keyword
MENU ▼
Read by QxMD icon Read
search

swine infection

keyword
https://www.readbyqxmd.com/read/27930728/profiling-and-identification-of-novel-immunogenic-proteins-of-staphylococcus-hyicus-zc-4-by-immunoproteomic-assay
#1
Lei Wang, Zhi-Wei Wu, Yan Li, Jian-Guo Dong, Le-Yi Zhang, Peng-Shuai Liang, Yan-Ling Liu, Ya-Hua Zhao, Chang-Xu Song
Staphylococcus hyicus has caused great losses in the swine industry by inducing piglet exudative epidermitis (EE), sow mastitis, metritis, and other diseases and is a threat to human health. The pathogenesis of EE, sow mastitis, and metritis involves the interaction between the host and virulent protein factors of S. hyicus, however, the proteins that interact with the host, especially the host immune system, are unclear. In the present study, immunoproteomics was used to screen the immunogenic proteins of S...
2016: PloS One
https://www.readbyqxmd.com/read/27928015/reassortment-between-swine-h3n2-and-2009-pandemic-h1n1-in-the-united-states-resulted-in-influenza-a-viruses-with-diverse-genetic-constellations-with-variable-virulence-in-pigs
#2
Daniela S Rajão, Rasna Walia, Brian Campbell, Phillip C Gauger, Alicia Janas-Martindale, Mary Lea Killian, Amy L Vincent
: Repeated spillovers of the H1N1 pandemic virus (H1N1pdm09) from humans to pigs resulted in substantial evolution of influenza A viruses infecting swine, contributing to the genetic and antigenic diversity of influenza A virus (IAV) currently circulating in swine. The reassortment with endemic swine viruses and maintenance of some of the H1N1pdm09 internal genes resulted in the circulation of different genomic constellations in pigs. Here, we performed a whole genome phylogenetic analysis of 496 IAV circulating in swine from 2009 to 2016 in the U...
December 7, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27927254/informal-networks-in-disaster-medicine
#3
Fadl Bdeir, John W Crawford, Liaquat Hossain
OBJECTIVE: Our study of informal networks aimed to explore information-sharing environments for the management of disaster medicine and public health preparedness. Understanding interagency coordination in preparing for and responding to extreme events such as disease outbreaks is central to reducing risks and coordination costs. METHODS: We evaluated the pattern of information flow for actors involved in disaster medicine through social network analysis. Social network analysis of agencies can serve as a basis for the effective design and reconstruction of disaster medicine response coordination structures...
December 8, 2016: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/27923501/influenza-a-virus-vaccines-for-swine
#4
Amy L Vincent, Daniel R Perez, Daniela Rajao, Tavis K Anderson, Eugenio J Abente, Rasna R Walia, Nicola S Lewis
Economic losses due to influenza A virus (IAV) infections are substantial and a global problem, ranking among the top three major health challenges in the swine industry. Currently, H1 and H3 subtypes circulate in pigs globally associated with different combinations of N1 and N2 subtypes; however, the origin, gene constellation, and antigenic makeup of IAV vary greatly on different continents. Vaccination is one means of mitigating the effects of IAV disease, and vaccines are most effective if the strains included closely match the currently circulating strains in pigs...
November 24, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/27920758/effectiveness-of-f18-fimbrial-antigens-released-by-a-novel-autolyzed-salmonella-expression-system-as-a-vaccine-candidate-against-lethal-f18-stec-infection
#5
Gayeon Won, John H Lee
Porcine edema disease (ED) caused by Shiga toxin 2e producing Escherichia coli expressing F18ab(+) fimbriae (F18ab(+)STEC) frequently occurs in post-weaned piglets, resulting in a significant economic loss in swine industries worldwide. In the present study, we proposed an efficient prevention scheme against ED in which the attenuated Salmonella Typhimurium inactivated by the E-mediated cell lysis to deliver target antigens, FedF and FedA, which function in fimbrial-mediated adhesion and as a major subunit of F18ab+fimbriae, respectively...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27918148/influenza-a-virus-surveillance-in-the-invasive-american-mink-neovison-vison-from-freshwater-ecosystems-northern-spain
#6
H Gholipour, N Busquets, X Fernández-Aguilar, A Sánchez, M P Ribas, G De Pedro, P Lizarraga, O Alarcia-Alejos, C Temiño, O Cabezón
Influenza A viruses (IAVs) are negative-sense, single-stranded and segmented RNA viruses of the Orthomyxoviridae family that may cause acute respiratory disease in a wide range of birds and mammals. Susceptibility of several species within the family Mustelidae to IAVs has been reported as a result of natural or experimental infections. The objectives of this study were to assess whether free-ranging American mink populations from Northern Spain were infected with IAV and try to define the role of this species in the epidemiology of IAV...
