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https://www.readbyqxmd.com/read/29212927/mutations-in-the-pa-protein-of-avian-h5n1-influenza-viruses-affect-polymerase-activity-and-mouse-virulence
#1
Gongxun Zhong, Mai Quynh Le, Tiago J S Lopes, Peter Halfmann, Masato Hatta, Shufang Fan, Gabriele Neumann, Yoshihiro Kawaoka
To study the influenza viral determinants of pathogenicity, we characterized two highly pathogenic avian H5N1 influenza viruses isolated in Vietnam in 2012 (A/duck/Vietnam/QT1480/2012; QT1480) and 2013 (A/duck/Vietnam/QT1728/2013; QT1728) and found that the activity of their polymerase complexes differed significantly, even though both viruses were highly pathogenic in mice. Further studies revealed that the PA-S343A/E347D mutations reduced viral polymerase activity and mouse virulence when tested in the genetic background of QT1728 virus...
December 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29209053/development-of-an-influenza-virus-protein-microarray-to-measure-the-humoral-response-to-influenza-virus-infection-in-mallards
#2
Philip Meade, Neus Latorre-Margalef, David E Stallknecht, Florian Krammer
Avian influenza viruses pose a serious zoonotic threat, in part because current seasonal influenza virus vaccines only offer strain-specific protection, instead of heterosubtypic or universal protection against influenza virus infection. Understanding the humoral response to vaccination and natural infection in the broadest context possible is important to developing defenses against influenza zoonosis. Protein microarrays are a novel platform well suited to assaying the humoral immune response broadly and efficiently...
December 6, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29203482/presence-of-mcr-3-variant-in-aeromonas-caviae-proteus-mirabilis-and-escherichia-coli-from-one-domestic-duck
#3
Xiaoming Wang, Weishuai Zhai, Jiyun Li, Dejun Liu, Qidi Zhang, Zhangqi Shen, Shaolin Wang, Yang Wang
The rapid rise and dissemination of MDR bacteria is a major threat to public health worldwide, and has narrowed the treatment options for infections caused by these bacteria (1).….
December 4, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29201029/virologic-and-immunologic-characteristics-in-mature-ducks-with-acute-duck-hepatitis-a-virus-1-infection
#4
Sai Mao, Mingshu Wang, Xumin Ou, Di Sun, Anchun Cheng, Dekang Zhu, Shun Chen, Renyong Jia, Mafeng Liu, Kunfeng Sun, Qiao Yang, Ying Wu, Xinxin Zhao, Xiaoyue Chen
Duck hepatitis A virus 1 (DHAV-1) infection in mature ducks has previously been proposed as a small-animal model for human hepatitis A. However, basic research on the outcome of DHAV-1 infection in mature ducks is limited. Here, we examined the course of viremia, the characteristics of antibody responses, and the profiles of plasma cytokines in mature ducks infected with DHAV-1. During the course of infection, the viremia was detectable soon after infection and persisted for 196 days, however, the ducks presented as clinically asymptomatic...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29186963/molecular-epidemiology-and-genetic-diversity-of-duck-hepatitis-a-virus-type-3-in-shandong-province-of-china-2012-2014
#5
R Zhang, L Xia, J Chen, Y Gong, L Zhang, P Li, H Liu, Z Xie, S Jiang
 The infections with duck hepatitis A virus type 3 (DHAV-3) become common in eastern Asia. To better understand the molecular evolution and genetic variation of DHAV-3, a total of 482 dead Cherry Valley duckling liver samples collected from Shandong province of China during 2012-2014 were tested, and the complete P1 coding sequences of 18 DHAV-3 strains were analyzed. The detection rate of DHAV-3 was 64.5% (311/482) in clinical liver samples and 73.0% (92/126) in duckling flocks. The P1 genes of the 18 DHAV-3 isolates shared 91...
2017: Acta Virologica
https://www.readbyqxmd.com/read/29183746/assessment-of-the-anti-snakebite-properties-of-extracts-of-aniba-fragrans-ducke-lauraceae-used-in-folk-medicine-as-complementary-treatment-in-cases-of-envenomation-by-bothrops-atrox
#6
Valéria Mourão de Moura, Noranathan da Costa Guimarães, Luana Travassos Batista, Luciana A Freitas-de-Sousa, Joanderson de Sousa Martins, Maria Carolina Scheffer de Souza, Patrícia D Oliveira de Almeida, Wuelton Marcelo Monteiro, Ricardo Bezerra de Oliveira, Maria Cristina Dos-Santos, Rosa Helena Veras Mourão
ETHNOPHARMACOLOGICAL RELEVANCE: Extracts of leaves and bark of Aniba fragrans are used as tea (decoction) to treat snakebites in communities in the Brazilian Amazon. The aqueous extract of the leaves of A. fragrans has been proven to be effective against Bothrops venom, but only when pre-incubated with the venom. This study sought to assess the potential of different types of extract of this species to inhibit the biological activities of Bothrops atrox venom (BaV) when used the same way as in folk medicine...
