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intravenous immunoglobulin

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https://www.readbyqxmd.com/read/29036979/-role-of-ash2-absent-small-or-homeotic-like-and-jumonji-domain-containing-protein-3-on-histone-methylation-of-interferon-gamma-gene-and-their-associations-with-vascular-damage-of-kawasaki-disease
#1
J H Mei, G Tang, Q Wang, P Q Wen, M G Xu, D Cui, D L Ma, C Liu, G B Wang
Objective: To investigate the impacts of ash2 (absent, small, or homeotic)-like (Ash2L) and Jumonji domain-containing protein 3 (Jmjd3) on histone methylation of interferon-gamma(IFN-γ) gene and association with vascular damage of Kawasaki disease (KD) in acute phase. Methods: This study was performed among 36 children with KD in acute phase (KD group) and 28 age-matched health children (control group), who were treated or underwent physical examination in our hospital between February 2015 and June 2016. Patients were further divided into KD groups with or without coronary artery lesions (KD-CAL(+) , 16 cases; KD-CAL(-), 20 cases)...
September 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29035131/ri-002-an-intravenous-immunoglobulin-containing-high-titer-neutralizing-antibody-to-rsv-and-other-respiratory-viruses-for-use-in-primary-immunodeficiency-disease-and-other-immune-compromised-populations
#2
Richard L Wasserman, Benjamin N Greener, James Mond
Novel immune globulin (IG) products (RI-002, RI-001) have been designed to provide protection against respiratory syncytial virus (RSV) mediated respiratory illness while at the same time meeting the manufacturing requirements established by FDA for antibody supplementation in immunocompromised subjects. Areas covered: This review covers the manufacture and development of both RI-001 and RI-002, including the selection of plasma donors for IG preparation with high-titers of anti-RSV antibody, in vitro, and preclinical data in the cotton rat model S...
October 16, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29032734/gammaplex-%C3%A2-5-and-10-in-the-treatment-of-primary-immunodeficiency-and-chronic-immune-thrombocytopenic-purpura
#3
Richard L Wasserman
Immunoglobulin G is used to both prevent infection in primary immunodeficiency diseases (PIDs) and prevent bleeding in immune thrombocytopenic purpura. Gammaplex is a highly purified human intravenous immunoglobulin G available as 5 and 10% liquid formulations. Gammaplex 5% has proven efficacy and safety in PID and immune thrombocytopenic purpura, protecting against serious acute bacterial infections and treating bleeding by improving platelet counts, respectively. The therapeutic effect of Gammaplex 10% is expected to be similar to that of Gammaplex 5% based on demonstrated bioequivalence in a bridging study in PID...
October 2017: Immunotherapy
https://www.readbyqxmd.com/read/29031222/apolipoproteins-adsorption-and-brain-targeting-evaluation-of-baicalin-nanocrystals-modified-by-combination-of-tween80-and-tpgs
#4
Yang Liu, Yueqin Ma, Junnan Xu, Yingchong Chen, Jin Xie, Pengfei Yue, Qin Zheng, Ming Yang
To help baicalin pass across BBB and improve its targeting in brain, we designed a novel formulation strategy of baicalin nanocrystals that preferentially adsorbing apolipoprotein E (ApoE) and repelling protein adsorption of opsonins. Intravenous baicalin nanocrystals suspensions (BCL-NS) modified by different surfactant were prepared by high-pressure homogenization. The targeting potential of surface-modified BCL-NS with mean particles size of about 250nm was assessed by in vitro protein adsorption studies using two-dimensional polyacrylamide gel electrophoresis (2-D PAGE), and further evaluated in vivo pharmacokinetics...
October 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29030251/intravenous-immunoglobulin-ivig-treatment-modulates-peripheral-blood-th17-and-regulatory-t-cells-in-recurrent-miscarriage-patients-non-randomized-open-label-clinical-trial
#5
Majid Ahmadi, Sanaz Abbaspour Aghdam, Mohammad Nouri, Zohreh Babaloo, Laya Farzadi, Aliye Ghasemzadeh, Kobra Hamdi, Ali Akbar Movassaghpour, Farhad Jadidi-Niaragh, Amir Afkham, Morteza Motallebnezhad, Shadi Eghbal-Fard, Sanam Dolati, Vahid Younesi, Mehdi Yousefi
BACKGROUND: Th17 cells and Treg cells have been proposed as new risk factors for recurrent miscarriage (RM). In this study, we investigated the effect of Intravenous immunoglobulin G (IVIG) on the levels and function of Th17 and Treg cells and pregnancy outcome in women with RM. MATERIALS AND METHODS: 94 pregnant women with RM were enrolled in this study. Blood was drawn at the time of positive pregnancy. On the same day, IVIG 400mg/kg was administered intravenously for 44 patients...
