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https://www.readbyqxmd.com/read/29141361/-effect-of-probucol-on-preventing-contrast-induced-nephropathy-in-patients-undergoing-percutaneous-coronary-intervention
#1
X Q Suo, S C Yang, Z H Ma, T T Sun, W Y Zhang, H L Cong, W H Lin, C Z Lu, F S Tian, N K Fu
Objective: To investigate the preventive effect, possible mechanism and safety of probucol on contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD). Methods: A total of 641 patients with coronary heart disease were consecutively enrolled from Department of Cardiology, in Tianjin Chest Hospital, Tianjin TEDA International Cardiovascular Hospital, Tianjin First Central Hospital, Tianjin Fourth Central Hospital. They were randomly divided into probucol group (n=321) and control group (n=320)...
November 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29131062/cardio-renal-determinants-of-erectile-dysfunction-in-primary-prevention-a-cross-sectional-study
#2
Vilma Dzenkeviciute, Zaneta Petrulioniene, Egidija Rinkuniene, Virginijus Sapoka, Marija Petrylaite, Jolita Badariene
OBJECTIVE: To investigate the association between severity of erectile dysfunction, cardiovascular risk and target organ (heart, renal, vascular) damage in men free of cardiovascular diseases (CV). SUBJECTS AND METHODS: This study included 182 men: 100 with erectile dysfunction (ED) (IIEF mean score ≤ 21) and 82 without ED (IIEF mean score > 21). The ED was assessed using the International Index of Erectile Function (IIEF-5). Ultrasound was used to evaluate carotid plaques and left ventricular mass, geometry and diastolic function...
November 5, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29114384/treatment-with-insulin-analogs-and-prevalence-of-cardiovascular-complications-in-patients-with-type-1-diabetes
#3
Christoph Hasslacher, Justo Lorenzo Bermejo
Background: A lower incidence of cardiovascular events has been reported in type 2 diabetes patients treated with insulin analogs (IAs). Corresponding data on people affected by type 1 diabetes are not available yet. Methodology: We investigated demographic and clinical data from 509 type 1 diabetics, who were treated in an outpatient clinic from 2006 to 2012. Multiple logistic regression was used to investigate the relationship between the type of insulin treatment and the prevalence of cardiovascular (CV) complications, that is, presence of coronary heart, cerebrovascular and peripheral arterial diseases, adjusting for potential confounders...
November 2017: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29113983/fgf23-concentration-and-apol1-genotype-are-novel-predictors-of-mortality-in-african-americans-with-type-2-diabetes
#4
Gary C Chan, Jasmin Divers, Gregory B Russell, Carl D Langefeld, Lynne E Wagenknecht, Fang-Chi Hsu, Jianzhao Xu, S Carrie Smith, Nicholette D Palmer, Pamela J Hicks, Donald W Bowden, Thomas C Register, Lijun Ma, J Jeffrey Carr, Barry I Freedman
OBJECTIVE: Cardiovascular and renal complications contribute to higher mortality in patients with diabetes. We assessed novel and conventional predictors of mortality in African American-Diabetes Heart Study participants. RESEARCH DESIGN AND METHODS: Associations between mortality and subclinical atherosclerosis, urine albumin-to-creatinine ratio (UACR), estimated glomerular filtration rate (eGFR), plasma fibroblast growth factor 23 (FGF23) concentration, African ancestry proportion, and apolipoprotein L1 genotypes (APOL1) were assessed in 513 African Americans with type 2 diabetes; analyses were performed using Cox proportional hazards models...
November 7, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29106471/kidney-function-modifies-the-selection-of-treatment-strategies-and-long-term-survival-in-stable-ischemic-heart-disease-insights-from-the-alberta-provincial-project-for-outcomes-assessment-in-coronary-heart-disease-approach-registry
#5
Jay S Shavadia, Danielle A Southern, Matthew T James, Robert C Welsh, Kevin R Bainey
Aims: Patients with chronic kidney disease (CKD) have been under-represented in stable ischemic heart disease (SIHD) trials despite their heightened risk of cardiovascular mortality. We examine associations between kidney disease, treatment selection, and long-term survival in patients with SIHD. Methods and Results: SIHD patients with angiographically significant stenosis (≥70%) were categorized by renal function (dialysis-dependent, severe CKD [eGFR<30], mild-moderate CKD [eGFR30-59] and no CKD [eGFR≥60]), and by treatment groups (revascularization ≤ 3 months of angiogram [CABG or PCI] versus medical therapy)...