November 25, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29176600/cleavage-of-poly-a-binding-protein-by-duck-hepatitis-a-virus-3c-protease
#7
Di Sun, Mingshu Wang, Xingjian Wen, Anchun Cheng, Renyong Jia, Kunfeng Sun, Qiao Yang, Ying Wu, Dekang Zhu, Shun Chen, Mafeng Liu, Xinxin Zhao, Xiaoyue Chen
During viral infections, some viruses subvert the host proteins to promote the translation or RNA replication with their protease-mediated cleavage. Poly (A)-binding protein (PABP) is a target for several RNA viruses; however, the impact of duck hepatitis A virus (DHAV) on PABP remains unknown. In this study, we demonstrated for the first time that DHAV infection stimulates a decrease in endogenous PABP and generates two cleavage fragments. On the basis of in vitro cleavage assays, an accumulation of PABP cleavage fragments was detected in duck embryo fibroblast (DEF) cell extracts incubated with functional DHAV 3C protease...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29174810/design-synthesis-and-biological-evaluation-of-new-1-2-3-triazolo-2-deoxy-2-fluoro-4-azido-nucleoside-derivatives-as-potent-anti-hbv-agents
#8
Yuan Liu, Youmei Peng, Jingjing Lu, Jingwen Wang, Haoran Ma, Chuanjun Song, Bingjie Liu, Yan Qiao, Wenquan Yu, Jie Wu, Junbiao Chang
Novel drugs are urgently needed to combat hepatitis B virus (HBV) infection due to drug-resistant virus. In this paper, a series of novel 4-monosubstituted 2'-deoxy-2'-β-fluoro-4'-azido-β-d-arabinofuranosyl 1,2,3-triazole nucleoside analogues (1a-g) were designed, synthesized and screened for in vitro anti-HBV activity. At 5.0 μM in the cellular model, all the synthetic compounds display activities comparable to that of the positive control, lamivudine at 20 μM. Of the compounds tested, the amide-substituted analogue (1a) shows the most promising anti-HBV activity and low cytotoxicity in the cell model...
November 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29173586/differential-immune-related-gene-expression-in-the-spleens-of-duck-tembusu-virus-infected-goslings
#9
Yu He, Anqi Wang, Shun Chen, Zhen Wu, Jinyue Zhang, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Qiao Yang, Ying Wu, Kunfeng Sun, Xiaoyue Chen, Anchun Cheng
Flaviviruses pose a significant threat to public health worldwide. Recently, a novel flavivirus, duck Tembusu virus (TMUV), was identified as the causative agent of a serious duck viral disease in Asia. Its rapid spread and expanded host range have raised substantial concerns regarding its potential threat to non-avian hosts, including humans. However, the specific molecular host responses to this virus are poorly understood. In this study, we used the RNA-sequencing technique to analyse the differential gene expression in the spleens of infected goslings 5days post-infection...
December 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29167239/complete-genome-sequence-of-the-novel-bacteriophage-psco-10-infecting-staphylococcus-cohnii
#10
Jin Woo Jun, Sib Sankar Giri, Hyoun Joong Kim, Cheng Chi, Saekil Yun, Sang Guen Kim, Sang Wha Kim, Jeong Woo Kang, Se Chang Park
Herein, we report the complete genome sequence of the Staphylococcus Myoviridae phage pSco-10 infecting Staphylococcus cohnii The phage pSco-10 was isolated from duck feces collected from four farms in South Korea. The current report provides valuable information for genomic study of phages.
November 22, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29151586/h7n9-virulent-mutants-detected-in-chickens-in-china-pose-an-increased-threat-to-humans
#11
Jianzhong Shi, Guohua Deng, Huihui Kong, Chunyang Gu, Shujie Ma, Xin Yin, Xianying Zeng, Pengfei Cui, Yan Chen, Huanliang Yang, Xiaopeng Wan, Xiurong Wang, Liling Liu, Pucheng Chen, Yongping Jiang, Jinxiong Liu, Yuntao Guan, Yasuo Suzuki, Mei Li, Zhiyuan Qu, Lizheng Guan, Jinkai Zang, Wenli Gu, Shuyu Han, Yangming Song, Yuzhen Hu, Zeng Wang, Linlin Gu, Wenyu Yang, Libin Liang, Hongmei Bao, Guobin Tian, Yanbing Li, Chuanling Qiao, Li Jiang, Chengjun Li, Zhigao Bu, Hualan Chen
Certain low pathogenic avian influenza viruses can mutate to highly pathogenic viruses when they circulate in domestic poultry, at which point they can cause devastating poultry diseases and severe economic damage. The H7N9 influenza viruses that emerged in 2013 in China had caused severe human infections and deaths. However, these viruses were nonlethal in poultry. It is unknown whether the H7N9 viruses can acquire additional mutations during their circulation in nature and become lethal to poultry and more dangerous for humans...
