keyword
https://read.qxmd.com/read/38500823/identification-and-verification-of-the-role-of-key-metabolites-and-metabolic-pathways-on-asfv-replication
#21
JOURNAL ARTICLE
Zunji Shi, Xing Yang, Xijuan Shi, Dajun Zhang, Dengshuai Zhao, Yu Hao, Jinke Yang, Xintian Bie, Wenqian Yan, Guohui Chen, Lingling Chen, Xiangtao Liu, Haixue Zheng, Keshan Zhang
African swine fever virus (ASFV) infection usually causes viremia within a few days. However, the metabolic changes in pig serum after ASFV infection remain unclear. In this study, serum samples collected from ASFV-infected pigs at different times were analyzed using pseudotargeted metabolomics method. Metabolomic analysis revealed the dopaminergic synapse pathway has the highest rich factor in both ASFV5 and ASFV10 groups. By disrupting the dopamine synaptic pathway, dopamine receptor antagonists inhibited ASFV replication and L-dopa promoted ASFV replication...
April 19, 2024: IScience
https://read.qxmd.com/read/38493816/deoxycholic-acid-inhibits-asfv-replication-by-inhibiting-mapk-signaling-pathway
#22
JOURNAL ARTICLE
Qi Gao, Yifan Xu, Yongzhi Feng, Xiaoyu Zheng, Ting Gong, Qiyuan Kuang, Qinxin Xiang, Lang Gong, Guihong Zhang
African swine fever (ASF) is an acute, febrile, highly contagious infection of pigs caused by the African swine fever virus (ASFV). The purpose of this study is to understand the molecular mechanism of ASFV infection and evaluate the effect of DCA on MAPK pathway, so as to provide scientific basis for the development of new antiviral drugs. The transcriptome analysis found that ASFV infection up-regulated the IL-17 and MAPK signaling pathways to facilitate viral replication. Metabolome analysis showed that DCA levels were up-regulated after ASFV infection, and that exogenous DCA could inhibit activation of the MAPK pathway by ASFV infection and thus inhibit viral replication...
March 15, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38492520/inhibition-of-pedv-viral-entry-upon-blocking-n-glycan-elaboration
#23
JOURNAL ARTICLE
Yong Zhao, Tao Tang, Wenchang Zhao, Weiguang Fu, Tao Li
Porcine Epidemic Diarrhea Virus (PEDV) poses a significant threat to the global swine industry, demanding a thorough understanding of its cellular invasion mechanism for effective interventions. This study meticulously investigates the impact of O- and N-linked glycans on PEDV proteins and host cell interaction, shedding light on their influence on the virus's invasion process. Utilizing CRISPR-Cas9 technology to inhibit cell surface O- and N-linked glycan synthesis demonstrated no discernible impact on virus infection...
March 12, 2024: Virology
https://read.qxmd.com/read/38490343/caffeic-acid-phenethyl-ester-an-effective-antiviral-agent-against-porcine-reproductive-and-respiratory-syndrome-virus
#24
JOURNAL ARTICLE
Zhanding Cui, Jing Zhang, Jinlong Wang, Jinlong Liu, Pu Sun, Jiaoyang Li, Guoxiu Li, Ying Sun, Juanbin Ying, Kun Li, Zhixun Zhao, Hong Yuan, Xingwen Bai, Xueqing Ma, Pinghua Li, Yuanfang Fu, Huifang Bao, Dong Li, Qiang Zhang, Zaixin Liu, Yimei Cao, Zengjun Lu
Porcine Reproductive and Respiratory Syndrome (PRRS) presents a formidable viral challenge in swine husbandry. Confronting the constraints of existing veterinary pharmaceuticals and vaccines, this investigation centers on Caffeic Acid Phenethyl Ester (CAPE) as a prospective clinical suppressant for the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The study adopts an integrated methodology to evaluate CAPE's antiviral attributes. This encompasses a dual-phase analysis of CAPE's interaction with PRRSV, both in vitro and in vivo, and an examination of its influence on viral replication...