December 5, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/27915251/identification-of-a-campylobacter-coli-methyltransferase-targeting-adenines-at-gatc-sites
#7
Vikrant Dutta, Eric Altermann, Maria D Crespo, Jonathan W Olson, Robin M Siletzky, Sophia Kathariou
Campylobacter coli can infect humans and colonize multiple other animals but its host-associated genes or adaptations are poorly understood. Adenine methylation at GATC sites, resulting in MboI resistance of genomic DNA, was earlier frequently detected among C. coli from swine but not among turkey-derived isolates. The underlying genetic basis has remained unknown. Comparative genome sequence analyses of C. coli 6461, a swine-derived strain with MboI-resistant DNA, revealed two chromosomal ORFs, 0059 and 0060, encoding a putative DNA methyltransferase and a conserved hypothetical protein, respectively, which were lacking from the genome of the turkey-derived C...
December 2, 2016: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/27914202/probiotic-roles-of-lactobacillus-spp-in-swine-insights-from-gut-microbiota
#8
REVIEW
Valerie Diane V Valeriano, Marilen P Balolong, Dae-Kyung Kang
The use of lactobacilli as probiotics in swine has been gaining attention due to their ability to improve growth performance and carcass quality, prevent gastrointestinal infection, and most importantly, their 'generally recognised as safe' status. Previous studies support the potential of lactobacilli to regulate host immune systems, enhance gut metabolic capacities, and maintain balance in the gut microbiota. Research on swine gut microbiota has revealed complex gut microbial community structure and showed the importance of Lactobacillus to the host's health...
December 3, 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/27907102/an-investigation-into-the-etiological-agents-of-swine-dysentery-in-australian-pig-herds
#9
Tom La, Nyree D Phillips, David J Hampson
Swine dysentery (SD) is a mucohemorrhagic colitis, classically seen in grower/finisher pigs and caused by infection with the anaerobic intestinal spirochete Brachyspira hyodysenteriae. More recently, however, the newly described species Brachyspira hampsonii and Brachyspira suanatina have been identified as causing SD in North America and/or Europe. Furthermore, there have been occasions where strains of B. hyodysenteriae have been recovered from healthy pigs, including in multiplier herds with high health status...
2016: PloS One
https://www.readbyqxmd.com/read/27905502/immune-responsiveness-of-cd4-t-cells-during-streptococcus-suis-serotype-2-infection
#10
Marie-Pier Lecours, Corinne Letendre, Damian Clarke, Paul Lemire, Tristan Galbas, Marie-Odile Benoit-Biancamano, Jacques Thibodeau, Marcelo Gottschalk, Mariela Segura
The pathogenesis of Streptococcus suis infection, a major swine and human pathogen, is only partially understood and knowledge on the host adaptive immune response is critically scarce. Yet, S. suis virulence factors, particularly its capsular polysaccharide (CPS), enable this bacterium to modulate dendritic cell (DC) functions and potentially impair the immune response. This study aimed to evaluate modulation of T cell activation during S. suis infection and the role of DCs in this response. S. suis-stimulated total mouse splenocytes readily produced TNF-α, IL-6, IFN-γ, CCL3, CXCL9, and IL-10...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27902762/presenting-influenza-a-m2e-antigen-on-recombinant-spores-of-bacillus-subtilis
#11
Tomasz Łęga, Paulina Weiher, Michał Obuchowski, Dawid Nidzworski
Effective vaccination against influenza virus infection is a serious problem mainly due to antigenic variability of the virus. Among many of investigated antigens, the extracellular domain of the M2 protein (M2e) features high homology in all strains of influenza A viruses and antibodies against M2e and is protective in animal models; this makes it a potential candidate for generation of a universal influenza vaccine. However, due to the low immunogenicity of the M2e, formulation of a vaccine based on this antigen requires some modification to induce effective immune responses...