October 24, 2017: Cell Research
https://www.readbyqxmd.com/read/29137226/the-neglected-avian-hepatotropic-virus-induces-acute-and-chronic-hepatitis-in-ducks-an-alternative-model-for-hepatology
#12
Xumin Ou, Sai Mao, Jingyu Cao, Yunchao Ma, Guangpeng Ma, Anchun Cheng, Mingshu Wang, Dekang Zhu, Shun Chen, Renyong Jia, Mafeng Liu, Kunfeng Sun, Qiao Yang, Ying Wu, Xiaoyue Chen
Duck Hepatitis A Virus (DHAV) belongs to the Avihepatovirus, which is also classified into Picornaviridae with Hepatovirus, Hepatitis A Virus (HAV). In humans, the pathogenesis of HAV is not well understood because of limited work with animal models. Here, we investigated the progress of duck viral hepatitis caused by DHAV and their potential for dissecting the pathogenesis of HAV. During the course of infection, the duck model had undergone hepatocellular lesions (vacuolation, acidophilic degeneration and steatosis), lymphocytes recruitment (neutrophil granulocytes, heterophilic granulocytes and T cells or plasm cells) and repair (activation of hepatic stellate cells, fibrosis and regeneration)...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29126900/activity-of-nucleic-acid-polymers-in-rodent-models-of-hbv-infection
#13
Katrin Schöneweis, Neil Motter, Pia L Roppert, Mengji Lu, Baoju Wang, Ingo Roehl, Dieter Glebe, Dongliang Yang, John D Morrey, Michael Roggendorf, Andrew Vaillant
Nucleic acid polymers (NAPs) block the release of HBsAg from infected hepatocytes. These compounds have been previously shown to have the unique ability to eliminate serum surface antigen in DHBV-infected Pekin ducks and achieve multilog reduction of HBsAg or HBsAg loss in patients with chronic HBV infection and HBV/HDV coinfection. In ducks and humans, the blockage of HBsAg release by NAPs occurs by the selective targeting of the assembly and/or secretion of subviral particles (SVPs). The clinically active NAP species REP 2055 and REP 2139 were investigated in other relevant animal models of HBV infection including woodchucks chronically infected with WHV, HBV transgenic mice and HBV infected SCID-Hu mice...
November 8, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29126221/identification-and-characterization-of-mcr-mediated-colistin-resistance-in-extraintestinal-escherichia-coli-from-poultry-and-livestock-in-china
#14
Afrah Kamal Yassin, Jilei Zhang, Jiawei Wang, Li Chen, Patrick Kelly, Patrick Butaye, Guangwu Lu, Jiansen Gong, Min Li, Lanjing Wei, Yaoyao Wang, Kezong Qi, Xiangan Han, Stuart Price, Terri Hathcock, Chengming Wang
Antimicrobial resistance to colistin has emerged worldwide threatening the efficacy of one of the last-resort antimicrobials used for the treatment of multidrug-resistant Enterobacteriaceae infection in humans. In this study, we investigated the presence of colistin resistance genes (mcr-1, mcr-2, mcr-3) in Escherichia coli strains isolated from poultry and livestock collected between 2004 and 2012 in China. Furthermore, we studied the maintenance and transfer of the mcr-1 gene in E. coli after serial passages...
November 8, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29115743/survivability-of-low-pathogenic-h9n2-avian-influenza-virus-in-water-in-the-presence-of-atyopsis-moluccensis-bamboo-shrimp
#15
A P Pathak, H V Murugkar, S Nagarajan, R Sood, C Tosh, M Kumar, C K Athira, A Praveen
Low pathogenic avian influenza virus (LPAIV) exhibits an ecological climax with the aquatic ecosystem. The most widely prevalent subtype of LPAIV is H9N2. Wild aquatic birds being the natural reservoirs and ducks, the "Trojan horses" for Avian Influenza Virus (AIV), can contaminate the natural water bodies inhabited by them. The virus can persist in the contaminated water from days to years depending upon the environmental conditions. Various aquatic species other than ducks can promote the persistence and transmission of AIV; however, studies on the role of aquatic fauna in persistence and transmission of avian influenza virus are scarce...