October 10, 2017: Immunology Letters
https://www.readbyqxmd.com/read/29028117/comparison-of-weight-based-dosing-strategies-for-intravenous-immunoglobulin-in-patients-with-hematologic-malignancies
#6
Sarah E Stump, Allison J Schepers, Alexis R Jones, Maurice D Alexander, Jessica J Auten
STUDY OBJECTIVE: Intravenous immunoglobulin (IVIG) is a weight-based therapy used to treat and prevent infections in patients with hematologic malignancies. Traditionally, IVIG doses have been calculated using actual body weight (ABW). However, limited pharmacokinetic (PK) data suggest dosing strategies using ideal body weight (IBW) or adjusted body weight (adjBW) may be appropriate given the small volume of distribution of IVIG. The objective of this study was to compare the effectiveness of using a precision-dosing strategy (IBW or adjBW) to a traditional-dosing strategy (ABW) for IVIG in patients with hematologic malignancies or those undergoing hematopoietic stem cell transplant, as well as to perform an IVIG drug use analysis...
October 13, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29027647/dasatinib-associated-reversible-demyelinating-peripheral-polyneuropathy-in-a-case-of-chronic-myeloid-leukemia
#7
Takashi Ishida, Naoyuki Akagawa, Tomomi Miyata, Naomi Tominaga, Takahiro Iizuka, Masaaki Higashihara, Takahiro Suzuki, Koji Miyazaki
Tyrosine kinase inhibitors (TKIs) are essential for the treatment of chronic myeloid leukemia (CML). Adverse effects of dasatinib have been reported; however, few reports have highlighted the association between dasatinib and demyelinating peripheral neuropathy (DPN). We report a patient with CML who developed acute onset of DPN associated with dasatinib therapy. A 46-year-old Japanese woman was treated with dasatinib for 7 months after the diagnosis of CML and she achieved a major molecular response (MMR)...
October 13, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/29026864/gastroparesis-as-the-sole-presenting-feature-of-neuromyelitis-optica
#8
Ahmed Salahudeen, Tejal Mistry
A 33-year-old African-American woman recently diagnosed with severe idiopathic gastroparesis was readmitted for hypoxic respiratory failure secondary to aspiration pneumonia. A fiber-optic endoscopic evaluation of swallow study revealed severe pharyngeal dysphagia. Brain magnetic resonance imaging showed an ill-defined lesion in the posterior aspect of the medulla concerning for a demyelinating process. Serum neuromyelitis optica immunoglobulin G returned positive. Neuromyelitis optica treatment resulted in the patient's clinical improvement...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29026634/hiv-positive-patient-with-gbs-like-syndrome
#9
Samantha J Shepherd, Heather Black, Emma C Thomson, Rory N Gunson
Introduction. Guillain-Barré Syndrome (GBS) is an acute demyelinating polyneuropathy which can occur post-infection. Criteria of diagnosis of GBS include areflexia with progressive bilateral weakness in arms and legs. GBS can lead to severe respiratory and cardiac complications. The fatality rate can be up to 5 % in patients, depending on the severity of the symptoms. HIV can cause a range of neurological disorders including, on rare occasions, GBS. GBS can occur at any stage of HIV infection, highlighting the complexity of diagnosis of GBS within HIV patients...