2016: PloS One
https://www.readbyqxmd.com/read/27902420/interleukin-1-receptor-antagonist-il-1ra-an-early-immunomodulatory-cytokine-induced-by-porcine-reproductive-and-respiratory-syndrome-virus-prrsv
#12
Teerawut Nedumpun, Piya Wongyanin, Chaitawat Sirisereewan, Patcharee Ritprajuk, Tanapat Palaga, Roongroje Thanawongnuwech, Sanipa Suradhat
Porcine reproductive and respiratory syndrome virus (PRRSV) infection poorly induces pro-inflammatory cytokines (IL-1, IL-6, TNF-α) and type I IFN production during the early phase of infection. Our microarray analysis indicated strong upregulation of the IL1RA gene in type 2 PRRSV infected monocyte-derived dendritic cells (MoDC). Interleukin-1 receptor antagonist (IL-1Ra) is an early inhibitory cytokine, which suppresses pro-inflammatory cytokines and T lymphocyte responses. To investigate the induction of IL-1Ra by PRRSV, MoDC were cultured with type 2 PRRSV or other swine viruses...
November 23, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27902360/high-genetic-diversity-of-species-a-rotaviruses-detected-in-swine-farms-in-chile
#13
Hernan Canon Jones, Hernan Cortes, Aldo Gaggero, Jorge Levican, Mario Castillo-Ruiz, Trinidad Schlotterbeck, Ricardo San Martin
Rotavirus A is one of the main causative agents of diarrhea in lactating and weaned pigs worldwide. Its impact in the swine industry is well documented. However, in Chile the current epidemiological status of rotavirus in porcine farms is unknown. This study evaluated the current epidemiologic status of rotavirus A infection in Chile using on-farm detection technique, electrophoretic confirmation, genotyping and phylogenetic clustering by analysis of partial sequences of VP4 and VP7 genes. Rotavirus A was detected in 4 out of 5 farms with an overall prevalence of 17,7% in diarrheic pigs...
November 18, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27902357/pathogenesis-of-senecavirus-a-infection-in-finishing-pigs
#14
Lok R Joshi, Maureen H V Fernandes, Travis Clement, Steven Lawson, Angela Pillatzki, Talita P Resende, Fabio Vanucci, Gerald F Kutish, Eric Nelson, Diego G Diel
Senecavirus A (SVA) is an emerging picornavirus that has been recently associated with vesicular disease and neonatal mortality in swine. Many aspects of SVA infection biology and pathogenesis, however, remain unknown. Here the pathogenesis of SVA was investigated in finishing pigs. Animals were inoculated via the oronasal route with a contemporary SVA strain SD15-26 and monitored for clinical signs and lesions associated with SVA infection. Viremia was assessed in serum and virus shedding monitored in oral and nasal secretions and feces by real-time reverse transcriptase PCR (RT-qPCR) and/or virus isolation...
October 14, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27899159/p53-signaling-modulation-of-cell-cycle-arrest-and-viral-replication-in-porcine-circovirus-type-2-infection-cells
#15
Dan Xu, Qian Du, Cong Han, Zengguo Wang, Xiujuan Zhang, Tongtong Wang, Xiaomin Zhao, Yong Huang, Dewen Tong
Porcine circovirus type 2 (PCV2) is a ubiquitous pathogen in the swine industry worldwide. Previous studies have shown that PCV2 infection induces host cell apoptosis through up-regulation of p53. To further identify the regulatory roles of p53 signaling in the process of PCV2 infection, we established p53 gene knockout PK15 cell lines using the genomic editor tool CRISPR/Cas9, and further investigated the roles of p53 in modulating the cell cycle and viral replication in this study. The results show that PCV2 infection induced obvious S phase accumulation in wild-type PK15 cells and a compromised S phase accumulation in the p53 gene mutation cells (813PK15 (p53m/m) ), but did not induce obvious S phase accumulation in the p53 gene knockout cells (148PK15 (p53-/-)) compared with the respective mock infection...
