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https://www.readbyqxmd.com/read/28542340/no-evidence-that-migratory-geese-disperse-avian-influenza-viruses-from-breeding-to-wintering-ground
#1
Shenglai Yin, David Kleijn, Gerard J D M Müskens, Ron A M Fouchier, Josanne H Verhagen, Petr M Glazov, Yali Si, Herbert H T Prins, Willem Frederik de Boer
Low pathogenic avian influenza virus can mutate to a highly pathogenic strain that causes severe clinical signs in birds and humans. Migratory waterfowl, especially ducks, are considered the main hosts of low pathogenic avian influenza virus, but the role of geese in dispersing the virus over long-distances is still unclear. We collected throat and cloaca samples from three goose species, Bean goose (Anser fabalis), Barnacle goose (Branta leucopsis) and Greater white-fronted goose (Anser albifrons), from their breeding grounds, spring stopover sites, and wintering grounds...
2017: PloS One
https://www.readbyqxmd.com/read/28539661/the-pb2-mutation-with-lysine-at-627-enhances-the-pathogenicity-of-avian-influenza-h7n9-virus-which-belongs-to-a-non-zoonotic-lineage
#2
Weixuan Li, Horace Hok Yeung Lee, Run Feng Li, Huachen Maria Zhu, Guan Yi, Joseph Sriyal Malik Peiris, Zi Feng Yang, Chris Ka Pun Mok
A novel avian-origin influenza A (H7N9) virus emerged in China in 2013 and has caused zoonotic disease in over 1123 persons with an overall mortality around 30%. Amino acid changes at the residues 591, 627 and 701 of polymerase basic protein 2 (PB2) have been found frequently in the human H7N9 isolates but not in viruses isolated from avian species. We have recently identified a cluster of H7N9 viruses in ducks which circulated in China prior to the first recognition of zoonotic disease in 2013. These duck viruses have genetic background distinct from the zoonotic H7N9 lineage...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28530771/macrophage-migration-inhibitory-factor-levels-correlate-with-an-infection-in-trauma-patients
#3
Young Duck Cho, Sung Hyuk Choi, Jung Youn Kim, Sung Jun Park, Young Hoon Yoon, Han Jin Cho, Ji Won Yeom
BACKGROUND: The role of migration inhibitory factor (MIF) is best understood in septic shock and septic disease; however, the role of MIF in a secondary infection after trauma has not yet been completely studied. This study aimed to evaluate the role of MIF in trauma patients. METHODS: The patients in the study population were divided into two groups according to the results of their MIF levels. The initial MIF levels, trauma mechanism, revised trauma score, survival rate, length of stay (LOS) in the intensive care unit (ICU), level of leukocytes, and level of C-reactive protein (CRP) were compared between the groups...
May 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28525340/detection-of-bordetella-avium-by-taqman-real-time-pcr-in-tracheal-swabs-from-wildlife-birds
#4
T Stenzel, D Pestka, B Tykałowski, M Śmiałek, A Koncicki, A Bancerz-Kisiel
Bordetella avium, the causing agent of bordetellosis, a highly contagious infection of the respiratory tract in young poultry, causes significant losses in poultry farming throughout the world. Wildlife birds can be a reservoir of various pathogens that infect farm animals. For this reason the studies were conducted to estimate the prevalence of Bordetella avium in wildlife birds in Poland. Tracheal swab samples were collected from 650 birds representing 27 species. The bacterial DNA was isolated directly from the swabs and screened for Bordetella avium by TaqMan real-time PCR...
