiomatosis of unknown etiology, characterized by abnormal distribution of lymphatic vessels. Platelets and lymphangiogenesis are closely related via C-type lectin-like receptor 2 (CLEC-2)/podoplanin. KEY CLINICAL QUESTION: Despite similarities between abnormal lymphatic vessels in CLEC-2-deficient mice and patients with GSD, whether CLEC-2 on platelets is involved in GSD pathogenesis is unknown. CLINICAL APPROACH: We examined CLEC-2 expression in platelets of a patient with lethal GSD...
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38154108/the-peptide-acein-promotes-dopamine-secretion-through-clec-126-to-extend-the-lifespan-of-elderly-c-elegans
#14
JOURNAL ARTICLE
Jiaqi Wang, Dong Wang, Sarra Setrerrahmane, Jean Martinez, Han-Mei Xu
Dopamine plays a crucial role in regulating brain activity and movement and modulating human behavior, cognition and mood. Regulating dopamine signaling may improve cognitive abilities and physical functions during aging. Acein, a nonapeptide of sequence H-Pro-Pro-Thr-Thr-Thr-Lys-Phe-Ala-Ala-OH is able to stimulate dopamine secretion in the brain. By using genetic editing and lifespan investigation in C. elegans , we showed that the lack of the C-type lectin domain-containing protein clec-126 significantly suppressed the aging phenotype and prolonged lifespan, while overexpression of clec-126 promoted aging-related phenotypes and accelerated the aging process...
December 27, 2023: Aging
https://read.qxmd.com/read/38112828/growing-season-carbon-budget-of-alpine-meadow-ecosystem-in-the-qinghai-lake-basin-a-continued-carbon-sink-through-this-century-according-to-the-biome-bgc-model
#15
JOURNAL ARTICLE
Meng-Ya Zhang, Yu-Jun Ma, Peng Chen, Fang-Zhong Shi, Jun-Qi Wei
BACKGROUND: The alpine meadow is one of the most important ecosystems in the Qinghai-Tibet Plateau (QTP), and critically sensitive to climate change and human activities. Thus, it is crucial to precisely reveal the current state and predict future trends in the carbon budget of the alpine meadow ecosystem. The objective of this study was to explore the applicability of the Biome-BGC model (BBGC) in the Qinghai Lake Basin (QLB), identify the key parameters affecting the variation of net ecosystem exchange (NEE), and further predict the future trends in carbon budget in the QLB...
December 19, 2023: Carbon Balance and Management
https://read.qxmd.com/read/38077334/role-of-the-co-stimulatory-molecule-inducible-t-cell-co-stimulator-ligand-icosl-in-the-progression-of-experimental-metabolic-dysfunction-associated-steatohepatitis
#16
JOURNAL ARTICLE
Alessia Provera, Naresh Naik Ramavath, Laila Lavanya Gadipudi, Casimiro Luca Gigliotti, Elena Boggio, Cristina Vecchio, Ian Stoppa, Roberta Rolla, Renzo Boldorini, Mario Pirisi, Carlo Smirne, Emanuele Albano, Umberto Dianzani, Salvatore Sutti
BACKGROUND AND AIMS: Inducible T-cell Co-Stimulator (ICOS) present on T-lymphocytes and its ligand ICOSL expressed by myeloid cells play multiple roles in regulating T-cell functions. However, recent evidence indicates that reverse signalling involving ICOSL is also important in directing the differentiation of monocyte-derived cells. In this study, we investigated the involvement of ICOS/ICOSL dyad in modulating macrophage functions during the evolution of metabolic dysfunction-associated steatohepatitis (MASH)...
2023: Frontiers in Immunology
https://read.qxmd.com/read/38067218/c-type-lectin-like-receptor-2-expression-is-decreased-upon-platelet-activation-and-is-lower-in-most-tumor-entities-compared-to-healthy-controls
#17
JOURNAL ARTICLE
Mani Etemad, Foteini Christodoulou, Stefanie Uhlig, Jessica C Hassel, Petra Schrotz-King, Hermann Brenner, Cornelia M Ulrich, Karen Bieback, Harald Klüter, Peter Bugert
The C-type lectin-like receptor 2 (CLEC-2) is expressed on platelets and mediates binding to podoplanin (PDPN) on various cell types. The binding to circulating tumor cells (CTCs) leads to platelet activation and promotes metastatic spread. An increased level of soluble CLEC-2 (sCLEC-2), presumably released from activated platelets, was shown in patients with thromboinflammatory and malignant disease. However, the functional role of sCLEC-2 and the mechanism of sCLEC-2 release are not known. In this study, we focused on the effect of platelet activation on CLEC-2 expression and the sCLEC-2 plasma level in patients with cancer...