November 29, 2016: Veterinary Research
https://www.readbyqxmd.com/read/27899125/preventive-measures-aimed-at-minimizing-the-risk-of-african-swine-fever-virus-spread-in-pig-farming-systems
#16
REVIEW
Silvia Bellini, Domenico Rutili, Vittorio Guberti
African swine fever (ASF) is one of the most severe diseases of pigs; it has a drastic impact on the pig industry, causing serious socio-economic consequences to pig farmers and pork producers. In Europe, there are currently two main clusters of infection; one in Sardinia caused by strains of African swine fever virus (ASFV) belonging to genotype I and another in Eastern Europe caused by strains of ASFV belonging to genotype II. The latter is inducing an acute form of ASF and it represents a serious threat to the pig sector...
November 29, 2016: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/27898335/genetically-edited-pigs-lacking-cd163-show-no-resistance-following-infection-with-the-african-swine-fever-virus-isolate-georgia-2007-1
#17
Luca Popescu, Natasha N Gaudreault, Kristen M Whitworth, Maria V Murgia, Jerome C Nietfeld, Alan Mileham, Melissa Samuel, Kevin D Wells, Randall S Prather, Raymond R R Rowland
African swine fever is a highly contagious, often fatal disease of swine for which there is no vaccine or other curative treatment. The macrophage marker, CD163, is a putative receptor for African swine fever virus (ASFV). Pigs possessing a complete knockout of CD163 on macrophages were inoculated with Georgia 2007/1, a genotype 2 isolate. Knockout and wild type pen mates became infected and showed no differences in clinical signs, mortality, pathology or viremia. There was also no difference following in vitro infection of macrophages...
November 26, 2016: Virology
https://www.readbyqxmd.com/read/27897246/rapid-control-of-pandemic-h1n1-influenza-by-targeting-nkt-cells
#18
Bianca L Artiaga, Guan Yang, Tarun E Hutchinson, Julia C Loeb, Jürgen A Richt, John A Lednicky, Shahram Salek-Ardakani, John P Driver
Swine influenza A viruses (IAV) are a major cause of respiratory disease in pigs and humans. Currently approved anti-influenza therapies directly target the virus, but these approaches are losing effectiveness as new viral strains quickly develop drug resistance. To over come this challenge, there is an urgent need for more effective antiviral drugs. Here we tested the anti-influenza efficacy of the invariant natural killer T (NKT) cell superagonist, α-galactosylceramide (α-GalCer), which stimulates a wide array of anti-viral immune responses...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27894861/development-of-a-competitive-double-antibody-lateral-flow-assay-for-the-detection-of-antibodies-specific-to-glycoprotein-b-of-aujeszky-s-disease-virus-in-swine-sera
#19
V V Vrublevskaya, V N Afanasyev, A A Grinevich, Yu Y Skarga, P P Gladyshev, S A Ibragimova, D V Krylsky, O S Morenkov
Three lateral flow assays (LFAs) for the detection of antibodies against glycoprotein B (gB) of Aujeszky's disease virus (ADV) in swine sera: a competitive double antibody sandwich LFA without a preincubation step (CDAS-gB-LFA), a CDAS-gB-LFA with a preincubation step (pCDAS-gB-LFA), and a competitive direct gB-LFA have been developed and were compared with each other and with a gB-ELISA. The assays are based on monoclonal antibodies to immunodominant epitopes of ADV gB. The pCDAS-gB-LFA proved to be the most specific and sensitive assay to detect antibodies directed to ADV gB...
November 25, 2016: Journal of Virological Methods
https://www.readbyqxmd.com/read/27891118/colistin-in-pig-production-chemistry-mechanism-of-antibacterial-action-microbial-resistance-emergence-and-one-health-perspectives
#20
REVIEW
Mohamed Rhouma, Francis Beaudry, William Thériault, Ann Letellier
Colistin (Polymyxin E) is one of the few cationic antimicrobial peptides commercialized in both human and veterinary medicine. For several years now, colistin has been considered the last line of defense against infections caused by multidrug-resistant Gram-negative such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Colistin has been extensively used orally since the 1960s in food animals and particularly in swine for the control of Enterobacteriaceae infections. However, with the recent discovery of plasmid-mediated colistin resistance encoded by the mcr-1 gene and the higher prevalence of samples harboring this gene in animal isolates compared to other origins, livestock has been singled out as the principal reservoir for colistin resistance amplification and spread...
2016: Frontiers in Microbiology
keyword
keyword
78849
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"