March 28, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28516729/proteome-analysis-of-duck-tembusu-virus-dtmuv-infected-bhk-21-cells
#5
Xin Sun, Shengyu Wang, Xian Lin, Lianzhong Zhao, Dan Zhang, Chenyang Yi, Xiaomei Sun, Huanchun Chen, Meilin Jin
Duck Tembusu virus (DTMUV) is a newly emerging pathogenic flavivirus that has caused huge economic losses to the duck industry in China since 2010. Moreover, the infection has spread rapidly, posing a potential public health concern. In this study, iTRAQ approach was firstly used to quantitatively identify differentially expressed cellular proteins in DTMUV-infected BHK-21 cells which are usually employed to produce veterinary vaccines for DTMUV, as well as other flaviviruses by serial passage. We identified 192 differentially expressed cellular proteins, including 11 upregulated and 8 downregulated proteins at 24 h postinfection (hpi), as well as 25 upregulated and 151 downregulated proteins at 48 hpi, of which TLR9, DDX3X, and DDX5 may play important roles in virus propagation...
May 17, 2017: Proteomics
https://www.readbyqxmd.com/read/28513330/the-pathogenesis-of-clade-2-3-4-4-h5-highly-pathogenic-avian-influenza-viruses-in-ruddy-duck-oxyura-jamaicensis-and-lesser-scaup-aythya-affinis
#6
Erica Spackman, Diann J Prosser, Mary J Pantin-Jackwood, Alicia M Berlin, Christopher B Stephens
Waterfowl are the natural hosts of avian influenza virus (AIV) and disseminate the virus worldwide through migration. Historically, surveillance and research efforts for AIV in waterfowl have focused on dabbling ducks. The role of diving ducks in AIV ecology has not been well characterized. In this study, we examined the relative susceptibility and pathogenicity of clade 2.3.4.4 H5 highly pathogenic (HP) AIV (HPAIV) in two species of diving ducks. Juvenile and adult Ruddy Duck (Oxyura jamaicensis) and juvenile Lesser Scaup (Aythya affinis) were intranasally inoculated with A/Northern Pintail/WA/40964/2014 H5N2 HPAIV...
May 17, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28501472/prokaryotic-expression-of-a-codon-optimized-capsid-gene-from-duck-circovirus-and-its-application-to-an-indirect-elisa
#7
Cui Yang, Yu Xu, Renyong Jia, Pengfei Li, Lei Zhang, Mingshu Wang, Dekang Zhu, Shun Chen, Mafeng Liu, Zhongqiong Yin, Anchun Cheng
Duck circovirus (DuCV), as a causative agent of long-term immunosuppressive disease, has caused heavy damage to waterfowl breeding worldwide. In this study, the full-length Cap (capsid) gene of DuCV was expressed in Escherichia coli (E. coli) for the first time by optimizing the codons in its nuclear localization signal (NLS) regions. The recombinant protein was expressed as inclusion bodies, and the quantification of purified Cap protein could reach 0.29mgmL(-1). Moreover, an indirect ELISA method (Cap-ELISA) was established based on the recombinant Cap protein...
May 10, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28498306/a-conserved-residue-tyrosine-y-84-in-h5n1-influenza-a-virus-ns1-regulates-ifn-signaling-responses-to-enhance-viral-infection
#8
Ben X Wang, Lianhu Wei, Lakshmi P Kotra, Earl G Brown, Eleanor N Fish
The non-structural protein, NS1, is a virulence factor encoded by influenza A viruses (IAVs). In this report, we provide evidence that the conserved residue, tyrosine (Y) 84, in a conserved putative SH2-binding domain in A/Duck/Hubei/2004/L-1 [H5N1] NS1 is critical for limiting an interferon (IFN) response to infection. A phenylalanine (F) substitution of this Y84 residue abolishes NS1-mediated downregulation of IFN-inducible STAT phosphorylation, and surface IFNAR1 expression. Recombinant IAV (rIAV) [H1N1] expressing A/Grey Heron/Hong Kong/837/2004 [H5N1] NS1-Y84F (rWSN-GH-NS1-Y84F) replicates to lower titers in human lung epithelial cells and is more susceptible to the antiviral effects of IFN-β treatment compared with rIAV expressing the intact H5N1 NS1 (rWSN-GH-NS1-wt)...