March 13, 2024: Antiviral Research
https://read.qxmd.com/read/38488360/lipidomics-reveals-the-significance-and-mechanism-of-the-cellular-ceramide-metabolism-for-rotavirus-replication
#25
JOURNAL ARTICLE
Ran Tao, Xi Cheng, Laqiang Gu, Jinzhu Zhou, Xuejiao Zhu, Xuehan Zhang, Rongli Guo, Wei Wang, Bin Li
As one of the most important causative agents of severe gastroenteritis in children, piglets, and other young animals, species A rotaviruses have adversely impacted both human health and the global swine industry. Vaccines against rotaviruses (RVs) are insufficiently effective, and no specific treatment is available. To understand the relationships between porcine RV (PoRV) infection and enterocytes in terms of the cellular lipid metabolism, we performed an untargeted liquid chromatography mass spectrometry (LC-MS) lipidomics analysis of PoRV-infected IPEC-J2 cells...
March 15, 2024: Journal of Virology
https://read.qxmd.com/read/38484761/spatio-temporal-epidemiology-of-japanese-encephalitis-virus-infection-in-pig-populations-of-eastern-uttar-pradesh-india-2013-2022
#26
JOURNAL ARTICLE
Himani Dhanze, Balbir B Singh, Michael Walsh, M Suman Kumar, Amit Kumar, Kiran N Bhilegaonkar, Victoria J Brookes
AIMS: Japanese encephalitis (JE) is endemic in India. Although pigs are considered important hosts and sentinels for JE outbreaks in people, limited information is available on JE virus (JEV) surveillance in pigs. METHODS AND RESULTS: We investigated the spatio-temporal distribution of JEV seroprevalence and its association with climate variables in 4451 samples from pigs in 10 districts of eastern Uttar Pradesh, India, over 10 years from 2013 to 2022. The mean seroprevalence of IgG (2013-2022) and IgM (2017-2022) was 14% (95% CI 12...
March 14, 2024: Zoonoses and Public Health
https://read.qxmd.com/read/38479590/approaching-the-complexity-of-crimean-congo-hemorrhagic-fever-virus-serology-a-study-in-swine
#27
JOURNAL ARTICLE
Caroline Bost, Sabrina Castro-Scholten, Balal Sadeghi, David Cano-Terriza, Mario Frías, Saúl Jiménez-Ruiz, Martin H Groschup, Ignacio García-Bocanegra, Kerstin Fischer
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne zoonotic orthonairovirus of public health concern and widespread geographic distribution. Several animal species are known to seroconvert after infection with CCHFV without showing clinical symptoms. The commercial availability of a multi-species ELISA has led to an increase in recent serosurveillance studies as well as in the range of species reported to be exposed to CCHFV in the field, including wild boar (Sus scrofa). However, development and validation of confirmatory serological tests for swine based on different CCHFV antigens or test principles are hampered by the lack of defined control sera from infected and non-infected animals...
March 12, 2024: Journal of Virological Methods
https://read.qxmd.com/read/38478379/divergent-pathogenesis-and-transmission-of-highly-pathogenic-avian-influenza-a-h5n1-in-swine
#28
JOURNAL ARTICLE
Bailey Arruda, Amy L Vincent Baker, Alexandra Buckley, Tavis K Anderson, Mia Torchetti, Nichole Hines Bergeson, Mary Lea Killian, Kristina Lantz
Highly pathogenic avian influenza (HPAI) viruses have potential to cross species barriers and cause pandemics. Since 2022, HPAI A(H5N1) belonging to the goose/Guangdong 2.3.4.4b hemagglutinin phylogenetic clade have infected poultry, wild birds, and mammals across North America. Continued circulation in birds and infection of multiple mammalian species with strains possessing adaptation mutations increase the risk for infection and subsequent reassortment with influenza A viruses endemic in swine. We assessed the susceptibility of swine to avian and mammalian HPAI H5N1 clade 2...