November 2, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29102959/randomized-controlled-trial-of-trc101-to-increase-serum-bicarbonate-in-patients-with-ckd
#6
David A Bushinsky, Thomas Hostetter, Gerrit Klaerner, Yuri Stasiv, Claire Lockey, Sarah McNulty, Angela Lee, Dawn Parsell, Vandana Mathur, Elizabeth Li, Jerry Buysse, Robert Alpern
BACKGROUND AND OBJECTIVES: Metabolic acidosis is common in patients with CKD and has significant adverse effects on kidney, muscle, and bone. We tested the efficacy and safety of TRC101, a novel, sodium-free, nonabsorbed hydrochloric acid binder, to increase serum bicarbonate in patients with CKD and metabolic acidosis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: One hundred thirty-five patients were enrolled in this randomized, double-blind, placebo-controlled, multicenter, in-unit study (designated the TRCA-101 Study)...
November 4, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29098408/increased-serum-wisteria-floribunda-agglutinin-positive-mac-2-binding-protein-mac-2-binding-protein-glycosylation-isomer-in-chronic-heart-failure-a-pilot-study
#7
Atsushi Okada, Hideaki Kanzaki, Yasuhiro Hamatani, Seiji Takashio, Hiroyuki Takahama, Makoto Amaki, Takuya Hasegawa, Yasuo Sugano, Satoshi Yasuda, Toshihisa Anzai
BACKGROUND: Serum Wisteria floribunda agglutinin positive Mac-2 binding protein (WFA(+)-M2BP) or Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) is a novel biomarker currently applied for evaluating hepatic fibrosis. The aim of this study was to evaluate the utility of serum WFA(+)-M2BP level as a biomarker in chronic heart failure (HF) patients with abnormal liver function. METHODS AND RESULTS: Fifty chronic HF patients who underwent measurement of serum WFA(+)-M2BP were evaluated...
November 2, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29097680/epigenome-wide-association-studies-identify-dna-methylation-associated-with-kidney-function
#8
Audrey Y Chu, Adrienne Tin, Pascal Schlosser, Yi-An Ko, Chengxiang Qiu, Chen Yao, Roby Joehanes, Morgan E Grams, Liming Liang, Caroline A Gluck, Chunyu Liu, Josef Coresh, Shih-Jen Hwang, Daniel Levy, Eric Boerwinkle, James S Pankow, Qiong Yang, Myriam Fornage, Caroline S Fox, Katalin Susztak, Anna Köttgen
Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate (eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to CKD. Here we present epigenome-wide association studies of eGFR and CKD using whole-blood DNA methylation of 2264 ARIC Study and 2595 Framingham Heart Study participants to identify epigenetic signatures of kidney function. Of 19 CpG sites significantly associated (P < 1e-07) with eGFR/CKD and replicated, five also associate with renal fibrosis in biopsies from CKD patients and show concordant DNA methylation changes in kidney cortex...
November 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/29082834/kidney-function-is-associated-with-short-term-mid-term-and-long-term-clinical-outcome-after-coronary-angiography-and-intervention
#9
Andrie G Panayiotou, Jonas Spaak, Majid Kalani
BACKGROUND: Patients with kidney dysfunction are at risk of developing ischaemic heart disease. We investigated the association between eGFR and early-, mid- and long-term clinical outcome in patients undergoing coronary angiography and intervention. METHODS: Retrospective study on 4968 patients with complete data on eGFR, 65% male and aged 32-80 years, admitted to Danderyd University Hospital, Stockholm, Sweden for coronary angiography and intervention from 2006 to 2008...
October 30, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/29064262/prognostic-comparison-between-creatinine-based-glomerular-filtration-rate-formulas-for-the-prediction-of-10-year-outcome-in-patients-with-non-st-elevation-acute-coronary-syndrome-treated-by-percutaneous-coronary-intervention
#10
Piercarlo Ballo, Tania Chechi, Gaia Spaziani, Veronica Fibbi, Duccio Conti, Giuseppe Ferro, Santi Nigrelli, Pietro Dattolo, Antonio Fazi, Giovanni Maria Santoro, Alfredo Zuppiroli, Francesco Pizzarelli
BACKGROUND: Estimated glomerular filtration rate (eGFR) is a predictor of outcome among patients with non-ST-elevation acute coronary syndrome (NSTE-ACS), but which estimation formula provides the best long-term risk stratification in this setting is still unclear. We compared the prognostic performance of four creatinine-based formulas for the prediction of 10-year outcome in a NSTE-ACS population treated by percutaneous coronary intervention. METHODS: In 222 NSTE-ACS patients submitted to percutaneous coronary intervention, eGFR was calculated using four formulas: Cockcroft-Gault, re-expressed modification of diet in renal disease (MDRD), chronic kidney disease epidemiology collaboration (CKD-Epi), and Mayo-quadratic...
