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Structural heart inter

G Valenza, A Romigi, L Citi, F Placidi, F Izzi, M Albanese, E P Scilingo, M G Marciani, A Duggento, M Guerrisi, N Toschi, R Barbieri, G Valenza, A Romigi, L Citi, F Placidi, F Izzi, M Albanese, E P Scilingo, M G Marciani, A Duggento, M Guerrisi, N Toschi, R Barbieri, M Guerrisi, F Izzi, F Placidi, A Romigi, E P Scilingo, A Duggento, M Albanese, N Toschi, M G Marciani, R Barbieri, G Valenza, L Citi
Symptoms of temporal lobe epilepsy (TLE) are frequently associated with autonomic dysregulation, whose underlying biological processes are thought to strongly contribute to sudden unexpected death in epilepsy (SUDEP). While abnormal cardiovascular patterns commonly occur during ictal events, putative patterns of autonomic cardiac effects during pre-ictal (PRE) periods (i.e. periods preceding seizures) are still unknown. In this study, we investigated TLE-related heart rate variability (HRV) through instantaneous, nonlinear estimates of cardiovascular oscillations during inter-ictal (INT) and PRE periods...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Julia Schipke, Christina Brandenberger, Alexandra Rajces, Martin Manninger, Alessio Alogna, Heiner Post, Christian Mühlfeld
Fibrotic remodeling of the heart is a frequent condition linked to various diseases and cardiac dysfunction. Collagen quantification is an important objective in cardiac fibrosis research; however, a variety of different histological methods are currently used that may differ in accuracy. Here, frequently applied collagen quantification techniques were compared. A porcine model of early-stage heart failure with preserved ejection fraction was used as example. Semi-automated threshold analyses were imprecise, mainly due to inclusion of non-collagen structures or failure to detect certain collagen deposits...
January 26, 2017: Journal of Applied Physiology
H Liu, P Dong, L Xing
PURPOSE: Traditional radiotherapy inverse planning relies on the weighting factors to phenomenologically balance the conflicting criteria for different structures. The resulting manual trial-and-error determination of the weights has long been recognized as the most time-consuming part of treatment planning. The purpose of this work is to develop an inverse planning framework that parameterizes the inter-structural dosimetric tradeoff among with physically more meaningful quantities to simplify the search for a clinically sensible plan...
June 2016: Medical Physics
J Hammers, J Matney, O Kaidar-Person, T Zagar, L Marks, S Das, P Mavroidis
PURPOSE: To quantitatively assess the effects of inter-fraction changes in organ shape and location on the delivered dose distribution to the organs at risk (OAR) in lung cancer patients. METHODS: This study analyzes treatment data of 10 patients, who were treated to 60Gy in 30 fractions. In each fraction a cone beam CT (CBCT) was acquired. Each CBCT was registered with the planning CT using deformable registration tools within MIM Software. The daily setup shifts were used to translate the planned dose distribution on the deformed planning CT...
June 2016: Medical Physics
José David Arroja, Haran Burri, Chan Il Park, Philippe Giraudet, Marc Zimmermann
PURPOSE: The aim of the present study was to define the atrial electrical substrate in patients with paroxysmal atrial fibrillation (AF) occurring in the absence of overt structural heart disease and to assess if electrophysiological parameters could predict AF recurrence after radiofrequency ablation in this population. METHODS AND RESULTS: 45 consecutive patients (39 male, age 59 ± 10 years) with paroxysmal AF and without overt structural heart disease, referred for radiofrequency catheter ablation, were prospectively enrolled...
September 2016: Indian Pacing and Electrophysiology Journal
Rongrong Zhou, Zhongxing Liao, Tinsu Pan, Sarah A Milgrom, Chelsea C Pinnix, Anhui Shi, Linglong Tang, Ju Yang, Ying Liu, Daniel Gomez, Quynh-Nhu Nguyen, Bouthaina S Dabaja, Laurence Court, Jinzhong Yang
PURPOSE: To develop and validate a set of atlases for auto-contouring cardiac substructures. METHODS: Eight radiation oncologists manually and independently delineated 15 cardiac substructures from noncontrast CT images of 6 patients by referring to their respective fused contrast CT images. Individual contours were fused together for each structure, edited by 2 physicians, and became atlases to delineate other 6 patients. The auto-delineated contours of the 6 additional patients became templates for manual contouring...
January 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Christopher P Bridge, Christos Ioannou, J Alison Noble
Interpretation of ultrasound videos of the fetal heart is crucial for the antenatal diagnosis of congenital heart disease (CHD). We believe that automated image analysis techniques could make an important contribution towards improving CHD detection rates. However, to our knowledge, no previous work has been done in this area. With this goal in mind, this paper presents a framework for tracking the key variables that describe the content of each frame of freehand 2D ultrasound scanning videos of the healthy fetal heart...