April 2024: Emerging Infectious Diseases
https://read.qxmd.com/read/38478359/molecular-detection-of-ovine-gammaherpesvirus-2-in-free-ranging-wild-boars-sus-scrofa-from-southern-brazil
#29
JOURNAL ARTICLE
Selwyn Arlington Headley, Carolina Yuka Yasumitsu, Alais Maria Dall Agnol, Tatiana Carolina Gomes Dutra de Souza, Gisele da Silva Porto, Raquel Arruda Leme, Alice Fernandes Alfieri, Amauri Alcindo Alfieri
Ovine gammaherpesvirus 2 (OvGHV2) is a member of Macavirus genus, subfamily Gammaherpesvirinae, family Herpesviridae, and causes sheep associated-malignant catarrhal fever (SA-MCF) in a wide range of ungulates. However, no descriptions of SA-MCF and/or infections due to OvGHV2 were identified in the wild boar (Sus scrofa). This study investigated the occurrence of OvGHV2 in the lungs (n = 44) of asymptomatic, free ranging wild boars captured in several regions of Paraná State, Southern Brazil...
March 13, 2024: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://read.qxmd.com/read/38476866/swine-influenza-a-virus-infection-dynamics-and-evolution-in-intensive-pig-production-systems
#30
JOURNAL ARTICLE
Paula Lagan, Michael Hamil, Susan Cull, Anthony Hanrahan, Rosanna M Wregor, Ken Lemon
Swine influenza A virus (swIAV) is one of the main viral pathogens responsible for respiratory disease in farmed pigs. While outbreaks are often epidemic in nature, increasing reports suggest that continuous, endemic infection of herds is now common. The move towards larger herd sizes and increased intensification in the commercial pig industry may promote endemic infection; however, the impact that intensification has on swIAV infection dynamics and evolution is unclear. We carried out a longitudinal surveillance study for over 18 months on two enzootically infected, intensive, indoor, and multi-site pig production flows...
2024: Virus Evolution
https://read.qxmd.com/read/38474030/mass-spectrometry-based-proteomic-analysis-of-potential-host-proteins-interacting-with-gp5-in-prrsv-infected-pams
#31
JOURNAL ARTICLE
Wen Li, Yueshuai Wang, Mengting Zhang, Shijie Zhao, Mengxiang Wang, Ruijie Zhao, Jing Chen, Yina Zhang, Pingan Xia
Porcine reproductive and respiratory syndrome virus (PRRSV) is a typical immunosuppressive virus causing a large economic impact on the swine industry. The structural protein GP5 of PRRSV plays a pivotal role in its pathogenicity and immune evasion. Virus-host interactions play a crucial part in viral replication and immune escape. Therefore, understanding the interactions between GP5 and host proteins are significant for porcine reproductive and respiratory syndrome (PRRS) control. However, the interaction network between GP5 and host proteins in primary porcine alveolar macrophages (PAMs) has not been reported...
February 28, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473085/animal-welfare-assessment-and-meat-quality-through-assessment-of-stress-biomarkers-in-fattening-pigs-with-and-without-visible-damage-during-slaughter
#32
JOURNAL ARTICLE
Natália Nami Ogawa, Giovanna Lima Silva, Ana Paula Ayub da Costa Barbon, Karina Keller Marques da Costa Flaiban, Caio Abercio da Silva, Luiene Moura Rocha, Ana Maria Bridi
The study aimed to investigate the physiological and meat quality differences between Non-Ambulatory, Non-Injured (NANI), and without apparent abnormalities (non-NANI) pigs in a commercial slaughterhouse setting, focusing on the impact of stress and health conditions on the overall well-being and meat quality of the animals. A total of 241 surgically castrated crossbred male pigs from Southern Brazil were analyzed, with 131 non-NANI pigs and 110 NANI pigs. Infrared orbital temperature, rectal temperature, hematological parameters, and meat quality measurements were collected...