August 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29026268/characteristic-clinical-features-of-adipsic-hypernatremia-patients-with-subfornical-organ-targeting-antibody
#10
Akari Nakamura-Utsunomiya, Takeshi Y Hiyama, Satoshi Okada, Masaharu Noda, Masao Kobayashi
Adipsic hypernatremia is a rare disease presenting as persistent hypernatremia with disturbance of thirst regulation and hypothalamic dysfunction. As a result of congenital disease, tumors, or inflammation, most cases are accompanied by structural abnormalities in the hypothalamic-pituitary area. While cases with no hypothalamic-pituitary structural lesion have been reported, their etiology has not been elucidated. Recently, we reported three patients with adipsic hypernatremia whose serum-derived immunoglobulin (Ig) specifically reacted with mouse subfornical organ (SFO) tissue...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29025760/prediction-for-intravenous-immunoglobulin-resistance-by-using-weighted-genetic-risk-score-identified-from-genome-wide-association-study-in-kawasaki-disease
#11
Ho-Chang Kuo, Henry Sung-Ching Wong, Wei-Pin Chang, Ben-Kuen Chen, Mei-Shin Wu, Kuender D Yang, Kai-Sheng Hsieh, Yu-Wen Hsu, Shih-Feng Liu, Xiao Liu, Wei-Chiao Chang
BACKGROUND: Intravenous immunoglobulin (IVIG) is the treatment of choice in Kawasaki disease (KD). IVIG is used to prevent cardiovascular complications related to KD. However, a proportion of KD patients have persistent fever after IVIG treatment and are defined as IVIG resistant. METHODS AND RESULTS: To develop a risk scoring system based on genetic markers to predict IVIG responsiveness in KD patients, a total of 150 KD patients (126 IVIG responders and 24 IVIG nonresponders) were recruited for this study...
October 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29023507/massive-immune-response-against-ivig-interferes-with-response-against-other-antigens-in-mice-a-new-mode-of-action
#12
Laetitia Sordé, Sebastian Spindeldreher, Ed Palmer, Anette Karle
Administration of high dose intravenous immunoglobulin (IVIg) is widely used in the clinic to treat autoimmune and severe inflammatory diseases. However, its mechanisms of action remain poorly understood. We assessed the impact of IVIg on immune cell populations using an in vivo ovalbumin (Ova)-immunization mouse model. High dose IVIg significantly reduced the Ova-specific antibody response. Intriguingly, the results obtained indicate an immediate and massive immune reaction against IVIg, as shown by the activation and expansion of B cells and CD4+ T cells in the spleen and draining lymph nodes and the production of IVIg-specific antibodies...
2017: PloS One
https://www.readbyqxmd.com/read/29020871/tolerability-and-safety-of-the-intravenous-immunoglobulin-octagam-%C3%A2-10-in-patients-with-immune-thrombocytopenia-a-post-authorisation-safety-analysis-of-two-non-interventional-phase-iv-trials
#13
Stefan Wietek, Daniel Svorc, Anette Debes, Tor-Einar Svae
OBJECTIVES: To provide detailed data on the tolerability and safety of octagam(®) 10%, a ready-to-use intravenous immunoglobulin, in a subgroup of patients with immune thrombocytopenia (ITP) involved in an integrated analysis of post-authorisation safety surveillance (PASS) studies. METHODS: A subgroup analysis was conducted using data collected from two non-interventional studies that included patients with ITP treated with octagam(®) 10%. Patients were observed and monitored for possible adverse drug reactions (ADRs) during or after administration of octagam(®) 10%, with a particular focus on thromboembolic events (TEEs)...
October 11, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28990325/predominance-of-neutrophils-in-the-cerebrospinal-fluid-of-patients-treated-with-intravenous-immunoglobulin
#14
Andrew A Renshaw, Edwin W Gould
Patients treated with intravenous immunoglobulin can present with numerous neutrophils in the cerebrospinal fluid.
October 9, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28982346/mog-antibody-seropositivity-in-a-patient-with-encephalitis-beyond-the-classical-syndrome
#15
Sara Mariotto, Salvatore Monaco, Patrick Peschl, Ilaria Coledan, Romualdo Mazzi, Romana Höftberger, Markus Reindl, Sergio Ferrari
BACKGROUND: The presence of circulating anti-myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) has been described in sera of patients with different inflammatory conditions of the central nervous system. In adults the core clinical feature is usually characterised by acute myelitis and/or optic neuritis. We here report an atypical case with serum and cerebrospinal fluid MOG-Abs and a clinical picture suggestive for acute encephalitis. CASE PRESENTATION: A 31-year-old Indian man presented with altered mental status, slight fever, and ataxia...