November 19, 2016: Medical Image Analysis
Giselle Darahem Tedesco, Marilim de Souza Bezerra, Fernanda Silveira Bello Barros, Wellington P Martins, Luciano Marcondes Machado Nardozza, Milene Carvalho Carrilho, Antonio Fernandes Moron, Francisco Herlânio Costa Carvalho, Liliam Cristine Rolo, Edward Araujo Júnior
To determine reference values for fetal heart biometric parameters using the spatiotemporal image correlation (STIC) M mode and their applicability in congenital heart diseases (CHDs). A cross-sectional prospective study was conducted with 300 singleton pregnancies between 20 and 33 + 6 weeks of gestation. Right ventricular wall thickness (RVWT), interventricular septum thickness (IVST), and left ventricular wall thickness (LVWT) were measured off-line using the STIC-M mode with the cursor perpendicular to the interventricular septum...
November 23, 2016: Pediatric Cardiology
Ziwu Zhou, Fei Han, Stanislas Rapacchi, Kim-Lien Nguyen, Daniel Z Brunengraber, Grace-Hyun J Kim, J Paul Finn, Peng Hu
The purpose of this work was to validate a parallel imaging (PI) and compressed sensing (CS) combined reconstruction method for a recently proposed 4D non-breath-held, multiphase, steady-state imaging technique (MUSIC) cardiovascular MRI in a cohort of pediatric congenital heart disease patients. We implemented a graphics processing unit accelerated CS-PI combined reconstruction method and applied it in 13 pediatric patients who underwent cardiovascular MRI after ferumoxytol administration. Conventional breath-held contrast-enhanced magnetic resonance angiography (CE-MRA) was first performed during the first pass of ferumoxytol injection, followed by the original MUSIC and the proposed CS-PI MUSIC during the steady-state distribution phase of ferumoxytol...
January 2017: NMR in Biomedicine
Jamilah Abdur-Rahim, Yoichi Morales, Pankaj Gupta, Ichiro Umata, Atsushi Watanabe, Jani Even, Takayuki Suyama, Shin Ishii
This paper presents a study on multi-modal human emotional state detection while riding a powered wheelchair (PMV; Personal Mobility Vehicle) in an indoor labyrinth-like environment. The study reports findings on the habituation of human stress response during self-driving. In addition, the effects of "loss of controllability", change in the role of the driver to a passenger, are investigated via an autonomous driving modality. The multi-modal emotional state detector sensing framework consists of four sensing devices: electroencephalograph (EEG), heart inter-beat interval (IBI), galvanic skin response (GSR) and stressor level lever (in the case of autonomous riding)...
2016: PloS One
James A Letts, Gianluca Degliesposti, Karol Fiedorczuk, Mark Skehel, Leonid A Sazanov
NADH-ubiquinone oxidoreductase (complex I) is the largest (∼1 MDa) and the least characterized complex of the mitochondrial electron transport chain. Because of the ease of sample availability, previous work has focused almost exclusively on bovine complex I. However, only medium resolution structural analyses of this complex have been reported. Working with other mammalian complex I homologues is a potential approach for overcoming these limitations. Due to the inherent difficulty of expressing large membrane protein complexes, screening of complex I homologues is limited to large mammals reared for human consumption...
November 18, 2016: Journal of Biological Chemistry
Bi Xia Ngooi, Tanya L Packer, George Kephart, Grace Warner, Karen Wei Ling Koh, Raymond Ching Chiew Wong, Serene Peiying Lim
PURPOSE: The Patient Activation Measure (PAM-13) measures patients' knowledge, skill, and confidence in chronic condition self-management. The purpose of this study was to assess the validity of PAM-13 (English version) among English-speaking adults with cardiac conditions in Singapore. METHODS: A cross-sectional study was conducted in a convenient sample of 270 heart clinic patients. Using the unitary concept of validity, evidence of (1) internal structure via data quality, unidimensionality, differential item functioning, and internal consistency, (2) response process through item difficulty and item fit using Rasch modeling, and (3) relationship to other variables via correlations with depression and self-efficacy were examined...
September 19, 2016: Quality of Life Research
Sylvère Störmann, Melanie Stankiewicz, Patricia Raes, Christina Berchtold, Yvonne Kosanke, Gabrielle Illes, Peter Loose, Matthias W Angstwurm
INTRODUCTION: The clinical examination and other practical clinical skills are fundamental to guide diagnosis and therapy. The teaching of such practical skills has gained significance through legislative changes and adjustments of the curricula of medical schools in Germany. We sought to find out how well final year undergraduate medical students master practical clinical skills. METHODS: We conducted a formative 4-station objective structured clinical examination (OSCE) focused on practical clinical skills during the final year of undergraduate medical education...