March 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29035939/predictors-for-the-development-of-microalbuminuria-and-interaction-with-renal-function
#11
Christos Chatzikyrkou, Jan Menne, Joseph Izzo, Giancarlo Viberti, Ton Rabelink, Luis M Ruilope, Christian Rump, Peter R Mertens, Hermann Haller
AIM: It is important to know which factors predict the development of microalbuminuria in patients with diabetes mellitus type II. MATERIAL: Data from the Randomized Olmesartan and Diabetes Microalbuminuria Prevention Study were used to identify predictors for the new onset of microalbuminuria. Furthermore, the interaction of baseline albuminuria and baseline estimated glomerular filtration rate (eGFR) and the effects of treatment with olmesartan were investigated...
October 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29025406/impact-of-empagliflozin-on-subclinical-left-ventricular-dysfunctions-and-on-the-mechanisms-involved-in-myocardial-disease-progression-in-type-2-diabetes-rationale-and-design-of-the-empa-heart-trial
#12
Andrea Natali, Lorenzo Nesti, Iacopo Fabiani, Enrico Calogero, Vitantonio Di Bello
BACKGROUND: Asymptomatic left ventricular (LV) dysfunction is highly prevalent in type 2 diabetes patients. Unlike the other hypoglycemic drugs, SGLT2 inhibitors have shown potential benefits for reducing cardiovascular death and risk factors, aside from lowering plasma glucose levels. With this study we aim at determining whether the treatment with empagliflozin is associated with an improvement in LV functions in diabetic patients with asymptomatic LV dysfunction against Sitagliptin, which is presumably neutral on myocardial function...
October 12, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29021843/impact-of-baseline-renal-function-on-all-cause-mortality-in-patients-who-underwent-cardiac-resynchronization-therapy-a-systematic-review-and-meta-analysis
#13
REVIEW
G Bazoukis, K P Letsas, P Korantzopoulos, C Thomopoulos, K Vlachos, S Georgopoulos, N Karamichalakis, A Saplaouras, M Efremidis, A Sideris
BACKGROUND: Cardiac resynchronization therapy (CRT) improves both morbidity and mortality in selected patients with heart failure and increased QRS duration. However, chronic kidney disease (CKD) may have an adverse effect on patient outcome. The aim of this systematic review was to analyze the existing data regarding the impact of baseline renal function on all-cause mortality in patients who underwent CRT. METHODS: Medline database was searched systematically, and studies evaluating the effect of baseline renal function on all-cause mortality in patients who underwent CRT were retrieved...
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29020355/effects-of-empagliflozin-on-risk-for-cardiovascular-death-and-heart-failure-hospitalization-across-the-spectrum-of-heart-failure-risk-in-the-empa-reg-outcome%C3%A2-trial
#14
David Fitchett, Javed Butler, Philippe van de Borne, Bernard Zinman, John M Lachin, Christoph Wanner, Hans J Woerle, Stefan Hantel, Jyothis T George, Odd Erik Johansen, Silvio E Inzucchi
Aims: Empagliflozin reduced the risk of cardiovascular (CV) death and heart failure (HF) hospitalizations in patients with type 2 diabetes (T2D) and established CV disease (CVD) in the EMPA-REG OUTCOME® trial. We investigated whether the benefit of empagliflozin was observed across the spectrum of HF risk. Methods and results: Seven thousand and twenty patients with T2D (HbA1c 7-10% and eGFR > 30 mL/min/1.73 m2) were treated with empagliflozin 10 or 25 mg, or placebo once daily and followed for median 3...
August 28, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28976899/community-noise-exposure-and-its-effect-on-blood-pressure-and-renal-function-in-patients-with-hypertension-and-cardiovascular-disease
#15
Angel M Dzhambov, Mariya P Tokmakova, Penka D Gatseva, Nikolai G Zdravkov, Dolina G Gencheva, Nevena G Ivanova, Krasimir I Karastanev, Stefka V Vladeva, Aleksandar T Donchev, Svetlan M Dermendzhiev
BACKGROUND: Road traffic noise (RTN) is a risk factor for cardiovascular disease (CVD) and hypertension; however, few studies have looked into its association with blood pressure (BP) and renal function in patients with prior CVD. AIM: This study aimed to explore the effect of residential RTN exposure on BP and renal function in patients with CVD from Plovdiv Province. MATERIALS AND METHODS: We included 217 patients with ischemic heart disease and/or hypertension from three tertiary hospitals in the city of Plovdiv (March - May 2016)...