May 12, 2017: Viruses
https://www.readbyqxmd.com/read/28490598/development-of-clade-specific-and-broadly-reactive-live-attenuated-influenza-virus-vaccines-against-rapidly-evolving-h5-subtype-viruses
#9
Kobporn Boonnak, Yumiko Matsuoka, Weijia Wang, Amorsolo L Suguitan, Zhongying Chen, Myeisha Paskel, Mariana Baz, Ian Moore, Hong Jin, Kanta Subbarao
We have developed pandemic live attenuated influenza vaccines (pLAIV) against clade 1 H5N1 viruses on an Ann Arbor cold-adapted (ca) backbone that induced long-term immune memory. In 2015, many human infections caused by a new clade (2.2.1.1) of goose/Guangdong (gs/GD) lineage H5N1 viruses were reported in Egypt that prompted updating of the H5N1 pLAIV. We explored two strategies to generate suitable pLAIVs: first to modify the hemagglutinin gene of a highly pathogenic wild-type (wt) clade 2.2.1.1 virus A/Egypt/N03434/2009 (Egy/09) (H5N1) with its unmodified neuraminidase (NA) gene; this virus was designated Egy/09 ca The second approach was to select a low pathogenicity avian influenza H5 virus that elicited antibodies that cross-reacted with a broad range of H5 viruses, including the Egypt H5N1 viruses and contained a novel NA subtype for humans...
May 10, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28490583/structural-definition-of-duck-mhc-class-i-molecules-that-might-explain-efficient-ctl-immunity-against-influenza-a-virus
#10
Yanan Wu, Junya Wang, Shuhua Fan, Rong Chen, Yanjie Liu, Jianhua Zhang, Hongyu Yuan, Ruiying Liang, Nianzhi Zhang, Chun Xia
A single dominantly expressed allele of the major histocompatibility complex class I (MHC I) may be responsible for the duck's high tolerance to the highly pathogenic (HP) influenza A virus (IAV) compared to the chicken's lower tolerance. In this study, the crystal structures of duck MHC I (Anpl-UAA*01) and duck β2m with two peptides from the H5N1 strains were determined, respectively. Two remarkable features were found to distinguish the Anpl-UAA*01 complex from other known MHC I structures. A disulfide bond formed by Cys(95) and Cys(112) and connecting the β5 and β6 sheets at the bottom of peptide binding groove (PBG) in Anpl-UAA*01 complex, which can enhance IAV peptides binding, was identified...
May 10, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28484437/a-novel-raym_rs09735-raym_rs09740-two-component-signaling-system-regulates-gene-expression-and-virulence-in-riemerella-anatipestifer
#11
Ying Wang, Ti Lu, Xuehuan Yin, Zutao Zhou, Shaowen Li, Mei Liu, Sishun Hu, Dingren Bi, Zili Li
The Gram-negative bacterium Riemerella anatipestifer is an important waterfowl pathogen, causing major economic losses to the duck-producing industry. However, little is known of the virulence factors that mediate pathogenesis during R. anatipestifer infection. In this study, RAYM_RS09735 and RAYM_RS09740 were predicted to form a two-component signaling system (TCS) through bioinformatics analysis. This TCS was highly conserved across the Flavobacteriaceae. A mutant YMΔRS09735/RS09740 strain was constructed to investigate the role of the RAYM_RS09735/RAYM_RS09740 TCS in R...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28481913/tropism-and-infectivity-of-duck-derived-egg-drop-syndrome-virus-in-chickens
#12
Min Kang, Se-Yeoun Cha, Hyung-Kwan Jang
Egg drop syndrome virus (EDSV) can markedly decrease egg production in laying hens. Duck is the natural host of EDSV. EDSV derived from ducks abrogate egg drop in laying hens. We have previously confirmed that duck-derived EDSVs have a variety of replication activities in chick embryo liver (CEL) cells. However, it is currently unclear whether duck-derived EDSV could display tropism and adaptation in laying hens. This study assessed whether duck-derived EDSV can adapt to laying hens, and estimated the inducing factors...