February 23, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38471043/licorice-extract-inhibits-porcine-epidemic-diarrhea-virus-in-vitro-and-in-vivo
#33
JOURNAL ARTICLE
Wenfei Bai, Qinghe Zhu, Jun Wang, Limin Jiang, Donghua Guo, Chunqiu Li, Xiaoxu Xing, Dongbo Sun
Porcine epidemic diarrhea virus (PEDV) causes severe diarrhea and even death in piglets, resulting in significant economic losses to the pig industry. Because of the ongoing mutation of PEDV, there might be variations between the vaccine strain and the prevailing strain, causing the vaccine to not offer full protection against different PEDV variant strains. Therefore, it is necessary to develop anti-PEDV drugs to compensate for vaccines. This study confirmed the anti-PEDV effect of licorice extract (Le) in vitro and in vivo ...
March 2024: Journal of General Virology
https://read.qxmd.com/read/38469309/comparative-analysis-of-swine-leukocyte-antigen-gene-diversity-in-g%C3%A3-ttingen-minipigs
#34
JOURNAL ARTICLE
Sabine E Hammer, Tereza Duckova, Monica Gociman, Sandra Groiss, Clara P S Pernold, Karolin Hacker, Lena Kasper, Julia Sprung, Maria Stadler, Andres Eskjær Jensen, Armin Saalmüller, Nadine Wenzel, Constanca Figueiredo
Worldwide, pigs represent economically important farm animals, also representing a preferred preclinical large animal model for biomedical studies. The need for swine leukocyte antigen (SLA) typing is increasing with the expanded use of pigs in translational research, infection studies, and for veterinary vaccine design. Göttingen Minipigs (GMP) attract increasing attention as valuable model for pharmacological studies and transplantation research. This study represents a first-time assessment of the SLA gene diversity in Göttingen Minipigs in combination with a comparative metadata analysis with commercial pig lines...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38467747/the-transcriptomic-insight-into-the-differential-susceptibility-of-african-swine-fever-in-inbred-pigs
#35
JOURNAL ARTICLE
Mohammad Hossein Banabazi, Graham Freimanis, Lynnette C Goatley, Christopher L Netherton, Dirk-Jan de Koning
African swine fever (ASF) is a global threat to animal health and food security. ASF is typically controlled by strict biosecurity, rapid diagnosis, and culling of affected herds. Much progress has been made in developing modified live virus vaccines against ASF. There is host variation in response to ASF infection in the field and under controlled conditions. To better understand the dynamics underlying this host differential morbidity, whole transcriptome profiling was carried out in twelve immunized and five sham immunized pigs...
March 11, 2024: Scientific Reports
https://read.qxmd.com/read/38458287/development-and-characterization-of-monoclonal-antibodies-against-p37-protein-of-african-swine-fever-virus
#36
JOURNAL ARTICLE
Aiping Wang, Zhuting Chen, Jingming Zhou, Yumei Chen, Yankai Liu, Hongliang Liu, Chao Liang, Xifang Zhu, Ying Zhang, Cheng Xin, Jiaojiao Wei, Bingxue Zhang, Xueyuan Tang, Mengjun Lu, Yanhua Qi, Gaiping Zhang
African Swine Fever Virus (ASFV) is a highly contagious pathogen posing a serious threat to the global swine industry. Despite this, there is currently no effective vaccine against this virus. Within ASFV's core shell structure, p37, a product of polyprotein pp220, shares sequence similarity with SUMO-1 proteases. Localization studies show p37 in various nuclear regions during early infection, shifting to the cytoplasm later on. Research indicates active export of p37 from the nucleus, mediated by CRM1-dependent and -independent pathways...