September 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28964554/impact-of-cardio-renal-syndrome-on-adverse-outcomes-in-patients-with-fabry-disease-in-a-long-term-follow-up
#16
M Siegenthaler, U Huynh-Do, P Krayenbuehl, E Pollock, U Widmer, H Debaix, E Olinger, M Frank, M Namdar, F Ruschitzka, A Nowak
AIMS: Fabry disease (FD) is a rare X-linked lysosomal storage disease with a deficiency of α-galactosidase A leading to progressive sphingolipid accumulation in different organs, among them heart and kidney. We evaluated the impact of cardio-renal syndrome (CRS) on the incidence of major cardiovascular complications and death in a prospective FD cohort. METHODS AND RESULTS: A total of 104 genetically proven FD patients were annually followed at the University Hospitals Zurich and Bern...
December 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28959123/ultrasound-assessment-of-kidney-volume-in-patients-with-acute-decompensated-heart-failure-a-predictor-of-diuretic-resistance
#17
Shinobu Sugihara, Yoshiharu Kinugasa, Tomoaki Takata, Takaaki Sugihara, Keiko Hosho, Chitose Imai, Hiromi Ito, Kensaku Yamada, Masahiko Kato, Kazuhiro Yamamoto
BACKGROUND: Diuretics are essential for treating acute decompensated heart failure (ADHF), but the response is inconsistent. This study aimed to clarify whether kidney volume as assessed by ultrasound (US) predicts diuretic resistance in patients with ADHF. METHODS: We enrolled 29 patients with ADHF and 32 controls. Height-adjusted kidney volume was assessed by US. We divided patients into two groups based on the median value of total daily use of furosemide (intravenous dose plus 0...
September 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/28939714/kidney-disease-measures-and-left-ventricular-structure-and-function-the-atherosclerosis-risk-in-communities-study
#18
Kunihiro Matsushita, Lucia Kwak, Yingying Sang, Shoshana H Ballew, Hicham Skali, Amil M Shah, Josef Coresh, Scott Solomon
BACKGROUND: Heart failure is one of the most important complications of chronic kidney disease (CKD). However, few studies comprehensively investigated left ventricular (LV) structure and function in relation to 2 key CKD measures, estimated glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (ACR). METHODS AND RESULTS: Among 4175 ARIC (Atherosclerosis Risk in Communities) participants (aged 66-90 years during 2011-2013), we quantified the association of eGFR and ACR with echocardiogram parameters of LV mass, size, systolic function, and diastolic function...
September 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28934189/cystatin-c-as-a-predictor-of-cardiovascular-outcomes-in-a-hypertensive-population
#19
R Garcia-Carretero, L Vigil-Medina, O Barquero-Perez, R Goya-Esteban, I Mora-Jimenez, C Soguero-Ruiz, J Ramos-Lopez
Calculating the estimated glomerular filtration rate (eGFR) using creatinine-based equations may underestimate cardiovascular risk. Cystatin C-based eGFR may be a stronger prognostic biomarker than creatinine-based eGFR when assessing cardiovascular outcomes and mortality. Our aim was to determine whether levels of serum cystatin C, as an estimator of GFR, had a higher predictive value than creatinine-based eGFR for incident cardiovascular disease among hypertensive patients. We retrospectively analyzed the records of 2016 hypertensive patients from the Hypertension Unit at Mostoles University Hospital between 2006 and 2016...
December 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28930797/optimizing-the-safety-profile-of-everolimus-by-delayed-initiation-in-de-novo-heart-transplant-recipients-results-of-the-prospective-randomized-study-everheart
#20
Luciano Potena, Carlo Pellegrini, Francesco Grigioni, Cristiano Amarelli, Ugolino Livi, Massimo Maccherini, Gabriella Masciocco, Giuseppe Faggian, Paola Lilla Della Monica, Gino Gerosa, Nicola Marraudino, Marco Corda, Massimo Boffini
BACKGROUND: Although everolimus potentially improves long-term heart transplantation (HTx) outcomes, its early postoperative safety profile had raised concerns and needs optimization. METHODS: This 6-month, open-label, multicenter randomized trial was designed to compare the cumulative incidence of a primary composite safety endpoint comprising wound healing delays, pericardial effusion (PCEs), pleural effusion (PLEs) needing drainage, and renal insufficiency events (estimated glomerular filtration rate [eGFR] ≤30/mL/min/1...
September 19, 2017: Transplantation
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