November 22, 2023: Cancers
https://read.qxmd.com/read/38020309/inhibition-of-cancer-cell%C3%A2-platelet-adhesion-as-a-promising-therapeutic-target-for-preventing-peritoneal-dissemination-of-gastric-cancer
#18
JOURNAL ARTICLE
Takashi Nakayama, Ryo Saito, Shinji Furuya, Katsutoshi Shoda, Suguru Maruyma, Koichi Takiguchi, Kensuke Shiraishi, Hidenori Akaike, Yoshihiko Kawaguchi, Hidetake Amemiya, Hiromichi Kawaida, Nagaharu Tsukiji, Toshiaki Shirai, Hideyuki Shinmori, Masami Yamamoto, Sachiyo Nomura, Tetsuya Tsukamoto, Katsue Suzuki-Inoue, Daisuke Ichikawa
Platelets form complexes with gastric cancer (GC) cells via direct contact, enhancing their malignant behavior. In the present study, the molecules responsible for GC cell-platelet interactions were examined and their therapeutic application in inhibiting the peritoneal dissemination of GC was investigated. First, the inhibitory effects of various candidate surface molecules were investigated on platelets and GC cells, such as C-type lectin-like receptor 2 (CLEC-2), glycoprotein VI (GPVI) and integrin αIIbβ3, in the platelet-induced enhancement of GC cell malignant potential...
December 2023: Oncology Letters
https://read.qxmd.com/read/38010137/c-type-lectin-like-receptor-2-clec-2-is-a-key-regulator-of-kappa-carrageenan-induced-tail-thrombosis-model-in-mice
#19
JOURNAL ARTICLE
Ryohei Yokomori, Toshiaki Shirai, Nagaharu Tsukiji, Saori Oishi, Tomoyuki Sasaki, Katsuhiro Takano, Katsue Suzuki-Inoue
Kappa-carrageenan (KCG), which is used to induce thrombosis in laboratory animals for antithrombotic drug screening, can trigger platelet aggregation. However, the cell-surface receptor and related signaling pathways remain unclear. In this study, we investigated the molecular basis of KCG-induced platelet activation using light-transmittance aggregometry, flow cytometry, western blotting, and surface plasmon resonance assays using platelets from platelet receptor-deficient mice and recombinant proteins. KCG-induced tail thrombosis was also evaluated in mice lacking the platelet receptor...
December 2023: Platelets
https://read.qxmd.com/read/37967855/diphenyl-tetrazol-propanamide-derivatives-act-as-dual-specific-antagonists-of-platelet-clec-2-and-gpvi
#20
JOURNAL ARTICLE
Nobuo Watanabe, Yoshiko Shinozaki, Sanae Ogiwara, Riko Miyagasako, Ayumi Sasaki, Yusuke Suzuki, Junko Kato, Natsuko Fukunishi, Yoshinori Okada, Takeshi Saito, Yumi Iida, Misaki Higashiseto, Haruchika Masuda, Kazuhito Goto, Mari Amino, Tomoatsu Tsuji, Seiji Morita, Eiichiro Nagata, Yoshihide Nakagawa, Noriaki Hirayama, Sadaki Inokuchi
Platelet C-type lectin-like receptor 2 (CLEC-2) induces platelet activation and aggregation after clustering by its ligand podoplanin (PDPN). PDPN, which is not normally expressed in cells in contact with blood flow, is induced in inflammatory immune cells and some malignant tumor cells, thereby increasing the risk of venous thromboembolism (VTE) and tumor metastasis. Therefore, small-molecule compounds that can interfere with the PDPN-CLEC-2 axis have the potential to become selective antiplatelet agents. Using molecular docking analysis of CLEC-2 and a PDPN-CLEC-2 binding-inhibition assay, we identified a group of diphenyl-tetrazol-propanamide derivatives as novel CLEC-2 inhibitors...
November 15, 2023: Thrombosis and Haemostasis
keyword
keyword
78865
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.