November 8, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29103688/pathogenicity-of-pekin-duck-and-goose-origin-parvoviruses-in-pekin-ducklings
#16
Kang Ning, Minghang Wang, Shenghua Qu, Junfeng Lv, Lixin Yang, Dabing Zhang
Goose parvovirus (GPV) usually affects goslings and Muscovy ducks but not Pekin ducks. Earlier works showed that a variant GPV can cause short beak and dwarfism syndrome (SBDS) in Pekin ducks. Here, we investigated the pathogenicity of a variant GPV of Pekin duck-origin (JS1) and a classical GPV of goose-origin (H) in Pekin ducklings. Following intramuscular infection at two days of age, both JS1 and H strains influenced weight gain and development of beaks and bones of wings and legs, and caused microscopic lesions of internal organs of ducks...
October 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29100535/construction-and-characterization-of-an-improved-dna-launched-infectious-clone-of-duck-hepatitis-a-virus-type-1
#17
Junhao Chen, Ruihua Zhang, Shaoli Lin, Pengfei Li, Jingjing Lan, Zhijing Xie, Yu Wang, Shijin Jiang
BACKGROUND: DNA-launched infectious system is a useful tool with high rescue efficiency that allows the introduction of mutations in specific positions to investigate the function of an individual viral element. Rescued virus particles could be harvested by directly transfecting the DNA-launched recombinant plasmid to the host cells, which will reduce labor and experimental cost by skipping the in vitro transcription assay. METHODS: A total of four overlapping fragments covering the entire viral genome were amplified and then were assembled into a transformation vector based on pIRES2-EGFP to establish the DNA-launched infectious system of duck hepatitis A virus type 1 (DHAV-1), named pIR-DHAV-1...
November 3, 2017: Virology Journal
https://www.readbyqxmd.com/read/29094032/the-inflammatory-response-of-neutrophils-in-an-in-vitro-model-that-approximates-the-postcardiac-arrest-state
#18
Young-Duck Cho, Sung-Jun Park, Sung-Hyuk Choi, Young-Hoon Yoon, Jung-Youn Kim, Sung-Woo Lee, Chae-Seung Lim
Purpose: Postcardiac arrest syndrome (PCAS) shares many features with sepsis including plasma cytokine elevation with dysregulation of cytokine production, and the presence of endotoxin in plasma. PCAS is closely related to ischemia-reperfusion injury. During ischemia-reperfusion injury, neutrophil, which is the first line of innate immunity, plays a major role. In this study, we investigated the inflammatory response of human neutrophils in an in vitro model which we simulated with hypoxia-normoxia and hypoxia-hyperoxia environments...
October 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29093653/comparison-of-the-commercial-quantiferon-cmv-and-overlapping-peptide-based-elispot-assays-for-predicting-cmv-infection-in-kidney-transplant-recipients
#19
Ji-Soo Kwon, Taeeun Kim, Sun-Mi Kim, Heungsup Sung, Sung Shin, Young Hoon Kim, Eui-Cheol Shin, Sung-Han Kim, Duck Jong Han
Cytomegalovirus (CMV) is one of the most important opportunistic infections in transplant recipients. Tests for CMV-specific T cell responses have been proposed to change the current risk stratification strategy using CMV assays. We evaluated the usefulness of pre-transplant CMV-specific T cell assays in kidney transplant (KT) candidates for predicting the development of CMV infection after transplantation comparing the results of the overlapping peptides (OLPs)-based enzyme-linked immunospot (ELISPOT) assay and the commercial QuantiFERON-CMV assay...
October 2017: Immune Network
https://www.readbyqxmd.com/read/29076646/molecular-epidemiology-of-duck-hepatitis-a-virus-types-1-and-3-in-china-2010-2015
#20
X Wen, D Zhu, A Cheng, M Wang, S Chen, R Jia, M Liu, K Sun, X Zhao, Q Yang, Y Wu, X Chen
Duck hepatitis A virus (DHAV) is the most common aetiologic agent of duck virus hepatitis (DVH), causing substantial economic losses in the duck industry worldwide. In China, officially approved DHAV-1 live-attenuated vaccines have been used widely to vaccinate breeder ducks since 2013. However, following the reports of DVH outbreaks, it has become necessary to assess the epidemiological situation of this virus in China. We conducted molecular epidemiological analyses of 32 DHAV field isolates while analysing the samples from ducks suspected of having hepatitis collected from commercial duck farms in China between May 2010 and December 2015...
October 27, 2017: Transboundary and Emerging Diseases
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