2017: PloS One
https://www.readbyqxmd.com/read/28475626/the-ecology-of-avian-influenza-viruses-in-wild-dabbling-ducks-anas-spp-in-canada
#13
Zsuzsanna Papp, Robert G Clark, E Jane Parmley, Frederick A Leighton, Cheryl Waldner, Catherine Soos
Avian influenza virus (AIV) occurrence and transmission remain important wildlife and human health issues in much of the world, including in North America. Through Canada's Inter-Agency Wild Bird Influenza Survey, close to 20,000 apparently healthy, wild dabbling ducks (of seven species) were tested for AIV between 2005 and 2011. We used these data to identify and evaluate ecological and demographic correlates of infection with low pathogenic AIVs in wild dabbling ducks (Anas spp.) across Canada. Generalized linear mixed effects model analyses revealed that risk of AIV infection was higher in hatch-year birds compared to adults, and was positively associated with a high proportion of hatch-year birds in the population...
2017: PloS One
https://www.readbyqxmd.com/read/28473814/avian-interferon-inducible-transmembrane-protein-family-effectively-restricts-avian-tembusu-virus-infection
#14
Shilong Chen, Long Wang, Jieying Chen, Lanlan Zhang, Song Wang, Mohsan U Goraya, Xiaojuan Chi, Yang Na, Wenhan Shao, Zhou Yang, Xiancheng Zeng, Shaoying Chen, Ji-Long Chen
Avian Tembusu virus (ATMUV) is a highly pathogenic flavivirus that causes significant economic losses to the Chinese poultry industry. Our previous experiments demonstrated that ATMUV infection effectively triggered host innate immune response through MDA5 and TLR3-dependent signaling pathways. However, little information is available on the role of interferon-stimulated genes (ISGs) in defending against ATMUV infection. In this study, we found that ATMUV infection induced robust expression of type I and type III interferon (IFNs) in duck tissues...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28469192/construction-of-a-highly-efficient-crispr-cas9-mediated-duck-enteritis-virus-based-vaccine-against-h5n1-avian-influenza-virus-and-duck-tembusu-virus-infection
#15
Zhong Zou, Kun Huang, Yanmin Wei, Huanchun Chen, Ziduo Liu, Meilin Jin
Duck enteritis virus (DEV), duck tembusu virus (DTMUV), and highly pathogenic avian influenza virus (HPAIV) H5N1 are the most important viral pathogens in ducks, as they cause significant economic losses in the duck industry. Development of a novel vaccine simultaneously effective against these three viruses is the most economical method for reducing losses. In the present study, by utilizing a clustered regularly interspaced short palindromic repeats (CRISPR)/associated 9 (Cas9)-mediated gene editing strategy, we efficiently generated DEV recombinants (C-KCE-HA/PrM-E) that simultaneously encode the hemagglutinin (HA) gene of HPAIV H5N1 and pre-membrane proteins (PrM), as well as the envelope glycoprotein (E) gene of DTMUV, and its potential as a trivalent vaccine was also evaluated...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28455254/effects-of-chrysanthemum-indicum-polysaccharide-and-its-phosphate-on-anti-duck-hepatitis-a-virus-and-alleviating-hepatic-injury
#16
Ke Ming, Yun Chen, Jintong Shi, Jingjing Yang, Fangke Yao, Hongu Du, Wei Zhang, Jingying Bai, Jiaguo Liu, Deyun Wang, Yuanliang Hu, Yi Wu
To explore new effective anti-duck hepatitis A virus drugs, Chrysanthemum indicum polysaccharide (CIPS) was phosphorylation modified using STMP-STPP method, and phosphorylated Chrysanthemum indicum polysaccharide (pCIPS) was obtained. Characteristic absorption peaks were observed in pCIPS using IR spectrum, suggested that CIPS was successfully modified. In addition, field emission scanning electron micro-scope (FE-SEM) was used to observe the polysaccharides' surface features. In vitro, we found that the survival rate of DHAV-infected hepatocytes increased after the two drugs treatment, indicated that the two drugs possess good anti-DHAV activity...