March 6, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38458048/rotavirus-infection-inhibits-sla-i-expression-on-the-cell-surface-by-degrading-%C3%AE-2%C3%A2-m-via-erad-proteasome-pathway
#37
JOURNAL ARTICLE
Zhaoyang Jing, Ling Wu, Yudi Pan, Liaoyuan Zhang, Xin Zhang, Da Shi, Hongyan Shi, Jianfei Chen, Zhaoyang Ji, Jiyu Zhang, Tingshuai Feng, Jin Tian, Li Feng
Group A Rotavirus (RVA) is a major cause of diarrhea in infants and piglets. β2-microglobulin (β2 M), encoded by the B2M gene, serves as a crucial subunit of the major histocompatibility complex class I (MHC-I) molecules. β2 M is indispensable for the transport of MHC-I to the cell membrane. MHC-I, also known as swine leukocyte antigen class I (SLA-I) in pigs, presents viral antigens to the cell surface. In this study, RVA infection down-regulated β2 M expression in both porcine intestinal epithelial cells-J2 (IPEC-J2) and MA-104 cells...
March 2, 2024: Veterinary Microbiology
https://read.qxmd.com/read/38450664/-viral-co-infections-targeting-the-porcine-respiratory-system-consequences-and-limits-of-the-experimental-systems
#38
JOURNAL ARTICLE
François Meurens, Jianzhong Zhu, Fanny Renois
Coinfections affecting the porcine respiratory system have often been overlooked, in favor of mono-infections, even though they are significantly more common in the field. In pigs, the term 'porcine respiratory complex' is used to describe coinfections involving both viruses, such as, for example, the swine influenza type A virus (swIAV), the porcine respiratory and reproductive syndrome virus (PRRSV), and the porcine circovirus type 2 (PCV-2), as well as bacteria. Until recently, most studies were primarily focused on clinical aspects and paid little attention to the molecular consequences of coinfections...
February 1, 2024: Virologie
https://read.qxmd.com/read/38449049/a-chimeric-porcine-reproductive-and-respiratory-syndrome-virus-1-strain-containing-synthetic-orf2-6-genes-can-trigger-t-follicular-helper-cell-and-heterologous-neutralizing-antibody-responses-and-confer-enhanced-cross-protection
#39
JOURNAL ARTICLE
Shubin Li, Ming Qiu, Shuai Li, Chen Li, Hong Lin, Yuejia Qiu, Wenhao Qi, Binghui Feng, Meng Cui, Shuai Yang, Wanglong Zheng, Shaobin Shang, Kegong Tian, Jianzhong Zhu, Yu Lu, Nanhua Chen
The prevalence of porcine reproductive and respiratory syndrome virus 1 (PRRSV1) isolates has continued to increase in Chinese swine herds in recent years. However, no effective control strategy is available for PRRSV1 infection in China. In this study, we generated the first infectious cDNA clone (rHLJB1) of a Chinese PRRSV1 isolate and subsequently used it as a backbone to construct an ORF2-6 chimeric virus (ORF2-6-CON). This virus contained a synthesized consensus sequence of the PRRSV1 ORF2-6 gene encoding all the envelope proteins...
March 6, 2024: Veterinary Research
https://read.qxmd.com/read/38447796/the-nucleocapsid-protein-facilitates-p53-ubiquitination-dependent-proteasomal-degradation-via-recruiting-host-ubiquitin-ligase-cop1-in-pedv-infection
#40
JOURNAL ARTICLE
Wanyu Dong, Yahao Cheng, Yingshan Zhou, Jingmiao Zhang, Xinya Yu, Haicun Guan, Jing Du, Xingdong Zhou, Yang Yang, Weihuan Fang, Xiaodu Wang, Houhui Song
Porcine epidemic diarrhea virus (PEDV) is a highly contagious enteric pathogen of the coronavirus family and caused severe economic losses to the global swine industry. Previous studies have established that p53 is a host restriction factor for PEDV infection, and p53 degradation occurs in PEDV-infected cells. However, the underlying molecular mechanisms through which PEDV viral proteins regulate p53 degradation remain unclear. In this study, we found that PEDV infection or expression of the nucleocapsid protein downregulates p53 through a post-translational mechanism: increasing the ubiquitination of p53 and preventing its nuclear translocation...
March 4, 2024: Journal of Biological Chemistry
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