October 5, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28980088/rituximab-in-clinical-practice-dosage-drug-adherence-ig-levels-infections-and-drug-antibodies
#16
Jon Thorkell Einarsson, Max Evert, Pierre Geborek, Tore Saxne, Maria Lundgren, Meliha C Kapetanovic
The objective of this study is to explore the following: (1) the impact of two different initial doses and cumulative 2-year dose of rituximab (RTX) on drug adherence and predictors of adherence to treatment in rheumatoid arthritis (RA) patients in an observational clinical setting, (2) immunoglobulin levels (IgG/IgM/IgA) during repeated treatment and their relation to infections, and (3) development of anti-rituximab antibodies (ADA). All RA patients receiving RTX from January 2003 to April 2012 at the department were included...
October 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28978600/bilateral-large-subconjunctival-haemorrhages-unmasking-immune-thrombocytopenic-purpura-during-retinopathy-of-prematurity-screening
#17
Parijat Chandra, Devesh Kumawat, Vinod Kumar, Ruchir Tewari
Although thrombocytopenia is known to be associated with pathogenesis of retinopathy of prematurity (ROP), immune thrombocytopenic purpura (ITP) is rare in infancy and not reported to occur with ROP. A preterm infant with aggressive posterior ROP developed bilateral massive subconjunctival haemorrhage after scleral indentation during screening. On evaluation, the infant was found to have severe ITP. Following intravenous transfusion of platelets and immunoglobulin, platelet counts improved and subconjunctival haemorrhage resolved over time...
October 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28978596/safe-usage-of-anakinra-and-dexamethasone-to-treat-refractory-hemophagocytic-lymphohistiocytosis-secondary-to-acute-disseminated-histoplasmosis-in-a-patient-with-hiv-aids
#18
Anthony J Ocon, Birju D Bhatt, Cynthia Miller, Ruben A Peredo
Hemophagocytic lymphohistiocytosis (HLH) is a serious life-threatening disease if not recognised early. In patients with HIV/AIDS, this association has been reported following acute opportunistic infections, including histoplasmosis. However, optimal treatment is not known. We describe a male aged 46 years with AIDS who developed HLH following acute disseminated histoplasmosis. Presenting symptoms included fever, hepatosplenomegaly and pancytopenia. Bone marrow biopsy confirmed HLH. Initially, he was refractory to the treatment with amphotericin B, antiretroviral therapy and intravenous immunoglobulin (IVIG)...
October 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28977831/epigenetic-hypomethylation-and-upregulation-of-matrix-metalloproteinase-9-in-kawasaki-disease
#19
Ho-Chang Kuo, Sung-Chou Li, Lien-Hung Huang, Ying-Hsien Huang
BACKGROUND: Kawasaki disease (KD) is a type of febrile coronary vasculitis occurring in children. Some researchers have suggested that changes in genetic signatures, such as matrix metalloproteinases (MMPs), are critical markers for cardiovascular diseases. This study aims to provide a comprehensive survey of global DNA methylation levels and MMP transcripts of KD patients compared to control subjects. MATERIALS AND METHODS: For chips studies, we recruited a total of 18 KD patients, prior to receiving intravenous immunoglobulin (IVIG) and at least 3 weeks after IVIG treatment, as well as 18 healthy and 18 febrile control subjects...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28975137/rapid-resolution-of-enterovirus-71-associated-opsoclonus-myoclonus-syndrome-on-intravenous-immunoglobulin
#20
Ahmed Sahly, Laurence Gauquelin, Guillaume Sébire
Nonparaneoplastic opsoclonus-myoclonus ataxia syndrome is a rare neuroinflammatory condition featured by opsoclonus, myoclonus, ataxia, and cognitive behavioral disturbance. The authors report an observation of enterovirus 71-associated opsoclonus-myoclonus ataxia syndrome evolving toward full recovery on intravenous intravenous immunoglobulin (IG) treatment. Based on this case report, enterovirus 71 should be added to the list of infectious agents likely involved in opsoclonus-myoclonus ataxia syndrome, including the emerging subgroup of opsoclonus-myoclonus ataxia syndrome recovering without aggressive or prolonged immunosuppressive intervention...
January 2017: Child neurology open
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