April 26, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28453859/temporal-and-spatial-characteristics-of-highly-pathogenic-avian-influenza-outbreaks-in-china-during-2004-to-2015
#17
Mingyue Liu, Qian Lu, Shuxia Zhang, Xiaolong Feng, Md Shakhawat Hossain
Identifying the temporal and spatial characteristics of highly pathogenic avian influenza (HPAI) outbreaks is very important for developing effective and appropriate countermeasures against HPAI and promoting sustainable development in the poultry industry. This study aimed to analyze four aspects of the temporal and spatial characteristics of HPAI outbreaks in China, including the frequency of HPAI outbreaks, numbers of dead animals (died or culled), types of HPAI viruses, and species of infected animals. Temporal characteristics showed that the frequency of HPAI outbreaks decreased and then increased, with some years deviating from the main trend in 2004 to 2010 and 2011 to 2015, while the largest number of dead animals due to HPAI outbreaks was in 2005...
April 26, 2017: Poultry Science
https://www.readbyqxmd.com/read/28445657/aquatic-bird-bornavirus-associated-disease-in-free-living-canada-geese-branta-canadensis-in-the-northeastern-united-states
#18
Maureen Murray, Jianhua Guo, Ian Tizard, Samuel Jennings, H L Shivaprasad, Susan Payne, Julie C Ellis, Arnaud J Van Wettere, Kathleen M O'Brien
During the winter of 2013-14, 22 Canada geese ( Branta canadensis ) were admitted to the Wildlife Clinic at the Cummings School of Veterinary Medicine at Tufts University with nonspecific neurologic abnormalities and emaciation. Five of these geese, along with three geese that were submitted dead, were evaluated via histopathology, immunohistochemistry, and reverse transcription PCR (RT-PCR) for bornaviruses. Histopathologically, six of the eight birds had lymphoplasmacytic encephalitis. One bird, which also had encephalitis, had a dilated esophagus...
April 26, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28442426/identification-of-a-wza-like-gene-involved-in-capsule-biosynthesis-pathogenicity-and-biofilm-formation-in-riemerella-anatipestifer
#19
Haibo Yi, Biao Yuan, Jibin Liu, Dekang Zhu, Ying Wu, Mingshu Wang, Renyong Jia, Kunfeng Sun, Qiao Yang, Shun Chen, Mafeng Liu, Xiaoyue Chen, Anchun Cheng
Duck infectious serositis is the most serious bacterial disease of ducks. It is caused by Riemerella anatipestifer (RA) infection. The capsule plays an important role in virulence of many pathogenic bacteria. In addition, the capsule has some key biological features. However, few studies have explored the characteristics of the RA capsule. In this study, we mainly constructed a capsular mutants of RA by inactivating the wza gene using homologous recombination. We found that the mutant was failed to produce a capsule layer...
April 22, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28435197/development-of-nested-polymerase-chain-reaction-based-diagnosis-of-duck-enteritis-virus-and-detection-of-dna-polymerase-gene-from-non-descriptive-duck-breeds-of-west-bengal-india
#20
Partha Sarathi Mandal, Sunit Kumar Mukhopadhayay, Saktipada Pradhan, Samiran Mondal, Chandrakanta Jana, Nimai Chandra Patra, Rabindra Nath Hansda
AIM: The study was undertaken to detect the clinical signs, postmortem lesions of embryonated duck plague (DP) infected eggs, and histopathological changes of chorioallantoic membrane (CAM) in non-descriptive ducks of West Bengal with special reference to standardize nested polymerase chain reaction (PCR). MATERIALS AND METHODS: After postmortem of suspected carcasses, samples were collected for virus isolation and identification through specific pathogen free (Khaki Campbell) embryonated duck eggs...
March 2017: Veterinary World
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