2016: GMS Journal for Medical Education
Rinat Gabbay-Benziv, E Albert Reece, Fang Wang, Amnon Bar-Shir, Chris Harman, Ozhan M Turan, Peixin Yang, Sifa Turan
BACKGROUND: The mouse embryo is ideal for studying human cardiac development. However, laboratory discoveries do not easily translate into clinical findings partially because of histological diagnostic techniques that induce artifacts and lack standardization. AIM: To present a step-wise approach using 17.6T MRI, for evaluation of mice embryonic heart and accurate identification of congenital heart defects. SUBJECTS: 17.5-embryonic days embryos from low-risk (non-diabetic) and high-risk (diabetic) model dams...
August 26, 2016: Magnetic Resonance Imaging
D Lambert, P-Y Marie, P Lacolley, A Benetos, L Joly
OBJECTIVE: Aging led to the development of a proinflammatory phenotype and organ dysfunction. In situations of metabolic syndrome, it is associated with an increase in arterial stiffness and blood pressure.The main objective of this project is to establish a link between inflammation and arterial aging in a situation of metabolic syndrome in arterial and heart levels. DESIGN AND METHOD: The animal model chosen was a murine model developing metabolic syndrome. Mice received during a year, a high fat diet or a control diet...
September 2016: Journal of Hypertension
Márta Sárközy, Gergő Szűcs, Veronika Fekete, Márton Pipicz, Katalin Éder, Renáta Gáspár, Andrea Sója, Judit Pipis, Péter Ferdinandy, Csaba Csonka, Tamás Csont
BACKGROUND: There is a spectacular rise in the global prevalence of type 2 diabetes mellitus (T2DM) due to the worldwide obesity epidemic. However, a significant proportion of T2DM patients are non-obese and they also have an increased risk of cardiovascular diseases. As the Goto-Kakizaki (GK) rat is a well-known model of non-obese T2DM, the goal of this study was to investigate the effect of non-obese T2DM on cardiac alterations of the transcriptome in GK rats. METHODS: Fasting blood glucose, serum insulin and cholesterol levels were measured at 7, 11, and 15 weeks of age in male GK and control rats...
5, 2016: Cardiovascular Diabetology
R Akhtar, H K Graham, B Derby, M J Sherratt, A W Trafford, R S Chadwick, N Gavara
Age-related aortic stiffening is associated with cardiovascular diseases such as heart failure. The mechanical functions of the main structural components of the aorta, such as collagen and elastin, are determined in part by their organisation at the micrometer length scale. With age and disease both components undergo aberrant remodelling, hence, there is a need for accurate characterisation of the biomechanical properties at this length scale. In this study we used a frequency-modulated atomic force microscopy (FM-AFM) technique on a model of ageing in female sheep aorta (young: ~18 months, old: >8 years) to measure the micromechanical properties of the medial layer of the ascending aorta...
December 2016: Journal of the Mechanical Behavior of Biomedical Materials
Vanessa Cabra, Takashi Murayama, Montserrat Samsó
In heart, type-2 ryanodine receptor (RyR2) forms discrete supramolecular clusters in the sarcoplasmic reticulum known as calcium release units (CRUs), which are responsible for most of the Ca(2+) released for muscle contraction. To learn about the substructure of the CRU, we sought to determine whether RyR2s have the ability to self-associate in the absence of other factors and if so, whether they do it in a specific manner. Purified RyR2 was negatively stained and imaged on the transmission electron microscope, and RyR2 particles closely associated were further analyzed using bias-free multivariate statistical analysis and classification...
June 21, 2016: Biophysical Journal
T Kairn, S B Crowe, C M Langton, J V Trapp
This study provides a bulk, retrospective analysis of 151 breast and chest wall radiotherapy treatment plans, as a small-scale demonstration of the potential breadth and value of the information that may be obtained from clinical data mining. The treatments were planned at three centres belonging to one organisation over a period of 3 months. All 151 plans were used to evaluate inter-centre consistency and compliance with a local planning protocol. A subset of 79 plans, from one centre, were used in a more detailed evaluation of the effects of anatomical asymmetry on heart and lung dose, the effects of a metallic temporary tissue expander port on dose homogeneity and the overall conformity and homogeneity achieved in routine breast treatment planning...
September 2016: Australasian Physical & Engineering Sciences in Medicine
Vicky Wang, Christopher Casta, Yue-Min Zhu, Brett Cowan, Pierre Croisille, Alistair Young, Patrick Clarysse, Martyn Nash
Cardiac myofibre deformation is an important determinant of the mechanical function of the heart. Quantification of myofibre strain relies on 3D measurements of ventricular wall motion interpreted with respect to the tissue microstructure. In this study, we estimated in vivo myofibre strain using 3D structural and functional atlases of the human heart. A finite element modelling framework was developed to incorporate myofibre orientations of the left ventricle (LV) extracted from 7 explanted normal human hearts imaged ex-vivo with diffusion tensor magnetic resonance imaging (DTMRI) and kinematic measurements from 7 normal volunteers imaged in vivo with tagged MRI...
June 14, 2016: IEEE Transactions on Medical Imaging
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